The invention relates to the field of biomedicine, and provides liposome enhanced hydrogel and application thereof. The enhanced hydrogel is mainly prepared from hydrogel materials or blank or medicine carrying liposome through blending crosslinking; the hydrogel materials are selected from hyaluronic acid aquagel, cellulose aquagel, alginate aquagel, collagen aquagel, polyester aquagel, polyvinyl alcohol aquagel, collagen grafted polyacrylate aquagel, hyaluronic acid grafted N-isopropylacrylamideaquagel or unsaturated methacrylate modified gelatin; the addition quantity of the liposome is 1 to 150mg / mL of hydrogel system reclaimed water. The hydrogel provided by the invention has the advantages that the mechanical property is enhanced; the load and regulation and control release of different medicine can be realized, so that the multifunction of tissue repair and disease treatment is realized.