Patents
Literature
Patsnap Eureka AI that helps you search prior art, draft patents, and assess FTO risks, powered by patent and scientific literature data.

4270 results about "High activity" patented technology

Carbonyl reductase mutant and application thereof in synthesis of statin drug intermediates

The invention provides a carbonyl reductase mutant. The carbonyl reductase mutant is obtained by performing single-point mutation or multi-point combined mutation on the 17th site, the 40th site and the 64th site of an amino acid sequence as shown in SEQ ID NO.1. The invention also provides a coding gene, a recombinant vector containing the coding gene, a co-expression engineering bacterium and an application of the co-expression engineering bacterium. Compared with a wild type enzyme, the carbonyl reductase mutant has high activity and high stereoselectivity, the enzyme activity can reach more than two times that of the wild type enzyme, the catalytic efficiency on a substrate precursor ketone is remarkably improved, the yield of a statin drug intermediate and chiral alcohol synthesized by an enzyme method of the carbonyl reductase mutant is remarkably improved, and the yield of a rosuvastatin intermediate (3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R, 3R) is remarkably improved. The highest yields of the (3R, 5R)-6-chloro-3, 5-dihydroxyhexanoic acid tert-butyl ester and the atorvastatin intermediate (3R, 5R)-6-cyano-3, 5-dihydroxyhexanoic acid tert-butyl ester reach 99% and 97.6% respectively, e.e. Is larger than 99%, and the method has high industrial application value.
Owner:ZHEJIANG UNIV OF TECH

Recombinant A type humanized XVII type collagen as well as construction and application thereof

The invention relates to a recombinant A type humanized XVII type collagen as well as construction and application thereof, the protein is the humanized XVII type collagen which is composed of an intracellular region, a transmembrane region and an extracellular region, and the amino acid sequence is as shown in SEQ No. 1. The hair follicle repairing agent has the advantages of hair follicle repairing, hair regeneration, good biological activities of cell proliferation, cell adhesion and the like, and can be widely applied to the fields of medicines, medical instruments, biological materials, tissue engineering, cosmetics and the like. The gene sequence of the recombinant A type XVII collagen is 100% identical to the corresponding part of the gene sequence of the recombinant A type XVII collagen, so that the recombinant A type XVII collagen has good hydrophilicity and high activity, and has application potential in the fields of biomedical materials, beauty cosmetics, skin care products and the like.
Owner:ZHEJIANG JIBEI BIOTECHNOLOGY CO LTD +1

High-strength and high-toughness aluminum nitride ceramic and preparation method thereof

The invention discloses a high-strength and high-toughness aluminum nitride ceramic and a preparation method thereof, and relates to the technical field of ceramics, a sol-gel method is adopted to coat the surface of aluminum nitride with a stable shell layer to form a core-shell structure, meanwhile, the low lattice mismatch rate of a core-shell interface is utilized to reduce thermal resistance, and toughness and thermal conductivity are both considered; according to the external magnetic field tape casting method, the magnetic dipole moment orientation principle is utilized, an external magnetic field is applied in the tape casting stage, the in-plane mechanical property is improved, and the fracture toughness is improved through the magnetism of aluminum nitride whiskers; a reinforcement is introduced to improve the mechanical property and corrosion resistance of the aluminum nitride ceramic material, multi-granularity powder is compounded, large-particle aluminum nitride powder is used as a sintering and heat-conducting framework material, and high activity provided by submicron particles is utilized to promote sintering, so that the sintering temperature of aluminum nitride can be remarkably reduced, and the performance is greatly improved; and the aluminum nitride substrate expands more application fields on a future packaging circuit.
Owner:四川富乐华半导体科技有限公司 +1

Intelligent production control system for high-activity selenium yeast based on gradient feeding monitoring

The invention relates to the technical field of program control, and discloses a high-activity selenium yeast intelligent production control system based on gradient feeding monitoring. The system comprises a data acquisition module, a control parameter acquisition module, a gradient calculation module, an intelligent control module and a material supplementing control module. The system collects process production data, extracts key control parameters and weights, calculates real-time gradient values of the parameters, forms six-dimensional gradient vectors, generates control gradient indexes in combination with the parameter weights and time sequence attenuation weights, and then forms an addition control decision. And according to the decision and the process state dynamic data, the material supplementing opportunity is identified, an active adding instruction is generated, programmed control and adjustment of the raw materials and the additives are achieved, and the control precision and the production automation level are improved.
Owner:芜湖华信生物药业股份有限公司

Preparation method of calcium hydroxide with high specific surface area

The invention belongs to the technical field of calcium hydroxide preparation, and particularly relates to a preparation method of calcium hydroxide with high specific surface area, which comprises the following steps: S1, adding triethanolamine and diethanolisopropanolamine into water, and uniformly mixing to obtain an active agent solution; s2, mixing quick lime with an active agent solution, and carrying out digestion reaction to generate a calcium hydroxide coarse material; and S3, sieving and drying the calcium hydroxide coarse material to obtain the calcium hydroxide with the high specific surface area. The specific surface area of calcium hydroxide can be remarkably increased through the active agent solution, meanwhile, the uniformity and sufficiency of the quick lime digestion reaction are optimized, the calcium hydroxide particle aggregation phenomenon is reduced, and finally the calcium hydroxide product with the high specific surface area and the high activity is prepared.
Owner:XINJIANG LONGXIN ENVIRONMENTAL PROTECTION TECH CO LTD

Peptide with bone strengthening effect as well as preparation method and application thereof

The invention discloses a peptide with a bone strengthening effect as well as a preparation method and application thereof, and relates to the field of biology. The casein is used as a raw material, the high-activity calcium ion chelating peptide and the directional preparation technology thereof are provided, the technology has the advantages of being high in efficiency, low in cost, easy to operate, good in stability and the like, the high-activity calcium ion chelating peptide can be prepared on a large scale, the utilization value of the casein is improved, and a new way is provided for development of functional natural calcium supplement products.
Owner:INNER MONGOLIA DAIRY TECH RES INST CO LTD +2

Preparation method of fuel cell carbon-supported platinum catalyst, catalyst and application

The invention relates to the technical field of fuel cells, and provides a preparation method of a fuel cell carbon-supported platinum catalyst, the catalyst and application, the preparation method comprises the following steps: S1, adding a platinum precursor solution and a carbon material into a solvent, dispersing, drying and grinding to obtain catalyst powder A; s2, performing primary microwave treatment on the catalyst powder A under inert gas to obtain catalyst powder B; and S3, mixing and grinding the catalyst powder B and the platinum precursor solid, and carrying out secondary microwave treatment under inert gas to obtain the carbon-supported platinum catalyst. The preparation method has the advantages that through two-step microwave treatment, the particle size of the platinum particles inside and outside the pores of the carbon carrier is accurately controlled under the condition that the high activity of the platinum particles is kept, so that the carbon-supported platinum catalyst has the advantages of high performance, high stability and durability, and meanwhile, the performance of the catalyst is not influenced under the low-humidity working condition.
Owner:SINOHYKEY TECHNOLOGY FOSHAN CO LTD

Rare-earth metal arylamine group compound as well as preparation method and application thereof

The invention discloses a rare-earth metal arylamine group compound as well as preparation method and application thereof. The invention discloses the rare-earth metal arylamine group compound which is characterized in that a general formula of the rare-earth metal arylamine group compound is (2,6-R12PhNH)5LnLi2(THF)2, wherein Ln is a rear-earth metal selected from one of neodymium, samarium, ytterbium or yttrium; R1 is selected from one of hydrogen, methyl or isopropyl. The rare-earth metal arylamine group compound has the advantages that the rare-earth metal arylamine group compound has a definite structure; raw materials used in the preparation method are simple, easily obtained and cheap; the reaction process is simple and easily operated; the rare-earth metal arylamine group compound product is conveniently purified and the yield of the product is high; the rare-earth metal arylamine group compound has a high activity when acting as a single component catalyst to catalyze a hydrogen phosphine reaction of aldehyde or ketone and phosphite ester; the use amount of the catalyst is less; the yield is high; a substrate has wide universality; a new and simple method is provided for synthesis of a-hydroxyphosphonate.
Owner:SUZHOU UNIV

Method for preparing phosphatidylserine through interfacial enzyme catalysis

The invention belongs to the field of enzymatic preparation of structural phospholipids, and particularly relates to a method for preparing phosphatidylserine through interfacial enzyme catalysis. A series of high-activity immobilized phospholipase are prepared by innovatively adopting bifunctional group modified hollow mesoporous silica microspheres as a carrier and adsorbing immobilized phospholipase D. The catalyst has the functions of a catalyst and an emulsifier, and a Pickering emulsion interfacial enzyme catalysis system can be efficiently constructed. In the system, the phosphatidylcholine and the serine are efficiently converted into the phosphatidylserine through a phosphatidyl transfer reaction, the conversion rate of the phosphatidylserine within 20 minutes can reach 85%-95%, and the catalytic efficiency reaches up to 372 mmol / (g.h). In addition, after the catalyst is recycled for 10 times, the conversion rate is still kept at 70.9%, and the catalyst shows excellent stability and reusability. The method has the remarkable advantages of being mild in reaction condition, high in catalytic efficiency, capable of being repeatedly used and the like, and a new technical approach is provided for industrial production of phosphatidylserine.
Owner:OIL CROPS RES INST CHINESE ACAD OF AGRI SCI

High-activity short-cut nitrification rapid start and long-term stable operation technology

The invention discloses a high-activity short-cut nitrification quick-start long-term stable operation process, which relates to the technical field of biological sewage treatment, and comprises the following steps: inoculating sludge, carrying out anaerobic fermentation pretreatment, and removing expanded sludge and sludge foam in combination with quick sludge discharge and manual removal; controlling the number of days of sludge age, reproliferating the sludge, enriching ammonia oxidizing bacteria, and inhibiting and elutriating nitrite oxidizing bacteria; long-term operation is carried out under the condition of no sludge discharge, the abundance and activity of ammonia oxidizing bacteria are maintained, and meanwhile, the abundance of nitrite oxidizing bacteria is controlled; the proliferation of nitrite oxidizing bacteria is controlled by using the predation effect of protozoa and metazoan, and the accumulation rate of nitrite in the reactor is controlled; monitoring the dissolved oxygen, the pH value and the concentrations of ammonia nitrogen, nitrite nitrogen and nitrate nitrogen in the reactor in real time, and regulating and controlling the influent ammonia nitrogen load and the free ammonia concentration; dissolved oxygen distribution is adjusted in an intermittent aeration or microporous aeration mode, and the operation conditions of the short-cut nitrification reactor are optimized. The method is simple to operate, economical and effective.
Owner:胡高原

High-stability hydroxysteroid dehydrogenase mutant, co-immobilized enzyme construction method and application

The invention discloses a high-stability hydroxysteroid dehydrogenase mutant, a co-immobilized enzyme construction method and application. According to the invention, a site-directed mutant library is constructed based on computer-aided design, and mutants with significantly improved thermal stability and greatly improved catalytic efficiency compared with wild type mutants are obtained through screening; meanwhile, a co-immobilized enzyme construction method based on electrostatic adsorption and chemical crosslinking is established, the hydroxysteroid dehydrogenase mutant and lactic dehydrogenase are co-immobilized, the co-immobilized enzyme can still keep high activity under high substrate concentration, and the conversion rate is still maintained to be 90% or above after 30 batches of co-immobilized enzyme are repeatedly used. And an important foundation is laid for industrial application of the hydroxysteroid dehydrogenase.
Owner:ZHEJIANG UNIV OF TECH

Preparation method of high-activity transition metal phosphide catalyst

The invention relates to a preparation method of a high-activity transition metal phosphide catalyst, which comprises the following steps: taking basic nickel cobalt carbonate (NiCo-OH / NF) grown on foamed nickel in situ as a precursor, placing the precursor at the downstream of a tubular furnace, placing NaH2PO2 at the upstream of the tubular furnace, annealing in a nitrogen atmosphere at 350 DEG C for 2 hours, and naturally cooling to obtain NiCoP / NF; the preparation method comprises the following steps: soaking NiCoP / NF in a potassium salt solution of a boride, washing, and carrying out vacuum drying to obtain a boron-potassium modified catalyst precursor NiCoP-BK / NF; in a three-electrode system, electrodeposition is carried out in an electrolyte containing a Ni source, a Fe source and deionized water, and the high-activity transition metal phosphide-nickel iron hydroxide NiCoP-BK-coated NiFe-LDH / NF heterojunction composite catalyst is obtained. The activity and stability of the transition metal phosphide catalyst can be remarkably improved, and the preparation method is simple and low in cost.
Owner:NORTHEAST GASOLINEEUM UNIV

Inositol dehydrogenase mutant and preparation method of D-chiral inositol

The invention discloses an inositol dehydrogenase mutant and a preparation method of D-chiral inositol, and belongs to the technical field of genetic engineering. The inositol dehydrogenase mutant is obtained by mutating an amino acid sequence as shown in SEQ ID NO.2 through the following mutations: the 200th amino acid is mutated into C from V, the 234th amino acid is mutated into Q from V, and the 256th amino acid is mutated into E from R. According to the invention, the amino acid sequence of wild type inositol dehydrogenase is mutated to obtain the inositol dehydrogenase mutant which is a high-activity mutant capable of catalyzing conversion of myo-inositol into 2-keto-myo-inositol; therefore, when the inositol dehydrogenase mutant and keto isomerase act together to prepare D-chiral inositol by taking myo-inositol as a substrate, the yield of the D-chiral inositol is effectively improved.
Owner:ZHUCHENG HAOTIAN PHARMA CO LTD

High-activity enzyme, screening method and application

The invention discloses a high-activity enzyme, a screening method and application, which combine far-end potential site saturation test and iterative screening to accelerate the development of high-thermal-stability and high-activity bio-enzyme and effectively solve the problems of complicated screening steps and limited screening range of the existing high-activity bio-enzyme. The mutant obtained through strategy transformation can be used for efficiently synthesizing pharmaceutical chemicals and has relatively high industrial production application value.
Owner:ZHEJIANG UNIV OF TECH

High-activity PET hydrolase mutant and application thereof

The invention belongs to the field of biological catalysis, and discloses a high-activity PET hydrolase mutant and application thereof. The mutant of the thermophilic PET hydrolase provided by the invention is as shown in 1), 2) or 3): 1) a protein corresponding to an amino acid sequence SEQ ID NO.4; 2) a protein corresponding to the amino acid sequence of SEQ ID NO.6; and 3) a protein corresponding to the amino acid sequence of SEQ ID NO.8. Experiments prove that the modified mutant shows higher catalytic efficiency on PET hydrolysis and can keep activity for a long time at the optimal temperature for PET depolymerization. The activity of the mutant protein BhrM3 for catalyzing PET hydrolysis is improved by 1.82 times compared with that of a wild type and is 1.22 times that of efficient PET hydrolase LCC-ICCG, and the protein melting temperature reaches 92.9 DEG C.
Owner:BEIJING UNIV OF CHEM TECH

Catalyst for sulfuric acid production

The invention belongs to the technical field of chemical engineering, and particularly relates to a catalyst for sulfuric acid production. The samarium element is doped in the vanadium catalyst, so that the oxygen adsorption capacity of the vanadium catalyst is effectively improved, and the catalytic activity and low-temperature activity of the vanadium catalyst are improved; the modified diatomite and the mesoporous material are selected to jointly form the carrier, so that the dispersity of the active component on the catalyst can be improved, and the catalytic activity of the catalyst can be improved; diatomite is modified by adopting a dilute sulfuric acid solution under an ultrasonic condition, so that the specific surface area of the diatomite is increased, and the catalytic activity of the vanadium catalyst is improved; the vanadium catalyst is prepared by adopting an impregnation method, so that the problem of non-uniform dispersion of active components caused by a mixing and grinding method is effectively avoided, and the catalytic activity of the catalyst is further improved.
Owner:HUBEI LONGXIANG PHOSPHATE

Ultrahigh-strength prestressed concrete pipe pile and preparation method thereof

The invention discloses an ultrahigh-strength prestressed concrete pipe pile and a preparation method, and relates to the technical field of building materials. The ultrahigh-strength prestressed concrete pipe pile comprises a core layer which is composed of 1.0%-2.0% by volume of chopped basalt fiber reinforced concrete, the fiber length is 8-12 mm, the diameter is 15-20 microns, and the compressive strength is larger than or equal to 130 MPa; the transition layer is composed of hybrid fiber reinforced concrete with the volume fraction of 3.0%-4.0%, steel fibers account for 60%-75%, polyethylene fibers account for 25%-40%, the length-diameter ratio of the steel fibers is 50-80, and the tensile strength is larger than or equal to 1200 MPa. Through gradient fiber reinforced structure design and preparation process innovation, the mechanical property, the production efficiency and the environmental friendliness of the prestressed concrete pipe pile are synergistically improved. Firstly, in the aspect of mechanical properties, the compressive strength is made to break through 130 MPa through the synergistic effect of the core layer basalt fiber and the high-activity superfine slag powder and is improved by 30% or above compared with a traditional C100 pipe pile, and meanwhile the shear strength is improved to 18 MPa or above through a transition layer steel-polyethylene hybrid fiber system.
Owner:HUZHOU XINHE NEW BUILDING MATERIALS CO LTD

Catalyst as well as preparation method and application thereof

The invention belongs to the technical field of petroleum processing, and particularly relates to a catalyst and a preparation method and application thereof. The raw materials of the catalyst comprise a metal active component, a carrier and an auxiliary agent, the metal active component is sulfides of Mo and Ni elements, the carrier is spherical gamma-Al2O3 of 0.5-1 mm, and the auxiliary agent is P; the carrier is modified by using the metal active component and the auxiliary agent to serve as the catalyst. The high-activity catalyst is synthesized by adopting the strategy of changing the roasting temperature, adding the additive for doping modification and changing the molar ratio of metal active components, the additive is combined with surface aluminum atoms, the framework strength is enhanced, pore channel collapse caused by acid / water erosion is reduced, the water resistance and acid resistance of the catalyst are improved, and the catalytic reaction activity is further improved. The catalyst disclosed by the invention is accurate and controllable in structure, can be synthesized in batches, and can be applied to the co-catalytic hydrogenation process of biomass pyrolytic oil and / or a model compound thereof and petroleum distillate oil and / or VR.
Owner:CHINA UNIV OF PETROLEUM (EAST CHINA)

Surface-enhanced tryptophan modified nanofiltration membrane as well as preparation method and application thereof

The invention discloses a surface-enhanced tryptophan modified nanofiltration membrane as well as a preparation method and application thereof. Belongs to the field of water treatment membrane preparation. The invention aims to solve the technical problems of non-uniform pore size distribution and surface hydrophobicity of the conventional nanofiltration membrane. The method comprises the following steps: adding tryptophan into a piperazine water-phase solution, and carrying out interfacial polymerization with oil-phase trimesoyl chloride to prepare the tryptophan modified nanofiltration membrane. According to the preparation method, the diffusion rate of the piperazine monomer can be adjusted in the interfacial polymerization process by utilizing a similar surfactant structure of tryptophan, meanwhile, the tryptophan has hydrophilicity and can improve the hydrophilicity of the surface of an active layer, and the prepared modified nanofiltration membrane is reduced in molecular weight cut-off, improved in surface hydrophilicity and good in water resistance. The retention rate of organic micro-pollutants is improved, and meanwhile, good anti-pollution performance is achieved.
Owner:HARBIN INST OF TECH

High-activity contact silver powder, preparation method and photovoltaic conductive silver paste

The invention provides high-activity contact type silver powder for photovoltaic conductive silver paste, a preparation method of the high-activity contact type silver powder and the photovoltaic conductive silver paste, and belongs to the technical field of photovoltaic materials. The high-activity contact type silver powder comprises net-shaped polycrystalline spherical silver powder and an active layer wrapping the surface of the net-shaped polycrystalline spherical silver powder. Wherein the reticular polycrystalline spherical silver powder is a spherical aggregate formed by stacking and self-assembling flaky particles with the particle size of 200-600 nm, and the reticular polycrystalline spherical silver powder is of a porous structure; and the active layer is an organic amine compound. The silver powder disclosed by the invention has good conductivity after being sintered, the adhesive force of a fine grid is relatively high, and the assembly has relatively high power output.
Owner:NANTONG LIANSHENG NEW MATERIAL TECH CO LTD

Medium-high molecular weight high-activity polyisobutene and preparation method thereof

PendingCN120081968APolymer sciencePtru catalyst
The invention provides medium-high molecular weight high-activity polyisobutene and a preparation method thereof, and the preparation method comprises the following steps: mixing hydrogen peroxide and a butyl rubber solution, and reacting for 0.5-20 hours at 20-80 DEG C under the catalytic action of a catalyst to obtain epoxidized butyl rubber; dissolving epoxidized butyl rubber to obtain an epoxidized butyl rubber solution; adding an oxidative cracking reagent into the epoxidized butyl rubber solution, and reacting at 0-80 DEG C for 0.5-20 hours to obtain a polyisobutylene solution; the medium-high molecular weight high-activity polyisobutene has the characteristics of high molecular weight, narrow distribution and higher end group activity, and can be applied to the application fields of traditional high-activity polyisobutene such as additives of lubricating oil, fuel oil, rubber and the like; and the product can be used as a sealing material, a waterproof water-retaining agent, a rubber and plastic modifier and the like, can meet wider application requirements, and has good industrial application value.
Owner:QUZHOU RES INST OF ZHEJIANG UNIV

Preparation of high-activity Cu / ZnO / SiO2 catalyst and reverse water gas shift reaction

The invention belongs to the technical field of catalysis, and particularly relates to preparation of a high-activity Cu / ZnO / SiO2 catalyst and a reverse water gas shift reaction. Aiming at the problems of low reaction activity of low-temperature RWGS, low selectivity of a target product CO and the like in the existing Cu / ZnO-based catalyst, the invention prepares a novel Cu / ZnO / SiO2 catalyst which is used for promoting the reaction activity of medium-low-temperature reverse water gas shift. According to the invention, the polyhydroxy high-molecular compound is adopted to replace a part of small-molecular solvent, the novel Cu / ZnO / SiO2 catalyst with a silicon source, copper and zinc highly dispersed in mesoporous SiO2 is obtained by utilizing the polyhydroxy characteristic and low degree of freedom of the polyhydroxy high-molecular compound, and when the novel Cu / ZnO / SiO2 catalyst is used for a medium-low temperature reverse water gas shift reaction, the reaction activity can be effectively improved to 58%, and the reaction time can be shortened to 30-50 minutes. Meanwhile, the selectivity of the target product CO is 99% or above. The method has the advantages of low catalyst cost, high reaction efficiency, simple process operation and the like, and has a good industrial application prospect.
Owner:TAIYUAN INST OF TECH

MWW molecular sieve and preparation method thereof

The invention discloses an MWW molecular sieve and a preparation method thereof, and the preparation method comprises the following steps: (a) mixing an alkali source, water, an aluminum source, a template agent and a silicon source to form a mixture A; (b) adding nano cellulose into the mixture A to form a mixture B, and pretreating, crystallizing and drying the mixture B to obtain the MWW molecular sieve. The preparation method disclosed by the invention is simple and convenient, easy to industrialize and wide in application prospect, and the MWW molecular sieve with the single-layer structure is prepared. The MWW molecular sieve with a single-layer structure can expose more active sites, promotes diffusion and mass transfer, shows excellent performance in many reaction processes, and particularly shows high activity and stability in a reaction with macromolecules as a substrate.
Owner:DALIAN INSTITUTE OF CHEMICAL PHYSICS CHINESE ACADEMY OF SCIENCES

Carbonyl reductase mutant and application thereof in enzymatic synthesis of chiral alcohol

The invention relates to the technical field of biology, and discloses a carbonyl reductase mutant and application thereof in enzymatic synthesis of chiral alcohol. The amino acid sequence as shown in SEQ ID NO.2 is subjected to mutation that 36th lysine is mutated into any one of aspartic acid, threonine and valine, or / and 125th histidine is mutated into any one of lysine, serine and leucine, or 170th histidine is mutated into any one of lysine, cysteine and leucine. The carbonyl reductase mutants, especially single-site mutants Mut-T75K, Mut-T75D and Mut-E216M and a combined mutant Mut-T75K-E216M, with activity improved to different extents compared with that of a wild type are obtained, have excellent relative enzyme activity, thermal stability and substrate tolerance, have relatively high activity and stability for various chiral alcohols, and can be used for preparing the carbonyl reductase mutants. The catalyst has the advantages of high catalytic activity, high thermal stability, strong substrate tolerance, easiness in fermentation and the like.
Owner:ZHEJIANG UNIV OF TECH

Screening method of liquid crystal polyarylester synthesis catalyst

The invention belongs to the field of liquid crystal polyarylester synthesis, and particularly relates to a liquid crystal polyarylester synthesis catalyst screening method, which comprises: (a) respectively carrying out molecular modeling and structure optimization on a candidate catalyst and a reactant in a liquid crystal polyarylester synthesis reaction; (b) carrying out electronic structure analysis through the optimized structure, determining the number of active sites of the candidate catalyst, and preliminarily predicting the activity of the catalyst; (c) respectively constructing a micro-scale catalyst-reactant interaction model and a mesoscale catalyst-reactant interaction model by the catalyst structure and the reaction active site, and calculating interaction energy under the two scales; and (d) based on the interaction energy result of the multi-scale simulation, screening out a candidate catalyst with the interaction energy absolute value greater than or equal to a set threshold value as a high-activity catalyst. According to the screening method, the experimental screening steps of the liquid crystal polyarylester synthesis catalyst are simplified, and the raw material cost and the time cost are greatly saved.
Owner:ZHEJIANG JULING NEW MATERIALS CO LTD +2

Immobilized lipase taking graft modified amino resin as carrier and preparation method of immobilized lipase

The invention relates to the field of immobilized enzymes, in particular to immobilized lipase with graft-modified amino resin as a carrier and a preparation method thereof.The method comprises the steps that firstly, the amino resin is modified through the oxidative auto-polymerization characteristic of tannic acid, and first modified amino resin is obtained; and modifying the first modified amino resin by using fatty amine as a hydrophobic modifier to obtain second modified amino resin. Then lipase is fixed on the second modified amino resin through physical adsorption, the lipase is subjected to interfacial activation on an amphiphilic interface on the second modified amino resin, and a part of lipase is covalently bound with quinonyl in an activated state, so that the immobilized lipase with high activity and stability is obtained. The method is easy to operate, green and non-toxic, the prepared immobilized lipase is good in enzyme activity and stability, and the method can be used for preparing the immobilized lipase on a large scale, can be applied to the field of food and has industrial application potential.
Owner:NANCHANG UNIV

Lysing bacteriophage for preventing and controlling vibrio in aquaculture environment

The invention discloses a lytic bacteriophage for preventing and controlling vibrio in an aquaculture environment. The bacteriophage vBValMR42H belongs to a muscle tail bacteriophage and is insensitive to chloroform, the capsid of the bacteriophage vBValMR42H is free of lipid substances, and the preservation number is GDMCC No: 67434-B1. The bacteriophage has the characteristics of high adsorption speed, short incubation period and high cracking amount, keeps high activity in a wide range of temperature (4-55 DEG C) and pH (2-11), and has strong environmental adaptability. Genome analysis shows that the bacteriophage does not contain virulence factors, antibiotic resistance genes and lyogen related genes, and is high in biological safety. Physical development analysis shows that the method can be divided into a new genus. The bacteriophage R42H has the advantages of high splitting efficiency, good environmental stability, strong specificity, gene safety and the like, and can be used as an ideal biological prevention and control agent for preventing and controlling vibrio alginolyticus diseases in aquaculture.
Owner:SHENZHEN UNIV

Multiple nano emulsion adjuvant and preparation method thereof

The invention relates to the technical field of pharmaceutical preparations, in particular to a multiple nano emulsion adjuvant and a preparation method thereof. The multiple nano emulsion adjuvant is prepared from 2.73 to 6.37 g of an oil phase matrix based on 100 g of a raw material system, 0.10 to 0.25 g of a sterol compound; 0.212 to 0.424 g of a nonionic surfactant; 0.00050 to 0.00200 g of a triterpenoid saponin type active adjuvant; 0.010 to 0.020 g of an anionic polymer modifier; 0.005 to 0.015 g of a cationic polymer modifier; 70-90 g of a buffer solution; the total mass of the raw materials is 100 g. The nano emulsion adjuvant prepared by the invention can be stored for 6 months at 2-8 DEG C under a low sterol condition, the particle size change does not exceed + 5%, no crystallization or layering is generated, and the stability of the active adjuvant is remarkably improved.
Owner:JIANGSU WALVAX BIOTECHNOLOGY CO LTD

Water-resistant carbon-coated current collector as well as preparation method and application thereof

The invention provides a water-resistant carbon-coated current collector as well as a preparation method and application thereof, and relates to the technical field of batteries. Specifically, the method comprises the following steps: preparing a core-shell type composite binder; the core layer is obtained by polymerizing raw materials including a first monomer, a second monomer and a cross-linking monomer, and the shell layer is obtained by polymerizing raw materials including a third monomer, a fourth monomer and a functional monomer; preparing conductive slurry containing a conductive material and a dispersing agent, fully mixing the conductive slurry with the core-shell type composite binder, and adjusting the pH value to obtain pre-coating slurry; and coating the surface of a metal foil with the carbon-coated current collector, and carrying out heat treatment to obtain the carbon-coated current collector. The binder disclosed by the invention has high water resistance, can effectively prevent a carbon-coated coating from falling off when an active coating is coated, and improves the stripping force of the active coating, meanwhile, the core-shell structure of the binder prevents the surface of a conductive agent from being excessively wrapped, and specific functional groups form strong interface bonding, so that the carbon-coated coating and an interface are compounded more tightly, and the service life of the conductive agent is prolonged. And the coating resistance of the carbon coating layer and the diaphragm resistance of the coated pole piece can be effectively reduced.
Owner:HUNAN GREEN POWER MATERIAL CO LTD

Ultra-dispersed high-activity silicon mortar, preparation method and application thereof, and component

The invention relates to the technical field of concrete admixtures, in particular to ultra-dispersed high-activity silica mortar, a preparation method and application thereof and a component, the ultra-dispersed high-activity silica mortar comprises silica mortar, the silica mortar contains polyelectrolyte, and the pH value of the silica mortar is 8-13; the polyelectrolyte is a linear carboxylic acid polymer and a salt thereof. The pH value of the silica fume slurry is adjusted to 8-13, and the dispersion effect of the polyelectrolyte containing carboxylic acid groups is combined, so that the charge property of the surfaces of silica fume particles is changed, the absolute value of the ZETA potential is increased, the highest absolute value of the ZETA potential can reach 50 mV or above, the strong negative electricity on the surfaces of the silica fume particles enables the particles to generate the electrostatic repulsion effect, and the particles are prevented from being damaged. The silicon ash particles can be effectively prevented from getting close to each other and being agglomerated by matching with the steric hindrance of the polyelectrolyte containing the carboxylic acid group, so that the dispersity of the silicon ash slurry is further improved, the dispersion stability is good, and the suspension rate in 30 days is basically 99.5% or above.
Owner:SICHUAN SHUDAO CONSTR TECH CO LTD