77 results about "Erg" patented technology

The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and / or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.

embodiments of the invention include purification of DNA, preferably plasmid DNA, by use of selective precipitation, preferably by addition of compaction agents Also included is a scaleable method for the liquid-phase separation of DNA from RNA. RNA may also be recovered by fractional precipitation according to the invention. RNA, commonly the major contaminant in DNA preparations, can be left in solution while valuable purified plasmid DNA is directly precipitated. Endotoxin can also be kept to very low levels. The invention includes mini-preps, preferably of plasmid and chromosomal DNA to obtain sequenceable and restriction digestible DNA in high yields in multiple simultaneous procedures. As a method of assay, a labeled probe is precipitated by hybridizing it to a target, (erg. chromosomal DNA, oligonucleotides, Ribosomal RNA, tRNA), and thereafter precipitating the probe / target complex with compaction agents and leaving in solution any unhybridized probe.

A bit patterned magnetic recording medium comprises a substrate having a surface, and a plurality of spaced apart magnetic elements on the surface, each element constituting a discrete magnetic domain or bit of the same structure and comprised of a stack of thin film layers including in order from the substrate surface: a seed layer; and a perpendicular magnetic recording layer in contact with a surface of the seed layer and comprising a Co1-x-yPtxCry alloy material, where 0.05≦x≦0.35 and 0≦y≦0.15. The Co1-x-yPtxCry alloy material has a first order magnetic anisotropy constant K, up to about 2×107 erg / cm3, a saturation magnetization Ms up to about 1200 emu / cm3, an anisotropy field HK=2K1 / Ms up to about 35 kOe, a hexagonal (0001) crystal structure with c-axis perpendicular to a surface thereof, and an X-Ray diffraction (XRD) rocking curve with a full width at half maximum (FWHM) of ˜5° or less.

The invention relates to a method for treating ERG-positive prostate cancer patients with an agent counteracting one or more ERG-associated genes and / or manipulating of one or more ERG-related pathways, optionally in combination with an androgen deprivation therapy. Furthermore, the invention concerns methods for screening prostate cancer patients which may benefit from said treatment, assessing the efficacy of a therapy for treating prostate cancer in a patient, assessing progression of prostate cancer in a patient, selecting an agent to be tested for usefulness in the treatment of prostate cancer, and for assessing prostate carcinogenic potential of an agent.

Process and system for determining the topography of bioelectric response signals of a visual system including a patient's retina, optical nerve or a projection thereof at the level of the central cortex, following visual stimulation through a surface arranged in front of the patient's eye. An image which comprises a plurality of cells is displayed as stimulation, each cell being activated or deactivated according to a corresponding digital time function represented by a cyclical succession of binary m-sequences of duration (T) formed from a plurality of activation symbols (N), each having a duration (Ts), the m-sequences of the various cells being obtained cyclically from a mother m-sequence. The process determines the total bioelectric response of the visual system, the response associated with each cell being determined by the total response of the visual system using a cross-correlation with a suitable translated version of a mother m-sequence. The calculation of the response of each cell is updated at the end of each symbol time (Ts), thereby making it possible to follow the evolution of the calculated response of each cell in real-time, without awaiting the end of an m-sequence.

A method for virtualizing an optical network, comprising: abstracting optical resource information corresponding to resources within the optical network, constructing a plurality of candidate paths for one or more optical reachability graph (ORG) node pairs, determining whether the candidate paths are optical reachable paths, and creating an ORG link between each ORG node pair when at least one optical reachable path exists for the ORG node pair, wherein linking the ORG node pairs creates an ORG. In another embodiment, a computer program product comprising executable instructions when executed by a processor causes a node to perform the following: determine an optical network's optical-electrical-optical (OEO) conversion capability, partition a plurality of service sites into one or more electrical reachability graph (ERG) nodes, determine a grooming capability for each ERG node, and construct a plurality of electrical-layer reach paths between the ERG nodes to form an ERG.

A method for predicting with high specificity from RTPCR detected markers if a patent is likely to respond to docetaxel treatment is disclosed. RTPCR detects the presence of absence of certain mutations due to fusion events. Together, with other protein markers, additional stratification is possible to identify patents suited for docetaxel therapy as opposed to for alternative treatments.

The invention relates to a NOx emission level monitoring method and device for an electronic-control diesel engine EGR (exhaust gas recirculation) system. The monitoring method comprises the steps of setting EGR valve position sensor, other sensors, an EGR valve, an engine management module, an EGR opening conversion module, an EGR valve blocking state recognition state and an NOx emission level monitoring module device, and presetting a voltage of the ERG valve position sensor corresponding to the opening of 0% and opening valve values I, II, III and IV; detecting control signals and target opening of the EGR valve by the engine management module; obtaining actually-detected opening corresponding to the position sensor by the calculus of interpolation of the EGR valve blocking state recognition module; judging the blocking state of the ERG valve by the ERG blocking state recognition module according to the actually-detected opening and the target opening; and judging a NOx emission level by the NOx emission level monitoring module according to the actual-detected opening and the blocking state of the EGR valve by adopting a hysteresis algorithm. The method and the device directlyadopt the EGR valve position sensor as a NOx emission level signal source without the need of a NOx senosr, thus saving the cost.

The invention discloses an EOG (Electrooculography)-based ERG (Electroretinography) signal acquisition and processing system and method. The system comprises a control unit, a retinal stimulator unit, an ERG signal acquisition unit and an ERG signal processing unit. The method comprises the following steps: adjusting illumination and flash rate of a stimulation light source; arranging three skin electrodes on the forehead just above eyes of a subject, on the inner sides of the eyes and the bridge of a nose and at eyelids respectively; performing dark adaptation for more than 20 minutes; aligning the eyes of the subject to the stimulation light source; acquiring an EOG signal; performing light stimulation on the eyes of the subject, synchronously acquiring the ERG signals on the inner sides of the eyes and the bridge of the nose and at the eyelids of the subject respectively, and storing after signal conditioning and AD (Analog-Digital) conversion; reading the ERG signals by an ERG signal processing and analysis unit and processing and analyzing the ERG signal. The ERG signals are acquired by using the external skin electrodes, so that the acquisition is more convenient and safer, and the cost is lower; for signal processing, the adopted method is small in operation and high in feasibility and can realize rapid signal processing.

Methods for the diagnosis, prognosis, patient stratification and prediction of pharmacological response in patients afflicted by psychiatric disorders based on electroretinography (ERG) parameters are described.

To provide an electrophotographic photoconductor that comprises a support and a cross-linked layer formed over the support, wherein the cross-linked layer comprises at least light curable of radically polymerizable compound, the difference of maximum value of the post-exposure electrical potential and minimum value of the post-exposure electrical potential when writing is conducted under the condition that image static power is 0.53 mW, exposure energy is 4.0 erg / cm2 for the electrophotographic photoconductor is within 30V.

The invention belongs to the immunology field and relates to three groups of primer pairs and probes and a kit for early diagnosis of the PC. The three groups of the primer pairs are provided with nucleotide sequences shown by SEQ ID NO: 1and SEQ ID NO: 4, SEQ ID NO: 2 and SEQ ID NO: 5 and SEQ ID NO: 3 and SEQ ID NO: 6 respectively. Three DNA probes are marked with biotin at 3' ends and are provided with nucleotide sequences shown by SEQ ID NO: 7, SEQ ID NO: 8 and SEQ ID NO: 9, and luminophore is connected on amino acid radicals at * positions in the sequences. The kit for early diagnosis of the PC is provided with the three groups of the primer pairs, reverse transcriptase and RNA polymerase and streptavidin coated on the RNA polymerase, and solid phase carriers of the DNA probes are connected onto the streptavidin. According to primer pairs, probes and the kit for early diagnosis of the PC, expression levels of human body TMP RSS2: ERG, PCA3 and PSA genes to judge risks of the PC through transcription-mediated amplification techniques.

This document provides methods and materials related to assessing prostate cancer in mammals. For example, methods and materials for using ERG expression levels and TOP2A expression levels to identify mammals (e.g., male human patients) as being susceptible to a poor prostate cancer outcome are provided.

A toner composition includes resin core particles having outer surfaces, and surface treatment, wherein the surface treatment includes at least first metal oxide particles having a surface area equivalent average particle diameter of greater than 25 nm and a surface energy of less than 28 erg / cm2, as determined by methanol wettability midpoint at 22° C., tacked to the outer surfaces of the resin core particles, at a concentration to provide a total projected area of the first metal oxide particles sufficient to cover at least 10% of the resin core particle outer surfaces area, and wherein the toner composition comprises less than 0.013 g non-tacked surface treatment per square meter of resin core particles outer surface. A developer for developing electrostatic images includes magnetic carrier particles and toner as described above, wherein the developer comprises less than 0.013 g non-tacked surface treatment per square meter of resin core particles outer surface, that is free to transfer between the outer surface of the resin core particles and outer surfaces of the magnetic carrier particles.

A method and device for optically stimulating the visual system during static perimetry and for objectively evaluating adequate stimulus-related electrophysiological and / or magnetophysiological quantities. Light stimuli with defined parameters derived from a predetermined correlation function and from the known intensity dependence of the excitation response amplitude are presented to the observer. The excitation responses contained in the ERG and / or in the EEG / MEG are detected and processed. These excitation responses are used to determine and topographically evaluate the local sensitivity of the visual system. In one embodiment, the light sources are fixed inside a perimeter, and the excitation responses are amplified and digitized by a device, which preferably comprises an ERG / EEG measuring system and an A / D converter. To this end, the device, for the purpose of evaluating, and the light sources, for the purpose of controlling, are connected to a controlling means, preferably to a PC provided with evaluation and control software.

There is provided a magneto-optic recording medium which suits the DWDD readout method and enables stable formation of domains even when ultramicromarks are recorded. The magneto-optic recording medium has a memory layer and a switching layer as magnetic films and, when produced, conditions for forming the magnetic films are so surveyed that the product of saturation magnetization Ms and coercive force Hc, MsHc, is maximized. An MsHc (106 erg / cc) of the memory layer is 15.8 (T / Tc-1) or more where temperature is represented by T (K) and Curie temperature of the memory layer by Tc (K).

The invention relates to an application of a GMFB antibody, in particular, an application of the GMFB antibody in the preparation of drugs for treating diabetic retinopathy. The GMFB antibody is injected into the right eye of an STZ induced DM rat by a vitreous cavity injection technology, then PBS with an equal amount is injected into the left eye, after two weeks, the difference of visual functions of two eyes of the rat is detected by an ERG method, and the result shows that the visual function of the eyeball that is injected with the GMFB antibody is obviously improved, compared with thatof the eyeball that is not injected with the GMFB antibody. Then people find that the GFAP expression of the retina of the eyeball with the GMFB antibody is prominently reduced, TUNEL dyeing for detecting cell apoptosis is also weakened, and the result shows that the GMFB antibody injected into the vitreous cavity can be used as a target of DR early intervention to protect the visual function.

A stimulus light from a stimulus light source is projected to the retina of an ocular fundus under examination to stimulate the retina in localized fashion to generate a bioelectric signal from the retina. The stimulus light source is mounted on a movable block, and an operating lever is used to move the stimulus light source to change the stimulus light on the retina. The size of the stimulus light can also be varied using a panel having a plurality of openings with different diameters for allowing the stimulus light to pass through. This assures a reliable local ERG examination because the bioelectrical signal can be produced in a wider area of the retina. The operating lever is further fixed by inserting a cap to keep the projected stimulus light unchanged. This allows the burden on the examiner to be reduced remarkably, assuring a reliable local ERG examination.

The invention belongs to the field of biological medicines, and discloses a composition for promoting hair cell regeneration and hearing recovery and an application thereof. The composition comprisesa Wnt agonist and one or more of the following reagents: (a) a VEGFR inhibitor; (b) a Tgfbr inhibitor; and (c) an ERG inhibitor. The VEGFR inhibitor comprises regorafenib, apatinib mesylate, cabozantinib, pazopanib hydrochloride and medicinal salts or derivatives of the regorafenib, the apatinib mesylate, the cabozantinib and the pazopanib hydrochloride. An organoid platform verifies that after any inhibitor in a signal axis of EGFR-TGFB1-ERG is combined with the Wnt agonist to prepare the composition, efficient hair cell differentiation, maturation and survival can be realized, and the composition has important value for hearing recovery.

The invention belongs to the technical field of information storage, and relates to a high-density low-cost magnetic recording medium FeNi alloy and a preparation method therefor. The alloy is in a multilayer film structure, and is characterized in that an FeNi film takes (001) MgO as substrate, takes Fe as a seed layer, and takes Au as a buffering layer; a film with (001) orientation is grown and prepared in a mode of molecular beam epitaxy; the alloy has an L10 order structure, and meets the requirements of the application of a super-high density magnetic recording medium. According to the invention, the magnetocrystalline anisotropy parameter Ku can reach 2.3*10<7> erg / cc. The method reduces the material cost under the condition of obtaining high magnetocrystalline anisotropy parameters, and increases the saturation magnetization intensity of an alloy film.

The invention provides a signal amplifier for a portable detection system of the electroretinogram (ERG). The signal amplifier comprises two gain adjusting knobs, a built-in signal amplification circuit, two measuring electrode magnetic interfaces, a reference electrode, as well as a common reference electrode interface, two measuring electrodes and two output plugs, wherein the two measuring electrode magnetic interfaces are arranged at the input end of the signal amplifier, the reference electrode is connected to the signal amplifier through one reference electrode magnetic interface, the main body part of the signal amplifier is J-shaped, the end, connected with the measuring electrodes, of the main body part of the signal amplifier is bent, due to the adoption of the novel design, the measuring accuracy and simplicity are greatly improved, and the cost is also extremely low.

The invention provides an active electrode detection device for an electroretinogram and an electro-oculogram. The device comprises a miniature front signal amplifier, a ground electrode, an ERG electrode, an EOG electrode and a reference electrode, the ground electrode, the ERG electrode, the EOG electrode and the reference electrode are connected with the miniature front signal amplifier, the reference electrode is arranged on one side of the miniature front signal amplifier, the ERG electrode and the EOG electrode use the same universal reference electrode, and the reference electrode is attached to the surface of human face skin. According to the device, a short connecting wire between a sensor and the amplifier is provided with a short transmission line, so that most external noise and interference can be eliminated; by means of the design, signals can have high signal-to-noise ratio, high reproducibility, high common-mode rejection ratio and high sensibility to low stimulation, and the electrodes can be made into disposable electrodes, so that infection is prevented, which is beneficial to patients and doctors, and infection control standards of a hospital are met.

The present invention relates to peptide and polynucleotide fragments of ERG-1, and in particular, human ERG-1a (HERG-1a) and its isoforms, and their use in the treatment and diagnosis of disease, especially cardiac diseases, such as arrhythmias, and cancer.

Apparatus for evoking and sensing ophthalmic physiological signals in an eye, the apparatus comprising: an elongated tubular light pipe having a longitudinal axis, a distal end and a proximal end, the distal end terminating in a spheroid recess; an active electrode having a distal end and a proximal end, the active electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the active electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; and a reference electrode having a distal end and a proximal end, the reference electrode being mounted to the elongated tubular light pipe and extending proximally along the elongated tubular light pipe so that the distal end of the reference electrode terminates at the spheroid recess at the distal end of the elongated tubular light pipe; wherein the distal end of the active electrode is located closer to the longitudinal axis of the elongated tubular light pipe than the distal end of the reference electrode.

An ocular light stimulus apparatus is proposed in which an ocular fundus of an examinee's eye is illuminated by infrared light from an illumination light source via a ring slit disposed in the position conjugate with the anterior ocular segment thereof, and the ocular fundus is irradiated with stimulus light from a stimulus light source and background light from a background light source via a photographic stop disposed in the position substantially conjugate with the anterior ocular segment of the examinee's eye. This allows the background light to be projected onto the ocular fundus so as to spread in all directions about the center of the anterior ocular segment. Therefore, the entire ocular fundus can be uniformly illuminated about the position onto which the stimulus light is projected, and an accurate local ERG examination can be performed. Since the ocular fundus is irradiated with the background light and the stimulus light via the center part of the pupil, shading does not occur even when the pupil diameter is somewhat small, and the amount of the background light and the stimulus light can be kept constant regardless of the pupil diameter, ensuring a highly reliable local ERG examination.

The invention discloses an EGR (Exhaust Gas Recirculation) mixer of a dual-gas pickup structure. The ERG mixer is characterized by comprising a mixer housing and a mixer core, wherein a first exhaust gas inlet and a second exhaust gas inlet are formed in the sidewalls of the mixer housing, the mixer core is fixedly mounted in the mixer housing, a cavity is formed between the mixer core and the mixer housing and communicated with the first exhaust gas inlet and the second exhaust gas inlet, the mixer core is a venturi tube, a plurality of deflector holes are formed in the throat opening of the venturi tube so that the exhaust gas is capable of going into the mixer core, a fresh air inlet is formed at one end of the mixer core, and the exhaust gas is mixed with the fresh air in the mixer core and then the mixed gas is output via an outlet at the other end of the mixer core to supply gas to an engine. The ERG mixer of the dual-gas pickup structure is characterized in that two independent exhaust gas inlets are provided to realize dual-gas pickup and also can be applied for a sectional exhaust pipe to pick up gas independently, the venturi tube type mixer core is used for improving the mixing effect and effectively solving the problem that the EGR rate cannot be increased when gas is exhausted at a low speed.

A flexible loop electrode for electroretinographic (ERG) recordings of extra-corneal signals with a protective bead and a U-shaped electrode form that is particularly adapted for use with spectacles or a fixed mount. Means also employed to detect electrode integrity.

In some embodiments, a system for providing a therapeutic treatment to a patient's eye includes a treatment beam source configured to transmit a treatment beam along a treatment beam path. The system further includes a processor coupled to the treatment beam source, the processor being configured to direct the treatment beam onto retinal tissue of the patient's eye and deliver a series of short duration pulses from the treatment beam onto the retinal tissue at a first treatment spot to treat the retinal tissue. In some embodiments, a pre-treatment evaluation method using electroretinography (ERG) data may be used to predict effects of treatment beams at different power values and to determine optimal power values.