57 results about "Infertility" patented technology

The invention discloses a primer probe group and a kit for joint detection of mycoplasma genitalium, ureaplasma urealyticum and chlamydia trachomatis, and belongs to the technical field of molecular biological detection. The primer probe group comprises a primer probe group A for directly detecting a mycoplasma genitalium mgpB gene, a primer probe group B for directly detecting a ureaplasma urealyticum ureB gene and a primer probe group C for directly detecting a chlamydia trachomatis ompA gene; the kit comprises a PCR (Polymerase Chain Reaction) reaction solution and the primer probe group. Nucleic acid extraction is not needed, the detection cost is greatly reduced, the experiment time is shortened, meanwhile, the specificity and accuracy are still guaranteed, meanwhile, the sensitivity is improved, and the method has wide application prospects in the fields of non-gonococcal genital tract infection main pathogen detection, infertility and prenatal and postnatal care screening and the like. And the kit has important significance on clinical diagnosis, early treatment and prevention of diseases, prevalence and the like.

The systems and methods of the invention provide several improvements directed at fertility treatment. These improvements include an expert / AI system configured to guide a caregiver, e.g., a physician, through the process of providing fertility treatment. They also include a communication system between the caregiver and a patient, which is moderated by the expert / AI system.

LNPs can penetrate uterine mucosa to deliver therapeutic or prophylactic agents such as functional nucleic acids to the endometrium. Targeting of the LNPs using ligands expressed at particular times in an endometrial cycle ensures that the LNPs penetrate and release the mRNA primarily to the tissue associated with the peak time period for implantation, thereby providing a means to address infertility, as well as for treatment of other disorders such as cancer.

The present invention relates to a Lactobacillus salivarius strain deposited at the Spanish Type Culture Collection (CECT) under the accession number 5713, or a mutant thereof, for use in the treatment and / or prevention of infertility or recurrent miscarriage in a female subject. Furthermore, the present invention relates to an in vitro monitoring method for monitoring the therapeutic effect of the treatment of infertility or recurrent miscarriage in a female subject with a Lactobacillus salivarius strain deposited at the CECT under the accession number 5713, or a mutant thereof.

The invention discloses a formula and application of a compound infertility agent containing clarithromycin and quinestrol and based on CYP enzyme activity inhibition. The clarithromycin composition comprises clarithromycin, quinestrol and baits. The CYP enzyme inhibitor and the endocrine sterilant are combined for use, so that the synergist can effectively inhibit the activity of CYP enzyme in tissues such as livers of rats, the metabolic clearance rate of the sterilant is remarkably reduced, and the oral bioavailability and the system exposure level of the sterilant are improved. Therefore, when the same infertility effect is achieved, the use dosage of the infertility agent can be greatly reduced, so that the cost is saved, and the environmental load is reduced; or under the same dosage, a more thorough and more lasting population sterility effect can be obtained, and the practicability and competitiveness of a pest mouse sterility control technology are greatly improved.

The invention discloses a pharmaceutical composition for treating corpus luteum insufficiency type infertility as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The technical problem to be solved is to provide the pharmaceutical composition for treating the LPD type infertility, which is simpler in formula, lower in cost and better in treatment effect. According to the technical scheme, the pharmaceutical composition is prepared from the following raw materials: codonopsis pilosula, astragalus membranaceus, fried rhizoma atractylodis macrocephalae, angelica sinensis, semen cuscutae, fried eucommia ulmoides, fried teasel root, honey-fried licorice root, processed radix aconiti carmichaeli and cornu cervi degelatinatum. The pharmaceutical composition provided by the invention can improve ovarian injury, ferroptosis phenomenon, embryo implantation disorder, uterine artery blood perfusion and the like caused by LPD, and is helpful for various pathological problems related to LPD.

The invention relates to the technical field of probiotic application, in particular to application of lactobacillus crispatus HC1261 in preparation of a microbial agent for improving female reproductive health and a composition for improving vagina inflammation. The lactobacillus crispatus HC1261 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on May 16, 2023, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.27355; the microbial inoculum for improving female reproductive health can reduce the load of the ureaplasma urealyticum in the vagina. The lactobacillus crispatus HC1261 can be used for pertinently reducing the load of the ureaplasma urealyticum in the vagina, and can be used for reducing the related health risks of urethritis, cervicitis, pelvic inflammation, infertility and the like caused by the ureaplasma urealyticum.

Provided herein are methods and compositions comprising pulsatile follicle stimulating hormone (FSH). The pulsatile FSH may be used in methods of treating infertility, restoring normal hormonal levels, stimulating secretion of a sex steroid, treating or preventing fatty tissue accumulation, treating or preventing loss of bone density, preventing ovarian inflammation, and / or promoting metabolic health.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a sperm-nourishing seed jade decoction and application thereof to improvement of endometrial receptivity, the sperm-nourishing seed jade decoction is composed of 30 g of radix rehmanniae preparata, 15 g of cornus officinalis, 15 g of radix paeoniae alba and 15 g of angelica sinensis, by inhibiting the epithelial-mesenchymal transition (EMT) process, the expression of E-cadherin and beta-catenin is up-regulated, the expression of Vimentin is down-regulated, and the endometrial receptivity is improved. Therefore, the stability and integrity of endometrial epithelium are maintained, intimal thickening, gland hyperplasia and angiogenesis are promoted, and an effective treatment strategy can be provided for infertility caused by thin endometrium.

An object of a system according to an embodiment is to provide accurate advice and continuous support to a user who receives infertility treatment.SOLUTION: A system includes a collection unit, an analysis unit, a proposal unit, and a support unit. The collection unit collects health data of a user. The analysis unit analyzes the data collected by the collection unit. The proposal unit proposes a pregnancy timing and a lifestyle on the basis of an analysis result obtained by the analysis unit. The support unit provides support based on the individual treatment plan on the basis of the content proposed by the proposal unit.SELECTED DRAWING: Figure 1

The invention discloses a traditional Chinese medicine composition for treating infertility. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: red ginseng, pseudo-ginseng, fructus corni, fructus lycii, angelica sinensis, Chinese yam, poria cocos, dragon's blood, ligusticum wallichii, carthamus tinctorius, teasel root, fructus alpiniae oxyphyllae, radix cyathulae, pawpaw, cynomorium songaricum, fleece-flower root, wild gastrodia elata, combined spicebush root, hippocampus, cinnamon, semen cuscutae, eucommia ulmoides, glossy privet fruit, fenugreek, tribulus terrestris, lycium ruthenicum and native copper. , fructus rosae laevigatae and magnetite. Compared with similar medicines in the market, the traditional Chinese medicine composition can effectively improve related indexes of reproduction of patients, increase the thickness of endometrium, promote follicular development, adjust the menstrual cycle and improve the semen quality, so that the pregnancy condition is improved.

Methods for producing an artificial follicle are disclosed. Also disclosed are artificial follicles produced by such methods, in vitro methods of rejuvenating an oocyte, and methods of treating infertility or improving fertility.

The application belongs to the technical field of biotechnology and medicine, and specifically discloses a single-domain antibody-exosome compound (Nb-EMX2-Exos) targeting EMX2 as well as a preparation method and application thereof. The compound is prepared by covalently coupling a single-domain antibody (Nb-EMX2) specifically binding to EMX2 protein to the surface of endometrial stem cell-derived exosomes (ESC-Exos). In-vitro experiments show that the compound can specifically recognize and efficiently internalize into damaged endometrial stromal cells with high expression of EMX2, and significantly promote the migration and proliferation of the cells. In-vivo experiments further prove that the compound can precisely target and enrich in damaged endometrial tissue, effectively promote the structural repair (thicken the endometrium and reduce fibrosis) of the endometrium, and completely restore the fertility function. The application provides a novel targeted treatment preparation for solving the problems of poor targeting of natural exosomes and limited treatment effect, and has important application value in the treatment of endometrial injury repair and related infertility.

The invention relates to substantially complete vaginal microbiota preparations for treating infertility and therapeutic methods to do so.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

The invention discloses a novel application of a compound beta-alanine (beta-alanine) in preparation of a medicine for improving oocyte quality and treating ovarian endometriosis (OEM) related infertility, and belongs to the technical field of biological medicines. An OEM animal model proves that beta-alanine can remarkably improve reproductive function disorder of model animals, specifically, follicular dysplasia caused by endometriosis is effectively relieved, the fertility is improved, and the litter size is increased; in the aspect of oocyte quality, the compound can promote normal discharge of a first polar body in an oocyte in-vitro maturation process, reduce cytoplasm fragmentation, recover spindle body form and microtubule arrangement, enhance mitochondrial membrane potential stability and maintain the integrity of an ultrastructure. The results show that beta-alanine can reverse oocyte quality reduction caused by ovarian endometriosis in multiple dimensions, has a definite treatment potential, and provides an important candidate molecule for developing a novel assisted reproduction intervention strategy for targeting oocyte health.

The invention belongs to the technical field of PCOS infertility intervention, and particularly discloses angle-adjustable PCOS endocrine regulation glasses and method based on an AI algorithm, the glasses comprise a glasses frame and a glasses bracket, an adjustable light plate is hinged to the glasses frame, an intervention light source is integrated on the inner side of the adjustable light plate, and the irradiation angle of the light source is adjusted through rotation of the adjustable light plate; a pupil distance sensor is arranged on the inner side of the adjustable light plate, a control module is arranged in the lens frame, an AI algorithm is arranged in the control module, target light intensity parameters are calculated through a preset mathematical model, a light source is finely adjusted, and therefore it is ensured that the light intensity accurately acts on a retina target area, and hypothalamic repair hormone secretion is induced. The AI algorithm is linked with the angle of the adjustable light plate and the pupil distance to correct the light intensity in real time, it is ensured that the retina is accurately illuminated, and hypothalamus is effectively induced to repair hormone secretion so as to intervene in PCOS infertility.

1. The name of the design product: intelligent light regulation glasses (adjustable angle). 2. The use of the design product: for treating polycystic ovary infertility by using AI algorithm. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The present invention relates to pharmaceutical, dietary and / or food compositions exerting the ability to activate the endogenous production of hydrogen sulfide (H2S) so to feed the redox buffer capacity and to boost the natural ability to compensate both oxidative and reductive stress.The invention further relates to the use of the aforementioned compositions to correct signs of metabolic derangements such as: oxy-redox imbalances including reductive stress, mitochondrial dysfunction and bioenergetics, insulin resistance, endothelial dysfunction and hyperhomocysteinemia. Accordingly, the composition of the present invention can be used as a medicament for the treatment of hypertension, atherosclerosis and cardiovascular disease, erectile dysfunction, viral infections and inflammatory lung injuries, diabetes and PCOS, autoimmune diseases, neurodegeneration, repeated implantation failure and repeated miscarriage and infertility in both men and women.

The invention relates to a traditional Chinese medicine composition and a preparation method and application thereof, and belongs to the technical field of biological medicine. The traditional Chinese medicine composition is prepared from thirty traditional Chinese medicine raw materials such as bull penis, cortex cinnamomi and alfalfa seeds and refined honey. The traditional Chinese medicine raw materials are crushed and mixed and then are prepared into honeyed boluses with the refined honey to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition disclosed by the invention has the effects of warming and nourishing brain and kidney, and benefiting heart and replenishing essence, and can be used for effectively treating impotence, depression, spermatorrhea, premature ejaculation, body deficiency, emaciation, neurasthenia, premature ovarian insufficiency, ovarian reserve hypofunction, climacteric syndrome, infertility and / or infertility. The dracocephalum moldavica, the anchusa, the chicory and the hawthorn are further added, so that the efficacy of treating the impotence can be improved, and the effect of treating the hyperlipidemia is achieved.

This invention belongs to the field of biomedical technology and provides an application of linear diarylheptane compounds in reproductive-related diseases, including infertility, hyperandrogenemia, menstrual cycle disorders, ovulation disorders, and other reproductive disorders. These compounds can promote and restore ovulation, reduce hyperandrogenemia, and improve menstrual cycles, with good safety and no obvious toxic side effects. They can be used to prepare drugs for the prevention and treatment of reproductive disorders and for ovulation induction.

This invention provides a method and system for integrated data correlation analysis based on clinical features and molecular indicators, belonging to the field of medical data processing and intelligent prediction technology. The method includes: preprocessing collected clinical feature data and molecular indicator data to obtain a standardized structured dataset; extracting key clinical feature subsets and key molecular indicator subsets from the standardized structured dataset, and fusing them to generate a unified multidimensional fusion feature vector; dynamically calibrating at least three clinical phenotypic benchmarks in the unified multidimensional fusion feature vector using a clinical feature data spectrum, whereby the clinical phenotypic benchmarks are defined based on age feature spectrum nodes, infertility course trajectory critical scaling, and endometrial thickness quantification cutoff values. This invention can effectively complete the integrated correlation analysis of clinical features and molecular indicators and predict pregnancy outcomes, meeting the needs of precision clinical diagnosis and treatment.

The invention relates to the technical field of traditional Chinese medicine, in particular to an external traditional Chinese medicine composition for conditioning dysmenorrhea and infertility caused by cold in uterus, which is prepared from the following raw materials in parts by weight: 20g of radix clematidis, 5g of white pepper grains, 35g of fresh ginger, 30g of wheat, 15g of single garlic and 0.5 g of carbonized hair. The components are synergistic, acupoint stimulation and warm sweating are combined, cold in uterus is conditioned in a targeted manner, the traditional Chinese medicine composition has a remarkable auxiliary improvement effect on dysmenorrhea, infertility and other symptoms caused by cold in uterus, the preparation process is simple, complex equipment is not needed, patients can operate by themselves under guidance of professionals when the traditional Chinese medicine composition is used, convenience is high, special recipes and short-term indications are matched, and the traditional Chinese medicine composition is worthy of popularization and application. The conditioning effect is further consolidated, and the relapse possibility is reduced.

The invention discloses an application of 24-Epi brassinolide in promoting the development of female germline stem cells. Belongs to the technical field of reproductive biology. Female germline stem cells (FGSCs) are important cell models for studying the development of germ cells, however, the regulation and control mechanism of natural products on the development of the FGSCs still needs to be deeply explored. The invention aims at disclosing the regulation and control effect of 24-Epi brassinolide (24-Epibrassinolide, EBR) on FGSCs development and a molecular mechanism of the 24-Epi brassinolide on the FGSCs development by utilizing an FGSCs in-vitro development system and combining LongRNA-seq and RIC-seq technologies, and a new strategy is provided for treatment of infertility and optimization of a clinical treatment scheme.

The application discloses a preparation of a biological memristor and application of the biological memristor in sperm DNA breakage detection, and takes supernatant of a sample to be detected, and drops the supernatant on the surface of the memristor; after the memristor is connected with a detection platform, different voltage corresponding electrical signals are outputted, and the normal sperm and the sperm with DNA breakage are distinguished. The application has the characteristics of simple detection process, low cost, high sensitivity and fast response, and can quickly distinguish whether sperm DNA sequence breakage exists in sperm cells of a male patient with infertility.

The invention relates to a traditional Chinese medicine composition for treating polycystic ovarian syndrome infertility and application thereof, the traditional Chinese medicine composition can be used for treating polycystic ovarian syndrome infertility, has the effects of warming kidney and regulating thoroughfare, raising yang and discharging turbid, smoothing veins, harmonizing yin and yang, combining essence and blood and knotting embryos to promote follicular development when being applied to a patient with polycystic ovarian syndrome infertility, and has the effects of promoting follicular growth and promoting blood circulation. The ovum quality is improved, the abortion rate is reduced, and the pregnancy outcome is improved.

This invention provides the application of lecithin in the preparation of drugs for the prevention and / or treatment of infertility, belonging to the field of biomedical preparation technology. Specifically, it relates to the application of lecithin in the preparation of drugs for the prevention and / or treatment of infertility, recurrent miscarriage, and / or uterine decidualization disorders. The lecithin can effectively reduce TNF-α levels in early pregnancy, improve uterine decidualization disorders, and increase endometrial receptivity, thereby increasing pregnancy rates and providing a new approach for the treatment of infertility and recurrent miscarriage.

The invention relates to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating ovarian EMS infertility with kidney deficiency, qi depression, phlegm dampness and blood stasis constitution. Comprising the following components in parts by weight: 6-15 parts of cassia twig, 10-20 parts of moutan bark, 15-35 parts of salvia miltiorrhiza, 5-10 parts of peach kernel, 6-10 parts of safflower, 12-30 parts of red paeony root, 5-25 parts of angelica sinensis, 10-15 parts of rhizoma sparganii, 10-15 parts of curcuma zedoary, 1-3 parts of leech, 3-6 parts of scorpion, 10-15 parts of herba epimedii, 9-30 parts of gordon euryale seed, 15-30 parts of coix seed and 6 parts of liquorice. The prescription can effectively improve the size of ectopic cyst, further improves the overall curative effect on the whole, and is worthy of further clinical popularization.

The invention belongs to the field of biological medicines, and discloses application of glyceryl triacetate in preparation of a medicine for preventing or treating infertility. According to the application, ACLY defects are bypassed by supplementing acetyl donor substances, the histone acetylation level is recovered, then the deciduation function is improved, the application can be effectively applied to prevention and treatment of recurrent abortion (RSA) and repeated embryo planting failure, and the new application of GTA in the field of medicine is expanded.

The present application provides a method for preparing human ovarian somatic cell-like cells. The present application establishes a method for preparing human ovarian somatic cell-like cells in vitro, which comprises stage-based culture based on human stem cells (including human pluripotent stem cells and human totipotent stem cells). The method of the present application can efficiently obtain functional human ovarian somatic cell-like cells, promote the differentiation ability of female germ stem cells (FGSC) cultured in vitro, and provide a new approach for assisted reproduction and treatment of infertility.