334 results about "Caffeine" patented technology

Examples relate to a fatigue detection system to monitor and assess pilot fatigue levels during flight operations. An example system includes a wearable biometric sensor (WBS) integrated into a wristband that captures biometric data from the pilot. A processor analyzes the captured data to determine the pilot's fatigue level. When this level exceeds a predetermined threshold, the system provides an alert to the pilot through a haptic feedback mechanism in the wristband. Additionally, the system generates personalized fatigue mitigation advice, which is displayed on an electronic flight bag (EFB) application accessible to the pilot. The advice may include recommendations for taking a controlled rest, consuming caffeine, or engaging in physical activity. The system enhances flight safety by providing real-time alerts and actionable advice to combat pilot fatigue.

The invention provides a dihydroquercetin caffeine eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. The structural formula of the dihydroquercetin caffeine eutectic crystal is as shown in formula I. The dihydroquercetin caffeine eutectic crystal has excellent water solubility, so that the dihydroquercetin caffeine eutectic crystal has ideal compatibility and bioavailability.

The invention relates to an external composition for hair growth regulation and a preparation method thereof, and belongs to the technical field of cosmetics and medicines. The composition disclosed by the invention comprises nano mesoporous carbon for enhancing permeation, various surface functional modifications on the nano mesoporous carbon, minoxidil, protein fragments, polypeptides, oligopeptides, amino acids, dutasteride, bimatoprost, traditional Chinese medicine extracts, vitamins, caffeine, nucleosides, growth factors and various auxiliary functional components. Wherein the pore diameter of mesopores of the nano mesoporous carbon for enhancing permeation is 2-30 nm, the total pore volume of the mesopores is 1.5-3.5 cm < 3 > / g, and the particle size of the nano mesoporous carbon is 50-200 nm. The prepared nano mesoporous carbon is granular, controllable in size, stable in structure, free of irritation to skin, capable of keeping inert to various active ingredients in the composition, capable of enhancing absorption and permeation of other ingredients on the skin, wide in application range, capable of compounding various types of active ingredients and high in biological safety.

The invention discloses a hair follicle targeting nano-liposome anti-hair loss and hair growth compound preparation. The compound preparation is prepared from the following raw materials in parts by mass: 70 to 85 parts of bionic liposome carrier and 15 to 30 parts of active ingredients, the bionic liposome carrier is prepared from 50 to 60 parts of egg yolk lecithin, 15 to 20 parts of pH sensitive phospholipid DOPE, 10 to 15 parts of cholesterol and 5 to 10 parts of mesenchymal stem cell exosome membrane protein; the active ingredients comprise 5 to 10 parts of minoxidil, 3 to 5 parts of caffeine, 0.5 to 1 part of miR-218-5p, 1 to 2 parts of biotin and 2 to 3 parts of quercetin; the average particle size of the nano-liposome formed by the bionic liposome carrier is 120-180nm, and the polydispersity index (PDI) is less than or equal to 0.15. The invention relates to the technical field of biological medicines, in particular to a hair follicle-targeted nano-liposome anti-hair loss and hair growth compound preparation, which has the following advantages due to the adoption of the technical scheme: accurate targeted delivery is realized, and the treatment safety and accuracy are improved; intelligent response release is achieved, and the local microenvironment of hair follicles is optimized; the multi-target synergistic effect breaks through the limitation of single treatment.

The invention discloses a taste receptor derived peptide capable of effectively detecting caffeine and a biosensor, and belongs to the technical field of biosensors. Currently, traditional spectrum and chromatography on which caffeine detection depends have the problems of expensive instruments, time-consuming detection, complex procedures and the like, and a sensor based on a taste receptor is also faced with the limitations of high cost, complex preparation process and easy inactivation of the receptor. In order to solve the problem, the taste receptor derived peptide provided by the invention has an amino acid sequence as shown in SEQ ID NO: 4, the biosensor comprises a substrate and a disc interdigital electrode, and a carbon nanotube is firmly attached to the electrode and is connected with the taste receptor derived peptide. The biosensor can specifically detect caffeine in a beverage, has no response to other substances, and has application potential in the fields of food quality control, clinical drug monitoring, public health safety assessment and the like.

The invention discloses a caffeine-free tea-flavored concentrated solution, and relates to the field of food processing. The caffeine-free tea-flavored concentrated solution comprises an aroma extracting solution A and a taste concentrated solution B. The aroma extracting solution A and the taste concentrated solution B are compounded, blended and refined to prepare the caffeine-free tea-flavored concentrated solution. The aroma extracting solution A is prepared through the steps of raw material treatment, low-temperature vacuum steam extraction and condensation collection, and the taste concentrated solution B is prepared through the steps of Roebos tea pretreatment, water extraction concentration and enzymolysis synergy. According to the caffeine-free tea flavor concentrated solution, through the synergistic effect of supercritical carbon dioxide fragrance removal and natural caffeine-free Roibos tea, the caffeine content of a final product is lower than the detection limit and is far lower than the residue level of a traditional method. The low-temperature vacuum steam extraction avoids degradation of heat-sensitive aroma components, and the condensation collection technology is combined, so that the retention rate of volatile aroma components is high and is obviously superior to that of a supercritical carbon dioxide method.

The invention discloses a siraitia grosvenorii instant coffee beverage assisting in reducing uric acid and a preparation method thereof, and belongs to the technical field of food based on the theory of homology of medicine and food. The coffee beverage is composed of instant coffee powder, a compound sweetening agent, coconut milk powder, milk powder and composite herbal powder in a specific proportion. The compound herbal powder is composed of poria cocos, peach kernels, dried tangerine or orange peel and momordica grosvenori which are selected from a medicinal and edible substance catalog. The herbal active ingredients and a coffee system are deeply fused by optimizing an extraction process, the dual regulation effects of inhibiting xanthine oxidase and promoting uric acid excretion are synergistically exerted, and the technical contradiction that common caffeine possibly affects uric acid excretion is effectively solved. The zebra fish in-vivo experiment proves that the level of uric acid can be remarkably reduced (Plt: 0.001), the improvement rate is as high as 17.63%, and a safe and effective daily diet intervention scheme is provided for people with hyperuricemia while the coffee flavor and convenience are provided.

The invention relates to an anti-fatigue refreshing functional chewing gum containing natural active ingredients, which relates to the technical field of food, and comprises a gum base, a natural sweetening agent and an active ingredient mixture, the mustard extract and coffee are innovatively combined to form a dual-channel nerve activation mechanism, the mustard extract realizes instant refreshing through a targeted oral trigeminal nerve TRPA1 ion channel, caffeine maintains continuous excitation through antagonism of a central adenosine receptor, and the space-time cooperation of the mustard extract and the coffee breaks through the limitation of a single path. Meanwhile, a rhodiola rosea extract, a sea-buckthorn extract, an American ginseng extract and astragalus polysaccharide are compounded, so that a triple anti-fatigue physiological barrier with functions of nerve regulation, oxidative stress inhibition and energy metabolism optimization is formed. In the preparation process, a microcapsule embedding technology is adopted to control slow release of mustard active ingredients, menthol flavor is combined to synergistically trigger TRP channel dual activation, and unification of efficacy and palatability is achieved.

The invention discloses a composition with sensitive skin repairing and anti-aging functions as well as an emulsion and application of the composition, and belongs to the technical field of cosmetics. The composition specifically comprises a pseudoalteromonas fermentation product extract, collagen, palmitoyl tripeptide-5, acetylchitosamine, sodium hyaluronate, silanetriol, caffeine and acetyl hexapeptide-8, and can promote the generation of laminin-5 and integrin beta1, promote the vitality of keratinocytes and fibroblasts, inhibit the growth of the keratinocytes and the fibroblasts, inhibit the growth of the keratinocytes and the fibroblasts, inhibit the growth of the keratinocytes and the fibroblasts, and promote the growth of the keratinocytes and the fibroblasts. The generation of inflammatory factors (IL-6) is inhibited; the generation of collagen IV and collagen VII is promoted; the invention further provides an emulsion prepared from the composition, and the optimal formula of the emulsion is obtained through optimization. The active composition disclosed by the invention has a wide application prospect in the field of cosmetics, and particularly has important significance in sensitive skin repair and anti-aging directions.

An apparatus and method for selectively adding additional ingredients, e.g., liquids or powders such as caffeine, vitamins, flavorings, supplements, to a liquid beverage in a container, the container includes at least one side portion, a bottom portion attached thereto, and a top portion attached to the at least one side portion, an opening mechanism for selective opening of a lid over an aperture, a first compartment located within the container and in fluid connection with the aperture, and at least one secondary compartment each having a top portion and a bottom portion located on the top portion of the container, wherein the at least one secondary compartment is external and adjacent to the first compartment; wherein pressure on the top portion of the at least one secondary compartment releases an ingredient from the at least one secondary compartment in the first compartment within the container.

The invention discloses a preparation method of a tea leaf extract rich in tea aroma components, tea polyphenols and caffeine. The method comprises the following steps: firstly, extracting and separating aroma components in tea leaves by using a supercritical CO2 extraction technology, extracting residual residues by using ethanol, separating and enriching by using a normal-phase / reversed-phase column chromatography technology, simultaneously obtaining tea polyphenol and caffeine, and removing other ineffective components, thereby obtaining the tea leaf extract with relatively strong antioxidant, whitening and soothing effects; the color is appropriate, the fragrance is stronger, the stability is better, the activity is better, and the application range is wider; moreover, the whole extraction operation process is simple, and large-scale production is easy, so that the method can be widely applied to products such as cosmetics, shampoo, shower gel, facial cleanser, food and beverage, health care products and the like.

Methylthioninium salt-containing compositions can include methylthioninium chloride (Methylene Blue) in combination with additional compounds that work cooperatively and / or synergistically to treat various conditions. In one example, the methylthioninium salt-containing composition can include methylthioninium chloride, caffeine, and L-theanine. The methylthioninium chloride and the caffeine can be present at a weight ratio from about 1:75 to about 1:4. the methylthioninium chloride and the L-theanine can be present at a weight ratio from about 1 :200 to about 1:10, and the caffeine and the L- theanine can be present at a weight ratio from about 1 :5 to about 1:1.

The invention discloses a method for increasing caffeine content and crude fat content in coffee extract liquor through combination of subcritical water extraction and ethanol. The method comprises the following steps: mixing coffee bean powder with an ethanol water solution, sequentially carrying out programmed heating, staged pressure and temperature control subcritical water extraction, cooling, carrying out solid-liquid separation, and carrying out reduced pressure distillation on filtrate to recover ethanol, thereby finally obtaining the coffee extract. Through ethanol concentration regulation and control in combination with staged temperature control, the content of crude fat is increased to be greater than or equal to 12mg / g while the content of caffeine is greater than or equal to 18mg / g. According to the method, the defect of low crude fat content in traditional subcritical extraction is overcome through the synergistic effect of polarity adjustment of ethanol and subcritical water, and efficient enrichment of two components is realized.

The invention belongs to the technical field of cosmetics, and particularly discloses a cosmetic composition and eye cream for fading dark circles of eyes and a preparation method, the cosmetic composition is prepared from the following raw materials in parts by weight: 0.1-2 parts of Mailong eight-treasure raw powder, 0.1-2 parts of sialic acid, 0.1-5 parts of caffeine, 0.01-1 part of glucosyl hesperidin, 0.01-2 parts of mulberry root bark extract and 0.1-5 parts of botryine. The cosmetic composition provided by the invention can effectively improve the skin microcirculation around eyes, enhance the elasticity of the skin around eyes and reduce hyperpigmentation, so that dark circles around the eyes are obviously faded, and meanwhile, the cosmetic composition also has the advantages of small irritation and high safety; the prepared eye cream is high in stability and small in irritation; meanwhile, the whole process of the eye cream is simple, easy to implement and suitable for industrial production and application.

The invention discloses ultrasonic extraction equipment for caffeine in tea leaves, which comprises a kettle body and a vibration box hoisted at the axis of the inner side of the kettle body, a plurality of uniformly distributed ultrasonic generators are arranged in the vibration box, the bottom of the inner side of the kettle body is fixedly connected with a grinding disc, and an opposite grinding piece is movably arranged at the position, deviating from the axis, above the grinding disc. By combining ultrasonic treatment with mechanical crushing, the crushing efficiency and the crushing degree of tea leaves are improved, the stirring piece can move in the direction of the supporting rod, the tea leaves floating on the liquid level or above can be conveyed downwards in cooperation with the blade design and the rotating motion of the stirring piece, meanwhile, materials at the bottom are overturned upwards to be homogenized, and the crushing efficiency is improved. The movement of the opposite-grinding piece can push tea leaves, avoid material accumulation, prevent repeated grinding of the same batch of tea leaves, and realize functional linkage of grinding operation, material collection and pushing, stirring and directional material conveying under the same driving traction, so that the tea leaves can be uniformly dispersed, and the tea leaves can be fully decomposed under the action of high-frequency sound waves.

To provide a beverage or food in a sealed container which comprises protein hydrolysate, caffeine, and polyphenols and exhibit high long-term preservation stability, and a method for producing the beverage or food in a sealed container.SOLUTION: A beverage or food in a sealed container comprising: a sealed container; and a beverage or food housed in the sealed container, the beverage or food containing caffeine and polyphenols, wherein the beverage or food comprises a protein hydrolysate, and wherein the dissolved oxygen content of the beverage or food at 10°C is 4.0 mg / L or less. The volume of the beverage or food exceeds 99.9 vol.% relative to the volume of the sealed container.SELECTED DRAWING: Figure 1

An object of the present invention is to provide a tea beverage having both a tea-like taste and a fruity aroma while containing tannin and catechin at low concentrations, a method for producing the same, and the like.SOLUTION: A tea beverage having a tannin concentration of 330mg / L or less, a caffeine concentration of 80mg / L or less, and a fruity aroma, wherein the tea beverage satisfies at least one of the following conditions (i) and (ii): (i) a roseoxide concentration of 0.0001 to 5ppm; and (ii) a citronellol concentration of 0.0001 to 10ppm.SELECTED DRAWING: None

Disclosed are compositions for alleviation from adverse physical effects and symptoms of responsible alcohol consumption, and methods for manufacturing and / or administering the compositions. In some aspects, a composition to alleviate discomforting symptoms associated with responsible alcohol consumption includes various formulations of ginger root, L-Theanine, and / or caffeine, which may be derived from particular ingredient sources. In some embodiments, the composition(s) may optionally include salicin. In some embodiments, the composition(s) may optionally include a blend of particular vitamins, electrolytes, and / or salts.

The present invention relates to a functional coffee substitute composition. The coffee substitute food composition comprising a fermented dandelion root extract, a fermented Acanthopanax seed extract, and a fermented soybean extract of the present invention possesses sensory characteristics similar to coffee, and through fermentation, the content of major plant functional components such as isoflavone aglycone, total polyphenols, flavonoids, and saponins increases, L-carnitine is newly synthesized, and since it is a novel coffee substitute food material having antioxidant effects and anti-diabetic activity, it can be utilized as a caffeine-reducing beverage, a beverage that promotes body fat metabolism, an antioxidant-enhanced beverage, and a health functional food.

The invention provides an external composition for improving the sub-health state of people in a high-glucose lifestyle and application of the external composition, and belongs to the technical field of biological agents. The composition provided by the invention is prepared from the following components: caffeine silanol C, a radix sophorae flavescentis extract, a lotus leaf extract, a corn poppy extract, a bitter gourd extract, soy isoflavone, beta-glucan, a tea leaf extract, an apple extract, resveratrol, a pueraria mirifica extract, a propolis extract, an angelica sinensis root extract, a radix ophiopogonis extract and a rhizoma anemarrhenae root extract. The composition is prepared from a fructus gardeniae extract, a Thermus thermophilus fermentation product, oligopeptide-1 and carnosine. The composition provided by the invention can be prepared into an external preparation, is suitable for people in the high-glucose lifestyle, has the technical effects of improving the sub-health states of the people in the high-glucose lifestyle, such as weakness, skin itch, dark skin color, thirst, frequent urination and the like, and improves the life quality of the people in the high-glucose lifestyle.

This invention provides a coffee-flavored chocolate composition with enhanced coffee flavor despite reduced caffeine content, and a method for manufacturing the same. The caffeine content in the chocolate composition is adjusted to 60-750 ppm, and the total content of coffee bean palmitate and caffeoyl palmitate is adjusted to 850-6800 mg / kg.

The invention relates to an oil-soluble coffee essence and a preparation method thereof. The method comprises the steps of coffee hydrolat distillation, edible oil leaching and the like. The prepared coffee essence is pure and natural in fragrance, has oil solubility and is free of alkaloid such as caffeine.

A lip balm formulation for applying to a lip including at least one lipid, at least one surfactant, and at least a first derivative of Cannabaceae, wherein the lip balm formulation includes about 25 wt. % to 60 wt. % of the surfactant based on the total weight of the formulation; wherein the surfactant includes a mixture of mono- and diglycerides and propylene glycol; wherein the surfactant has an HLB of 4; wherein the lip balm formulation includes about 30 wt. % to 60 wt. % of the at least one lipid based on the total weight of the formulation; wherein the at least one lipid includes hydrogenated palm oil; wherein the surfactant minimizes the surface tension of the at least one lipid, and wherein the lip balm formulation includes about 0.1 wt. % to 40 wt. % of the first derivative of Cannabaceae.

The invention discloses a preparation method of cooked wheaten food containing coffee and coffee crisp steamed stuffed bun, and the preparation method of the cooked wheaten food containing coffee mainly comprises the following steps: putting flour, low-sugar yeast, baking powder and salt into a dough mixer, mixing and stirring for 2-3 minutes, then adding coffee mixed liquor, and kneading dough for 5-6 minutes to form first dough, according to the present invention, the Yunnan small-grain coffee and the traditional broken crisp steamed stuffed bun production process are combined, the innovation and the upgrading of the traditional food are achieved, the coffee concentrate is added into the steamed stuffed bun, and the coffee concentrated liquid is added through the slow-release absorption mechanism of the caffeine and the refreshing function, such that the taste of the steamed stuffed bun is improved, and the taste of the steamed stuffed bun is improved. The coffee polyphenol and the carbohydrate are combined to effectively avoid nervous excitation caused by excessive intake, the synergistic effect of the coffee polyphenol and the carbohydrate contributes to blood glucose stabilization, in addition, the technical bottleneck of the existing coffee wheaten food is solved, and the product is endowed with multiple health values, regional culture characteristics and market competitiveness.

The present disclosure relates to a method of providing sustained energy from a beverage comprising one or more stimulants, such as caffeine, comprising (a) administering the beverage comprising one or more stimulants to a consumer; (b) measuring the consumer's plasma concentration of the one or more stimulants over a first time period; (c) measuring the consumer's visual analog scale (VAS) response over a second time period; and (d) increasing or decreasing the amount of the one or more stimulants in the beverage based on the measurements from (b) and (c). The method can further comprise measuring a baseline for each of the consumer's plasma concentration and VAS response prior to (a). The method can also further comprise measuring one or more vital signs, such as heart rate or blood pressure, of the consumer prior to (d) in a third time period.

The disclosure relates to compositions comprising low levels of caffeine (e.g, 25 wt% or less), wherein the composition contains a natural caffeine source in combination with antioxidants, vitamins, electrolytes, and / or amino acids. The disclosed composition, which is made up of natural ingredients, beneficially offers a holistic approach to physical and mental energy. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

The invention discloses low-caffeine nerve stimulation tea wine and a preparation method thereof, the low-caffeine nerve stimulation tea wine is prepared by blending eucommia wood aged tea wine, cherry wood aged tea wine and cherry wood / Hainan dalbergia odorifera wood aged tea wine with different baking degrees, and the mass ratio of geniposidic acid to salidroside to formononetin in the wine body is (2-30): (1-15): 1. The mass ratio of the genkwanin to the alpinia japonica to the sesamol is (0.5-8): (0.15-6): 1, the mass ratio of the isoliquiritigenin to the vitexin to the syringaldehyde is 1: (0.15-5): (4-18), and the total content of the geniposidic acid, the salidroside, the formononetin, the genkwanin, the alpinia japonica, the sesamol, the isoliquiritigenin, the vitexin and the syringaldehyde in the wine is 40-250 mg / 100 mL. By combining and matching the functional components in the wood and the proportion of the functional components, the antagonistic effect on caffeine nerve stimulation in the tea wine is achieved.

The invention discloses a method for gradient extraction of a composite tea pigment through cooperation of salted ginger and directional oxidation and application, and belongs to the technical field of natural product extraction. The method comprises the steps of salting pretreatment, ginger juice enzymolysis, gradient oxidative polymerization (the proportion of theaflavin TF, thearubigin TR and theabrownin is accurately controlled by regulating and controlling temperature, pH and Cu < 2 + > and Fe < 3 + > ions), targeted separation and purification and chitosan-sodium alginate nano embedding (the particle size is 150 + / -20 nm, the Zeta potential is + 32.5 mV, and the encapsulation efficiency is greater than or equal to 75%), and the bioavailability is improved. The free radical scavenging rate is synergistically improved by 2.3 times through the salt and the ginger, the ingredient proportion is controllable through gradient oxidation, and the bioavailability is improved by 3.2 times through nano delivery. The prepared compound tea pigment has caffeine residue of less than or equal to 0.5% and gingerol of more than or equal to 4.5%, has antibacterial activity 4 times higher than that of a single component, is suitable for preparing medicines, health care products and functional foods, can be used for developing medicines for resisting metabolic diseases such as atherosclerosis, diabetes mellitus and tumors, and has the advantages of high yield, function enhancement, wide application and the like.

The present disclosure relates to a method of treatment or prophylaxis of a preterm infant by administering intravenously a therapeutic amount of a composition comprising IGF-1 and IBGBP-3 in combination with a therapy selected from the group comprising: caffeine, fentanyl, fluconazole, gentamicin, insulin, midazolam, morphine, low dose norepinephrine, vancomycin concentrations of 5 mg / ml or less, parenteral nutrition (or a composition for the same use) and combinations thereof.

The invention belongs to the field of daily chemicals. The body care composition comprises the following components in percentage by weight: 0.5%-10% of the lemon-bat hairy-leaf extract, 0.5%-10% of the lemon-bat hairy-leaf extract, 0.5%-10% of the lemon-bat hairy-leaf extract and the balance of water. 0.3%-10% of a lens culinaris seed extract; 0.5%-5% of a centella asiatica extract; 0.3%-1.0% of caffeine; 0.2%-1.0% of sodium salicylate; 0.03% to 0.3% of dipotassium glycyrrhizinate; 0.3% to 1.0% of cyclodextrin; 0.3% to 0.9% of capryloyl glycine; 0.3%-10% of a skin conditioner; 30%-50% of a polyol; and the balance of deionized water. The body care composition containing the lemon pekoe leaf extract is applied to the skin care composition, so that the skin barrier can be repaired, the oil-water balance of the skin can be controlled, the water content of the skin can be increased, excessive grease secretion can be reduced, and the skin can be effectively protected.