243 results about "Enteritis" patented technology

The invention provides lactobacillus reuteri HNU872 and application of the lactobacillus reuteri HNU872 in preparation of intestinal inflammation related products. The invention discloses how the Lactobacillus reuteri HNU872 effectively alleviates the phenotype of DSS-induced mouse enteritis. The invention also discloses a preparation method of the Lactobacillus reuteri HNU872. Research results show that the Lactobacillus reuteri HNU872 can significantly relieve weight loss caused by enteritis, improve colon length, significantly improve the level of anti-inflammatory cytokines in serum and reduce the concentration of pro-inflammatory cytokines. In addition, the expression of the intestinal tight junction protein ZO-1 is obviously promoted. The lactobacillus reuteri HNU872 can regulate diversity and structure of intestinal microbiota of mice, inhibit enrichment of pathogenic bacteria and relieve inflammatory response. According to the invention, the action mechanism of the lactobacillus reuteri HNU872 in improving enteritis is clarified, and a solid scientific basis is provided for developing a microbial product based on probiotics as an alternative treatment strategy for ulcerative colitis.

The invention relates to the technical field of functional microorganism screening and application, and particularly provides a strain of lactobacillus plantarum and an application of the lactobacillus plantarum in improvement of intestinal inflammation and repair of intestinal mucosa injury. The plant lactobacillus is preserved in the China General Microbiological Culture Collection Center (CGMCC for short) on August 1, 2024, the address is No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number of the plant lactobacillus is CGMCC No.31521. The strain has remarkable antioxidant, bacteriostatic and anti-inflammatory effects, can repair intestinal barrier injury of mice with colitis, promote renewal of intestinal stem cells, promote growth of intestinal beneficial bacteria and inhibit proliferation of harmful bacteria, can be widely applied to prevention and treatment of enteritis, and has a wide market prospect.

The invention discloses lactobacillus plantarum capable of relieving enteritis and toxicity of polystyrene nano-plastics, and the preservation number of the lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) NO.31420. The lactobacillus plantarum can be used for relieving enteritis and toxicity of polystyrene nano-plastics. The strain is obtained by separating and purifying baby feces, and can grow on an MRS culture medium, and the bacterial colony is round, off-white, smooth and opaque. Experiments show that the lactobacillus plantarum can effectively adsorb PS-NPs, promote the PS-NPs to be discharged along with excrement, reduce accumulation of the PS-NPs in organs, and significantly reduce toxicity and inflammatory response of organs such as liver and kidney of mice. In addition, the strain can repair the intestinal barrier function, regulate liver metabolism and relieve enteritis symptoms. The invention further provides a probiotic preparation containing the strain, and the probiotic preparation can be prepared into granules, capsules, tablets or oral liquid and the like and is used for preventing or treating intestinal injury and inflammatory diseases caused by PS-NPs. The strain is safe and efficient, and has a wide application prospect.

The invention relates to the technical field of fermentation, in particular to a strain of lactococcus gasseri ZB15, an acellular fermentation freeze-dried substance with anti-inflammatory activity and a preparation method of the acellular fermentation freeze-dried substance. The Lactococcus garvieae ZB15 is preserved in the Guangdong Microbial Culture Collection Center, the address is the 5th floor of building 59, No.100 Courtyard, Xianlie Middle Road, Guangzhou, Institute of Microbiology, Guangdong Academy of Sciences, the preservation date is February 27, 2025, and the preservation number is GDMCC No: 65947. The lactococcus gasseri ZB15 disclosed by the invention is prepared into an acellular fermentation freeze-dried substance, and the acellular fermentation freeze-dried substance can improve the body immunity by changing the intestinal microflora structure while relieving and improving enteritis, so that a basis is provided for the preparation of enteritis medicines.

The invention discloses a synbiotics composition with bacteriostatic and anti-inflammatory effects, which comprises probiotics and prebiotics in parts by weight, the probiotics comprise the following components in parts by weight: 0.05 to 0.15 part of freeze-dried powder of lactobacillus rhamnosus PB-LR76, 0.05 to 0.15 part of freeze-dried powder of lactobacillus acidophilus HH-LA26, 0.05 to 0.15 part of freeze-dried powder of lactobacillus bulgaricus HH-LB57, 0.05 to 0.15 part of freeze-dried powder of bifidobacterium lactis HH-BA68, 0.05 to 0.15 part of freeze-dried powder of lactobacillus reuteri PB-LR09, and 0.05 to 0.15 part of freeze-dried powder of lactobacillus plantarum HH-LP56; the prebiotics are fructo-oligosaccharide or a rhizoma polygonati extract. Compared with the single use of probiotics or prebiotics, the synbiotics composition disclosed by the invention has stronger antibacterial and anti-inflammatory effects. The invention further discloses application of the synbiotics composition in preparation of a medicine for treating enteritis.

The invention provides a cobalt monatomic nano-enzyme system modified by phospholipid polyethylene glycol carboxyl. The cobalt monatomic nano-enzyme system comprises a cobalt monatomic nano-enzyme composite core and phospholipid polyethylene glycol carboxyl compounded on the surface of cobalt monatomic nano-enzyme, the cobalt monatomic nano-enzyme composite core comprises a cobalt monatomic nano-enzyme and ginsenoside loaded on the cobalt monatomic nano-enzyme. The invention also provides a bifidobacterium synergetic cobalt monatomic nano-enzyme system which is formed by combining cobalt monatomic nano-enzyme with ginsenoside Rb1 and further delivering the cobalt monatomic nano-enzyme and ginsenoside Rb1 through bifidobacterium bifidum for targeted therapy of enteritis. The combination of Co SA and Rb1 can enhance the anti-inflammatory efficacy by adjusting a key immune signal pathway, and bifidobacterium bifidum can ensure targeted delivery of microbiota and promote intestinal barrier repair. The synergistic three-component strategy integrating monatomic nano-enzyme antioxidation, natural drug immunoregulation and probiotic targeting is provided, and a promising treatment platform is provided for accurate intervention of IBD.

The invention provides an application of a compound Aldometanib in preparation of a medicine for preventing and treating immune-related adverse reactions and diseases. Based on the first discovered prevention and treatment effects of Aldometanib on fatal immune hepatitis, immune myocarditis, pneumonia and enteritis, the invention specifically discloses application of Aldometanib in preparation of drugs for prevention and treatment of immune-related adverse reactions and diseases, and the main mechanism is that Aldometanib activates immune cells AMPK, enhances catabolism of immune cells, promotes immune cell apoptosis, promotes immune cell apoptosis, and improves immune cell apoptosis. The anabolism of the immune cells is inhibited, so that the expression of effector factors of the immune cells is controlled, and inflammatory factor storm is inhibited. Aldometanib has the effects of preventing the occurrence of immune-related adverse reactions and diseases, and inhibiting the attack levels of the immune-related adverse reactions and diseases, so that non-lethal and lethal injuries caused by an immune system to body organs are reduced.

The invention discloses a construction method of an anti-oxidation adhesion type genetically engineered bacterium, the engineering bacterium and application of the engineering bacterium, and relates to the technical field of construction of the anti-oxidation adhesion type genetically engineered bacterium. According to the invention, superoxide dismutase and catalase are subjected to constitutive overexpression in a probiotic chassis by using a synthetic biological technology, and meanwhile, intestinal trefoil factor peptide fused pilin is subjected to overexpression. According to the present invention, the research results show that the active oxygen scavenging ability of the anti-oxidation adhesion type gene engineering probiotic is significantly improved, the adhesion ability of the anti-oxidation adhesion type gene engineering probiotic in the animal intestinal tract is significantly enhanced, and the radiation enteritis symptom caused by the whole abdomen ionizing radiation irradiation can be effectively relieved; the strain can be used as a potential safe viable bacterium medicine for preventing and treating radiation enteritis and other active oxygen related enteritis. The anti-oxidation adhesion type genetic engineering probiotics can be prepared into viable bacteria preparations such as viable bacteria suspension, dairy products, viable bacteria powder, bacterial tablets or capsules, can be proliferated and colonized in human intestinal tracts after being orally taken, and is applied to prevention and treatment of radiation enteritis.

The invention relates to the technical field of microorganisms, in particular to lactobacillus rhamnosus capable of preventing or treating inflammatory bowel diseases and promoting digestion and application of the lactobacillus rhamnosus, and belongs to the technical field of biological medicine. The invention provides a strain of lactobacillus rhamnosus R7970, wherein the preservation number of the lactobacillus rhamnosus R7970 is CGMCC (China General Microbiological Culture Collection Center) 22244, and the preservation number of the lactobacillus rhamnosus R7970 is CGMCC 22244. The lactobacillus rhamnosus R7970 can be used for effectively preventing inflammatory enteritis (IBD) and has a prevention effect on intestinal inflammation, and meanwhile, the lactobacillus rhamnosus R7970 can be used for improving the nutrition digestion and absorption functions of intestinal tracts. Therefore, the lactobacillus rhamnosus R7970 can be applied to prevention of IBD, can be used for preparing probiotic preparations, common foods, health foods and biological pharmacy for improving intestinal health, is convenient for industrial production, and has great popularization value.

The invention relates to the technical field of biomedical engineering, in particular to engineered probiotics with a surface-modified protective shell, a preparation method and application of the engineered probiotics, the engineered probiotics with the surface-modified protective shell comprise the protective shell and engineered probiotics, and the engineered probiotics are coated with the protective shell; the engineered probiotics are subjected to surface modification through immune regulation factors, and metal ions are loaded on the surfaces of the engineered probiotics subjected to surface modification; the engineered probiotics with the surface modified protective shell can regulate immune factors, can be targeted and colonized in colon and promote repair of mucosa surface, and has a better treatment effect on enteritis, so that the engineered probiotics are expected to be applied to preparation of enteritis pharmaceutical preparations; according to the preparation method of the engineering probiotics, raw materials are easy to obtain, the operation process is simple and convenient, reaction conditions are controllable, and large-scale production is facilitated.

The invention belongs to the technical field of medicine, and particularly relates to a medicine for treating or preventing chicken coccidiosis and chicken necrotic enteritis and application, the medicine is chaulmoogratree seed, and can be in the form of medicinal material powder or chaulmoogratree seed extract. The traditional Chinese medicine composition can be used for preventing and treating chicken coccidiosis diseases, reducing the death rate of broilers with necrotic enteritis and intestinal lesions of necrotic enteritis, effectively improving chicken necrotic enteritis and has a good popularization and application prospect in the aspect of preventing and treating chicken necrotic enteritis diseases; the traditional Chinese medicine composition has a good treatment effect on mixed infection diseases of small intestine coccidiosis and clostridium.

The invention belongs to the field of microorganisms, and particularly relates to lactococcus lactis Jlus 880314 and application thereof. The strain is classified and named as Lactococcus lactis, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing; the preservation number of the strain is CGMCC No. 33961. Time-of-flight mass spectrometry analysis shows that nisin exists in a metabolite of the strain, and the strain can be used for producing nisin. The compound shows an excellent and wide antibacterial function in antibacterial experiments, can be used for preparing antibacterial drugs, particularly has a remarkable inhibiting effect on growth of gram-negative bacteria and fungi, can be used for preparing drugs for relieving or treating enteritis, or preparing drugs, nourishment or health care products for regulating gastrointestinal tract micro-ecological balance of people or animals, and can be used for preparing medicines for relieving or treating enteritis. The compound can also be used for preparing antibacterial food additives and / or animal feed additives. A hemolysis experiment result shows that hemolysis is avoided, toxic and side effects are small, and wide development prospects and application values are achieved.

The invention discloses a composite probiotic inulin gel biomass preparation as well as a preparation method and application thereof. Relates to the technical field of food. The raw materials comprise composite probiotics and inulin gel. The invention further provides a preparation method and application. The oral compound probiotic inulin gel preparation provided by the invention is good in safety, and is used for preventing ionizing radiation hematopoietic system injury and radiation enteritis; wherein the inulin gel has a certain protection effect on gastric acid and intestinal juice, and probiotics are protected from being damaged. The inulin gel can prolong the retention of the probiotics in the intestinal tract and enhance the colonization effect of the probiotics in the intestinal tract. The compound probiotics have a certain synergistic effect.

The invention discloses a plant lactobacillus Kimate-F, a plant lactobacillus Kimate-6, a composite probiotic composition composed of the plant lactobacillus Kimate-F and the plant lactobacillus Kimate-6, and an application of the composite probiotic composition in relieving dog transportation stress and improving dog enteritis. The probiotic composition can effectively relieve dog transportation stress and remarkably reduce indexes such as corticosterone and active oxygen. In addition, the probiotic composition can effectively prevent or relieve canine enteritis, promote reproduction of beneficial bacteria in intestinal flora, inhibit proliferation of potential harmful bacteria, repair intestinal mucosal barrier and reduce inflammatory response. The invention has a wide application prospect, is especially suitable for dogs with long-distance transportation, stress susceptibility and poor intestinal function, and can also be used in cooperation with other conventional treatment means.

The invention discloses a CuS / PGS-PSBMA-calcium alginate hydrogel microsphere for treating inflammatory bowel disease and a preparation method thereof, and the preparation method of the oral hydrogel microsphere comprises the following steps: (1) crosslinking CuS / PGS and PSBMA, and preparing the CuS / PGS-PSBMA hydrogel microsphere by adopting an air flow control technology; and (2) performing calcium ion diffusion cross-linking to obtain a core-shell structure hydrogel microsphere with calcium alginate as a shell and CuS / PGS-PSBMA as a core, thereby obtaining the CuS / PGS-PSBMA-calcium alginate hydrogel microsphere for treating the inflammatory bowel disease. The core-shell structure hydrogel microsphere for treating the inflammatory bowel disease is prepared by utilizing an air flow control technology and an ion diffusion method, can be accurately dissolved and release hydrogel at the colon part after being orally taken, and is adhered to the local intestinal wall to promote polarization of intestinal M2 macrophages, so that the inflammatory bowel disease is treated, and the curative effect is good. The medicine is a safe and multi-effect enteritis treatment medicine with clinical transformation significance.

The invention provides a strain of high-temperature-resistant and inflammation-relieving Witzia ciliaris and an application thereof, the high-temperature-resistant and inflammation-relieving Witzia ciliaris is Witzia ciliaris CN985 and is preserved in the China Center for Type Culture Collection (CCTCC), the preservation date is April 7, 2024, and the preservation number is CCTCC NO: M 2024641. The invention further provides a preparation method of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain for preventing and treating inflammation of the high-temperature-resistant and inflammation-relieving Witzia ciliaris strain. The invention provides a brand new strain of Witzia ciliaris CN985, which is resistant to high temperature, has better acid resistance and bile resistance, and has no hemolysis risk when being applied to a human body. The Witzia coagulans CN985 has excellent antibacterial performance, and especially can significantly inhibit streptococcus pyogenes, salmonella enteritidis and / or group B streptococcus; besides, experimental results show that the Witzia ciliaris CN985 can relieve enteritis, improve the immunity of the organism and relieve pharyngitis, and especially when the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 are combined for use, the Witzia ciliaris CN985 and the phytobacterium plantarum CE18 have a synergistic interaction effect, so that the relieving effect on enteritis can be remarkably improved.

To provide a diagnostic support method for enteritis in a simple and non-invasive manner.SOLUTION: Provided is a diagnostic support method for enteritis in a subject, comprising: measuring the concentration of hydrogen in a gas mixture discharged from the subject; and comparing the measured value or the standard deviation of the measured value with a reference value.SELECTED DRAWING: Figure 4

The present invention provides a strain of the genus Alistipes as well as a pharmaceutical composition comprising the strain or an extract of the strain. The strain and the pharmaceutical composition disclosed by the invention can be used for remarkably relieving such symptoms as weight loss, shortened colon length, inflammatory factor release and the like of an enteritis object, and do not have toxic or side effects. Therefore, the another mycobacterium strain or the active extract of the another mycobacterium strain can be used for preparing pharmaceutical compositions and fermented foods for relieving enteritis, and has a very wide application prospect.

The invention discloses a magnesium boride nanosheet / inulin composite hydrogel and application thereof in treating inflammatory bowel diseases and complicated mental diseases, and the composite hydrogel is synthesized by doping magnesium boride nanosheets into inulin and carrying out hot melting and cooling to form gel. The composite hydrogel has good oxidation resistance and biocompatibility, reducing hydrogen can be generated through a hydrolysis reaction to be used for reducing active oxygen and inflammatory factors of the enteritis part, intestinal flora can be adjusted, meanwhile, the composite hydrogel can be prevented from being affected by gastric acid and reach the intestinal part through the addition of inulin, and the enteritis treatment effect is improved. Therefore, the inflammatory bowel disease and related anxiety and depression symptoms thereof are effectively treated.

The invention discloses a phagocytosis-resistant indigo engineering strain, which can sensitively respond to enteritis-related thiosulfate inflammatory factors, timely release a drug indigo to treat gastrointestinal inflammation, and release sfGFP signal molecules to assist in diagnosis and monitoring of diseases, and is very helpful for slowing down disease progression. In addition, through knockout of fhuA and trxA genes related to bacteriophage infection and knockin of an sspB-sspC-sspD-sspE gene cluster, the survival rate of the strain in the intestinal tract can be improved, and the treatment and diagnosis effects of the strain are improved.

The invention provides a decapterus maruadsi deepwater net cage culture method, and belongs to the technical field of decapterus maruadsi culture. According to the method, the submersible net cage is adopted, the decapterus maruadsi is located in the optimal growth water layer at the temperature of 20-25 DEG C all the year round according to rising and falling of seasons (surface water temperature), a guide pipe is adopted for fixed-point feed feeding, and the feed coefficient is reduced to 1.25 or below. According to the method, a water temperature-feeding amount-allicin-probiotics coupling model is established, the enteritis incidence rate in the high-temperature period is controlled within 2%, and annual continuous growth of decapterus maruadsi in deep and far sea is achieved.

The invention relates to the technical field of medical image processing, and discloses a digestive enteritis pathological section image adaptive feature processing method. The method comprises the following steps: constructing a multi-scale feature analysis model based on histological features of a digestive enteritis pathological section to extract texture features and morphological features of different tissue levels in the pathological section; then constructing an adaptive feature optimization strategy, and dynamically adjusting feature selection parameters according to feature data output by the multi-scale feature analysis model; then performing joint operation on the multi-scale feature analysis model and the adaptive feature optimization strategy according to the selected pathological section sample type to obtain an optimized feature data set; and finally, according to the optimized feature data set, establishing feature representation of the digestive enteritis pathological section image. The method can comprehensively extract pathological features, dynamically optimize feature selection parameters, improve feature data set quality and feature characterization accuracy, adapt to different sample types and meet pathological analysis requirements.

Provided herein is a method for inspecting irAE enteritis, comprising a detection step for detecting an antibody that immunologically reacts with a fragment or all of integrin [alpha] v [beta] 6 in a sample as an indicator of ulcerative colitis-like irAE enteritis.

The invention relates to a novel polypeptide and application thereof. The polypeptide provided by the invention is short in peptide chain and faster and better in absorption. Experimental results show that the polypeptide provided by the invention shows an obvious enteric cavity dilatation relieving effect in pharmacodynamic tests of a zebra fish inflammatory bowel disease model and a rat inflammatory bowel disease model. The polypeptide provided by the invention has a remarkable colitis relieving effect, and can be used for preparing a medicine for treating enteritis, especially a medicine for treating ulcerative colitis.

The present invention relates to a new polypeptide and its application. The polypeptide provided by the present invention has a short peptide chain and is absorbed faster and better. Experimental results show that the polypeptide provided in this application exhibits an obvious effect of alleviating intestinal lumen dilation in the zebrafish inflammatory bowel disease model and the rat inflammatory bowel disease model. The polypeptide provided by the present invention has a significant effect of alleviating colitis and can be used to prepare drugs for treating enteritis, especially drugs for ulcerative colitis.

The invention relates to an enhanced adipose-derived mesenchymal stem cell and application thereof in preparation of a medicine for treating enteritis, and belongs to the technical field of cell biology. The invention provides an enhanced adipose-derived mesenchymal stem cell. The enhanced adipose-derived mesenchymal stem cell is an adipose-derived mesenchymal stem cell of an overexpressed CNDP2 gene. According to the method, only a carrier for expressing the CNDP2 gene needs to be transfected in the adipose-derived mesenchymal stem cells, a complex and difficult-to-control gene editing technology is not needed, the operation is simple and easy, and the operation can be completed in a common laboratory, so that the aging process of the adipose-derived mesenchymal stem cells can be delayed, and the in-vitro culture activity and the in-vivo enteritis resistance of the adipose-derived mesenchymal stem cells can be enhanced. The experimental period is short, the use condition is not harsh, and clinical application can be better adapted.

The invention provides application of CD84 as a therapeutic target in preparation of drugs for preventing and treating inflammatory bowel diseases, and belongs to the technical field of biological medicines. The CD84 is applied to development, screening or preparation of drugs for preventing and / or treating inflammatory bowel diseases as a therapeutic target. According to the application, a dextran sodium sulfate (DSS)-induced inflammatory bowel disease classical animal model is taken as an experimental subject, and the anti-CD84 antibody is taken as a drug to block the biological function of CD84, so that the degree of DSS-induced mouse enteritis can be effectively relieved, the colorectal length can be recovered, and the secretion level of inflammatory factors can be reduced. Therefore, a new strategy is provided for targeted therapy of the inflammatory bowel disease by taking the CD84 as a therapeutic target.

The invention discloses a traditional Chinese medicine navel pill for treating constipation, diarrhea and chronic enteritis and a preparation method of the traditional Chinese medicine navel pill, and belongs to the technical field of traditional Chinese medicine. The preparation method comprises the following steps: weighing the raw materials, mixing, crushing and sieving to obtain mixed medicine powder, adding honey into the mixed medicine powder, stirring and kneading until the mixture is sticky, and preparing pills. The navel pill is applied to the navel, two-way conditioning of constipation and diarrhea is achieved through the synergistic effect of traditional Chinese medicine, chronic enteritis can be treated in a targeted mode, intestinal mucosa is effectively repaired, the intestinal inflammation state is improved, the navel pill has the advantages of being safe and convenient to apply, high in bioavailability, mild and free of side effects, stimulation of oral medicine to gastrointestinal tracts is avoided, and the curative effect is good. The food is suitable for digestion function conditioning of different people.

The present application provides a kind of complex probiotic paste, which combines Enterococcus faecalis, Saccharomyces cerevisiae and vitamin B 12 Producing lactic acid bacteria of canine source, adds prebiotics, flavoring substances and auxiliary substances such as paste matrix preparation.In the paste, the viable count of Enterococcus faecalis, Saccharomyces cerevisiae and lactic acid bacteria is 1-2:1-2:1-8;Paste matrix includes fructooligosaccharide 0.5-3%, psyllium husk powder 0.1-2%, goat milk powder 2-8%, chicken liver powder 1-5%, potassium sorbate 0.5-2%, xanthan gum 1-4%, and the balance is water.The above-mentioned complex probiotic paste can be stably stored for 56 days at 4 DEG C and normal temperature dry place, has good storage stability, good safety, and can adjust intestinal flora and increase the content of intestinal lactic acid bacteria.The above-mentioned complex probiotic paste has good palatability and oral tolerance for pets such as dogs and cats, and has good therapeutic effect on DSS-induced chronic enteritis diarrhea and vitamin B 12 Deficiency.

The present invention relates to the use of an animal feed additive composition for controlling the growth of undesirable microorganisms, said composition comprising glycerides, vegetable oils, tannins and / or saponins, the glycerol ester is selected from the group consisting of glycerol monopropionate, glycerol dipropionate and glycerol tripropionate, glycerol monobutyrate, glycerol dibutyrate and glycerol tributyrate, glycerol monovalerate, glycerol divalerate and glycerol trivalerate, and mixtures thereof. The invention also relates to the use of the animal feed additive composition for promoting intestinal growth, alleviating or alleviating effects from necrotizing enteritis, modulating intestinal flora and / or as an additive to drinking water.