459 results about "Acetaldehyde" patented technology

The invention discloses an aldehyde reductase mutant and application thereof in synthesis of a dexmethylphenidate hydrochloride intermediate, and belongs to the field of molecular biology and enzyme engineering. The aldehyde reductase mutant, polynucleotide for coding the mutant, and the recombinant expression vector can express the aldehyde reductase mutant and are used for constructing a recombinant cell or a recombinant strain for expressing the aldehyde reductase mutant. The provided aldehyde reductase mutant can catalyze 2-phenyl-2-((R)-piperidine-2)-acetaldehyde into (R)-2-phenyl-2-((R)-piperidine-2)-1-ethanol, especially improves the stereoselectivity of (R)-2-phenyl-2-((R)-piperidine-2)-1-ethanol, solves the problems of strict conditions, complex reaction and high cost in the existing synthesis method, and has a wide application prospect in the field of synthesis of (R)-2-phenyl-2-((R)-piperidine-2)-1-ethanol. Wide application prospects are realized.

The invention discloses application of a supported heterogeneous catalyst of oxide and copper-manganese spinel in preparation of acetaldehyde by anaerobic dehydrogenation of ethanol, and belongs to the technical field of heterogeneous catalysis for preparation of acetaldehyde and hydrogen by anaerobic dehydrogenation of ethanol. The reaction is carried out in a fixed bed reactor, under the conditions that the reaction atmosphere is nitrogen, the reaction temperature is 280 DEG C and the mass space velocity is 66.1 h <-1 >, the ethanol conversion rate is 72.5%, the acetaldehyde selectivity is 95.0%, and the space time yield of acetaldehyde based on the copper-manganese composite oxide is 43.5 h <-1 >, so that high-selectivity preparation of acetaldehyde and hydrogen under relatively mild conditions is realized; the system has the remarkable advantages of simple catalyst preparation, high catalytic activity under the condition of high mass airspeed, high space-time yield of acetaldehyde, high atom utilization rate of the system, good stability and the like. The CuMnTi-1 catalyst can be stabilized for more than 70 hours, the CuMnTi-1 improves the utilization rate of copper and manganese, improves the catalytic performance, reduces the demand quantity of copper-manganese spinel in the reaction, and reduces the overall cost of catalyst preparation.

The present application provides a kind of for the preparation of C 3+ The application discloses a catalyst for olefin, a preparation method and application, the catalyst is supported by a molecular sieve, and the molecular sieve is MFI molecular sieve or SBA-16 molecular sieve, and the catalyst is loaded with multi-metal, and the multi-metal includes metal tungsten, transition metal and alkali metal. The catalyst is used for providing Lewis acid sites by introducing metal tungsten into MFI molecular sieve or SBA-16 molecular sieve by one-step process, and further selectively introducing transition metal and alkali metal. By selectively coupling hydrogenation-dehydrogenation sites, C-C coupling sites and alkali metal sites in the same multifunctional catalyst, the synergies between the molecular sieve carrier and the multi-metal are realized. The catalyst realizes high-efficiency ethanol-to-C 3+ Olefins conversion in ethanol, with acetaldehyde as the reaction intermediate, and has the advantages of high C 5+ Olefins selectivity.

The invention discloses a copper-based catalyst for preparing acetaldehyde through ethanol dehydrogenation as well as a preparation method and application of the copper-based catalyst. The preparation method comprises the following steps: S1, carrying out alkalization treatment on protic mordenite in a strong alkali solution to increase the number of surface hydroxyl groups of the protic mordenite; and S2, adding the mordenite obtained in the step S1 into a copper salt solution to load copper ions, and then sequentially carrying out low-temperature drying shaping and medium-temperature activation stages to obtain the copper-based catalyst with networked Cu-OH-Si-O bonds on the surface. Through the synergistic effect of alkali liquor regulation and control and staged oxygen roasting, the dispersity and stability of a Cu active center in the catalyst are improved, the acetaldehyde selectivity of the reaction of preparing acetaldehyde through ethanol dehydrogenation is also improved, and side reactions are inhibited. Carrying out heat treatment regeneration on the inactivated copper-based catalyst in an oxygen-containing atmosphere; and after regeneration, the networked Cu-OH-Si-O bond on the surface of the copper-based catalyst is reconstructed.

The invention discloses a genetically engineered probiotic composition for expressing ADH (adenosine dihydrogenase) and ALDH (aldehyde dehydrogenase) and application of the genetically engineered probiotic composition in hangover alleviating and liver protection. The genetically engineered probiotic composition (such as EcN.1917-ADH and EcN.1917-ALDH) is constructed by introducing genes of alcohol dehydrogenase (ADH, NCBI (National Center for Biotechnology Information) Gene ID: 855349) and acetaldehyde dehydrogenase (ALDH, NCBI Gene ID: 855206) of saccharomyces cerevisiae into probiotics (such as escherichia coli). The engineering bacterium shows remarkable ethanol, acetaldehyde and endurance capacity in an in-vitro experiment, and the ethanol degradation rate is remarkably higher than that of a wild type strain; a mouse drunkenness model verifies that drunkenness and death caused by drinking can be reduced through pretreatment, drunkenness tolerance time is remarkably prolonged, and movement coordination disorder caused by alcohol can be improved. The strain can effectively promote alcohol metabolism and relieve alcoholic liver injury, and a new candidate strain is provided for development of a hangover-alleviating and liver-protecting viable bacterial preparation.

The invention discloses a carbamoyl-substituted diarylethene derivative as well as a preparation method and application thereof, and the preparation method comprises the following steps: reacting R-substituted 3-bromo-2-hydroxybenzaldehyde with an arylmethyl triphenylphosphonium bromide compound or an aryl acetic acid compound to obtain an intermediate A; then the intermediate A and cuprous cyanide are subjected to a heating reaction in N, N-dimethylformamide and nitrogen atmosphere, and an intermediate B is obtained; and finally, heating the intermediate B, acetaldoxime and indium trichloride in toluene for reaction to obtain the carbamoyl-substituted diarylethene derivative. The carbamoyl-substituted diarylethene derivative disclosed by the invention has a remarkable effect in an in-vitro anti-tumor activity test, particularly has excellent anti-proliferation ability to human BRCA mutant tumor cells, and can be used for preparing medicines for treating PARP-1 activity abnormity related diseases. The synthesis route is simple, the cost is low, and large-scale implementation is facilitated.

The invention belongs to the field of chemical detection, and particularly relates to a method for detecting ethylene oxide, 2-chloroethanol and acetaldehyde in a frozen beverage by solid-phase microextraction gas chromatography-mass spectrometry. The invention relates to a method for detecting ethylene oxide, 2-chloroethanol and acetaldehyde in a frozen beverage by solid-phase microextraction gas chromatography-mass spectrometry, which comprises the following steps: S.1) taking a frozen beverage sample to be detected, homogenizing and uniformly mixing; s.2) weighing a certain amount of sample, and adding sodium chloride and hydrochloric acid; s.3) determining the sample by adopting a solid-phase microextraction gas chromatography-mass spectrometry method; and S.4) quantitatively analyzing the contents of ethylene oxide, 2-chloroethanol and acetaldehyde in the frozen drink sample to be detected by adopting an external standard method. According to the method disclosed by the invention, the derivatization reaction and the solid-phase microextraction process are combined into one, and the difficulties of complicated pretreatment, long time consumption, low accuracy, unstable result, high detection limit and the like in the traditional analysis technology are overcome. Meanwhile, the precision of a detection result is high, the influence of a complex matrix is removed, and the reproducibility is good.

Disclosed herein is a method for converting ethanol to 1,3-butadiene, wherein the method utilizes H2 produced during a first step of the method for subsequent conversions involved in the method. In particular aspects, H2 produced from converting ethanol to acetaldehyde is used to promote the conversion of the acetaldehyde to 1,3-butadiene. The H2 promotes enhanced catalyst stability, as well as enhanced selectivity and yields of the 1,3-butadiene product. In particular aspects, the method comprises two steps to produce the 1,3-butadiene from the ethanol and H2 produced from a first step facilitates enhanced selectivities and yields for the second step.

A Levodopa-selective sensor is provided. A continuous levodopa monitor is also provided. The levodopa sensor includes a sensor area having a working electrode with a levodopa-selective chemistry configured for at least partial implantation in a host. The sensor also includes at least one membrane adjacent the levodopa-selective chemistry. The at least one membrane includes an enzyme domain that at least one enzyme selected from a tyrosinase; a mutated tyrosinase with specificity towards I-3,4-dihydroxyphenylalanine; a dihydroxyphenylalanine 4,5-dioxygenase; a mutated dihydroxyphenylalanine 4,5-dioxygenase with specificity towards I-3,4-dihydroxyphenylalanine; and combinations thereof; a synthase enzyme with specificity towards I-3,4-dihydroxyphenylalanine; a mutated synthase enzyme with specificity towards I-3,4-dihydroxyphenylalanine; a 3,4-dihydroxyphenyl-acetaldehyde synthase; a mutated 3,4- dihydroxyphenyl-acetaldehyde synthase with specificity towards I-3,4-dihydroxyphenylalanine; a dioxygenase enzyme with specificity towards I-3,4-dihydroxyphenylalanine; and a mutated dioxygenase enzyme with specificity towards I-3,4-dihydroxyphenylalanine.

The invention relates to genetic engineering combined lactobacillus salivarius and application of the genetic engineering combined lactobacillus salivarius. The strain is classified and named as combined lactobacillus salivarius CTMT2, and the preservation number of the strain is CCTCC (China Center for Type Culture Collection) M 2025547. After an NIAAA model is injected into the stomach of an alcoholic liver mouse, the acetaldehyde level of the liver of the mouse is obviously reduced, and the alcoholic fatty liver symptom of the mouse is obviously relieved; after long-term intragastric administration of a high-glucose and high-fat modeling mouse, the acetaldehyde level in excrement of the mouse can be obviously reduced, the progress of liver fibrosis is improved, and good application prospects are achieved.

This application discloses an acetaldehyde recovery device and method in the production of 1,3-butanediol, belonging to the field of fine chemicals. The device includes: a feed pump, a preheater, a distillation column, a falling film reboiler, a bottom circulating pump, a bottom cooler, a top primary condenser, a reflux ratio distributor, a top secondary condenser, a top product tank, a top transfer tank, a bottom product tank, a bottom transfer tank, a vacuum condenser, a vacuum pump inlet separator, a high vacuum unit, and a vacuum pump outlet separator. The horizontal condenser is directly installed at the top of the distillation column, giving it advantages such as simple structure, convenient operation, low pipeline loss, and high vacuum. A method for acetaldehyde recovery in the production of 1,3-butanediol using this device is also disclosed. Compared to existing technologies, this invention uses falling film evaporation combined with vacuum deep cooling, which avoids the thermal decomposition of 3-hydroxybutyraldehyde and achieves low-temperature, high-efficiency acetaldehyde recovery. It is suitable for continuous production.

The application provides a system and method for integrated acetaldehyde distillation and recovery, which comprises a vertically arranged main tower, the main tower is sequentially divided into a distillation section, a catalytic reaction section, a stripping section and a stripping section from top to bottom, the top of the distillation section is provided with a self-adaptive distributor and a tower top pressure controller, the catalytic reaction section comprises catalytic filler plates and a transverse liquid redistributor, and the catalytic filler plates are loaded with catalysts. The four sections of stripping, stripping, catalytic reaction and distillation are integrated in the vertical main tower, the intermediate cooling and conveying equipment are cancelled, and the investment and energy consumption are significantly reduced. The catalytic reaction section adopts the corrugated filler loaded with catalysts and cooperates with the transverse liquid redistributor, so that the liquid forms thin layer flow, the reaction residence time is effectively prolonged, and the hydrolysis decomposition rate of 2-methyl-1,3-dioxolane (MD) and the acetaldehyde recovery rate are improved.

The invention discloses a brewing process for improving the grain steaming efficiency by boiling grains at constant high temperature, and belongs to the technical field of white spirit brewing. The process comprises the steps of sorghum cleaning, constant-temperature grain cooking, spreading for cooling, adding yeast, fermenting in a barrel and distilling, and the core is that constant-temperature hot water of 60 + / -1 DEG C is adopted, three-stage cooking is matched with two-time deep turning under the micro-pressure environment of 0.02-0.05 MPa according to the water-grain ratio of (2.3-2.7): 1, the core penetration rate of cooked grains is larger than or equal to 95%, and the pretreatment time is shortened to 30 minutes; by combining three-stage temperature-controlled fermentation, acetaldehyde is reduced to 0.48 g / L, fusel oil is reduced to 1.12 g / L, the flavor and efficiency of the raw wine are improved, and the dual effects of energy conservation and quality improvement are achieved.

The invention relates to polyfurandicarboxylic acid glycol ester resin as well as a preparation method and application thereof, and belongs to the technical field of organic high-molecular compounds. The preparation method of the polyethylene furandicarboxylate resin provided by the invention comprises the following steps: S1, mixing 2, 5-furandicarboxylic acid, ethylene glycol, a catalyst and an inhibitor, and carrying out esterification reaction to obtain an ester; and S2, carrying out low-pressure condensation polymerization on the ester obtained in the step S1 to obtain the polyethylene furandicarboxylate resin, the inhibitor is ethylene carbonate; according to the GB / T14571.2-2018 standard, based on the chromatographic purity of the ethylene glycol, the chromatographic peak area of the inhibitor in the mixture of the ethylene glycol and the inhibitor is 0.05%-0.6% of the sum of the chromatographic peak area of the inhibitor and the chromatographic peak area of the ethylene glycol. The preparation method can effectively reduce the content of acetaldehyde in the polyethylene furandicarboxylate resin.

The invention discloses Leishan fish sauce sour essence as well as a preparation method and application thereof. The leishan fish sauce acid essence is prepared from ethyl acetate, absolute ethyl alcohol, ethyl isovalerate, ethyl hexanoate, isoamyl alcohol, furfuryl alcohol, ethyl lactate, ethyl caprylate, acetic acid, diethyl succinate, methyl salicylate, ethyl benzoate, ethyl laurate, hexanoic acid, phenethyl alcohol, 4-methyl guaiacol, ethyl myristate, ethyl palmitate, ethyl oleate, capsicum oleoresin, ethyl phenylacetate and ginger oil. And lactic acid, glycerol triacetate, ocimene, ethyl isovalerate, ethyl butyrate, anethole and phenylacetaldehyde. The Leishan fish sauce sour essence disclosed by the invention is soft and harmonious in overall fragrance, natural and vivid, still has stable flavor characteristics at high temperature, can make up the problem of flavor deficiency in sour soup products, realizes accurate reproduction and controllable release of composite fragrance, improves the standardization level of products, and effectively improves the preference degree of consumers.

This invention discloses the application of an amino-functionalized hypercrosslinked ionic polymer in the adsorption of polar small-molecule VOCs, relating to the field of high-efficiency adsorption technology for polar small-molecule VOCs. The method involves mixing a substrate, a crosslinking agent, a functional monomer, a catalyst, and a solvent, and then reacting them in a nitrogen atmosphere to obtain the amino-functionalized hypercrosslinked ionic polymer. This amino-functionalized hypercrosslinked ionic polymer adsorbs polar molecules such as methanol, acetaldehyde, or acetone through abundant adsorption sites. This invention utilizes the strong polarity and electrophilic properties of polar small-molecule VOCs to design and prepare the amino-functionalized hypercrosslinked ionic polymer as an adsorbent. This adsorbent is prepared through a Friedel-Crafts alkylation reaction between the substrate, the crosslinking agent, and the functional monomer. It possesses abundant functional sites, a unique ionic environment, and a microporous structure, exhibiting a high adsorption capacity for polar small-molecule VOCs, far exceeding that of conventional adsorbents such as commercially available activated carbon and molecular sieves.

The invention relates to pediococcus acidilactici b1274 and application thereof, and belongs to the technical field of beneficial bacterium application. The pediococcus acidilactici b1274 is preserved in the China Center for Type Culture Collection on September 24, 2025, the preservation number is CCTCC M 20252094, and the pediococcus acidilactici b1274 is obtained by separation and purification from distiller's yeast. The pediococcus acidilactici can be used for preparing microbial enhanced distiller's yeast, is applied to brewing of fen-flavor liquor, and can improve the content of ethyl acetate, ethyl lactate and total acid in the liquor and reduce the content of acetaldehyde at the same time. Compared with a production control group, the content of ethyl acetate is increased by 50.0%, the content of ethyl lactate is increased by 8.1%, the total acid is increased by 46.4%, the acetaldehyde is reduced by 48.4%, the brewed white spirit shows the style of faint scent, purity, mellowness, fullness, softness, sweetness, freshness, long aftertaste and mellow and prominent acid ester taste, and a safe and reliable functional strain and a technical scheme are provided for improving the quality of the fen-flavor white spirit.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus paracasei BL19 and application thereof to preparation of products with functions of dispelling effects of alcohol and protecting liver. The lactobacillus paracasei BL19 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the lactobacillus paracasei BL19 is CGMCC No.34368. The lactobacillus paracasei BL19 is named as Lactobacillus paracasei BL19. The lactobacillus paracasei BL19 provided by the invention has relatively strong alcohol tolerance, alcohol degradation capability and relatively high activity of promoting alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH); the lactobacillus paracasei BL19 has the advantages that the lactobacillus paracasei BL19 has good anti-alcohol and anti-liver effects and strong capacity of protecting alcoholic injury liver cells, so that the anti-alcohol and anti-liver effects can be comprehensively achieved from multiple dimensions, and in addition, the lactobacillus paracasei BL19 has strong acid resistance and bile salt resistance, also has strong tolerance to simulated gastrointestinal fluid and has important application value in the fields of anti-alcohol and anti-liver products and the like.

A mosquito repellent composition and a preparation method therefor and a use thereof, and a product having the composition, relating to the technical field of mosquito repelling. The mosquito repellent composition comprises in percentage by weight: 0.1-40% of a mosquito repellent active ingredient, 1-10% of an emulsifier, 3-8% of an antifreeze agent, 0.1-3% of a thickener, 0.1-2% of a defoamer, and the balance being water, or 0.1-40% of a mosquito repellent active ingredient, 1-10% of an emulsifier, 1-10% of a capsule wall material, 0.1-0.5% of a pH regulator, 3-8% of an antifreeze agent, 0.1-3% of a thickener, 0.1-2% of a defoamer, and the balance being water, wherein the mosquito repellent active ingredient comprises α-ethylidene-phenylacetaldehyde, or a tautomer or cis-trans isomer thereof. Compared with an α-ethylidene-phenylacetaldehyde technical material, the mosquito repellent composition has greatly improved thermal storage stability and a longer-lasting mosquito repellent effect. Compared with emulsions in water and capsule suspensions prepared by other formulas, the emulsion stability after thermal storage is greatly improved.

The application relates to the technical field of polymer material processing and molding, and discloses a temperature gradient control method for melting and plasticizing of food packaging PET bottle blanks. The method aims to solve the problems of static temperature control, poor melt homogeneity and weak process adaptability in the traditional plasticizing process. The method comprises the following steps: constructing an axial partition temperature setting model, dividing a solid conveying section, a melting transition section and a melt homogenization section and setting a reference temperature interval; deploying a distributed temperature sensing array to collect temperatures at key positions in real time; establishing a melt thermal state prediction model based on a non-Newtonian fluid heat conduction equation; dynamically regulating and controlling heating and cooling through a PID compound algorithm to realize closed-loop control of axial gradient and radial uniformity; and combining a process database to perform adaptive parameter correction. The application can significantly improve temperature control precision and melt homogeneity, enhance adaptability to raw material changes and high-speed production, effectively reduce bottle blank internal stress, wall thickness deviation and acetaldehyde content, and guarantee product quality and food safety.

The application belongs to the technical field of catalytic dehydrogenation, and particularly relates to a catalyst for preparing acetaldehyde by dehydrogenating ethanol, and preparation and application of the catalyst. The catalyst uses silicon dioxide as a carrier, Cu as an active component, and a small amount of Ni and Zn as additives. The loading amount of the active component Cu in the catalyst is 2.0-25wt%, and the loading amounts of the additives Ni and Zn in the catalyst are 0.02wt%-2.0wt% and 0.01wt%-1.0wt% respectively. The catalyst has a simple preparation process, only a small amount of ammonia water is used as a precipitant, the catalyst avoids the need for excessive ammonia water and a complex ammonia evaporation process in the ammonia evaporation method, and the catalyst does not use organic silicon compared with the gel method, and the catalyst has low production cost. The catalyst has high catalytic activity, good acetaldehyde selectivity, and good long-period operation stability in the reaction of preparing acetaldehyde by dehydrogenating ethanol.

Provided is a process for producing acrylic acid, wherein the process comprises a first step and a second step in which a first absorbent is added to a reaction product of a bio-material and cooled to separate a first low-boiling-point material including acetaldehyde (ACHO) and a first high-boiling-point material including acrylic acid (AA). The process is capable of producing high-purity acrylic acid at high yield, and acetaldehyde is produced as by-product along with the reaction product of the bio-material. The process includes separating the acetaldehyde produced as by-product into a high-purity product at high yield.

The application discloses a brewing method for improving the quality of a light-flavor type base liquor by using medicinal and edible Chinese herbal medicines, four kinds of medicinal and edible Chinese herbal medicines, namely, clove, mulberry leaf, lophatherum gracile and osmanthus, are adopted, and the suitable adding link and adding proportion of the medicinal and edible Chinese herbal medicines in the brewing process are determined. Compared with the traditional brewing process, the content of fusel oil (defect component) in the base liquor produced by the application is reduced by 13.89%, the content of ethyl acetate (important flavor component) is increased by 71.14%, the content of beta-damascenone is increased by 240.36%, and the contents of defect components such as acetaldehyde, methanol, n-propanol and fusel oil are all significantly reduced.

The invention belongs to the field of photocatalysis, and particularly discloses a perovskite composite photocatalyst for photocatalytic ethanol dehydrogenation and application. The composite photocatalyst takes a CdS nanorod as a carrier, a Cs2AgBiBr6 double perovskite active component formed by CsBr, AgBr and BiBr3 precursors is loaded on the surface of the CdS nanorod through a vacuum in-situ growth method, and a Pt, Rh or Ni metal cocatalyst can be further loaded. The method comprises the following steps: dispersing a CdS nanorod and a perovskite precursor in a mixed organic solvent, carrying out vacuum freezing-air exhaust circulation treatment, and removing the solvent under a heating condition to prepare the composite photocatalyst. When the photocatalyst is used for an ethanol photocatalytic dehydrogenation reaction under an anaerobic condition, hydrogen, acetaldehyde and acetal can be efficiently generated under the irradiation of visible light. According to the method, the photo-generated charge separation efficiency and the reaction stability are remarkably improved, and a new way is provided for ethanol high-valued conversion.

The application provides a lactococcus lactis, a compound dairy product fermenting agent and application thereof, the lactococcus lactis has the functions of sweetening and flavoring, and is classified and named as lactococcus lactis Lactococcus lactis The strain has significant sweetening and flavoring characteristics, exhibits strong fructo-oligosaccharide (FOS) and acetaldehyde generation capacity in the fermentation process, can provide endogenous sweet taste and aroma flavor substances for fermented milk, and significantly improves the taste and flavor of the fermented milk.The lactococcus lactis C15 is compounded with lactobacillus casei AU9077 and lactobacillus rhamnosus AU9260 to obtain a compound dairy product fermenting agent, which has a significant synergistic effect in releasing fructo-oligosaccharide, continuously provides stable endogenous sweetening effect for fermented milk, improves the quality of dairy products, and meets the needs of consumers for healthy and flavored dairy products.

The application discloses a kind of tetrameric acetaldehyde granules and preparation method thereof, which have both attractivity and waterproofness.The tetrameric acetaldehyde is mixed with fillers, filler attractants and binders after adding water, and then granulated.The prepared granules are coated with a coating agent containing polyethylene glycol monomethacrylate or sodium lignosulfonate, and then sprayed, coated and dried to obtain the tetrameric acetaldehyde granules with both attractivity and waterproofness.The test results show that the tetrameric acetaldehyde granules have strong attractivity to golden apple snails, and the tetrameric acetaldehyde in the granules will not be quickly precipitated into water after being contacted with water, so that the tetrameric acetaldehyde can be used for long-term to kill golden apple snails, which is conducive to the efficient prevention and control of golden apple snails.

The invention relates to the technical field of gene engineering, in particular to an ethanol response type gene engineering alcohol-dissolving probiotic as well as a construction method and application thereof. According to the probiotics provided by the invention, an ethanol-responsive regulation mechanism is innovatively introduced, so that the strain can specifically induce high-efficiency expression of human ethanol dehydrogenase 1B (hADH1B) and human acetaldehyde dehydrogenase 2 (hALDH2) when sensing the existence of ethanol in vivo, thereby realizing on-demand and high-efficiency decomposition of ethanol and toxic metabolite acetaldehyde thereof. Compared with continuous expression of traditional engineering bacteria, the intelligent regulation and control mode can better simulate the natural metabolic rhythm of a human body, solves the problem of bacterial metabolism, reduces the metabolic pressure of thalli while improving the hangover alleviating efficiency, and is expected to achieve a better hangover alleviating effect and higher biological safety.

The present invention relates to a yeast cell, in particular a recombinant yeast cell, the cell lacking enzymatic activity needed for the NADH-dependent glycerol synthesis or the cell having a reduced enzymatic activity with respect to the NADH-dependent glycerol synthesis compared to its corresponding wild-type yeast cell, the cell comprising one or more heterologous nucleic acid sequences encoding an NAD+-dependent acetylating acetaldehyde dehydrogenase (EC 1.2.1.10) activity. The invention further relates to the use of a cell according to the invention in the preparation of ethanol.

The invention provides an electroplating solution containing a novel additive and application of the electroplating solution in copper electroplating. The pyridine-2-acetaldehyde oxime methyl iodide is used as a novel copper electroplating additive (leveling agent) for the copper electroplating process, the cost is low, safety and no pollution are achieved, and the novel additive stably exists in the electroplating liquid. The novel additive is applied to the electrocoppering process, compact filling from bottom to top can be achieved, the surface of a plating layer is bright and flat, different adsorption behaviors of the additive can be regulated and controlled by regulating and controlling distribution of current density at interfaces of the inner surface and the outer surface of a micropore, and therefore the additive can be widely applied to high-density interconnection of electronic devices and can be applied to electrocoppering. And high-quality and high-stability signal transmission is satisfied.

The application relates to a preparation method of polydopamine-mediated nitrogen-carbon co-doped titanium dioxide hollow microspheres and application thereof, and the specific steps are as follows: ammonia is dispersed into a prepared dilute ethanol solution to obtain solution A; a dopamine solution is added into the solution A to stir to form a suspension B, and polydopamine microspheres PDA are obtained through washing, collecting and drying; a titanium source is added into the PDA dispersion to stir to form a suspension C; the suspension C is mixed with ethanol and then added into deionized water to form a suspension D, and core-shell structure titanium dioxide microspheres PDA@TiO2 are obtained through washing, collecting and drying. The PDA@TiO2 is placed in a muffle furnace to be calcined to obtain nitrogen-carbon co-doped titanium dioxide hollow microspheres. The titanium dioxide hollow microspheres prepared by the method have the characteristics of an ultrathin shell, nitrogen-carbon co-doping, porosity and rich oxygen vacancies, and the removal efficiency of flowing gaseous acetaldehyde under visible light reaches 90%.