276 results about "Biopsy" patented technology

The invention relates to the technical field of medical image processing, in particular to a gynecological endoscope image intelligent analysis and cervical lesion precise diagnosis system. Comprising an image enhancement module, a differential geometric feature extraction module, a topology preserving manifold learning module, a curvature-blood vessel correlation analysis module, a biopsy point accurate positioning module, a real-time intelligent auxiliary diagnosis module, a clinical feedback module and a self-adaptive optimization module. Micro morphological change features are extracted through multi-scale curvature analysis; a topology sensitive encoder and a manifold alignment decoder are adopted, and a key topology structure is kept; establishing a correlation model of the tissue surface curvature change and the blood vessel morphology, and analyzing differential morphological characteristics; determining an optimal biopsy position based on the comprehensive characteristics; according to the method, the diagnosis result and basis are generated, visual display is provided, the detection rate of cervical lesions, especially early minimal lesions, is remarkably increased, the missed diagnosis rate is reduced, and multi-point biopsy is reduced.

Proposed is a method, apparatus, and system for providing medical diagnosis assistance information showing whether a tissue related to a tissue image is normal or abnormal (e.g., cancer) using the AI technology. Proposed are a method, an apparatus, and a system for training an AI model for producing medical diagnosis assistance information in consideration of conditions for obtaining a tissue image in an endomicroscope system for digital biopsy.

The present invention provides an elongated member for positioning a medical device at a target site within a body lumen. [Solution] The elongated member may include one or more articulated joints for maneuvering, one or more transducers for positioning, and one or more lumens for delivering the instrument to a target site. Some embodiments, in particular, relate to medical devices that guide an operator to a target site, confirm the location of the target site, enable a biopsy to be taken from the target site, and / or deliver treatment to the target site. For example, a position tracking sensor may be used to guide the medical device to the target site, a phased array sensor may be used to confirm proper positioning at the target site, and a biopsy needle inserted through a lumen may be used to take a sample from the target site.

Biopsy caps and seals, and methods for making and using the same may be provided in conjunction with an endoscope assembly. A seal may include a main body including a circumferential outer wall surrounding a central lumen. The seal may include at least one support wall extending radially from the outer wall towards a center of the lumen, and at least one helical flap extending from the support wall helically downward along an inner surface of the outer wall, where the at least one helical flap defines an opening at the center of the lumen. The seal may alternatively include a plurality of projections extending radially inward from the outer wall towards a center of the lumen, where the plurality of projections are arranged in a series of circumferentially and angularly offset layers.

The application discloses a single-cell biopsy and dynamic transcriptome tracking system and method, and belongs to the technical field of single-cell sequencing. The system comprises the following steps: culturing single cells to be detected in a cell culture dish; puncturing the single cells by using an amino-modified quartz nanocapillary to extract trace cytoplasm samples; recovering the single cells in a culture environment; applying specific stimulation to the recovered single cells; at one or more time points after the stimulation is applied, puncturing the same single cells again by using the quartz nanocapillary to extract trace cytoplasm samples, and recovering the single cells after each extraction; and respectively performing reverse transcription, amplification, library construction and sequencing on the cytoplasm samples extracted at different time points to obtain dynamic transcriptome data of the single cells at different time points. The application can perform low-damage multiple longitudinal biopsies on the same single living cell, and can construct a dynamic transcriptome atlas of the single cell on a time axis in combination with downstream sequencing.

The application discloses a kind of disease data analysis intelligent chip and system based on multi-modal molecular marker, it is related to disease data processing technical field.The intelligent chip includes: molecular marker image acquisition pre-evaluation module;Molecular marker image generation eligibility evaluation module;Multi-modal molecular marker data eligibility evaluation module.The intelligent chip is in the process of multi-modal molecular marker data analysis, after executing molecular marker image acquisition pre-evaluation eligibility, molecular marker image generation eligibility evaluation is executed, after molecular marker image generation eligibility evaluation eligibility, multi-modal molecular marker data eligibility evaluation is executed, reaches the effect of improving the accuracy of molecular marker disease image group data analysis, solves the problem of low accuracy of molecular marker disease image group data analysis caused by uneven thickness of kidney biopsy frozen tissue section in the prior art.

The present disclosure provides methods of amplifying tissue samples derived from humans for purposes of treating certain diseases. The method comprises: isolating a small amount of associated tissue by biopsy or other tissue acquisition methods; the tissue is amplified in vitro, and meanwhile, natural functions are reserved; and re-implanting the amplified tissue to alleviate human disease. One example includes ex vivo expansion of human pancreatic islet tissue and reimplantation of the expanded cells into an individual with Type 1 diabetes for treatment and long term relief or cure of disease.

The application relates to an image-based marrow component segmentation method and system, comprising the following steps: acquiring an original marrow biopsy digital image and preprocessing, obtaining a hematopoietic cell tissue and bone trabecula Mask mask image based on the preprocessed image; based on the original marrow biopsy digital image, sequentially performing color channel conversion, morphological open operation, isolated point elimination and hole filling to obtain a bone trabecula Mask mask image; based on the preprocessed image, obtaining a fat cell tissue Mask mask image according to the morphological characteristics of fat cells; and according to the obtained bone trabecula Mask mask image, the bone trabecula and hematopoietic cell tissue Mask mask image and the fat cell tissue Mask mask image, obtaining the area proportion of the bone trabecula, the hematopoietic cell tissue and the fat cell tissue in the original marrow biopsy digital image in each image.

The invention relates to the field of biomedicine, and discloses an expiration marker combination for diagnosing oral squamous cell carcinoma as well as application and a screening method of the expiration marker combination. Wherein the expiration marker combination comprises 29 oral expiration markers, a scoring model is constructed through the relative content of VOC signals of the expiration markers, the scoring model can be used for evaluating the oral squamous cell carcinoma risk of a patient, and the invention further discloses a screening method of the expiration marker combination. According to the screening method, a multi-algorithm feature union set strategy is adopted, the algorithm advantages of UTest, Boruta, LGBM, RF and the like are integrated, the limitation of a single algorithm is overcome, and the OSCC related expiration markers are recognized to the maximum extent. The core marker screening basis is clear, the PTR-TOF-MS detection process is standard, an interpretable verification mechanism is constructed, clinical popularization is facilitated, invasive biopsy dependence is reduced, diagnosis efficiency and patient compliance are improved, and important clinical and social values are achieved.

The present invention provides a method of reducing the likelihood of a subject having graft versus host disease or a method of treating graft versus host disease in a subject comprising analyzing a gastrointestinal biopsy of the subject to measure the number and density proportion of cells and administering to the subject a pharmaceutically effective amount of one or more immunosuppressive agents.

This invention provides a method, device, and equipment for preoperative risk stratification assessment of endometrial cancer. It involves segmenting and annotating preoperative ultrasound images to extract radiomics feature vectors, and simultaneously performing structured encoding and mapping of pathological biopsy data to generate pathological feature vectors. These two feature vectors are then input into a fusion network containing a cross-modal attention gating module. This gating module automatically generates dynamic weight vectors based on the consistency between the image and pathological features. The two feature vectors are then weighted and modulated separately before being concatenated to obtain a joint feature representation. This automatically reduces the weight of the lower-confidence modality and amplifies the weight of the higher-confidence modality when their assessment conclusions are inconsistent. Finally, the joint feature representation is input into a multi-task prediction network to output the probability of myometrial invasion depth and the probability of lymph node metastasis risk, thereby generating preoperative risk stratification results and surgical plan recommendations.

The invention relates to the technical field of medical instruments, and discloses a visual biliary tract rotary cutting biopsy expansion system assembly which comprises a conical sleeve, a visual mechanism is fixedly connected to the interior of the conical sleeve, a holding mechanism is installed on the left side of the visual mechanism, a rotary cutting mechanism is installed at the left end of the holding mechanism, and the visual mechanism comprises a cable. The exterior of the cable is fixedly connected to the interior of the conical sleeve, the top end of the cable is fixedly connected with a golden finger, the left end of the conical sleeve is fixedly connected with a protection assembly, the left end of the protection assembly is fixedly connected with a Luer lock cap, and the interior of the protection assembly is fixedly connected with an insertion pipe; a light source is fixedly connected into the protection assembly. The inside of the biliary tract is uniformly and sufficiently illuminated through the light source, a clear observation view is provided for a doctor, the doctor can accurately judge the illness state, and the situation that the positive rate of hepatopathic bile duct malignant stenosis biopsy is not high is reduced.

This disclosure describes how to treat and / or improve pancreatic cancer using a novel proteomic profile of the pancreatic cancer. In some embodiments, the treatment includes removing cancerous tissue after taking a biopsy from the patient. Optionally, the treatment includes administering anticancer agents to suppress the progression of pancreatic cancer. In further or alternative embodiments, the novel proteomic profile is used to monitor disease progression or remission.

The biopsy assembly comprises a cap body and a sampling piece, the cap body is provided with a first opening and a second opening, the first opening and the second opening are arranged in a staggered mode, a containing cavity channel and a pressure adjusting cavity channel are arranged in the cap body, the containing cavity channel is communicated with the first opening, and the pressure adjusting cavity channel is communicated with the second opening. The pressure adjusting cavity channel is communicated with the second opening and the storage cavity channel so as to provide positive pressure or negative pressure into the storage cavity channel; the sampling piece is at least partially arranged in the accommodating cavity channel and can move between a first position and a second position relative to the first opening; when the positive pressure in the containing cavity exceeds a first threshold value, the sampling piece moves from the first position to the second position relative to the first opening, so that at least part of the sampling piece penetrates through the first opening and extends out of the cap body. According to the utility model, the biopsy component and the intracavitary detector can be inserted into a cavity or an instrument channel at the same time after being matched, so that the sampling is prevented from deviating from the actual position, and the sampling accuracy is improved.

Apparatuses and methods for recovering solid tissue and dislodged cells ("D-cells") from a biopsy are disclosed herein. In an embodiment, a biopsy container apparatus for recovering solid tissue and D-cells from a biopsy includes a receiving container and a sieve container. The receiving container has a receiving chamber with an upper opening and a watertight bottom surface. The sieve container is configured to be located at least partially within the receiving chamber and removed from the receiving chamber through the upper opening. The sieve container has a bottom sieve surface including a plurality of apertures configured to pass the D-cells from the biopsy but not the solid tissue from the biopsy into the receiving chamber after the solid tissue and the D-cells from the biopsy are placed into the sieve container.

Apparatuses and methods for using augmented / mixed reality in surgical settings are provided, and, in particular, apparatuses and methods for intraoperative integration of augmented / mixed reality 3D models with near real-time pathology results. Real-time pathology results are generated using a machine learning analysis of biopsy pathology images in conjunction with a predictive model based on the patient's clinical and demographic data and radiographic imaging data. The apparatuses and methods can be used to provide more accurate intraoperative visualization, tracking, and determination of tumor margins to improve resection extent and any intraoperative or postoperative adjuvant therapy.

An actuator device comprises first, second and third actuators operatively connected to a biopsy needle arrangement comprising a needle inside a sheath. The needle arrangement has a closed state and an open state, a tip portion abutting a needle sheath in the closed state, and the tip portion extending from the distal end of the needle sheath in the open state. The first actuator pushes the needle distally in a sliding direction x relative to the needle sheath a first distance, d1, at which the needle arrangement is in its open state. The second actuator pushes the needle sheath distally in the sliding direction x relative to the needle a second distance, d2. The third actuator pushes the needle sheath distally in the sliding direction x relative to the needle a third distance, d3, where d3 is smaller than d2, at which the needle arrangement is in its closed state.

One or more devices, systems, methods and storage mediums for performing medical procedure (e.g., needle guidance, ablation, biopsy, etc.) planning and / or performance, and / or for performing registration using at least one mask, are provided. Examples of applications for such devices, systems, methods and storage mediums include imaging, evaluating and diagnosing biological objects, such as, but not limited to, lesions and tumors, and such devices, systems, methods and storage mediums may be used for radiotherapy applications (e.g., to determine whether to place seed(s) for radiotherapy). The devices, systems, methods and storage mediums provide improved registration results by utilizing at least one mask to suppress one or more artifacts or objects (which may or may not include, but is not limited to, at least one medical instrument or tool) in an image including a portion of the medical guidance device and / or to enhance a region or target of interest in the image.

This invention relates to a biopsy needle for trabecular meshwork tissue of the eye, belonging to the field of medical device technology. It solves the problem of large incisions caused by the large surgical incisions in traditional trabeculectomy procedures, where a scalpel is used to cut a block of ocular tissue containing the trabeculae and deep cornea and sclera. The invention includes a needle, a scraper unit, and a handle. The needle is connected to the handle, the scraper unit is disposed within the needle, and the handle is for the user to hold. The needle is inserted into the patient's eyeball, and the scraper unit is used to cut the trabecular meshwork and Schlemm's canal wall tissue. The scraper unit of this invention is a bendable scraper unit. The first, second, and third sections can form grooved hooks for hooking the trabecular meshwork and Schlemm's canal wall tissue. The grooved hooks of this invention are specifically designed to hook the trabecular meshwork and Schlemm's canal wall tissue, resulting in minimal trauma to the ocular incision.

The present disclosure provides, among other things, a method of isolating and expanding gamma delta (γδ) T cells, wherein the method comprises: (a) isolating non-hematopoeitic tissue by biopsy or explant, and (b) culturing the isolated non-hematopoeitic tissue in the absence of a three-dimensional scaffold or grid, thereby expanding and isolating gamma delta (γδ) T cells.

The utility model discloses a biopsy puncture device, and belongs to the technical field of medical instruments.In the biopsy puncture device, a limiting piece is arranged on a second component, and the limiting piece is used for limiting a first component, so that the first component can drive the second component to move towards a third component; the guide pipe is connected with the second component, so that the guide pipe can move along with the second component; the puncture needle can be connected with the first component, so that the first component drives the puncture needle to move when moving, the catheter can be driven to penetrate through the tissue together when the puncture needle punctures, the puncture needle can be withdrawn, the catheter is left in the tissue for subsequent operative treatment, and damage to the tissue in an operation is reduced.

The breast biopsy tissue collecting and cleaning warehouse comprises 12 collecting cells and an outer warehouse. The outer warehouse is provided with 12 sub-grades, and the 12 collecting cells are respectively arranged in the 12 sub-grades. One end of the collecting cell is provided with an entrance for the biopsy tissue to enter the inside of the collecting cell. A long hole is formed in one side of the collecting cell for the biopsy tissue to be taken out from the inside of the collecting cell. The outer warehouse is provided with a plurality of cleaning ports for spraying cleaning liquid into the inside of the collecting cell to clean the biopsy tissue. The single tissue cut by rotation can be directly transported into the collecting cell in the collecting warehouse. The flushing function of the collecting warehouse can be used to flush the tissue clean. The risk that the single tissue is excessively contacted and adhered due to being concentrated together to damage the integrity of the tissue is avoided. The tissue does not need to be flushed again, the use steps of the medical staff are reduced, and the efficiency is greatly improved.

This invention relates to an MRI-based method for classifying benign and malignant intraductal lesions (IDLs) of the breast, comprising the following steps: Step 1) Extracting a set of clinical features from MRI images: age, ADC value, BI-RADS category, lesion shape, margin clarity, and TIC curve type; Step 2) Extracting radiomics features from the 3D lesion segments of the T1 DCE-MRI sequence; Step 3) Reducing the dimensionality of the radiomics features using the Lasso algorithm; Step 4) Fusing the dimensionality-reduced radiomics features with the clinical features into an input vector; Step 5) Outputting benign / malignant probability values ​​through a logistic regression model; Step 6) Applying stratification rules to BI-RADS 4A lesions: older patients or those with low ADC values ​​are marked as high-risk and biopsy is recommended; younger patients with high ADC values ​​are marked as low-risk and follow-up is recommended. This method solves the problem of current dynamic contrast-enhanced MRI's difficulty in accurately identifying BI-RADS categories, especially the BI-RADS 4A high-risk subgroup, thereby reducing missed diagnoses and over-biopsy. It is of urgent significance for overcoming the bottleneck of preoperative risk stratification in IPLs and guiding individualized clinical decision-making.

The invention belongs to the technical field of medical instruments, and particularly relates to a child digestive tract foreign matter flexible clamping device which comprises an endoscope body, a flexible pipe is fixed to one end of the endoscope body, and a biopsy channel is formed in the flexible pipe. The multi-form clamping module is assembled in the biopsy channel in a sliding mode, the multi-form clamping module comprises a forceps rod, a driving guide wire, a first forceps head, a second forceps head, a third forceps head and a fourth forceps head, and the forceps rod is assembled in the biopsy channel in a sliding mode. Through a dual-mode clamping structure of the V-shaped clamp type clamping unit composed of the first clamp head and the second clamp head and the parallel type clamping unit composed of the third clamp head and the fourth clamp head, clamping modes can be flexibly switched according to the shapes of foreign matters; the device can adapt to child alimentary canal foreign matters in various forms such as flat, regular, circular and irregular shapes, and the clamping application range is greatly expanded.

Processes and materials to detect cancer, transplant rejection, or fetal genetic abnormalities from a biopsy are described. In some cases, cell-free nucleic acids can be sequenced, and the sequencing result can be utilized to detect sequences indicative of a neoplasm, transplant rejection, or fetal genetic abnormality. Detection of somatic variants occurring in phase and / or insertions and deletions (indels) can indicate the presence of cancer, transplant rejection, or fetal genetic abnormalities in a diagnostic scan, and a clinical intervention can be performed.

Disclosed are methods for detecting and treating cancers (such as carcinoma, leukemia, lung cancer, colon cancer, central nervous system (CNS) cancer, melanoma, ovarian cancer, renal cancer, oral cancer, prostate cancer and / or breast cancer). The method may include receiving a sample from a patient (such as a sample from a biopsy, a sample from an extracellular vesicle, or a sample from a circulating tumor cell). The method may include determining whether a LY6C protein or a phosphorylated ANXA2 protein is detected in the sample. The method may include treating a patient for cancer by targeting the LY6C protein when the LY6C protein is detected (e.g., using photoimmunotherapy (PIT) or near infrared photoimmunotherapy (NIR-PIT)). or treating a patient for cancer by targeting an ANXA2 protein (e.g, using inhibitors, decoys, etc.) when the phosphorylated ANXA2 protein is detected.

A biopsy cap can be operably connected to a port of a medical device. The biopsy cap seals a working channel configured to allow devices of different diameters to pass through. During endoscopic procedures, the tips of many devices, such as guidewires and catheters, can be moistened before use to avoid excessive drag when inserting the device through the working channel of the endoscope. The cap system comprises a cap for the port of a first medical device and a wetting device connected to a portion of the cap and configured to moisten a second medical device passing through the cap system.

The invention relates to a multifunctional capsule robot integrating dual-channel biopsy, drug administration and anchoring functions, which comprises a shell, a capsule, a capsule, a capsule and an anchoring device, wherein a bracket is arranged in the shell; the three-degree-of-freedom magnetic driving assembly is arranged on the bracket, and the three-degree-of-freedom magnetic driving assembly is arranged on the bracket; the tool switching mechanism is used for switching different tool cabins, and the tool switching mechanism is installed on the support; the four tool cabins respectively have the functions of 30G biopsy, 25G biopsy, drug A administration and drug B administration, are used for supporting the realization of double-channel biopsy and double-channel administration, and are mounted on a four-phase tool wheel disc of the tool switching mechanism; and the deformation anchoring mechanism is used for being fixed near a focus, and the deformation anchoring mechanism is connected with the support. The device is used for diagnosis and treatment of human body lumen organs such as digestive tracts, is suitable for multi-part tissue sampling, multi-drug precise administration and stable anchoring operation under the non-invasive or minimally invasive condition, realizes function cooperation through the four-phase tool wheel disc, and flexibly switches the working state between two-channel biopsy and drug administration; and an integrated solution is provided for diagnosis and treatment of intracavity diseases.

A system and method for navigation of a luminal network including receiving a computed tomography (CT) image data set, generating a three-dimensional (3D) model, displaying the 3D model in a user-interface on a display operatively connected to the computing device, and receiving an indication of a location of a tumor in the CT image data set. The system and method further including displaying the location of the tumor in the 3D model, receiving an indication of a margin around the tumor to achieve a desired therapy, generating a pathway to the tumor for navigation of a catheter, receiving a location of a sensor associated with a navigation catheter and registering the CT image data set with a luminal network of a patient, displaying the location of the sensor within the 3D model that substantially corresponds to the location of the sensor within the luminal network of the patient.

The utility model belongs to the technical field of medical equipment, and discloses a sampling robot, which comprises: a shell, the shell defines an accommodating cavity, the shell is provided with a communicating hole, and the communicating hole communicates the accommodating cavity with the exterior of the shell; the multiple liquid pumping devices are arranged in the containing cavity, and each liquid pumping device is provided with a liquid pumping opening; the rotation driving part is arranged in the containing cavity, the rotation driving part is connected with the multiple liquid pumping devices, and the rotation driving part is used for driving the multiple liquid pumping devices to rotate to the positions where the liquid pumping openings face the communicating holes, so that the multiple liquid pumping devices sample from the communicating holes. The technical problem that the intestinal juice biopsy capsule robot needs to be put into a human body for multiple times when performing biopsy liquid taking at different positions can be solved.