834 results about "Acetaldehyde" patented technology

The present invention relates to a recombinant yeast with high squalene production, a construction method and a use thereof, wherein the recombinant yeast is a saccharomyces cerevisiae that expresses or overexpresses HMGR gene, ADA gene, LEU2 gene, MVA pathway gene and squalene synthase gene ERG9. The present invention integrates acetaldehyde dehydrogenase gene ADA and HMG-CoA reductase gene tHMGR in multiple copies in saccharomyces cerevisiae, integrates the screened high-activity phosphoketolase gene PK and phosphotransacetylase gene PTA, weakens epoxysqualene synthesis, strengthens the mevalonate pathway, overexpresses yeast endogenous squalene synthase gene, etc. to obtain a recombinant yeast with high squalene production, so that the production in the shake flask stage of the production process exceeds 5g / L, and the production in the fed batch fermentation stage exceeds 50g / L, breaking through the current bottleneck of microbial synthesis of squalene production, and is suitable for practical promotion and application.

The invention relates to Pediococcus pentosaceus PP90 for preventing and treating alcoholic nerve injury and application of the Pediococcus pentosaceus PP90, the Pediococcus pentosaceus PP90 is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.32034. The Pediococcus pentosaceus PP90 can be used for preventing and treating alcoholic nerve injury. The fermentation product of the pediococcus pentosaceus PP90 can degrade the alcoholic strength of alcohol, can generate ethanol dehydrogenase and acetaldehyde dehydrogenase, can improve the activity of nerve cells, can regulate the expression of cytokines, can inhibit the activation of astrocytes, can regulate the expression of brain-derived neurotrophic factors, and can inhibit the growth of the brain-derived neurotrophic factors. The compound can improve the disordered neurotransmitter level, and can be used for preparing products for preventing or improving alcoholic nerve injury.

The invention relates to the technical field of starch processing, in particular to a preparation method and application of modified starch, and the modified starch is prepared from the following raw materials in parts by mass: 15-30 parts of pre-modified starch A and 55-70 parts of pre-modified starch B; the pre-modified starch A is prepared from pretreated starch A, acetic anhydride and acetaldehyde dehydrogenase; the pretreated starch A is frozen ball-milled starch; the pre-modified starch B is prepared from pre-treated starch B and octenyl succinic anhydride; the pretreated starch B is step-by-step toughened starch; the step-by-step toughening treatment comprises the following steps: performing low-temperature sealing treatment on starch, performing short-time ultrasonic treatment, performing heating reaction, performing secondary ultrasonic treatment, performing high-temperature treatment, and performing secondary ultrasonic treatment; the pre-modified starch A and the pre-modified starch B are mixed according to a specific proportion, and the modified starch which is high in solubility and freeze-thaw stability and can be widely applied to the fields of food, papermaking, spinning and medicine is obtained.

The invention discloses a medicinal and edible anti-alcoholism composition and a preparation method thereof, and relates to the crossing field of biotechnology and food and medicine, the composition comprises the following components: dried orange peel powder, vitamin C, glutathione, phellinus igniarius extract, polygonatum sibiricum extract, oriental wormwood extract, isatis root extract, schisandra chinensis extract, ginseng powder, lucid ganoderma extract and licorice extract. Silymarin, puerarin, white tomato powder, watermelon powder, fucoidin, tomato powder, mung bean powder, celery powder, turmeric powder, hawthorn fruit powder, honey powder, corn peptide, soybean peptide powder, xanthan gum and stevioside are added. The composition provided by the invention has the effect of increasing the content of ethanol dehydrogenase and acetaldehyde dehydrogenase in blood after drinking, and has the capability of promoting alcohol metabolism.

The invention relates to the field of food and health care products, and discloses a composition for dispelling effects of alcohol and protecting liver, which comprises 20-100 parts of ampelopsis grossedentata leaf extract; 50 to 200 parts of a radix puerariae extract; 10-50 parts of a semen hoveniae extract; 10-50 parts of a turmeric extract; 10 to 100 parts of a yeast extract; 5-50 parts of a licorice extract; and 5 to 20 parts of pyrroloquinoline quinone disodium salt. The ampelopsis grossedentata leaf extract, the kudzuvine root extract and the hovenia dulcis thunb extract are utilized, alcohol decomposition is promoted, the blood ethanol concentration is reduced, and drunkenness symptoms are relieved. Puerarin improves activity of liver metabolic enzymes, accelerates discharge of ethanol and acetaldehyde, and reduces liver damage. The anti-oxidation effects of dihydromyricetin and PQQ can eliminate alcohol metabolism free radicals and protect liver cells. The components such as puerarin, hovenia dulcis thunb, curcumin and glycyrrhizic acid jointly promote liver cell regeneration, inflammation and oxidative damage are reduced, the levels of ALT and AST in serum are reduced, and liver health is maintained.

The invention discloses a refining device and method for a polymerization product and application. The refining device comprises an aldehyde removal tower, a dehydration tower, a water separation tank, a light component removal tower, a byproduct tower and a product tower. According to the present invention, the reaction product obtained through the ethylene glycol dehydration condensation reaction contains water, acetaldehyde, diethylene glycol, 1, 4-dioxane, 2-methyldioxocyclopentane and other components, and has characteristics of complex components and coexistence of multiple azeotropic pairs, and the invention provides the sequential rectification method by introducing the azeotropic breaking component according to the composition, therefore, a diethylene glycol product with high purity and byproducts of acetaldehyde and 1, 4-dioxane are separated, the process is continuous and easy to operate, and the method has industrial feasibility.

The invention discloses a nitrogen-doped carbon dot material with a high emulsification level and a preparation method thereof, and belongs to the technical field of two-dimensional interface materials. The method comprises the following steps: firstly, adding a NaOH aqueous solution into an acetaldehyde aqueous solution, then adding hydrochloric acid to adjust the pH value of the solution to be neutral, stirring for reaction, then centrifuging to retain precipitate, extracting with liquid nitrogen, and freeze-drying to obtain a carbon dot material; and adding the carbon dot material into a system of potassium methoxide and a nitrogen source, carrying out heating reaction, carrying out centrifugation, retaining the precipitate, drying, and preparing the nitrogen-doped carbon dot material with a high emulsification level by controlling the reaction time, regulating the acid amount and changing the nitrogen source. A large amount of nanoscale nitrogen-doped carbon dot material emulsifiers with an amphiphilic emulsification effect can be rapidly synthesized under mild reaction conditions, the obtained nitrogen-doped carbon dot material is uniform in size and high in dispersity, the emulsification requirements under different oil phase conditions can be met, the preparation process is simple, dialysis and centrifugation are not needed in industrial production, and the method is suitable for industrial production. And the nitrogen-doped carbon dot material with a high emulsification level can be prepared only through centrifugation and drying.

The invention discloses an aldehyde reductase mutant and application thereof in synthesis of a dexmethylphenidate hydrochloride intermediate, and belongs to the field of molecular biology and enzyme engineering. The aldehyde reductase mutant, polynucleotide for coding the mutant, and the recombinant expression vector can express the aldehyde reductase mutant and are used for constructing a recombinant cell or a recombinant strain for expressing the aldehyde reductase mutant. The provided aldehyde reductase mutant can catalyze 2-phenyl-2-((R)-piperidine-2)-acetaldehyde into (R)-2-phenyl-2-((R)-piperidine-2)-1-ethanol, especially improves the stereoselectivity of (R)-2-phenyl-2-((R)-piperidine-2)-1-ethanol, solves the problems of strict conditions, complex reaction and high cost in the existing synthesis method, and has a wide application prospect in the field of synthesis of (R)-2-phenyl-2-((R)-piperidine-2)-1-ethanol. Wide application prospects are realized.

The invention relates to a plant lactobacillus with effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus. The plant lactobacillus is a plant lactobacillus BGI-J9 strain, and the preservation number of the plant lactobacillus is CCTCC NO: M 20242630. The invention further discloses a preparation method of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness. The strain has excellent tolerance to gastric acid, intestinal juice and cholate in a gastrointestinal tract system, can survive in the gastrointestinal tract, and provides a basis for continuously playing a probiotic effect; the compound has excellent inhibition capability on common intestinal pathogens; free radicals can be removed, and oxidative damage to the body is reduced; good alcohol metabolism enzyme synthesis capability and alcohol metabolism promoting potential are realized; the strain also has an excellent improvement effect on alcohol-damaged mice, specifically, the metabolism of ethanol and acetaldehyde in a body is accelerated, the occurrence time of drunkenness is obviously delayed, and the sobering time is shortened; intestinal injury and systemic inflammation caused by alcohol are improved; liver oxidative stress caused by alcohol is improved, and the occurrence and development process of alcoholic fatty liver is delayed; and cognitive function impairment caused by alcohol is improved.

The invention relates to pediococcus acidilactici PA27 capable of degrading alcohol and improving alcoholic nerve injury and application of the pediococcus acidilactici PA27, the pediococcus acidilactici PA27 is preserved in China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.31922. The pediococcus acidilactici PA27 can degrade alcohol and improve alcoholic nerve injury. The pediococcus acidilactici PA27 separated and screened by the invention can grow and propagate in an alcohol-containing culture medium, can degrade alcohol and can generate ethanol dehydrogenase and acetaldehyde dehydrogenase; the polypeptide can be used for constructing a blood-brain barrier and reducing the damage of alcohol to central nervous cells; the traditional Chinese medicine composition can reduce the expression of inflammatory cytokines TNF-alpha, inhibit the activation of astrocytes, promote the expression of brain-derived neurotrophic factors BDNF, regulate the release of alcohol-induced astrocyte neurotransmitters and improve alcoholic nerve injury.

The invention relates to the field of medicines, and particularly discloses application of mogroside V in preparation of a medicine for dispelling the effects of alcohol and protecting the liver, experiments prove that the anti-alcohol effect of the mogroside V is obviously superior to that of a mogroside crude extract, and in one embodiment, the mogroside V can increase protein expression of ethanol dehydrogenase and acetaldehyde dehydrogenase in the liver of a mouse at the same time. In one embodiment, the mogroside V can prolong the drunkenness tolerance time of a mouse and shorten the drunkenness time of the mouse. In another embodiment, the mogroside V can relieve liver inflammation caused by alcohol. In a further embodiment, the mogroside V can greatly relieve liver fat deposition caused by alcohol. Therefore, the mogroside V can be developed into a brand new product for dispelling the effects of alcohol and protecting the liver, and has a huge application prospect.

The invention provides frozen broccoli with improved broccoli flavor. In the frozen broccoli, the ratio of the peak area of phenylacetaldehyde to the peak area of 1-octylene-3-ketone, which is obtained by gas chromatography-mass spectrometry, is adjusted within the range of 2.5-5.5.

The invention discloses a composition for dispelling effects of alcohol and protecting liver and application thereof, and belongs to the technical field of biology. The composition comprises the following components in percentage by mass: 0.5-2% of probiotics, 6-20% of beta-glucan, 10-20% of corn peptide and 50-80% of medicinal and edible substances, and the probiotics are mixed bacterial powder prepared by freeze-drying bacillus coagulans BCN019 and lactobacillus salivarius JYLS-372 and then mixing the bacillus coagulans BCN019 and the lactobacillus salivarius JYLS-372 according to a mass ratio of (0.1-1): 1; the medicinal and edible substance is obtained by mixing a hovenia dulcis thunb extract, a kudzuvine root extract and a turmeric extract in a mass ratio of (0.1-1): (0.1-1): (0.1-1). The composition can relieve headache, dizziness and other uncomfortable symptoms caused by drinking; the contents of ethanol and acetaldehyde in the body can be obviously reduced, and the metabolism of the liver is relieved; meanwhile, by improving the intestinal microecology, gastrointestinal discomfort symptoms caused by excessive drinking can be effectively reduced, and hangover reaction is relieved.

The invention provides an alpha, beta unsubstituted 1, 4-ketoaldehyde compound and a metal-free photocatalytic aqueous solution acetaldehyde alpha-position selective single alkylation reaction preparation method and application thereof, a photosensitizer and alpha bromine / chloro aryl ethyl ketone are mixed in an organic solvent, then TEEDA, nBu4NI and an acetaldehyde aqueous solution are sequentially added, white light irradiation stirring reaction, separation and purification are performed, and the alpha, beta unsubstituted 1, 4-ketoaldehyde compound is obtained. Compared with the prior art, the method has the advantages that by improving the light source, the reaction can be amplified to the gram scale level, the yield of the corresponding alpha and beta unsubstituted 1, 4-ketoaldehyde product is not obviously reduced, and a basis is provided for the industrialization process of the reaction. The reaction disclosed by the invention has the characteristics of wide substrate range, high functional group tolerance, simplicity in operation, mild reaction conditions and the like. Moreover, the product disclosed by the invention can be subjected to reductive amination with cyclic secondary amine to obtain a series of gamma-aminoketones with biological activity, which shows that the reaction has potential synthesis application value in the field of pharmaceuticals.

A synthesis method of aminoacetaldehyde dimethyl acetal relates to the technical field of fine chemical engineering, and comprises the following steps: chlorination reaction: uniformly mixing and stirring vinyl acetate and methanol; introducing chlorine gas and then carrying out heat preservation reaction; then adding a neutralizer to carry out neutralization reaction; after the neutralization reaction, standing for layering, removing a water phase, and carrying out primary rectification on an organic phase to obtain chloroacetaldehyde dimethyl acetal; ammonolysis reaction: introducing nitrogen and / or inert gas into the obtained chloroacetaldehyde dimethyl acetal for purging; dropwise adding a saturated methanol-ammonia mixed solution for reaction; after the reaction is completed, insoluble ammonium chloride is filtered out, filtrate is introduced into a rectifying tower for secondary rectification, and a finished product of aminoacetaldehyde dimethyl acetal is obtained. Wherein the neutralizer adopts calcium oxide, and the aminoacetaldehyde glycol is prepared by a solvent-free method, so that the generation of wastewater is greatly reduced in the preparation process, and the cost required by wastewater treatment is reduced.

The invention discloses application of gabexate to treatment of alcoholism. More specifically, the present invention provides the use of gabexate or a pharmaceutically acceptable salt thereof, or a metabolite thereof in the preparation of a pharmaceutical composition for the prevention or treatment of alcoholism and / or alcoholic liver disease. The invention also provides application of gabexate or a pharmaceutically acceptable salt thereof, or a metabolite of gabexate in preparation of an acetaldehyde dehydrogenase 2 (ALDH2) agonist. The invention also discloses application of gabexate or pharmaceutically acceptable salts thereof or metabolites thereof in preparation of health-care food with an auxiliary protection effect on alcoholic liver injury.

The invention relates to a medicinal and edible plant composition and application thereof. The medicinal and edible plant composition is an aqueous extract of the following preparation raw materials: kudzuvine root, hovenia dulcis thunb, chrysanthemum bud, poria cocos and liquorice. According to the invention, five specific medicinal and edible raw materials are reasonably combined to prepare a water extraction product, the product has an excellent anti-oxidation effect, has an activation effect on ethanol dehydrogenase and acetaldehyde dehydrogenase, and has very good potential of dispelling the effects of alcohol and protecting the liver, and all the components are mutually matched and have a synergistic effect on the effects.

The invention discloses application of a supported heterogeneous catalyst of oxide and copper-manganese spinel in preparation of acetaldehyde by anaerobic dehydrogenation of ethanol, and belongs to the technical field of heterogeneous catalysis for preparation of acetaldehyde and hydrogen by anaerobic dehydrogenation of ethanol. The reaction is carried out in a fixed bed reactor, under the conditions that the reaction atmosphere is nitrogen, the reaction temperature is 280 DEG C and the mass space velocity is 66.1 h <-1 >, the ethanol conversion rate is 72.5%, the acetaldehyde selectivity is 95.0%, and the space time yield of acetaldehyde based on the copper-manganese composite oxide is 43.5 h <-1 >, so that high-selectivity preparation of acetaldehyde and hydrogen under relatively mild conditions is realized; the system has the remarkable advantages of simple catalyst preparation, high catalytic activity under the condition of high mass airspeed, high space-time yield of acetaldehyde, high atom utilization rate of the system, good stability and the like. The CuMnTi-1 catalyst can be stabilized for more than 70 hours, the CuMnTi-1 improves the utilization rate of copper and manganese, improves the catalytic performance, reduces the demand quantity of copper-manganese spinel in the reaction, and reduces the overall cost of catalyst preparation.

The invention belongs to the technical field of brewing microbial fermentation, and particularly relates to a new monascus purpureus strain and application thereof. In order to further enrich beneficial microorganisms in a white spirit brewing environment, the invention provides a new Monascus purpureus strain capable of producing protease and hydrolase at high yield, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.41533. The strain is used for preparing mouldy bran, yeast for making hard liquor and strengthened yeast for making hard liquor, and various hydrolases for brewing can be produced at high yield; and various flavor substances such as phenethyl alcohol, isoamyl alcohol and phenylacetaldehyde can be produced under the simulated pit fermentation condition, so that the requirements of brewing of multi-grain Luzhou-flavor liquor are met, a new choice is provided for improving the flavor of liquor in liquor brewing, and the method has wide application prospects and great application value.

The invention discloses yoghurt oil with fruity flavor and a preparation method of the yoghurt oil, and belongs to the technical field of yoghurt oil processing. The Lactococcus lactis SITRS-0011 provided by the invention can be independently used as a leavening agent, when the Lactococcus lactis SITRS-0011 is used for fermenting yoghurt oil, the titration acidity can reach 83.21 DEG T, the yoghurt oil contains 2, 3-butanedione (1180 [mu] g / kg), acetoin (2092 [mu] g / kg), lactones (623 [mu] g / kg), 3-methylbutyraldehyde (117 [mu] g / kg), phenethyl alcohol (1863 [mu] g / kg), phenylacetaldehyde (336 [mu] g / kg) and other substances, and the Lactococcus lactis SITRS-0011 is rich in milk flavor, has flower fragrance and nut flavor, is unique in flavor, and can be used for preparing the and the overall sensory score is high.

To provide a food quality preservative enabling further reduction of acetaldehyde concentration in a food packaging body.SOLUTION: A food quality preservative is used, the preservative comprising at least an ethanol vapor-releasing body, an oxygen absorber, and an aminooxyalkyl group-containing polysiloxane having a structural unit represented by the following general formula (1). [In the formula, R independently represents an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, or a hydroxyl group. The alkyl group may have an amino group (-NH2) at any position. Q independently represents a divalent organic group having 1 to 20 carbon atoms. n represents a real number of 0 to 100].SELECTED DRAWING: None

The invention relates to a preparation and synthesis method of an amino-substituted nitrogen-containing heterocyclic ring, which is carried out by using an ice bath auxiliary device, and is characterized by comprising the following steps: adding p-aminobenzaldehyde into a toluene solution of aminoacetaldehyde dimethyl acetal, heating to reflux to obtain (Z)-N-(4-acetamido-benzylidene)-2, 2-dimethoxyethylamine, and reacting for 2-4 hours to obtain the N-(4-acetamido-benzylidene)-2, 2-dimethoxyethylamine. And carrying out three steps to obtain the 6-aminoisoquinoline. Wherein the reaction liquid is poured into the crushed ice, an ice bath auxiliary device is used for implementing, and the ice bath auxiliary device comprises an ice crusher (1), a carrying table (2), a heating plate array (3) and a tray (4).

The invention relates to a method for continuously producing 2, 5-dihydroxy-1, 4-dithiane, which comprises the following steps: pre-cooling a chloroacetaldehyde solution and a sodium hydrosulfide solution, mixing in a pipeline mixer, reacting in a reaction kettle, continuously producing, and post-treating to obtain a finished product, the molar yield is more than 95%, the content is more than 98%, the melting point is 140-145 DEG C, and the appearance is white granular crystal. And the requirements of downstream products can be better met. The method has the characteristics of high efficiency, continuous production, stable process, high product quality, high yield, low cost, environmental friendliness and convenience in industrial popularization.

The invention discloses a high-ammonia-nitrogen wastewater treatment process, and belongs to the technical field of pyridine wastewater treatment, and the high-ammonia-nitrogen wastewater treatment process comprises the following steps: preparing hydrotalcite: weighing cobalt nitrate, magnesium nitrate and aluminum nitrate, adding distilled water, and stirring to obtain a salt solution; weighing sodium hydroxide and anhydrous sodium carbonate, adding distilled water, and stirring to obtain alkali liquor; pumping the salt solution and the alkali solution into a round-bottom flask, and heating and dispersing the round-bottom flask on an oil bath pan; putting the ground sample into a ceramic crucible, calcining in a muffle furnace, weighing a silver-ammonia solution and acetaldehyde, and pouring into a round-bottom flask; the pyridine wastewater is weighed, the hydrotalcite is added, stirring adsorption is performed for 20 min, the hydrogen peroxide is added, suction filtration is performed after the reaction, and the hydrotalcite is filtered and separated out for recycling. The problem that existing wastewater treatment is difficult is solved. The method has the advantages of high catalytic activity, easiness in recovery and reutilization of hydrotalcite, no need of adding any auxiliary chemical reagent, mild reaction conditions, low cost and convenience in operation, and can meet the requirements of industrial production.

The present application provides a kind of for the preparation of C 3+ The application discloses a catalyst for olefin, a preparation method and application, the catalyst is supported by a molecular sieve, and the molecular sieve is MFI molecular sieve or SBA-16 molecular sieve, and the catalyst is loaded with multi-metal, and the multi-metal includes metal tungsten, transition metal and alkali metal. The catalyst is used for providing Lewis acid sites by introducing metal tungsten into MFI molecular sieve or SBA-16 molecular sieve by one-step process, and further selectively introducing transition metal and alkali metal. By selectively coupling hydrogenation-dehydrogenation sites, C-C coupling sites and alkali metal sites in the same multifunctional catalyst, the synergies between the molecular sieve carrier and the multi-metal are realized. The catalyst realizes high-efficiency ethanol-to-C 3+ Olefins conversion in ethanol, with acetaldehyde as the reaction intermediate, and has the advantages of high C 5+ Olefins selectivity.

The invention discloses a copper-based catalyst for preparing acetaldehyde through ethanol dehydrogenation as well as a preparation method and application of the copper-based catalyst. The preparation method comprises the following steps: S1, carrying out alkalization treatment on protic mordenite in a strong alkali solution to increase the number of surface hydroxyl groups of the protic mordenite; and S2, adding the mordenite obtained in the step S1 into a copper salt solution to load copper ions, and then sequentially carrying out low-temperature drying shaping and medium-temperature activation stages to obtain the copper-based catalyst with networked Cu-OH-Si-O bonds on the surface. Through the synergistic effect of alkali liquor regulation and control and staged oxygen roasting, the dispersity and stability of a Cu active center in the catalyst are improved, the acetaldehyde selectivity of the reaction of preparing acetaldehyde through ethanol dehydrogenation is also improved, and side reactions are inhibited. Carrying out heat treatment regeneration on the inactivated copper-based catalyst in an oxygen-containing atmosphere; and after regeneration, the networked Cu-OH-Si-O bond on the surface of the copper-based catalyst is reconstructed.

A Levodopa-selective sensor is provided. A continuous levodopa monitor is also provided. The levodopa sensor includes a sensor area having a working electrode with a levodopa-selective chemistry configured for at least partial implantation in a host. The sensor also includes at least one membrane adjacent the levodopa-selective chemistry. The at least one membrane includes an enzyme domain that at least one enzyme selected from a tyrosinase; a mutated tyrosinase with specificity towards I-3,4-dihydroxyphenylalanine; a dihydroxyphenylalanine 4,5-dioxygenase; a mutated dihydroxyphenylalanine 4,5-dioxygenase with specificity towards I-3,4-dihydroxyphenylalanine; and combinations thereof; a synthase enzyme with specificity towards I-3,4-dihydroxyphenylalanine; a mutated synthase enzyme with specificity towards I-3,4-dihydroxyphenylalanine; a 3,4-dihydroxyphenyl-acetaldehyde synthase; a mutated 3,4- dihydroxyphenyl-acetaldehyde synthase with specificity towards I-3,4-dihydroxyphenylalanine; a dioxygenase enzyme with specificity towards I-3,4-dihydroxyphenylalanine; and a mutated dioxygenase enzyme with specificity towards I-3,4-dihydroxyphenylalanine.

The invention provides a device for preparing pentaerythritol through continuous condensation reaction and a reaction method thereof. The device comprises an enhanced reaction tower and a plug flow reactor which are connected in sequence, wherein a strengthening unit is arranged at the bottom in the strengthening reaction tower, an acetaldehyde feeding hole is formed in the lower part of the strengthening reaction tower, and the acetaldehyde feeding hole is formed in the lower part of the strengthening unit; an alkali liquor feeding hole, a formaldehyde feeding hole and a circulating feeding hole are sequentially formed in the upper part of the enhanced reaction tower from top to bottom; a discharge hole is formed in the bottom of the enhanced reaction tower; a spray layer is arranged at the top in the enhanced reaction tower, the spray layer is connected with the alkali liquor feed port, a liquid level sensor is arranged below the spray layer, and the liquid level sensor is arranged at a position 0.2-2 m below the spray layer; preferably, the liquid level sensor is arranged at the position 0.8 m below the spraying layer. According to the device disclosed by the invention, reactants are continuously fed, and products are continuously produced, so that the reaction rate is obviously accelerated.

The invention belongs to the technical field of catalysts, and particularly relates to a Na-modified Zn-coated MFI molecular sieve monatomic catalyst and a preparation method and application thereof. The catalyst is represented by a formula Zn-Na at MFI, Zn and Na are active components, the MFI molecular sieve carrier and Zn are dispersed in the MFI molecular sieve carrier in a monatomic form, and the loading capacities of the active components Zn and Na in the catalyst are 0.1-1 wt% and 0.2-2 wt% respectively. The catalyst provided by the invention realizes 100% of atom utilization rate in a reaction for preparing acetaldehyde through ethanol dehydrogenation, and can realize high-activity, high-selectivity and high-stability generation of a target product acetaldehyde from ethanol under mild reaction conditions. Compared with an existing metal molecular sieve catalyst for preparing acetaldehyde through ethanol dehydrogenation, the catalyst provided by the invention has the remarkable advantages of good stability and high selectivity.

The invention discloses a genetically engineered probiotic composition for expressing ADH (adenosine dihydrogenase) and ALDH (aldehyde dehydrogenase) and application of the genetically engineered probiotic composition in hangover alleviating and liver protection. The genetically engineered probiotic composition (such as EcN.1917-ADH and EcN.1917-ALDH) is constructed by introducing genes of alcohol dehydrogenase (ADH, NCBI (National Center for Biotechnology Information) Gene ID: 855349) and acetaldehyde dehydrogenase (ALDH, NCBI Gene ID: 855206) of saccharomyces cerevisiae into probiotics (such as escherichia coli). The engineering bacterium shows remarkable ethanol, acetaldehyde and endurance capacity in an in-vitro experiment, and the ethanol degradation rate is remarkably higher than that of a wild type strain; a mouse drunkenness model verifies that drunkenness and death caused by drinking can be reduced through pretreatment, drunkenness tolerance time is remarkably prolonged, and movement coordination disorder caused by alcohol can be improved. The strain can effectively promote alcohol metabolism and relieve alcoholic liver injury, and a new candidate strain is provided for development of a hangover-alleviating and liver-protecting viable bacterial preparation.