342 results about "Nitric oxide" patented technology

Nitric-oxide ionization induced flow tagging and imaging (NiiFTI) is described. In one embodiment a method for characterizing a flow of a gas containing an agent includes ionizing the agent by a source of pulsed light emitting at a frequency overlapping a resonant transition frequency of the agent. In response to ionizing of the agent, a fluorescence of the gas is generated. The method also includes capturing at least one time-delayed image of the flow of the gas, where the capturing is time-delayed with respect to a pulse of the source of pulsed light. The method includes determining at least one property of the flow of the gas by analyzing the at least one time-delayed image of the flow.

The invention relates to a medical device for evaluating physiological parameters of a respiratory system, and the device comprises a sampling device which is used for collecting detected exhaled gas after a rising inflection point of carbon dioxide; the gas sensor comprises a nitric oxide sensor and a carbon dioxide sensor; the processor is used for receiving the gas signal generated by the gas sensor; the processor is configured to establish a linear expression for calculating a risk parameter R according to the detected carbon dioxide concentration and nitric oxide concentration; the linear expression of the risk parameter R is shown in the specification; wherein the parameter is set as a constant; the parameter is nitric oxide concentration; the parameter is carbon dioxide concentration; and the parameter is a nitric oxide dynamic change rate function. Compared with the prior art, the method provided by the invention provides a more comprehensive evaluation capability for airway inflammation and abnormal ventilation.

The invention relates to the technical field of chemical plant smoke filtering, in particular to a chemical plant discharge filtering device with a monitoring function, which comprises a barrel, a gas inlet pipe, a gas outlet pipe and the like, the barrel is communicated with the gas inlet pipe, and the top of the barrel is communicated with the gas outlet pipe. Indexes of pollutants such as sulfur dioxide, nitric oxide, carbon monoxide and carbon dioxide in flue gas can be detected through the flue gas sensor, when the flue gas sensor detects that the pollutants in the flue gas exceed the standard, the controller can control an electric guide rail to work, the electric guide rail drives a first push plate to move forwards, and a first sealing plate can also move forwards; the first sealing plate seals the exhaust pipe, real-time response can be achieved after the filter element is aged and breaks down, the filter element is replaced without shutdown under the condition that it is ensured that smoke does not leak, smoke which is not completely purified is prevented from being exhausted out, and therefore pollution to the environment can be avoided.

The disclosure provides methods for the for treatment of psychosis, such as schizophrenia, or depression (such as bipolar depression) and / or anxiety, comprising administering to a patient in need thereof, (i) a 5-HT2A or 5-HT2A / D2 receptor ligand, for example a substituted heterocycle fused gamma-carboline as described herein, in free, pharmaceutically acceptable salt or prodrug form, and (ii) a nitric oxide donor, separately (sequentially or simultaneously), or in combination (e.g., in a fixed dose combination).

The invention relates to the technical field of biomedical materials, in particular to a double-network structure artificial blood vessel with anticoagulation, endothelium promotion and anti-infection functions and a preparation method of the double-network structure artificial blood vessel. The artificial blood vessel comprises a polymer fiber network artificial blood vessel substrate, a microscopic network hydrogel layer penetrating through the polymer fiber network artificial blood vessel substrate, and magnesium-copper alloy particles doped in the hydrogel layer. According to the artificial blood vessel with the double-network structure, the problem that a traditional small-caliber artificial blood vessel is insufficient in mechanical performance is greatly solved, copper ions and magnesium ions are released to the surrounding environment by means of degradation of the magnesium-copper alloy particles in the using process, the microenvironment of the surrounding tissue is adjusted to be alkalescent, nitric oxide is catalytically released, and the mechanical performance of the artificial blood vessel is improved. The artificial blood vessel with the double-network structure is endowed with anticoagulation, endothelium promotion and anti-infection functions. The problems of restenosis and insufficient endothelialization of a small-caliber artificial blood vessel in the prior art are comprehensively solved, and the long-term patency rate of the artificial blood vessel is increased.

The invention discloses a fluorescent probe as well as a preparation method and application thereof. The invention provides a series of fluorescent probes with novel structures, and the fluorescent probes take 2-(isoquinoline-1-yl) pyrrole boron difluoride as fluorophores, so that the fluorescence quantum yield of the probes is improved, the detection resolution of nitric oxide is increased, and the detection sensitivity is improved. The fluorescent probe disclosed by the invention has the characteristics of large Stokes displacement, high fluorescence quantum yield, good selectivity and short response time.

The invention discloses a giant salamander immune regulation meat peptide and application thereof. The meat peptide comprises one or more than two polypeptides selected from SEQ ID NOs: 1-5. The polypeptide can enhance cellular immune response, such as enhancing macrophage proliferation activity, improving macrophage nitric oxide secretion level, enhancing macrophage phagocytic ability, enhancing macrophage antigen presentation ability, enhancing immune organ functions, regulating T cell subpopulation, improving cellular immune factor level and enhancing immune globulin level.

The invention discloses a composition for preventing and treating eggplant root rot, and relates to the technical field of biological prevention and treatment. The composition consists of three parts, namely a double-stranded RNA (Ribonucleic Acid) delivery body controlled by a kaolinite nanotube-metal polyphenol network-boric acid ester, a nitric oxide / hydrogen sulfide double-pulse microcapsule and volatile organic compound particles of beta-cyclodextrin cross-linked aerogel, wherein the three parts are matched according to the total mass ratio of 1: (0.8-1.5): (0.8-1.2). Through structural design, time sequence release of non-overlapping peak values is realized, and a prevention and control mode for inhibiting environment enhancement host precise silencing is formed. The deliverer can be selectively disintegrated under the condition of pathogen-induced organic acid, iron chelating agent and hydrogen peroxide, so that the targeted release of the double-stranded RNA is realized; the double-pulse microcapsule respectively releases nitric oxide and hydrogen sulfide in a transplanting stress stage and an early disease stage, and induces host defensive gene expression; the aerogel particles continuously release 2, 3-butanediol and aromatic aldehyde to inhibit germination of pathogenic bacteria and serve as rhizosphere signals to enhance host resistance.

The invention belongs to the field of biological medicine and ultrasonic medicine, and provides a barium titanate (BTO) piezoelectric material-based ultrasonic responsive targeting nano system (BTO at BAL), which is used for matrix microenvironment remodeling and immunopotentiation of compact tumors such as pancreatic cancer and the like. According to the nanoparticles, oleic acid modified BTO is taken as a core, ROS responsive prodrug molecules containing a small molecule PD-L1 inhibitor BMS1166 and a nitric oxide donor (Arg) 9 are loaded on the surface, and specific targeting on pancreatic cancer cells is realized by combining a targeting peptide LFC131. Under ultrasonic excitation, BTO generates reactive oxygen species (ROS), on one hand, (Arg) 9 is oxidized to release NO, tumor matrix is degraded, tumor hardness is reduced, drug delivery efficiency is improved, and meanwhile, ROS and NO synergistically enhance tumor immunogenicity; on the other hand, the ROS breaks a thioketal bond to release BMS1166, PD-L1 expression is down-regulated, and immunosuppression is reversed. According to the present invention, the significant tumor inhibition and immune activation effects are represented in the animal model, and the clinical transformation potential is provided.

The invention discloses an intelligent quintuplet cooperative plasma self-purification robot long-term storage system and a self-adaptive disinfection control method. According to the system, cold plasma, ozone, chlorine dioxide, self-generated nitric oxide and a charge self-purification jump effect are fused, and a dynamic self-purification system with an electric field-gas field-chemical field-intelligent field-thermal field five-dimensional synergistic energy field is constructed. The robot adopts a three-section structural layout and a multi-mode self-adaptive propulsion mechanism, environmental parameters are sensed through AI, discharge power and oxidant release are intelligently regulated and controlled, and precise sterilization, toxicity reduction and mildew prevention in a multi-medium environment are achieved. The system can generate various high-energy active species containing. OH, O, NO, ClO, ONOO and the like, chain splitting decomposition and oxidation mineralization are carried out on mold spores, bacterial cells, aflatoxin and the like, the sterilization rate reaches 99.995%, and the toxin degradation rate exceeds 98%. The system has the characteristics of no residue, low energy consumption, long-acting self-maintenance and the like, is suitable for multiple scenes of grain storage, traditional Chinese medicinal materials, cold chains, farmland, public health and the like, and realizes an intelligent, continuous and chemical-additive-free green storage and dynamic purification system.

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract. The disclosed method can be effected while monitoring one or more of on-site and off-site parameters such as vital signs, methemoglobin levels, pulmonary function parameters, blood chemistry and hematological parameters, blood coagulation parameters, inflammatory marker levels, liver and kidney function parameters and vascular endothelial activation parameters, such that no substantial deviation from a baseline in seen in one or more of the monitored parameters.

Disclosed herein is a method for treating skin wounds in a patient in need of such treatment, comprising applying a foamed composition comprising nitric oxide to the area of skin requiring such treatment. The wound may be selected from the group consisting of skin ulcers, including diabetic foot ulcers (DFUs), venous leg ulcers (VLUs), arterial ulcers, decubitus (pressure) ulcers or other pressure injuries, deep tissue injuries (DTIs), burns, abrasions, skin tears, or bruises.

The invention provides a nitric oxide fluorescent probe with aggregation-induced emission characteristics and a preparation method and application thereof. The structural formula of the nitric oxide fluorescent probe is shown in the specification. The nitric oxide fluorescent probe provided by the invention is high in detection sensitivity, high in response speed, excellent in NO selectivity and AIE characteristic, wide in application range, not only suitable for liquid-phase and gas-phase NO detection, but also capable of realizing high-efficiency real-time detection of NO in body fluid, cells and living body samples, and wide in application prospect. The method can be used for diagnosis of diseases such as inflammation (rheumatoid arthritis), tumor microenvironment and the like, high-throughput drug screening and environment monitoring.

The invention provides a self-adaptive multifunctional hydrogel system for cardiac microenvironment regulation after myocardial infarction as well as a preparation method and application of the self-adaptive multifunctional hydrogel system, and belongs to the technical field of biomedical materials. The hydrogel system is hydrogel prepared by taking a micromolecular cross-linking agent, a polymer matrix and drug-loaded microspheres as raw materials. The hydrogel can realize staged response drug release in oxidative stress, inflammation and fibrosis microenvironments after myocardial infarction, has good injectability and self-healing property, and has the functions of ROS removal, nitric oxide release and the like. The invention provides a new strategy for tissue repair after myocardial infarction with multi-channel collaboration and accurate pathological response control.

The utility model discloses a nitric acid production unit and device, and relates to the technical field of nitric acid production equipment. The nitric acid production unit comprises an air compressor, a nitric oxide compressor, an expansion machine and a driving module, the driving module comprises a driving machine and at least two first-stage transmission shafts, the at least two first-stage transmission shafts are connected with the driving machine and provided with at least three first-stage connecting ends, and the first-stage connecting ends are connected with the driving machine. And the first-stage connecting end is correspondingly connected with one or two of the air compressor, the nitrogen oxide compressor and the expansion machine. The nitric acid production unit provided by the utility model is more compact in structure and smaller in size.

The utility model discloses a diesel generator flue gas purification mechanism for civil air defence engineering, including air inlet pipe and purification bin, the air inlet pipe one end is linked with diesel generator exhaust pipe in civil air defence engineering power generation room intercommunication, the other end of air inlet pipe is inserted into the purification bin and the opening direction is perpendicular to downward, the open end position of air inlet pipe in the purification bin is connected with the shunt joint, each interface of shunt joint all is connected with the jet pipe that the air hole of pipe body lateral wall is evenly set up, the utility model relates to civil air defence engineering technical field, utilize liquid supply booster pump and press into the spray subassembly in alkaline solution (15% magnesium hydroxide compound agent), and further via spray subassembly to the spray of filler layer, make the nitrogen monoxide, nitrogen dioxide, sulfur dioxide and particulate matter etc. in tail gas contact with the alkaline water mist in purification bin and filler layer, to the purification treatment of nitrogen monoxide, nitrogen dioxide, sulfur dioxide and particulate matter.

The invention discloses a Streptomyces rochei D74 homogeneous polysaccharide and a preparation method and application thereof.The Streptomyces rochei D74 homogeneous polysaccharide is obtained by smashing Streptomyces rochei D74 mycelia obtained through liquid fermentation, then conducting water extraction, concentration, alcohol precipitation and deproteinization to obtain crude polysaccharide, and further conducting ion-exchange chromatography, dialysis and gel column chromatography purification to obtain the Streptomyces rochei D74 homogeneous polysaccharide. The method is simple and efficient, and the obtained streptomyces homogeneous polysaccharide remarkably inhibits proliferation of human gastric cancer cells SGC-7901 by inducing tumor cell apoptosis; meanwhile, immune cells RAW264.7 can be activated, the phagocytic ability and the nitric oxide (NO) release ability of the immune cells RAW264.7 can be improved, and the polysaccharide can become a potential polysaccharide drug for treating human liver cancer.

This invention provides a gas-phase molecular absorption spectrometry-naphthylethylenediamine hydrochloride spectrophotometric method for determining total nitrogen in waste gas from stationary pollution sources. The method comprises the following steps: S1. Reacting the waste gas with an oxidant; S2. Using an absorbent, further reacting the waste gas after S1; S3. Collecting the oxidant after S1, pretreating it to reduce nitrogen-containing compounds to nitric oxide, and detecting the total nitrogen content I; S4. Collecting the absorbent after S2 to obtain the total nitrogen content II; S5. Summing the total nitrogen content I and total nitrogen content II to obtain the total nitrogen content in the current waste gas. This method enables accurate determination of total nitrogen in waste gas from stationary pollution sources.

This invention discloses a hydrogel for tumor treatment based on improving the tumor microenvironment to trigger gas therapy combined with chemotherapy, belonging to the field of biomedical technology. The hydrogel drug delivery system utilizes lipopolysaccharide (LPS) to induce local inflammatory stimulation, thereby altering the tumor microenvironment of breast cancer and promoting nitric oxide (NO) production. The NO donor arginine (L-Arg) and the chemotherapy drug doxorubicin (DOX) are transported using sodium alginate (ALG), achieving combined gas therapy and chemotherapy to inhibit breast tumor growth. The drug delivery system of this invention not only enhances the effect of chemotherapy but also simultaneously achieves precise drug delivery and reduces drug dosage. The preparation method of the drug delivery system of this invention is simple, safe, and without toxic side effects, showing promising application prospects in tumor treatment and possessing significant clinical value.

The invention relates to hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the hydrogel, and belongs to the technical field of hydrogel dressings. The invention discloses an exosome hydrogel, which is characterized in that exosome is loaded in crosslinked aldehyde hyaluronic acid and carboxymethyl chitosan, the aldehyde hyaluronic acid is grafted with L-arginine, and the exosome is derived from bone marrow mesenchymal stem cells. L-arginine can release nitric oxide under the action of a diabetic wound surface or an inflammation microenvironment to achieve the effects of resisting bacteria and promoting wound surface recovery, and the exosome successfully avoids the risks of cell survival defects, vascular embolism, immunological rejection and the like while retaining powerful bioactive components. The product has excellent antibacterial activity, degradability, tissue adhesion, injectable performance and self-repairing performance, and can be suitable for wounds in different shapes.

The preparation method of the camellia oil fermentation product comprises the following steps that a fermentation base solution containing camellia oil and a strain seed solution are mixed, the strain seed solution comprises at least one of lactobacillus plantarum and saccharomyces cerevisiae, fermentation culture is conducted, and the camellia oil fermentation product is obtained. The fermentation liquor containing the camellia oil leavening is obtained. Compared with a camellia oil fermentation product obtained by fermenting other strains, the camellia oil fermentation product provided by the scheme has higher antioxidant activity (DPPH and ABTS free radical scavenging ability), has stronger ability of inhibiting cells from spontaneously generating NO (nitric oxide), shows good biocompatibility in a cell experiment, and can be used for preparing a camellia oil fermentation product. The obvious adverse effect on the cell activity is not generated.

The invention discloses a construction method of a coronary artery microcirculation disturbance cell model, and belongs to the technical field of biological medicine. According to the method, mouse heart microvascular endothelial cells (MCMEC) are taken as objects, tetrachlorohydroquinone (TCHQ) is used for treating for 6 hours at the concentration of 20-40 [mu] M, and CMD typical characteristics such as apoptosis, increase of reactive oxygen species (ROS), reduction of nitric oxide (NO) and release of inflammatory factors (TNF-alpha and IL-1beta) of the cells are induced. The TCHQ is applied to construction of the CMD model for the first time, and the model is stable, good in repeatability and capable of being used for CMD pathogenesis research and drug screening.

The application relates to a carrier-free self-driven nanomotor and a preparation method and application thereof, and belongs to the technical field of biological medicines. The nanomotor is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force, or is a nanometer assembly formed by co-assembly of a photothermal / light motion dual-enhanced photosensitizer and a near-infrared light response type nitric oxide donor BNN6 through intermolecular force and modified by a polyethylene glycol modifier. The application realizes a synergistic treatment mode of deep tumor penetration and high-efficiency killing by constructing a functional coupling system of "photothermal driving-NO release-motion enhancement-RNS cascade generation".

This disclosure provides a system and method for non-invasively delivering ultrasound (US) pulses to a target site in a subject. The target site is either a blood vessel or blood-flowing tissue. By delivering US pulses to the target site, a therapeutic process in the body is facilitated. This therapeutic process is typically associated with the production of nitric oxide molecules induced by ultrasound irradiation. This disclosure provides a solution combining a US transducer with one or more sensors. The sensors can detect parameters indicating whether the US transducer is properly coupled and positioned to the subject's body site, enabling safe application of US pulses, or whether the subject and / or target area are in a state to tolerate ultrasound irradiation.

The application discloses a kind of crossflow multi-stage adsorption denitration device and denitration method, including adsorption tower, adsorption tower includes multiple adsorption stages, adsorption tower is used for flue gas and adsorbent crossflow contact, the gas inlet end of adsorption tower is connected with pre-cooler by pipeline, the flue gas import end of pre-cooler is connected with the flue gas export end of boiler, the gas outlet end of adsorption tower is connected with ozone removal device by pipeline, the gas inlet end of adsorption stage is connected with ozone generator device by pipeline, the volume ratio of ozone and nitric oxide in the gas inlet end of each adsorption stage is not less than 1:1, the present application is by using molecular sieve adsorption nitrogen oxide, while maintaining the moderate excess of ozone, it is favorable for the molecular sieve in adsorption tower to fully adsorb nitrogen oxide in flue gas, and the excess ozone is reduced and decomposed by ozone removal device, to avoid the secondary pollution emission caused by excess ozone through flue gas emission to the environment.

The invention discloses a dual-channel fluorescent probe for simultaneously detecting nitric oxide and cysteine as well as a preparation method and application of the dual-channel fluorescent probe. The structural formula of the dual-channel fluorescent probe is shown in the specification. The invention also specifically discloses a preparation method of the dual-channel fluorescent probe and application of the dual-channel fluorescent probe in selective detection of NO and Cys, dynamic visual detection of NO and Cys in a biological cell system and in ferroptosis and depression cell models. The dual-channel fluorescent probe disclosed by the invention has the advantages of strong specificity, good selectivity, no spectrum crosstalk and the like.

The invention discloses flammulina velutipes polysaccharide nano-liposome as well as a preparation method and application thereof, and belongs to the technical field of biological functional materials. The preparation method specifically comprises the following steps: (1) sequentially performing hot water extraction, deproteinization, alcohol precipitation, dialysis and freeze-drying on flammulina velutipes raw material powder; (2) dissolving in a phosphoric acid buffer solution; (3) mixing and dissolving phospholipid, cationic lipid and a membrane regulator in an organic solvent; (4) mixing and ultrasonic treatment; and (5) carrying out reduced-pressure rotary evaporation, hydration with a phosphate buffer solution, ultrasonic treatment and extrusion. According to the flammulina velutipes polysaccharide nano-liposome and the preparation method thereof, cholesterol is replaced by phytosterol ester to prepare the flammulina velutipes polysaccharide nano-liposome, flammulina velutipes polysaccharide (FVP) is encapsulated in a water core in the liposome, the safety is higher, and the encapsulation efficiency, the storage stability and the immunocompetence of a system are improved. In-vitro experiments prove that the phytosterol ester lipidosome has the effect of promoting macrophage proliferation and nitric oxide generation, and the effect is obviously better than that of the traditional cholesterol lipidosome under the same condition.

The utility model discloses a nitric acid production unit and device, and relates to the technical field of nitric acid production equipment. The nitric acid production unit comprises an air compressor, a nitric oxide compressor, an expansion machine and a driving module, the driving module comprises a driving machine and two first-stage transmission shafts, and the two first-stage transmission shafts are connected with the driving machine; wherein one first-stage transmission shaft is connected with one of the air compressor, the nitrogen oxide compressor and the expansion machine, and the other first-stage transmission shaft is correspondingly connected with the rest one or two of the air compressor, the nitrogen oxide compressor and the expansion machine. According to the nitric acid production unit, the axial length of the nitric acid production unit is shortened, the use number of couplings is reduced, the torsional vibration problem is greatly reduced, and the stability and reliability of the whole nitric acid production unit are greatly improved.

The invention belongs to the technical field of adsorption materials, and particularly relates to a hydroxyl-free lead dioxide-based nitric oxide absorbent and a preparation method thereof. The method comprises the following steps: preparing a mixed solution of perchloric acid and lead perchlorate, standing to form a saturated solution, and performing electrodeposition by using the saturated solution as an electrolyte to obtain a lead dioxide deposition layer; and cleaning, drying and crushing the sediments, drying the sediments in an air dry oven with an air exchange function, and calcining the sediments at high temperature to form a target product. The obtained absorbent has the characteristics of hydroxyl-free structure, nanoscale particle size, high porosity, excellent adsorption performance and the like. Test results show that the absorbent has good selective adsorption capacity on NO2, and the adsorption efficiency can reach 85% or above. The material is suitable for nitrogen oxide interference absorption in the determination process of the hydrocarbon content in coal, and has important application value.

The invention discloses a flue gas treatment system and a flue gas treatment method for low-temperature desulfurization and denitrification by using red mud as a catalyst, and belongs to the technical field of flue gas purification. The device comprises a red mud drying and grinding kiln, a cloth bag reactor, a washing tower, a softening tower, a dust remover, a filter, an evaporator and the like. The method mainly comprises the following steps: removing dust from raw flue gas through a dust remover, feeding the flue gas into a drying and grinding kiln, enabling the flue gas to be in full contact with red mud with relatively high moisture in the drying and grinding kiln, drying the red mud, and absorbing redundant sulfur dioxide in the red mud dust by the red mud. Red mud dust is intercepted on the surface of a cloth bag after entering a cloth bag reactor, red mud reacts with nitric oxide and sulfur dioxide in flue gas, the red mud powder is discharged into a washing tower to be fully stirred and then is subjected to desulfurization and denitrification reaction again, and a solution is subjected to oxidation, desalination, softening and evaporation treatment and then is subjected to resource utilization again. The device is lower in energy consumption and simpler in structure, and solid waste resources are recycled.