530 results about "Covalent binding" patented technology

The invention relates to an activated metallic, semiconductor, polymer, composite and/or ceramic substrate, the substrate being bound through a mixed or graded interface to a hydrophilic polymer surface that is activated to enable direct covalent binding to a functional biological molecule, the polymer surface comprising a sub-surface that includes a plurality of cross-linked regions, as well as to such activated substrates that have been functionalised with a biological molecule and to devices comprising such functionalised substrates. Such substrates can be produced by a method comprising steps of: a. exposing a surface of the substrate to any or more of (i) to (iii): (i) plasma ion implantation with carbon containing species; (ii) co-deposition under conditions in which substrate material is deposited with carbon containing species while gradually reducing substrate material proportion and increasing carbon containing species proportion; (iii) deposition of a plasma polymer surface layer with energetic ion bombardment; incubating the surface treated according to step (a) with a desired biological molecule.

Methods and solutions for forming self assembled organic monolayers that are covalently bound to metal interfaces are presented along with a device containing a self assembled organic monolayer. Embodiments of the present invention utilize self assembled thiolate monolayers to prevent the electromigration and surface diffusion of copper atoms while minimizing the resistance of the interconnect lines. Self assembled thiolate monolayers are used to cap the copper interconnect lines and chemically hold the copper atoms at the top of the lines in place, thus preventing surface diffusion. The use of self assembled thiolate monolayers minimizes the resistance of copper interconnect lines because only a single monolayer of approximately 10 Å and 20 Å in thickness is used.

The invention discloses a preparation method for an antibacterial coat for slowly releasing various cell growth factors on medical metal. According to the method, antibiotic with amino is grafted on graphene oxide by covalent binding, the graphene oxide grafted with the antibiotic is taken as a carrier, and nano-particles, which wrap the various cell growth factors respectively, are fixed between grapheme oxide layers by layer-by-layer self-assembly, so that the coat, which carries the various cell growth factors and the antibiotic at the same time, is obtained on the surface of the medical metal. The coat prepared by the method can independently control the various cell growth factors to be slowly and orderly released, the fixation amount of the cell growth factors is large and the bone induction effect is strong. In addition, the coat can release the antibiotic in the whole process of the slow release of the cell growth factors, thus achieving a long-term antibacterial effect. In addition, the cell growth factors do not interact with the antibiotics, so that the respective efficacy of the cell growth factors and the antibiotics is given full play.

The invention discloses a ratio-type fluorescent probe based on a carbon dot and a europium complex, a preparation method of the ratio-type fluorescent probe and an application method of the ratio-type fluorescent probe in a water sample detection technology. A hyperfluorescence rare earth complex and the carbon dot are taken as a double luminous center, a covalent binding manner is adopted for bonding two luminophors together, and ratio-type detection on Cu<2+> ions in a water sample is carried out by virtue of strength ratio of the hyperfluorescence rare earth complex to the carbon dot. The ratio-type fluorescent probe has good selectivity and sensitivity.

An adhesion preventive material including a cross-linking polysaccharide derivative containing at least one active ester group introduced in a polysaccharide side chain, which is capable of reacting with an active hydrogen-containing group, and being capable of forming a crosslinked material due to covalent binding among the active ester group and an active hydrogen-containing group upon contact with water under an alkaline condition, is disclosed. The adhesion preventive material is able to reduce preparation works to be carried out while previously estimating the time of application and dose not require a special device.

The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.

The present invention relates to the covalent binding of a hydrogel to an extracellular matrix (ECM). The integration of the hydrogel with the tissue is superior to that in previous techniques. Moreover, unlike previous techniques, the present invention does not require a photoinitiator. Potential therapeutic applications include tissue repair and delivery of drugs or cells. The ECM is first exposed, then treated with a priming agent. Then a polymerizable agent is added and crosslinked to the ECM. Two primary embodiments of methods are disclosed. In the first, the priming agent is an oxidizer which creates tyrosyl radicals in the ECM, which are then bound by acrylate groups in the polymerizable agent. In the second, the priming agent contains aldehydes which bind amino groups in the ECM.

This invention features a compound of the following formula: T-(-L-C)m, T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.

The invention discloses a preparation method of a graphene/polyaniline covalent binding conductive fabric, which belongs to the technical field of textile chemistry. The preparation method comprises the steps of applying oxidized graphene or oxidized graphene derivative and a reaction product of p-phenylenediamine onto the fabric to be reduced, enabling the fabric to adsorb the polyaniline monomer, enabling the in-situ polymerization of the polyaniline monomer on the fabric to form polyaniline, and enabling the polyaniline to form covalent key combination with the graphene. According to the method, a conductive layer formed by covalently combining the graphene and polyaniline can be acquired on the surface of the fabric, so that the stability of the conductive layer is improved, and the conductive fabric with excellent effect can be acquired. The method is applicable to conventional fabrics such as natural fibers including cotton, wool, silk and the like, synthesized fibers including terylene, chinlon, acrylic fibers and the like and blending of fabric or conductive arrangement of intertexture, and the prepared functional fabric can be applied to the fields of medical healthcare, intelligent sensors, mobile power generation, military and the like.

Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, and at least one alginate, e.g., sodium alginate, wherein:the at least one glycosaminoglycan and/or the algninate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; orthe at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; orthe at least one glycosaminoglycan and/or the algninate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and,gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and,methods for making and using such compositions and gels, including products therefrom such as "paints", sprays, matrices, beads, microcapsules.

The invention relates to a block copolymer containing: a) hydrophobic biodegradable polymer; b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the hydrophilic polymer b). The invention relates to shaped bodies consisting of the block copolymer and to their utilization, particularly as carriers for tissue culture and active substances and for controlled release and targeted administration of active substances.

The invention discloses a preparation method of polylactic acid functionalized graphene, which comprises the steps of preparing graphite oxide by adopting an improved Hummers method; performing ultrasonic peeling and freeze drying to obtain graphene oxide; mixing the graphene oxide with anhydrous lactic acid at certain proportion; adding a catalyst, and performing in-situ polymerization in vacuum environment to obtain a graphene/polylactic acid complex; and washing off the polylactic acid not in covalent binding with graphene to obtain polylactic acid functionalized graphene. The preparation method of polylactic acid functionalized graphene provided by the invention takes graphene oxide as an initiator and grafts polylactic acid to the surface of graphene oxide through lactic acid condensation polymerization by adopting a one-step method. The method does not need to perform pretreatment on graphene; the treatment process of lactic acid condensation polymerization is relatively simple and easy to realize, and the cost is relatively low. Moreover, the surface of graphene oxide is rich in oxygen-containing functional groups such as carboxyl group, hydroxyl group and the like; and relatively high grafting rate can be obtained through simple treatment.

Protein-based photovoltaic cells and the manufacture and use of protein-based photovoltaic cells are described. In one embodiment, bacteriorhodopsin from Halobacterium salinarum, which undergoes structural transitions when irradiated with a given wavelength of light, is used as the protein in the protein-based photovoltaic cells. In another embodiment, mutant bacteriorhodopsin from H. salinarum is used. Exposure of the protein to sunlight causes proton transfer across a membrane resulting in the generation of an electrical charge. The protein can be oriented and/or layered on a substrate and modified by mutation to enhance transmembrane proton transfer, covalent binding to a substrate and layering. The protein-based photovoltaic cells sequentially or simultaneously generate hydrogen gas from water or salt, which also can be harnessed to produce electricity.