261 results about "Amino acid composition" patented technology

The invention provides copper-loaded duck-origin lactobacillus plantarum with high antibacterial peptide yield and application of the copper-loaded duck-origin lactobacillus plantarum. The preservation number of the provided copper-loaded duck-origin lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) NO.32835. The domesticated and bred duck-origin lactobacillus plantarum with high antibacterial peptide yield can tolerate high-concentration copper ions, the domesticated and bred lactobacillus plantarum can stably grow, and the contents of antibacterial peptide, extracellular protein, lipase, amylase, lactic acid, acetic acid and the like in the domesticated and bred lactobacillus plantarum strain are increased; and the amino acid composition is changed. The strain can convert inorganic copper into organic copper, the utilization rate of copper is increased, and growth and development of organisms are promoted. Moreover, small peptides and extracellular proteins in metabiotics generated after fermentation have the effect of effectively inhibiting harmful bacteria such as riemerella anatipestifer, escherichia coli, salmonella and staphylococcus of poultry, and are beneficial to eliminating intestinal inflammatory factors, maintaining intestinal health and improving the feed utilization rate.

The invention provides an amino acid frosted cleaning composition as well as a preparation method and application thereof. The amino acid frosted cleaning composition comprises a surfactant, an amino acid composition, a thickening agent, a humectant, an antioxidant, a pH regulator and water, the surfactant is a combination of cocoyl glycinate, cocamidopropyl hydroxy sulfobetaine, sodium cocoyl methyl taurine taurate, sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium and glycolipid. According to the invention, a mild surfactant system with amino acid as a main component is adopted, so that the shampoo has rich and fine foam, quick foaming performance and easy washing performance, and the skin feeling is smooth and soft after washing. In addition, the system contains suspended crystal frosted particles formed by self-assembly of the amino acid composition, the appearance is novel, the better efficacy performance is achieved, and meanwhile the cleaning effect and the use comfort are improved.

The invention relates to the field of food, and provides a soybean protein product and a preparation method thereof.The method comprises the steps that soybean and water are subjected to pulp grinding and centrifugal treatment, and residue-removed soybean milk and soybean residues are obtained; performing cold precipitation and centrifugal treatment on the residue-removed soybean milk to obtain a cold precipitation precipitate and a cold precipitation supernatant; carrying out ultrafiltration treatment on the cold precipitation supernatant, and collecting retentate; respectively drying the cold precipitation precipitate and the intercepted substance to obtain a cold precipitation dried substance and an intercepted dried substance; and carrying out mixing treatment on the cold-precipitated dried substance and the intercepted dried substance to obtain the soybean protein product. The soybean protein product prepared by the method contains all amino acids essential to human bodies, the proportion of the amino acids is close to that of ideal amino acids, and the nutritional value is high. Moreover, the method is simple and convenient to operate, low in cost and suitable for large-scale production.

The design consists of a rectangular shape on the left side, excluding the dotted lines; in the center of the drawing, there is an arched window-shaped feature with a curved upper portion; floral patterns are arranged along the border of the arched window, and a cow's face is depicted at the bottom of the drawing; the nutrition facts and full amino acid in the drawing form no part of the claimed design.

The invention provides an amino acid water-soluble fertilizer as well as a preparation method and application thereof, and relates to the technical field of amino acid water-soluble fertilizers. The amino acid water-soluble fertilizer comprises compound amino acid, a microbial fermentation product, inorganic salt, a surfactant, a dispersing agent and a preservative, the microbial fermentation product is obtained by aerobic fermentation of radix puerariae and rhizoma atractylodis through a complex microbial inoculant; the compound amino acid is composed of animal protein hydrolyzed amino acid and vegetable protein hydrolyzed amino acid. According to the water-soluble fertilizer disclosed by the invention, through the synergistic interaction of the compound amino acid and the microbial fermentation product, multi-objective optimization of nutrition supply, stress resistance regulation and metabolism enhancement is realized, the yield and the quality of crops are remarkably improved, an efficient and environment-friendly solution for increasing the yield and improving the quality is provided for the crops, and the water-soluble fertilizer has a remarkable agricultural application value.

Semisolid supplement compositions are disclosed comprising at least one non-ester nitrate compound and at least one isolated amino acid compound. The at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound. The composition contains at least about 0.05625 mg nitrate ion (NO3−).

The invention discloses a method for impregnating coffee beans with fructose under the assistance of ultrasonic waves, and relates to the technical field of food processing, and the method is technically characterized by comprising the following steps: selecting Robursta coffee beans with the moisture content of 10-12%; mixing with a 5% fructose solution according to a solid-liquid ratio of 1: 4, treating for 5-20 minutes (preferably 5 minutes) under ultrasonic waves of 40 kHz and 120 W, and totally impregnating for 4 hours; performing forced air drying at 40 DEG C for 23h until the water content is 10- And baking at the temperature of 175 DEG C for 7-8 minutes. A honeycomb net structure is formed on the surface of the coffee beans through ultrasonic treatment, the total sugar content is remarkably increased to 54.65 mg / g, amino acid composition is affected, and bioactive substances such as polyphenol and flavone are increased. The score of the baked coffee beans is more than 72 (the score of the coffee beans is 74.92 after the coffee beans are subjected to ultrasonic treatment for 5 minutes) through an SCA cup test, and the coffee beans have caramel fragrance, nut fragrance and smoother mouth feel. The method is simple and convenient to operate, low in cost and capable of effectively improving the flavor quality of the Robursta coffee.

The invention relates to the technical field of biological medicines, and discloses a polypeptide for treating osteoarthritis by aiming at AHR (Aryl Hydrocarbon Receptor), the amino acid sequence of the polypeptide is GFQQSDVIHQSVYELISINHTEDRA, and the amino acid sequence of the polypeptide is GFQQSDVIHQSVYELISINHTEDRA, and the amino acid sequence of the polypeptide is GFQQSDVIHQSVYELISINHTEDRA. The polypeptide is prepared by a solid-phase polypeptide synthesis method; the solid-phase polypeptide synthesis method specifically comprises the following steps: synthesizing from a C end to an N end, connecting a carboxyl group of a first amino acid to insoluble resin, then adding other amino acids one by one to form a peptide chain, and carrying out protection and deprotection reactions of a side chain in each step. The polypeptide is composed of natural amino acids and has good biocompatibility and degradability, and experimental results show that no obvious toxic reaction occurs in the cell level and the animal level, so that the polypeptide has conditions for further development of pharmacokinetic research and preclinical tests, and a feasible basis is provided for conversion to clinical application.

The invention discloses an amino acid composition for treating alopecia and application of the amino acid composition in preparation of a medicine for treating alopecia, and belongs to the field of medicine configuration products, the amino acid composition is composed of a targeting core intervention component and an auxiliary strengthening synergistic component, the targeting core intervention component is prepared from 30-50 parts of arginine, 50-155 parts of lysine and 50-120 parts of glutamic acid, and the auxiliary strengthening synergistic component is prepared from an auxiliary strengthening synergistic component and an auxiliary strengthening synergistic component. 10 to 40 parts of cysteine and 20 to 60 parts of leucine; the auxiliary strengthening synergistic component is prepared from 15 to 45 parts of tyrosine, 15 to 40 parts of glycine, 10 to 40 parts of glutamine, 20 to 35 parts of serine, 5 to 25 parts of alanine, 2 to 20 parts of aspartic acid and 15 to 35 parts of phenylalanine; the composition can be used as an active ingredient to be prepared into different dosage forms such as a pigmentum, a spray, an ointment and a liniment, is applied to prevention of alopecia and promotion of hair growth, and has a remarkable treatment effect.

This invention discloses a soil improvement and fertilization fertilizer for rhizosphere micro-domains in saline-alkali land and its preparation method, belonging to the field of saline-alkali land management technology. The fertilizer consists of a microbial core, a slow-release fertilizer sub-outer layer, and a soil conditioner outer layer. The microbial core is composed of a compound microbial agent (composed of nitrogen-fixing bacteria, phosphate-solubilizing bacteria, and potassium-active bacteria), biochar, and a high-molecular organic membrane material. The slow-release fertilizer sub-outer layer is composed of chemical fertilizers, inhibitors (nitrification inhibitors and / or urease inhibitors), and amino acids. The soil conditioner outer layer is composed of a soil conditioner specifically for saline-alkali land improvement. The advantages of this invention are: (1) it first adjusts the soil pH and improves the soil structure, so that the microbial community can better adapt to the soil environment of saline-alkali land; (2) the biochar and the isolation membrane effectively protect the microbial activity, and release the microorganisms when the soil pH and base ions around the rhizosphere reach a low level, overcoming the saline-alkali barrier to microbial growth.

The invention relates to the technical field of flower flowering phase regulation and control, and discloses a regulator and a method for promoting secondary flowering of crape myrtle, the regulator comprises 50 parts by weight of benzylaminopurine, 4.6-5 parts by weight of compound sodium nitrophenolate and more than or equal to 100 parts by weight of an amino acid composition; or 18 parts by weight of benzylaminopurine, 18 parts by weight of gibberellin, 4.6-5 parts by weight of compound sodium nitrophenolate and more than or equal to 100 parts by weight of an amino acid composition. The regulator provided by the invention comprehensively acts on multiple aspects of cell division, dormancy breaking, hormone regulation, nutrition supply, stress resistance enhancement and the like to jointly promote secondary blooming of the crape myrtle, increase the blooming amount and prolong the blooming period, and by virtue of multiple aspects of effects of pruning, fertilization, insect killing, plant growth regulator regulation and the like, the yield of the crape myrtle is increased. Secondary blooming of the crape myrtle is promoted, the blooming rate, the blooming duration and the blooming amount of secondary blooming are increased, and the growth vigor of the crape myrtle in the next year is not affected.

The present invention relates to a composition for enhancing or protecting muscles, comprising a fermented salmon roe product. According to the present invention, if salmon roe is fermented, the amino acid composition of proteins changes, and the effects of promoting muscle synthesis, inhibiting muscle degradation and damage, and protecting muscles are greatly improved. Therefore, the fermented salmon roe product of the present invention can be applied to food to exhibit effects of enhancing and protecting muscles, and can also be used as a pharmaceutical composition for preventing or treating sarcopenia or amyotrophic diseases through the effects.

The objective of the present invention is to provide a peptide having ACE inhibitory activity and a composition thereof. [Solution] The present invention discloses a peptide with ACE inhibitory activity and a composition thereof. The peptide is composed of three amino acids and has the ability to inhibit ACE activity. Therefore, by administering an effective amount of the peptide disclosed in the present invention or a composition containing the peptide to an individual, the individual's blood pressure can be effectively adjusted to approach normal values, thereby achieving the effect of preventing and / or treating hypertension and its related diseases.

A solid supplement composition comprising at least one non-ester nitrate compound and at least one isolated amino acid compound, wherein the at least one isolated amino acid compound is citrulline, wherein the at least one isolated amino acid compound is a separate compound than the at least one non-ester nitrate compound, and wherein the solid supplement composition comprises an amount of nitrate ion (NO3—) that is at least 0.33125 mg.

The invention provides an allosteric nanogel adjuvant as well as a preparation method and application thereof, and belongs to the technical field of vaccines. The allosteric nanogel adjuvant comprises a self-assembly motif, a responsive site and an immunomodulatory peptide fragment, and the self-assembly motif is composed of 2-5 amino acids; the allosteric nanogel adjuvant has a structure as shown in a formula I, and is named as NTP5 for short; the allosteric nanogel adjuvant is self-assembled into nanoparticles, the nanoparticles are allosteric into a nanofiber structure through responsive broken bonds, nanogel is further formed, and the key problems of a traditional vaccine in the aspects of antigen delivery and immune activation are effectively solved. The nanogel adjuvant can efficiently load various antigens to form a stable nano vaccine, activate an immune microenvironment and provide more means and thoughts for vaccine development.

Disclosed herein are boronated amino acid compositions comprising tyrosine derivatives TC220 and TC221 and improved methods of making TC220 and TC221. Thus, the TC220 and / or TC221 can be expanded to commercial scale and administered to patients as neutron trapping agents, and methods of treating cancer, immune disorders, and other diseases by utilizing a neutron capture therapy pattern are provided.

The invention discloses a method for detecting polypeptide sequence difference and post-translational modification thereof based on a nanopore system, the nanopore system is constructed in the method, and the nanopore system comprises an alpha-hemolysin nanopore and octa-amino modified gamma-cyclodextrin embedded in the nanopore; the amino acid sequence of the alpha-hemolysin nanopore comprises mutation sites M113R and T145R, and the alpha-hemolysin nanopore is characterized in that the alpha-hemolysin nanopore According to the detection method, polypeptide with negative charges enters a nanopore under the driving of external voltage, an ion current blocking signal is recorded, and the polypeptide sequence difference and post-translational modification are analyzed according to blocking amplitude, duration, noise characteristics and event frequency. The method can detect a peptide chain with the length of 2-10 amino acid residues, can distinguish the post-translational modification state in homopolypeptide composed of 4-10 amino acids and polypeptide by single amino acid resolution, and can be used for protein enzyme digestion product analysis, oligopeptide drug detection and rapid polypeptide identification under the condition of no mass spectrum.

The invention discloses a compound vitamin amino acid premix as well as a preparation method and application thereof, and belongs to the technical field of feed additives. An embedding system is formed by the chitosan, the polyethylene glycol and the glyceryl ricinoleate, and the tea tree oil and the perilla oil are compounded to serve as an antioxidant, so that the stability of vitamins can be remarkably improved. Besides, hydroxyapatite is added into the starch, modification treatment is performed through succinic anhydride and polyvinylpyrrolidone, the component compatibility is good, o-vanillin is introduced, the fragrance of o-vanillin has a food calling effect, the palatability is improved, the components of the functional additive are optimized, and the remarkable immune enhancement and growth promotion effects can be achieved; the cellular immunity and humoral immunity functions of the body are enhanced, and the granulating formability is effectively promoted by combining with the components of the carrier with good compatibility. On the whole, through interaction of the vitamin composition, the amino acid composition, the functional additive and the carrier, the immunity and growth performance of animals are jointly improved from multiple aspects.

The present application relates to oxidized squalene cyclase, recombinant vector, recombinant engineering bacteria and application thereof, and preparation method of parkol. The oxidized squalene cyclase comprises: a polypeptide consisting of the amino acid sequence shown as SEQ ID No. 1; or a polypeptide consisting of the amino acid sequence shown as SEQ ID No. 1 with one or more amino acids being deleted, substituted or added; or a polypeptide having at least 80% homology with the polypeptide consisting of the amino acid sequence shown as SEQ ID No. 1. The above-mentioned oxidized squalene cyclase can catalyze 2, 3 oxidized squalene to produce parkol, and the enzyme can be expressed according to the coding sequence of the cyclase, and then the substrate is catalyzed to improve the yield of parkol.

The invention provides a method for analyzing polypeptide or protein in a to-be-detected sample, which comprises the following steps of: separating by reversed-phase high-performance liquid chromatography, measuring the content of free amino acid before and after hydrolysis of the to-be-detected sample by a detector, determining the amino acid composition of the polypeptide or protein according to the difference value, and indirectly reflecting the content of polypeptide or protein impurities. The analysis method disclosed by the invention has the characteristics of simplicity in operation, strong specificity, high accuracy, good reproducibility and the like, and is successfully applied to analysis research and quality control of residual polypeptide impurities in raw material medicines of levodopa and lacosamide.

The invention discloses a solid beer-flavor effervescent tablet and a preparation method thereof. The solid beer-flavor effervescent tablet comprises an acid source, an alkali source, a beer-flavor matrix, a sweetening agent, a filling agent, a nutrition enhancer and a processing aid, wherein the acid source comprises anhydrous citric acid, and the alkali source comprises sodium bicarbonate; the beer flavor matrix comprises malt flour, a humulus lupulus extract and a flavor enhancer, and the flavor enhancer comprises flavor essence and concentrated guava juice; the nutrition enhancer comprises vitamin B, mineral salt and an amino acid composition. According to the invention, rich and pure beer flavor and rich, fine and lasting foam can be generated after the beer is disintegrated in water, and the beer has good portability and long shelf life, and has a nutrition supplementing function.

The invention discloses a preparation method of an ingredient containing waste milk and the ingredient. The ingredient is prepared from the following raw materials in parts by weight: 900-1100 parts of waste milk, 8-12 parts of a compound microbial preparation and 25-45 parts of a culture medium auxiliary material, the compound microbial preparation is prepared from bacillus subtilis, bacillus licheniformis, lysozyme and protease, wherein the mass ratio of the bacillus subtilis is 32 to 38 percent, the mass ratio of the bacillus licheniformis is 32 to 38 percent, the mass ratio of the lysozyme is 12 to 18 percent, and the mass ratio of the protease is 12 to 18 percent; the culture medium auxiliary material consists of protein powder, brown sugar powder and amino acid, and the mass ratio of the protein powder to the brown sugar powder to the amino acid is 1: 20: 5. According to the invention, the waste milk is used as a main raw material, so that the resource utilization of wastes is realized, the environmental pollution is reduced, and the production cost of the feed is reduced.

The invention belongs to the crossing field of bioinformatics and computational biology, and relates to a method for identifying succinylation sites based on a language model driven by entity knowledge. According to the method, firstly, amino acid composition (AAC), One-Hot coding and residue distance-based features (DR) are fused to construct a multi-dimensional composite feature set, then an entity knowledge enhanced LUKE model and a robustness optimized RoBERTa model are respectively coupled with a bidirectional long-short term memory network (BiLSTM), and context dynamic modeling is realized by extracting deep features of a pre-training model. And a final prediction model is obtained through model fine tuning and integration strategy fusion. Finally, according to the method, t-SNE feature visualization and SHAP interpretability are combined to analyze and verify biological, physical and chemical reasonability of model decision, and accurate recognition of protein succinylation sites is achieved.

The invention relates to the field of keratin extraction methods. More particularly, the invention relates to a method for extracting keratin, in particular human hair keratin, without chemical products. The method comprises three thermal hydrolysis steps. The keratin obtained is of high quality, the amino acid composition of same being close to that of native keratin, and can be used in applications with a high added value such as cosmetics or medical devices. The biomimicry between the keratin extracted from hair using this extraction method and natural keratin is more than 90%.

The present invention relates to synthetic designs or chimeric proteins for pseudotyping baculovirus (Autographa californica nuclear polyhedrosis virus) with the rabies virus glycoprotein G (gG) on its surface (Bac::gG-FL), which can be used in anti-rabies vaccine formulations. The chimeric protein is designed from a gene cassette containing gene fragments of the ectodomain of the G glycoprotein of the Pasteur strain rabies virus, a linker of 7 amino acids (GGGGSGG), as well as transmembrane (TM) and cytoplasmic (CT) regions of the gp64 baculovirus protein, with the arrangement of the sequences in the designed gene cassette being shown in figure 1.

The AgDoa gene and application thereof in reducing the pesticide resistance of cotton aphids belong to the technical field of biological genetic engineering, the DNA sequence of the AgDoa gene is shown as SEQ ID No:1, and the AgDoa gene is composed of 1782 nucleotides; the amino acid sequence of the protein coded by the AgDoa gene is shown as SEQ ID No:2, and the protein is composed of 593 amino acids; the AgDoa gene can be used as a target to develop a new pesticide; the tolerance of the cotton aphids to the pesticide is reduced by knocking down the AgDoa gene, and the AgDoa gene can be applied in the resistance management and development of new pesticides.

This invention discloses a plant-based amino acid composition for improving sleep and relieving anxiety, its preparation method, and its applications, relating to the fields of functional foods and nutritional health technology. The composition includes jujube seed extract, lily extract, poria cocos extract, polygonum multiflorum extract, arborvitae seed extract, clove extract, γ-aminobutyric acid (GABA), theanine, magnesium glycine, and L-glycine. This invention utilizes GABA to reduce nerve excitability; theanine to help improve relaxation; jujube seed extract to enhance sleep stability; glycine to lower core body temperature; and magnesium glycine to stabilize the nervous system. Its improving effects are manifested in: improving NREM sleep quality, enhancing sleep continuity, promoting deep sleep recovery, and reducing drowsiness the following day. It achieves the technical effects of shortening sleep onset time, increasing the proportion of deep sleep, reducing the number of nighttime awakenings, and improving the feeling of sleep recovery.

To provide new and improved methods of treating cancer, immune disorders, and other diseases utilizing borylated amino acids and neutron capture therapy (NCT).SOLUTION: Disclosed herein are borylated amino acid ("BAA") compositions and methods of making BAAs. Accordingly, BAAs can be administered to patients as neutron capture agents and can provide methods of treating cancer, immune disorders, and other diseases by utilizing neutron capture therapy modalities. The invention described herein relates to the field of boron neutron capture therapy (BNCT). In particular, the present invention relates to borylated amino acid ("BAA") or ("BAAs") compositions that can be used as a vehicle for neutron capture therapy in humans. The invention further relates to the treatment of cancer and other immune disorders and diseases.SELECTED DRAWING: None

The invention discloses a radioactive diagnosis medicine for targeting OPN as well as a preparation method and application of the radioactive diagnosis medicine. The radioactive diagnosis medicine comprises linear polypeptide and radionuclide, wherein the linear polypeptide is composed of 20 L-type amino acids and one D-type amino acid, and the radionuclide marks the linear polypeptide through a bifunctional chelating agent; the sequence of the linear polypeptide is as shown in SEQ ID NO. 1. In vivo, radionuclides in the medicine are concentrated to an atherosclerotic vulnerable plaque part through the targeting effect of the amino acid linear polypeptide, and imaging diagnosis is carried out on the atherosclerotic vulnerable plaque by utilizing a positron emission computed tomography technology of nuclear medicine.

The present invention relates to a peptide of 12 to 30 amino acids, said peptide comprising the sequence SEQ ID NO: 1 represented by:(SEQ ID NO: 1)V-X1-X2-R-X3-E-W-X4-X5-X6-Y-W,wherein each of X1, X2, X3, X4, X5, and X6 independently corresponds to any amino acid, andwherein said peptide binds to the EGF receptor variant III (EGFRvIII), as well as products incorporating such peptide and uses thereof.