221 results about "Bronchial tubes" patented technology

By interposing an adapter between the endotracheal or tracheal tube inserted to a patient and the ventilation and suction systems that are connected to the endotracheal tube, a catheter could be inserted via an input port built into the adapter so as to enable a medical personnel to provide localized treatments in the lungs of a patient without having to disconnect either one of the systems connected to the endotracheal tube. The adapter is configured to have a securing mechanism that allows the medical personnel to secure the medication catheter in place. A one way valve fitted to the apertured arm that forms the input port of the adapter prevents any back flow of fluid from the input port. The catheter is manufactured with calibration markings, most likely equally spaced, and a radiopaque line along its length to enhance the maneuvering and the positioning thereof in the patient so that the distal tip of the catheter could be accurately positioned to the desired location of the patient's tracheal / bronchial tree. As a result, the localized treatment such as the injection of a medicament is accurately provided to the appropriate location where the need is the greatest.

The invention relates to improvements in or relating to medicament delivery devices. In particular, this invention relates to a communications device which may be fitted to an electronic medicament delivery device. The invention may be particularly suitable for use with electronic medicament inhalers such as those used for the treatment of diabetes, or respiratory diseases such as asthma, COPD, cystic fibrosis, and bronchiectasis.

The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3'NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain. Astounding remissions in experimental animals have been demonstrated for the treatment of malignant glioblastoma multiforme, an almost universally fatal neoplasm of the central nervous system.

By interposing an adapter between the endotracheal or tracheal tube inserted to a patient and the ventilation and suction systems that are connected to the endotracheal tube, a catheter could be inserted via an input port built into the adapter so as to enable a medical personnel to provide localized treatments in the lungs of a patient without having to disconnect either one of the systems connected to the endotracheal tube. The adapter is configured to have a securing mechanism that allows the medical personnel to secure the medication catheter in place. A one way valve fitted to the apertured arm that forms the input port of the adapter prevents any back flow of fluid from the input port. The catheter is manufactured with calibration markings, most likely equally spaced, and a radiopaque line along its length to enhance the maneuvering and the positioning thereof in the patient so that the distal tip of the catheter could be accurately positioned to the desired location of the patient's tracheal / bronchial tree. As a result, the localized treatment such as the injection of a medicament is accurately provided to the appropriate location where the need is the greatest.

Devices and methods for treating a diseased tracheobronchial region in a mammal. The device can be a stent which can include a sustained-release material such as a polymer matrix with a treatment agent. The stent can be bioabsorbable and a treatment agent can be incorporated therewith. A treatment method can be delivery of a stent to a tracheobronchial region by a delivery device such as a catheter assembly.

A method of determining potential treatment sites in a diseased lung is disclosed, in which an assessment catheter is introduced into a lung passageway. The catheter has a distal portion comprising an occluding member and a proximal portion configured to operatively mate with an external console. The catheter is used to identify one or more assessment sites within the airways of the lung. At each assessment site, at least one physiological, anatomical or biological characteristic is determined. A characteristic score for each assessment site is calculated based on a predetermined algorithm; and a treatment is determined based on the scores of the assessment sites. The algorithm takes into account several parameters including the disease characteristics as well as the number and proximity of each assessment site to at least one of the diseased regions. The method envisages treatment of emphysema, asthma or bronchopleural leak.

The present invention relates to the use of a compound of formula 3 or a salt thereof for preparing a medicament or a phototherapeutic agent for the treatment of the following diseases, including: acne; AIDS; viral hepatitis; diabetic retinopathy; atypical pneumonia virus infection; coronary Arterial stenosis; carotid artery stenosis; intermittent claudication; Asian (chicken) avian influenza virus infection; cervical dysplasia or various cancers including: blood cancer, cervical cancer, nasopharyngeal cancer, tracheal cancer, laryngeal cancer, bronchial cancer , bronchiolar cancer, bladder cancer, esophagus cancer, stomach cancer, rectal cancer, colon cancer, prostate cancer, hollow organ cancer, bile duct cancer, urinary duct cancer, kidney cancer, uterine cancer, vaginal cancer and other gynecological adnexal cancers. The present invention also relates to methods of treating the above diseases. The present invention further relates to the use of a compound of formula 3 or a salt thereof for the preparation of a photodiagnostic agent for the detection of the above-mentioned diseases and diseases including: atherosclerosis, multiple sclerosis, diabetes, arthritis, rheumatism Arthritis, fungal infection, viral infection, chlamydia infection, bacterial infection, or parasitic infection, HIV infection, hepatitis, herpes simplex, shingles, psoriasis, cardiovascular disease and skin disease. The present invention also relates to methods of detecting the above diseases using photodiagnostic agents. The present invention further relates to a method of cryogenically sterilizing a surgical device or other device, comprising the steps of: providing a compound of formula 3 or a salt thereof on the device; subjecting the device to radiation treatment or sonication. The present invention further relates to a compound of formula 3 or a salt thereof linked or attached to a magnetic element. This compound acts as an MRI enhancer. The present invention also relates to the use of such MRI enhancers for performing MRI scans.

A pharmaceutical combination comprising (a) a combination of two or more bronchodilators; or (b) a combination of at least one bronchodilator in combination with at least one corticosteroid.

The invention discloses a right double-lumen bronchial cannula, which comprises a first branch pipe, a second branch pipe, a first air sac and a second air sac. The right double-lumen bronchial cannula is characterized in that the first branch pipe and the second branch pipe are vertically arranged in a clinging manner; the pipe wall of the first branch pipe is fixedly connected with the pipe wall of the second branch pipe; further, upper-end pipe orifices of the first branch pipe and the second branch pipe are flush with each other; a lower-end pipe orifice of the first branch pipe is an inclined plane, and supports the breath of a left lung; a bent branch pipe is arranged at the lower end of the second branch pipe and is moreover located at the lower-end pipe orifice of the first branch; the central axis of the bent branch pipe and the extension axes of the first branch pipe and the second branch pipe are at an angle; the length of the bent branch pipe is 1.5 to 2 centimeters; a pipe orifice of the bent branch pipe is an inclined plane, and supports the breath of a right lung. The first air sac wraps the outer walls of the first branch pipe and the second branch pipe, and closes a main airway. The second air sac wraps the outer wall of the bent branch pipe at the lower end of the second branch pipe, and is used for closing a right main bronchus. The right double-lumen bronchial cannula has the advantages that the resistance during right single-lung ventilation is relieved; meanwhile, the work load of an anesthesiologist is also reduced.

The present invention relates to a preparation for inhalation use in form of dry powder comprising particles of ambroxol and / or hydrochlorides thereof, and at least a pharmaceutically acceptable excipient and / or dispersant wherein at least 85% of said particles has a geometrical diameter from 3 to 5 [mu]m. The present invention further relates to the methods for preparing such composition and usesthereof. The present invention thanks to the very fine particles of dry powder, as above defined, constitutes a composition for inhalation use with optimum performances which, combined with inhaler action, reaches and acts directly on the bronchi or on the damaged respiratory tract. The local action and the quick absorption of the drug guarantee good features of bioavailability. The decrease in dosing Ambroxol with respect to the other existing oral or injectable formulations allows to reach quickly, locally and safely, the therapeutic target.

The invention relates to a multi-modal endoscope and an endoscopic imaging system. The system combines ultrasonic imaging, optical coherence tomography, fluorescence imaging and electronic endoscopicimaging are combined, has a photographing optical system and photographing elements, the photographing elements are inserted into digestive tracts (esophagus, stomach, duodenum and large intestine) orrespiratory tracts (trachea and bronchus) of an object, and can photograph the digestive tracts and respiratory tracts; and an optical coherence imaging device and a fluorescence imaging device withdifferent imaging principles are arranged, the two devices are in signal connection with an image processing device, and a wavelength division multiplexer is combined and used as a fluorescence imaging system, so that the advantages of various imaging devices can be combined to obtain medical images of tissue and organs, and the system helps to capture more accurate tomograms of the tissue and organs. Compared with the prior art, the multi-modal endoscope and endoscopic imaging system provided by the invention have excellent performance.

The invention relates to a double-lumen bronchial catheter. The double-lumen bronchial catheter aims at overcoming the defects that the outer diameter of a main tube of the double-lumen bronchial catheter is large, intubation difficulty and related intubation injuries are increased, and use of patients with small tracheal glottis or small physique such as children is limited; the inner diameter of a single-lumen tube in the double-lumen bronchial catheter is small, operation of a fiber bronchoscope and a sputum suction tube is not facilitated, and mechanical ventilation resistance is large; and the single-lumen tracheal catheter needs to be replaced for mechanical ventilation after the operation is finished. The other end of a main tube is connected with a connecting tube through a main tube connector; and one end of an auxiliary tube is opened at the midpoint of the c end of a main cuff and the b end of an auxiliary cuff, the other end of the auxiliary tube is connected with an auxiliary tube extension tube, and the other end of the auxiliary tube extension tube is connected with an auxiliary tube extension tube suction connector, a sealing cap, an auxiliary tube extension tube standard ventilation connector and a sealing cap. The catheter can meet the functions of a double-lumen bronchial catheter used at present, including mutual isolation of double lungs, good ventilation of healthy side lungs and rapid collapse of operative side lungs, and ventilation of the healthy side lungs or ventilation of the double lungs and separate suction of the double lungs according to needs; and the catheter has the advantages of large diameter of the single-lumen main tube, small outer diameter of the main tube, reduced intubation difficulty, no need of replacing the tracheal catheter after an operation is finished and the like, and is suitable for people with smaller glottis trachea, such as children.