11875 results about "Amide" patented technology

The present application relates to the technical field of medicines, and relates to a macrocyclic compound containing amide substitution, in particular to a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, and a preparation method therefor, a pharmaceutical composition containing the compound, and a use thereof in the treatment of disease.

The invention relates to the technical field of oil exploitation, and discloses a compound containing an amide group as well as a preparation method and application thereof. The compound containing the amide group has a structure as shown in a formula (1). The polymer obtained by polymerizing the compound can improve the water-drive recovery efficiency of conventional oil reservoirs and common heavy oil reservoirs. # imgabs0 #

The invention relates to the technical field of electronic devices, in particular to a monomolecular electric memristor based on dipole control and a preparation method thereof.The monomolecular electric memristor comprises a molecular heterojunction, and the molecular heterojunction is formed by connecting dipole molecules and graphene point electrodes through amido bonds; the dipole molecule comprises an amide structure based on a carbazole nitrogen-containing heterocyclic ring unit, under the action of an external electric field, a side chain chemical bond of the dipole molecule can rapidly rotate, the size and direction of an intramolecular dipole moment can be changed, the molecule can be rapidly and stably switched among different resistance states, and the read-write speed of the memristor is remarkably improved; the storage state is stably kept under the power-off condition, and the long-term stability and reliability of the memristor function are ensured. The preparation method comprises the processes of introducing dipole molecules and forming amido bonds between the dipole molecules and the graphene point electrode, and the preparation method is simple and convenient to operate, mild in condition and beneficial to large-scale production.

An absorbent retail paper product comprised of cellulosic fibers having a concentration of 1, 3-dichloro-2-propanol that is not detected to 50 ppb, as measured using the ACOC official method 2000.0150, a concentration of 3-monochloro-1, 2-propanediol that is not detected to 1000 ppb, as measured using the ACOC official method 2000.0150, as measured by the "adipic acid test", as measured by the ACOC official method 2000.0150, as measured by the ACOC official method 2000.0150, as measured by the ACOC official method 2000.0150, as measured by the ACOC official method 2000.0150, as measured by the ACOC official method 2000.0150, as measured by the ACOC official method 2000.0150. Polyaminoamide-epihalohydrin at a concentration of not detected to 0.09% has a lateral wet strength of from 80 n / m to 200 n / m wherein all of the cellulosic fibers contained in the absorbent paper product are non-synthetic, the cellulosic fibers and the absorbent paper product are substantially free of formaldehyde.

The present invention addresses the problem of providing a pneumatic tire in which a reduction in tire performance is mitigated despite using polyamide fibers with low amide density. The solution is a pneumatic tire characterized by comprising a carcass layer (50), belt layers (60A, 60B), and a belt reinforcement layer (70A), wherein reinforcing cords (50-1, 70A-1) in the carcass layer (50) and / or the belt reinforcement layer (70A) contains polyamide fibers having an amide density of 14.0 or less, and (i) when a gauge thickness A from the outer circumferential surface on the tire inner-surface side of the reinforcing cords (50-1) of the carcass layer (50) to the tire inner surface is measured at 100 equally spaced points, the average of the gauge thickness A is 1.5 mm or less, or (ii) when a gauge thickness D from the outer circumferential surface on the tire outer-surface side of the reinforcing cords (70A-1) of the belt reinforcement layer (70A) to the tire outer surface is measured at 100 equally spaced points, the gauge thickness D is 6.0 mm or less at 80% of the measurement points or more.

The invention discloses a high-bonding-strength flame-retardant composite current collector base film and a preparation method thereof. The high-bonding-strength flame-retardant composite current collector base film is prepared from the following raw materials in parts by weight: 100 parts of PP resin, 1.5 parts of a lubricant, 0.8 part of an antioxidant and 16 parts of reinforced flame-retardant composite particles, the reinforced flame-retardant composite particles are prepared by the following steps: S1, preparing amidated porous carbon microspheres; s2, compounding the amidated porous carbon microspheres with mica powder to prepare a composite carrier; s3, loading a flame retardant to prepare a flame-retardant compound; s4, in-situ grafting of maleic anhydride grafted polypropylene is carried out, and the reinforced flame-retardant composite particles are obtained. By adding the reinforced flame-retardant composite particles into the PP resin, the flame retardance and mechanical strength of the PP-based composite current collector base film and the interface bonding force between the PP base film and the metal conductive layer can be comprehensively improved.

The invention relates to the technical field of batteries, in particular to a solid electrolyte material and a preparation method thereof, a solid electrolyte membrane and a battery. The solid electrolyte material has a core-shell structure, the core-shell structure comprises an inner core and a coating layer arranged on the surface of the inner core, the inner core comprises a sulfide electrolyte, and the coating layer comprises an amide compound. According to the solid electrolyte material disclosed by the invention, the coating layer containing the amide compound is arranged on the surface of the sulfide electrolyte, so that the air stability of the solid electrolyte material can be effectively improved, and meanwhile, the solid electrolyte material is ensured to have proper conductivity without influencing the charge-discharge performance of a battery.

The invention discloses an N-cyclobutyl substituted benzamide isoxazoline compound as well as a preparation method and application thereof. The N-cyclobutyl substituted benzamide isoxazoline compound has broad-spectrum and efficient insecticidal activity at a low dosage, and has a remarkable effect on prevention and treatment of diseases and insect pests in agriculture and forestry and pests in the field of sanitation; moreover, the pesticide composition is safer to non-target organisms, can reduce the damage to plants, non-target organisms and human beings due to overhigh pesticide concentration, and is more beneficial to crop protection and environmental safety.

The invention relates to the technical field of low-carbon olefin hydration, and discloses a modified hydrated filler as well as a preparation method and application thereof. The modified hydrated filler comprises a filler matrix, and a silane layer, a modified layer A and a modified layer B which are sequentially coated on the outer surface of the filler matrix from inside to outside, the modified layer A contains a pyrrolyl group, an amido group and a furyl group; the modified layer B contains phenoxy, pyrrolyl, furyl, sulfonic acid group, phosphate group and acylamino. The modified hydrated filler provided by the invention can obviously improve the mixing effect of water and alkene and promote the improvement of the yield of low-carbon alcohol.

The invention discloses a preparation method of a high-dispersion and high-thermal-conductivity filler based on carbon black, and relates to the technical field of carbon black modification, and the preparation method specifically comprises the following steps: treating carbon black in a first acid solution to obtain activated carbon black; treating the single-walled carbon nanotube in a second acid solution to obtain an activated single-walled carbon nanotube; treating the activated single-walled carbon nanotube with a sulfanilamide solution to obtain a functionalized single-walled carbon nanotube; placing the graphene nanosheets in a third acid solution for treatment to obtain activated graphene nanosheets; the preparation method comprises the following steps: mixing amino silane hydrolysate and epoxy silane hydrolysate, adding activated carbon black, functionalized single-walled carbon nanotubes and activated graphene nanosheets, and treating to obtain a pre-modified filler; amino acid and a cross-linking agent are pre-polymerized to obtain an amino acid pre-polymerized solution, and the pre-modified filler is treated by the amino acid pre-polymerized solution to obtain the high-dispersion and high-thermal-conductivity filler. The method disclosed by the invention is simple to operate and low in energy consumption, the prepared filler is good in thermal conductivity and good in dispersity in a polymer matrix, and the thermal conductivity and the mechanical property of a polymer are greatly improved.

The invention belongs to the technical field of biomedical materials, and particularly relates to adipose-derived mesenchymal stem cell loaded conductive hydrogel and a preparation method and application thereof, the preparation method comprises the following steps: step S1, after hyaluronic acid is subjected to oxidation treatment, dopamine is grafted to oxidized hyaluronic acid, and oxidized hyaluronic acid-dopamine is obtained; step S2, carrying out amination treatment on gelatin to obtain aminated gelatin; s3, mixing the oxidized hyaluronic acid-dopamine with the aminated gelatin, and carrying out Schiff base crosslinking, so as to obtain hydrogel; and step S4, loading the adipose tissue-derived stromal cells by using the hydrogel. Dopamine is grafted on an oxidized hyaluronic acid macromolecular chain through amidation reaction, the hydrophilicity and the electrical property of the macromolecular chain are improved, a catechol structure is provided to provide possibility for iron ion coordination, the tissue adhesion, the injectability, the mechanical property and the electrical conductivity of the hydrogel are improved, and the hydrogel can be applied to the field of biomedical materials. After being applied to a spinal cord injury rat model, the functional recovery can be promoted.

The invention discloses an environment-friendly slow release fertilizer and a preparation method thereof, and belongs to the technical field of fertilizer mixture preparation. The preparation method comprises the following steps: mixing and stirring a mussel extract-polysaccharide-nitrogen fertilizer complex, an inorganic fertilizer and water according to a weight part ratio of (1-2): (5-7): (15-23), heating to 50-60 DEG C to form a dispersion solution, mixing and stirring the dispersion solution and a calcium salt according to a weight part ratio of 1: (0.005-0.01), cooling to 20-25 DEG C, and reacting for 20-24 hours to obtain a viscous mixture; and drying, dewatering and crushing the viscous mixture to obtain the environment-friendly slow-release fertilizer. According to the environment-friendly slow-release fertilizer, the mussel extract with a good adhesion effect and the carboxymethyl cellulose or the hyaluronic acid with biocompatibility are used as carriers, through the synergistic cooperation of an amide structure, an imine structure and metal coordination, wrapping of a nitrogen fertilizer and an inorganic fertilizer is achieved, and finally the environment-friendly slow-release fertilizer is obtained.

The invention belongs to the technical field of organic matter preparation, and discloses an amide-containing isoxazoline derivative as well as a preparation method and application thereof. According to the invention, chemical modification and molecular design are carried out on the compound with an isoxazoline structure, and a substituent group is introduced to N of an amide group, so that a series of efficient compounds which can be used for killing insects or mites in agriculture or forestry and have excellent activity are obtained, and particularly, the compounds have very good biological activity on lepidoptera, hemiptera and other pests. When being used at an extremely low concentration, the compound disclosed by the invention also shows an excellent control effect on various pests or pest mites, has insecticidal or acaricidal activity in each stage (such as eggs, larvae (nymphs), pupae and adults) of the life cycle of the pests or pest mites, and has an excellent control effect on the pests or pest mites which have drug resistance to traditional insecticides or acaricides. And the composition also shows excellent control activity.

The invention relates to the technical field of thickening agents, and discloses a preparation method of a high-temperature-resistant thickening agent for fracturing. According to the preparation method disclosed by the invention, acrylamide, sulfobetaine modified acrylamide and pyrrolidone modified naphthyl melamine are polymerized, so that the thickening agent for high-temperature-resistant fracturing is obtained. A triazine ring structure and naphthyl have high stability, the rigidity of a polyacrylamide molecular chain and the hydrophobic association effect between molecules are enhanced, the high temperature resistance and the salt resistance are improved, and due to the conjugation effect formed by two benzene rings in naphthyl, the thermal stability is further enhanced; by introducing vinyl pyrrolidone, hydrolysis of amido in polyacrylamide can be inhibited, and the temperature resistance and salt resistance of the thickening agent are improved; under a high-salt condition, due to weakening and shielding of mutual attraction of salt ions to anionic and cationic groups in the sulfobetaine, polyacrylamide molecules are more stretched, macroscopically, the viscosity is increased or reduced slightly, and the temperature resistance and salt resistance are improved.

The present disclosure relates to the technical field of drilling fluid, and discloses a high density environmentally friendly polymer water-based drilling fluid with resistance to 240° C. and saturated salts, a preparation method therefor and use thereof. The water-based drilling fluid comprises a micro-crosslinked heterocyclic polymer filtrate reducer, a hyper-branched strongly adsorbed filtrate reducer, a nanometer intercalated complex shearing potentiator, a flexible outer and rigid inner microsphere plugging agent, and water, wherein the micro-crosslinked heterocyclic polymer filtrate reducer is prepared by reacting sodium p-styrene sulfonate, N,N,N-trimethyl-3-(2-methylallylamino)-1-propyl ammonium chloride, N,N-diethyl acrylamide, N-vinyl caprolactam, tetramethyl ethylenediamine with phenyl triethoxy silane. The high density environmentally friendly polymer water-based drilling fluid with resistance to 240° C. and saturated salts of the present disclosure can exhibit good performance at high temperature and high salinity conditions, and has desirable weighting capability, it can meet the requirements of drilling well in the deep oil and gas formations.

The invention discloses a high-performance composite solvent-resistant nanofiltration membrane with a rigid twisted non-planar structure polyamide layer and a preparation method of the high-performance composite solvent-resistant nanofiltration membrane. The preparation method comprises the steps of preparation of the rigid twisted non-planar structure polyamide layer and surface modification. A water phase solution containing adamantane diamine and m-phenylenediamine and an organic phase solution containing 1, 3, 5-trimesoyl chloride and acetone are subjected to interfacial polymerization reaction to prepare a polyamide layer with a rigid twisted non-planar structure, and then a polyphenol modifier is used for carrying out hydrophilic modification on the polyamide layer, so that the rigid twisted non-planar structure is obtained. The pure water permeability and retention rate of the solvent-resistant nanofiltration membrane are obviously improved; due to the introduction of adamantane diamine, the interfacial polymerization process and the formation of a polyamide layer are remarkably regulated and controlled, and the separation performance of the solvent-resistant membrane is greatly improved on the premise that the interception performance of the membrane is hardly reduced; the preparation process is simple, and the prepared membrane is excellent in performance and has a good application prospect in the aspect of organic solvent separation.

The invention relates to a full-temperature-range polymer-based solid electrolyte, a solid-state battery and a preparation method. Mixing alkali metal salt, a polymer monomer and a plasticizer to obtain an electrolyte precursor; the polymer monomer comprises a fluorinated acrylate compound; the plasticizer comprises a fluorinated carboxylic ester compound, a fluorinated carbonic ester compound or a fluorinated amide compound; and adding an initiator into the electrolyte precursor, heating and polymerizing to obtain the polymer-based solid electrolyte with the polar functional group forming the dipole group, namely the full-temperature-range polymer-based solid electrolyte. A polymer monomer with a soft long side chain is used, and plasticizer molecules are anchored between polymer chains, so that leakage of the plasticizer molecules and parasitic reaction between the plasticizer molecules and an electrode are reduced, and the interface stability of the electrolyte in a high-temperature environment is improved; a polar functional group in the solid electrolyte has relatively high electronegativity, and the formed dipole interacts with alkali metal ions, so that the ions are quickly decoupled from a polymer matrix, and the low-temperature conductivity is favorably improved.

The invention discloses a composite solid electrolyte membrane, a solid lithium metal battery and a preparation method thereof, the composite solid electrolyte membrane comprises a fast ion conductor filler, a PVDF polymer matrix, a lithium salt and an amide additive, and the amide additive can perform weak coordination with lithium ions. According to the composite solid-state electrolyte membrane, the solid-state lithium metal battery and the preparation method of the solid-state lithium metal battery, disclosed by the invention, the room-temperature ionic conductivity of all-solid-state composite electrolyte can meet room-temperature operation of the battery, and the solid-state lithium metal battery is suitable for large-scale production and application.

The invention belongs to the technical field of pharmaceutical chemical processes, and particularly relates to a preparation method of a penem antibiotic intermediate 4-BMA, which comprises the following steps: adding Zn powder, chlorosilane, aliphatic tertiary amine, zinc salt and 4-AA in a formula (I) into THF (tetrahydrofuran), uniformly stirring, dropwise adding a THF solution of alpha-haloamide with an induction group in a formula (II) for reaction, filtering the reaction solution, removing the zinc powder, and drying to obtain the penem antibiotic intermediate 4-BMA. Extracting the filtrate to obtain a THF phase, washing with an aqueous solution of potassium oxalate, and recovering THF to obtain a formula (III); and carrying out oxidative hydrolysis, sulfur dioxide quenching, sulfur dioxide acid regulation crystallization and recrystallization on the formula (III) to obtain the intermediate 4-BMA. According to the preparation method disclosed by the invention, a zinc salt is used as a catalyst during preparation of the formula (III), potassium oxalate is used for removing residual Zn (II) in a THF phase, SO2 is used for quenching hydrogen peroxide and acid regulation and crystallization of 4-BMA, the oxygenolysis problem of 4-BMA is solved, and the preparation method has the characteristics of greenness, safety and high efficiency, is strong in product competitive advantage and is suitable for industrial production.

The invention belongs to the technical field of civil engineering materials, and provides an early-strength high-fluidity geopolymer grouting material and a preparation method thereof. The method comprises the following steps: firstly, carrying out heat treatment and chemical regulation on fly ash and granulated blast furnace slag to generate a pre-reaction phase with high reaction activity, and improving the alkali excitation reaction efficiency; then, by preparing a lubricating particle dispersion liquid and utilizing the synergistic effect of a silane coupling agent and interface lubricating particles, the uniform dispersity of the particles is enhanced; by adding the ionic liquid and the functionalized acylamino polymer, the dissolution and activation of the aluminosilicate are accelerated by utilizing the high polarity, the ion shielding effect and the dissolution enhancing performance of the ionic liquid; meanwhile, the amido polymer inhibits particle aggregation and stabilizes the particle dispersion state through the adsorption effect, the amido polymer and the amido polymer cooperate to form a lubricating layer in the slurry, reduce the viscosity of the slurry and improve the fluidity, and the early strength of the material is further improved by accelerating the generation of a gel phase.

The invention discloses an anti-scale cross-linked polymer fracturing fluid and a preparation method thereof, and relates to the technical field of petroleum fracturing fluids. When the anti-scale cross-linked polymer fracturing fluid is prepared, allylamine hydrochloride and epoxy chloropropane react to prepare a double-bond chlorinated intermediate; reacting the double-bond chlorinated intermediate with lauramidopropyl dimethylamine to prepare a cationic monomer; copolymerizing a cationic monomer and acrylamide to prepare a cationic polymer; the preparation method comprises the following steps: reacting L-lysine with formaldehyde and phosphorous acid to prepare phosphoric acid modified lysine; reacting the phosphoric acid modified lysine with allyl glycidyl ether to prepare a phosphoric acid modified monomer; acrylamide and an anionic monomer are copolymerized to prepare an anionic polymer; the anionic polymer and the cationic polymer are dissolved in water to prepare the anti-scale cross-linked polymer fracturing fluid. The anti-scale cross-linked polymer fracturing fluid prepared by the invention has the advantages of scale prevention, good temperature resistance, good shear resistance and self-crosslinking.

The invention belongs to the field of skin care products, and particularly relates to an anti-wrinkle and anti-aging composition as well as a preparation method and application thereof, and the anti-wrinkle and anti-aging composition comprises neurotransmitter inhibition peptide, signal peptide, madecassoside, inositol and glycosylglycerol. The neurotransmitter inhibition type peptide is at least three of acetyl hexapeptide-8, arginine / lysine polypeptide, dipeptide diaminobutyrylbenzylamide diacetate and acetyl octapeptide-3, and the signal type peptide is at least two of palmitoyl pentapeptide-4, decapeptide-4 and acetyl tetrapeptide-9. Compared with the prior art, all the components of the anti-wrinkle and anti-aging composition act on different anti-aging pathways and can be matched with one another from multiple aspects of oxidation resistance, inflammation resistance, moisturizing, cell viability enhancement, wrinkle reduction and the like, a more comprehensive and better anti-aging effect is provided, skin aging is comprehensively resisted, the skin is in a more young state, and the anti-wrinkle and anti-aging composition has the advantages that the anti-wrinkle and anti-aging effects are achieved. And the anti-wrinkle and anti-aging composition is small in irritation and good in stability.

The invention relates to the technical field of chemical synthesis, and particularly provides a preparation method of a semaglutide side chain, which comprises the following steps: step S1, carrying out reaction on octadecanedioic acid mono-tert-butyl ester and trifluoroacetic acid pentafluorophenyl ester to generate a first intermediate; s2, enabling the first intermediate to react with 1-tert-butyl L-glutamic acid to generate a second intermediate; s3, enabling the second intermediate to react with pentafluorophenyl trifluoroacetate to generate a third intermediate; and S4, carrying out an amidation reaction on the third intermediate and 17-amino-10-oxo-3, 6, 12, 15-tetraoxa-9-aza-heptadecanoic acid, so as to generate a semaglutide side chain, and carrying out an amidation reaction on the third intermediate and 17-amino-10-oxo-3, 6, 12, 15-tetraoxa-9-aza-heptadecanoic acid. According to the preparation method disclosed by the embodiment of the invention, the pentafluorophenyl trifluoroacetate is used as the condensation reagent for two times to activate the carboxylic acid, and the amidation reaction is carried out for two times to construct the amido bond after each activation, so that compared with the traditional carbodiimide and urea positive ion type condensation reagent, the chiral racemization in the condensation process can be effectively avoided, and the yield of the product is improved. The condensation chiral racemization impurity can be lower than 0.3%.

The invention belongs to the technical field of organic chemical synthesis, and particularly relates to a gentiopicroside amide derivative, a synthesis method and application. A series of gentiopicroside amide derivatives are synthesized by taking gentiopicroside as a research object, carrying out structural modification on 6 '-site hydroxyl of gentiopicroside and introducing a benzoyl chloride group into a gentiopicroside structure. The synthetic method has the beneficial effects that on one hand, the synthetic method of the gentiopicroside amide derivative, which is mild in reaction condition and environment-friendly, is established; on the other hand, the 20 synthesized gentiopicroside amide derivatives have a remarkable inhibition effect on expression of LPS-induced THP-1 macrophage IL-6 and STAT3 protein content, the anti-inflammatory activity is remarkable, the action effect is superior to that of parent compound gentiopicroside, and a new thought is provided for preparation of STAT3 small-molecule inhibitors and anti-inflammatory drugs.

The invention discloses a production process of antistatic polyamide fiber, and relates to the technical field of textile chemical fiber production, the antistatic polyamide fiber comprises the following raw materials by weight: 30-40 parts of polyethylene glycol terephthalate, 60-70 parts of polyamide, and 3.6-4.8 parts of master batch. The master batch is prepared from the following raw materials in parts by weight: 80 to 90 parts of polyamide, 2 to 4 parts of an antistatic agent, 0.7 to 0.9 part of an anti-ultraviolet agent, 0.7 to 0.9 part of an auxiliary agent, 2.5 to 3.5 parts of a toughening agent and 0.5 to 0.7 part of a dispersing agent. The synthesized antistatic agent contains carbon fibers, a polyether structure, an amide structure and a DOPO structure, so that the antistatic property and flame retardance of the antistatic polyamide fiber are improved. The synthesized anti-ultraviolet agent contains a benzimidazole structure, a sulfydryl ester structure, a hindered phenol structure and an amide structure, so that the ultraviolet aging resistance of the antistatic polyamide fiber is improved.

A photobase generator includes a compound including: first skeletons represented by the following formula (a); and a second skeleton including nitrogen atoms bonding to bonding positions of the first skeletons to form amide groups, wherein, in a molecule, a number of the first skeletons is two or more, a number of the nitrogen atoms, configuring the amide groups, in the second skeleton is the same as the number of the first skeletons, and at least one of the nitrogen atoms configuring the amide groups is converted into a nitrogen atom configuring a secondary amine or a tertiary amine by light irradiation. In the formula (a), G is a divalent aromatic group, and * represents the bonding position with the nitrogen atom.

The invention provides a solid electrolyte film and a preparation method thereof, a diaphragm-free solid-state battery, a solid-state battery and a mechanical device. The method comprises the following steps: (1) mixing and modifying a lithium salt, an ionic liquid and a cross-linking agent to obtain a modified active component; (2) mixing the modified active component, a polymer monomer and an initiator to obtain a precursor solution, wherein the polymer monomer comprises at least one of a boron-containing monomer, a sulfate monomer, a carbonate monomer, an amide monomer, an ether monomer and a fluorine-containing monomer; and (3) applying the precursor solution to a base material for polymerization to obtain the solid electrolyte film. Therefore, the solid-state electrolyte film has high lithium ion conductivity and excellent mechanical strength and stability, a solid-state battery prepared from the solid-state electrolyte film has high ionic conductivity, a diaphragm can be replaced, a diaphragm-free battery can be prepared, the cycle life of the battery is prolonged, and the safety of the battery is improved.

The invention provides a liposome preparation and a preparation method thereof, the liposome preparation comprises an ion pairing agent, phospholipid or a derivative thereof, sterol, a lipid molecule derivative and a drug compound, the ion pairing agent comprises at least one of a compound (I) and a compound (II), and the compound (II) comprises at least one of a compound (III) and a compound (III). Structures in the compound (I) and the compound (II) contain a plurality of functional groups (such as amide, carbonyl, thioether and the like), so that abundant binding sites are provided for drug molecules, and the compound (I) and the compound (II) can interact with different types of drug compounds (such as fat-soluble and water-soluble drugs); the liposome preparation is allowed to be combined with various drug molecules through hydrogen bonds, hydrophobic interaction or electrostatic interaction, and the liposome preparation adapts to physicochemical properties of different drugs. The compound (I) and the compound (II) further comprise different hydrophobic groups (such as alkyl chains) and hydrophilic groups (such as sulfonic acid, carboxylic acid and the like), so that the liposome preparation has the amphiphilic characteristic, not only can encapsulate hydrophobic drugs, but also can encapsulate hydrophilic drugs, and the variety and range of encapsulated drugs are improved.

The invention discloses a full D-type antibacterial peptide with high enzymolysis stability and broad-spectrum antibacterial activity and application thereof. The antibacterial peptide is obtained by sequentially and repeatedly arranging D-type tryptophan, D-type arginine and D-type lysine for four times and carrying out C-terminal amidation; the amino acid sequence of the gene is (D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-NH2, and is marked as DWRK-12. The antibacterial peptide shows broad-spectrum antibacterial activity and excellent stability, can effectively resist clinically separated multidrug resistant strains, and keeps high cell selectivity at the same time. Due to the characteristics, the antibacterial peptide has important application value in the aspect of developing novel antibacterial drugs, especially in the field of treatment of infection of multiple drug-resistant bacteria.