1463 results about "Triterpene" patented technology

Compositions and methods for the prevention and treatment of neoplastic diseases are described. Individuals at a high risk of developing or having neoplasia undergoing conventional therapies may be treated with an effective dose of triterpene derivatives in limonoids, polyphenolic flavonoid compounds, tocotrienols or a combination of these agents.

A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.

The present invention provides for pharmaceutical compositions that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides for a cosmetic formulation that includes a triterpene (e.g., betulin) and an essential oil (Vicks® Vapor Rub). The present invention also provides a method of treating a fungal infection that includes administering (e.g., topically applying) an effective amount of the pharmaceutical composition to the tissue afflicted with the fungal infection, or the tissue at risk of being afflicted with the fungal infection.

The invention provides a sweet crystal of grosvenor momordica with the type of free sugar and health care and a method thereof, which includes that tetracyclic triterpene water extract is extracted from grosvenor momordicas. The character is that modified starch with certain proportion is added into the tetracyclic triterpene water extract of grosvenor momordica, spray-drying and oven-drying are carried out, then the product is finished after being crushed through 60 mesh sieve. The sweet crystal has the color of light brown, keeps the medicinal function of grosvenor momordica and dissolves in water completely. The solution has good taste and special flavor. After drinking the solution, people do not feel sour in mouth, and the taste of sweet cool can be kept in mouth for a few minutes. The sweet crystal is convenient for use. The added quantity is almost the same as the quantity of the traditional habit.

The invention provides a method of effectively extracting ganoderma triterpenoids and ganoderan from mythic fungus germ entity by ultrasonic-alcohol extracting, complex enzyme-water extracting integration technology. The method is characterized by comprising the steps of: crashing the mythic fungus germ entity, using the ultrasound assisted alcohol extract (ultrasonic-alcohol extracting) to extract the ganoderma triterpenoids, then using complex enzyme assisted water extracting (complex enzyme-water extracting) to prepare ganoderan, then sponging drying to obtain ganoderma triterpenoids and ganoderan extractive. The solvents used by the method used in the invention is safe, innoxious and avoids the pollution to the environment by using chloroform, methanol and other organic solvents in the traditional method. And the invention has the features of low extraction temperature, simple device, convenient operation, low cost, fast speed, high effects and so on. Using the process to comprehensively extract triterpenoids and ganoderan active substances in glossy ganoderma can significantly increase the total active substance yield than the single extracting method.

Compositions and methods for the prevention and treatment of neoplastic diseases and hypercholesterolemia are described. Individuals at a high risk of developing or having neoplasia or hypercholesterolemia undergoing conventional therapies may be treated with an effective dose of triterpene derivatives in citrus limonoids, polyphenolic flavonoid citrus compounds, tocotrienols or a combination of these agents.

The present invention relates to the triterpene compounds improving in brain functions. In particular, the present invention relates to a novel use of the triterpene compounds represented by the Formula 1 for improving decreased memory and a pharmaceutical composition for improving brain functions comprising the triterpene compounds represented by the Formula 1.

A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.

The invention provides methods for the inhibition of inflammation by providing, to a cell, in need thereof, monoterpene compositions that inhibit NF-κB. These compositions may also contain a carrier moiety that renders the monoterpene composition membrane permeable. The carrier may include triterpenoid moieties, sugars, lipids, or even additional monoterpenoid moieties. The composition can also contain additional chemical functionalities. Methods for using these compounds to prevent and treat a wide range of inflammatory conditions, especially, premalignant inflammatory conditions are described.

A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.

Disclosed are skin care compositions exerting a novel complementary dual mode of action in protecting the skin from day-to-day insults. The skin care compositions of the present invention comprise the extract from the liquid endosperm of Cocos nucifera as the principle ingredient along with one or more actives including the fruit rind extracts of Garcinia cambogia, Garcinia indica and Garcinia mangostana, seed coat extract of Tamarindus indicus, Chlorogenic acid extract from the beans of Coffea arabica, seed extracts of Nelumbo species, the leaf extracts of Murraya koenigii and the triterpene pentapeptides of oleanolic acid and ursolic acid. While the extract of Cocos nucifera has been included as a nutritional supplement (a natural cell culture medium) to ensure the maintenance of the viability and constant renewal of the cells of the skin, the other actives have been carefully chosen based on one or more of their effective skin care properties. The compositions of the present invention offer a safe prophylactic / therapeutic management solution to the wide range of pathological states associated with skin insults and the associated psycho-social issues.

An application of the pentacyclo-triterpenoid used as the glycogen phosphorylase for preparing the medicines to treat diabetes, ischemic cardiovascular and cerebrovascular diseases, and tumor is disclosed.

The invention discloses the use of ursane type triterpenoid saponin in preparing medicine for increasing leucocyte and / or platelet which has a general formula (I), the invention also provides a pharmaceutical composition having the action of increasing human leucocyte and / or platelet, which contains ursane type triterpenoid saponin composition having a general formula (I), and pharmaceutically acceptable salts.

The invention pertains to the field of medical technology and provides triterpenoid saponin in camellia seeds, and a preparation method and medical application thereof. The triterpenoid saponin is shown in a general formula (1), wherein, R1 is hydrogen or oxhydryl or acyloxy; R2 is the hydrogen or the acyloxy; R3 is the hydrogen or the acyloxy; R4 is the hydrogen or the acyloxy; R5 is methyl or methylol or aldehyde group or carboxyl or metheyl carboxyl; R6 is the hydrogen or orglycosyl; the preparation method comprises the following steps: macroporous resins are degreased, extracted by ethanol, decocted in water, desugared and decolored to obtain crude total saponins and then go though an opened ODS chromatographic column and repeated HPLC method to obtain the total saponins of camellia seeds and monomer theasaponin. The triterpenoid saponin compounds in the camellia seeds have the functions of protecting gastric mucosa, being antineoplastic, reducing blood sugar and blood fat and thelike and are used for preparing medicaments or health-care foods having the functions of protecting gastric mucosa, being antineoplastic and reducing blood sugar and blood fat.

Two hitherto unreported novel triterpene saponins were isolated in substantially pure form from the root of Ilex pubescens. The chemical structures and some properties of the triterpene saponin fraction have been elucidated to possess anti-inflammatory and analgesic activity. These two novel triterpene saponins and the triterpene saponin fraction may be used as pharmaceutical compositions in humans and mammals in need of such treatment.

The invention relates to the pharmaceutical field, in particular to application of a series of pentacyclic triterpenoid compounds as a cholesterol ester transfer protein (CETP) inhibitor, in particular to application in factors of preparing medicines for treating cardiovascular and cerebrovascular diseases, atherosclerosis diseases and hyperlipemia. The invention further discloses a series of novel pentacyclic triterpenoid compounds, application of the compounds as the CETP inhibitor and a pharmaceutical composition.

The invention discloses total triterpene extract and total phenol extract extracted from Chinese herbal medicine glossy privet fruit and a preparation method thereof. The total triterpene extract mainly contains oleanolic acid, ursolic acid, acetyl oleanolic acid, indicant compound and other derivatives with acetyl oleanolic acid as the mother nucleus. The total phenol extract mainly contains hydroxyl mandelic, 3, 4-dihydroxy phenylethyl alcohol, salidroside and indicant compound and other derivatives with salidroside as the mother nucleus. The glossy privet fruit total triterpene extract and total phenol extract can be prepared by any method of solvent distillation, solvent extraction, deposition, macroporous resin absorption, supercritical fluid extraction, column chromatography and liquid-liquid countercurrent distribution chromatography, or any combination of these methods. The total percentage of various triterpenoids of the prepared glossy privet fruit total triterpene extract is 5 to 100 percent (w / w); wherein, the content of oleanolic acid and ursolic acid accounts for 5 to 100 percent (w / w) of the total triterpene. The total percentage of various phenols of the prepared glossy privet fruit total phenol extract is 5 to 100 percent (w / w); wherein, the content of salidroside accounts for 5 to 100 percent (w / w) of the total phenol.

This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating cancer, arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence and premature ejaculation; for preventing cerebral aging; for improving memory, cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.

The invention provides the application of betulinic acid and salts thereof suitable for medical purpose in the preparation of a drug of a glycosidase inhibitor. The compound of the invention is the compound of lupeol type pentacyclic triterpene acid obtained by separating lagerstroemia plants. Pharmacological tests prove that the compound has obvious effect in inhibiting Alpha-glucosidase, the inhibitory activity of which exceeds acarbose 100% for initial therapy. Therefore, drug compositions made from the compound or the salts thereof suitable for medical purpose and drug excipients or carriers allowable for preparation can be applied to the preparation of drugs for preventing or treating Type II Diabetes, namely, noninsulin-dependent diabetes mellitus. The constitutional formula shown in formula (1) of the invention is shown as above.

This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating breast, leukocyte, liver, ovarian, bladder, prostate, bone or brain cancer. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications, including treating breast, leukocyte, liver, ovarian, bladder, prostate, bone or brain cancer.

The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

The invention provides a camphor tree sesame fruiting body cultivation method which comprises the following steps: culture media containing leaven are taken for fermentation for 3 to 30 days under the temperature of 5 to 35 DEG C; saw dusts are added into the culture media after fermentation and stirred; the saw dusts and the culture media are arranged inside a vessel; the vessel provided with the saw dusts and the culture media is sterilized; camphor tree sesame spawns are taken to be inoculated into the vessel containing the saw dusts and the culture media and cultivated into mycelium under the temperature of 5 to 35 DEG C; saw dusts containing the camphor tree sesame mycelium are inoculated to a bed wood; the bed wood which has been inoculated with the spawns is cultivated under the temperature of 5 to 35 DEG C and in the humidity of 65 to 85 percents; after residual saw dusts on the bed wood are removed, the bed wood is cultivated under the temperature of 15 to 35 DEG C and in the humidity of 80 to 98 percents for a period of time, and a camphor tree sesame fruiting body can be formed. The invention also provides a cultivation method for camphor tree sesame mycelium and the camphor tree sesame fruiting body obtained by cultivation according to the method. The camphor tree sesame fruiting body cultivated by the invention has the characteristics of massiness of the fruiting body and content of triterpene close to wild camphor tree sesame.

An antioxidizing technique for the wall-broken ganoderma spore powder features that an edible powder is mixed with the wall-broken ganoderma spore powder to wrap the oily components easy to be oxidized, such as ganoderic triterpene and unsaturated fatty acid, for isolating them from oxygen.

The invention relates to field of natural medicine and medicinal chemistry, in particular to novel pentacyclic triterpene and melbine salt I of the derivative thereof. The salt compound can be used for preparing medicaments curing diabetes mellitus and complicating disease thereof, cerebral ischemia, angiocardiopathy, atherosclerosis, hepatitis, fatty liver and metabolic syndrome or tumour, descendens blood fat drugs and anti-obesity drugs. The invention also relates to the preparation method of the salt compound.

The invention relates to a tea saponin bath lotion and its making method. The tea saponin bath lotion comprises tea saponin essence and additives. The tea saponin is a pentacyclic triterpene saponin substance, has the performance of emulsifying, dispersing, wetting and foaming, and the pharmacological actions of resisting permeability and reducing inflammation, etc. With an inhibiting effect on a variety of skin pruritus and no toxic or side effect, the tea saponin has the characteristics of abundant foam, durability, strong detergency and the like, and can be compounded with other surfactants to prepare the bath lotion. Without toxic or side effect, the bath lotion has the effects of skin moistening, skin care, and water replenishing.

The invention belongs to the technical field of artificial cultivation of medicinal fungi, and particularly relates to a method for cultivating ganoderma lucidum karst. The method includes the steps of obtaining ganoderma lucidum karst mother species, ganoderma lucidum karst protospecies and ganoderma lucidum karst cultispecies respectively, and conducting substitute cultivation of the ganoderma lucidum karst cultispecies to obtain ganoderma lucidum karst, wherein a cultispecies culture medium is prepared from corn straw, sawdust, pig manure, cow dung, rapeseed meal, humic acid, an amillariella mellea fermented liquid, a bacillus subtilis fermentation liquid and gypsum, and a culture medium of the substitute cultivation is same as the cultispecies culture medium. According to the method, the yield of ganoderma lucidum karst sporophore and conidial powder is significantly improved, and the contents of effective components, like ganoderma lucidum karst polysaccharide and ganoderma lucidum karst total triterpenoid, are significantly improved.

The present invention relates to a kind of active component extracted from glossy ganoderma spore as material and its preparation and use. The glossy ganoderma spore oil contains total triterpene in 24-35 %, has density of 0.88-0.92, refractive index 1.45-1.48 and acid number 14-35. The preparation process with wall breaking glossy ganoderma spore as material includes mixing with alcohol solution, pelletizing, drying, supercritical CO2 extraction in extracting reactor, two-stage separation, and extraction to obtain oily matter, and eccentric separation to obtain yellow oil. The glossy ganoderma spore oil product is used in preparing medicine and food for raising body's immunity. The process of the present invention is simple, stable in product quality, convenient and high in product yield, and is suitable for industrial production.

The invention provides an oleanolic acid triterpenoid, whose A ring and C ring contain multiple oxygen substituents, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell, thereby being applied in the preparation of anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene, thereby being applied in the preparation of anti-inflammatory agent. The formula (1) is represented as above.