1306 results about "Amide" patented technology

Disclosed herein is a compound that is (R)-(2-(3-((((2-ethylbutanoyl)oxy)methoxy)carbonyl)-2-hydroxyphenyl)-1-propionamidoethyl)boronic acid citrate coordination complex, or a pharmaceutically acceptable salt or solvate thereof. Also disclosed herein are methods of treating a bacterial with a compound that is (R)-(2-(3-((((2-ethylbutanoyl)oxy)methoxy)carbonyl)-2-hydroxyphenyl)-1-propionamidoethyl)boronic acid citrate coordination complex, or a pharmaceutically acceptable salt or solvate thereof in combination with ceftibuten.

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

The present invention relates to an extract of in vitro cultured C. sativa root tissues, characterized in that said extract comprises at least one lignanamide. The present invention also relates to a pharmaceutical, dermatological, nutraceutical, or cosmetic composition comprising, as an active ingredient, the extract described above.

The present specification relates to a composition including a new amide-based compound derived from an amino acid structure such as valine, leucine, phenylalanine, proline, pipecolic acid, or the like, wherein the composition exhibits a skin anti-aging or skin reverse-aging effect by restoring the size and number of dendrites of aged melanin-producing cells to those of young cells. As a result, the composition may exhibit a skin brightening effect by inhibiting the amount of melanin produced in the melanin-producing cells.

The present disclosure relates to a pharmaceutically acceptable salt (formula 1) and a crystal form of a 1,4-dihydro-1,6-naphthyridine amide compound, and a preparation method therefor. Specifically, provided in the present disclosure are a pharmaceutically acceptable salt and crystal form of (S)-4-(3-acetyl-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-4-yl)-3-(methoxy-d3)benzonitrile, and a preparation method therefor. The corresponding crystal form has good stability and can be better used for clinical treatment.

This invention provides a method for preparing and applying a highly insecticidal diamide compound, relating to the chemical and pesticide fields. The method includes: reacting 2-fluoro-3-nitrobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound A; condensing compound A with 2-trifluoromethyl-4-heptafluoroisopropyl-6-bromoaniline amide to obtain compound B; reducing compound B to obtain compound C; and, during the reaction under a hydrogen atmosphere, determining the reaction temperature and hydrogen flow rate in each hydrogenation reaction zone based on the concentration of compound B; reacting compound C with paraformaldehyde to obtain compound D; chlorinating 3-chloro-4-fluorobenzoic acid with thionyl chloride (a chlorinating agent) and dimethylformamide (a catalyst) to obtain compound E; and amide condensing compound E with compound D to obtain the novel diamide compound of this invention. The diamide compound of this invention exhibits excellent insecticidal effects when used in pesticide compositions.

This invention belongs to the field of material extraction technology, and relates to a method for preparing an extract of *Taxus wallichiana*, its product, and its application. The preparation method includes: mixing *Taxus wallichiana* with an aqueous two-phase system, extracting, allowing to stand and separate phases, collecting phase A and filtering to obtain a filtrate; treating the filtrate with an adsorbent and filtering to obtain the final product; the aqueous two-phase system includes phase A and phase B; phase A includes ethanol and behenamidopropyl dimethylamine; phase B includes inorganic salts and water. The *Taxus wallichiana* extract prepared by this invention does not contain four substances: taxine B, paclitaxel, 10-deacetylated paclitaxel, and cephalotaxine, and the extract has excellent antioxidant, soothing, moisturizing, and anti-aging effects.

This invention discloses a method for preparing a cyclic peptide compound containing a cisamide bioelectron isosteric cyclic peptide. The method involves introducing a thioamide unit at a specific position on the peptide backbone, making it a potential activatable reaction site. This site is selectively activated by a metal salt and undergoes an intramolecular condensation reaction with an acylhydrazine group located in the same peptide chain, generating a 1,2,4-triazole heterocyclic structure in situ. In a single reaction process, the cyclization of the peptide and the precise construction of the cisamide bioelectron isosteric group in the peptide backbone are achieved simultaneously.

The application discloses a dihydroquinazolinone-containing N-hydroxy amide compound and a preparation method and application thereof, relates to the technical field of medicinal chemistry, and utilizes the splicing principle to design and synthesize dihydroquinazolinone-containing N-hydroxy amide compounds with novel structures, and the compounds are tested in terms of HDAC6 protein affinity and anti-proliferation activity of cervical cancer cell Siha, and the results show that the compounds E1-E5 have better affinity to the HDAC6 protein, the IC 50 values are 4.1-85.4 nM, wherein the affinity of the compound E4 to the HDAC6 protein is higher than that of a positive control SAHA; and the compounds E1-E5 can better inhibit the proliferation of the cervical cancer cell Siha, the IC 50 values are 2.4-9.3 muM, wherein the activity of the compound E4 is the strongest.

Disclosed are a peptide amide compound composition, a preparation method therefor and medical use thereof. Specifically, the composition contains a compound of formula (I) and pH regulators, and the pH of the solution thereof is 3-5.5. The composition is stable and requires few excipients, and is stable in clinical use.

The present invention relates to a novel crystalline form of a helicase-primase inhibitor compound, and to pharmaceutical compositions comprising the novel crystalline form, to methods of production of the novel crystalline form, to the crystalline form in medicine and for use in the treatment of herpes viral infections.

The present application relates to the technical field of pesticide chemistry and medicinal chemistry, and particularly relates to a substituted pyrazole-containing ortho-hydroxy aryl formamide derivative, a preparation method and application thereof. The substituted pyrazole-containing ortho-hydroxy aryl formamide derivative is prepared from a 5-amino pyrazole intermediate (I) and a different substituted ortho-hydroxy aryl formic acid (II) as raw materials through an amide condensation reaction. The substituted pyrazole-containing ortho-hydroxy aryl formamide derivative prepared by the present application has a broad-spectrum inhibitory activity on plant pathogenic fungi, and particularly has excellent inhibitory activity on Valsa mali, Sclerotinia sclerotiorum and Botrytis cinerea, and is expected to be developed into a new type of green fungicide with high efficiency, safety, economy and environmental friendliness.

This application relates to the field of polymer materials technology, providing a PET elastomer, composite material, dynamic covalent network polymer, and its preparation method and application. The elastomer is prepared by in-situ self-assembly of crown ether-primary amide dual-functionalized PET through melt blending. Its molecular network integrates a quasi-rotaxane supramolecular crosslinking network. This structure is formed by the host-guest interaction between the crown ether and the primary amide, and can act as a sliding crosslinking point to dissipate energy through the sliding of cyclic components. This application employs a two-step end-capping-in-situ self-assembly process to overcome the technical obstacles of low PET chain-end activity and poor compatibility between polyrotaxane and PET, achieving molecular-level dispersion of quasi-rotaxane in the PET matrix. This fully utilizes the molecular pulley effect to achieve breakthrough toughening of the elastomer. Simultaneously, it combines rigid nanofillers modified with aminosilane coupling agents to form a soft-hard synergistic network, enabling the PET composite material to maintain high toughness while simultaneously improving strength, modulus, and thermal properties.

This invention discloses a silicon-based anode binder for lithium-ion batteries and its preparation method, relating to the field of silicon-based anode technology. The method includes first ring-opening sulfonation of polyetheramine with 1,3-propanesulfonyl lactone in an aqueous phase to obtain sulfonated polyetheramine; then, polyacrylic acid is activated by EDC·HCl and NHS and then amidated and grafted onto the sulfonated polyetheramine to obtain sulfonated polyetheramine-grafted polyacrylic acid; finally, the aqueous solution of this graft is in-situ coordinated with 2-methylimidazole and zinc nitrate to generate ZIF-8 nanoparticles, and then succinic acid and choline chloride are added for regulation to obtain the binder. This invention achieves dual modification through molecular grafting of flexible sulfonated polyether segments and in-situ construction of a three-dimensional ZIF-8 conductive network, utilizing succinic acid and choline chloride to eliminate competitive coordination of active groups, significantly improving ionic conductivity and stabilizing the electrode structure.

The application belongs to the technical field of biological medicine, and particularly relates to a biomimetic nano delivery system based on MRSA outer vesicle coating and application thereof. The application first couples chitosan oligosaccharide and monocarboxylated curcumin through an amide reaction to synthesize an amphiphilic polymer carrier, then loads vancomycin, daptomycin and other drugs through self-assembly to obtain a drug micelle, and finally coats the drug micelle with MRSA outer vesicle to successfully prepare a targeted biomimetic nano delivery system. The prepared biomimetic nano delivery system has excellent antibacterial effect, can realize targeted delivery and long-acting release of antibacterial drugs at an infection site, and is expected to overcome the bottleneck of drug resistance and insufficient drug penetration in traditional treatment, and provides a potential solution for the treatment of diseases such as periprosthetic infection.

This invention discloses an anaerobic biodegradable masterbatch for cast film of sanitary materials, characterized in that its main components, by mass percentage, include: 0.5-3% cypermethrin, 3-6% copper sulfate, 0.1-0.5% metal inorganic salt coating agent, 1-4% ammonium molybdate, 5-10% PLA, 5-10% nano starch, 1-5% carbamide, 7-12% fumed silica, and the balance being a biodegradable resin carrier. The preparation method includes dispersion treatment, centering treatment, structuring treatment, carrier implantation, and plasticizing granulation. The invention also discloses an anaerobic biodegradable cast film for sanitary materials, comprising the following components by mass percentage: 83.4%-97.13% PE-based cast film substrate for sanitary materials, 1-5% PE wax, 1-7.5% degradation masterbatch, 0.15-0.3% dispersant, 0.02-0.2% antioxidant, 0.2-0.6% white oil, 0.5-3% PE grafted maleic anhydride, and 0.2-2% stabilizer. The manufacturing method includes: material preparation, calcium carbonate pretreatment, melting, filtration, and casting. This invention achieves complete anaerobic biodegradation of PE cast leak-proof and breathable films, and also has antibacterial properties during normal use, making it suitable as a breathable film and base film for disposable sanitary materials.

This invention relates to a novel bio-based esteramide mixture and its use as a solvent, and more particularly as a polar aprotic solvent, for example, for dissolving agricultural surfactants in agricultural formulations.

The present invention belongs to the technical field of pesticides, and specifically relates to a pyridine amide compound and the use thereof. The compound is as represented by formula I, wherein W1 is O or S; R1 is hydrogen, alkyl, alkenyl, alkynyl, etc.; R3, R4 and R5 are each independently hydrogen, halogen, alkyl, etc.; and X1, X2, X3, X 4, X5, Y1, Y2, X3 and Y4 are each independently hydrogen, halogen, alkyl, etc. The compound has a good bactericidal effect.

This invention discloses a composition containing isoxaflutole and lambda-cyhalothrin, and its uses. The insecticide composition comprises isoxaflutole and lambda-cyhalothrin, with a mass fraction ratio of 1:1-50 between the two active components. Within a certain ratio range, the composition of this invention exhibits a significant synergistic effect against diamondback moth and flea beetles, which is beneficial for achieving reduced pesticide use and increased efficiency, meeting the requirements of the green and environmentally friendly trend in pesticides.

The invention belongs to the technical field of pesticides, and relates to 11 bactericide compositions for mainly preventing and treating crop diseases caused by pyricularia oryzae and colletotrichum gloeosporioides. The compound YJY-22 provided by the invention is novel in structure and unique in action mode, and has no cross resistance with isoprothiolane, fenoxanil, pyraclostrobin, tricyclazole, azoxystrobin, mancozeb, captan, difenoconazole, prochloraz, chlorothalonil and tebuconazole. As the action mechanism of the compound YJY-22 is different from that of the medicament, and the compound YJY-22 and the medicament have no cross resistance, the compound YJY-22 and the medicament are compounded, so that the sterilization range can be expanded, the sterilization effect can be enhanced, the drug resistance of phytopathogen can be delayed, the safety to crops is good, the prevention and control spectrum is expanded, and the requirements of pesticide reduction and synergism are met.

This invention discloses a composition of chlorpyrifos and a safener for controlling annual broadleaf weeds in soybean-corn strip intercropping fields, and its application. The composition of chlorpyrifos and a safener (pyrazosulfuron, bis(oxazolyl)sulfuron, and cyclopropanesulfonamide) in a specific ratio significantly alleviates phytotoxicity to corn in soybean-corn intercropping fields, while maintaining the control efficacy against annual broadleaf weeds (such as *Eclipta prostrata*, *Abutilon theophrasti*, and *Celosia argentea*). This invention solves a major problem in soybean-corn strip intercropping: limited use of herbicides, narrow weed control spectrum, and unsatisfactory weed control. It is beneficial for the promotion of soybean-corn strip intercropping technology. The composition of this invention is a feasible synergistic herbicide-safener combination for controlling annual broadleaf weeds in soybean-corn strip intercropping fields.

This invention provides a silicon-based anode slurry based on amide-bonded polyimide and its application. The silicon-based anode slurry includes an anode active material and a binder material. The anode active material includes a silicon-containing active material, and the binder material includes polyimide and / or its precursor, wherein the precursor is polyamic acid. The polyamic acid is obtained by polycondensation of a diamine monomer and a dianhydride monomer. The polyimide is obtained by imidization of the polyamic acid. The diamine monomer includes an amide-bonded diamine monomer, and the dianhydride monomer includes an aromatic tetracarboxylic acid dianhydride monomer. This invention introduces an amide-bonded structure into the polyimide backbone to construct a functionalized polyimide binder that combines multiple hydrogen bonding effects with moderate electrolyte compatibility, thereby enhancing the interfacial adhesion between the binder and the silicon active material and inhibiting its swelling in the electrolyte.

The application discloses a tri-substituted tetrahydroisoquinoline amide derivative with a novel structure or a pharmaceutically acceptable salt thereof, which is a compound shown in formula I. The compound has a strong inhibiting capacity on immune cell migration, the compound itself has high permeability and good water solubility, and can be used as an immune cell migration inhibitor and used for developing a medicine for treating ophthalmic diseases such as dry eye.

This invention discloses a polyolefin composite material, its preparation method, and its application. The polyolefin composite material comprises the following components by weight: 88-112 parts polyolefin resin; 0.5-4 parts organic pigment yellow; 0.1-1.5 parts phthalocyanine green; and 1-15 parts dispersing agent. The dispersing agent comprises polar-group grafted olefin polymers and / or aromatic cyclic olefin copolymers. The polar groups in the polar-group grafted olefin polymers include one or more of the following: phosphate ester groups, phosphate groups, sulfonic acid groups, sulfonate groups, carboxylic acid groups, carboxylate groups, amino groups, quaternary ammonium salt groups, amide groups, acrylic acid groups, or maleic anhydride groups. This invention, by adding specific dispersing agents to a high-chroma polyolefin system, obtains a polyolefin composite material with high chroma and good precipitation performance.