307 results about "Stroke" patented technology

The invention discloses a multi-priori knowledge fused cerebral apoplexy rehabilitation map convolutional network evaluation method, and belongs to the technical field of cerebral apoplexy rehabilitation evaluation. Firstly, a high-precision prior information matrix is automatically generated through a collaborative and causal relationship automatic reasoning method based on Riemannian manifold geometry and transfer entropy, the problem that in the prior art, engineering depends on artificial features is effectively solved, and interpretable physical prior guidance is provided for a model. Then, through a multi-relation graph construction and attention weighting multi-modal adaptive fusion method, spatio-temporal features and priori knowledge are adaptively fused, an optimized graph structure is constructed, and the representation ability and interpretability of the model to complex joint interaction are improved. And finally, through a space-time diagram convolutional network guided by prior information and a comparative learning collaborative optimization method, the generalization ability and evaluation precision of the model in a small sample scene are remarkably improved through data enhancement and loss function optimization.

The invention discloses a stroke hand rehabilitation training method based on multi-modal data fusion, particularly relates to the field of hand rehabilitation training, and is used for solving the problems that in the existing rehabilitation process, the motion solidification risk cannot be recognized, and the training scheme is lack of individualized dynamic adjustment. According to the method, hand joint motion features are obtained by constructing a standardized hand function micro-evaluation task, and a personal motion mode baseline is established in combination with dynamic time warping and multi-scale permutation entropy analysis; extracting a neural motion curing index based on the difference change between the current motion mode and the optimal motion mode, and analyzing and generating a function recovery momentum feature by combining the rehabilitation progress gradient and the acceleration inflection point; and fusing the electromyographic signal coupling coordination index to generate a rehabilitation risk score, and when the risk exceeds a dynamic threshold value, triggering adaptive recombination of a training strategy to realize accurate early warning and personalized training regulation and control. Rehabilitation monitoring precision and training pertinence can be effectively improved, and high-quality recovery of stroke hand functions is promoted.

The invention discloses a preparation method of artemisia apiacea extracellular vesicles, which comprises the following steps: step 1, pre-treating artemisia apiacea, carrying out primary centrifugal treatment, removing large plant tissues and cell debris, carrying out secondary centrifugal treatment, filtering by a needle filter, and collecting; step 2, transferring the filtered suspension to a sucrose density gradient solution, then carrying out third centrifugal treatment, collecting the solution with the concentration of 30% in the layer, and carrying out fourth centrifugal treatment to obtain artemisia apiacea extracellular vesicles; the invention further discloses an artemisia apiacea extracellular vesicle, a pharmaceutical composition for treating cerebral apoplexy, a medicine and application of the artemisia apiacea extracellular vesicle in preparation of the medicine for treating cerebral apoplexy. The naturally-sourced vesicle delivery system provided by the invention is expected to have higher safety and lower toxic and side effects, and the enrichment concentration of the therapeutic component at the focus part of cerebral apoplexy is improved, so that the bioavailability and the treatment efficiency of the medicine are remarkably improved.

The invention discloses a severe heatstroke gait pre-training method based on rising bed angle dynamic optimization, and relates to the technical field of rehabilitation medical instruments.The severe heatstroke gait pre-training method comprises the following steps that a patient is safely fixed to an electric rising bed and connected with multi-modal physiological signal monitoring equipment, and a patient examination result is obtained; the central processing unit receives the collected initial data and initializes setting of angle parameters of the standing bed; the electric standing bed is controlled to lift the tentative angle and maintain the tentative angle, and all physiological signal data are collected and recorded; in the standing bed angle maintaining process, physiological signal data flow is obtained, physiological data are input into the tolerance prediction model, and a tolerance index is obtained; according to the tolerance index value, the tolerance level of the patient is judged, and different bed rising instruction operations are executed; the real-time data acquisition process, the tolerance index calculation process and the angle adjustment decision making process are repeatedly executed until the end; after training is finished, a training report is generated, and all data are encrypted and stored in a database.

The invention relates to the technical field of medical instruments, in particular to an ice stimulation training device for dysphagia rehabilitation, which comprises a box body with an upward opening, a cover plate arranged at the opening of the top of the box body, two partition plates arranged in an internal cavity at an interval up and down, and an auxiliary opening mechanism arranged in a training opening in the front side of the box body and used for opening the box body. An ice stimulation training head is arranged in the ice stimulation training device, the tail of the ice stimulation training head is connected with a control mechanism, and a pneumatic assembly is arranged on the left side of the top of the partition plate on the upper side and connected with the auxiliary opening mechanism through an air pressure rod assembly. The problems that in the prior art, an ice stimulation training device for rehabilitation of the stroke dysphagia generally can only achieve single ice stimulation treatment and lacks auxiliary taste stimulation and vibration stimulation for comprehensive treatment, so that the whole treatment process is long in time, more complex and free of cooperation, and the treatment cost is low are solved. Meanwhile, the compliance of the patient and the recognition degree of treatment are also reduced, and the patient cannot recover as soon as possible.

The invention provides an application of a super enhancer inhibitor JQ-1 in preparation of peripheral artery disease related drugs, relates to the technical field of biomedicine, and discloses a core effect of the super enhancer inhibitor JQ-1 in peripheral artery disease ischemia repair. The traditional Chinese medicine composition can significantly accelerate blood flow recovery of ischemic limbs, up-regulate mRNA and protein expression of a vascular marker CD31 in gastrocnemius muscle tissues, effectively increase vascular density and promote angiogenesis. Aiming at the defects of the existing treatment means in the aspect of ischemic tissue angiogenesis, the application provides a brand new molecular targeted treatment scheme for high-risk groups such as patients with diabetes-related peripheral artery diseases, and can significantly reduce the risk of lower limb amputation and the incidence rate of related cardiovascular adverse events such as coronary heart disease and stroke; the technical blank of specific targeted therapy of peripheral artery diseases is filled, a solid scientific basis and a key direction are provided for research and development of novel drugs, and the specific targeted therapy method has extremely high clinical application value and wide research and development prospects.

The invention relates to the technical field of brain function network analysis, in particular to a post-stroke aphasia patient fMRI focal recognition method based on deep learning. The method comprises the following steps of: acquiring a region consistency value for geometric structures of matched local regions of two adjacent fMRI images in an fMRI image sequence, similarity of gray distribution and an image matching degree, and dividing a same time window by using the region consistency value; and obtaining a functional connection coefficient according to the difference of the region consistent values of the fMRI images in two adjacent time windows and the difference of the geometric structure features and the gray level distribution features of the local regions, determining the convolution kernel size of deep learning of the fMRI images in the time windows by using the functional connection coefficient, and performing focal recognition on the fMRI images in the time windows. According to the method, the function connection coefficient presenting the cooperation degree of the brain region activity modes in the adjacent time windows is analyzed, the convolution kernel size of the time windows is determined in a self-adaptive mode, and the recognition effect on the local focus of the patient is improved.

The present invention relates to the use of Antithrombin in the treatment of stroke.

The invention discloses application of traditional Chinese medicine monomer poplar bud flavin (including homologues thereof and extracts / mixtures containing the same) in preparation of drugs for treating nerve injury diseases and a preparation method of the drugs for treating the nerve injury diseases. The pharmacological action mechanism of the monomer poplar bud flavin is deeply explored, and animal model application effect verification proves that the monomer poplar bud flavin (including homologues thereof and extracts / mixtures containing the homologues) can obviously improve core symptoms of cerebral apoplexy, autism, Alzheimer's disease and depression models, is high in safety, and can be used for preparing a medicine for treating cerebral apoplexy, autism, Alzheimer's disease and depression models. The invention also develops a medicine for treating cerebral apoplexy, autism, Alzheimer's disease and depression, which takes the poplatin as a core component (including homologues of the poplatin and extracts / mixtures containing the poplatin), and is expected to provide new research results and application schemes for treatment of nerve injury diseases such as cerebral apoplexy, autism, Alzheimer's disease, depression and the like. The important significance is realized on improving the treatment effect.

The utility model discloses a hand rehabilitation training exoskeleton, and relates to the technical field of exoskeletons. According to the hand rehabilitation training exoskeleton, the ends of the palm shells are connected with the joints in a supporting mode through supporting sleeves, and the supporting sleeves are connected with an air conveying device in a communicating mode. The carpal joint is connected with the palm shell through a supporting sleeve, the other end of the carpal joint is connected with the metacarpal joint or the finger joint through the supporting sleeve, and the other end of the metacarpal joint is connected with the finger joint through the supporting sleeve. The problems that in the prior art, the size is large, flexibility is poor, operation is complex and the like are solved, and the requirements for precise assistance and natural training are difficult to meet. According to the hand rehabilitation training exoskeleton, the exoskeleton and the pneumatic technology design are combined, the lightweight design and the intelligent control technology are combined, the hand rehabilitation training exoskeleton aims at assisting a hand dysfunction patient in scientific rehabilitation training, and the hand rehabilitation training exoskeleton is suitable for stroke, brain injury, joint diseases or postoperative hand function recovery. Natural assistance and scientific rehabilitation of hand movement are achieved, and an efficient and safe hand function recovery means is provided for a patient.

The invention relates to the technical field of medicines, in particular to application of a mesenchymal stem cell exosome in preparation of a thermoplegia neuroprotective agent. It is found through experiments that MSC-Exos can remarkably promote polarization conversion of microglial cells from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, and therefore damage, caused by heat stroke, to a central nervous system is relieved.

The present invention relates to a system and method configured for analysing acoustic parameters of speech to detect, diagnose, predict and / or monitor progression of a condition, disorder, or disease, and more particularly, any of paediatric and adult neurological and central nervous system conditions including but not limited to low back pain, multiple sclerosis, stroke, seizures, Alzheimer's disease, Parkinson's disease, dementia, motor neuron disease, muscular atrophy, acquired brain injury, cancers involving neurological deficits, paediatric developmental conditions and rare genetic disorders such as spinal muscular atrophy. The system and method extracts a first formant data set from words spoken by an individual and uses these to classify the vowels in the words on a first computing device, such as a mobile smart phone equipped with a microphone into which an individual speaks. The system stores at least some of these frequencies for the vowel formants in a second formant data set as a recorded file and provides the second formant data set as input to acoustic metrics to generate score data from which an assessment is made to determine the articulation level of the vowels in the words spoken by the individual, allowing allow for detection, diagnosis, prediction and / or monitoring progression of the condition, disorder, or disease.

The application discloses a kind of medicine packing information intelligent identification method and system, it is related to medicine packing information intelligent identification field, to improve the accuracy of medicine packing information identification, comprising: obtaining the image information of medicine packing;Extract multiple types of character information from image information;Multiple types of character information include character stroke structure, character texture and with character geometric contour;Determine the defect type and defect degree that exist in image information;According to defect type and defect degree, set the proportion of multiple types of character information;After setting proportion, multiple types of character information are integrated, and the preliminary comprehensive description of character is obtained;Context logical judgment is carried out to the preliminary comprehensive description of character, and the final comprehensive description of character is obtained;Context logical judgment uses pre-set format specification, production plan data and the association between characters to verify and correct identification result.

The embodiment of the present application provides an adjusting structure of a spinal surgery channel system and the spinal surgery channel system with the adjusting structure. The spinal surgery channel system comprises an endoscope and a working channel tube, the adjusting structure comprises a supporting assembly, an adjusting assembly and a matching seat, the supporting assembly is used for mounting the working channel tube, the matching seat is connectable with the endoscope, and the matching seat is swingably connected with the supporting assembly along a first preset direction through the adjusting assembly so as to realize the displacement of an endoscope tube of the endoscope along the first preset direction. Therefore, the relative position of the endoscope tube in the working channel tube is changed, the moving stroke range of the endoscope tube is improved, and the doctor can adjust the endoscope tube to the ideal position according to the actual situation of the patient. Therefore, the adjusting structure according to the embodiment of the present application has the advantages of improving the operation field of view and increasing the flexibility and convenience of the operation.

A medical system configured to detect and / or monitor one or more physiological parameters of the patient including an electroencephalogram (EEG) of the patient, a oxygen level of the blood patient (e.g., a jugular venous oxygen saturation (SjVO2)), and / or a blood flow of the patient (e.g., a cerebral blood flow). The medical system may include processing circuitry configured to monitor the physiological parameters and compare the physiological parameters to one or more thresholds. The medical system may be configured to indicate that the patient may have experienced a stroke based on the comparison of the physiological parameters with the thresholds. In examples, the processing circuitry is configured to indicate a type of stroke the patient may have experienced based on the comparison.

The utility model discloses a breathing pipeline device capable of adjusting and releasing airway pressure, which comprises a breathing sputum excretion device body, a fourth connector, an air valve main body, an adjusting assembly and a sputum excretion assembly, and the air valve main body is used for blocking or opening an airflow channel in the fourth connector; the sputum excretion assembly is used for providing an upward opening moving stroke for the air valve assembly, one end of the sputum excretion assembly is installed on the breathing sputum excretion device body, and the other end of the sputum excretion assembly is installed on the top of the air valve body. The adjusting assembly is arranged on the periphery of the breathing sputum excretion device body and the periphery of the sputum excretion assembly in a sleeving mode. The distance between the breathing sputum excretion device body and the sputum excretion assembly is adjusted through the adjusting assembly, and then the pressing force of the sputum excretion assembly for pressing the air valve assembly is adjusted; therefore, the breathing intensity of the patient during breathing training can be adjusted, and the device is suitable for breathing rehabilitation training of various moderate and mild patients in the lung department and contributes to expectoration of sputum.

The invention discloses a severe patient blood pressure trend monitoring and intervention decision-making system based on deep learning, and relates to the technical field of medical information processing, which comprises the following steps: acquiring a continuous invasive arterial pressure waveform and carrying out pulse-by-pulse segmentation, and extracting pulse-by-pulse average pressure and a multi-dimensional high-frequency waveform characterization quantity; and calculating a voltage-sharing deviation amount, a high-frequency retention amount and a steady-state collapse eigen index in combination with preorder analysis window data, inputting the data into a time sequence deep learning network to obtain a pseudo trend probability, further obtaining a corrected voltage-sharing slope and a real trend slope, respectively calculating a link checking priority and a real low-voltage intervention priority, and outputting an auxiliary intervention decision. According to the invention, link distortion and real blood pressure deterioration can be distinguished, and the accuracy of trend monitoring and intervention decision is improved.

A clip may be configured to close a portion of a heart to reduce blood flow therethrough and passage of clots or other undesirable materials. The clip may be configured to close a left atrial appendage (LAA). The closure of the LAA may reduce the likelihood of stroke or other disease caused by fluid flow with the LAA.

The present invention relates to chemical compounds useful as inhibitors of class II phosphoinositide 3-kinase (PI3K) signaling. The invention further relates to the medical use of inhibitors of class II phosphoinositide 3-kinase (PI3K) signaling in the treatment of medical conditions associated with defective and / or pathological class II phosphoinositide 3-kinase (PI3K) signaling, such as stroke, cardiovascular diseases associated with endothelial cell dysfunction, cancer, cancerometastasis, myopathy and diabetes.

The invention relates to a crystal form of a compound shown as a formula I or a pharmaceutically acceptable salt thereof and a preparation method of the crystal form of the compound shown as the formula I or the pharmaceutically acceptable salt thereof. The compound of the formula I or the pharmaceutically acceptable salt thereof is used for treating cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, heart failure, pulmonary arterial hypertension (WHO levels I, II, III, IV), angina pectoris, thrombus, restenosis, myocardial infarction, stroke, cardiac insufficiency, fibrosis, pulmonary hyperplasia, erectile dysfunction, asthma, chronic kidney disease, diabetes, and the like. The composition can be used for treating liver cirrhosis, chronic obstructive pulmonary disease (COPD), acute respiratory distress syndrome, acute lung injury, pulmonary fibrosis, cystic fibrosis or interstitial lung disease.

The present disclosure relates to 1-(2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)acetyl)-4- hydroxypyrrolidine-2-carboxamide derivatives and structurally related compounds of formula (I) as VHL inhibitors for the treatment of e.g. anemia (e.g. chronic anemia or anemia associated with chronic kidney disease, dialysis or cancer chemotherapy), ischemia, stroke or injury to the cardiovascular system during ischemia, or for enhancing wound healing, reducing scarring or enhancing angiogenesis or arteriogenesis.

A multimodal predicate diagnostic system for hospital stroke detection utilizes TEE-secured mobile devices to monitor patients in clinical environments. The system aggregates motion data using optimized sampling and cryptographic validation, applying a hybrid CNN-decision tree model optimized via transfer learning and data augmentation against an adaptive gait baseline. It computes risk confidence scores in real-time and generates alerts with hospital network integration.

The invention relates to the technical field of mechanical arm control methods, and discloses a muscle force evaluation and self-adaptive control method for a household remote control upper limb intelligent rehabilitation mechanical arm, which comprises the following steps: initializing a system, guiding the first elbow flexion by voice, and judging the anti-gravity capability according to an elbow joint flexion angle. Secondary elbow bending is carried out after different reverse resistances are applied, the resistance resistance is judged according to the elbow joint bending angle, a scale is converted into clinical muscle force classification, a main control board calculates self-adaptive traction force and realizes closed-loop control, meanwhile, whole-course data are uploaded to a cloud side, and remote terminal monitoring and parameter adjustment are supported; according to the invention, the evaluation logic conforms to the clinical standard, the detection precision is high, the system integration level is good, quantitative muscle force evaluation, individualized adaptive training and remote professional supervision can be realized, the system is suitable for household upper limb rehabilitation of stroke, nerve injury and postoperative patients, and the technical problems of inaccurate evaluation, fixed control and lack of remote management of existing equipment are effectively solved.

A system for component testing for head or brain injury criteria can include a vehicle seat that is substantially stationary. A dummy can be seated in the vehicle seat. The dummy can include a head and a body. An impactor can be substantially aligned with the head. An airbag can be located between the dummy and the impactor. The impactor can be caused to be projected toward a head of a dummy at a target energy, a target position, and / or with a target stroke.

The invention relates to novel liquid body temperature circulation temperature control equipment, and belongs to the technical field of medical temperature control equipment. The device comprises an equipment base, a temperature control host, a stand column, a T-shaped installation frame, a pipeline assembly, a temperature control assembly and a temperature sensing assembly, the stand column is fixedly installed above the equipment base, the temperature control host is installed on one side of the stand column, the T-shaped installation frame is fixedly installed above the stand column, a lifting hook is installed below the T-shaped installation frame, and the pipeline assembly is installed above the lifting hook. The temperature control assembly is fixedly installed on one side of the temperature control host, and the temperature sensing assembly is installed on one side of the lower portion of the temperature control host. The temperature control equipment monitors the pipeline output temperature and the core body temperature of a patient in real time through the temperature sensing assembly, the temperature control host adjusts the temperature control power in a closed-loop feedback mode based on monitoring data, accurate, rapid and stable temperature control is achieved, the equipment is suitable for various clinical scenes needing mild hypothermia intervention such as thermoplegia and the syndrome after cardiac arrest, treatment safety and effectiveness are improved, and the treatment cost is reduced. And the workload of medical staff is reduced.

The invention discloses a flow velocity controllable throat stimulation device adaptive to a stroke dysphagia patient, and relates to the technical field of throat stimulation devices. The flow velocity controllable throat stimulation device adaptive to the stroke dysphagia patient comprises a host, an electrode patch, a pinhole swallowing patch, a conductive joint and an electrode wire which are arranged on a swallowing electrical stimulator body, the side wall of the conductive joint is fixedly sleeved with an annular cover, and a sliding ring is slidably connected in the annular cover. According to the flow velocity controllable throat stimulation device adaptive to the stroke dysphagia patient, the pinhole dysphagia paste around the electrode paste can be stricken, bubbles can be scraped and exhausted, negative pressure can be generated in the rotating cover, the rotating cover can be adsorbed on the skin under the action of the negative pressure, and the flow velocity controllable throat stimulation device is suitable for the stroke dysphagia patient. The pinhole swallowing paste has the advantages that the pinhole swallowing paste is better in pasting effect with the skin, the pinhole swallowing paste is more stable and reliable, the electrode paste is better in pasting effect with the skin, and the use effect is better.

Sublingual or buccal dosage forms comprise at least one antioxidant compound, such as N-acetyl cysteine (NAC), or a pharmaceutically acceptable salt thereof. The sublingual or buccal dosage forms are administered for treating central nervous system (CNS) disorders, such as traumatic brain injury or stroke.

The invention relates to a compound which is effective in inhibiting the function of the TRPM4 ion channel and the use of such compound in treating or preventing a TRPM4-associated disorder in a subject such as neurodegenerative diseases like stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and neurodegenerative disease under inflammatory conditions, in particular multiple sclerosis, or genodermatosis, cardiac diseases, and immunemediated diseases. The invention also provides a pharmaceutical composition comprising the TRPM4 inhibitory compound.

Liposomal trans-crocetin pharmaceutical compositions, dosing regimens and methods of treating or preventing disorders and conditions associated with, but not limited to, infection, ischemia, hypoxia, ARDS, inflammation, sepsis, shock, stroke, traumatic injury, and proliferative disorders such as cancer are provided. Methods of using the provided trans-crocetin pharmaceutical compositions and dosing regimens to treat cardiovascular, renal, liver, inflammatory, metabolic, pulmonary, neurological, and other disorders and conditions are also provided, as are methods of increasing the delivery of oxygen and increasing the efficacy of a therapeutic agent using the provided compositions and dosing regimens.