105 results about "Infertility" patented technology

Disclosed are methods of treating infertility or increasing fertility of a female subject by administering a therapeutic MSC secretome product made by a method comprising culturing bone marrow-derived MSCs under conditions that include oxygen tension below 5% and a culture media with a pH below 7.

The invention discloses a primer probe group and a kit for joint detection of mycoplasma genitalium, ureaplasma urealyticum and chlamydia trachomatis, and belongs to the technical field of molecular biological detection. The primer probe group comprises a primer probe group A for directly detecting a mycoplasma genitalium mgpB gene, a primer probe group B for directly detecting a ureaplasma urealyticum ureB gene and a primer probe group C for directly detecting a chlamydia trachomatis ompA gene; the kit comprises a PCR (Polymerase Chain Reaction) reaction solution and the primer probe group. Nucleic acid extraction is not needed, the detection cost is greatly reduced, the experiment time is shortened, meanwhile, the specificity and accuracy are still guaranteed, meanwhile, the sensitivity is improved, and the method has wide application prospects in the fields of non-gonococcal genital tract infection main pathogen detection, infertility and prenatal and postnatal care screening and the like. And the kit has important significance on clinical diagnosis, early treatment and prevention of diseases, prevalence and the like.

The systems and methods of the invention provide several improvements directed at fertility treatment. These improvements include an expert / AI system configured to guide a caregiver, e.g., a physician, through the process of providing fertility treatment. They also include a communication system between the caregiver and a patient, which is moderated by the expert / AI system.

The invention discloses a moxa stick containing traditional Chinese medicine components for treating infertility and a preparation method of the moxa stick, relates to the technical field of traditional Chinese medicine instruments, and mainly solves the technical problem of low skin permeation efficiency of the medicine components in the moxibustion process. According to the technical scheme, the preparation method comprises the following steps: preparing traditional Chinese medicine powder consisting of angelica sinensis, prepared rehmannia root, semen cuscutae, fructus lycii, ligusticum wallichii, rhizoma cyperi, salvia miltiorrhiza and borneol according to specific parts by mass, and controlling the average particle size to be 10-50 microns; the moxa and the traditional Chinese medicine powder are mixed according to the mass ratio of (3-5): 1 to form a medicine core layer; the periphery of the medicine core layer is wrapped with a pure moxa heat conduction layer with the thickness of 2-4 mm; and finally, wrapping the periphery of the heat conduction layer with a mulberry paper barrier layer with the thickness of 0.1-0.3 mm. Through the combined action of the three-layer structure, the medicine release and heat conduction path is optimized, the medicine transdermal efficiency is remarkably improved, and the high-efficiency traditional Chinese medicine moxa stick for treating infertility is prepared.

Nutraceutical food supplement for treatment of young women in post-puberty age suffering from polycystic ovary syndrome with symptoms like irregular menstruation cycles, insulin resistant diabetes, infertility, hair loss, acne and weight gain is provided. Formulations having myo-inositol and its D-chiro isomer along with plant proteins, a carbohydrate (inulin) and other plant fibres; along with well-defined proportions of vitamins (A, B1 to 6; B12 and C); several minerals like Ca, Cr, Fe, K, Mg, Mn, Na and Zn and essential amino acids like L-Glutamine, L-Lysine, and L-Taurine are provided.

This invention discloses a porous carbon-based dual-drug-loaded nanomaterial for sustained release. The material uses a thermosensitive polymer as a matrix and cellulose nanocrystals modified with cationic surfactants as a reinforcing phase, loading both hydrophilic and hydrophobic drugs. This material can be used to prepare therapeutic drugs for gynecological diseases and infertility, as well as drug delivery devices. Furthermore, this invention provides a uterine scaffold prepared using this material, which can be fabricated using 3D printing technology. Utilizing the PNIPAm hydrogel network and its temperature-responsive properties, hydrophilic drugs can be loaded at low temperatures. The high mechanical strength of CNC machining allows for the loading of hydrophobic drugs while improving the mechanical properties of the hydrogel matrix, thus solving the problems of easy detachment and bleeding in existing technologies.

LNPs can penetrate uterine mucosa to deliver therapeutic or prophylactic agents such as functional nucleic acids to the endometrium. Targeting of the LNPs using ligands expressed at particular times in an endometrial cycle ensures that the LNPs penetrate and release the mRNA primarily to the tissue associated with the peak time period for implantation, thereby providing a means to address infertility, as well as for treatment of other disorders such as cancer.

The present invention relates to a Lactobacillus salivarius strain deposited at the Spanish Type Culture Collection (CECT) under the accession number 5713, or a mutant thereof, for use in the treatment and / or prevention of infertility or recurrent miscarriage in a female subject. Furthermore, the present invention relates to an in vitro monitoring method for monitoring the therapeutic effect of the treatment of infertility or recurrent miscarriage in a female subject with a Lactobacillus salivarius strain deposited at the CECT under the accession number 5713, or a mutant thereof.

The invention discloses a formula and application of a compound infertility agent containing clarithromycin and quinestrol and based on CYP enzyme activity inhibition. The clarithromycin composition comprises clarithromycin, quinestrol and baits. The CYP enzyme inhibitor and the endocrine sterilant are combined for use, so that the synergist can effectively inhibit the activity of CYP enzyme in tissues such as livers of rats, the metabolic clearance rate of the sterilant is remarkably reduced, and the oral bioavailability and the system exposure level of the sterilant are improved. Therefore, when the same infertility effect is achieved, the use dosage of the infertility agent can be greatly reduced, so that the cost is saved, and the environmental load is reduced; or under the same dosage, a more thorough and more lasting population sterility effect can be obtained, and the practicability and competitiveness of a pest mouse sterility control technology are greatly improved.

The invention discloses a pharmaceutical composition for treating corpus luteum insufficiency type infertility as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The technical problem to be solved is to provide the pharmaceutical composition for treating the LPD type infertility, which is simpler in formula, lower in cost and better in treatment effect. According to the technical scheme, the pharmaceutical composition is prepared from the following raw materials: codonopsis pilosula, astragalus membranaceus, fried rhizoma atractylodis macrocephalae, angelica sinensis, semen cuscutae, fried eucommia ulmoides, fried teasel root, honey-fried licorice root, processed radix aconiti carmichaeli and cornu cervi degelatinatum. The pharmaceutical composition provided by the invention can improve ovarian injury, ferroptosis phenomenon, embryo implantation disorder, uterine artery blood perfusion and the like caused by LPD, and is helpful for various pathological problems related to LPD.

The present inventive concept is related to a modified follicle-stimulating hormone (FSH), in particular, a hypo-glycosylated form of FSH, as well as compositions and formulations including, nucleic acids encoding, cell lines expressing, and methods of using the hypo-glycosylated FSH as disclosed herein. These methods of use include methods of treating infertility, methods of inducing follicle growth and / or maturation, methods of inducing oocyte / egg growth and / or maturation, methods of stimulating sex steroid secretion, methods of treating or preventing bone density loss, and methods of treating or preventing fatty tissue accumulation.

The invention relates to the technical field of probiotic application, in particular to application of lactobacillus crispatus HC1261 in preparation of a microbial agent for improving female reproductive health and a composition for improving vagina inflammation. The lactobacillus crispatus HC1261 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on May 16, 2023, the preservation address is No.3, No.1 yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number is CGMCC No.27355; the microbial inoculum for improving female reproductive health can reduce the load of the ureaplasma urealyticum in the vagina. The lactobacillus crispatus HC1261 can be used for pertinently reducing the load of the ureaplasma urealyticum in the vagina, and can be used for reducing the related health risks of urethritis, cervicitis, pelvic inflammation, infertility and the like caused by the ureaplasma urealyticum.

Provided herein are methods and compositions comprising pulsatile follicle stimulating hormone (FSH). The pulsatile FSH may be used in methods of treating infertility, restoring normal hormonal levels, stimulating secretion of a sex steroid, treating or preventing fatty tissue accumulation, treating or preventing loss of bone density, preventing ovarian inflammation, and / or promoting metabolic health.

Materials and methods of treating a patient with type 2 diabetes mellitus, metabolic syndrome, obesity, infertility, high blood pressure, hyperthyroidism, and hypothyroidism, hyperlipidaemia, osteoporosis, osteoarthritis, hypoadrenalism, polycystic ovary syndrome, or Parkinson's disease comprising administering a therapeutically effective amount of ex vivo cultured activated peripheral blood mononuclear cells (PBMCs) to the patient. The ex vivo cultured activated cells are activated and cultured in a presence of a cytokine and may be autologous or allogeneic relative to the patient.

Tracking ovulatory hormone levels is key to detecting fertility windows and providing actionable information for facilitating or preventing conception, as well as assessing and managing infertility and other conditions associated with hormone imbalances. Conventional fertility methods suffer drawbacks associated with invasive sampling, inadequate prediction accuracies, or repetitive user intervention. To overcome these and other limitations, the present Applicants developed a wearable device for contemporaneous monitoring of estradiol, progesterone, and luteinizing hormone and physiological biomarkers (temperature, pH). Flexible field-effect transistors functionalized with biomarker-specific aptamers enabled sensitive and selective determination of the three principal ovulatory hormones across physiological ranges in artificial human sweat. By including an on-demand iontophoretic sweat sampling feature, the present Applicants established an integrated wearable platform for high-accuracy, minimally invasive, rapid, and personalized ovulatory status monitoring.

The invention relates to the technical field of biological medicine, and particularly discloses a recombinant bovine interferon coated sustained release microsphere and a preparation method and application thereof, an ultrasonic re-emulsification method is used for replacing bare-handed re-emulsification, 2.5% of trehalose is added into an internal water phase W1, and the protein concentration of the internal water phase W1 is reduced by 30 mg / ml to 25 mg / ml. According to the method provided by the invention, the encapsulation efficiency reaches 90% or above, the recovery rate reaches 95%, the drug loading rate is close to 5%, the balling rate exceeds 90%, and the in-vitro effective slow release time reaches about 10 days; through clinical supplement of the coated slow-release rbIFNT, the pregnancy rate of the receptor cattle in the initial test and the re-test is obviously improved by about 10%, and the pregnancy rate of the repeat breeding infertility young cattle in the initial test is obviously improved by about 15%.

Methods using and compositions including FSH for use in the treatment of infertility are described, wherein the dose is selected based on the patient's age to optimise cumulative efficiency and / or reduce OHSS risk.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a sperm-nourishing seed jade decoction and application thereof to improvement of endometrial receptivity, the sperm-nourishing seed jade decoction is composed of 30 g of radix rehmanniae preparata, 15 g of cornus officinalis, 15 g of radix paeoniae alba and 15 g of angelica sinensis, by inhibiting the epithelial-mesenchymal transition (EMT) process, the expression of E-cadherin and beta-catenin is up-regulated, the expression of Vimentin is down-regulated, and the endometrial receptivity is improved. Therefore, the stability and integrity of endometrial epithelium are maintained, intimal thickening, gland hyperplasia and angiogenesis are promoted, and an effective treatment strategy can be provided for infertility caused by thin endometrium.

The invention provides an infertility patient pregnancy prediction method based on active learning and an integrated model, and the method comprises the following steps: carrying out the preprocessing of collected data, including classification variable coding, standardization processing and multi-dimensional abnormal value detection; generating a few categories of synthetic samples through an SMOTE technology, and optimizing data distribution in combination with a Tomek Links method; training a pregnancy prediction model based on machine learning models such as a random forest and XGBoost; the prediction results of the multiple basic models are fused through the Blending technology; based on an uncertainty sampling strategy, selecting samples for labeling and carrying out mixed training; and the pregnancy success prediction probability and credibility are output by inputting patient data. According to the method, the prediction accuracy and stability of the model can be improved, the robustness of the model to noise data and boundary samples is improved, the generalization ability of the model on new data is improved to a certain extent, doctors and patients can obtain more accurate treatment decision support, and the success rate and efficiency of IVF-ET treatment are improved.

A device, system, and method for closing and reopening a sphincter in a body, such as for closing and opening an internal urinary sphincter of a bladder, thereby blocking retrograde ejaculation, by employing controllable electromagnets. Using the present device, system, and method, the patients can selectively close their bladder's sphincter as desired, for example, to selectively block retrograde ejaculation, preventing semen from entering the bladder of the patient and thereby preventing infertility of the patient. The solution helps regain the elasticity function of the sphincter to allow it to close as per normal to prevent retrograde ejaculation. A series of magnetizable metal objects are positioned in or surrounding the bladder wall at the junction with the urethra, with each of the magnetizable metal objects being electromagnetically controlled to have a controllable closing / reopening of the bladder's sphincter, thereby preventing retrograde ejaculation while also allowing the passage of urine as per normal.

An object of a system according to an embodiment is to provide accurate advice and continuous support to a user who receives infertility treatment.SOLUTION: A system includes a collection unit, an analysis unit, a proposal unit, and a support unit. The collection unit collects health data of a user. The analysis unit analyzes the data collected by the collection unit. The proposal unit proposes a pregnancy timing and a lifestyle on the basis of an analysis result obtained by the analysis unit. The support unit provides support based on the individual treatment plan on the basis of the content proposed by the proposal unit.SELECTED DRAWING: Figure 1

The invention discloses a traditional Chinese medicine composition for treating infertility. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: red ginseng, pseudo-ginseng, fructus corni, fructus lycii, angelica sinensis, Chinese yam, poria cocos, dragon's blood, ligusticum wallichii, carthamus tinctorius, teasel root, fructus alpiniae oxyphyllae, radix cyathulae, pawpaw, cynomorium songaricum, fleece-flower root, wild gastrodia elata, combined spicebush root, hippocampus, cinnamon, semen cuscutae, eucommia ulmoides, glossy privet fruit, fenugreek, tribulus terrestris, lycium ruthenicum and native copper. , fructus rosae laevigatae and magnetite. Compared with similar medicines in the market, the traditional Chinese medicine composition can effectively improve related indexes of reproduction of patients, increase the thickness of endometrium, promote follicular development, adjust the menstrual cycle and improve the semen quality, so that the pregnancy condition is improved.

Methods for producing an artificial follicle are disclosed. Also disclosed are artificial follicles produced by such methods, in vitro methods of rejuvenating an oocyte, and methods of treating infertility or improving fertility.

The application belongs to the technical field of biotechnology and medicine, and specifically discloses a single-domain antibody-exosome compound (Nb-EMX2-Exos) targeting EMX2 as well as a preparation method and application thereof. The compound is prepared by covalently coupling a single-domain antibody (Nb-EMX2) specifically binding to EMX2 protein to the surface of endometrial stem cell-derived exosomes (ESC-Exos). In-vitro experiments show that the compound can specifically recognize and efficiently internalize into damaged endometrial stromal cells with high expression of EMX2, and significantly promote the migration and proliferation of the cells. In-vivo experiments further prove that the compound can precisely target and enrich in damaged endometrial tissue, effectively promote the structural repair (thicken the endometrium and reduce fibrosis) of the endometrium, and completely restore the fertility function. The application provides a novel targeted treatment preparation for solving the problems of poor targeting of natural exosomes and limited treatment effect, and has important application value in the treatment of endometrial injury repair and related infertility.

The invention relates to substantially complete vaginal microbiota preparations for treating infertility and therapeutic methods to do so.

In an illustrative embodiment, methods and systems for treating fertility conditions in women diagnosed with polycystic ovary syndrome (PCOS), endometriosis, and / or adenomyosis using electrical neurostimulation include delivering neurostimulation therapy via electrical or mechanical stimulation elements, the neurostimulation therapy including applying first neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more first regions of skin of the subject to directly and / or indirectly activate a nucleus tractus solitary (NTS) and / or a trigeminal cervical complex (TCC) to activate anti-inflammatory pathways, and applying second neurostimulation pulses using electrical neurostimulation or mechanical neurostimulation at one or more second regions of skin of the subject to directly and / or indirectly activate vagal neural fibers and / or trigeminal neural fibers, wherein the neurostimulation pulses are configured to increase a parasympathetic / sympathetic (P / S) ratio.

The invention discloses a novel application of a compound beta-alanine (beta-alanine) in preparation of a medicine for improving oocyte quality and treating ovarian endometriosis (OEM) related infertility, and belongs to the technical field of biological medicines. An OEM animal model proves that beta-alanine can remarkably improve reproductive function disorder of model animals, specifically, follicular dysplasia caused by endometriosis is effectively relieved, the fertility is improved, and the litter size is increased; in the aspect of oocyte quality, the compound can promote normal discharge of a first polar body in an oocyte in-vitro maturation process, reduce cytoplasm fragmentation, recover spindle body form and microtubule arrangement, enhance mitochondrial membrane potential stability and maintain the integrity of an ultrastructure. The results show that beta-alanine can reverse oocyte quality reduction caused by ovarian endometriosis in multiple dimensions, has a definite treatment potential, and provides an important candidate molecule for developing a novel assisted reproduction intervention strategy for targeting oocyte health.

The present invention discloses a Chinese medicine composition for preventing and treating premature ovarian failure and its application. It belongs to the technical field of traditional Chinese medicine. The Chinese medicine composition of the present invention comprises Euryale ferox, Aquilaria sinensis, Santalum album, processed Pinellia ternata, Rhubarb, White cardamom, Alpinia officinalis, processed Arisaema consanguineum, processed Chuanwu, Asarum sieboldii, Citrus aurantium and Piper longum. The prescription of the present invention follows the principle of "monarch, minister, assistant and envoy" compatibility in traditional Chinese medicine and belongs to a compound Chinese medicine preparation, which needs to regulate reproductive endocrine function through the synergistic effect of multiple medicinal materials. It focuses on infertility and premature ovarian failure caused by phlegm-dampness and blood stasis combined with kidney yang deficiency. The existing technology mostly focuses on simple kidney tonification (such as Rehmannia glutinosa and Cornus officinalis) or blood circulation (such as peach kernel and safflower), while the prescription of the present invention integrates multiple functions such as removing dampness, warming and promoting circulation, purging blood stasis and promoting qi, and is more targeted.

The invention belongs to the technical field of PCOS infertility intervention, and particularly discloses angle-adjustable PCOS endocrine regulation glasses and method based on an AI algorithm, the glasses comprise a glasses frame and a glasses bracket, an adjustable light plate is hinged to the glasses frame, an intervention light source is integrated on the inner side of the adjustable light plate, and the irradiation angle of the light source is adjusted through rotation of the adjustable light plate; a pupil distance sensor is arranged on the inner side of the adjustable light plate, a control module is arranged in the lens frame, an AI algorithm is arranged in the control module, target light intensity parameters are calculated through a preset mathematical model, a light source is finely adjusted, and therefore it is ensured that the light intensity accurately acts on a retina target area, and hypothalamic repair hormone secretion is induced. The AI algorithm is linked with the angle of the adjustable light plate and the pupil distance to correct the light intensity in real time, it is ensured that the retina is accurately illuminated, and hypothalamus is effectively induced to repair hormone secretion so as to intervene in PCOS infertility.

Disclosed are methods of treating infertility or increasing fertility of a female subject by administering a therapeutic MSC secretome product made by a method comprising culturing bone marrow-derived MSCs under conditions that include oxygen tension below 5% and a culture media with a pH below 7.