716 results about "Thiophene" patented technology

The invention discloses a preparation method of a grafted and substituted thiophene polymer material, which comprises the following steps: mixing poly (3-hexylthiophene), a grafting monomer, a catalyst and an auxiliary agent, and heating for reaction to obtain the grafted and substituted thiophene polymer material, the structural formula of the grafting monomer is as shown in formula (I); wherein B is fluorine, chlorine, bromine or iodine, A is a carbon atom or a nitrogen atom, and R is cyano, formyl, methoxycarbonyl or; according to the method, pre-synthesis of complex functional monomers is avoided, the main chain of the poly (3-hexylthiophene) can be directly modified without using an expensive catalyst or ligand, the polymerization reaction of the poly (3-hexylthiophene) is not interfered, and meanwhile, the method has the advantages of simplified steps and low cost.

The invention discloses a carbazole phosphonate-thiophene copolymer as well as a preparation method and application thereof. The structural formula of the carbazole phosphonate-thiophene copolymer is shown as a formula (I), according to the invention, the carbazole phosphonate compound and the thiophene compound are copolymerized, and the obtained copolymer is used for preparing the hole transport layer of the perovskite solar cell, so that the perovskite solar cell has relatively high photoelectric conversion efficiency, and the relatively high photoelectric conversion efficiency can be kept in a humid and hot environment.

The invention belongs to the technical field of organic dye synthesis and application, and discloses a conjugated compound containing a benzothiophenazine structure as well as a preparation method and application thereof, and the conjugated compound containing the benzothiophenazine structure has excellent photophysical properties, singlet oxygen yield and superoxide anion generation capacity. The novel conjugated compounds ENBO-NI and ENBS-NI containing benzothiophenazine structures are successfully prepared by replacing a benzene ring of Nile blue with a cycloalkane structure and adjusting the electron donating ability of an R1 group. The two compounds have near infrared fluorescence emission, good solubility and relatively high ROS yield. Compared with a classical photosensitizer NB, the singlet oxygen yield of ENBO-NI is increased by about 117.65%, and the singlet oxygen yield of ENBS-NI is as high as 70%. The absorption wavelength of the conjugated compound is in a red light wave band. The preparation process is simple and efficient, large-scale production is easy, and the preparation method has a wide clinical application prospect.

The invention relates to preparation of a crystalline allyl covalent organic framework material and application research of the crystalline allyl covalent organic framework material in benzamide cyclization green photocatalytic conversion. The SF-COF material is prepared by adopting a step-by-step synthesis method. The preparation method comprises the following steps: synthesizing a COF precursor by taking 1, 3-benzenetricarboxaldehyde and p-aminophenylacetonitrile as raw materials, and preparing the allylation covalent organic framework material with the electronic push-pull effect from the COF precursor and 5, 5 ', 5'-(benzene-1, 3, 5-triyl) tri (thiophene-2-formaldehyde) through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and benzamide cyclization and conversion of derivatives of benzamide are achieved under irradiation of a blue light LED. The prepared SF-COF has the advantages of efficient charge separation and electron conduction performance, good structural stability and chemical stability and the like. And a catalyzed organic reaction substrate has the advantages of wide universality range, good cycle stability and the like, and shows excellent photocatalytic conversion capability.

The invention discloses a precise construction strategy of a dibenzothiophene sulfuryl covalent organic framework material and systematically explains efficient application of the dibenzothiophene sulfuryl covalent organic framework material in photocatalytic synthesis of thiadiazole and derivatives thereof. The achievement relates to a plurality of leading subjects such as catalytic chemistry, organic synthesis, material science, environmental engineering and green chemistry. According to the method, 2, 4, 6-triformyl phloroglucinol and 3, 7-diaminodibenzo [b, d] thiophene-5, 5-dioxide are taken as construction units, and the crystalline S-COF rich in sulfuryl active sites can be quantitatively obtained through topology-oriented Schiff base condensation under the conditions of protonic acid catalysis, no water and no oxygen. Under the radiation condition of visible blue light, S-COF is used as a heterogeneous photocatalyst to drive green synthesis of 3, 5-di-p-tolyl-1, 2, 4-thiadiazole and series of derivatives thereof; the invention provides a new catalyst design normal form for light-induced organic conversion, and lays a solid foundation for sustainable development-oriented efficient synthesis chemistry.

This invention belongs to the field of chemical synthesis and relates to a method for achieving deuterated methylation of a nucleophile. The invention provides a deuterated methylating reagent, which is obtained by reacting formic acid with deuterated methanol under acidic conditions, followed by a second reaction with thiaanthracite and trifluoromethanesulfonic acid. The nucleophile is then reacted with the deuterated methylating reagent described in claim 1, a base, and a solvent to obtain the deuterated methylated product. This invention also provides a method for achieving deuterated methylation of a nucleophile, which involves dissolving the nucleophile and 5-deuterated methyl-5H-thiophene-5-onium trifluoromethanesulfonate in a suitable solvent, adding a base, and then performing the deuterated methylation reaction at room temperature. In the method provided by this invention, the yield of the product after nucleophile methylation can reach 52% to 95%.

This application provides a method for preparing compound I-b or a pharmaceutically acceptable salt thereof, wherein (S)-N-methylamino-1-(2-thiophene)-1-propanol reacts with 4-fluorobenzo[1,3]dioxolane in a system containing sodium hydride and potassium benzoate to obtain compound I-b. This method has short steps, mild reaction conditions, and is simple to operate, making it suitable for industrial scale-up; moreover, the obtained product has high purity and low isomer content.

Liquid-crystalline compounds with a terminal 5,6-difluoro-benzo[b]thiophene ring as provided by formula I, liquid crystal mixtures using the compounds, the use of the compounds in an electro-optical display, particularly in an active-matrix display based on the IPS or FFS effect, and liquid crystal displays that contain a liquid crystal material of this type.

The invention relates to the technical field of hydrodesulfurization catalysts, and discloses a molecular sieve hydrodesulfurization catalyst and a preparation method thereof.Active Si-Cl bonds of maleate methyl dichlorosilane react with hydroxyl in an MCM-41 molecular sieve, then hydrolysis is conducted through sodium hydroxide, and therefore a large number of carboxyl groups are grafted in the molecular sieve; carboxyl can form a strong coordination effect with metal ions such as nickel and the like, so that nickel and molybdenum are uniformly adsorbed into a matrix of the molecular sieve, a nickel-molybdenum oxide catalytic active center is uniformly generated in the molecular sieve through high-temperature roasting, catalytic sites are not easy to agglomerate, the dispersity is good, and the catalytic activity is stable. The catalyst can effectively perform hydrogenation reaction on sulfur-containing substances such as thiophenes in straight-run diesel oil, and has higher desulfurization rate. The catalyst has good practical application in the aspects of oil hydrodesulfurization catalysis and the like.

A novel salt form of Compound (I) represented by the following structural formula, and its corresponding pharmaceutical compositions, are disclosed.Particular single crystalline forms of 1:1 Compound (I) tartrate salt are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms are also disclosed. The present disclosure also provides methods of treating cancer in a subject.

The present invention discloses a series of fused polycyclic substituted 5-carboxylic acid thienopyrimidinedione compounds and their uses, specifically, those of formula (II): The compound represented by TIFF2024507408000065.tif5475 and pharma- ceutically acceptable salts thereof are disclosed.

The present application provides compounds of Formula (I):or a pharmaceutically acceptable salt thereof, that are inhibitors of cyclin-dependent kinase 4 (CDK4), as well as pharmaceutical compositions thereof, and methods of treating cancer using the same.

The application belongs to the technical field of self-repairing materials, and particularly relates to a kind of double-microcapsule self-repairing water-based polyurethane material and its preparation method. It comprises: ultrasonic dispersion of cellulose nanocrystals in deionized water to form an aqueous phase, adding dry oil and sodium dodecyl sulfate, and stirring to obtain a dry oil microcapsule with a Pickering emulsion as a template. Then, polyvinylpyrrolidone aqueous solution, non-polar solvent solution of thiophene monomer and ammonium persulfate aqueous solution are prepared. The first two are mixed and ultrasonically dispersed, then mixed with the ammonium persulfate aqueous solution and stirred to polymerize. After the reaction is completed, polythiophene microcapsule suspension is obtained. After centrifugation, the supernatant is colorless. The solid is washed and dried to obtain polythiophene microcapsules. Finally, the two kinds of microcapsules are added to the water-based polyurethane, mixed uniformly, dried at room temperature to form a double-microcapsule self-repairing water-based polyurethane material. The application realizes the self-repairing and mechanical property improvement of the double-microcapsule self-repairing water-based polyurethane material under room temperature natural light.

The invention provides a synthesis method of a thioether ligand and a palladium-catalyzed 2-aryl indole compound, and designs an application of the biphenyl thioether ligand and a palladium catalyst in preparation of the 2-aryl indole compound. Indole and arylboronic acid are subjected to a reaction under the action of a palladium catalyst and a biphenyl sulfide ligand, and the structural formula of the biphenyl sulfide ligand is shown in the specification. Ar is phenyl, furyl, thienyl, naphthyl or phenyl substituted by one or more substituent groups; r1 is methyl, methoxyl, fluorine atom, chlorine atom, bromine atom or methyl ester group; r2 is the same or different and is methyl, ethyl, isopropyl, isobutyl, cyclohexyl, benzyl, n-butyl or n-hexyl; r3 is alkoxy, alkylthio, substituted amino or halogen; the palladium catalyst is a divalent palladium compound.

The application discloses two kinds of metal organic framework materials Zr-TTB-1 and Zr-TTB-2, a preparation method thereof and application thereof in methane adsorption. The preparation method comprises the following steps: firstly, synthesizing an organic ligand TTB containing a five-membered thiophene ring under specific and suitable conditions by taking 1,3,5-tri(thiophene-2-yl) benzene as a raw material; and then preparing stable two kinds of metal organic framework materials under specific and suitable conditions by combining the organic ligand TTB with a Zr6 metal cluster. The synthesis and preparation method route is simple, the operation is simple, the cost is low, and the method is suitable for efficient methane adsorption and storage.

The invention discloses a fullerene dumbbell photocatalyst for improving photocatalytic hydrogen production performance through electron delocalization. The fullerene dumbbell photocatalyst has an acceptor-donor-acceptor characteristic, is of a fullerene-thiophene fused ring dumbbell-shaped structure, comprises two symmetrically modified fullerene carbon cages, is bridged by a fused ring electron donor in the middle, and is similar to a dumbbell in shape. The fullerene dumbbell compound has the structural characteristic as shown in the formula I. The catalyst is simple in preparation process and high in design regularity. Importantly, the dumbbell molecular photocatalyst has a remarkable electron delocalization property, so that the photocatalytic hydrogen production performance is greatly improved. According to the invention, beneficial guidance is provided for design of an efficient photocatalyst and photocatalytic hydrogen production.

The present application relates to a kind of thieno [2, 3-c] pyridazine derivatives, and its isotope form, stereoisomer, tautomer, cis-trans isomer, pharmaceutically acceptable salt, pharmaceutically acceptable solvate, hydrate, prodrug and polymorph, these compounds can be used as cholinergic M4 receptor positive allosteric modulator, it has good application prospect in preparation for preventing and / or treating the drug for the disease related to abnormal muscarinic acetylcholine receptor.

This application relates to a terphenylamine skeleton compound, its preparation method, and its application, belonging to the field of chemical synthesis technology. The preparation method of the terphenylamine skeleton compound of this application includes the following steps: dissolving 2,4,6-triphenylaniline with thiazole-4-carboxaldehyde or thiophene-3-carboxaldehyde in a solvent, conducting a reductive amination reaction under reducing agent conditions, quenching, extraction, washing, concentration to remove solvent, and purification to obtain the terphenylamine skeleton compound. This application provides a simple and mild synthetic method for the natural active products 5'-phenyl-N-(thiazol-4-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine and 5'-phenyl-N-(thiophene-3-ylmethyl)-[1,1':3',1''-terphenyl]-2'-amine, which can only be extracted from the secondary metabolites of the marine fungus Aspergillus sp. Furthermore, this method utilizes widely available raw materials, which is beneficial for large-scale industrial production of these natural active products.

The invention discloses a functionalized polycarbonate material and a preparation method thereof, and belongs to the field of high polymer materials. The material takes carbon dioxide as a green monomer, double-bond active sites are pre-buried in a polycarbonate main chain through ring-opening copolymerization, and carboxyl, amino or heterocyclic functional side chains are efficiently grafted through thiol-ene click reaction. The preparation method comprises the following steps: under the action of a composite catalyst, copolymerizing a double-bond-containing monomer, propylene oxide and COO to synthesize a precursor; and driving the sulfydryl monomer to carry out click reaction through thermal or photo-initiation. The innovation point lies in that the limitation of traditional protection / deprotection is broken through, multiple functions are integrated, hydrophilic carboxyl, antibacterial amino and conductive thiophene group have a synergistic effect, meanwhile, high mechanical strength and controllable degradability are kept, and the preparation method is suitable for the fields of biomedicine and electronics.

This invention relates to the field of electrochromic thin film technology, and more particularly to a dithiophene derivative, its preparation method, and its application, as well as an electrochromic thin film and its preparation method. This invention involves reacting dithiophene with tributyltin chloride to generate tin-modified dithiophene, reacting dithiophene with isopropanol pinacol boronic acid ester to generate boron-modified dithiophene, and then reacting the tin-modified or boron-modified dithiophene with 1,4-diiodo-2,5-bis-(6-hexynyl)-benzene to generate 1,4-dithiophene-2,5-bis-(6-hexynyl)-benzene. This product is then reacted with dimethylboron hydride generated from lithium aluminum hydride and dimethoxyethane to finally obtain the dithiophene derivative. This derivative can be applied in electrochromic thin films. This invention successfully prepares an electrochromic thin film with fast response and fluoride ion detection capability by electrochemically polymerizing the dithiophene derivative.

This application relates to the field of display technology, and more particularly to a composite thin film, a multilayer light-emitting device, and a display apparatus; wherein the composite thin film includes a first sublayer, and the material of the first sublayer includes a thiophene compound. The composite thin film of this application can increase the carrier concentration and improve conductivity.

The invention discloses a near-infrared absorption zwitter-ion ethylene-linked covalent organic framework photocatalyst as well as a preparation method and application thereof, and the preparation method comprises the following steps: carrying out hydrothermal reaction on a mixture of an N-(3-sulfopropyl)-2, 4, 6-(trimethyl) pyridine monomer, an aldehyde monomer containing a thiophene unit, organic alkali and water to obtain the near-infrared absorption zwitter-ion ethylene-linked covalent organic framework photocatalyst. The zwitterionic ethylene-linked covalent organic framework photocatalyst ZVCOFs with near-infrared absorption is obtained. According to the method, a one-step green hydrothermal method is adopted, water is used as a solvent, pollution to the environment is reduced, traditional tedious freezing-pumping-unfreezing operation is omitted, high-yield COFs are obtained, and the method has the potential of industrial amplification. The ZVCOFs show excellent hydrophilicity due to rich zwitterionic groups and thiophene units, the light absorption range can be expanded to a near-infrared light region, the light absorption band edge reaches up to 852-1230 nm, and the ZVCOFs have excellent hydrogen evolution performance of photocatalytic water decomposition.

The application belongs to the technical field of chemical separation materials, and relates to a preparation method of a sulfonated polythiophene modified nitrogen-doped honeycomb carbon and Co9S8 composite microsphere integrated flow electrode, which comprises the following steps: taking chitosan as a carbon source and a nitrogen source, adding a cobalt source and a sulfur source, performing cross-linking aging, forming and curing, performing freeze drying and high-temperature carbonization, and obtaining chitosan derived nitrogen-doped honeycomb carbon and Co9S8 composite microspheres; taking thiophene and 3-sulfonic acid thiophene as monomers, coating a sulfonated polythiophene film on the surface of the composite microspheres through chemical polymerization, and obtaining the integrated flow electrode. The high specific capacitance electrode material and the conductive ion exchange membrane function are combined into one, the specific capacitance, the hydrophilicity and the ion selective permeability are significantly improved, the integrated flow electrode is used for deionization technology treatment of uranium-containing wastewater, the uranium removal rate is high, the electric adsorption capacity is large, the balance time is short, the device is simplified, and the application prospect is wide.

The invention belongs to the technical field of organic solar cell materials, and relates to a benzodithiophene polymer donor with a simple and stable structure and a preparation method and application thereof. The invention discloses a benzodithiophene polymer donor PBTQ-X (F / Cl / 2F) with a simple and stable structure, and discloses a preparation method of the benzodithiophene polymer donor PBTQ-X (F / Cl / 2F), and the preparation method comprises the following steps: under the action of a Stille coupling catalyst, carrying out two-stage polymerization on benzodithiophene containing bis (trimethyltin) and a quinoxaline derivative containing a dibromothiophene pi bridge, carrying out two-stage heating reflux reaction, and carrying out post-treatment to obtain the benzodithiophene polymer donor PBTQ-X (F / Cl / 2F). Adding an end-capping reagent for end capping; and finally, settling after passing through methanol, thereby obtaining the product. The benzodithiophene polymer donor with a simple and stable structure can be applied to an active layer of an organic solar cell device, and shows relatively good photovoltaic performance and long-term stability.

Disclosed herein are apyrase inhibitors of Formula (I):Also disclosed herein are methods for using the disclosed inhibitors, including in methods for protecting crops from pests. In one aspect the apyrase inhibitors are useful for enhancing the activity of pesticides for the protection of crops from pathogens and to support crop yield.

The invention relates to an asymmetric small organic molecule photovoltaic acceptor material based on an iodo-thiophene central core as well as a preparation method and application of the asymmetric small organic molecule photovoltaic acceptor material based on the iodo-thiophene central core, and creatively designs the asymmetric small organic molecule photovoltaic acceptor material based on the iodo-thiophene central core. On the basis of keeping the efficient photoelectric property, the asymmetric iodo-thiophene central core is introduced, so that the fine regulation and control on the molecular stacking behavior and the thin film morphology are realized. The asymmetric small organic molecule photovoltaic acceptor material has good solubility in various organic solvents, molecular accumulation can be finely regulated and controlled through asymmetric central core design, intermolecular pi-pi interaction and accumulation of end groups are enhanced, more orderly-arranged and optimized charge transfer channels are formed, and the asymmetric small organic molecule photovoltaic acceptor material has a good application prospect. Therefore, the crystallinity and morphology of the film are improved.

The application discloses a liquid room-temperature phosphorescent organic compound and a preparation method and application thereof, and a structural formula of the organic compound is shown in the following formula: wherein, ring A is selected from pyridine or furan; ring D is selected from pyrrole, thiophene or benzene; G1 and G2 are independently selected from hydrogen, bromine, iodine, ester group, hydroxyl group, cyano group or alkoxy group; R1 is C y H 2y L, and L is halogen. The organic compound in the application exists in a liquid form at room temperature, realizes organic room-temperature phosphorescence, has excellent processing performance and flexibility. The material has strong fluidity, and the compatibility of the material makes the material easy to be mixed with other materials, and the material is easy to be filled in containers of various shapes and narrow spaces. The synthesis route of the application has the advantages of low price of required raw materials, less influence on environment, easy recycling, short synthesis time, high yield and large amount of synthesis in a short time.

The invention provides compounds of formula (IA) and compounds of formula (IB) and pharmaceutically acceptable salts thereof; wherein A is selected from group (A1) and group (A2): wherein #1 is attached to the carbon atom forming the oxime moiety and wherein group (A1) is optionally substituted by one or two R10 and group (A2) is optionally substituted by one R10, and wherein R1, X, R2 and R10 are as defined in the claims, as well as methods of using the compounds to treat neoplastic diseases, in particular cancer.

The present application relates to a kind of preparation method of polythiophene conjugated polymer, in the presence of palladium catalyst, nitrogen-containing heterocyclic ligand, oxidant, deproton ligand and solvent, to be activated aromatic hydrocarbon is directly arylated polymerization reaction one step synthesis polythiophene conductive polymer by oxidation;To be activated aromatic hydrocarbon is one or more of thiophene and its derivatives;The coordination number of nitrogen-containing heterocyclic ligand and palladium is 1, and the coordination number of deproton ligand and palladium is 2;Or, the coordination number of nitrogen-containing heterocyclic ligand and palladium is 2, and the coordination number of deproton ligand and palladium is 1;The reaction transition state of metal synergistic deprotonation step participated by ligand and deproton ligand calculated by density functional theory, the W Pd‑C and W C‑H Sum calculated is not less than 0.75;The method of the present application is simple, fast, and does not need to be pre-activated for monomer, solves the problem of low yield and polymerization degree in the prior art by oxidation direct arylated polymerization to prepare polythiophene polymer.