530 results about "Asthma" patented technology

The invention provides a small sample respiratory disease pattern recognition method based on a diffusion model. The method comprises the following steps: firstly, for common respiratory disease types, collecting and classifying data of three respiratory modes: normal respiration, pause respiration and deep respiration which respectively correspond to respiratory diseases such as normal respiration, obstructive apnea and asthma in medicine; secondly, learning an internal distribution rule of data by using a radio frequency diffusion model, and generating diversified and high-quality radio frequency time sequence data on the basis of limited real samples so as to expand a data set; and thirdly, combining the generated data with real data, extracting an accurate respiration signal through a one-dimensional time sequence extraction algorithm, and converting a time sequence into a two-dimensional image by utilizing a Gramian Angle Field (GAF) method, so that the time dependency relationship of the time sequence is intuitively presented in the image. And finally, a convolutional neural network (CNN)-Transform deep learning model is adopted to carry out feature extraction and classification on the image data, and then multi-scale feature analysis and breathing mode recognition are carried out. According to the method, the recognition precision and generalization ability of the model are remarkably improved under the small sample condition, and an accurate and reliable solution is provided for non-contact breathing mode recognition.

To provide a device and a method for treating at least one of hypertension, pulmonary arteries, diabetes, obesity, heart failure, end-stage renal disease, digestive disease, urological disease, cancers, tumors, pain, asthma or chronic obstructive pulmonary disease by delivering an effective amount of a formulation to a tissue.SOLUTION: In embodiments of the present invention, the formulation may include at least one of a gas, a vapor, a liquid, a solution, an emulsion or a suspension of one or more ingredients. In embodiments of the present invention, amounts of the formulation and / or energy are effective in injuring or damaging tissue, nerves and nerve endings in order to relieve disease symptoms.SELECTED DRAWING: Figure 3B

The invention relates to the technical field of traditional Chinese medicine, in particular to a Mongolian medicine tea drink for relieving respiratory system abnormality and a preparation method and application thereof.The Mongolian medicine tea drink is prepared from rhododendron micranthum, pomegranate, amomum cardamomum, long pepper, cinnamon, safflower, agilawood, clove, myristica fragrans, fructus choerospondiatis, bistort rhizome, liquorice, tabasheer, radix aucklandiae, white raisin and crabs. The processed products of the Mongolian medicine components are weighed according to the formula dosage, then ground into coarse powder and bagged to prepare tea bags. The Mongolian medicine tea drink provided by the invention has the effects of moving Heli, relieving cough, reducing phlegm and diminishing swelling; the traditional Chinese medicine composition can be used for treating the symptoms such as' Bada dry Hiri 'dizziness, asthma, chronic bronchitis, indigestion disease, edema, edema and water tympanites.

Described herein are novel and improved antibodies that bind to thymic stromal lymphopoietin (TSLP) and methods of use thereof. In certain aspects, described herein are methods of inhibiting TSLP biological activity. In certain aspects, the antibodies and methods described herein are used for treatment of an inflammatory disease or disorder associated with elevated levels of TSLP. In certain aspects, described herein are methods of treating asthma by administering anti-TSLP antibodies.

The invention relates to the field of biological medicine, and discloses a method and system for analyzing cough sound by using disease characteristics to diagnose respiratory diseases, and the method comprises the steps: deploying a six-microphone annular array to achieve the precise positioning and triggering of a sound source; self-adaptive spectral subtraction and Wiener filtering cascade are adopted to enhance the audio; segmenting a cough segment based on energy envelope; fusing the Mel-cepstrum, the linear prediction residual error, the harmonic energy ratio and the transient zero-crossing rate to construct a pathological feature matrix; extracting local, medium-range and global time sequence features through a three-branch parallel convolutional network; inputting a disease specific classifier to discriminate asthma, pneumonia and laryngitis respectively, and applying a feature decoupling regular term to improve interpretability. The system correspondingly realizes the modularized processing flow. According to the method, the cough sound collection quality and the disease subtype recognition accuracy in a complex environment are improved, meanwhile, the thermodynamic diagram is output to assist clinical decision making, and the diagnosis credibility and practicability are enhanced.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

The present disclosure provides chimeric antigen receptors, compostions, and methods thereof. In one embodiment the present disclosure provides a method of treating autoimmune diseases, asthma, and preventing or mediating organ rejection in a subject.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and / or other pulmonary diseases or disorders.

Apparatus and methods for deactivating bronchial nerves and ablating smooth muscle extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits ultrasound so as to heat tissues throughout a relatively large impact volume (13) to a temperature sufficient to inactivate nerve conduction and ablate smooth muscle but insufficient to cause rapid ablation or necrosis of the surrounding tissues. The treatment can be performed without locating or focusing on individual bronchial nerves or smooth muscle.

Described herein are antibodies that bind Interleukin 4 Receptor alpha (IL-4Rα) and methods of use thereof. In certain aspects, described herein are methods of inhibiting IL-4Rα biological activity. In certain aspects, the antibodies and methods described herein are used for treatment of an inflammatory disease or disorder associated with elevated levels of IL-4 and / or IgE. In certain aspects, described herein are methods of treating asthma by administering anti-IL4Rα antibodies.

The invention relates to an anti-canine IL-31 antibody or an antigen binding part thereof and application thereof, and belongs to the technical field of antibody preparation. The invention relates to an anti-canine interleukin-31 antibody or an antigen binding part thereof, amino acid for coding the antibody or the antigen binding part thereof, polynucleotide, a carrier containing the polynucleotide, a host cell containing the polynucleotide or the carrier, a method for preparing and purifying the antibody and application of the antibody or the antigen binding part thereof. The anti-canine IL-31 antibody disclosed by the invention can be specifically combined with a canine IL-31 antigen, and can effectively relieve symptoms such as pruritus, allergy, nasal polyp or asthma and the like. The mutated anti-canine IL-31 antibody also has a corresponding function of combining with the antigen canine IL-31, and also can be used for treating IL-31 related diseases.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for relieving cough and asthma, and a preparation method and application thereof. The traditional Chinese medicine composition comprises, in mass parts, perilla seed 5-15 parts, radish seed 5-15 parts, white mulberry bark 5-15 parts, orange red or processed orange red 5-15 parts, and cassia 5-15 parts. The traditional Chinese medicine composition has the effect of relieving cough and asthma, can effectively improve the clinical symptoms such as cough, expectoration and wheezing of patients with chronic obstructive pulmonary disease, promote lung rehabilitation, improve the dyspnea condition of the patients, and improve the life quality of the patients.

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue damage, the treatment of evolving myocardial infarction, the treatment of ischemic injury, and the treatment of various other disorders, such as complications arising from diabetes with the compounds and compositions of the invention. Other disorders can include, but are not limited to, atherosclerosis, coronary artery disease, diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, diabetic cardiomyopathy, infections of the skin, peripheral vascular disease, stroke, asthma, and the like.

The invention discloses a children cough variant asthma diagnosis system based on a decision tree, and relates to the technical field of asthma diagnosis, the children cough variant asthma diagnosis system comprises a diagnosis management platform, the diagnosis management platform is in communication connection with a data acquisition module, a diagnosis model construction module, a diagnosis reasoning module and an intervention suggestion module, and the modules are in electric signal connection; the data acquisition module is used for collecting and preprocessing child patient clinical data including symptoms, signs, medical history and multi-dimensional examination data. By integrating the multi-dimensional examination data and the medical history, symptom change trend and family history information of the child patient, the condition of the child patient can be comprehensively and deeply analyzed, reasoning and judgment are performed by applying a branch structure of a decision tree and accurately combining various characteristics, so that subjective and empirical deviations in a traditional diagnosis method are effectively avoided, and the diagnosis accuracy is improved. The accuracy of CVA diagnosis is remarkably improved, a child patient is helped to obtain correct treatment in time, and misdiagnosis and missed diagnosis can be effectively reduced.

The invention provides agonistic TNFR2 antibodies and antigen-binding fragments thereof and encompasses the use of these antibodies as therapeutics to promote the proliferation of regulatory T cells (T-reg) for the treatment of immunological diseases. Antibodies of the invention can be used to potentiate the T-reg-mediated deactivation of self- and allergen-reactive T- and B-lymphocytes, and can thus be used to treat a wide variety of indications, including autoimmune diseases, allergic reactions, asthma, graft-versus-host disease, and allograft rejection, among others.

Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either or both the sympathetic afferent and efferent nerves lying within the paravertebral gutter including the visceral fibers that travel to the cardiothoracic cavity and abdominopelvic viscera and the T1 to T4 / 5 sympathetic chain. In another embodiment, an intravascular instrument may be advanced to the bronchial vessels to ablate either or both the sympathetic afferent and efferent nerves in and around the posterior pulmonary plexus. In one embodiment the ablative agent is a neurolytic agent delivered in a gel. This approach may be utilized to treat other cardiac and pulmonary diseases.

The invention provides an application of alpha-melanocyte stimulant in treating asthma by inhibiting type II innate lymphocytes. An IL-7R-STAT pathway in activated lung ILC2 is inhibited through an alpha-MSH-MC5R axis, it is found that the neuroendocrine hormone alpha-MSH can target ILC2 to limit lung inflammation, and screening of new drugs for treating lung inflammation is facilitated.

The invention discloses an intelligent respiratory disease detection system based on lung function measurement indexes, and relates to the technical field of intelligent medical detection. The problems that diagnosis standards are not uniform and depend on experience, primary doctors are prone to missed diagnosis or misdiagnosis due to insufficient experience, and the efficiency of the detection process is low are solved. According to the method, a machine learning model is constructed based on lung function indexes, parameters are optimized through five-fold cross validation, automatic classification of asthma, COPD and ILD / DPLD is achieved, the overall diagnosis accuracy rate reaches 81.3%, the limitation that traditional diagnosis depends on doctor experience is broken through, and the basic medical diagnosis capacity is especially improved. Healthy people are rapidly eliminated through the FVC / FEV1 ratio, invalid calculation is reduced, meanwhile, multi-model weighted fusion is adopted for complex cases, diagnosis robustness is improved, it is ensured that diagnosis results conform to medical logic, the recognition degree of doctors is enhanced, a data basis is provided for clinical research and curative effect tracking, and respiratory disease diagnosis is promoted to develop towards the direction of automation and precision.

The present disclosure relates to methods of treating a subject suffering from an eosinophil-associated chronic obstructive pulmonary disease (COPD) or asthma-COPD overlap (ACO) using compounds that bind to CD131 and inhibit signalling of interleukin (IL) 3, IL-5 and granulocyte-macrophage colony stimulating factor (GM-CSF).

The invention belongs to the field of traditional Chinese medicines, mainly relates to a traditional Chinese medicine ointment and a preparation process thereof, and particularly relates to a traditional Chinese medicine ointment for clearing heat, relieving cough and reducing sputum and a preparation process thereof. According to the invention, indigo naturalis, cortex lycii radicis, gypsum, scutellaria baicalensis, radix stemonae, tabasheer, raw ephedra, platycodon grandiflorum and lalang grass rhizome are used as a traditional Chinese medicine prescription, glycerin monostearate, paraffin, liquid paraffin, albolene, span 80, an OP emulsifier, chlorocresol and distilled water are used as auxiliary materials, bacillus megatherium CICC 24484 and aspergillus oryzae CICC2066 are used for carrying out synergistic fermentation on platycodon grandiflorum and lalang grass rhizome, and then decoction is carried out for multiple times. The traditional Chinese medicinal materials are more beneficial to exerting the effects, the traditional Chinese medicinal composition has important significance for treating symptoms such as cough and excessive phlegm caused by internal heat, and meanwhile, an unexpected effect of relieving asthma is shown due to synergistic fermentation.

Provided herein are methods for treating a disease or condition associated with one or more of: mtDNA fragmentation; cytostolic Ox-mtDNA; mtDNA release; or Casp1 activation and IL-1β production by administering an effective amount of an inhibitor of human flap endonuclease-1 (FEN1). These diseases include without limitation, an inflammatory or a neurodegenerative disease, such as Alzheimer's, disease, Parkinson's disease, atherosclerosis, NASH, asthma, inflammatory bowel disease, melanoma, metabolic pathologies, including obesity, type 2 diabetes, atherosclerosis, inflammatory bowel diseases, gout, and periodic fevers.

The invention provides a traditional Chinese medicine composition for relieving cough and asthma and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5-15 parts of herba ardisiae japonicae, 5-15 parts of honey-fried folium eriobotryae, 1-3 parts of honey-fried herba ephedrae, 2-5 parts of semen armeniacae amarae, 1-5 parts of roselle, 2-6 parts of mint, 2-6 parts of pericarpium citri reticulatae, 2-6 parts of caulis bambusae in taeniam, 4-12 parts of herba houttuyniae and 1-3 parts of honey-fried licorice root. The herba ephedrae is changed into the honey herba ephedrae, and the roselle is added, so that the product is weakened in sweating effect and more prominent in lung moistening and cough relieving, and is more suitable for weak people to use, and the applicable crowd is widened; meanwhile, a hydrotropy technology is adopted in the production and use process, so that the solubility of traditional Chinese medicine components is improved; the traditional Chinese medicine composition is taken after being mixed with warm water, solves the problem of overhigh alcohol content in the original product, is convenient to carry and adjustable in administration dosage, and is convenient for children and patients to use.

The present invention provides a composition for use in the prevention and / or treatment of a viral infection in an individual wherein the composition comprises Bifidobacterium longum subsp. Infantis and a mixture of HMO consisting of 2 '-fucosyllactose (2FL), difucosyllactose (DFL), lactose-N-tetraose (LNT), 6'-sialyllactose (6SL), 3 '-sialyllactose (3SL), and 3-fucosyllactose (3FL). The present invention also provides compositions for use in preventing and / or reducing the risk of allergen sensitization, preventing and / or reducing the risk of developing respiratory disorders in an individual, and / or preventing and / or reducing the risk of developing asthma in an individual.

The invention belongs to the technical field of traditional Chinese medicine, and discloses a pediatric breathing plaster traditional Chinese medicine composition and a preparation method thereof, and the technical scheme is characterized in that the traditional Chinese medicine composition is prepared from the following raw medicinal materials in parts by weight: 80-120g of radix peucedani, 80-120g of pericarpium citri reticulatae viride, 80-120g of roasted aster, 40-60g of mint and 25-35g of asarum. According to the breathing plaster, the medicine with the spicy moving property is applied to the corresponding acupuncture point, and the overall function of the internal organs of the human body is adjusted through the stimulation effect of the medicine, the skin permeation effect and the channel tropism property of the acupuncture point, so that the treatment purpose is achieved. The traditional Chinese medicine composition has a good treatment effect on cough and asthma and asthma in the remission period and is suitable for children of all ages.

The present invention relates to a composition comprising a Bifidobacterium longum transitional microorganism and a mixture of human milk oligosaccharides (HMOs) consisting of 2'-fucosyllactose (2'-FL), difucosyllactose (DFL), lacto-N-tetraose (LNT), 6'-sialyllactose (6SL), and 3'-sialyllactose (3SL), and optionally lacto-N-fucopentaose I (LNFP-I), 3- fucosyllactose (3-FL) and / or lacto-N-neotetraose (LNnT), wherein the Bifidobacterium longum transitional microorganism has an Average Nucleotide Identity (ANI) of at least 98% with CNCM I-5942. The invention also relates to the use of the composition for preventing, reducing the risk of and / or treating an infection in a subject. The invention also provides the composition for use in promoting a long-term immune benefit in a subject, preventing and / or reducing the risk of allergen sensitisation, preventing and / or reducing the risk of developing a respiratory condition in a subject, and / or preventing and / or reducing the risk of developing asthma in a subject.

The disclosure herein relates to the development and production of novel antibodies and antigen binding fragments thereof that bind TL1 A and that are useful in the treatment, prevention and diagnosis of a disease, disorder or inflammation including, for example, autoimmune diseases including rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, systemic lupus erythematosus, asthma, ulcerative colitis, Crohn's disease, psoriasis, primary biliary cirrhosis, primary biliary cholangitis, ankylosing spondylitis, and fibrosis including intestinal fibrosis, pulmonary fibrosis, and liver fibrosis. Some of the elements of final antibody structure being designed de novo by a computer system and its data training set without reference to a specific reference molecule.

The utility model provides a neck treatment device which comprises a main body and arm bodies connected to the two ends of the main body respectively, the main body comprises a main shell, a first irradiation hole is formed in the face, facing the neck, of the main shell, and a first lamp panel, a first cooling fin, a power supply piece and a driving plate are arranged in the main shell; the light-emitting side of the first lamp panel corresponds to the first irradiation hole, the first cooling fin is arranged on the backlight side of the first lamp panel, a second irradiation hole is formed in the face, facing the neck, of the arm shell, a second lamp panel and a second cooling fin are arranged in the arm shell, and the light-emitting side of the second lamp panel corresponds to the second irradiation hole. The first cooling fin is arranged on the backlight side of the first lamp panel, the second cooling fin is arranged on the backlight side of the second lamp panel, a plurality of light emitters are arranged on the first lamp panel and the second lamp panel, the light emitters are red and blue light lamp caps, and the first lamp panel, the second lamp panel and the power supply part are electrically connected with the driving plate in sequence. The lamp panel performs illumination physical therapy on acupuncture points of the neck through the irradiation window, so that the effects of effectively relieving strong neck pain, post headache, occipital neuralgia, neck muscle spasm and sprain, shoulder pain, cough, asthma and the like are achieved.

The invention relates to the technical field of biological medicine, in particular to a drug screening model construction method based on airway organs, a model and application. The construction method of the drug screening model of the airway organoid comprises the steps of obtaining 2D airway epithelial cells, culturing the airway organoid, establishing an airway organoid inflammation model and / or establishing an airway organoid mucus secretion / goblet cell metaplasia model. Wherein the model is established according to the culture mode of the airway organ in cooperation with a specific stimulant for proliferation and differentiation. Compared with a traditional animal model, the organ-like model is low in cost and short in construction period, can better simulate the pathological process, can realize airway organ-like culture and establishment of an inflammation model and a mucus secretion / goblet cell metaplasia model at the same time, and has a good application prospect in drug detection of asthma and COPD diseases.

The present invention relates to the use of an ROR inverse agonist or a pharmaceutically acceptable salt thereof for the preparation of a medicament for modulating ROR in a patient and / or for controlling autoimmune diseases and antibody-mediated rejection in a patient. The ROR-mediated diseases or autoimmune diseases include HIV, cancer, celiac disease, type 1 diabetes, Graves' disease (Graves' disease), inflammatory bowel disease, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, asthma, dermatitis, fatty liver disease, Crohn's disease (Crohn's disease), cardiovascular disease, inflammatory disease, nervous system disorders, multiple sclerosis, and the like. Acute respiratory distress syndrome and arteriosclerosis.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating gastroesophageal reflux cough and a preparation method thereof. The traditional Chinese medicine composition disclosed by the invention is constructed by carefully selecting a medicine formula under the guidance of a traditional Chinese medicine theory and clinical experience and through a compatibility theory of monarch, minister, assistant and guide of traditional Chinese medicines. In the traditional Chinese medicine composition, the inula flower has the effects of promoting blood circulation, removing stasis and turbidity, clearing the airway and removing phlegm and fluid retention, and the mangnolia officinalis has the effects of promoting qi circulation, removing food retention, calming adverse-rising energy and relieving asthma, and both serve as monarch drugs; the dried orange peel has the effects of regulating qi and removing stagnation, the poria cocos has the effects of tonifying spleen, eliminating dampness and phlegm and breaking up the source of phlegm, and the bulbus fritillariae cirrhosae has the effects of clearing heat and moistening lung and resolving phlegm and relieving asthma; the rhizoma atractylodis macrocephalae has the effects of invigorating the spleen, replenishing qi, eliminating dampness and inducing diuresis, and the endothelium corneum gigeriae galli has the effects of promoting digestion and invigorating the stomach and is an assistant and guide drug. The whole prescription is ordered in monarch and minister, focuses on pathogenesis, is rigorous in prescription, has the effects of relieving cough and asthma, clearing heat and moistening lung, and strengthening spleen and stomach, and treats both symptoms and root causes of cough.