184 results about "Nitric oxide" patented technology

The invention relates to the technical field of biomedical materials, in particular to a double-network structure artificial blood vessel with anticoagulation, endothelium promotion and anti-infection functions and a preparation method of the double-network structure artificial blood vessel. The artificial blood vessel comprises a polymer fiber network artificial blood vessel substrate, a microscopic network hydrogel layer penetrating through the polymer fiber network artificial blood vessel substrate, and magnesium-copper alloy particles doped in the hydrogel layer. According to the artificial blood vessel with the double-network structure, the problem that a traditional small-caliber artificial blood vessel is insufficient in mechanical performance is greatly solved, copper ions and magnesium ions are released to the surrounding environment by means of degradation of the magnesium-copper alloy particles in the using process, the microenvironment of the surrounding tissue is adjusted to be alkalescent, nitric oxide is catalytically released, and the mechanical performance of the artificial blood vessel is improved. The artificial blood vessel with the double-network structure is endowed with anticoagulation, endothelium promotion and anti-infection functions. The problems of restenosis and insufficient endothelialization of a small-caliber artificial blood vessel in the prior art are comprehensively solved, and the long-term patency rate of the artificial blood vessel is increased.

The invention discloses a composition for preventing and treating eggplant root rot, and relates to the technical field of biological prevention and treatment. The composition consists of three parts, namely a double-stranded RNA (Ribonucleic Acid) delivery body controlled by a kaolinite nanotube-metal polyphenol network-boric acid ester, a nitric oxide / hydrogen sulfide double-pulse microcapsule and volatile organic compound particles of beta-cyclodextrin cross-linked aerogel, wherein the three parts are matched according to the total mass ratio of 1: (0.8-1.5): (0.8-1.2). Through structural design, time sequence release of non-overlapping peak values is realized, and a prevention and control mode for inhibiting environment enhancement host precise silencing is formed. The deliverer can be selectively disintegrated under the condition of pathogen-induced organic acid, iron chelating agent and hydrogen peroxide, so that the targeted release of the double-stranded RNA is realized; the double-pulse microcapsule respectively releases nitric oxide and hydrogen sulfide in a transplanting stress stage and an early disease stage, and induces host defensive gene expression; the aerogel particles continuously release 2, 3-butanediol and aromatic aldehyde to inhibit germination of pathogenic bacteria and serve as rhizosphere signals to enhance host resistance.

The invention discloses an intelligent quintuplet cooperative plasma self-purification robot long-term storage system and a self-adaptive disinfection control method. According to the system, cold plasma, ozone, chlorine dioxide, self-generated nitric oxide and a charge self-purification jump effect are fused, and a dynamic self-purification system with an electric field-gas field-chemical field-intelligent field-thermal field five-dimensional synergistic energy field is constructed. The robot adopts a three-section structural layout and a multi-mode self-adaptive propulsion mechanism, environmental parameters are sensed through AI, discharge power and oxidant release are intelligently regulated and controlled, and precise sterilization, toxicity reduction and mildew prevention in a multi-medium environment are achieved. The system can generate various high-energy active species containing. OH, O, NO, ClO, ONOO and the like, chain splitting decomposition and oxidation mineralization are carried out on mold spores, bacterial cells, aflatoxin and the like, the sterilization rate reaches 99.995%, and the toxin degradation rate exceeds 98%. The system has the characteristics of no residue, low energy consumption, long-acting self-maintenance and the like, is suitable for multiple scenes of grain storage, traditional Chinese medicinal materials, cold chains, farmland, public health and the like, and realizes an intelligent, continuous and chemical-additive-free green storage and dynamic purification system.

The utility model discloses a diesel generator flue gas purification mechanism for civil air defence engineering, including air inlet pipe and purification bin, the air inlet pipe one end is linked with diesel generator exhaust pipe in civil air defence engineering power generation room intercommunication, the other end of air inlet pipe is inserted into the purification bin and the opening direction is perpendicular to downward, the open end position of air inlet pipe in the purification bin is connected with the shunt joint, each interface of shunt joint all is connected with the jet pipe that the air hole of pipe body lateral wall is evenly set up, the utility model relates to civil air defence engineering technical field, utilize liquid supply booster pump and press into the spray subassembly in alkaline solution (15% magnesium hydroxide compound agent), and further via spray subassembly to the spray of filler layer, make the nitrogen monoxide, nitrogen dioxide, sulfur dioxide and particulate matter etc. in tail gas contact with the alkaline water mist in purification bin and filler layer, to the purification treatment of nitrogen monoxide, nitrogen dioxide, sulfur dioxide and particulate matter.

This invention provides a gas-phase molecular absorption spectrometry-naphthylethylenediamine hydrochloride spectrophotometric method for determining total nitrogen in waste gas from stationary pollution sources. The method comprises the following steps: S1. Reacting the waste gas with an oxidant; S2. Using an absorbent, further reacting the waste gas after S1; S3. Collecting the oxidant after S1, pretreating it to reduce nitrogen-containing compounds to nitric oxide, and detecting the total nitrogen content I; S4. Collecting the absorbent after S2 to obtain the total nitrogen content II; S5. Summing the total nitrogen content I and total nitrogen content II to obtain the total nitrogen content in the current waste gas. This method enables accurate determination of total nitrogen in waste gas from stationary pollution sources.

The invention relates to hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel, and belongs to the technical field of hydrogel dressings. The invention discloses an exosome hydrogel, which is characterized in that exosome is loaded in crosslinked aldehyde hyaluronic acid and carboxymethyl chitosan, the aldehyde hyaluronic acid is grafted with L-arginine, and the exosome is derived from bone marrow mesenchymal stem cells. L-arginine can release nitric oxide under the action of a diabetic wound surface or an inflammation microenvironment to achieve the effects of resisting bacteria and promoting wound surface recovery, and the exosome successfully avoids the risks of cell survival defects, vascular embolism, immunological rejection and the like while retaining powerful bioactive components. The product has excellent antibacterial activity, degradability, tissue adhesion, injectable performance and self-repairing performance, and can be suitable for wounds in different shapes.

The invention discloses a construction method of a coronary artery microcirculation disturbance cell model, and belongs to the technical field of biological medicine. According to the method, mouse heart microvascular endothelial cells (MCMEC) are taken as objects, tetrachlorohydroquinone (TCHQ) is used for treating for 6 hours at the concentration of 20-40 [mu] M, and CMD typical characteristics such as apoptosis, increase of reactive oxygen species (ROS), reduction of nitric oxide (NO) and release of inflammatory factors (TNF-alpha and IL-1beta) of the cells are induced. The TCHQ is applied to construction of the CMD model for the first time, and the model is stable, good in repeatability and capable of being used for CMD pathogenesis research and drug screening.

This disclosure provides a system and method for non-invasively delivering ultrasound (US) pulses to a target site in a subject. The target site is either a blood vessel or blood-flowing tissue. By delivering US pulses to the target site, a therapeutic process in the body is facilitated. This therapeutic process is typically associated with the production of nitric oxide molecules induced by ultrasound irradiation. This disclosure provides a solution combining a US transducer with one or more sensors. The sensors can detect parameters indicating whether the US transducer is properly coupled and positioned to the subject's body site, enabling safe application of US pulses, or whether the subject and / or target area are in a state to tolerate ultrasound irradiation.

The invention discloses a dual-channel fluorescent probe for simultaneously detecting nitric oxide and cysteine as well as a preparation method and application of the dual-channel fluorescent probe. The structural formula of the dual-channel fluorescent probe is shown in the specification. The invention also specifically discloses a preparation method of the dual-channel fluorescent probe and application of the dual-channel fluorescent probe in selective detection of NO and Cys, dynamic visual detection of NO and Cys in a biological cell system and in ferroptosis and depression cell models. The dual-channel fluorescent probe disclosed by the invention has the advantages of strong specificity, good selectivity, no spectrum crosstalk and the like.

The invention discloses flammulina velutipes polysaccharide nano-liposome as well as a preparation method and application thereof, and belongs to the technical field of biological functional materials. The preparation method specifically comprises the following steps: (1) sequentially performing hot water extraction, deproteinization, alcohol precipitation, dialysis and freeze-drying on flammulina velutipes raw material powder; (2) dissolving in a phosphoric acid buffer solution; (3) mixing and dissolving phospholipid, cationic lipid and a membrane regulator in an organic solvent; (4) mixing and ultrasonic treatment; and (5) carrying out reduced-pressure rotary evaporation, hydration with a phosphate buffer solution, ultrasonic treatment and extrusion. According to the flammulina velutipes polysaccharide nano-liposome and the preparation method thereof, cholesterol is replaced by phytosterol ester to prepare the flammulina velutipes polysaccharide nano-liposome, flammulina velutipes polysaccharide (FVP) is encapsulated in a water core in the liposome, the safety is higher, and the encapsulation efficiency, the storage stability and the immunocompetence of a system are improved. In-vitro experiments prove that the phytosterol ester lipidosome has the effect of promoting macrophage proliferation and nitric oxide generation, and the effect is obviously better than that of the traditional cholesterol lipidosome under the same condition.

The utility model discloses a nitric acid production unit and device, and relates to the technical field of nitric acid production equipment. The nitric acid production unit comprises an air compressor, a nitric oxide compressor, an expansion machine and a driving module, the driving module comprises a driving machine and two first-stage transmission shafts, and the two first-stage transmission shafts are connected with the driving machine; wherein one first-stage transmission shaft is connected with one of the air compressor, the nitrogen oxide compressor and the expansion machine, and the other first-stage transmission shaft is correspondingly connected with the rest one or two of the air compressor, the nitrogen oxide compressor and the expansion machine. According to the nitric acid production unit, the axial length of the nitric acid production unit is shortened, the use number of couplings is reduced, the torsional vibration problem is greatly reduced, and the stability and reliability of the whole nitric acid production unit are greatly improved.

The invention belongs to the technical field of medicines, and particularly relates to a phenanthroindolizidine alkaloid compound and application thereof. The invention discloses two kinds of phenanthroindolizidine alkaloid compounds, namely (-)-(R)-13a alpha-secoxanthin and (-)-(R)-13a alpha-6-O-desmylanthin, which are derived from a traditional Chinese medicine cynanchum atratum, and discloses the obvious anti-neuritis activity of the phenanthroindolizidine alkaloid compounds for inhibiting the generation of nitric oxide. Animal experiments prove that by intraperitoneal injection of the (-)-(R)-13a alpha-secoxanthin and the (-)-13a alpha-6-O-desmylanthin, the autonomous movement ability of a depression mouse is remarkably improved, the exploration behavior of the mouse is recovered, the anxiety symptom of the mouse is relieved, and the despair behavior of the mouse is relieved. The invention provides a new lead compound for research and development of new antidepressant drugs.

The invention discloses a pulverized coal combustion method and system suitable for low-load operation of a boiler, and the method comprises the steps that high-temperature flames are provided through an independent fire source, so that the high-temperature flames and air distribution of an original combustor form a fire-rich and thin air cascade combustion mode, and the high-temperature flames supplement insufficient fire heat; by controlling the mixing proportion of high-temperature flames and air powder, the hearth temperature and the oxygen concentration are adjusted, so that low-load stable combustion is achieved, and generation of nitric oxide is restrained; by additionally arranging the independent fire source, the insufficient ignition heat is supplemented, and the problems that the boiler is low in hearth temperature, weak in airflow and unstable in combustion during low-load operation are solved. The independent fire source and the original primary air pulverized coal are simultaneously fed into the boiler for continuous combustion. High-temperature flames and air distribution of an original combustor form a fire-rich and thin air cascade combustion mode, and it can be guaranteed that the unit is stably ignited and combusted under any load.

The application discloses a pterosin sesquiterpenoid compound and a preparation method and application thereof, belongs to the technical field of biological medicines, aims at the problems of a research blank of pterosin sesquiterpenoid compounds in Anemone raddeana and a lack of structure-confirmed anti-inflammatory active monomers, and provides a pterosin sesquiterpenoid compound with a structural formula as shown in the following.The compound preparation needs to first crush dried whole grass of Anemone raddeana, extract by heating and refluxing with an organic solution, concentrate under reduced pressure to obtain total extract; then, the extract is extracted by petroleum ether, ethyl acetate and n-butanol step by step, the ethyl acetate part extract is enriched, and the high-purity product is prepared through multi-step purification of a silica gel column, a C-18 reverse phase column, a gel column and semi-preparative liquid chromatography.In addition, the compound can dose-dependently inhibit the NO release of LPS-induced macrophages, and can be used for preparing anti-inflammatory drugs for treating or preventing inflammatory diseases related to excessive production of nitric oxide, fills the research blank, and provides a high-quality candidate component for anti-inflammatory drug research and development.

An example of a nitric oxide (NO) generating system includes an NO generating formulation, having: a stable NO donor / adduct; a hydrophilic binder; and an additive. The additive is to control a rate of release of NO from the stable NO donor / adduct after the formulation is exposed to an effective amount of water, water vapor, or blue or ultraviolet (UV) light. This example NO generating system further includes an inhalation device in operative contact with the NO generating formulation.

The invention relates to a Pd / F-Al2O3 catalyst with strong metal-carrier interaction and a preparation method and application thereof in the technical field of selective catalytic reduction, a catalytic material comprises an active component and a carrier material, the active component is Pd, the carrier material is F-Al2O3 rich in F center and AlV center, and the mass fraction of the active component is 0.5 wt.%. A carrier F-Al2O3 is prepared through high-temperature treatment of basic aluminum acetate in an argon atmosphere, Pd active components are loaded on the surface of the carrier by adopting an initial wet impregnation method, and the efficient catalytic material for nitrous oxide-ammonia gas selective catalytic reduction reaction is finally prepared after centrifugation, drying and calcination in an air atmosphere. The prepared catalytic material has the advantages of being high in metal-carrier interaction, good in active component dispersity and simple in preparation process, the T90 temperature required by the catalytic efficiency reaching 90% is reduced by 30% compared with that of a traditional Pd / Al2O3 catalyst, the wide industrial application prospect is achieved, and upgrading and optimization of the nitrogen oxide pollution control technology are promoted.

This application relates to the field of biomedical materials and discloses a bio-based functional material that promotes blood circulation and its preparation method. The material is in hydrogel form and is prepared from an active precursor solution, a hydrogel matrix solution, and a functional modifier. The active precursor solution is assembled using a eutectic solvent-mediated process, which breaks the hydrogen bonds within the lignin molecule, causing its conformation to unfold, and constructs coordination catalytic centers with copper and chloride ions. The hydrogel matrix solution is mainly composed of polyvinyl alcohol and water. The preparation method includes high-temperature pre-assembly of the precursor, two-phase mixing, reduction regulation, and freeze-thaw cycle molding. This invention utilizes the microenvironmental regulation effect of the eutectic solvent to lower the electron transfer barrier of copper ions and achieves stable anchoring of copper ions using the lignin framework, solving the problems of easy loss and deactivation of copper catalysts. It features high catalytic efficiency, good stability, and suitable mechanical strength, and can efficiently catalyze the release of nitric oxide from endogenous donors.

The invention provides a rehmannia pigment compound as shown in a formula (I), a stereoisomer thereof or pharmaceutically acceptable salt thereof, and particularly relates to the technical field of natural pharmaceutical chemistry and pharmaceutical compounds. The invention aims to solve the problems that the radix rehmanniae pigment is not clear in material basis and lacks a compound with a clear structure and excellent anti-inflammatory activity. The rehmannia pigment compound disclosed by the invention comprises a structure as shown in a formula (I). The invention also discloses a preparation method of the compound and application of the compound in medicines. The compound has a novel chemical structure and remarkable anti-inflammatory activity, release of nitric oxide can be effectively inhibited in a lipopolysaccharide induced macrophage model, the cytotoxicity is far lower than that of a positive control drug quercetin, and the compound shows huge potential as an anti-inflammatory drug lead compound.

This invention belongs to the field of biomedical materials and nanotechnology, specifically relating to the synthesis and application of a multifunctional mesoporous nanomaterial. The inventors synthesized a core-shell structured mesoporous nanoparticle using mesoporous silica nanoparticles and dopamine via emulsion epitaxy. The core of the core-shell structured mesoporous nanoparticle is S-nitrosoglutathione supported on mesoporous silica, and the outer shell is pentafluorophenyl chlorophyll supported on mesoporous polydopamine, forming MSN / G@mPDA / F nanoparticles. These nanoparticles rapidly increase in temperature to 45°C under 808 nm laser irradiation. o At temperatures above a certain temperature, S-nitrosoglutathione decomposes to produce nitric oxide. Further irradiation at 750 nm generates a large amount of reactive oxygen species, killing bacteria. This combination of photothermal and photodynamic therapy effectively inhibits bacterial growth. Therefore, this method exhibits excellent antibacterial effects and can play a role in the future treatment of bacterial infections.

The invention relates to a composition and method to increase survival of fish following catch-and-release events. The composition comprises an energy substrate and a hydrocolloid. The composition may comprise an application-safe buffer. The energy substrate may be a glycolysis metabolite, a Krebs cycle metabolite, an amino acid, a nitric oxide donor, a triglyceride, and mixtures thereof. The hydrocolloid may be a polysaccharide. The composition may include an oxygenated substrate, a trophic hormone, a stress reducing additive, a chelating agent, an antimicrobial preservative, and a color additive, and mixtures thereof. The method comprises after catching the fish, applying the composition to the fish and releasing the fish back into the wild. The composition may alternatively be mixed with a flotant or a cured polymer in the shape of a lure such that composition may be dispersed onto the oxygen exchange tissue of the fish when it is caught.

The invention relates to an engine control method and device, a storage medium, electronic equipment and a vehicle, and the method comprises the steps that in response to the situation that the vehicle is in a preset high-speed working condition, actual urea consumption and theoretical urea consumption within a preset unit distance are determined; and in response to the fact that the actual urea consumption is larger than the theoretical urea consumption, the operation mode of the engine is switched into a low-nitrogen-oxygen mode, and the low-nitrogen-oxygen mode is used for indicating the engine of the vehicle to operate according to a preset adjustment scheme so as to reduce generation of nitric oxide. When the vehicle is in the preset high-speed working condition, the actual urea consumption and the theoretical urea consumption within the preset unit distance can be calculated, and when the actual urea consumption is larger than the theoretical urea consumption, the operation mode of the engine is controlled to be switched into the low-nitrogen-oxygen mode, that is, operation is conducted according to the preset adjustment scheme, generation of nitric oxide is reduced, and the service life of the engine is prolonged. Therefore, emission limitation is met, and meanwhile excessive urea solution is prevented from being jetted.

This application relates to the field of gene transduction technology, specifically disclosing a method and application for modifying mesenchymal stem cells (MSCs) targeting myocardial injury. The method includes: S1, obtaining umbilical cord-derived MSCs; S2, performing surface biomimetic modification on the MSCs; S3, gene editing on the MSCs; and S4, co-incubating the engineered MSCs with enzyme-responsive liposomes loaded with nitric oxide donors. The liposomes are embedded in a gelatin coating on the cell membrane surface through hydrophobic interactions, forming a targeted therapeutic system. This method for modifying MSCs targeting myocardial injury can be used for regenerative therapy and repair of myocardial injury diseases such as myocardial infarction and ischemic heart disease. It comprehensively improves the survival and stress tolerance of cells after implantation and enhances the targeting precision to the damaged site, thereby achieving the advantages of efficient, precise, and highly adaptable myocardial repair.

Provided herein are method of treating a patient with nontuberculous mycobacteria by administering nitric oxide to the patient for at least 100 days to increase functional capacity and quality of life of the patient.

The present invention relates to a pharmaceutical composition. The pharmaceutical composition comprises cobra cardiotoxin (CDX) and a pharmaceutically acceptable carrier thereof. The pharmaceutical composition is further characterized by comprising use of cobra cardiotoxin (CDX) in combination with any one or both of the following drugs for treating migraine: cobra phospholipase A2 (PLA2) and cobra neurotoxin (NTX). The pharmaceutical composition can be used for preventing and treating migraine and down-regulating the concentration of nitric oxide (NO) in migraine patients. The pharmaceutical composition is of great significance for the treatment of migraine.

The utility model discloses a desulfurization and denitrification tail gas treatment device, which relates to the technical field of environmental protection and comprises a control system, a pretreatment unit, a nano-catalyst desulfurization unit, a low-temperature plasma denitrification unit, a byproduct collection and resourceful treatment unit and a tail gas emission unit, the activity is improved and the service life is prolonged through the nano catalyst, and the replacement frequency is reduced; nitric oxide is efficiently removed at a relatively low temperature through low-temperature plasma; real-time monitoring and intelligent adjustment are achieved through a PLC, a sensor and remote monitoring, and the system stability is improved; solid by-products are converted into fertilizers or building materials through the by-product treatment unit, so that resource utilization is realized, and environmental pollution is reduced; the device can be used for effectively removing sulfur dioxide and nitrogen oxide, obviously reducing the operation cost, simplifying the maintenance process, effectively treating byproducts and realizing double improvement of environmental protection and economic benefits.

The invention discloses an application of glycogen synthase kinase 3beta in preparation of antihypertensive drugs. The GSK3beta gene is inserted into a GV652 plasmid and is packaged into an adeno-associated virus, so that specific overexpression of the adeno-associated virus in vascular endothelial cells is realized, and the adeno-associated virus is used for preparing medicines for treating hypertension. It is found for the first time that overexpression of GSK3beta in endothelial cells can improve the endothelial dependent relaxation function and reduce blood pressure. Mechanism research shows that serine 9-site phosphorylation of GSK3beta can activate an AKT-eNOS signal channel and promote release of nitric oxide, so that the endothelial function is improved, and the antihypertensive effect is achieved. Furthermore, glycine can promote phosphorylation of the GSK3beta Ser9 site, and AKT-eNOS signal activation and NO generation are enhanced. The invention provides a novel anti-hypertension gene therapy strategy for regulating and controlling an endothelial function based on a GSK3beta gene.

This invention relates to the field of sensing technology, providing a method for preparing and applying a conductive nanofiber membrane. The preparation method includes: preparing a polycaprolactone / β-cyclodextrin / graphene composite nanofiber membrane by electrospinning; after amination treatment, sequentially constructing a conductive catalytic interface on its surface through gold seed adsorption and in-situ growth of gold nanowires; integrating the resulting functionalized membrane into the working electrode region of a three-electrode chip, and further bonding it with PDMS microfluidic channels to construct a biomimetic chamber. This invention combines a cell culture interface with an electrochemical sensing interface, enabling in-situ, real-time, and dynamic electrochemical monitoring of nitric oxide released by vascular endothelial cells in a microfluidic system simulating a physiological environment, providing an innovative technical means for real-time assessment of vascular endothelial function and related pathological research.

The present disclosure pertains to a molecule that is operable to release a nitroxyl (HNO) upon irradiation. The nitroxyl may be operable to convert to nitrous oxide (N2O). The present disclosure also pertains to methods of releasing nitroxyl from a molecule of the present disclosure by irradiating the molecule. The released nitroxyl may then convert to nitrous oxide. The present disclosure also pertains to methods of administering at least one of nitroxyl or nitrous oxide to a subject by (1) administering a molecule of the present disclosure to the subject; and (2) irradiating the molecule, where the irradiation results in the release of nitroxyl from the molecule. The released nitroxyl may then convert to nitrous oxide.

The utility model relates to the technical field of boiler flue gas treatment, in particular to dry SNCR (selective non-catalytic reduction) denitration equipment, which comprises a storage bin and a denitration furnace, the storage bin is connected with the denitration furnace through a pipeline conveying system, and a discharge plate is arranged between the inner walls of the storage bin. The discharging plate is slidably connected into a sliding groove correspondingly formed in the inner wall of the storage bin in an embedded mode through a T-shaped sliding block arranged on the inner wall of the discharging plate. According to the improved dry-method SNCR denitration equipment, the spray guns are annularly distributed in the denitration furnace in an equiangular mode, the number of the spray guns in the middle is larger than that of the spray guns in the upper area and the lower area, and spray gun pipe openings in different areas are obliquely distributed at different angles, so that a reducing agent can be sprayed into the furnace from different angles and uniformly cover the whole hearth space, the comprehensiveness and the uniformity of denitration reaction are improved, and meanwhile, the reduction effect is good. And the flow guide plate can change the flowing paths of the flue gas and the reducing agent, so that the retention time of the flue gas and the reducing agent in the furnace is prolonged, the reducing agent and nitric oxide can be more sufficiently subjected to selective non-catalytic reduction reaction, and the conversion rate of the nitric oxide is increased.