10 results about "Endometrium" patented technology

The application discloses a traditional Chinese medicine composition for treating pregnancy embryo residue, a preparation method and application thereof and a pharmaceutical preparation, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following components: Astragalus membranaceus, Angelica sinensis, Ligusticum chuanxiong, Sparganium stoloniferum, Curcuma zedoaria, Semen Persicae, Herba impatiens, Radix Trichosanthis, Solpugid and Motherwort. Clinical efficacy observation shows that the traditional Chinese medicine composition can effectively promote the discharge of residual tissue, avoid the operation of a palace cleaning operation, shorten the time of vaginal bleeding, promote the repair of endometrium, and has good patient compliance and good tolerance, and no serious adverse reactions are found, and the effective rate is more than 90%. The traditional Chinese medicine composition is based on the theory of monarch, minister and assistant in traditional Chinese medicine, and the components are matched with each other, so that an excellent use effect is achieved.

The application provides a method for constructing an endometrial carcinoma CT image segmentation model and application thereof, including the following steps: acquiring multiple endometrial CT images labeled with cancerous regions as a training data set; constructing an endometrial carcinoma CT image segmentation architecture, wherein the endometrial carcinoma CT image segmentation architecture is a U-Net structure including an encoding unit, a bottleneck layer and a decoding unit; and training the endometrial carcinoma CT image segmentation architecture with the training data set to obtain an endometrial carcinoma CT image segmentation model. The scheme explicitly captures multi-scale structural change information by constructing a multi-directional coding structure response operator and generating a coding structure gradient field, thereby strengthening the representation of thin and weak boundaries and small lesions to improve the segmentation accuracy of the model.

The application discloses a three-layer time sequence regulation type inflammation targeting composite repair system for repairing endometrial injury and a preparation method and application thereof. The system is a three-layer composite structure, which comprises, from outside to inside, (1) an outer ROS response hydrogel layer loaded with anti-inflammatory drugs, which can respond to early high expression of active oxygen to rapidly degrade the drugs, so that acute inflammation is inhibited; (2) a middle layer of targeted delivery and metabolic repair, which is a M1 macrophage membrane pseudo-loaded drug liposome (NMN@M-Lipo), which is exposed after the degradation of the outer hydrogel, actively targets the inflammation lesion through the M1 membrane, and slowly releases nicotinamide mononucleotide (NMN) to restore cell energy metabolism; and (3) an inner layer of cell recruitment and regeneration, which is a decellularized matrix scaffold loaded with SDF-1 alpha, which continuously releases SDF-1 alpha to recruit endogenous stem cells in the later repair stage, and promotes functional regeneration of the endometrium. The application utilizes the time sequence microenvironment changes of endometrial repair, and realizes the cascade regulation of 'anti-inflammation first, metabolic repair second, and regeneration promotion third'. Animal experiments show that the system can significantly restore the reproductive function of the injured endometrium and improve the number of offspring.

The utility model discloses a female reproductive examination expansion device, specifically relates to medical equipment technical field, including annular block, the left and right part middle part of annular block outer surface is connected with the lower expansion block who rotates jointly, the left and right part middle part of annular block outer surface is connected with the upper expansion block who rotates jointly, the upper expansion block is located the upper expansion block right above, the lower part fixedly connected with handle of annular block outer surface, the inside surface of annular block is provided with adjusting assembly. The female reproductive examination expansion device of the utility model, through setting adjusting assembly and telescopic component, make the upper expansion block and the lower expansion block can be expanded gradually slowly through adjusting assembly after entering female vagina, make female patient have the process of gradually adapting, thereby avoid producing damage to the endometrium, avoid producing the pain feeling, can check the different female vagina length simultaneously, need not change again, be convenient for medical staff to use.

The application discloses a method for culturing human periodontal ligament stem cells by using self-assembled mussel myoglobin. The method comprises the following steps: dissolving the self-assembled mussel myoglobin in PBS to adjust the pH to 7.0-8.0, and filtering and sterilizing; adding the self-assembled mussel myoglobin into a cell culture medium to prepare a working culture medium with a final concentration of 10-100 mu g / mL; resuspending the cells after digesting hPDLSCs, and adjusting the density to 3.0*10<5>-3.5*10<5> per mL; using the hanging drop culture method, 20-30 mu L of each drop is inoculated in the inner side of a culture dish cover, and human periodontal ligament stem cells are obtained after 2-5 days of culture. The wet adhesion characteristics of the self-assembled mussel myoglobin are used to significantly improve the structural stability of stem cell spheres and the internal cell survival rate, and to enhance the stemness maintenance, paracrine function, immunoregulatory capacity and multi-directional differentiation potential of stem cells. The cell spheres prepared by the method can be used for tissue repair, and especially show excellent repair effect in the treatment of thin endometrium.

The utility model discloses a visual female rabbit artificial insemination insemination gun belongs to female rabbit insemination field. A visual female rabbit artificial insemination insemination gun, include: handle, still include: probe pipe, fixed setting in the upper side of handle, baffle ring, set up in the end of probe pipe, probe head, set up in the probe pipe, and the probe head is close to the upper side of probe pipe inner wall, micropump machine, set up in the handle, draw liquid pipe, set up between the draw liquid end of baffle ring and micropump machine, storage bottle, set up in the lower side of handle, liquid discharge pipe, set up between the liquid discharge end of storage bottle and micropump machine, button, set up in the handle, the utility model effectively carries out the cleaning to mucus, and female rabbit is more easily accepted to relative to the mode of air blowing, and convenient operation personnel real -time observation insemination position, facilitate observation endometrium state, exclude female rabbit who suffers from endometritis or vaginitis, improve female rabbit conception rate.

This invention discloses an information processing method for TCM-assisted diagnosis and treatment of endometrial lesions. The method first fuses time-series hysteroscopic images, TCM four diagnostic methods, and clinical indicators to construct a dynamic graph sequence. By using phantoms as analysis units, multi-dimensional features encoding local interactions, lesion propagation, internal co-evolution, and sudden events are generated. Learnable weights are used to fuse these features, and intra-group and inter-group attention calculations are performed using a Token-Group Transformer to capture long-term temporal dependencies. Finally, anomaly scores are obtained by calculating the Mahalanobis distance between the phantom representation and the normal distribution. These scores are compared with clinical thresholds to output endometrial lesion classification information as auxiliary diagnostic and treatment information. This invention effectively integrates multimodal heterogeneous data, reduces dependence on labeled data, and improves the processing capability and efficiency of medical and health data for atypical lesions.

This invention relates to the field of biomedical technology and discloses an exosome preparation for treating thin endometrium and its preparation method. The preparation method includes the following steps: Step 1, culturing mesenchymal stem cells; Step 2, extracting exosomes; Step 3, preparing a collagen solution; Step 4, preparing traditional Chinese medicine components; Step 5, stirring the collagen solution and sheep placenta powder extract evenly at 4°C, then adding the exosome solution and mixing, then adding soy isoflavone solution and excipients, and after sufficient reaction, obtaining an exosome gel, which is then stored at 4°C. This invention utilizes the above-mentioned exosome preparation for treating thin endometrium and its preparation method, using collagen gel as a sustained-release matrix to provide three-dimensional structural support for the active substances, slowing down their degradation. Simultaneously, the growth factors in the sheep placenta powder extract work synergistically with the exosomes to activate angiogenesis, improve blood supply, and promote endometrial regeneration.

The present invention relates to a method for determining the state of the endometrium using a sample from a subject, for example, a plasma sample, and includes: (a) obtaining a sample from a subject or using a sample obtained from a subject, where the miRNA expression profile includes the expression levels of multiple miRNAs; and (b) analyzing the miRNA expression profile using a computer-based machine learning model to obtain a predictive score.

This invention provides a drug for preventing and treating intrauterine adhesions and its application, belonging to the field of biomedical technology. The drug comprises a pharmaceutically acceptable carrier and enhanced mesenchymal stem cells treated with a specific pretreatment culture medium. The pretreatment culture medium contains a stimulating component composed of Panax notoginseng saponin R1, melatonin, and tartary buckwheat polypeptides added to the basal culture medium. Through the significant synergistic effect of the combined use of these three components, this invention effectively enhances the tolerance of mesenchymal stem cells to the hypoxic-hypoglycemic microenvironment and strengthens their paracrine function. Experimental results show that these enhanced stem cells can significantly downregulate fibrosis markers such as α-SMA and COL1A1, inhibit the process of endometrial fibrosis, and significantly increase endometrial thickness and glandular number, promoting structural reconstruction and functional repair of damaged endometrium, providing a highly effective new drug regimen for the clinical treatment of intrauterine adhesions.