The invention discloses sesame oil with a whitening effect. The sesame oil is prepared from the following raw materials in parts by weight: 1100 to 1200 parts of white sesame seed, 60 to 70 parts of coix seed, 10 to 15 parts of sweet-scented osmanthus, 5 to 10 parts of dried small shrimps, 5 to 8 parts of peony seed kernel, 10 to 15 parts of almond, 20 to 25 parts of white radish, 15 to 20 parts of pear, 20 to 30 parts of lemon, 30 to 40 parts of wax gourd, 2 to 3 parts of bighead atractylodes rhizome, 4 to 5 parts of radix paeoniae alba, 4 to 5 parts of white poria, 5 to 8 parts of milk, and proper amount of edible alcohol and water. According to the sesame oil with the whitening effect, the white sesame seed is used as the main raw material; coix seed has the effects of invigorating spleen to remove dampness, clearing away heat and eliminating pus, and whitening and beautifying; the added bighead atractylodes rhizome, radix paeoniae alba and white poria are traditional combination drugs capable of moistening the skin and whitening and have good effects on tonifying Qi and nourishing blood, whitening and moisturizing the skin; sesamin in the prepared sesame oil is rich in content and has an obvious flavor, and thus the nutritional value of the sesame oil is increased.