59 results about "Liniment" patented technology

The invention relates to equipment for preparing clobetasol propionate liniment and a preparation method of the clobetasol propionate liniment. The equipment comprises a material mixing mechanism, a barrel, a stirring shaft rotationally arranged on the barrel, stirring blades for stirring substances, a partition plate for separating the interior of the barrel, a crystallization rod for cooling materials and a drying mechanism for drying the substances. Wherein the stirring blades are fixedly arranged around the stirring shaft, and the stirring blades at the bottom are arranged around the stirring shaft in a swinging manner; the partition plate is movably arranged in the barrel around the stirring shaft; the crystallization rod is movably arranged at the bottom of the barrel; the drying mechanism communicates with the bottom of the barrel; the drying mechanism is communicated with the mixing mechanism; the partition plate is arranged between the fixed first ring frame and the rotary second ring frame; the partition plate is connected with the first ring frame and the second ring frame. The second ring frame rotates to drive the partition plate to open or separate the cylinder. The preparation method solves the problem that the preparation efficiency of clobetasol propionate is affected due to more preparation equipment caused by complex process steps in the clobetasol propionate liniment preparation process in the existing scheme.

The invention relates to a phytoextraction external liniment for promoting black hair growth and a preparation method thereof. According to the liniment, a polygonum multiflorum extract, a cacumen biotae supercritical extract and molecular embedded black sesamin in a specific proportion are taken as cores and are matched with an azone-menthol transdermal enhancer and a propylene glycol-olive oil carrier, and black hair growth is synergistically promoted through triple mechanisms of activating tyrosinase, inhibiting melanocyte apoptosis and promoting cell migration. The preparation method adopts a gradient temperature extraction combined molecular embedding technology, the polygonum multiflorum is subjected to stepped purification at 40-60 DEG C-80 DEG C to retain thermosensitive active ingredients, the black sesamin is embedded by beta-cyclodextrin to improve the stability, and finally, the nano microemulsion is formed through two-stage homogeneous emulsification. The liniment can efficiently permeate into the deep layer of hair follicles, the efficiency of turning white hair into black is remarkably improved, and skin irritation is avoided.

The present invention discloses the use of schisandra extract in a preparation for preventing and treating hair loss or promoting hair regeneration, belonging to the field of hair loss treatment. The schisandra of the present invention includes a combination of one or more of schisandra A and schisandra B. The present invention found that both schisandra A and schisandra B can significantly promote the proliferation of hair follicle cells; schisandra B can significantly promote hair regeneration after androgenic alopecia, and at the same time, the effect of promoting hair regeneration is related to the concentration of schisandra B. The present invention relates to a drug for treating hair loss, which includes schisandra A and schisandra B and a drug combination, as well as an optional pharmaceutically acceptable carrier. The drug can be prepared into different dosage forms such as external use solution, lotion, liniment, ointment, plaster, paste, patch, etc. for convenient use.

The invention discloses a hair-growing liniment and a preparation method thereof, and belongs to the technical field of pharmacy. The liniment comprises the following components in percentage by weight: 1-10% of minoxidil microspheres, 5-20% of a film-forming agent, 0.5-5% of a polypeptide compound, 5-30% of a liquid auxiliary material and the balance of deionized water. Wherein the minoxidil microspheres are of a three-layer structure composed of minoxidil in the inner layer, nano enzyme (cerium dioxide) in the middle layer and lactic acid-glycolic acid ester copolymer or chitosan in the outer layer, and controlled release and targeted delivery are achieved; the polypeptide compound is a compound of oldenlandia diffusa polypeptide and a copper curcumin derivative, and has the effect of synergistically repairing a hair follicle microenvironment. Tests prove that the liniment can remarkably prolong the release time of minoxidil, increase the retention volume of minoxidil in hair follicle parts and reduce absorption of the whole body, shows a hair growth promoting effect superior to that of a traditional preparation and a single-layer microsphere preparation in an animal model, and has good stability and use comfort.

The application belongs to the field of pharmaceutical preparations and relates to a chlorpheniramine maleate liniment, which contains chlorpheniramine maleate 1 part, a cosolvent 100-140 parts, a stabilizer 12-25 parts and a binder 5-15 parts. The solubility and stability of chlorpheniramine maleate are improved, and the content of related substances in the preparation is reduced by optimizing the types and proportions of the cosolvent and the stabilizer. The full dissolution of chlorpheniramine maleate and excipients is facilitated by optimizing the preparation process, in particular the dissolution step of chlorpheniramine maleate and the stabilizer. The preparation process is simple, suitable for industrial production and convenient for market promotion.

The invention discloses clobetasol propionate liniment and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The clobetasol propionate liniment provided by the invention consists of clobetasol propionate and dipotassium glycyrrhizinate which serve as effective components, absolute ethyl alcohol serving as a cosolvent and a novel eutectic solvent aqueous solution. The eutectic solvent aqueous solution is prepared by heating a citric acid aqueous solution and a tartaric acid aqueous solution under specific conditions. The invention also provides a method for preparing the clobetasol propionate liniment. A eutectic solvent formed by citric acid and tartaric acid is used as a main solvent, so that the use amount of absolute ethyl alcohol is reduced, and the use irritation is reduced. According to the liniment, the solubility and stability of clobetasol propionate which is extremely difficult to dissolve in water in a liniment system are improved, meanwhile, the formula system is mild, skin irritation caused by ethyl alcohol is reduced, and the liniment has good safety and application prospects.

The utility model relates to the technical field of collateral activating liniment application devices, in particular to a collateral activating liniment administration device which solves the technical problem that in the prior art, a device which is applied to the collateral activating liniment and is used for conveniently and rapidly applying the collateral activating liniment in place is lacked, and specifically comprises a collateral activating liniment administration bottle body. An inner cavity is formed in the collateral activating liniment administration bottle body and used for being filled with collateral activating liniment liquid. An external thread connecting part and an internal thread connecting part are arranged at an opening of the collateral activating liniment administration bottle body; the inner suction part is further provided with a liquid suction pipe and a liquid storage sponge, and the liquid suction pipe can extend into the collateral activating liniment administration bottle body; the administration part can be connected to the external thread connecting part, the administration part is provided with a smearing end, and the smearing end can obtain collateral activating liniment liquid through the liquid storage sponge. The collateral activating liniment liquid can be applied to the skin through the applying end, and the collateral activating liniment liquid applying device is stable, safe, free of liquid scattering, high in adaptability and suitable for being used in families.

The invention relates to an amorolfen liniment, and belongs to the field of external pharmaceutical preparations. By adding a specific type of penetration enhancer into the amorolfen liniment, the amorolfen liniment can realize higher retention volume of the medicine in nails and has higher nail penetration capacity, namely, the penetration speed and degree of the medicine on the nails are obviously increased, the defects in the prior art are overcome, and the amorolfen liniment is suitable for clinical application. And a better choice is provided for clinical treatment of nail fungal infection.

The utility model discloses a liniment stirring device with a heating structure, which comprises a stirring barrel and an outer barrel, and relates to the technical field of liniment stirring. On one hand, the processing area is arranged in the interlayer of the stirring barrel and the outer barrel, the coil is sleeved on the outer side of the outer barrel, the water supply barrel and the water storage barrel are sleeved on the outer side of the coil, the water supply barrel and the water storage barrel are both communicated with the processing area through water pipes, and the vacuumizer is arranged on one side of the outer barrel and communicated with the processing area through an air pipe. On the other hand, the stirrer is arranged in the stirring barrel, so that the air pressure in the processing area can be controlled through the vacuumizer in the stirring process of the liniment in the stirring barrel, and the interior of the processing area is in a negative pressure state, and in the state, redundant air in the processing area can be pumped out to ensure that the liniment in the stirring barrel is not polluted by air; and the boiling point of water input into the processing area by the water supply barrel can be reduced, the stability of the processing temperature in the stirring barrel is maintained, and the stirring barrel is protected from being influenced by the overheating temperature of the coil.

The application discloses a compound morinda officinalis color-increasing liniment for treating vitiligo and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine preparations, wherein the liniment is prepared from morinda officinalis, spilanthes acmella, giant knotweed, caesalpinia sappan, psoralea corylifolia, radix angelicae dahuricae and rhizoma smilacis glabrae as raw medicinal materials. The preparation method comprises the following steps: dynamic reflux extraction, percolation extraction, macroporous adsorption resin purification and preparation molding. Through the classification extraction and purification process, the photosensitive active ingredients are retained, and the photo-toxic impurities are effectively removed, so that the photo-toxicity is completely negative. The pharmacodynamic test shows that the liniment has a significant curative effect on vitiligo. The safety test shows that the liniment has no skin irritation and no allergenicity, and has excellent light safety. The quality research shows that the quality of the liniment is stable and controllable. The liniment has definite curative effect, high safety and stable quality, and has a good clinical application prospect.

The invention relates to the technical field of pharmaceutical analysis, in particular to an HPLC (High Performance Liquid Chromatography) fingerprint spectrum construction method and application of a twelve-ingredient numbness pain liniment. The construction method comprises the following steps: preparing a test solution; preparing a reference substance solution; and HPLC determination. The HPLC fingerprint spectrum construction method of the twelve-ingredient numbness pain liniment is provided for the first time, and the method has the advantages of being high in precision, good in reproducibility, high in stability and good in durability. Meanwhile, the method disclosed by the invention can be used for detecting the contents of three components including polydatin, stilbene glucoside and emodin in the twelve-ingredient numbness pain liniment at one time. Technical support is provided for comprehensively improving the product quality standard of the twelve-ingredient arthralgia pain liniment and optimizing the preparation process, identifying true and false and carrying out follow-up material basic research of the twelve-ingredient arthralgia pain liniment.

The invention discloses all-traditional Chinese medicine traumatic injury medicinal liquor and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of rubus suavissimus, 35-45 parts of ventilago leiocarpa benth, 25-35 parts of fructus schisandrae chinensis, 12-18 parts of asarum sieboldii, 35-45 parts of semiliquidambar cathayensis, 35-45 parts of entada phaseoloides, 17-23 parts of kadsura pepper stem, 25-35 parts of lindera glauca, 35-45 parts of lysimachia christinae hance, 25-35 parts of angelica sinensis, 25-35 parts of berchemia lineate, 35-45 parts of oxalis, 35-45 parts of radix achyranthis bidentatae, 17-23 parts of artabotrys hexapetalus, 25-35 parts of sappanwood The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 to 45 parts of radix notoginseng, 25 to 35 parts of bodhi, 25 to 35 parts of radix aristolochiae fordianae, 17 to 23 parts of crane knee, 30 to 40 parts of caulis sargentodoxae, 20 to 30 parts of cyathea spinulosa wall, 35 to 45 parts of tinospora sinensis merr, 25 to 35 parts of ardisia punctata, 35 to 45 parts of knottedflower knotweed root, 20 to 30 parts of flos carthami, 35 to 45 parts of cynanchum otophyllum, 25 to 35 parts of schizophragma serratum, 25 to 35 parts of radix cynanchi paniculati and 35 to 45 parts of champion bauhinia root. The traditional Chinese medicine is reasonable and unique in compatibility, remarkable in curative effect and comprehensive in efficacy and gives consideration to exterior and interior.

The invention relates to a compound turpentine liniment as well as a preparation method and application of the compound turpentine liniment. Comprising the following preparation raw materials in percentage by mass: 8 to 12 percent of turpentine, 45 to 55 percent of glycerol, 12 to 18 percent of cyperus esculentus extract, 5 to 10 percent of soft soap, 0.5 to 1.5 percent of camphor, 0.1 to 1 percent of glucosamine, 0.5 to 2 percent of chondroitin sulfate, 0.1 to 1 percent of dimethyl sulfone, 0.5 to 2.5 percent of oil-soluble azone, 0.1 to 1 percent of lauramide propyl amine oxide and 12 to 20 percent of purified water. The cyperus esculentus extract prepared by the preparation method disclosed by the invention is compounded with the turpentine for use, a certain synergistic effect exists between the cyperus esculentus extract and the turpentine, the effect of reducing inflammatory factors in serum of the compound turpentine liniment can be improved, and the high-temperature-resistant stability is good; the compound turpentine liniment has an obvious better effect on reducing inflammatory factors in serum, so that a synergistic effect possibly exists between cellulase and mannase, and the compound turpentine liniment has a better curative effect on arthritis.

A method of treating gout in a patient is provided. The method comprises topically applying to a gout-affected area of the patient an external nano liniment comprising a cream phase and nanoparticles dispersed in the cream phase. The nanoparticles have a coating structure comprising a water phase, an oil phase and a water phase in sequence from inside to outside. Active ingredients for treating gout are embedded or dispersed in the water phase and / or the oil phase of the nanoparticles, and a particle size distribution of the nanoparticles is in a range of 1-200 nm. The topical application reduces uric acid levels in blood, dissolves gout crystals, and relieves symptoms including joint redness, swelling, hotness, and pain while avoiding systemic side effects associated with oral administration of gout medications.

The application provides a use of a combination of metoclopramide and latanoprost for preparing an anticoagulant drug, and belongs to the technical field of biological medicines. It is accidentally found that the anticoagulant effect of patients with deep vein thrombosis combined with high intraocular pressure is improved after long-term continuous oral administration of metoclopramide. Thanks to this beneficial discovery, the application realizes good anticoagulant effect by applying the latanoprost liniment in a topical manner on the basis of oral administration of metoclopramide. The application is convenient to administer, has definite and sustained curative effect, and is safe and reliable. The application expands the optional range of anticoagulant drugs, and realizes better curative effect at the same time, and has outstanding technical advantages and wide popularization prospect.

The invention discloses a traditional Chinese medicine liniment for treating lumbocrural pain and hyperostosis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine liniment is prepared from notopterygium root, radix angelicae pubescentis, angelica sinensis, fructus lycii, flos carthami, clove and radix saposhnikoviae according to a specific weight part ratio through soaking in wine and extracting, and auxiliary materials such as glycerol can also be added according to requirements. The traditional Chinese medicine composition is scientific in formula, integrates functions of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and tonifying liver and kidney, and is high in permeability, quick in effect, good in stability and small in side effect. The preparation method adopts a percolation method for extraction, so that effective components can be reserved to the greatest extent, and stable quality of liquid medicine is ensured. The traditional Chinese medicine can be used for effectively treating arthralgia such as lumbocrural pain, hyperostosis, lumbar disc herniation, rheumatic arthritis and the like, and has good clinical application value.

1. Name of the product in this design: Packaging Bottle (Liv-Clobetasol Propionate Liniment). 2. Purpose of this design: As a packaging bottle. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A pharmaceutical formulation for treating alopecia, a preparation method therefor and the use thereof are provided. Specifically, a formulation or composition for treating alopecia contains the following active components on the basis of the mass percentage (w / w) or mass / volume percentage (w / v): (a) 5% of minoxidil; and (b) 0.07-0.095% of finasteride. The formulation or the composition is a foaming agent or a liniment. When the formulation is a foaming agent, the total mass in the mass percentage does not contain the mass of a propellant.

The invention belongs to the technical field of pharmacy, and particularly relates to minoxidil liniment and a preparation method thereof. According to the minoxidil liniment disclosed by the invention, the nano-liposome prepared from the lichen extract-phospholipid complex is used for wrapping minoxidil, the common allergic dermatitis phenomenon in the using process of the minoxidil liniment is avoided by utilizing a synergistic drug loading mechanism of the lichen extract and the phospholipid complex and through anti-inflammatory and anti-oxidation effects, and meanwhile, the drug structure is protected; the action time of the minoxidil liniment is prolonged; the gel substance formed by the polyvinyl alcohol-sodium carboxymethyl cellulose composite coating liquid reduces the surface exposure of minoxidil, avoids the precipitation of minoxidil crystals, and ensures the delivery and absorption efficiency of minoxidil drugs.

The invention discloses a calcipotriol liniment, which is prepared from the following components in percentage by weight: 0.001 to 0.005 percent of calcipotriol, 0.04 to 0.06 percent of pH (Potential of Hydrogen) regulator, 0.8 to 1.5 percent of phospholipid, 12 to 20 percent of glycerol and the balance of triglyceride. In the liniment disclosed by the invention, the active ingredient calcipotriol is uniformly dispersed in the stable dispersion medium to obtain a uniform solution, and the stability of the calcipotriol and related impurities is relatively good. When the liniment is prepared, the materials do not need to be heated, on one hand, the selected materials are in a normal liquid state or have good solubility in a dispersion medium, and on the other hand, the similar intermiscibility principle is utilized; therefore, calcipotriol degradation loss caused by heating in the preparation process is avoided.

1.The name of the design product: packaging box (three yellow active liniment). 2.The use of the design product: for packaging box. 3.The design points of the design product: in shape, pattern, color and combination thereof. 4.The picture or photo best indicating the design points: perspective view 1. 5.The design claimed contains color.

The invention relates to the field of biomedical materials, and particularly provides a preparation method of bioactive hydrogel for clinically retaining and slowly releasing medicine liniment.The preparation method comprises the following steps that S1, aminophenylboronic acid is dissolved in water to prepare an aminophenylboronic acid aqueous solution, a glucan derivative is added, after heating and stirring reaction, a product is collected, washed and dried, and the hydrogel is obtained; a hydrogel precursor is obtained; s2, polyphenol substances and polysaccharide substances are added into 0.5 wt%-20 wt% of an aqueous solution of the hydrogel precursor, after stirring reaction is conducted, 0.02 wt%-8 wt% of a hydrazide aqueous solution is added into the aqueous solution, ultrasonic treatment is conducted, standing is conducted, and the bioactive hydrogel can be obtained. By optimizing the variety and dosage of the components, the hydrogel can be attached to the skin, retention of the traditional Chinese medicine liniment at the focus of the skin is helped, and the action time of the liniment medicine is prolonged to 12-24 h.

The invention discloses an externally-applied liniment containing saussurea involucrata and perilla oil for herpes zoster and a preparation method of the externally-applied liniment, and relates to the technical field of externally-applied traditional Chinese medicine preparations, the liniment is prepared from the following components in parts by weight: 30-40 parts of fresh stem and leaf extract of saussurea involucrata, 15-20 parts of perilla oil, 0.5-1 part of forsythin, 0.1-0.3 part of vitamin B12, 0.3-0.5 part of vitamin E and 40-50 parts of mountain spring water; according to the preparation method disclosed by the invention, the extract of the fresh stems and leaves of the herba ecliptae and the perilla oil are adopted as cores and compounded with the forsythin, the vitamin B12 and the vitamin E to form a synergistic effect system, and the optimized processes of ultrasonic extraction, reflux concentration, low-temperature squeezing, centrifugal purification and ultraviolet sterilization are combined, so that the active ingredients of all the components are fully released; the active ingredients of the saussurea involucrata and the forsythin synergistically inhibit virus replication and relieve inflammation, the perilla oil and the vitamin B12 jointly repair damaged nerves, the vitamin E protects skin barriers and improves the stability of the preparation, and the raw materials of the preparation are all natural ingredients or natural active factors, so that the safety is high, and the risk of skin irritation is avoided.

This invention relates to a modified long-acting sustained-release coating agent for topical liquid formulations, its preparation method, and its application, belonging to the field of pharmaceutical preparations. The modified long-acting sustained-release coating agent for topical liquid formulations comprises a carrier and a topical liquid formulation in a mass ratio of 1:1 to 3:2. The carrier includes PVA, glycerin, liquid paraffin, β-hydroxyethyl urea, glyceryl stearate, PEG stearate, and purified water. The topical liquid formulation includes one or more of the following: tincture, liniment, solution, lotion, ointment, oil, and rinse. This invention's long-acting sustained-release coating agent is a universal coating agent, safe to use, non-irritating, and has no incompatibility with topical liquid formulations. It facilitates film formation, has a short film-forming time, and produces a flexible film that is not easily detached.

A preparation method of an external nano liniment for gout is provided. The preparation method comprises the following steps: dissolving active ingredients into a water phase and / or an oil phase; adding a part of the water phase to a stirred oil phase to obtain hydrated oil phase nanoparticles; adding the hydrated oil phase nanoparticles to a part of the stirred water phase to obtain nanoparticles; and adding a cream phase to the stirred nanoparticles to obtain the nano liniment. The nanoparticles are of a coating structure having a water phase, an oil phase and a water phase in sequence from inside to outside, active ingredients used for treating gout are embedded or dispersed in the water phase and / or the oil phase of the nanoparticles, and a size distribution of the nanoparticles is in a range of 1-200 nm.

The present application relates to the technical field of minoxidil, in particular to a preparation method of minoxidil liniment. The preparation method comprises the following steps: preparing a raw material solution containing minoxidil by using glacial acetic acid solution, adding water ophrydis volatile oil, polyethylene glycol 400 and propylene glycol, and adding soybean lecithin to prepare the external use nanometer minoxidil liniment. The minoxidil liniment forms micro-nanoparticles and can be stored for a long time. In the prior art, ethanol is used as an auxiliary material, and the minoxidil liniment provided by the present application has no skin irritation in single administration and multiple administrations, and the skin irritation is reduced.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a novel application of tofacitinib or a pharmaceutical composition containing the tofacitinib, and the tofacitinib exists in a medicine in the form of tofacitinib or pharmaceutically acceptable salt of the tofacitinib. The medicine can be prepared into an external preparation, including an external solution and an external semisolid, the external solution includes a solution, a foaming agent, a spray, a tincture and a liniment, and the external semisolid includes an ointment, a cream, a gel, a patch and an emplastrum; the external preparation can be a tofacitinib foaming agent and comprises the following components: tofacitinib or pharmaceutically acceptable salt thereof, a solvent, a humectant, a foam stabilizer, a surfactant, a pH regulator, an antioxidant and water, and the antioxidant comprises L-arginine and butylated hydroxytoluene.

1. Name of the product in this design: Packaging Box (Minoxidil Liniment). 2. Purpose of this design: For packaging products. 3. The key design elements of this product are the combination of shape, pattern, and color. 4. The picture or photo that best illustrates the key design points: Design 1 front view. 5. The design for which protection is sought includes color. 6. Design 1 is designated as the basic design.

The application belongs to the technical field of pharmacy, and particularly relates to a minoxidil liniment and a preparation method thereof. The application wraps minoxidil by using a lichen extract-phospholipid complex to prepare nano-liposomes, utilizes the synergistic drug loading mechanism of the lichen extract and the phospholipid complex, avoids the common allergic dermatitis phenomenon in the use process of the minoxidil liniment through anti-inflammatory and antioxidant effects, protects the drug structure, and prolongs the action time of the minoxidil liniment; the gel-like substance formed by using a polyvinyl alcohol-carboxymethylcellulose sodium complex coating solution reduces the surface exposure of minoxidil, avoids the precipitation of minoxidil crystals, and guarantees the delivery and absorption efficiency of minoxidil drugs.

1. The name of the design product: medicine packaging box (minoxidil liniment). 2. The use of the design product: the design product is used for medicine packaging box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: perspective view.