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572 results about "Nitric oxide" patented technology

Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO. It is one of the principal oxides of nitrogen. Nitric oxide is a free radical, i.e., it has an unpaired electron, which is sometimes denoted by a dot in its chemical formula, i.e., ·NO. Nitric oxide is also a heteronuclear diatomic molecule, a historic class that drew researches which spawned early modern theories of chemical bonding.

Systems and Methods for Generating Nitric Oxide

Systems and methods for generating nitric oxide are disclosed. A nitric oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.
Owner:THIRD POLE INC

Small waste incineration full-automatic control system and method

The invention discloses a small waste incineration full-automatic control system and method, and particularly relates to the technical field of solid waste treatment.The method comprises the following steps that waste throwing is recognized through infrared induction, a preheating device is started to heat a combustion chamber, and the heating intensity is adjusted in real time; when the temperature reaches a preset threshold value, the air volume, the feeding time and the combustion time are controlled according to the garbage type, and stable combustion is achieved; the concentration of carbon monoxide, nitric oxide and particulate matter in tail gas is monitored in the whole process, and combustion parameters are automatically adjusted when the emission limit value is close; after combustion is finished, slag is automatically discharged according to the amount of slag; meanwhile, temperature and emission data are collected and uploaded to a remote terminal, and full-process intelligent control and environment-friendly management are achieved; the whole-process automatic control is realized, and the manual dependence is reduced; combustion efficiency and adaptability are improved through an intelligent model; an emission prediction and feedback mechanism is introduced to ensure that the tail gas is environmentally friendly and reaches the standard, and the system stability and the intelligent level are enhanced.
Owner:HUANGSHAN TIANZHIDU ENVIRONMENTAL SCI & TECH DEV CO LTD +2

Nitric oxide data analysis method and system for bronchial asthma assessment

The invention relates to a nitric oxide data analysis method and system for bronchial asthma assessment. According to the method, exhaled air nitric oxide and pulmonary alveolar nitric oxide of a patient, omics data and clinical information are acquired in a standardized manner, and multi-dimensional features are constructed after data cleaning and fusion; comprise an inflammation level index, an inflammation region entropy, an inflammation synergy index, a glucocorticoid response factor, an infection-smoking synergy influence factor and a heredity-symptom distribution index. And outputting initial risk assessment based on an explainable elevator EBM model, and finally generating an asthma risk probability through a weighted integration formula to realize three-level layering: low / medium / high risk. The system dynamically associates treatment decisions, for example, the drug dosage and the monitoring frequency are improved when the risk is upgraded, and the medication scheme is optimized when the risk is degraded. According to the scheme, the limitation of traditional single marker static analysis is broken through, multiple mechanisms of dissection, immunity and pharmacology are fused, the evaluation precision and clinical applicability are remarkably improved, the acute attack rate is reduced, and accurate typing treatment is guided.
Owner:FUDING CITY HOSPITAL

Method and system for reducing generation of nitrogen oxides in ammonia coal combustion process

The invention belongs to the field of pollutant control, and particularly discloses a method and system for reducing generation of nitric oxide in the ammonia coal combustion process. The method specifically comprises the steps that liquid ammonia is gasified and then subjected to a thermocatalytic reaction to generate hydrogen and nitrogen, and ammonia-doped mixed gas is obtained; and judging whether the ratio of the concentration of hydrogen to the concentration of ammonia in the ammonia-doped mixed gas is greater than or equal to a threshold value or not, if so, discharging the ammonia-doped mixed gas for blending combustion, and if not, carrying out thermal catalytic reaction on the ammonia-doped mixed gas again. According to the method, the ratio of the concentration of hydrogen to the concentration of ammonia in the ammonia-doped mixed gas serves as the judgment standard for whether blending combustion can be conducted or not, the calculation formula of the threshold value is provided by balancing the influence of H2 and NH3 on NOx generation in the combustion process, then flexible regulation and control can be conducted on the raw material side according to the actual blending combustion condition, and the blending combustion efficiency is improved. The method effectively reduces the generation of nitrogen oxides in the ammonia coal combustion process, does not need to regulate and control the combustion side, does not affect the combustion stability and the boiler thermal efficiency, and has the advantages of simple operation and low cost.
Owner:HUAZHONG UNIV OF SCI & TECH

Photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking as well as preparation method and application of photo-thermal controlled-release nitric oxide anti-biofilm hydrogel

The invention discloses photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking as well as a preparation method and application of the photo-thermal controlled-release nitric oxide anti-biofilm hydrogel based on click reaction crosslinking, the hydrogel is prepared by taking azide group-containing four-arm polyethylene glycol and alkynyl modified hyaluronic acid as matrixes through click chemistry rapid crosslinking under the catalysis of copper-based nanoparticles, the antibacterial biological membrane has remarkable dual anti-biological membrane and anti-inflammatory effects, and can be applied to wound treatment of bacterial biological membrane infection; through a wound surface coating form, under near-infrared light irradiation, copper nanoparticles generate a mild photothermal effect to remove a biological membrane, and Cu < 2 + > is released to promote fibroblast proliferation; nitric oxide can be controllably released, a biological membrane is synergistically eliminated by enhancing lipid peroxidation and destroying a bacterial membrane structure, meanwhile, angiogenesis is promoted, collagen deposition is stimulated, and the wound healing process is accelerated; the invention has the functions of efficient antibiosis and tissue regeneration, and has wide clinical application prospect and development value in the field of infectious wound treatment.
Owner:CHINA PHARM UNIV

CFB boiler flue gas denitration automatic control method and system

The invention discloses a CFB boiler flue gas denitration automatic control method and system. The control method comprises the following steps: S1, monitoring and controlling a CFB boiler by taking an operator station display as a center; s2, a nitrogen oxide emission value of a boiler tail flue in the CFB boiler is collected in real time to serve as a feedback value; s3, the feedback value is compared with a set target emission value, and the deviation value of nitric oxide at the flue gas outlet and the change rate of the deviation value are calculated; s4, constructing a fuzzy relation between the three PID parameters and the deviation and the change rate of the deviation value, and obtaining a new PID parameter; s5, the stroke of an ammonia water pump is dynamically adjusted according to the new PID parameters, and the amount of the urea solvent sprayed into the boiler is controlled; and S6, the stroke of a dilution water pump and the flow of dilution water are regulated and controlled. By means of early warning, control over spraying of the reducing agent and burdening in the boiler is achieved, it is guaranteed that the denitration system can change along with changes of the boiler operation load, and long-term, reliable and safe operation of boiler denitration is achieved.
Owner:HUBEI JUNYUN TECH CO LTD

Streptococcus suis type 2 gene deletion strain as well as construction method and application thereof

The invention discloses a streptococcus suis type 2 gene deletion strain as well as a construction method and application thereof, and belongs to the technical field of biological products. According to the invention, the B9H0105210 gene in the genome of the streptococcus suis serotype 2 SC19 is deleted in a homologous recombination manner for the first time, the hydrogen peroxide and nitric oxide stress resistance of the constructed streptococcus suis serotype 2 gene deleted strain is reduced, and the pathogenicity to mice is obviously weakened; moreover, the growth performance of the streptococcus suis type 2 gene-deleted strain is not greatly different from that of a wild strain SC19, the condition of gene recovery does not exist after continuous passage, and the streptococcus suis type 2 gene-deleted strain has an application prospect as an attenuated live vaccine, has a good immune protection effect on different genotypes of streptococcus suis such as the streptococcus suis type 2 strain SC19 and streptococcus suis type 2 P1 / 7, and has a good application prospect. And a certain cross immune protection performance is achieved.
Owner:SOUTHWEST UNIV

Temperature-sensitive hydrogel for cancer treatment capable of photothermal therapy and preparation method therefor

The present invention relates to: a temperature-sensitive hydrogel for cancer treatment; a photothermal composition comprising the hydrogel as an active ingredient; and a preparation method for the temperature-sensitive hydrogel for cancer treatment. The temperature-sensitive hydrogel of the present invention includes gold nanostars as active ingredients, and thus can generate heat by light irradiation, thereby exhibiting a photothermal therapy effect. In addition, the hydrogel temperature increases so that the release of nitric oxide (NO) from S-nitrosocysteine can be induced. In addition, the temperature-sensitive hydrogel of the present invention includes S-nitrosocysteine as an active ingredient so that, upon a temperature rise due to a photothermal reaction, the penetration of drugs into a tumor site can be improved by the release of NO, and at the same time, apoptosis of cancer cells can be directly caused; and includes an immunotherapy agent as an active ingredient so that tumor size can be effectively suppressed even with the passage of time. Therefore, as a material that enables complex treatment combined with photothermal therapy and immunotherapy, the temperature-sensitive hydrogel of the present invention having the aforementioned effect can be usefully utilized in the field of medicine for cancer treatment.
Owner:KOREA NAT UNIV OF TRANSPORTATION IND ACADEMIC COOP FOUND

Preparation of an anti-inflammatory peptide hydrolyzed from shell nacre protein and its application in skin repair

The present invention discloses the preparation of an anti-inflammatory peptide derived from the hydrolysis of shell nacre protein and its application in skin repair. The peptide PDFDNGF provided by the invention can effectively promote the proliferation of RAW264.7 macrophage cells and inhibit the excessive production of nitric oxide and cytokines in RAW264.7 cells induced by lipopolysaccharide, while increasing the levels of anti-inflammatory cytokines, demonstrating significant anti-inflammatory activity. Furthermore, the active peptide has a significant proliferative effect on L929 cells, indicating its potential to promote skin wound healing. This invention provides a theoretical basis for the high-value utilization of shell nacre.
Owner:SOUTH CHINA AGRICULTURAL UNIVERSITY

Gas compressor gas pipe sealing detection device and detection process

The invention discloses a gas compressor gas pipe sealing detection device and detection process, and relates to the technical field of gas pipe detection, the detection device comprises a detection table, a detection box is fixedly arranged on the detection table, a first gas transmission module is arranged on the detection box, and the first gas transmission module is used for inputting oxygen into the detection box; a positioning module used for positioning the air pipe body is further arranged on one side of the detection box, a feeding port is formed in the side, close to the positioning module, of the detection box, and a feeding module is further arranged on the detection table and used for inputting the positioned air pipe body into the detection box; a second gas transmission module is further arranged in the detection box, and the second gas transmission module is used for inputting nitric oxide into the gas pipe body; by means of the detection method, the leakage point can be positioned, and in the detection process, detection liquid cannot be attached to the air pipe body, so that subsequent cleaning and drying treatment is not needed, the detection precision and efficiency are effectively improved, and batch production of the air pipe of the air compressor is facilitated.
Owner:SHAOSHAN CHANGJI MACHINERY TECHNOLOGY CO LTD

Hydrogen fuel nozzle and combustor with cavity trapped vortex enhanced mixing

The invention relates to the technical field of combustion equipment, and provides a hydrogen fuel nozzle with cavity trapped vortex reinforced mixing and a combustor, the hydrogen fuel nozzle with cavity trapped vortex reinforced mixing comprises a cartridge receiver, a flame tube, a first air inlet pipe and a plurality of micro-mixing spray pipes, and a gas collection cavity is formed in the end, close to an air inlet, of the flame tube; a plurality of mounting channels are formed in the end, close to the air inlet, of the flame tube and penetrate through the mounting cavity, the air collecting cavity and the spraying cavity; each micro-mixing spray pipe is mounted in one mounting channel and comprises a gas inlet end and a gas outlet end, the gas inlet end is communicated with the mounting cavity, the gas outlet end is communicated with the spraying cavity, a groove is formed in the inner wall of each micro-mixing spray pipe, and a vent hole communicated with the gas collecting cavity is formed in the bottom wall of each groove. When air flows in the micro-mixing spray pipe and passes through the groove, vortex is generated in the groove, in this way, mixing of the air and fuel gas is enhanced through the vortex, the mixing uniformity is effectively improved, and therefore emission of nitric oxide is reduced.
Owner:BEIHANG UNIV +1

Nitric-Oxide Ionization Induced Flow Tagged Imaging (NiiFTI)

Nitric-oxide ionization induced flow tagging and imaging (NiiFTI) is described. In one embodiment a method for characterizing a flow of a gas containing an agent includes ionizing the agent by a source of pulsed light emitting at a frequency overlapping a resonant transition frequency of the agent. In response to ionizing of the agent, a fluorescence of the gas is generated. The method also includes capturing at least one time-delayed image of the flow of the gas, where the capturing is time-delayed with respect to a pulse of the source of pulsed light. The method includes determining at least one property of the flow of the gas by analyzing the at least one time-delayed image of the flow.
Owner:TEXAS A&M UNIVERSITY

Medical device for evaluating physiological parameters of respiratory system

The invention relates to a medical device for evaluating physiological parameters of a respiratory system, and the device comprises a sampling device which is used for collecting detected exhaled gas after a rising inflection point of carbon dioxide; the gas sensor comprises a nitric oxide sensor and a carbon dioxide sensor; the processor is used for receiving the gas signal generated by the gas sensor; the processor is configured to establish a linear expression for calculating a risk parameter R according to the detected carbon dioxide concentration and nitric oxide concentration; the linear expression of the risk parameter R is shown in the specification; wherein the parameter is set as a constant; the parameter is nitric oxide concentration; the parameter is carbon dioxide concentration; and the parameter is a nitric oxide dynamic change rate function. Compared with the prior art, the method provided by the invention provides a more comprehensive evaluation capability for airway inflammation and abnormal ventilation.
Owner:SUZHOU CHUANGLAI ELECTRONIC TECH CO LTD

Chemical plant discharge filtering device with monitoring function

The invention relates to the technical field of chemical plant smoke filtering, in particular to a chemical plant discharge filtering device with a monitoring function, which comprises a barrel, a gas inlet pipe, a gas outlet pipe and the like, the barrel is communicated with the gas inlet pipe, and the top of the barrel is communicated with the gas outlet pipe. Indexes of pollutants such as sulfur dioxide, nitric oxide, carbon monoxide and carbon dioxide in flue gas can be detected through the flue gas sensor, when the flue gas sensor detects that the pollutants in the flue gas exceed the standard, the controller can control an electric guide rail to work, the electric guide rail drives a first push plate to move forwards, and a first sealing plate can also move forwards; the first sealing plate seals the exhaust pipe, real-time response can be achieved after the filter element is aged and breaks down, the filter element is replaced without shutdown under the condition that it is ensured that smoke does not leak, smoke which is not completely purified is prevented from being exhausted out, and therefore pollution to the environment can be avoided.
Owner:GANNAN UNIV OF SCI & TECH

Ammonia-doped hydrogen-doped low-nitrogen coal-fired boiler and working method thereof

The invention belongs to the technical field of low-nitrogen combustors, and discloses an ammonia-doped hydrogen-doped low-nitrogen coal-fired boiler and a working method thereof.Each corner of a corner tangential boiler body is provided with a plurality of primary air nozzles in the height direction of a main combustion area, the primary air nozzles are provided with stable combustion teeth, and the stable combustion teeth are used for transversely dividing primary air into a thick part and a thin part; a concentrated phase is arranged inside, and a light phase is arranged outside; an ammonia-doped and hydrogen-doped nozzle is arranged above and / or below each primary air nozzle; and each corner of the four-corner tangential boiler body is provided with an over-fire air nozzle in the over-fire air area. By controlling supply of air, fire coal, ammonia and hydrogen fuel, the combustion process is carried out in stages, and generation of nitric oxide is effectively reduced.
Owner:XIAN TPRI BOILER ENVIRONMENTAL PROTECTION ENG CO LTD +1

Methods of treating central nervous system disorders comprising administering lumateperone and a nitric oxide donor

ActiveUS12478623B2Organic active ingredientsOrganic chemistryLumateperoneNeurological problems
The disclosure provides methods for the for treatment of psychosis, such as schizophrenia, or depression (such as bipolar depression) and / or anxiety, comprising administering to a patient in need thereof, (i) a 5-HT2A or 5-HT2A / D2 receptor ligand, for example a substituted heterocycle fused gamma-carboline as described herein, in free, pharmaceutically acceptable salt or prodrug form, and (ii) a nitric oxide donor, separately (sequentially or simultaneously), or in combination (e.g., in a fixed dose combination).
Owner:INTRA CELLULAR THERAPIES INC

Method for preparing short-chain diacid by catalytically oxidizing polyethylene with ionic liquid

The invention relates to the technical field of chemical synthesis, and discloses a method for preparing short-chain diacid by catalytic oxidation of polyethylene with an ionic liquid, which comprises the following steps: mixing the ionic liquid and polyethylene, and mixing for oxidation reaction in the presence of nitric oxide and oxygen to obtain the short-chain diacid. According to the method, the polyethylene is adopted as the raw material for the first time, the ionic liquid is used as the reaction catalyst and the reaction medium, nitric oxide is catalyzed to generate nitrogen dioxide, efficient catalytic oxidation of the polyethylene is achieved, the short-chain diacid product with the carbon number of 4-12 is obtained, the highest yield reaches 90% or above, and the influence on the yield is not large when the polyethylene recycled material is adopted. The method not only solves the problem of polyethylene waste recovery, but also solves the problem of high preparation cost of short-chain diacid, so that the preparation cost is greatly reduced.
Owner:ZHEJIANG UNIV +1

Nitric oxide inhalation therapy for infants with bronchiolitis

The invention provides a method of delivering, by intermittent inhalation, 200 ppm to 320 ppm gNO for 10 to 45 minutes 2 to 5 times per day to provide a therapeutic amount of gaseous nitric oxide (gNO) wherein the therapeutic amount is a nitric oxide-load (NO load) of 300 ppm-hrs to 900 ppm-hrs of gNO per day over a period of at least 14 days to a patient in need thereof, wherein the patient has a condition associated with a pathogenic microorganism, wherein the intermittent inhalation comprises inhalation of the gNO for a first time period, followed by inhalation of a gas essentially devoid of gNO for a second time period.
Owner:BEYOND AIR LTD

Method for removing NOX in flue gas by utilizing desulfurization tail liquid of molten lead-zinc slag after iron extraction and dilution in cooperation with oxidizing agent

The invention relates to the technical field of industrial flue gas purification, in particular to a method for removing NOX in flue gas through cooperation of iron-extracted and depleted molten lead-zinc slag desulfurization tail liquid and an oxidizing agent, and the method comprises the following steps that S1, iron-extracted and depleted molten lead-zinc slag is ground till the particle size is not larger than 0.075 mm, water is added according to the solid-to-liquid ratio of 1: 200 g / mL, and ore pulp is prepared; s2, flue gas containing SO2 is introduced into the ore pulp, and SO2 in the flue gas is removed; s3, raising the temperature of the desulfurization tail liquid from which SO2 is removed to 25-65 DEG C, adding an oxidizing agent, introducing NOX-containing flue gas, and removing NOX in the flue gas; according to the method, the nitric oxide can be effectively removed by utilizing the desulfurization tail liquid of the molten lead-zinc slag after iron extraction and dilution, so that the comprehensive utilization of resources is realized.
Owner:KUNMING UNIV OF SCI & TECH

Double-network structure artificial blood vessel with anticoagulation, endothelium promotion and anti-infection functions and preparation method of double-network structure artificial blood vessel

The invention relates to the technical field of biomedical materials, in particular to a double-network structure artificial blood vessel with anticoagulation, endothelium promotion and anti-infection functions and a preparation method of the double-network structure artificial blood vessel. The artificial blood vessel comprises a polymer fiber network artificial blood vessel substrate, a microscopic network hydrogel layer penetrating through the polymer fiber network artificial blood vessel substrate, and magnesium-copper alloy particles doped in the hydrogel layer. According to the artificial blood vessel with the double-network structure, the problem that a traditional small-caliber artificial blood vessel is insufficient in mechanical performance is greatly solved, copper ions and magnesium ions are released to the surrounding environment by means of degradation of the magnesium-copper alloy particles in the using process, the microenvironment of the surrounding tissue is adjusted to be alkalescent, nitric oxide is catalytically released, and the mechanical performance of the artificial blood vessel is improved. The artificial blood vessel with the double-network structure is endowed with anticoagulation, endothelium promotion and anti-infection functions. The problems of restenosis and insufficient endothelialization of a small-caliber artificial blood vessel in the prior art are comprehensively solved, and the long-term patency rate of the artificial blood vessel is increased.
Owner:INST OF METAL RESEARCH - CHINESE ACAD OF SCI

Fluorescent probe as well as preparation method and application thereof

The invention discloses a fluorescent probe as well as a preparation method and application thereof. The invention provides a series of fluorescent probes with novel structures, and the fluorescent probes take 2-(isoquinoline-1-yl) pyrrole boron difluoride as fluorophores, so that the fluorescence quantum yield of the probes is improved, the detection resolution of nitric oxide is increased, and the detection sensitivity is improved. The fluorescent probe disclosed by the invention has the characteristics of large Stokes displacement, high fluorescence quantum yield, good selectivity and short response time.
Owner:WUYI UNIV

Giant salamander immunoregulation meat peptide and application thereof

The invention discloses a giant salamander immune regulation meat peptide and application thereof. The meat peptide comprises one or more than two polypeptides selected from SEQ ID NOs: 1-5. The polypeptide can enhance cellular immune response, such as enhancing macrophage proliferation activity, improving macrophage nitric oxide secretion level, enhancing macrophage phagocytic ability, enhancing macrophage antigen presentation ability, enhancing immune organ functions, regulating T cell subpopulation, improving cellular immune factor level and enhancing immune globulin level.
Owner:TSINGHUA SHENZHEN INTERNATIONAL GRADUATE SCHOOL

Application of immature bitter orange extract in preparation of antioxidant and anti-inflammatory drugs

The invention provides application of an immature bitter orange extract in preparation of anti-oxidation and anti-inflammatory drugs. The fructus aurantii immaturus is extracted by using different solvents, and the extract is researched, so that the fructus aurantii immaturus extract has the capability of removing superoxide anion free radicals, ABTS free radicals and DPPH free radicals; in addition, the immature bitter orange extract can also reduce the content of nitric oxide, tumor necrosis factor-alpha, interleukin-1beta and interleukin-6 released by LPS-induced macrophages. The fructus aurantii immaturus extract has anti-oxidation and anti-inflammatory effects, and is used as an anti-oxidation and anti-inflammatory drug to develop a new application of an old drug of the fructus aurantii immaturus extract.
Owner:BEIJING INSTITUTE OF PETROCHEMICAL TECHNOLOGY

Composition for preventing and treating eggplant root rot

The invention discloses a composition for preventing and treating eggplant root rot, and relates to the technical field of biological prevention and treatment. The composition consists of three parts, namely a double-stranded RNA (Ribonucleic Acid) delivery body controlled by a kaolinite nanotube-metal polyphenol network-boric acid ester, a nitric oxide / hydrogen sulfide double-pulse microcapsule and volatile organic compound particles of beta-cyclodextrin cross-linked aerogel, wherein the three parts are matched according to the total mass ratio of 1: (0.8-1.5): (0.8-1.2). Through structural design, time sequence release of non-overlapping peak values is realized, and a prevention and control mode for inhibiting environment enhancement host precise silencing is formed. The deliverer can be selectively disintegrated under the condition of pathogen-induced organic acid, iron chelating agent and hydrogen peroxide, so that the targeted release of the double-stranded RNA is realized; the double-pulse microcapsule respectively releases nitric oxide and hydrogen sulfide in a transplanting stress stage and an early disease stage, and induces host defensive gene expression; the aerogel particles continuously release 2, 3-butanediol and aromatic aldehyde to inhibit germination of pathogenic bacteria and serve as rhizosphere signals to enhance host resistance.
Owner:HONGHE PINGBIAN TIANSHI AGRI TECH DEV CO LTD

Preparation method and application of targeted nanoparticles for delivering gas and small molecule drugs based on ultrasonic piezoelectric catalysis

The invention belongs to the field of biological medicine and ultrasonic medicine, and provides a barium titanate (BTO) piezoelectric material-based ultrasonic responsive targeting nano system (BTO at BAL), which is used for matrix microenvironment remodeling and immunopotentiation of compact tumors such as pancreatic cancer and the like. According to the nanoparticles, oleic acid modified BTO is taken as a core, ROS responsive prodrug molecules containing a small molecule PD-L1 inhibitor BMS1166 and a nitric oxide donor (Arg) 9 are loaded on the surface, and specific targeting on pancreatic cancer cells is realized by combining a targeting peptide LFC131. Under ultrasonic excitation, BTO generates reactive oxygen species (ROS), on one hand, (Arg) 9 is oxidized to release NO, tumor matrix is degraded, tumor hardness is reduced, drug delivery efficiency is improved, and meanwhile, ROS and NO synergistically enhance tumor immunogenicity; on the other hand, the ROS breaks a thioketal bond to release BMS1166, PD-L1 expression is down-regulated, and immunosuppression is reversed. According to the present invention, the significant tumor inhibition and immune activation effects are represented in the animal model, and the clinical transformation potential is provided.
Owner:PEKING UNIVERSITY THIRD HOSPITAL (THE THIRD CLINICAL MEDICAL SCHOOL OF PEKING UNIVERSITY)

Highly portable gas delivery systems

Provided are devices for engaging highly portable gas containers are provided that include a mouthpiece component comprising a flexible mouthguard, a variable inlet component that allows gas to flow from two or more sources to the user, or both. In embodiments such a device comprises engagement means for engaging gas container(s), a transition element that comprises an interior flow passage and a substantially rigid or resilient body, and optionally, a lip engagement component. The devices can be used in assemblies / devices that comprise one or more gas containers containing gas, e.g., an oxygen-rich gas and possibly other ingredients, such as nitric oxide, helium, or active pharmaceutical ingredients. In aspects, the components engage a gas container operable as a gas delivery system independently of such components. Also provided are methods of using such devices, e.g., in delivering oxygen to a person exposed to undesirable saliva-transmissible agents, e.g., harmful chemicals or infectious agents.
Owner:MINOGUE MICHAEL

Intelligent quintuplet cooperative plasma self-purification robot long-term storage system and self-adaptive disinfection control method

PendingCN121550458ASeed preservation using chemicalsSeed preservation by irradiation/electric treatmentCold chainChlorine dioxide
The invention discloses an intelligent quintuplet cooperative plasma self-purification robot long-term storage system and a self-adaptive disinfection control method. According to the system, cold plasma, ozone, chlorine dioxide, self-generated nitric oxide and a charge self-purification jump effect are fused, and a dynamic self-purification system with an electric field-gas field-chemical field-intelligent field-thermal field five-dimensional synergistic energy field is constructed. The robot adopts a three-section structural layout and a multi-mode self-adaptive propulsion mechanism, environmental parameters are sensed through AI, discharge power and oxidant release are intelligently regulated and controlled, and precise sterilization, toxicity reduction and mildew prevention in a multi-medium environment are achieved. The system can generate various high-energy active species containing. OH, O, NO, ClO, ONOO and the like, chain splitting decomposition and oxidation mineralization are carried out on mold spores, bacterial cells, aflatoxin and the like, the sterilization rate reaches 99.995%, and the toxin degradation rate exceeds 98%. The system has the characteristics of no residue, low energy consumption, long-acting self-maintenance and the like, is suitable for multiple scenes of grain storage, traditional Chinese medicinal materials, cold chains, farmland, public health and the like, and realizes an intelligent, continuous and chemical-additive-free green storage and dynamic purification system.
Owner:沈哲明

Inhalation of nitric oxide for treating respiratory diseases

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract. The disclosed method can be effected while monitoring one or more of on-site and off-site parameters such as vital signs, methemoglobin levels, pulmonary function parameters, blood chemistry and hematological parameters, blood coagulation parameters, inflammatory marker levels, liver and kidney function parameters and vascular endothelial activation parameters, such that no substantial deviation from a baseline in seen in one or more of the monitored parameters.
Owner:BEYOND AIR LTD

Tail gas treatment device for sodium nitrate production equipment by neutralization method

The utility model provides a tail gas treatment device for sodium nitrate production equipment by a neutralization method, which comprises a tail gas air pipe (20), an induced draft fan (2) and an exhaust funnel (6), a primary absorption tower (3) and a secondary absorption tower (4) which are connected in series with a reaction kettle (1) are communicated by the tail gas air pipe (20), an upper air outlet of the secondary absorption tower (4) is connected with the exhaust funnel (6), and the upper side of the exhaust funnel (6) is communicated with the atmosphere. And a sodium bicarbonate solution is sprayed in the first-stage absorption tower (3) and the second-stage absorption tower (4). The induced draft fan (2) is used for generating negative pressure in the reaction kettle (1), tail gas is sucked out, and the tail gas can be prevented from leaking from the sampling opening (11) and the simple manhole (12). The first-stage absorption tower (3) and the second-stage absorption tower (4) are used for spraying sodium bicarbonate to neutralize tail gas generated in the neutralization reaction, the treated tail gas does not contain nitric oxide any more, the treatment process is simple, consumed materials are few, and the cost is low.
Owner:QINGHAI SALT LAKE IND

Energy-saving efficient low-nitrogen combustion device for boiler manufacturing

The invention belongs to the technical field of low-nitrogen combustion, and particularly relates to an energy-saving efficient low-nitrogen combustion device for boiler manufacturing, which comprises a bottom plate, a support frame fixedly mounted on the bottom plate, a controller fixedly mounted on the support frame, a guide assembly arranged on the support frame, an adjusting assembly arranged on the support frame, and a bottom frame fixedly mounted on the bottom plate, a calibration assembly is arranged on the bottom frame, a combustion chamber is arranged in the bottom frame, a top cover is arranged at the top of the combustion chamber, a driving motor is fixedly installed on the top cover, and a stirring rod is rotationally arranged on the top cover. According to the energy-saving high-efficiency low-nitrogen combustion device for boiler manufacturing, when fuel and air are stirred and mixed, impurities can be effectively prevented from being adsorbed on the inner wall of the combustion chamber, the plate strips can scrape and clean the impurities adsorbed on the inner wall of the combustion chamber, the impurities are prevented from being adsorbed on the combustion chamber, and the fuel and the air are conveniently mixed; and therefore, the fuel and the air can be effectively and uniformly mixed, a local high-temperature area is avoided, and generation of nitric oxide is reduced.
Owner:LINYI SHUANGDING THERMAL POWER CO LTD