233 results about "Bronchial tubes" patented technology

The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be from health data, clinical data, or from a biological sample, (e.g., a biological sample from a human, e.g., serum, blood, saliva, plasma, nipple aspirants, synovial fluids, cerebrospinal fluids, sweat, urine, fecal matter, tears, bronchial lavage, swabbings, needle aspirantas, semen, vaginal fluids, pre-ejaculate.), etc. which is analyzed to determine the biological state of the donor. The biological state can be a pathologic diagnosis, toxicity state, efficacy of a drug, prognosis of a disease, etc. Specifically, the invention concerns processes that discover hidden discriminatory biological data patterns (e.g., patterns of protein expression in a serum sample that classify the biological state of an organ) that describe biological states.

A method for controlling breathing gas flow of a ventilator for assisted or controlled ventilation of a patient as a function of a tracheobronchial airway pressure of the patient. A ventilator tube, such as a tracheal tube or tracheostomy tube, can be introduced into a trachea of the patient and subjected to the breathing gas, and has an inflatable cuff and at least one lumen that is continuous from a distal end of the tube to a proximal end of the tube. An apparatus detects an airway pressure, in which the tracheobronchial airway pressure is ascertained by continuous or intermittent detection and evaluation of an intra-cuff pressure prevailing in the cuff of the tube inserted into the trachea. The breathing gas flow of the ventilator is controlled as a function of the intra-cuff pressure detected.

Methods and devices for treating bronchial constriction related to asthma and anaphylaxis wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve and / or the lungs of a patient suffering from bronchial constriction.

By interposing an adapter between the endotracheal or tracheal tube inserted to a patient and the ventilation and suction systems that are connected to the endotracheal tube, a catheter could be inserted via an input port built into the adapter so as to enable a medical personnel to provide localized treatments in the lungs of a patient without having to disconnect either one of the systems connected to the endotracheal tube. The adapter is configured to have a securing mechanism that allows the medical personnel to secure the medication catheter in place. A one way valve fitted to the apertured arm that forms the input port of the adapter prevents any back flow of fluid from the input port. The catheter is manufactured with calibration markings, most likely equally spaced, and a radiopaque line along its length to enhance the maneuvering and the positioning thereof in the patient so that the distal tip of the catheter could be accurately positioned to the desired location of the patient's tracheal / bronchial tree. As a result, the localized treatment such as the injection of a medicament is accurately provided to the appropriate location where the need is the greatest.

The invention relates to improvements in or relating to medicament delivery devices. In particular, this invention relates to a communications device which may be fitted to an electronic medicament delivery device. The invention may be particularly suitable for use with electronic medicament inhalers such as those used for the treatment of diabetes, or respiratory diseases such as asthma, COPD, cystic fibrosis, and bronchiectasis.

This invention relates generally to medical imaging and, in particular, to a method and system for reconstructing a model path through a branched tubular organ. Novel methodologies and systems segment and define accurate endoluminal surfaces in airway trees, including small peripheral bronchi. An automatic algorithm is described that searches the entire lung volume for airway branches and poses airway-tree segmentation as a global graph-theoretic optimization problem. A suite of interactive segmentation tools for cleaning and extending critical areas of the automatically segmented result is disclosed. A model path is reconstructed through the airway tree.

The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

An airway device for insertion into the trachea or bronchi of a human or animal, comprising an elongate flexible tube (10) having a distal end, a proximal end and a lumen therethrough, the device further comprising a cuff (11) located at or near the distal end of the flexible tube, wherein the cuff comprises an inner inflatable region (12) and an outer soft barrier region (13) adapted to prevent the walls of the airway coming into direct contact with the inner inflatable region when the cuff is in position and inflated.

An isolated heart or heart-lung preparation in which essentially normal pumping activity of all four chambers of the heart is preserved, allowing for the use of the preparation in conjunction with investigations of electrode leads, catheters, ablation methods, cardiac implants and other medical devices intended to be used in or on a beating heart. The system can be designed to be used within a Magnetic Resonance Imaging (MRI) unit or a X-ray computed tomography (CT) scanner. The preparation may also be employed to investigate heart and lung functions, in the presence or absence of such medical devices. In order to allow comparative imaging visualizations of either or simultaneously the heart and / or lung structures and devices located within the chambers of the heart or vessels or bronchi within the lungs, a clear perfusate such as a modified Krebs buffer solution with oxygenation is circulated through all four chambers of the heart and thus the coronary and / or pulmonary vasculatures. A ventilator with intubation tube can be used to inflate / deflate the lungs and / or provide oxygen to the isolated organs. The preparation and recordings of the preparation may be used in conjunction with the design, development and evaluation of devices for use in or on the heart and / or lungs, as well as for use as an investigational and teaching aid to assist physicians and students in understanding the operation of the cardiopulmonary system.

The invention relates to a degradable drug loading stent and a preparation method of the degradable drug loading stent. The degradable drug loading stent is characterized by comprising a skeleton structure made of a medical degradable metal or an alloy of the metal, a degradable macromolecular transition layer adhered to the surface of the skeleton structure and a drug loading layer. The degradable metal / macromolecular / drug multilayer composite stent provided by the invention has excellent mechanical property, degradable property and biocompatibility, and such drugs as taxol, taxol derivative, actinomycin D, 5-fluorouracil and sirolimus are loaded to the stent to perform active directional treatment on the focus position, so the stent is a functional degradable stent. The degradable multifunctional drug loading stent provided by the invention is suitable for interventional therapy in the blood vessel field and non-blood vessel fields and is especially suitable for interventional therapy of stenosis, obstruction or tumor of such non-blood vessel cavities as esophagus, bile duct, ductus pancreaticus, intestinal tract, urethral canal, trachea and bronchus, etc.

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.

The present invention provides a method and novel devices for treating tracheobronchitis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In a preferred embodiment, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.

The present invention relates to a method of predicting the risk of a subject developing a cardiovascular event, comprising determining the presence of a biomarker that is indicative of the risk of developing a cardiovascular event in exosomes from the subject. The exosomes are suitably isolated from a body fluid selected from serum, plasma, blood, urine, amniotic fluid, malignant ascites, bronchoalveolar lavage fluid, synovial fluid, breast milk, saliva, in particular serum. The biomarker is selected from the proteins Vitronectin, Serpin F2, CD14, Cystatin C, Plasminogen, Nidogen 2 or any combination of two or more of these proteins.

A retractable protective respiratory mask including disposable filters, which protects the respiratory system, covering the nose and mouth during inhalation while breathing in an atmosphere polluted by different agents, such as infectious, virulent, or pathogenic agents, or other toxic substances. The mask also protects non-infected persons from persons infected with a virus, as saliva and sputum expelled when coughing, breathing-out, and / or talking can be deposited inside the mask. The mask can include a collection-container filter, allowing a viral-infected wearer to breathe in a polluted atmosphere, to talk, to cough, to sneeze and / or to deposit saliva and sputum. The mask can be used as any other type of filter mask and / or disposable environmental air mask for industry in general, and also providing protection in rarefied natural atmospheres. The mask can be used as a container or packaging for drugs administered by means of bronchial airways, or as medical or rescue masks.

The embodiment of the invention provides a segmented naming method and system for lung tracheas and blood vessels, and the method comprises the steps: extracting a trachea center line of a lung, and building a trachea tree structure according to the trachea center line; lung lobe type division is carried out on the trachea of each branch in the trachea tree structure; and classifying the lung segment of each bronchial tube by adopting a first classifier corresponding to the lung lobe type of the trachea to obtain a lung segment naming result of each bronchial tube. According to the embodimentof the invention, the tracheal center line of the lung is extracted; establishing tracheal tree structure, according to the lung segment naming method, the lung segment of each bronchus is classifiedby adopting the first classifier corresponding to the lung lobe type of the trachea, and the lung segment naming result of each bronchus is obtained, so that the lung trachea can be automatically named segment by segment through the effectively established spatial topological structure of the human tubular organ, the segment naming efficiency is improved, and the error rate is reduced.

Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.

The invention relates to a bronchial puncture wall-breaking device, which comprises an outer sheath tube, a head of a guide head is in a pointed cone shape, the tail of the guide head is coaxially connected with the front end of the outer sheath tube in a fastened mode, and the guide head is hollow and communicated with the interior of the outer sheath tube to form a channel; a puncture needle isused for being coaxially arranged in the channel in a penetrating mode and can reciprocate in the outer sheath tube so as to stretch in or out of the head of the guide head. The bronchial puncture wall-breaking device can penetrate through the bronchus wall, a wound can be enlarged and deepened, a path from the bronchus wall to a target focus is artificially established, and a biopsy sample can beobtained.

The invention relates to a multifunctional balloon catheter integrated with a puncture needle and a system. The balloon catheter adopting unique design and the system can be used for different types of tumor such as benign and malignant bile duct stenosis, esophagus cancer, colorectal cancer, bronchogenic carcinoma, gastric antrum cancer, portal vein and vena cava tumor thrombus of primary hepatic carcinoma and the like, a far-end part where an eccentric balloon and the puncture needle are located is precisely put in the part where tumor of a lumen is located, a swelling balloon pushes the far end of the puncture needle to attach to the tumor, a near end of a rotating system operates a nut of the system and pushes the puncture needle to extend out of the catheter, the far end of the puncture needle with shape memory is bent and punctures the tumor, the puncture needle can be used for injecting a tumor treatment drug into the tumor to treat tumor or sucking tissue for biopsy or is used as a radiofrequency ablation electrode to perform radiofrequency ablation / heating to treat the tumor; on the basis of the system, with the adoption of different designs, the multifunctional balloon catheter can be used for injection of the treatment drug into atherosclerosis plaques and treatment of aortic dissecting aneurysm.

A method of determining potential treatment sites in a diseased lung is disclosed, in which an assessment catheter is introduced into a lung passageway. The catheter has a distal portion comprising an occluding member and a proximal portion configured to operatively mate with an external console. The catheter is used to identify one or more assessment sites within the airways of the lung. At each assessment site, at least one physiological, anatomical or biological characteristic is determined. A characteristic score for each assessment site is calculated based on a predetermined algorithm; and a treatment is determined based on the scores of the assessment sites. The algorithm takes into account several parameters including the disease characteristics as well as the number and proximity of each assessment site to at least one of the diseased regions. The method envisages treatment of emphysema, asthma or bronchopleural leak.

The present invention relates to the use of a compound of formula 3 or a salt thereof to prepare a medicament or phototherapeutic agent for treating the following diseases, including: acne; AIDS; viral hepatitis; diabetic retinopathy; SARS virus infection; coronavirus Arterial stenosis; carotid artery stenosis; intermittent claudication; Asian (chicken) avian influenza virus infection; cervical dysplasia or various cancers, including: blood cancer, cervical cancer, nasopharyngeal cancer, tracheal cancer, laryngeal cancer, bronchial cancer , bronchiolar cancer, bladder cancer, esophageal cancer, stomach cancer, rectal cancer, colon cancer, prostate cancer, hollow organ cancer, bile duct cancer, urinary tract cancer, kidney cancer, uterine cancer, vaginal cancer and other gynecological adnexal cancer. The present invention also relates to methods of treating the above diseases. The present invention further relates to the use of the compound of formula 3 or a salt thereof to prepare a photodiagnostic agent for detecting the above-mentioned diseases and the following diseases, including: atherosclerosis, multiple sclerosis, diabetes, arthritis, rheumatism Arthritis, fungal infections, viral infections, chlamydial infections, bacterial infections, or parasitic diseases, HIV viral infections, hepatitis, herpes simplex, shingles, psoriasis, cardiovascular disease, and skin diseases. The present invention also relates to methods for detecting the above diseases using photodiagnostic agents. The present invention further relates to a method for low-temperature sterilization of surgical devices or other devices, including the steps of: providing a compound of Chemical Formula 3 or a salt thereof on the device; and subjecting the device to radiation treatment or sonication treatment. The invention further relates to a compound of formula 3 or a salt thereof linked or attached to a magnetic element. This compound acts as an MRI enhancer. The invention also relates to the use of such MRI enhancers for performing MRI scans.

A pharmaceutical combination comprising (a) a combination of two or more bronchodilators; or (b) a combination of at least one bronchodilator in combination with at least one corticosteroid.

The invention belongs to the field of bronchoscope intervention, and particularly relates to a bronchoscope automatic intervention method in a tracheal disease diagnosis and treatment operation, the method comprises the following steps: S1, acquiring data through CT scanning to complete three-dimensional reconstruction of a bronchus model; s2, carrying out data processing on the human bronchial tube and measuring and analyzing a reconstructed model; and S3, realizing an automatic intervention process of the bronchoscope. According to the bronchoscope automatic intervention method in the tracheal disease diagnosis and treatment operation, firstly, data are obtained through CT scanning to complete three-dimensional reconstruction of the bronchus model, then the reconstructed model is measured and analyzed, and finally the automatic intervention process of the bronchoscope is achieved according to the analysis result. The problems that in the bronchoscope interventional diagnosis and treatment process, airway structures of people of different age groups are different, focus positions are uncertain and the like are solved, a corresponding theoretical basis is provided for clinic, instability and uncertainty existing in manual operation are avoided, operation risks are reduced, and operation quality is improved.

The invention discloses a balloon catheter assembly for bronchoscope. The balloon catheter assembly comprises a hairbrush for brush biopsy, an inner catheter used for conveying lavage fluid, medicinefluid and the hairbrush from the external portion to a target bronchus, and an outer catheter which sleeves the inner catheter and is provided with a balloon. The outer catheter is in sealing connection with the inner catheter so that a sealed space can be formed between the inner catheter and the outer catheter, and the balloon can be inflated, wherein the outer catheter is communicated with an air inflation pipe. The inner catheter is provided with a lavage channel, a medicine injection channel and a hairbrush send-in channel, wherein two ends of the lavage channel are penetrating, the lavage channel is used for conveying the lavage fluid, the medicine injection channel is used for conveying the medicine fluid, and the hairbrush send-in channel is used for conveying the hairbrush. An anti-polluting plug used for blockwork is arranged at the outlet end of the hairbrush send-in channel. The balloon catheter assembly is used for bronchoalveolar lavage, medicine injection and hairbrush biopsy of the bronchus, improves the treatment efficiency and reduces the economical burdens of patients.

The invention provides a sample harvester of bronchoalveolar lavage fluid, which comprises a fluid collecting bottle, a first pipeline, a second pipeline, a first buckling cover and a second bucklingcover; there are multiple liquid collecting bottles, and each liquid collecting bottle is detachably and hermetically mounted at the bottom of the first buckling cover through a bottle opening of theliquid collecting bottle; the first pipeline comprises a main pipeline and a plurality of branch pipelines, and the main pipeline is communicated with a plurality of branch pipelines; the first buckling cover is provided with first through holes and a second through hole, the number of the first through holes and the liquid collecting bottles are the same; each branch pipeline is connected with one first through hole, and the second buckling cover is connected with the first buckling cover, and the second buckling cover can move relatively to the first buckling cover; a third through hole is formed in the second buckling cover, and when the second buckling cover and the first buckling cover move relatively, the third through hole can be communicated with each second through hole; one end of the second pipeline is connected with the third through hole. The sample harvester can collect multi-tube bronchoalveolar lavage fluid samples in one time without replacing tubes, the safety is extremely high, and meanwhile the operation is easy and convenient.

The invention relates to an arrangement and method for the in-vitro and in-vivo treatment of bronchial tumors.The aim of the invention to provide an arrangement and a method for operating said arrangement for the in-vitro and in-vivo treatment of bronchial tumors, with said arrangement making the lungs receptive to ultrasound in order to allow the mechanical ultrasound waves to be guided through the healthy lung tissue to the tumor tissue in an optimized manner for the use of FUS therapy, is achieved in that the arrangement comprises a ventilation and respirator system (1) for a lung part to be provided with a gas for respiratory purposes (33), a device for the controlled ventilation and flooding (2) of a lung part to be flooded (34) with a liquid, a therapy system (4), and a central control unit (5), wherein the therapy system (4) consists of at least one therapeutic ultrasonic transducer (40), an imaging-monitoring system (42), and a temperature-monitoring system (41), and the central control unit (5) is connected to the therapeutic ultrasonic transducer (40), the respirator system (1), the device for the controlled ventilation and flooding processes (2), the imaging-monitoring system (42), and the temperature-monitoring system (41) for data-transmission purposes, the respirator system (1) and the device for the controlled ventilation and flooding (2) processes have a gas- and liquid-conducting connection to a lung tube (3), the lung tube (3) can be inserted into a lung containing a tumor (35) in an intratracheal manner, and therapeutic ultrasound doses can be administered by the ultrasonic transducer (40).