34 results about "Liniment" patented technology

The invention relates to equipment for preparing clobetasol propionate liniment and a preparation method of the clobetasol propionate liniment. The equipment comprises a material mixing mechanism, a barrel, a stirring shaft rotationally arranged on the barrel, stirring blades for stirring substances, a partition plate for separating the interior of the barrel, a crystallization rod for cooling materials and a drying mechanism for drying the substances. Wherein the stirring blades are fixedly arranged around the stirring shaft, and the stirring blades at the bottom are arranged around the stirring shaft in a swinging manner; the partition plate is movably arranged in the barrel around the stirring shaft; the crystallization rod is movably arranged at the bottom of the barrel; the drying mechanism communicates with the bottom of the barrel; the drying mechanism is communicated with the mixing mechanism; the partition plate is arranged between the fixed first ring frame and the rotary second ring frame; the partition plate is connected with the first ring frame and the second ring frame. The second ring frame rotates to drive the partition plate to open or separate the cylinder. The preparation method solves the problem that the preparation efficiency of clobetasol propionate is affected due to more preparation equipment caused by complex process steps in the clobetasol propionate liniment preparation process in the existing scheme.

The invention discloses a hair-growing liniment and a preparation method thereof, and belongs to the technical field of pharmacy. The liniment comprises the following components in percentage by weight: 1-10% of minoxidil microspheres, 5-20% of a film-forming agent, 0.5-5% of a polypeptide compound, 5-30% of a liquid auxiliary material and the balance of deionized water. Wherein the minoxidil microspheres are of a three-layer structure composed of minoxidil in the inner layer, nano enzyme (cerium dioxide) in the middle layer and lactic acid-glycolic acid ester copolymer or chitosan in the outer layer, and controlled release and targeted delivery are achieved; the polypeptide compound is a compound of oldenlandia diffusa polypeptide and a copper curcumin derivative, and has the effect of synergistically repairing a hair follicle microenvironment. Tests prove that the liniment can remarkably prolong the release time of minoxidil, increase the retention volume of minoxidil in hair follicle parts and reduce absorption of the whole body, shows a hair growth promoting effect superior to that of a traditional preparation and a single-layer microsphere preparation in an animal model, and has good stability and use comfort.

The utility model relates to the technical field of collateral activating liniment application devices, in particular to a collateral activating liniment administration device which solves the technical problem that in the prior art, a device which is applied to the collateral activating liniment and is used for conveniently and rapidly applying the collateral activating liniment in place is lacked, and specifically comprises a collateral activating liniment administration bottle body. An inner cavity is formed in the collateral activating liniment administration bottle body and used for being filled with collateral activating liniment liquid. An external thread connecting part and an internal thread connecting part are arranged at an opening of the collateral activating liniment administration bottle body; the inner suction part is further provided with a liquid suction pipe and a liquid storage sponge, and the liquid suction pipe can extend into the collateral activating liniment administration bottle body; the administration part can be connected to the external thread connecting part, the administration part is provided with a smearing end, and the smearing end can obtain collateral activating liniment liquid through the liquid storage sponge. The collateral activating liniment liquid can be applied to the skin through the applying end, and the collateral activating liniment liquid applying device is stable, safe, free of liquid scattering, high in adaptability and suitable for being used in families.

The application discloses a compound morinda officinalis color-increasing liniment for treating vitiligo and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicine preparations, wherein the liniment is prepared from morinda officinalis, spilanthes acmella, giant knotweed, caesalpinia sappan, psoralea corylifolia, radix angelicae dahuricae and rhizoma smilacis glabrae as raw medicinal materials. The preparation method comprises the following steps: dynamic reflux extraction, percolation extraction, macroporous adsorption resin purification and preparation molding. Through the classification extraction and purification process, the photosensitive active ingredients are retained, and the photo-toxic impurities are effectively removed, so that the photo-toxicity is completely negative. The pharmacodynamic test shows that the liniment has a significant curative effect on vitiligo. The safety test shows that the liniment has no skin irritation and no allergenicity, and has excellent light safety. The quality research shows that the quality of the liniment is stable and controllable. The liniment has definite curative effect, high safety and stable quality, and has a good clinical application prospect.

The invention relates to the technical field of pharmaceutical analysis, in particular to an HPLC (High Performance Liquid Chromatography) fingerprint spectrum construction method and application of a twelve-ingredient numbness pain liniment. The construction method comprises the following steps: preparing a test solution; preparing a reference substance solution; and HPLC determination. The HPLC fingerprint spectrum construction method of the twelve-ingredient numbness pain liniment is provided for the first time, and the method has the advantages of being high in precision, good in reproducibility, high in stability and good in durability. Meanwhile, the method disclosed by the invention can be used for detecting the contents of three components including polydatin, stilbene glucoside and emodin in the twelve-ingredient numbness pain liniment at one time. Technical support is provided for comprehensively improving the product quality standard of the twelve-ingredient arthralgia pain liniment and optimizing the preparation process, identifying true and false and carrying out follow-up material basic research of the twelve-ingredient arthralgia pain liniment.

The invention discloses all-traditional Chinese medicine traumatic injury medicinal liquor and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25-35 parts of rubus suavissimus, 35-45 parts of ventilago leiocarpa benth, 25-35 parts of fructus schisandrae chinensis, 12-18 parts of asarum sieboldii, 35-45 parts of semiliquidambar cathayensis, 35-45 parts of entada phaseoloides, 17-23 parts of kadsura pepper stem, 25-35 parts of lindera glauca, 35-45 parts of lysimachia christinae hance, 25-35 parts of angelica sinensis, 25-35 parts of berchemia lineate, 35-45 parts of oxalis, 35-45 parts of radix achyranthis bidentatae, 17-23 parts of artabotrys hexapetalus, 25-35 parts of sappanwood The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 35 to 45 parts of radix notoginseng, 25 to 35 parts of bodhi, 25 to 35 parts of radix aristolochiae fordianae, 17 to 23 parts of crane knee, 30 to 40 parts of caulis sargentodoxae, 20 to 30 parts of cyathea spinulosa wall, 35 to 45 parts of tinospora sinensis merr, 25 to 35 parts of ardisia punctata, 35 to 45 parts of knottedflower knotweed root, 20 to 30 parts of flos carthami, 35 to 45 parts of cynanchum otophyllum, 25 to 35 parts of schizophragma serratum, 25 to 35 parts of radix cynanchi paniculati and 35 to 45 parts of champion bauhinia root. The traditional Chinese medicine is reasonable and unique in compatibility, remarkable in curative effect and comprehensive in efficacy and gives consideration to exterior and interior.

A method of treating gout in a patient is provided. The method comprises topically applying to a gout-affected area of the patient an external nano liniment comprising a cream phase and nanoparticles dispersed in the cream phase. The nanoparticles have a coating structure comprising a water phase, an oil phase and a water phase in sequence from inside to outside. Active ingredients for treating gout are embedded or dispersed in the water phase and / or the oil phase of the nanoparticles, and a particle size distribution of the nanoparticles is in a range of 1-200 nm. The topical application reduces uric acid levels in blood, dissolves gout crystals, and relieves symptoms including joint redness, swelling, hotness, and pain while avoiding systemic side effects associated with oral administration of gout medications.

The application provides a use of a combination of metoclopramide and latanoprost for preparing an anticoagulant drug, and belongs to the technical field of biological medicines. It is accidentally found that the anticoagulant effect of patients with deep vein thrombosis combined with high intraocular pressure is improved after long-term continuous oral administration of metoclopramide. Thanks to this beneficial discovery, the application realizes good anticoagulant effect by applying the latanoprost liniment in a topical manner on the basis of oral administration of metoclopramide. The application is convenient to administer, has definite and sustained curative effect, and is safe and reliable. The application expands the optional range of anticoagulant drugs, and realizes better curative effect at the same time, and has outstanding technical advantages and wide popularization prospect.

The invention discloses a traditional Chinese medicine liniment for treating lumbocrural pain and hyperostosis and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine liniment is prepared from notopterygium root, radix angelicae pubescentis, angelica sinensis, fructus lycii, flos carthami, clove and radix saposhnikoviae according to a specific weight part ratio through soaking in wine and extracting, and auxiliary materials such as glycerol can also be added according to requirements. The traditional Chinese medicine composition is scientific in formula, integrates functions of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and tonifying liver and kidney, and is high in permeability, quick in effect, good in stability and small in side effect. The preparation method adopts a percolation method for extraction, so that effective components can be reserved to the greatest extent, and stable quality of liquid medicine is ensured. The traditional Chinese medicine can be used for effectively treating arthralgia such as lumbocrural pain, hyperostosis, lumbar disc herniation, rheumatic arthritis and the like, and has good clinical application value.

1. Name of the product in this design: Packaging Bottle (Liv-Clobetasol Propionate Liniment). 2. Purpose of this design: As a packaging bottle. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

A pharmaceutical formulation for treating alopecia, a preparation method therefor and the use thereof are provided. Specifically, a formulation or composition for treating alopecia contains the following active components on the basis of the mass percentage (w / w) or mass / volume percentage (w / v): (a) 5% of minoxidil; and (b) 0.07-0.095% of finasteride. The formulation or the composition is a foaming agent or a liniment. When the formulation is a foaming agent, the total mass in the mass percentage does not contain the mass of a propellant.

The invention discloses a calcipotriol liniment, which is prepared from the following components in percentage by weight: 0.001 to 0.005 percent of calcipotriol, 0.04 to 0.06 percent of pH (Potential of Hydrogen) regulator, 0.8 to 1.5 percent of phospholipid, 12 to 20 percent of glycerol and the balance of triglyceride. In the liniment disclosed by the invention, the active ingredient calcipotriol is uniformly dispersed in the stable dispersion medium to obtain a uniform solution, and the stability of the calcipotriol and related impurities is relatively good. When the liniment is prepared, the materials do not need to be heated, on one hand, the selected materials are in a normal liquid state or have good solubility in a dispersion medium, and on the other hand, the similar intermiscibility principle is utilized; therefore, calcipotriol degradation loss caused by heating in the preparation process is avoided.

1.The name of the design product: packaging box (three yellow active liniment). 2.The use of the design product: for packaging box. 3.The design points of the design product: in shape, pattern, color and combination thereof. 4.The picture or photo best indicating the design points: perspective view 1. 5.The design claimed contains color.

The invention relates to the field of biomedical materials, and particularly provides a preparation method of bioactive hydrogel for clinically retaining and slowly releasing medicine liniment.The preparation method comprises the following steps that S1, aminophenylboronic acid is dissolved in water to prepare an aminophenylboronic acid aqueous solution, a glucan derivative is added, after heating and stirring reaction, a product is collected, washed and dried, and the hydrogel is obtained; a hydrogel precursor is obtained; s2, polyphenol substances and polysaccharide substances are added into 0.5 wt%-20 wt% of an aqueous solution of the hydrogel precursor, after stirring reaction is conducted, 0.02 wt%-8 wt% of a hydrazide aqueous solution is added into the aqueous solution, ultrasonic treatment is conducted, standing is conducted, and the bioactive hydrogel can be obtained. By optimizing the variety and dosage of the components, the hydrogel can be attached to the skin, retention of the traditional Chinese medicine liniment at the focus of the skin is helped, and the action time of the liniment medicine is prolonged to 12-24 h.

The invention discloses an externally-applied liniment containing saussurea involucrata and perilla oil for herpes zoster and a preparation method of the externally-applied liniment, and relates to the technical field of externally-applied traditional Chinese medicine preparations, the liniment is prepared from the following components in parts by weight: 30-40 parts of fresh stem and leaf extract of saussurea involucrata, 15-20 parts of perilla oil, 0.5-1 part of forsythin, 0.1-0.3 part of vitamin B12, 0.3-0.5 part of vitamin E and 40-50 parts of mountain spring water; according to the preparation method disclosed by the invention, the extract of the fresh stems and leaves of the herba ecliptae and the perilla oil are adopted as cores and compounded with the forsythin, the vitamin B12 and the vitamin E to form a synergistic effect system, and the optimized processes of ultrasonic extraction, reflux concentration, low-temperature squeezing, centrifugal purification and ultraviolet sterilization are combined, so that the active ingredients of all the components are fully released; the active ingredients of the saussurea involucrata and the forsythin synergistically inhibit virus replication and relieve inflammation, the perilla oil and the vitamin B12 jointly repair damaged nerves, the vitamin E protects skin barriers and improves the stability of the preparation, and the raw materials of the preparation are all natural ingredients or natural active factors, so that the safety is high, and the risk of skin irritation is avoided.

This invention relates to a modified long-acting sustained-release coating agent for topical liquid formulations, its preparation method, and its application, belonging to the field of pharmaceutical preparations. The modified long-acting sustained-release coating agent for topical liquid formulations comprises a carrier and a topical liquid formulation in a mass ratio of 1:1 to 3:2. The carrier includes PVA, glycerin, liquid paraffin, β-hydroxyethyl urea, glyceryl stearate, PEG stearate, and purified water. The topical liquid formulation includes one or more of the following: tincture, liniment, solution, lotion, ointment, oil, and rinse. This invention's long-acting sustained-release coating agent is a universal coating agent, safe to use, non-irritating, and has no incompatibility with topical liquid formulations. It facilitates film formation, has a short film-forming time, and produces a flexible film that is not easily detached.

A preparation method of an external nano liniment for gout is provided. The preparation method comprises the following steps: dissolving active ingredients into a water phase and / or an oil phase; adding a part of the water phase to a stirred oil phase to obtain hydrated oil phase nanoparticles; adding the hydrated oil phase nanoparticles to a part of the stirred water phase to obtain nanoparticles; and adding a cream phase to the stirred nanoparticles to obtain the nano liniment. The nanoparticles are of a coating structure having a water phase, an oil phase and a water phase in sequence from inside to outside, active ingredients used for treating gout are embedded or dispersed in the water phase and / or the oil phase of the nanoparticles, and a size distribution of the nanoparticles is in a range of 1-200 nm.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an indometacin liniment for external use and a preparation process thereof, the indometacin liniment is prepared by compounding indometacin, a composite solubilizer, a composite stabilizer, a penetration enhancer, a humectant, a pH regulator and a solvent; wherein the composite solubilizer is a compound system of ethanol, N-sodium methyl taurate, lauroyl lysine and propylene glycol, the composite stabilizer is a compound system of ethylene diamine tetraacetic acid, acetylcysteine and dithiothreitol, the penetration enhancer is peppermint oil, the humectant is glycerol, the pH regulator is triethanolamine / citric acid, and the solvent is purified water. Through the specific compounding design of the components and the precise control of the preparation process, the obvious improvement of the water solubility of the indometacin and the effective guarantee of the content stability of the preparation are synchronously realized.

The invention relates to the technical field of eyelash growth assisting liniments, and particularly discloses a bemaprost liniment and a preparation method thereof. The invention relates to a bemeprost liniment, which is prepared from the following raw materials in percentage by mass: 0.01 to 0.03 percent of bemeprost, 0.3 to 0.5 percent of minoxidil, 3 to 5 percent of oil phase, 0.3 to 0.5 percent of vitamin H, 0.05 to 0.15 percent of sodium hyaluronate, 8 to 10 percent of ethanol, 0.11 to 0.13 percent of penetration enhancer, 0.3 to 0.4 percent of growth substance, 0.083 to 0.097 percent of sodium chloride, 0.03 to 0.06 percent of sodium alginate and the balance of water. According to the liniment disclosed by the invention, the bemeprost, the minoxidil and the vitamin H are matched, and the penetration enhancer and the growth substance are combined, so that the curative effect on eyelash growth is improved.

1. The name of the design product: packaging box of imidazole nitrate liniment. 2. The use of the design product: for packaging imidazole nitrate liniment. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: front view.

This invention relates to a topical tincture for treating psoriasis and its preparation method. The herbal formula comprises: 16-36 parts by weight of Psoralea corylifolia, 2-6 parts by weight of Cinnamomum cassia, 18-41 parts by weight of Zaocys dhumnades, 9-20 parts by weight of Bombyx mori excrement, and 9-20 parts by weight of Angelica dahurica. The above herbal formula is prepared as a tincture using 75% alcohol. Based on traditional empirical formulas and combined with the clinical symptoms of psoriasis in Traditional Chinese Medicine, this invention selects suitable herbs with photosensitive components. The formula exhibits good drug compatibility and interactions, and can be used independently or in combination with natural sunlight or ultraviolet radiation, greatly improving efficacy.

1. Name of the product in this design: Outer Packaging Box (Liv Clobetasol Propionate Liniment). 2. Purpose of this design: As an outer packaging box. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a preparation method of a traditional Chinese medicine external liniment for treating viral warts, and relates to the technical field of traditional Chinese medicine external preparations, and the preparation method sequentially comprises the following steps: raw material pretreatment: respectively taking seven medicinal materials including horsetail, prepared cantharides, cyperus rotundus, prepared arisaema consanguineum schott, raw rhubarb, angelica dahurica and wild agastache rugosus, washing, and drying at 50-65 DEG C until the moisture content is less than or equal to 10% to obtain dried medicinal materials; the formula aims at the pathogenesis of heat toxin accumulation and qi and blood stasis of virus warts, the compatibility of monarch, minister, assistant and guide is rigorous, the core medicines such as the processed cantharides and the raw rhubarb have the effects of directly corroding warts and inhibiting viruses, and the alkalization auxiliary materials are combined, so that the medicine can more effectively act on wart tissues with abnormal hyperplasia, and the effect of treating the warts is achieved. The process route of low-temperature drying, co-crushing, alkalization and long-time cold soaking is adopted, the damage of high-temperature decoction to effective components (especially cantharidin and the like) is avoided, the efficient and sufficient extraction of the active components is realized through long-time soaking and alkalization environment, and the stability of the efficacy of the preparation is ensured.

1. The name of the design product: medicine packaging box (minoxidil liniment). 2. The use of the design product: the design product is used for medicine packaging box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

This utility model belongs to the field of container technology and discloses a cooling oil container, including a container shell, which is a cylindrical structure with an open end and a hollow interior. It also includes a spiral groove on the inner surface of the container shell, a positioning component rotatably disposed at the opening of the container shell, a lifting tray disposed inside the container shell, a sliding head disposed between the lifting tray and the container shell, and a container cap detachably fastened to the positioning component. The positioning component extends into the interior of the container shell, the lifting tray is slidably connected to the container shell with its surface perpendicular to the sliding direction, and the sliding head is fixedly connected to the lifting tray and slides along the spiral groove. This utility model, through the cooperation of the spiral groove and the sliding head, drives the cooling oil to rise and pass through the positioning component to the outside for use when the lower container shell rotates. Simultaneously, rotating in the opposite direction allows the cooling oil to be stored inside the lower container shell, achieving convenient access to the cooling oil without the need for the laborious opening of traditional metal boxes.

The invention discloses a plant essential oil liniment for treating wind-cold-dampness arthralgia type osteoarthralgia and a preparation method of the plant essential oil liniment. The liniment takes cassia twig, notopterygium root, radix angelicae pubescentis, ginger, frankincense, myrrh, clove and other plant essential oil as active ingredients, takes grape seed oil and camellia seed oil as carrier substrates, and is added with azone as a penetration enhancer. Based on the theory of expelling wind, removing cold, removing dampness and dredging collaterals in traditional Chinese medicine, all the components have a synergistic effect through scientific proportioning and a special preparation process, and the transdermal absorption rate and bioavailability of the medicine are remarkably improved. The product has the advantages of quick response, exact curative effect, safety and convenience in use and the like, and is suitable for treating wind-cold-dampness arthralgia syndromes such as rheumatic arthritis, osteoarthritis and the like.

This utility model discloses a preparation device for external liniment, comprising a mixing tank, a filtering tank, a sterilizing tank, and a collecting tank connected in sequence. The mixing tank includes a tank body connected to a feeding pipe and a water inlet pipe assembly. The mixing tank contains a spraying structure, a sieving structure, and a stirring structure. The mixing tank is connected to the filtering tank via a fourth water pipe, and the filtering tank is connected to the sterilizing tank via a fifth water pipe. The sterilizing tank contains a filter membrane assembly and is connected to the collecting tank via a sixth water pipe. This utility model, by setting up the mixing tank, filtering tank, sterilizing tank, and collecting tank, can complete the entire preparation of the liniment.

This invention relates to a twelve-ingredient Bi Tong liniment for dispelling wind and dampness, promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain, and its uses. On one hand, this invention relates to a twelve-ingredient Bi Tong liniment, which is made from the following twelve medicinal herbs in the following weight ratios per 1000ml: 50-70g of *Smilax glabra*, 50-70g of *Asarum heterotropoides*, 25-35g of *Caulis Lysimachiae*, 10-20g of *Herba Clematis*, 8-12g of *Radix et Rhizoma Asarum*, 8-12g of *Radix Zanthoxyli*, 8-12g of *Radix Aconitum*, 20-30g of *Radix et Rhizoma Scutellariae*, 40-60g of *Radix Polygoni Cuscutae*, 15-25g of *Radix Sparganii*, 15-25g of *Rhizoma Curcumae*, and 15-25g of *Radix Curcumae*. In Miao medicine, this twelve-ingredient Bi Tong liniment has the function of lifting the shin and strengthening the legs; in traditional Chinese medicine, it has the functions of dispelling wind and dampness, promoting blood circulation, removing blood stasis, reducing swelling, and relieving pain. Clinically, it is often used for cold-dampness Bi syndrome, sprains, and muscle strains. The present invention's twelve-ingredient Bi Tong liniment has the excellent properties described in the specification, such as excellent biological effects.

1. The name of the design product: packaging box (menthol musk thymol liniment). 2. The use of the design product: for packaging menthol musk thymol liniment. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: front view.

The invention relates to a traditional Chinese medicine liniment for relieving swelling and pain and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine liniment is prepared from the following components in parts by weight: 40-60 parts of rheum officinale, 45-55 parts of radix angelicae, 50-55 parts of turmeric, 40-55 parts of golden cypress, 15-25 parts of rhizoma arisaematis, 15-20 parts of pericarpium citri reticulatae, 15-30 parts of rhizoma atractylodis, 20-25 parts of mangnolia officinalis, 15-25 parts of liquorice and 80-120 parts of radices trichosanthis. The traditional Chinese medicine liniment has the effects of clearing away heat and toxic materials, dispersing blood stasis, relieving swelling and pain and the like. The traditional Chinese medicine composition is widely used for eczema, acne, psoriasis, erysipelas, paronychia, soft tissue injury, acute cellulitis, acute suppurative lymphadenitis, perianal abscess, phlebitis, external humeral epicondylitis, gonarthromeningitis, swelling after fracture, burn and the like clinically.