13669results about How to "Good water solubility" patented technology

A high integrity liposome comprising at least one stabile lipid and at least one peptide-like therapeutic agent associated with said liposome, adapted for parenteral administration to an animal, including a human, and method according to manufacture and use. Immunizing dosage forms comprising a liposome and an immunogen, wherein said liposome and immunogen are present in an immunization dose. Additionally, a dosage form, including such form particularly adapted to producing an immune response, comprising a salt according to an organic acid derivative of a sterol and an immunogen wherein said organic acid derivative of a sterol and immunogen are present in an immunization dose, and method according to use is disclosed. Further, a dosage form, including such form particularly adapted to producing an immune response, comprising dimyristoylphosphatidylcholine (DMPC) / cholesterol liposomes, optionally in an aluminum hydroxide gel, and an immunogen wherein said DMPC / cholesterol and immunogen are present in an immunization dose, and method according to use.

This invention relates to novel pharmaceutically useful compositions that bind to a biological molecule, having improved circulatory half-life, increased avidity, increased affinity, or multifunctionality, and methods of use thereof. The present invention provides a pseudo-antibody comprising an organic moiety covalenty coupled to at least two target-binding moieties, wherein the target-binding moieties are selected from the group consisting of a protein, a peptide, a peptidomimetic, and a non-peptide molecule that binds to a specific targeted biological molecule. The pseudo-antibody of the present invention may affect a specific ligand in vitro, in situ and / or in vivo. The pseudo-antibodies of the present invention can be used to measure or effect in an cell, tissue, organ or animal (including humans), to diagnose, monitor, modulate, treat, alleviate, help prevent the incidence of, or reduce the symptoms of, at least one condition.

The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.

An encapsulation material, intended for use in encapsulated electrophoretic displays, comprises the coacervation product of a polyanionic polymer having a vinyl main chain and a plurality of anionic groups bonded to the main chain, with a cationic or zwitterionic water-soluble polymer capable of forming an immiscible second phase on contact with the polyanionic polymer.

Modified human growth hormone polypeptides and uses thereof are provided.

The present invention relates to prodrugs of modulators of ABC transporters, particularly, CFTR modulators, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

The invention relates to bifunctional stapled or stiched peptides comprising a targeting domain, a linker moiety, and an effector domain, that can be used to tether, or to bring into close proximity, at least two cellular entities (e.g., proteins). Certain aspects relate to bifunctional stapled or stiched peptides that bind to an effector biomolecule through the effector domain and bind to a target biomolecule through the targeting domain. Polypeptides and / or polypeptide complexes that are tethered by the bifunctional stapled or stiched peptides of the invention, where the effector polypeptide bound to the effector domain of the bifunctional stapled or stiched peptide modifies or alters the target polypeptide bound to the targeting domain of the bifunctional peptide. Uses of the inventive bifunctional stapled or stiched peptides including methods for treatment of disease (e.g., cancer, inflammatory diseases) are also provided.

Calcium-strontium-hydroxyphosphate (strontium-apatite-) cement preparations are described, comprising a powder mixture, which contains molar quantities of the components calcium (Ca), strontium (Sr) and phosphate (P) in the mixture in the ranges 1.00<Ca / P≦1.50 and 0<Sr / P<1.5, together with an alkali salt or an ammonium salt of phosphoric acid, and with water and / or an aqueous solution. The powder mixture particularly contains, as the Ca-component, Ca3(PO4)2 (TCP), and as the Sr-component SrHPO4 and / or Sr3(PO4)2 and optionally additional SrCO3. As the aqueous mixing solution for the formation of the strontium-apatite cement, an aqueous solution of an alkali salt or an ammonium salt of the phosphoric acid is suitable.

The invention discloses a particle-typed composite fertilizer of humic acid and manufacturing method, which consists of dressing and karyosome, wherein the dressing contains nitrogen, phosphor and potassium. The manufacturing method comprises the following steps: graining humic acid; cladding; graining; solidifying fused fertilizer on the particle of humic acid; making the composite fertilizer dissolved into water without falling; fitting for large scale of agricultural product.

A formaldehyde-free aqueous binder composition comprises a binder component (A) obtainable by reacting at least one alkanolamine with at least one carboxylic anhydride and, optionally, treating the reaction product with a base; and a binder component (B) which comprises at least one carbohydrate. The binder composition is particularly useful for bonding mineral fiber products.

Charged or pro-charged cross-linking moieties and conjugates of cell binding agents and drugs comprising the charged or pro-charged cross-linking moieties and method of making the same.

Described herein are nanoparticles that are coated with a bilayer of molecules formed from surface binding molecules and amphiphatic molecules. The bilayer coating self assembles on the nanoparticles from readily available materials / molecules. The modular design of the bilayer coated nanoparticles provides a means for readily and efficiently optimizing the properties of the bilayer coated nanoparticle compositions. Also described herein are uses of such nanoparticles in medicine, laboratory techniques, industrial and commerical applications.

The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.

Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and / or rebaudioside B and / or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.

The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting additional Factor XIa inhibitors using these structures.

The present invention relates to a water-soluble film, which is a polyvinyl alcohol film comprising a polyvinyl alcohol resin (A), wherein the water-soluble film has a time for dissolution in water at 20° C. of not more than 60 seconds in terms of a film thickness of 76 μm, a b-value of the film is not more than 0.5, and a b-value of the film after leaving at 80° C. for 72 hr is not more than 1.0, preferably a water-soluble film comprising: a polyvinyl alcohol resin (A); at least two kinds of plasticizers (B); and a sulfite salt (C), wherein the content of the plasticizer (B) based on 100 parts by weight of the polyvinyl alcohol resin (A) is 5 to 50 parts by weight and the content ratio of the sulfite salt (C) to the plasticizer (B) (C / B: weight ratio) is more than 0.02 and not more than 0.35. According to the invention, there is provided a water-soluble film comprising a PVA resin as a main component, wherein the film is less likely to cause coloration at the time of film formation and coloration with time even upon contact with a chemical.

A process for making a granulate composition suitable to the preparation of an oral solid form that can disintegrate rapidly inside the buccal cavity is provided as well as the granulate compositions and obtained.

The invention provides a functional oil microencapsulation and a manufacturing method thereof and relates to a microencapsulation, and the functional oil microencapsulation has the advantages of high stability and immobilized proteinaceous pellicle. The oil microencapsulation is prepared from the following raw materials: functional oil, plant oil, an antioxidant, aqueous-phase main-wall materials, aqueous-phase auxiliary-wall materials, bio-enzyme protein and water. The plant oil serving as a carrier is mixed with the functional oil, then the antioxidant is added, and then the materials are heated and dissolved in water bath, thus obtaining an oil-phase core material solution; the aqueous-phase main-wall materials and the aqueous-phase auxiliary-wall materials are added into deionized water, and then the materials are heated and dissolved in water bath, thus obtaining an aqueous-phase wall material solution; the oil-phase core material solution is added in the aqueous-phase wall material solution, the mixture is sheared and emulsified by a shearing machine, and then is homogenized by a homogenizer, thus obtaining a nanometer-level solution with uniform oil drop diameter; and bio-enzyme is added into the nanometer-level solution, the mixture is placed in hot-water bath for heating and stirring reaction, temperature is raised after the reaction so as to enable the bio-enzyme to be inactivated, and drying is carried out, thus obtaining the functional oil microencapsulation.

The invention discloses a high-efficiency multielement compound foliage selenium fertilizer which aims to increase selenium artificially. The high-efficiency multielement compound foliage selenium fertilizer comprises the following components: macroelements, medium elements, microelements, chelator, selenium, rare-earth elements, active organic substances, growth regulator and surfactant. The high-efficiency multielement compound foliage selenium fertilizer is especially suitable for producing selenium-rich tea, selenium-rich rice, selenium-rich corn and other selenium-rich agricultural products in low-selenium or selenium-deficient regions. The invention has the advantages of favorable raw material compatibility, scientific proportion, scientific technique and diversified and compounded nutrient elements, and can effectively solve the nutrient deficiency symptom of the crop, thereby achieving the goal of sufficiently supplementing insufficient soil nutrients.

The present invention aims to provide a supporting material for supporting the shape of a photofabrication model on photofabrication in ink-jet three dimensional printing method in which the photocured product is excellent in solubility in water and is easy to remove after photofabrication, and the like. A modeling material for forming a photofabrication model in ink-jet three dimensional printing method containing a curable resin component with a weighted average of SP value of 9.0 to 10.3; and a supporting material for supporting the shape of a photofabrication model on photofabrication in ink-jet three dimensional printing method containing a water-soluble monofunctional ethylenically unsaturated monomer (F), polyoxypropylene glycol with a number average molecular weight of 100 to 5,000 and / or water (G), and a photopolymerization initiator (D).

The invention describes a new calcium phosphate cement powder, whose composition can best be described over the Ca / P molar ratio range of 1.35 to 1.40, most preferably 1.39, and whose two components were prepared by wet chemical synthesis procedures. One component is chemically-synthesized, bi-phasic alpha-TCP (Ca3(PO4)2, 95 wt %)+HA (Ca10(PO4)6(OH)2, 5 wt %) powder, while the second component is again a chemically-synthesized, single-phase DCPD (CaHPO4·2H2O) powder. A setting solution (Na2HPO4·2H2O) is used to form a self-setting calcium phosphate cement from the powder mixture. This cement can be used as bone filler or bone substitute in applications, which require higher rates of resorption.

The present invention is directed to novel therapeutic compounds comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. These high therapeutic index derivatives have the same utility as the drug from which they are made, and they have enhanced pharmacological and pharmaceutical properties. In fact, the novel drug derivatives of the present invention enhance at least one therapeutic quality, as defined herein. The present invention is also directed to pharmaceutical compositions containing same.