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1349 results about "Amino acid composition" patented technology

Amino acids are organic compounds composed of nitrogen, carbon, hydrogen and oxygen, along with a variable side chain group. Your body needs 20 different amino acids to grow and function properly. Though all 20 of these are important for your health, only nine amino acids are classified as essential (1).

Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components

A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a reactive group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.
Owner:CONJUCHEM

Modified nucleoside, nucleotide, and nucleic acid compositions

The present disclosure provides, inter alia, formulation compositions comprising modified nucleic acid molecules which may encode a protein, a protein precursor, or a partially or fully processed form of the protein or a protein precursor. The formulation composition may further include a modified nucleic acid molecule and a delivery agent. The present invention further provides nucleic acids useful for encoding polypeptides capable of modulating a cell's function and / or activity.
Owner:MODERNA THERAPEUTICS INC

Whey protein product and a method for its preparation

The invention relates to a whey protein product having a ratio of whey protein to casein in the range from about 90:10 to about 50:50 and the total protein content of at least 20% on dry matter basis, and a method for its preparation. The product has a favourable amino acid composition and is especially suitable for athletes.
Owner:VALIO OY

Regulation of mammalian keratinous tissue using N-acyl amino acid compositions

InactiveUS20050019356A1Prevent and retardTreat uneven skin toneCosmetic preparationsToilet preparationsPlant sterolHydroxyproline
Skin care compositions containing N-acyl amino acid, particularly N-acyl derivatives of Phenylalanine or Tyrosine, their isomers, or their salts; at least one other skin care active selected from sugar amines, vitamin B3, retinoids, peptides, dialkanoyl hydroxyproline, hexamidine, salicylic acid, and phytosterol; and a dermatologically acceptable carrier for the N-acyl amino acid and the skin care active. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the skin care composition of the invention.
Owner:THE PROCTER & GAMBLE COMPANY

Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use

InactiveUS7163802B2Accurate and robust calibration setTherapeutic utilityPeptide/protein ingredientsDisease diagnosisRetention timeLinear relationship
The present invention provides processes for determining the molecular weight of glatiramer acetate and other copolymers. The present invention further provides a plurality of molecular weight markers for determining the molecular weight of glatiramer acetate and other copolypmers which display linear relationships between molar ellipticity and molecular weight, and between retention time and the log of the molecular weight. The molecular weight markers also optimally demonstrate biological activity similar to glatiramer acetate or corresponding copolymers and can be used for treating or preventing various immune diseases. In addition, the subject invention provides pharmaceutical compositions for the treatment of immune diseases comprising a polypeptide having an identified molecular weight and an amino acid composition corresponding to glatiramer acetate or a terpolymer.
Owner:YEDA RES & DEV CO LTD

Methods and devices for using Raman-active probe constructs to assay biological samples

Various methods of using Raman-active or SERS-active probe constructs to detect analytes in biological samples, such as the protein-containing analytes in a body fluid are provided. The probe moieties in the Raman-active constructs are selected to bind to and identify specific known analytes in the biological sample or the probe moieties are designed to chemically interact with functional groups commonly found in certain amino acids so that the invention methods provide information about the amino acid composition of protein-containing analytes or fragments in the samples. In some cases, the Raman-active or SERS-active probe constructs, when used in the invention methods, can identify particular protein-containing analytes or types of such analytes so that a protein profile of a patient sample can be made. When compared to a data base of Raman or SERS spectra of normal samples, a disease state of a patient can be identified using the methods disclosed.
Owner:INTEL CORP

Polymer micelle medicine carrying system using amino acid as stabilizing agent

The invention relates to a polymer micelle medicine carrying system using an amino acid as a stabilizing agent and a preparation method thereof, wherein the medicine carrying system can be used as a medicament carrier composition, and the medicament carrier composition comprises an amphipathic segmented copolymer and amino acid, wherein the amphipathic segmented copolymer comprises a diblock copolymer and a triblock copolymer, the amino acid is selected from 20 kinds of common amino acid, and the mixture ratio (w / w) of the amphipathic segmented copolymer to the amino acid is 100 / 0.01-1.00 / 99.99.
Owner:FANTAI INST OF CHEM MEDICINES NANJING

Docetaxel polymeric micelle medicine composition taking amino acid as stabilizing agent

The invention relates to polymeric micelle medicine carrying system taking amino acid as stabilizing agent and a preparation method thereof. The medicine carrying system can be acted as a medicine carrying composition which is composed of amphipathy block copolymer and amino acid; wherein the amphipathy block copolymer comprises diblock copolymer and triblock copolymer, amino acid is selected from twenty common amino acids, the ratio (w / w) of amphipathy block copolymer and amino acid is 100-1.00: 0.01-99.9.
Owner:FANTAI INST OF CHEM MEDICINES NANJING +2

Detergent composition containing amino acid component for washing fruits, vegetables and dishes

The present invention relates to a detergent composition containing an amino acid component for washing fruits, vegetables and dishes, which comprises the following components of an anionic surfactant, a non-ionic surfactant, an amphoteric surfactant, amino acid, a viscosity modifier, a chelating agent, an antiseptic, a light stabilizer, an antioxidant, a flavor and deionized water. The amino acid composition is one or a mixture with more than two of alanine, arginine, asparagine, aspartic acid, cystine, glutamine, glutamic acid, leucine, lysine, methionine, phenylalanine, prolinol acid, serine, threonine, glycine, histidine, isoleucine, tryptophan, tyrosine and valine. The detergent of the invention can maintain good decontamination capability, improve the feeling when the detergent composition is used, reduce the hands skin irritation and enhance the hand skin moisturizing ability to improve dry feeling.
Owner:GUANGZHOU LIBY

Amino acid composition

An amino acid composition comprising the following amino acids at the following molar ratio: proline (12.6 to 23.4), alanine (8.4 to 15.6), glycine (13.3 to 24.9), valine (8.2 to 15.4), threonine (5.0 to 9.4), eucine (4.3 to 8.1), histidine (1.8 to 11.9), serine (1.7 to 3.3), lysine (6.0 to 11.2), isoleucine (3.1 to 5.9), glutamic acid (2.2 to 10.4), arginine (2.4 to 4.6), phenylalanine (2.6 to 5.0), tyrosine (4.2 to 7.8) and trypsin (1.5 to 2.9). The composition supplements blood amino acids reduced during hard exercise and shows effects to improve motor function, to reduce fatigue after exercise and to help recovery from the fatigue.
Owner:THE INST OF PHYSICAL & CHEM RES WAKO +1

Dipeptide boric acid composed of carboxylic acid and alpha-amino acid as well as ester compound thereof, and preparation method and application of dipeptide boric acid and ester compound thereof

The invention belongs to the field of drug synthesis and in particular relates to a series of novel peptide boric acids as well as an ester compound or pharmaceutical salt thereof, and a preparation method and application of the peptide boric acids as well as the ester compound or pharmaceutical salt thereof in pharmacodynamics. A structure of the peptide boric acid and the ester compound or pharmaceutical salt thereof is shown in a formula I (described in the specification). The compound provided by the invention can be used for preparing a proteasome inhibitor and can further be used for treating solid tumours and blood tumours, wherein the solid tumours are selected from non-small cell lung cancer, small cell lung cancer, lung adenocarcinoma, lung squamous carcinoma, pancreatic cancer, breast cancer, prostate cancer, liver cancer, skin cancer, epithelial cell cancer, gastrointestinal stromal tumor, nasopharynx cancer and leukemia; and the blood tumours are selected from multiple myeloma, mantle cell lymphoma and histiocytic lymphoma.
Owner:JIANGSU CHIA TAI FENGHAI PHARMA

Composition of amino acid

An amino acid composition with high nutrition supporting effect is composed of acetylcysteine, acetyltyrosine and tryptophan in weight ratio of (0.81-2): (0.81-2): (0.9-1.6).
Owner:BEIJING SHIQIAO BIOPHAM

Tumor antigen based on products of the tumor suppressor gene WT1

A tumor antigen that comprises, as an active ingredient, a product of the Wilms' tumor suppressor gene WT1 or a peptide composed of 7-30 contiguous amino acids containing an anchor amino acid for binding to major histocompatibility complex (MHC) class I in said amino acid sequence, and a vaccine comprising said antigen.
Owner:INT INST OF CANCER IMMUNOLOGY INC

Novel fourth-generation infant formula and preparation method thereof

The invention provides a novel fourth-generation infant formula. The novel fourth-generation infant formula comprises the following ingredients: lactose, desalted whey powder, 1,3-dioleoyl 2-palmitoyl triglyceride, hydrolyzed whey protein, fructo-oligosaccharide, galactooligosaccharide, mineral substance premix compound, casein hydrolysate, whey protein concentrate, soyabean lecithin, vitamin premix, lactoferrin, L-tyrosine, nucleotide, L-tryptophan, L-methionine and the like. The infant formula is added with appropriate amount of 1,3-dioleoyl 2-palmitoyl triglyceride, appropriate amount of protein hydrolysate, monomer amino acid and the like, mineral contents such as phosphorus, sodium and the like in milk powder are reduced, therefore, the fat structure, the amino acid composition, the amino acid content and the osmotic pressure in the milk powder are close to those of the breast milk, the infant formula is balanced and comprehensive in nutrition and is appropriate in composition, all substances have synergistic effect, the bioavailability of protein and the fat is effectively improved, and the infant formula can promote digestive absorption and skeletal development of babies and can reduce the visceral organ burden.
Owner:AUSNUTRIA DAIRY CHINA

Industrial production method of hydrolyzed wheat protein for feeding

The invention discloses an industrial production method of hydrolyzed wheat protein for feeding, belonging to the technical field of feed additive production. In the method, through the method of synergy of multiple enzymes and combined treatment of multiple steps, the hydrolyzed wheat protein for feeding is prepared by taking wheat gluten meal and water with weight ratio of 1:10-1:2 and adding compound enzyme, ensuring the mass percent concentration of the compound enzyme in the solution is 0.2-1.4%, hydrolyzing the mixture for 1-13h under the conditions that the temperature is 30-70 DEG C and pH value is 5.0-10.0, then carrying out such processes as filtering, decoloring and drying, etc. Compared with the traditional methods, the method of the invention features mild hydrolysis conditions, sanitation and safety and maintains the original nutritive composition of amino acid free of loss; the hydrolysate is low in salt content, mellow in mouth feel and high in yield which is up to 98%. The tests that the hydrolyzed wheat protein is added in the feed for suckling pigs, chicks, calves, aquaculture and the like to be used show that the hydrolyzed wheat protein has the advantages and evident effects of improving daily feed intake, reducing diarrhea rate, enhancing immunity, slowing weanling stress, improving growth performance and the like.
Owner:郑州新威营养技术有限公司

Anti-(influenza a virus subtype h5 hemagglutinin) monoclonal antibody

InactiveUS20110065095A1Prevention of prevalenceFaster assayMicrobiological testing/measurementBiological material analysisHemagglutininEpitope
A method of immunoassay of H5 subtype influenza A virus by which the virus can be accurately assayed even in cases where a certain level of mutation has occurred in the H5 subtype influenza A virus, and a kit therefor, and a novel anti-H5 subtype influenza A virus monoclonal antibody which can be used for the immunoassay are disclosed. The antibody or an antigen-binding fragment thereof of the present invention undergoes antigen-antibody reaction with hemagglutinin of H5 subtype influenza A virus, and the corresponding epitope of the antibody or an antigen-binding fragment thereof is located in a region other than the receptor subdomain (excluding C-terminal region thereof consisting of 11 amino acids), which antibody or an antigen-binding fragment thereof does not have neutralizing activity against the influenza A virus.
Owner:FUJIREBIO CO LTD +1

New type marine microorganism of lysozyme and bacillus 5-12 of producing lysozyme in high yield

The invention relates to a bacillus S-12 of high yield ocean microorganism lysozyme which separated from sea mud of The East China Sea.It is conserved at the type cultivating matter protect center of HuHan China, with CCTCC NO:M204089.The ratio that this S-12 and Bacillus bacterial homology is between 98% and 99%.It is a new fungus ilk with a filiation.The bacteriolysin molecular weight produced by this fungus is 39KD,consisted of 354 aminophenolls. It can be widely used in cosmetic, medicament, disinfector and breeding fields.
Owner:YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI

Protection of exendin-4 peptides through conjugation

A method for protecting a peptide from peptidase activity in vivo, the peptide being composed of between 2 and 50 amino acids and having a C-terminus and an N-terminus and a C-terminus amino acid and an N-terminus amino acid is described. In the first step of the method, the peptide is modified by attaching a react group to the C-terminus amino acid, to the N-terminus amino acid, or to an amino acid located between the N-terminus and the C-terminus, such that the modified peptide is capable of forming a covalent bond in vivo with a reactive functionality on a blood component. In the next step, a covalent bond is formed between the reactive group and a reactive functionality on a blood component to form a peptide-blood component conjugate, thereby protecting said peptide from peptidase activity. The final step of the method involves the analyzing of the stability of the peptide-blood component conjugate to assess the protection of the peptide from peptidase activity.
Owner:CONJUCHEM +1

Synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome

InactiveUS6624140B1Prevent septic shockAntibacterial agentsBiocideAlpha helixSaxitoxin
A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable alpha-helix and has the following structure comprising at least 12 amino acidsA=an amino acid selected from the basic amino acids Lys,Arg or HisB=an amino acid selected from the aromatic amino acids Phe, Trp or TyrC=an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, Val or Ala, andsaid peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-m of the repetitive sequence motifs (A2-B2-C1-A3) have the retro orientation and the remaining repetitive motifs (A2-B2-C1-A3) have the orientation as presented in the formula and wherein,R1-R2- and R3 are a number of amino acids, and whereinm=1-10, preferably 2-8, more preferably 2-5 andn=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or diagnosis related to i.a. parasite infection topical and systemic tumors and septic shock.
Owner:ACADEMISCH ZIEKENHUIS BIJ DE UNIV VAN AMSTERDAM ACADEMISCH MEDISCH CENT +1

Composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening

The invention relates to composite children toothpaste suitable for use in the morning and in the evening and children toothpaste suitable for use in the evening. The composite children toothpaste suitable for use in the morning and in the evening comprises children toothpaste suitable for use in the morning and the children toothpaste suitable used in the evening. The children toothpaste suitable for use in the morning comprises a moisture retention agent, a thickening agent, a soft abrasive, xylitol, a calcium-containing compound, composite vitamins, a mild surfactant, essence and deionized water. The children toothpaste suitable for use in the evening comprises a moisture retention agent, a thickening agent, a soft abrasive, oligosaccharide, an amino acid composition, composite vitamins, a mild surfactant, essence and deionized water. According to the influence produced by a change of a children oral cavity environment in the morning and in the evening on teeth, the composite children toothpaste suitable for use in the morning and in the evening can maintain an oral cavity microecology balance, can balance an oral cavity acid-base value and can prevent carious teeth and strong teeth.
Owner:广州舒客实业有限公司

Green mud crab antibacterial peptide Sphistin and application thereof

The invention discloses a green mud crab antibacterial peptide Sphistin and application thereof, relates to the technical field of genetic engineering of crustaceans, and provides the green mud crab antibacterial peptide Sphistin and the application thereof. A molecular formula of the green mud crab antibacterial peptide Sphistin is C170H293N61O46S1 and molecular weight of the green mud crab antibacterial peptide Sphistin is 3,959.61 Dalton. The antibacterial peptide Sphistin consists of 38 amino acids, is derived from a part of sequences at end N of green mud crab histone 2A protein and is apolypeptide with an antibacterial function. By adopting the conventional solid-phase chemical synthesis method, the green mud crab antibacterial peptide Sphistin with purity of over 95 percent can beobtained. The green mud crab antibacterial peptide Sphistin has an obvious antibacterial effect on various gram negative bacteria and gram positive bacteria, has a broad antibacterial spectrum and high sterilization rate, shows extremely high medical value and is excellently applied to preparing antibacterial agents.
Owner:XIAMEN UNIV

Composition and method for modifying the fatty acid composition of cell membranes of organs and tissues

InactiveUS7560486B2Rapid and efficient uptake/enrichmentRestore balanceBiocideMetabolism disorderTG - TriglycerideCell membrane
The present invention relates to a composition and method for rapidly modifying the fatty acid composition of cell membranes of organs and tissues, in particular to increase the amount of omega-3 fatty acids of cell membranes of organs and tissues by parenterally administering to the human or animal body a supply of fatty acids in the form of an isotonic lipid emulsion comprising fatty acid triglycerides.
Owner:CARPENTIER YVON +1

High efficiency blooming-promoting foliage-spraying microbial fertilizer

InactiveCN1370408ALow costFacilitate differentiation workBiocideAnimal repellantsAnimal sciencePhosphate
The high efficiency blooming-promoting foliage spraying microbial fertilizer includes a mixture of amino acid of seven cytokinins, red sugar, potassium chlorate, mineral salt of nucleotide, ethylene,abscisic acid and potassium dihydrogen phosphate as main agent and a synergist comprising farm washing powder for foliage penetration, absorption and adhesion. It can promote blossom bud differentiation of fruit trees, especially longan, litchi, Shatian shaddock, and other substropical fruit trees. It has the features of low cost, high safety, high efficiency and no pollution.
Owner:谢明阳

Method for planting good-quality and high-yield Chinese herbal medicine

The invention discloses a method for planting a good-quality and high-yield Chinese herbal medicine. The method comprises the steps as follows: a nutrient is applied during growing of the Chinese herbal medicine; the nutrient mainly comprises components in percentage by weight as follows: 10%-80% of nucleotide salt and deoxynucleotide salt and 20%-90% of sugar or / and amino acid. During growing, the time for applying the nutrient and the concentration of the nutrient are as follows: the nutrient is sprayed at the bloom stage and the full bloom stage respectively; and the concentration is 100 ppm-260 ppm. The method has the advantages as follows: the nutrient is non-poisonous, harmless and residue-free to the Chinese herbal medicine, and avoids adverse side effects the production and the yield are increased, the efficiency is improved, the resistance is enhanced, and the effect for improving the quality is good; and the method is simple, the cost is low, and large-scale production and popularization are facilitated.
Owner:安徽冯了性中药材饮片有限公司
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