1086 results about "Hormone" patented technology

In various embodiments, the disclosure provides compositions, such as polypeptides, polynucleotides, gene editing systems, small molecules, vectors, or host cells, comprising and / or modulating the expression or activity of an immunomodulatory-related protein. In various embodiments, the disclosure also provides for the treatment of aging, senescence, fibrosis, metabolic diseases, cardiovascular diseases, endocrine-related disorders, genetic diseases, cancer, infections, immune diseases, and the like using agents comprising and / or modulating the expression or activity of an immunomodulatory-related protein. Methods of replacing an adaptation of therapy or combinations thereof with hormones, growth factors and / or proteins, as well as methods of identifying the agents.

The invention discloses a health degree assessment system and method for endocrine nursing, and relates to the technical field of health assessment, and the system comprises a state vector construction module which is used for collecting basic data of a patient, constructing an individual state vector S, collecting physiological data of the patient in real time, and extracting deep features by using a CNN model; and the anomaly detection module is used for performing dimensionality reduction on the deep features by using PCA, then inputting a mutation point detection algorithm to detect periodic mutation points to obtain a mutation point set, identifying peak activation response by using SNN to obtain a peak anomaly set, and integrating the obtained mutation point set and the peak anomaly set into an anomaly feature vector A. According to the method, dynamic and accurate evaluation of the health state of the endocrine patient is achieved, accurate multi-symptom risk prediction can be achieved through real-time monitoring and automatic recognition of hormone fluctuation, behavior abnormity and health state changes, a personalized nursing intervention plan can be generated according to the individual health state, and therefore the nursing efficiency is improved.

The invention relates to the technical field of database construction, in particular to a construction method and system for a reproductive medicine database. The method comprises the following steps: acquiring a biological tissue sample of a patient; acquiring reproductive endocrine hormone data, embryo morphological parameter data, immune cell function data and genome variation data from the biological tissue sample of the patient; performing time sequence analysis processing on the hormone fluctuation mode according to the reproductive endocrine hormone data to obtain endocrine dynamic characteristic data; performing image recognition processing based on coherent superposition characteristics of light on the embryo morphological parameter data, and performing embryo development potential evaluation to obtain embryo development potential data; and performing hierarchical clustering processing on the individual heterogeneity of the patient according to the immune cell function data and the genome variation data to obtain immune-genetic typing data of the patient. By means of the quantum dot sensing technology and the multi-channel micro-fluidic chip, standardization of data acquisition is achieved, and the heterogeneity problem of a data source is solved.

The invention discloses a fresh commodity after-ripening regulation and control planning method oriented to maturity grading, and relates to the technical field of food science and biologication.The method comprises the steps that physiological parameters of fresh commodities are collected in real time based on a multi-modal sensor, and the physiological parameters comprise the epidermis pigment content, the ethylene release rate, the fruit hardness and the respiration intensity; the collected physiological parameters are input into a multi-objective optimization model based on deep learning, the model fuses a metabolic kinetic equation and an LSTM time sequence prediction algorithm, and a regulation and control parameter combination adaptive to the current mature stage is output; according to the regulation and control parameter combination, the temperature, the relative humidity and the O2 / CO2 concentration gradient of the controlled atmosphere storage equipment are synchronously regulated through a distributed control system, and a plant hormone antagonist is injected through an ultrasonic atomization device; and constructing a supply chain collaborative network based on a block chain technology, binding a grading result with logistics path planning, and adjusting a temperature control strategy and a shelf life countdown parameter of the cold chain transport vehicle in real time through an edge computing node.

This application discloses a rapid detection method for screening of dwarfism in children, which belongs to the field of intelligent medical technology. It includes the following steps: Step 1, accurately sampling through capillary effect, and automatically diluting the sample to ensure accurate concentration; Step 2, introducing the collected sample into a multi-channel microfluidic detection chip to achieve parallel quantitative detection of endocrine hormones; Step 3, real-time acquisition and amplification of weak biomolecule recognition signals to effectively improve the signal-to-noise ratio; Step 4, multi-dimensional analysis of the test results to achieve quantitative evaluation of growth and development, body mass index and sexual development indicators and risk prediction of endocrine diseases; Step 5, automatically integrating the analysis results and generating a standardized test report; Step 6, establishing a quality control mechanism throughout the entire detection process, including real-time monitoring of sample quality, tracking of detection process parameters, result consistency evaluation, and full traceability of detection data.

Provided herein are compounds, preferably thyroid hormone receptor beta (THR beta) agonist compounds, compositions thereof, and methods of their preparation, and methods of agonizing THR beta and methods for treating disorders mediated by THR beta.

The present invention discloses a compound represented by the following Formula (I) and a pharmaceutically acceptable salt thereof. The compound improves the THRα selectivity while maintaining good THRβ agonistic activity, thereby improving properties of the finished drug.

A method and apparatus for treatment of hypertension and heart failure by increasing secretion of endogenous atrial hormones by pacing of the heart. Pacing is done during the ventricular refractory period resulting in premature atrial contraction that does not result in ventricular contraction. Pacing results in the atrial wall stress, peripheral vasodilation, ANP secretion. Concomitant reduction of the heart rate is monitored and controlled as needed with backup pacing.

The invention relates to a skin care composition for improving female climacteric aging and application thereof, and the skin care composition for improving female climacteric aging comprises the following components: conotoxin peptide, bakuchiol, alfalfa extract and radix pseudostellariae extract, the weight ratio of the conotoxin peptide to the bakuchiol to the alfalfa extract to the radix pseudostellariae extract is (0.1-5): (0.1-3): (0.1-5): (0.1-3). By means of inhibiting neurotransmitters, regulating hormones and the like, skin health is enhanced, the problem of skin aging of menopause women is effectively solved, and the skin is tight and smooth.

The present invention addresses the problem of providing a novel compound that has a thyroid-stimulating hormone receptor antagonistic activity and is useful for the treatment of thyroid-related diseases. The present invention relates to a nitrogen-containing condensed ring compound represented by formula (A-I) or a pharmacologically acceptable salt thereof. The present invention relates to a nitrogen-containing condensed ring compound represented by formula (A-I) or a pharmacologically acceptable salt thereof. The compound or the pharmacologically acceptable salt thereof according to the present invention has an antagonistic activity against thyroid-stimulating hormone receptors and is therefore useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer) and others.

A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds and the pharmaceutical compositions containing them are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto. (I), (Ia)

The invention relates to the technical field of blood pressure dynamic monitoring systems, and provides an artificial intelligence-based blood pressure dynamic monitoring and risk assessment system, which comprises a patient terminal, a doctor terminal, a data center terminal, a local anomaly detection terminal and a strategy generation terminal, the patient terminal is used for collecting blood pressure, body position change and endocrine hormone fluctuation data of a patient in real time; the data center terminal is used for fusing, storing and processing the data uploaded by the patient terminal and performing overall risk assessment; the local anomaly detection terminal is used for collecting local blood flow rate and pulse wave conduction velocity data and carrying out local anomaly detection index analysis; the strategy generation terminal is used for generating strategy information according to the overall risk assessment result and the local anomaly detection index; and the doctor terminal is used for receiving and displaying the overall risk assessment result and the local anomaly detection index, and receiving and executing the strategy information. According to the invention, the comprehensiveness and timeliness of hypertension risk prediction and intervention are improved.

The invention provides a spleen and stomach conditioning factor lactobacillus reuteri obtained by fermenting poria cocos powder. The strain has good acid resistance, cholate resistance and antibacterial ability. The invention further provides a probiotic preparation which has an obvious effect on improving the spleen and the stomach. In addition, the invention also provides a composite preparation composition containing Lactobacillus reuteri, and the composition effectively promotes normal peristalsis and digestion and absorption functions of gastrointestinal tracts by regulating the secretion level of gastrointestinal hormones, enhances the immunity of the organism, protects intestinal mucosa barriers, comprehensively improves the symptoms of weakness of the spleen and the stomach, and improves the overall health level.

The invention discloses a pharmaceutical composition for promoting aTreg cell differentiation and application thereof, and relates to the field of biological medicine, and the pharmaceutical composition comprises zinc salt, a basic cell culture medium, fetal calf serum, antibiotic, L-glutamine and a pH buffer agent. According to the application, the basic cell culture medium is used for providing basic nutrition required by cell growth for lymphocytes, the fetal calf serum is used for providing growth factors, hormones, adhesion proteins and nutrient substances required by cell growth for the lymphocytes, and the antibiotics are used for preventing bacterial infection; l-glutamine provides key amino acid for cell energy metabolism and participates in synthesis of protein and nucleic acid, zinc salt provides zinc ions, and under the comprehensive action, the proportion of Treg cells and aTreg cells differentiated from lymphocytes in peripheral blood mononuclear cells is increased.

The present invention discloses a compound represented by the following Formula (I) and a pharmaceutically acceptable salt thereof. The compound improves the THRα selectivity while maintaining good THRβ agonistic activity, thereby improving properties of the finished drug.

The invention provides a lactobacillus plantarum MG360 with the efficacy of improving constipation, the preservation number of the lactobacillus plantarum MG360 is CGMCC NO 32953, and the lactobacillus plantarum MG360 is preserved in China General Microbiological Culture Collection Center on February 14, 2025. Meanwhile, the invention further provides a compound probiotic composition of the plant lactobacillus MG360 and the lactobacillus rhamnosus Eupro, the compound probiotic composition can be used for fermenting the coix seed enzymatic hydrolysate, and a fermentation product of the compound probiotic composition is rich in ferulic acid, vanillic acid, short-chain fatty acid, glutamic acid and the like. The fermentation product can obviously shorten the first black excrement discharge time of constipation mice, obviously improve the small intestine propulsion rate and the excrement water content, obviously improve the level of motility hormone (MTL, Gas, AchE, SP and 5-HT) in serum of the constipation mice and obviously reduce the level of inhibitory hormone (SS and VIP), and it is indicated that the fermentation product can relieve constipation by adjusting the gastrointestinal hormone peptide level. The preparation method of the probiotic preparation containing the plant lactobacillus MG360 and the compound probiotic fermentation preparation of the compound probiotic composition is simple, large-scale production can be achieved, and good application prospects are achieved.

The invention relates to the technical field of biology, in particular to application of a rice OsPBL8 gene in enhancing resistance of rice to magnaporthe oryzae. The rice OsPBL8 gene is a rice endogenous gene participating in the processes of plant growth and development, abiotic stress response, hormone signal channel regulation and control and the like. The invention provides application of the OsPBL8 gene in the field of disease resistance, the OsPBL8 gene is overexpressed through gene editing, and the expression quantity of receptor-like cytoplasm kinase OsPBL8 in plants is increased, so that a plurality of signal channels are regulated and controlled, and the germ resistance of the plants is synergistically improved. By adjusting key hub nodes of plant targeted immune signal transduction, more lasting broad-spectrum disease resistance can be provided, good universality is achieved, disease resistance and growth can be balanced, good practicability is achieved, and improvement of disease resistance of various rice varieties is facilitated.

The invention belongs to the technical field of biological agents, and particularly relates to ginsenoside variant flavobacterium DG-16 and application thereof in relieving continuous cropping obstacles of angelica sinensis and improving the quality of the angelica sinensis. According to the ginsenoside variant flavobacterium DG-16 disclosed by the invention, the growth of angelica sinensis is promoted by increasing the contents of jasmonic acid and cytokinin hormones, reducing the contents of gibberellin and salicylic acid hormones and promoting the circulation and utilization of nitrogen; in addition, the flavobacterium ginsenoside variant DG-16 can significantly increase the chlorophyll content, is beneficial to photosynthesis of the angelica sinensis, effectively changes the physiological and biochemical states of the angelica sinensis, can resist root rot of the angelica sinensis so as to relieve successive cropping obstacles and improve the quality, and has a significant effect.

The invention belongs to the technical field of biotechnology and botany, and particularly relates to a small peptide for improving abiotic stress tolerance of crops and application of the small peptide, and the small peptide is GhIDL02 and / or GhPIPL7. The amino acid sequence of the GhIDL02 is as shown in SEQ ID NO. 1; the amino acid sequence of the GhPIPL7 is as shown in SEQ ID NO. 2. According to the method, the small peptide GhIDL02 or GhPIPL7 is exogenously applied, so that the hormone-like effect is quickly exerted, the salt tolerance of the cotton is remarkably improved, and the adverse effect of a chemical regulating agent on the environment is avoided. Through a research technology combining bioinformatics and molecular biology, the positive regulation effect of the GhIDL02 and GhPIPL7 small peptides under salt stress is confirmed for the first time, and by activating an MAPK signal channel, the steady state of cotton sodium and potassium ions is maintained, the salt tolerance of cotton is improved, and a theoretical basis and technical support are provided for green development of an agricultural biotechnology.

The invention relates to the field of medical image processing, and discloses an AI auxiliary screening method based on a mammary gland molybdenum target image, and the method comprises the steps: obtaining time sequence image data containing a historical image and current hormone cycle phase information; predicting a basic evolution state representing the long-term trend of the organization through a long-term evolution network; predicting a physiological modulation vector representing a short-term physiological change through a physiological cycle network; generating an anti-fact image in combination with the basic evolution state and the physiological modulation vector; and carrying out pixel-level subtraction on the current real mammary gland molybdenum target image and the anti-fact image to generate an evolution deviation graph. The system comprises a data acquisition and registration module, a basic evolution state prediction module, a physiological modulation vector prediction module, an anti-fact image generation module and an evolution deviation graph generation module, and is used for executing the method. According to the method, physiological change and pathological evolution are effectively separated through decoupling modeling, and the accuracy of early abnormal evolution recognition is improved.

The invention relates to the technical field of microorganisms, and provides Witzia ciliaris KY009 (preservation number is CGMCC (China General Microbiological Culture Collection Center) NO. 33480) and Clostridium butyricum KY002 (preservation number is CGMCC NO. 33478), and the two strains are separated from an excrement sample. Experiments prove that the two strains can obviously improve the sperm quality and quantity, regulate the sex hormone level, improve the intestinal inflammation symptom and regulate the expression of related inflammatory factors. The invention also provides a composition containing the two strains, wherein the composition comprises a food composition, a pharmaceutical composition, a health-care product composition, a functional microbial agent and the like. The compositions are useful for improving reproductive health, modulating sex hormone levels, treating intestinal inflammation and promoting mucosal repair, and alleviating metabolic and immune related diseases. The strain and the composition provided by the invention have wide application prospects in the fields of medicines, foods and health-care products.

The invention provides an application of a lactobacillus paracasei IOB413 metagen in prevention of helicobacter pylori infection, and relates to the technical field of microorganisms. The lactobacillus paracasei IOB413 metaplasm can competitively occupy gastric epithelial cell adhesion sites to directly block the initial colonization of helicobacter pylori, so that infection preposed interception is realized, and the lactobacillus paracasei IOB413 metaplasm is suitable for early prevention of high-incidence people. The compound has dual mechanisms of site blocking and urease inhibition, and can cooperate with antibiotics to improve the eradication rate and reduce the drug resistance. Animal experiments show that the traditional Chinese medicine composition can reduce gastric mucosa proinflammatory factors in a dose-dependent manner, improve the activity of antioxidant enzymes, reduce lipid peroxidation products, relieve mucosa lesion, promote repair and reduce the risk of complications; moreover, gastrointestinal hormone disorder can be reversed, the digestive function is maintained, and related discomfort is relieved.

The present invention addresses the problem of providing a novel compound that has a thyroid-stimulating hormone receptor antagonistic activity and is useful for the treatment of thyroid-related diseases. The present invention relates to an N-substituted cyclic amide compound represented by the formula or a pharmacologically acceptable salt thereof. The compound or the pharmacologically acceptable salt thereof according to the present invention has a thyroid-stimulating hormone receptor antagonistic activity and is useful as a therapeutic agent for thyroid-related diseases (e.g., hyperthyroidism, Graves' disease, thyroid eye disease, and thyroid cancer) and others.

The invention provides a deuterium-labeled 3-indoleacrylic acid isotope compound and a preparation method thereof, and relates to the technical field of plant hormone detection, deuterated toluene is creatively nitrated and subjected to a ring closing reaction, then an aldehyde group is introduced, and finally hydrolysis is performed to obtain the target product deuterium-labeled 3-indoleacrylic acid isotope compound. The preparation method provided by the invention is strong in operability, relatively good in atom economy and excellent in reproducibility and stability, the isotope abundance of the prepared deuterium-labeled 3-indoleacrylic acid isotope compound can reach 98% or above, the chemical purity is 98% or above, and the deuterium-labeled 3-indoleacrylic acid isotope compound can be used as an internal standard substance for detecting plant hormones and has good application prospects. The method has important practical application value.

The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema.

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl) thieno[2,3-d]pyrimidine-2,4 (1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

The invention discloses a pregnancy-related monitoring system based on an electrochemical sensing technology, and the system comprises a wearable device which is used for obtaining hormone detection data of a target monitoring user; the server is connected to the wearable device and comprises a parameter analysis module and a scheme generation module, and the parameter analysis module is used for obtaining the hormone detection data and obtaining ovulation cycle parameters of the target monitoring user through analysis according to the hormone detection data; and the scheme generation module is used for generating a pregnancy-related guidance scheme corresponding to the target monitoring user according to a pregnancy-related target corresponding to the target monitoring user and the ovulation cycle parameter. Therefore, more intelligent and efficient pregnancy-related monitoring and guidance services can be realized, the monitoring accuracy of pregnancy-related indexes is improved, and better use experience is provided for users.

The invention discloses a composition containing D-chiro-inositol as well as a preparation method and application of the composition. The composition comprises D-chiro-inositol, Myo-inositol and microcapsule powder, wherein the wall material of the microcapsule powder consists of anhydride modified edible protein and a polysaccharide compound; the edible protein is selected from at least one of spirulina protein, quinoa protein, whey protein and soybean protein; the polysaccharide compound comprises at least one of fucoidin and larch arabinogalactan. Active components are also embedded in the microcapsule powder, and comprise at least one of Omega-3, coenzyme Q10, astaxanthin and vitamin. According to the composition, the stability and bioavailability of fat-soluble active ingredients are improved through microencapsulation, and the composition has a synergistic effect with components such as D-chiro-inositol and Myoinositol, so that insulin resistance is effectively improved, female hormone balance is adjusted, and polycystic ovarian syndrome is improved. The process is simple, is suitable for large-scale production, and can be widely applied to dietary supplements or functional foods.

Sublingual compositions for the treatment of erectile dysfunction (ED) comprise unique combinations of phosphodiesterase-type 5 (PDE5) inhibitors and D1 / D2 dopamine receptor agonists. In preferred embodiments, a combination of four drug actives exhibits a full range of effectiveness for ED in which there is a short and long acting PDE5 inhibitor in combination with both a dopamine agonist and a CNS hormone to provide both a physiological response and a psychological / CNS action. A treatment for ED comprises administration of sublingual compositions in the physical form of sublingual tablets.

Provided are a combination therapy comprising inavolisib, palbociclib and fulvestrant and methods of treating PIC3CA-mutant, hormone receptor positive (HR+) and HER2 negative (HER2-) locally advanced or metastatic breast cancer comprising administering a therapeutically effective amount of inavolisib, palbociclib and fulvestrant. The combination therapy produces a statistically significant and clinically meaningful improvement to the patient as compared to administering palbociclib and fulvestrant alone to a comparable patient.