551 results about "Amino acid composition" patented technology

Compositions and methods for administering ketone bodies to a subject include beta-hydroxybutyrate complexed with or coupled to at least one amino acid. The compositions and methods cause one or more of: weight loss, weight maintenance, reduced blood glucose level, maintenance of blood glucose level, increased muscle and physical performance, enhanced metabolic and cellular repair, improved detoxification and gut health, targeted bioavailability, sustained release and controlled absorption, increased metabolic efficiency, enhanced cellular uptake, minimized side effects, multifunctional therapeutics, improved focus, improved energy, improved cognitive function, improved mental acuity, treatment of traumatic brain injury, treatment of diabetes, treatment of neurological disorder, treatment of cancer, treatment of inflammatory condition, appetite suppression, anti-aging effects, anti-glycation effects, treatment of epilepsy, treatment of depression, improved performance, improved muscle mass, improved motor function, increased strength, increased metabolism, increased fat loss, increased fat oxidation, improved body composition, and improved mood.

The invention belongs to the technical field of biological medicines, and relates to an antibacterial polypeptide, a composition and application thereof. The amino acid sequence of the antibacterial polypeptide is as shown in SEQ ID NO. 1: KWKIKWPVKWFKM-NH2. The invention also discloses a preparation method of the antibacterial polypeptide. Experiments show that the antibacterial polypeptide disclosed by the invention has broad-spectrum antibacterial activity on gram-positive bacteria and / or gram-negative bacteria, and also has low cytotoxicity and low hemolysis. The antibacterial polypeptide provided by the invention consists of 14 amino acids, is relatively short in peptide chain, small in molecular weight and easy to artificially synthesize, is a micromolecular polypeptide with extremely high application value, can be used for preparing a novel antibacterial agent, and has a wide application prospect.

The invention provides copper-loaded duck-origin lactobacillus plantarum with high antibacterial peptide yield and application of the copper-loaded duck-origin lactobacillus plantarum. The preservation number of the provided copper-loaded duck-origin lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) NO.32835. The domesticated and bred duck-origin lactobacillus plantarum with high antibacterial peptide yield can tolerate high-concentration copper ions, the domesticated and bred lactobacillus plantarum can stably grow, and the contents of antibacterial peptide, extracellular protein, lipase, amylase, lactic acid, acetic acid and the like in the domesticated and bred lactobacillus plantarum strain are increased; and the amino acid composition is changed. The strain can convert inorganic copper into organic copper, the utilization rate of copper is increased, and growth and development of organisms are promoted. Moreover, small peptides and extracellular proteins in metabiotics generated after fermentation have the effect of effectively inhibiting harmful bacteria such as riemerella anatipestifer, escherichia coli, salmonella and staphylococcus of poultry, and are beneficial to eliminating intestinal inflammatory factors, maintaining intestinal health and improving the feed utilization rate.

The invention provides a micromolecular recombinant XVII type collagen as well as a preparation method and application thereof, and relates to the technical field of protein engineering. The novel recombinant human XVII type collagen is obtained by optimizing and screening a plurality of spiral region sequences such as a collagen structural domain, a C-terminal region and a middle region of the human XVII type collagen. The amino acid composition of the recombinant XVII type collagen is consistent with that of a natural collagen alpha1 chain, immunological rejection is not generated when the recombinant XVII type collagen is applied to a human body, the recombinant XVII type collagen can be widely applied to surgical medical treatment and medical beauty industries, the molecular weight of the collagen is small, efficient secretion soluble expression in eukaryotic host cells such as pichia pastoris can be achieved, and the recombinant XVII type collagen has a good application prospect. And industrial large-scale production is carried out. According to the present invention, the verification results show that the micromolecular recombinant XVII type collagen further has basement membrane anti-aging activity, wherein the basement membrane anti-aging activity specifically comprises the improvement of the expression levels of the IV type collagen, the VII type collagen and the XVII type collagen;

The invention provides an amino acid frosted cleaning composition as well as a preparation method and application thereof. The amino acid frosted cleaning composition comprises a surfactant, an amino acid composition, a thickening agent, a humectant, an antioxidant, a pH regulator and water, the surfactant is a combination of cocoyl glycinate, cocamidopropyl hydroxy sulfobetaine, sodium cocoyl methyl taurine taurate, sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium and glycolipid. According to the invention, a mild surfactant system with amino acid as a main component is adopted, so that the shampoo has rich and fine foam, quick foaming performance and easy washing performance, and the skin feeling is smooth and soft after washing. In addition, the system contains suspended crystal frosted particles formed by self-assembly of the amino acid composition, the appearance is novel, the better efficacy performance is achieved, and meanwhile the cleaning effect and the use comfort are improved.

The invention provides a bionic antibacterial peptide, a pharmaceutical composition, application of the bionic antibacterial peptide in preparation of antibacterial drugs and a design method of the bionic antibacterial peptide. A plurality of compounds are used for carrying out N-terminal modification on a polypeptide sequence consisting of 20 natural amino acids, so that a novel antibacterial peptide with a bionic function is generated, and the designed bionic antibacterial peptide is screened by adopting a method based on deep learning and experimental interaction. Compared with traditional drug screening, consumed time, manpower, material resources and financial resources are greatly reduced, the designed novel bionic antibacterial peptide has good biocompatibility, a functional group modified at the N end of the novel bionic antibacterial peptide can activate the self-assembly activity of polypeptide and help the polypeptide target a bacterial membrane, bacterial drug resistance is not likely to be caused, and the novel bionic antibacterial peptide has good application prospects. The drug-resistant bacteria can be effectively killed, the sterilization speed is higher, and potential and wide application prospects are achieved in clinical treatment of bacteria and drug-resistant bacteria infection diseases.

The invention relates to the field of food, and provides a soybean protein product and a preparation method thereof.The method comprises the steps that soybean and water are subjected to pulp grinding and centrifugal treatment, and residue-removed soybean milk and soybean residues are obtained; performing cold precipitation and centrifugal treatment on the residue-removed soybean milk to obtain a cold precipitation precipitate and a cold precipitation supernatant; carrying out ultrafiltration treatment on the cold precipitation supernatant, and collecting retentate; respectively drying the cold precipitation precipitate and the intercepted substance to obtain a cold precipitation dried substance and an intercepted dried substance; and carrying out mixing treatment on the cold-precipitated dried substance and the intercepted dried substance to obtain the soybean protein product. The soybean protein product prepared by the method contains all amino acids essential to human bodies, the proportion of the amino acids is close to that of ideal amino acids, and the nutritional value is high. Moreover, the method is simple and convenient to operate, low in cost and suitable for large-scale production.

The invention relates to the technical field of molecular biology, and discloses application of TaPSY5 small peptide and a coding gene thereof in promoting plant root growth. A tyrosine sulfated polypeptide is named as TaPSY5 small peptide and is as follows: (a) mature small peptide composed of 18 amino acids shown in a sequence 1 in a sequence table and having tyrosine sulfated modification; the TaPSY5 small peptide precursor protein is the following (b) or (c): (b) a protein composed of amino acids as shown in a sequence table 2; and (c) a protein derived from the amino acid of the sequence 2 in the sequence table through deletion / or substitution / or insertion of one or more amino acids. The TaPSY5 small peptide is externally applied, so that the growth rate of a plant root system can be increased. The gene (TaPSY5 gene) for coding the TaPSY5 precursor small peptide also belongs to the protection range of the invention. The invention also protects that the TaPSY5 gene is introduced into a target plant, and lateral roots and main roots of the obtained transgenic plant are significantly more than those of the target plant.

The design consists of a rectangular shape on the left side, excluding the dotted lines; in the center of the drawing, there is an arched window-shaped feature with a curved upper portion; floral patterns are arranged along the border of the arched window, and a cow's face is depicted at the bottom of the drawing; the nutrition facts and full amino acid in the drawing form no part of the claimed design.

Borylated Amino Acid compositions comprising tyrosine derivatives BTS and BTS(OMe) and novel methods of making BTS and BTS(OMe) are disclosed herein. Consequently, the BTS and / or BTS(OMe) can be scaled up to commercial scale and administered to patients as a Neutron Capture Agent and provide a method of treating cancer, immunological disorders, and other disease by utilizing a Neutron Capture Therapy modality.

The invention discloses a nanorana alpine antioxidative peptide and application thereof. The antioxidative peptide is a cyclic peptide composed of 29 amino acids, the amino acid sequence of the antioxidative peptide is as shown in SEQ ID NO.1, and cysteine at the seventh position and cysteine at the twelfth position form an intramolecular disulfide bond. The invention further discloses nucleotide for coding the antioxidative peptide of the nanorana pleskei. The antioxidative peptide has good anti-inflammatory and anti-oxidation effects, can protect plasmid DNA damaged by H2O2, inhibits accumulation of CuSO4 induced zebrafish larva active oxygen and migration of neutrophil, and relieves mouse skin injury induced by UVB radiation.

The invention discloses a peptidomics-based computer-aided rapid screening method, collagen antifreeze peptide and application thereof, and relates to the fields of food biotechnology and bioinformatics. The amino acid sequence of the collagen antifreeze peptide is as shown in any one of SEQ ID NO.1-5. The invention provides a computer-aided antifreeze peptide rapid screening method based on peptiomics, which comprises the following steps: performing peptiomics analysis on a cod collagen hydrolysate containing a large amount of polypeptide, and screening the antifreeze peptide according to physicochemical properties, amino acid composition of a primary structure and a molecular docking result of the cod collagen hydrolysate. The interaction capability of the cod collagen hydrolysate and the ice crystals is scored in multiple aspects, so that the antifreeze peptide with strong interaction capability with the ice crystals is rapidly screened. The antifreeze peptide provided by the invention can form a plurality of hydrogen bonds with ice crystals, has extremely strong action capacity with the ice crystals, can be used for preparing an antifreeze agent, and is further applied to frozen surimi products.

The invention discloses a saline-alkali soil rhizosphere microdomain soil improvement and fertilization fertilizer and a preparation method thereof, and belongs to the technical field of saline-alkali soil treatment. The fertilizer is composed of a microbial inner core, a slow release fertilizer secondary outer layer and a soil conditioner outer layer, the microbial inner core is composed of a compound microbial agent (composed of nitrogen-fixing bacteria, phosphate solubilizing bacteria and live potassium bacteria), biochar and a polymer organic membrane material, the slow release fertilizer secondary outer layer is composed of a chemical fertilizer, an inhibitor (a nitrification inhibitor and / or a urease inhibitor) and amino acid, and the soil conditioner outer layer is composed of a soil conditioner outer layer. The soil conditioner outer layer is composed of a soil conditioner special for saline-alkali soil improvement. The method has the beneficial effects that (1) the pH value of the soil is adjusted and the soil structure is improved, so that the microbial flora can better adapt to the soil environment of the saline-alkali soil; and (2) the biochar and the isolating membrane effectively protect the activity of microorganisms, and the microorganisms are released when the pH value and the salt-based ions of the soil around the rhizosphere reach a lower level, so that the saline-alkaline obstacle of the growth of the microorganisms is overcome.

The invention provides a composition and application thereof in cosmetics, and belongs to the technical field of cosmetics. The composition comprises hexapeptide and a lavender extract in a mass ratio of (10 mg): (10-1000 mg): 0.1 kg. And the amino acid composition of the hexapeptide is glycine-proline-glutamic acid-glycine-proline-glutamic acid. The composition has the effect of simultaneously increasing expression of skin collagen XVII, collagen IV, elastin, aquaporin AQP3 and nighttime protein, so that the anti-aging effect can be achieved.

The invention provides an amino acid water-soluble fertilizer as well as a preparation method and application thereof, and relates to the technical field of amino acid water-soluble fertilizers. The amino acid water-soluble fertilizer comprises compound amino acid, a microbial fermentation product, inorganic salt, a surfactant, a dispersing agent and a preservative, the microbial fermentation product is obtained by aerobic fermentation of radix puerariae and rhizoma atractylodis through a complex microbial inoculant; the compound amino acid is composed of animal protein hydrolyzed amino acid and vegetable protein hydrolyzed amino acid. According to the water-soluble fertilizer disclosed by the invention, through the synergistic interaction of the compound amino acid and the microbial fermentation product, multi-objective optimization of nutrition supply, stress resistance regulation and metabolism enhancement is realized, the yield and the quality of crops are remarkably improved, an efficient and environment-friendly solution for increasing the yield and improving the quality is provided for the crops, and the water-soluble fertilizer has a remarkable agricultural application value.

Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3−).

The invention belongs to the field of veterinary drugs, and particularly relates to a medicine for improving immunity of bred animals. The medicine provided by the invention comprises the following active ingredients in parts by weight: 10-20 parts of withered grass 37 peptide and extracts of the following traditional Chinese medicinal materials: 15-30 parts of wintercreeper, 15-30 parts of astragalus membranaceus, 15-30 parts of spirulina, 10-20 parts of silybum marianum and 10-20 parts of herba epimedii. Wherein the withered grass 37 peptide is a biological active peptide with an anti-infection function, is composed of a plurality of amino acids and has broad-spectrum antibacterial activity. The medicine provided by the invention has the functions of inhibiting and sterilizing, regulating immunity and regulating body functions so as to improve the immunity of bred animals, thereby turning pathogenesis and ensuring the health of the bred animals. A curative effect experiment shows that the medicine can improve the growth performance of bred animals and effectively reduce breeding loss, has the advantages of being environmentally friendly, safe and capable of preventing diseases, and has a good market prospect.

The invention provides a method for simultaneously detecting at least two of cysteine, acetylcysteine and cystine or salts of amino acids in an amino acid composition. High performance liquid chromatography is adopted for detection, and chromatographic conditions comprise that octadecylsilane chemically bonded silica is adopted as a chromatographic column of a filler, and a mobile phase A and a mobile phase B are adopted for gradient elution; wherein the mobile phase A is a mixed solution of an ammonium sulfate solution and an ion pair reagent. According to the method disclosed by the invention, cysteine, acetylcysteine, cystine or salts of the amino acids in the amino acid composition can be separated from one another and can be effectively separated from other amino acid components or impurities, and the separation degree is high; cysteine, cystine and acetylcysteine in the reference substance and amino acid composition are stable in retention time and good in peak shape. The method provided by the invention has the advantages of strong specificity, good stability, high accuracy, accurate, reliable and effective detection result, good repeatability and high precision.

The invention belongs to the technical field of food flavor engineering, and discloses a Maotai-flavor Baijiu flavor composite essence based on a non-volatile substance release promoting effect, and the composite essence is composed of a volatile aroma substance, a non-volatile organic acid and an amino acid. Aiming at the technical bottlenecks of rapid attenuation of aroma intensity of volatile components and single flavor dimension in the existing Maotai-flavor Baijiu flavor compound essence blending technology, the invention creatively constructs a molecular synergistic system of volatile and non-volatile flavor components. By adding non-volatile substances, the effect of enhancing the flavor of the Maotai-flavor Baijiu flavor composite essence is achieved. The technology not only completely reproduces the flavor structure of the traditional solid-state fermented Maotai-flavor liquor, but also endows the compound liquor and flavor foods (such as Maotai-flavor baked products, compound seasonings and non-alcohol ready-to-drink beverages) with a continuous and stable aroma releasing characteristic, and provides a molecular-level regulation and control scheme for upgrading the sensory quality of liquor flavor standardization and food industrial production.

The invention discloses a method for impregnating coffee beans with fructose under the assistance of ultrasonic waves, and relates to the technical field of food processing, and the method is technically characterized by comprising the following steps: selecting Robursta coffee beans with the moisture content of 10-12%; mixing with a 5% fructose solution according to a solid-liquid ratio of 1: 4, treating for 5-20 minutes (preferably 5 minutes) under ultrasonic waves of 40 kHz and 120 W, and totally impregnating for 4 hours; performing forced air drying at 40 DEG C for 23h until the water content is 10- And baking at the temperature of 175 DEG C for 7-8 minutes. A honeycomb net structure is formed on the surface of the coffee beans through ultrasonic treatment, the total sugar content is remarkably increased to 54.65 mg / g, amino acid composition is affected, and bioactive substances such as polyphenol and flavone are increased. The score of the baked coffee beans is more than 72 (the score of the coffee beans is 74.92 after the coffee beans are subjected to ultrasonic treatment for 5 minutes) through an SCA cup test, and the coffee beans have caramel fragrance, nut fragrance and smoother mouth feel. The method is simple and convenient to operate, low in cost and capable of effectively improving the flavor quality of the Robursta coffee.

The invention relates to the technical field of biological medicines, and discloses a polypeptide for treating osteoarthritis by aiming at AHR (Aryl Hydrocarbon Receptor), the amino acid sequence of the polypeptide is GFQQSDVIHQSVYELISINHTEDRA, and the amino acid sequence of the polypeptide is GFQQSDVIHQSVYELISINHTEDRA, and the amino acid sequence of the polypeptide is GFQQSDVIHQSVYELISINHTEDRA. The polypeptide is prepared by a solid-phase polypeptide synthesis method; the solid-phase polypeptide synthesis method specifically comprises the following steps: synthesizing from a C end to an N end, connecting a carboxyl group of a first amino acid to insoluble resin, then adding other amino acids one by one to form a peptide chain, and carrying out protection and deprotection reactions of a side chain in each step. The polypeptide is composed of natural amino acids and has good biocompatibility and degradability, and experimental results show that no obvious toxic reaction occurs in the cell level and the animal level, so that the polypeptide has conditions for further development of pharmacokinetic research and preclinical tests, and a feasible basis is provided for conversion to clinical application.

The invention discloses an amino acid composition for treating alopecia and application of the amino acid composition in preparation of a medicine for treating alopecia, and belongs to the field of medicine configuration products, the amino acid composition is composed of a targeting core intervention component and an auxiliary strengthening synergistic component, the targeting core intervention component is prepared from 30-50 parts of arginine, 50-155 parts of lysine and 50-120 parts of glutamic acid, and the auxiliary strengthening synergistic component is prepared from an auxiliary strengthening synergistic component and an auxiliary strengthening synergistic component. 10 to 40 parts of cysteine and 20 to 60 parts of leucine; the auxiliary strengthening synergistic component is prepared from 15 to 45 parts of tyrosine, 15 to 40 parts of glycine, 10 to 40 parts of glutamine, 20 to 35 parts of serine, 5 to 25 parts of alanine, 2 to 20 parts of aspartic acid and 15 to 35 parts of phenylalanine; the composition can be used as an active ingredient to be prepared into different dosage forms such as a pigmentum, a spray, an ointment and a liniment, is applied to prevention of alopecia and promotion of hair growth, and has a remarkable treatment effect.

This invention discloses a soil improvement and fertilization fertilizer for rhizosphere micro-domains in saline-alkali land and its preparation method, belonging to the field of saline-alkali land management technology. The fertilizer consists of a microbial core, a slow-release fertilizer sub-outer layer, and a soil conditioner outer layer. The microbial core is composed of a compound microbial agent (composed of nitrogen-fixing bacteria, phosphate-solubilizing bacteria, and potassium-active bacteria), biochar, and a high-molecular organic membrane material. The slow-release fertilizer sub-outer layer is composed of chemical fertilizers, inhibitors (nitrification inhibitors and / or urease inhibitors), and amino acids. The soil conditioner outer layer is composed of a soil conditioner specifically for saline-alkali land improvement. The advantages of this invention are: (1) it first adjusts the soil pH and improves the soil structure, so that the microbial community can better adapt to the soil environment of saline-alkali land; (2) the biochar and the isolation membrane effectively protect the microbial activity, and release the microorganisms when the soil pH and base ions around the rhizosphere reach a low level, overcoming the saline-alkali barrier to microbial growth.

The invention discloses a litchi disease-resistant gene LcEXP1 and an application thereof. The litchi disease-resistant gene LcEXP1 is separated from litchis, the full-length cDNA (complementary deoxyribonucleic acid) of the gene is 750bp, and the encoded protein is an expansion protein with the full length consisting of 250 amino acids. The litchi disease resistance related gene LcEXP1 is transiently expressed in tobacco, different tobacco leaves are inoculated with phytophthora capsici and alternaria alternata after two days, it can be observed that after expression of the LcEXP1, scabs are remarkably reduced compared with negative control, and biostatistical analysis shows that the areas of the two treated scabs are remarkably different. Therefore, the gene can effectively promote the disease resistance of plants such as tobacco and the like, and has a wide application prospect in developing products for improving the disease resistance of the plants.

The invention relates to the technical field of biology, in particular to application of an StDnaj gene to improvement of salt tolerance of potatoes. The protein disclosed by the invention is shown in (a) or (b); (a) a protein composed of amino acids as shown in SEQ ID NO.1; and (b) a derivative protein which is obtained by substitution and / or deletion and / or addition of one or more amino acid residues on the amino acid sequence shown as SEQ ID NO.1 and has the same function. The salt tolerance function of the StDnaj gene and the StDnaj protein coded by the StDnaj gene in plants is proposed and verified for the first time, the StDnaj gene and the StDnaj protein can be applied to salt-resistant breeding and variety improvement of potatoes, and more choices are provided for potato resistance breeding.

The invention relates to the technical field of amino acid compositions, and discloses a compound amino acid composition for enhancing telomerase activity, which comprises the following components (by weight): 20-25 parts of L-arginine; 15 to 20 parts of L-lysine; 25 to 30 parts of L-glutamine; 10 to 15 parts of L-serine; 5 to 8 parts of L-glycine; 3 to 5 parts of L-proline; 2 to 4 parts of N-acetyl-L-cysteine; 1 to 2 parts of L-tryptophan; 1 to 2 parts of beta-alanine; 2 to 3 parts of L-carnitine; 1-2 parts of taurine; through the synergistic effect of multiple mechanisms, the compound amino acid composition not only significantly enhances the telomerase activity (up to 195%), but also can maintain the telomere length, inhibit cell aging and provide antioxidant protection. The comprehensive regulation effect is derived from a unique metabolic network formed among the components, and mutual promotion and regulation are realized. Experimental results show that the long telomere length (8.3 kb vs control group 7.1 kb) can be maintained in 30-day long-term culture.

The invention provides low-beany-flavor bean flour and a preparation method of low-beany-flavor soybean formula nutrition powder, belongs to the field of food processing, and particularly relates to the preparation method of the low-beany-flavor soybean formula nutrition powder. By providing the low-beany-flavor bean flour and the preparation method of the low-beany-flavor soybean formula nutrition powder, the problems that existing soybean formula nutrition powder is inharmonious in amino acid composition, single in nutrition composition, serious in beany flavor and the like are solved. The soybean formula nutrition powder with low beany flavor and balanced nutrition provided by the invention ensures that an organism obtains comprehensive and balanced amino acid combinations, vitamins, minerals and polyunsaturated fatty acids, and the sensitization is also greatly reduced.

The invention discloses a pathogenicity-related sclerotinia sclerotiorum gene SsVSP19 and application thereof, and belongs to the technical field of microbial genetic engineering, the pathogenicity-controlling gene SsVSP19 from sclerotinia sclerotiorum provided by the invention has a DNA sequence as shown in SEQ ID No: 1, and consists of 1298 nucleotides; the amino acid sequence of the protein coded by the provided SsVSP19 gene is as shown in SEQ ID No: 2, and the protein consists of 332 amino acids; the SsVSP19 gene can be applied to the field of plant sclerotinia sclerotiorum gene engineering. The gene SsVSP19 for controlling pathogenicity of sclerotinia sclerotiorum is knocked out, so that the pathogenicity of the gene SsVSP19 has defects, and the gene SsVSP19 can be applied to reducing the pathogenicity of sclerotinia sclerotiorum.

Methods of improving athletic performance in a human, increasing the bioabsorption of the compound in a human, or of increasing the vasodilative characteristics in a human comprise administering to the human compositions and supplement formulations comprising a compound selected from the group consisting of Carnitine, Taurine, and derivative forms thereof; and a Nitrate are disclosed.

Methods of improving athletic performance in a human, increasing the bioabsorption of the compound in a human, or of increasing the vasodilative characteristics in a human comprise administering to the human compositions and supplement formulations comprising a compound selected from the group consisting of Carnitine, Taurine, and derivative forms thereof; and a Nitrate are disclosed.