81 results about "Enteritis" patented technology

The invention provides a cobalt monatomic nano-enzyme system modified by phospholipid polyethylene glycol carboxyl. The cobalt monatomic nano-enzyme system comprises a cobalt monatomic nano-enzyme composite core and phospholipid polyethylene glycol carboxyl compounded on the surface of cobalt monatomic nano-enzyme, the cobalt monatomic nano-enzyme composite core comprises a cobalt monatomic nano-enzyme and ginsenoside loaded on the cobalt monatomic nano-enzyme. The invention also provides a bifidobacterium synergetic cobalt monatomic nano-enzyme system which is formed by combining cobalt monatomic nano-enzyme with ginsenoside Rb1 and further delivering the cobalt monatomic nano-enzyme and ginsenoside Rb1 through bifidobacterium bifidum for targeted therapy of enteritis. The combination of Co SA and Rb1 can enhance the anti-inflammatory efficacy by adjusting a key immune signal pathway, and bifidobacterium bifidum can ensure targeted delivery of microbiota and promote intestinal barrier repair. The synergistic three-component strategy integrating monatomic nano-enzyme antioxidation, natural drug immunoregulation and probiotic targeting is provided, and a promising treatment platform is provided for accurate intervention of IBD.

The invention provides a strain of high-temperature-resistant and inflammation-relieving Witzia ciliaris and an application thereof, the high-temperature-resistant and inflammation-relieving Witzia ciliaris is Witzia ciliaris CN985 and is preserved in the China Center for Type Culture Collection (CCTCC), the preservation date is April 7, 2024, and the preservation number is CCTCC NO: M 2024641. The invention further provides a preparation method of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain. The invention provides a brand new strain of Witzia ciliaris CN985, which is resistant to high temperature, has better acid resistance and bile resistance, and has no hemolysis risk when being applied to a human body. The Witzia coagulans CN985 has excellent antibacterial performance, and especially can significantly inhibit streptococcus pyogenes, salmonella enteritidis and / or group B streptococcus; besides, experimental results show that the Witzia ciliaris CN985 can relieve enteritis, improve the immunity of the organism and relieve pharyngitis, and especially when the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 are combined for use, the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 have a synergistic interaction effect, so that the relieving effect on enteritis can be remarkably improved.

The invention provides a decapterus maruadsi deepwater net cage culture method, and belongs to the technical field of decapterus maruadsi culture. According to the method, the submersible net cage is adopted, the decapterus maruadsi is located in the optimal growth water layer at the temperature of 20-25 DEG C all the year round according to rising and falling of seasons (surface water temperature), a guide pipe is adopted for fixed-point feed feeding, and the feed coefficient is reduced to 1.25 or below. According to the method, a water temperature-feeding amount-allicin-probiotics coupling model is established, the enteritis incidence rate in the high-temperature period is controlled within 2%, and annual continuous growth of decapterus maruadsi in deep and far sea is achieved.

The invention discloses a traditional Chinese medicine navel pill for treating constipation, diarrhea and chronic enteritis and a preparation method of the traditional Chinese medicine navel pill, and belongs to the technical field of traditional Chinese medicine. The preparation method comprises the following steps: weighing the raw materials, mixing, crushing and sieving to obtain mixed medicine powder, adding honey into the mixed medicine powder, stirring and kneading until the mixture is sticky, and preparing pills. The navel pill is applied to the navel, two-way conditioning of constipation and diarrhea is achieved through the synergistic effect of traditional Chinese medicine, chronic enteritis can be treated in a targeted mode, intestinal mucosa is effectively repaired, the intestinal inflammation state is improved, the navel pill has the advantages of being safe and convenient to apply, high in bioavailability, mild and free of side effects, stimulation of oral medicine to gastrointestinal tracts is avoided, and the curative effect is good. The food is suitable for digestion function conditioning of different people.

The present application provides a kind of complex probiotic paste, which combines Enterococcus faecalis, Saccharomyces cerevisiae and vitamin B 12 Producing lactic acid bacteria of canine source, adds prebiotics, flavoring substances and auxiliary substances such as paste matrix preparation.In the paste, the viable count of Enterococcus faecalis, Saccharomyces cerevisiae and lactic acid bacteria is 1-2:1-2:1-8;Paste matrix includes fructooligosaccharide 0.5-3%, psyllium husk powder 0.1-2%, goat milk powder 2-8%, chicken liver powder 1-5%, potassium sorbate 0.5-2%, xanthan gum 1-4%, and the balance is water.The above-mentioned complex probiotic paste can be stably stored for 56 days at 4 DEG C and normal temperature dry place, has good storage stability, good safety, and can adjust intestinal flora and increase the content of intestinal lactic acid bacteria.The above-mentioned complex probiotic paste has good palatability and oral tolerance for pets such as dogs and cats, and has good therapeutic effect on DSS-induced chronic enteritis diarrhea and vitamin B 12 Deficiency.

The present invention relates to the use of an animal feed additive composition for controlling the growth of undesirable microorganisms, said composition comprising glycerides, vegetable oils, tannins and / or saponins, the glycerol ester is selected from the group consisting of glycerol monopropionate, glycerol dipropionate and glycerol tripropionate, glycerol monobutyrate, glycerol dibutyrate and glycerol tributyrate, glycerol monovalerate, glycerol divalerate and glycerol trivalerate, and mixtures thereof. The invention also relates to the use of the animal feed additive composition for promoting intestinal growth, alleviating or alleviating effects from necrotizing enteritis, modulating intestinal flora and / or as an additive to drinking water.

The invention relates to the technical field of functional food preparation, in particular to a composition capable of improving colitis and a preparation method thereof, and the composition comprises glutamine, a composite plant extract, a zinc source and soluble dietary fibers. Wherein the compound plant extract comprises hericium erinaceus extract, ginseng extract and astragalus extract; the zinc source is zinc glycinate, zinc gluconate and the like; the soluble dietary fiber is fructo-oligosaccharide, inulin, galactomannan oligosaccharide and the like. The preparation method comprises the following steps: directly carrying out dry mixing or carrying out fluidized bed granulation on glutamine to obtain particles A, mixing the composite plant extract and the dietary fibers with ethanol, carrying out spray drying to obtain particles B, and carrying out three-dimensional mixing on the particles B and the zinc source. The composition can maintain the homeostasis of intestinal epithelial cells, reduce oxidative stress and inflammatory response, promote mucosal repair and effectively improve ulcerative colitis, Crohn's disease and chemoradiotherapy-related intestinal mucositis through multi-target action.

The invention provides an application of N4BP1 in preparation of an anti-enteritis drug, relates to the technical field of biomedicine, and particularly provides an application of N4BP1 as an inhibition target in preparation of an anti-enteritis drug. Researches show that the deletion of N4BP1 can alleviate colon pathological changes and weight loss caused by DSS, increase the survival days of mice, and reduce the generation of inflammatory factors and chemotactic factors. In addition, DSS can cause increase of N4BP1 expression in mice. Therefore, occurrence and development of enteritis can be inhibited by knocking out the N4BP1, the N4BP1 inhibitor or the N4BP1 neutralizing antibody, namely, the N4BP1 can become a new target spot for treating enteritis. Meanwhile, the expression of the N4BP1 can also be used as a new index for enteritis detection.

The invention belongs to the technical field of disease control in aquaculture, and particularly relates to a hippocampus enteritis pathogen separation and identification and medication screening method based on a high-throughput sequencing technology, which comprises the following steps: collecting intestinal tissues of a diseased hippocampus and a healthy hippocampus, respectively preparing tissue homogenate, and freezing for preservation; the method comprises the following steps: extracting DNA (Deoxyribose Nucleic Acid) of microorganisms of an intestinal tissue sample, performing 16SrDNA high-throughput sequencing, analyzing intestinal flora composition, and determining dominant bacteria; selecting and screening a culture medium according to dominant bacteria, and performing pathogenic bacterium separation and purification on intestinal tissues of the diseased hippocampus; dNA of the purified strain is extracted, 16S rDNA amplification and sequencing are carried out, and the species of pathogenic bacteria are identified through sequence comparison; according to the method, the diversity and abundance differences of microorganisms in the sick hippocampus and the healthy hippocampus are compared through a high-throughput sequencing technology, and targeted separation, identification and drug sensitivity screening are further carried out by taking statistically significant difference bacteria as the guidance of potential pathogenic bacteria.

The application discloses application of a natural oyster zinc peptide product in preparation of a medicine for preventing and treating enteritis. The application verifies the function of the natural oyster zinc peptide product in preventing and treating enteritis through animal experiments, the natural oyster zinc peptide product can improve the apparent symptoms of ulcerative colitis of mice caused by DSS by regulating the oxidation stress level, relieving the inflammatory reaction, maintaining the intestinal barrier and reducing the cell apoptosis, and the natural oyster zinc peptide product can also regulate the intestinal flora and metabolic products of the intestinal flora of the enteritis mice, so that the intestinal inflammation is relieved. The natural oyster zinc peptide product used in the application has good safety, compared with common anti-inflammatory and immunity-enhancing medicines, the natural oyster zinc peptide product has lower cost and no side effect, and the effect of relieving enteritis is remarkable. Therefore, the natural oyster zinc peptide product has a good prospect in development of medicines for preventing and treating enteritis.

The invention discloses a traditional Chinese medicine composition, a decoction, granules and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 5-15 parts of radix scutellariae, 3-7 parts of rhizoma coptidis, 5-15 parts of radix puerariae, 5-15 parts of radix paeoniae alba, 8-16 parts of radix angelicae sinensis, 5-15 parts of raw radix sanguisorbae, 10-20 parts of herba portulacae, 4-8 parts of radix aucklandiae and 3-7 parts of honey-fried licorice root. The traditional Chinese medicine composition not only can directly act on the cause of damp-heat, but also can comprehensively cover enteritis symptoms such as abdominal pain, diarrhea, tenesmus, bloody purulent stool and the like, can relieve the disadvantage that the stomach is injured by bitter and cold medicines, is strong in clinical pertinence, and is suitable for enteritis caused by ulcerative colitis, bacteria, viruses, radioactivity and the like; the traditional Chinese medicine composition can also be matched with probiotics to treat western medicine chronic diarrhea and traditional Chinese medicine diarrhea. Therefore, the traditional Chinese medicine composition or the decoction and the granules thereof have the prospect of being developed into the medicine for treating enteritis or the prospect of being developed into the medicine for treating western medicine chronic diarrhea and traditional Chinese medicine diarrhea in cooperation with the probiotics.

The invention discloses a probiotic biofilm gel microsphere as well as a preparation method and application thereof, and the probiotic biofilm gel microsphere is prepared by taking pectin, sodium alginate, escherichia coli Nissle1917 and iron-sulfur nano-enzyme as raw materials, preparing the raw materials through a microfluidic technology and then culturing the raw materials. The preparation method comprises the following steps: dissolving pectin and sodium alginate in deionized water, sequentially adding iron-sulfur nano-enzyme and Escherichia coli Nissle1917 into the deionized water, uniformly stirring, preparing through a microfluidic technology, and carrying out biological in-situ culture to make probiotics in the solution form a biological membrane. The cultured probiotic biofilm gel microspheres not only have the advantages of high stress resistance, good biocompatibility and the like, but also have good application prospects in the aspects of combined treatment and recovery of inflammatory enteritis and the like.

The invention provides a benzylimidazole glutamine cyclase inhibitor as well as a preparation method and application thereof, and belongs to the field of medical chemistry. The compound as shown in the formula I is prepared, the compound has good inhibitory activity on glutamine cyclase, and the half inhibitory concentration of most compounds reaches the nanomole level; the compound has a wide application prospect in preparation of drugs for treating Alzheimer's disease, depression, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, tumor, synovial membrane disease, gout, acute / chronic enteritis, rheumatoid arthritis or inflammatory diseases, and lays a material basis for research and development of related drugs.

The invention relates to a big data screening method of a traditional Chinese medicine compound for treating enteritis and application thereof, and belongs to the field of traditional Chinese medicine screening based on a data mining technology, animal experiment efficacy investigation and network pharmacology prediction. Comprising the following steps: performing data arrangement specification on a traditional Chinese medicine compound for treating enteritis based on a data mining technology; analyzing and summarizing the standardized data to obtain a new traditional Chinese medicine compound (AEND); constructing an acute enteritis mouse model, and performing pharmacodynamic evaluation on the traditional Chinese medicine compound; predicting the action mechanism of the screened traditional Chinese medicine compound based on a network pharmacology method; a molecular docking technology is applied to virtually verify the action target of the traditional Chinese medicine compound on acute enteritis; the pathway protein of a mammalian cell receptor tyrosine kinase mediated phosphatidylinositol related (PI3K / AKT) signal pathway is detected. According to the invention, a new formula AEND is screened out based on data mining, and a pharmacological experiment verifies that the AEND has a protective effect on mice with acute enteritis. The developed traditional Chinese medicine compound has the effects of resisting inflammation and regulating the homeostasis of intestinal flora.

The invention discloses an application of an AC13 compound or a pharmaceutical salt thereof in preparation of a medicine for treating enteritis. The structure of the AC13 compound is shown in the specification. The AC13 compound disclosed by the invention has a remarkable treatment effect on enteritis as a small molecule compound, and has the characteristics of low toxicity and remarkable curative effect. Therefore, the AC13 compound can be used as a lead compound of the major disease enteritis, has important development prospects and clinical application values, and also provides a scientific basis for further exploring the enteritis pathogenesis mechanism.

The invention provides an extract with high saikoside B2 content, a preparation method and application of the extract, and a combined medicine containing the extract, and belongs to the technical field of natural medicine preparation. The method comprises the following steps: efficiently extracting saikoside A and saikoside D in a radix bupleuri raw material by using an alkaline ethanol solution, further realizing efficient resolution of saikoside A and saikoside D by using macroporous adsorption resin, and quantitatively converting saikoside D into saikoside B2 by using a chemical method, thereby obtaining the high-content effective part of saikoside B2. The high-content effective part of saikoside B2 only contains a small amount of saikoside A except the main component saikoside B2, so that the toxicity is greatly reduced while the biological activity of the saikoside B2 is ensured. The high-content effective part of saikosaponin B2 can be used for preparing medicines for treating and preventing gout, rheumatoid arthritis, acute enteritis, skin light injury, skin inflammation and other diseases, can be independently used, and can also be combined with other medicines for use.

The present invention provides a drug for treating and / or preventing enteritis and / or hepatitis, said drug containing D-amino acid as an active ingredient. In addition, the present invention provides a food composition for suppressing enteritis and / or hepatitis, said composition containing D-amino acid as an active ingredient. In addition, the present invention provides a method for assisting diagnosis of enteritis and / or hepatitis in a subject, said method using the amount of D-amino acid in the intestinal tract as an indicator.

Provided herein are formulations for use in enteral tube feeding, that contain one or more whole food-based ingredients, mineral nutrients, small molecules, and / or large molecules, the combination of which is effective to bind bile acids when administered to a subject in need thereof. The combination of crafted ingredients for tube feeding reduce symptoms of gastroesophageal reflux, vomiting, abdominal pain, irregular stooling (diarrhea or constipation) and to reduce organ damage including pneumonia, pharyngitis, aspiration, esophagitis, gastritis and enteritis.

The invention discloses a construction method of a humanized enteritis mouse model, namely construction of an ulcerative colitis mouse model through DSS induction on an HSC-NCG-M / hIL15 immune reconstruction mouse, and belongs to the technical field of animal model construction. The method comprises the following steps: performing irradiation marrow removal on an NCG-M / hIL15 mouse, transplanting human hematopoietic stem cells and reconstructing, and then inducing ulcerative colitis by using DSS drinking water. The model constructed by the invention can better simulate the development process of IBD in a human immune system, solves the drug effect research defect caused by the difference between the existing mouse model and the human immune system, and provides a more accurate tool for IBD pathogenesis research and drug screening.

The invention belongs to the field of veterinary traditional Chinese medicines, and particularly relates to a veterinary traditional Chinese medicine oral liquid for treating chicken proventriculitis and enteritis and a preparation method thereof. The veterinary traditional Chinese medicine oral liquid for treating chicken proventriculitis and enteritis is prepared from the following raw materials: 20 to 25 parts of radix astragali seu hedysari, 8 to 12 parts of rhizoma atractylodis macrocephalae, 8 to 12 parts of radix sophorae flavescentis extract, 15 to 20 parts of herba andrographitis, 12 to 18 parts of rhizoma polygoni cuspidati, 10 to 15 parts of radix sanguisorbae, 10 to 15 parts of cortex ailanthi and 5 to 10 parts of radix glycyrrhizae. The veterinary traditional Chinese medicine oral liquid for treating chicken proventriculitis and enteritis has the advantages of definite curative effect, small side effect, convenience in use and the like, and the preparation method is simple and feasible, low in cost and convenient for large-scale popularization and application.

The invention belongs to the technical field of biological medicine, and discloses an enteritis targeted probiotic delivery system and a preparation method and application thereof, the system comprises: i) a recombinant plasmid for coding an anti-inflammatory functional protein, the plasmid comprising an anti-inflammatory peptide fragment, a surface protein modification and an antibiotic switch; ii) Escherichia coli chassis bacteria which are subjected to genetic engineering modification and have the capability of high yield of outer membrane vesicles; and iii) introducing the recombinant plasmid into the escherichia coli chassis bacterium to obtain a recombinant engineering bacterium. The delivery system disclosed by the invention can target intestinal inflammation parts, deliver anti-inflammatory proteins through the outer membrane vesicles, and specifically release anti-inflammatory factors in an inflammation microenvironment, so that intestinal inflammation response is relieved; according to the present invention, the method can achieve the precise targeting on the intestinal inflammation, can effectively control the remote delivery and the continuous secretion of the anti-inflammatory protein in space and time, has advantages of strong targeting property, lasting effect, small side effect and the like, and provides the new strategy for the safe and efficient treatment of the intestinal inflammation diseases.

The application discloses a sophora japonica composition for refractory enteritis and a preparation method and application thereof. The sophora japonica composition for refractory enteritis comprises the following components: sophora japonica, dried orange peel, panax notoginseng, momordica grosvenori and lycoris radiata, and the sophora japonica composition for refractory enteritis is obtained by fermenting plant lactobacillus. The sophora japonica composition for refractory enteritis of the application can obviously increase the amount of duhrlactobacillus, lactobacillus and bifidobacterium and reduce the amount of clostridium in the process of treating inflammatory enteritis; can effectively inhibit the inflammation of colitis, and the mRNA level of inflammatory cytokines TNF-alpha, IL-22, IL-1beta and IL-6 is obviously reduced. The sophora japonica composition can obviously inhibit intestinal inflammation, promote the metabolism of intestinal short-chain fatty acids, increase the thickness of intestinal mucosa, and has obvious curative effects on intestinal microecological homeostasis of inflammatory bowel disease, intestinal inflammation and protection of intestinal mucosa.

The invention discloses a Xianglian tablet with effects of clearing heat and drying dampness and a preparation method of the Xianglian tablet, and relates to the technical field of medicines. The tablet is prepared from coptis chinensis, radix aucklandiae, scutellaria baicalensis, parched white peony root, a rhizoma atractylodis extract, an IL-12 / IL-23 inhibitor with a specific structure, a filler, an adhesive, a disintegrating agent and a lubricant. The preparation method comprises the following steps: extracting traditional Chinese medicine water and volatile oil, mixing by an equivalent incremental method, granulating and drying, adsorbing volatile oil and tabletting. Through the synergistic effect of specific chemical drugs and traditional Chinese medicines, the IL-12 / IL-23 inflammatory pathway is accurately blocked, the anti-inflammatory activity and bioavailability are remarkably improved, and the pharmaceutical composition is used for treating dysentery, enteritis and ulcerative colitis caused by damp-heat accumulation.

The invention discloses porcine parvovirus disease and proliferative enteritis combined detection equipment, and belongs to the technical field of virus detection, the porcine parvovirus disease and proliferative enteritis combined detection equipment comprises a base, a shell is fixed on the outer side of the top of the base, a sample placing opening is formed in the front end of the shell, and a test paper carrier plate is horizontally arranged at the top of the sample placing opening and located on the shell. Two groups of limiting holes are formed in a sample placing plate, two EP tubes with samples can be stored during detection, a detection mode of parallel processing of the double samples is realized, then the samples are moved to the bottom of a grinding mechanism through a telescopic mechanism, and after the positions of the samples are fixed, the grinding mechanism is moved to the bottom of the grinding mechanism. The quantitative pumping and draining mechanism is used for automatically and quantitatively adding treatment liquid, then the grinding mechanism is used for simultaneously grinding two samples, and finally the dropwise adding mechanism is used for sucking and dropwise adding supernate of the samples onto test paper for simultaneous detection, so that the operation of the next sample does not need to be started after the process of a single sample is completed in the whole process; the operation time is greatly reduced, and the detection rate is improved.

Described herein are methods and compositions related to inhibiting bile salt hydrolase (BSH) and uses thereof. Provided herein is a method for treating a metabolic disorder (e.g., diabetes, obesity), gastrointestinal disease (e.g., a gastrointestinal infection; inflammatory bowel disease (IBD); appendicitis; Crohn's disease (CD); ulcerative colitis (UC); gastritis; enteritis; esophagitis; pancreatitis; diabetes; hepatitis; liver diseases (e.g., Non-alcoholic Fatty Liver Disease (NAFLD); non-alcoholic steatohepatitis (NASH); hepatitis A; hepatitis B; hepatitis C; autoimmune hepatitis; and cirrhosis of the liver) gastroesophageal reflux disease (GERD); celiac disease; diverticulitis; food intolerance; ulcer; infectious colitis; irritable bowel syndrome; leaky gut; and cancer), cancer (e.g., cancer of the digestive system, liver cancer), or an inflammatory disease (e.g., Crohn's disease, inflammatory bowel disease, ulcerative colitis, pancreatitis, hepatitis, appendicitis, gastritis, diverticulitis, celiac disease, food intolerance, enteritis, ulcer, gastroesophageal reflux disease (GERD), psoriatic arthritis, psoriasis, and rheumatoid arthritis) in a subject in need thereof comprising administering to a subject a compound of Formulae (I)-(XVIII).

The present application relates to the technical field of aquatic disease prevention and control, and particularly relates to a preparation method of a compound regulator for enteron inflammation of Pelteobagrus fulvidraco containing omega-3 fatty acid-lipoxin-phospholipid. The functional components of the compound regulator include eicosapentaenoic acid 20-30 parts, lipoxin B4 0.1-0.5 parts, phosphatidylserine 8-12 parts, dehydroabietic acid 1-2 parts, sophorobiose 10-18 parts and ethoxyquinoline 0.01-0.03 parts. The product integrates the functions of antibiosis, inflammation subsiding and tissue repair through a multi-target synergistic mechanism, and builds a complete inflammation regulation pathway. Meanwhile, the active ingredients are effectively protected by means of nano-liposome dosage form technology. The product realizes the antibiosis function by using natural ingredients. The technical scheme can solve the technical problems of low antibiosis efficiency, single mechanism and insufficient mucosal repair capacity of the existing prevention and control technology for enteron inflammation of Pelteobagrus fulvidraco, and has an ideal application prospect.

Provided is an examination method for irAE enteritis, said examination method comprising a detection step for detecting, as an indicator of ulcerous colitis-like irAE enteritis, an antibody that immunologically reacts with a fragment of, or the entirety of, integrin ανβ6 in a specimen.

This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a traditional Chinese medicine composition for treating diarrhea caused by spleen deficiency and damp-heat, and its application. The raw materials of the traditional Chinese medicine composition of this invention include five-finger peach, codonopsis, Chinese yam, white cardamom, agastache, light bamboo leaf, plantain, broom leaf, firethorn, kapok flower, frangipani, tangerine peel, citronella, bergamot, clematis, roasted rice sprouts, roasted radish seeds, euryale seed, schisandra fruit, pomegranate peel, and prepared licorice root. All are inexpensive and readily available traditional Chinese medicinal materials, natural and safe, with no toxic side effects. The traditional Chinese medicine composition of this invention is formulated under the guidance of classical traditional Chinese medicine theory, with a scientific and rational combination. The combined effects of these herbs are to invigorate the spleen and replenish qi, clear heat and remove dampness, astringe the intestines and stop diarrhea. It treats the root cause of the disease, addressing both the symptoms and the underlying cause, and has a unique therapeutic effect on diarrhea caused by spleen deficiency and damp-heat (especially diarrhea-predominant irritable bowel syndrome, chronic enteritis, and functional diarrhea), with no obvious adverse reactions observed, showing good application prospects.

The present application relates to the technical field of feed, in particular to a plant extract for preventing and treating enteritis of livestock and poultry, an additive and application thereof.The plant extract is a water extract of a plant raw material composition, and the plant raw material composition comprises plantain, radix codonopsitis, tuckahoe, white atractylodes, dried ginger, orange peel, spiny amaranth and licorice.The plant extract for preventing and treating enteritis of livestock and poultry has no antibiotic and chemical synthetic drug, has good prevention and treatment effect on enteritis of livestock and poultry, has the effects of invigorating the spleen and stomach, astringing the intestines to stop diarrhea and stopping dysentery, and has no biological toxicity.

The invention belongs to the technical field of livestock and poultry feed additives, and particularly relates to application of a dogwood extract in preparation of a compound feed for relieving diarrhea and enteritis, and the dogwood extract is an aqueous extract of a dogwood medicinal material. 500mg-2000mg of the dogwood extract is added into each kilogram of the basal feed, so that the compound feed is obtained. The compound feed can relieve diarrhea and intestinal inflammation of weaned piglets, especially at the 21-35-day-old stage, the diarrhea occurrence rate of the weaned piglets can be remarkably reduced by 15% or above, meanwhile, the average daily gain is increased, the feed-gain ratio is reduced, the comprehensive growth performance is better than that of a control group, the level of pro-inflammatory cytokines in IPEC-J2 cells or intestinal mucosa tissues is remarkably reduced, and the weaned piglets are prevented from suffering from diarrhea and intestinal inflammation. Meanwhile, the level of anti-inflammatory cytokines is up-regulated, and excessive activation of an NF-kB key inflammatory signal channel can be inhibited.