1272 results about "Kidney" patented technology

A system for perfusing an organ, for example a kidney or a heart. Preservation fluid can be pumped from a transport container to the organ through a cannula or organ adapter. A flow regulator valve can control the rate of flow of the preservation fluid based on renal resistance of the kidney or arterial resistance of the organ. The pump can operate at a rate independent of the arterial resistance.

A transport container for transporting an organ (T), such as a kidney, at hypothermic temperatures. The transport container comprises an inner lid (40) and a canister (38) that can be filled with preservation fluid. The preservation fluid can be pumped from the canister to the organ through a cannula. A flow regulator valve (48) can release the preservation fluid from the fluid path into the transport container at a rate based on at least one organ parameter (such as renal resistance of the kidney), whereas the pump can operate at a rate independent of the at least one organ parameter. The transport container may further comprise a fill port (28) and a vent port in the inner lid, and an organ rest (18).

The invention discloses a renal clear cell carcinoma prognosis prediction method based on multi-mode MRI (Magnetic Resonance Imaging) image and digital pathological omics fusion. The method comprises the following steps: S1, collecting a training data set based on an MR image and a pathological image; s2, feature extraction of MR radiomics; s3, deep learning feature extraction of the pathological image; s4, an MR-pathological feature fusion module; and S5, deploying the network. According to the method, depth features with prognosis information are obtained from two scales of pre-treatment images and post-operation pathology, effective features are extracted by adopting image omics and a convolutional neural network mode according to data characteristics of MR images and pathology images, and depth fusion of the two types of features is completed in a hidden space through a multi-task guiding mode, so that the accuracy of the MR image and the pathology image is improved. A precise prognosis model with multi-scale information is provided, and the method has a relatively strong clinical application prospect and is of great significance for realizing precise immunotherapy and improving prognosis of a patient.

The invention relates to the technical field of artificial intelligence, and discloses a method and a system for dynamically predicting the risk of harm of feed mycotoxin to livestock and poultry. The method comprises the following steps: constructing a metabolic digital twin model based on a multi-organ coupling dynamics mechanism, connecting a gastrointestinal tract, a liver and a kidney through blood flow parameters to form a closed loop topology network, establishing a toxin migration rate equation, and verifying bioavailability; collecting feed toxin concentration and livestock and poultry physiological data in real time; after distributing the initial toxin load, iteratively generating target organ dynamic concentration distribution by adopting a Runge-Kutta method; an organ exposure index is calculated based on an organ specific hazard threshold, key organs are positioned, and low / high risk levels and toxin accumulation paths are output. The method solves the problems that a traditional static model is low in efficiency and poor in organ difference adaptability when being used for dynamically predicting the risk of harm to livestock and poultry caused by feed mycotoxin.

The invention discloses an auxiliary renal puncture device for the nephrology department, and belongs to the technical field of renal puncture, the auxiliary renal puncture device comprises a sickbed, a plurality of supporting legs are fixedly arranged at the bottom of the sickbed, fixing plates are fixedly arranged on the two sides of the sickbed, and second sliding blocks are slidably connected to one sides of the two fixing plates; the breathing frequency and amplitude of a patient are captured in real time through an infrared breathing monitoring module, and displacement data generated by breathing of the kidney are accurately obtained in combination with motion sensing modules such as a lead screw encoder and a driving gear angle encoder. The intelligent control system drives the first stepping motor and the second stepping motor to adjust the position of the portal frame based on six-dimensional force sensor data of the force sensing module, meanwhile, the angle of the puncture needle is adjusted in real time through feedback of a mechanical arm joint encoder, and dynamic compensation of kidney respiratory movement is achieved. According to the mechanism, the puncture deviation caused by breathing can be controlled within the range of + / -0.5 mm, the puncture positioning precision is remarkably improved, and poor sample quality or operation risks caused by breathing movement are avoided.

This application discloses a renal puncture guidance method, system and computer device based on multi-modal fusion, the method comprises: acquiring a medical image sequence of an object to be examined, and performing three-dimensional reconstruction based on the medical image sequence to obtain a three-dimensional reconstruction model; obtaining a slice corresponding to an ultrasonic probe currently in the three-dimensional reconstruction model; displaying a fusion image obtained from a real-time ultrasound image acquired by the ultrasonic probe and the slice in a first region of a puncture guidance interface; acquiring a needle insertion angle of a puncture needle, and displaying a puncture guide line in the fusion image in real time; and displaying the ultrasonic probe model, the puncture needle model and the three-dimensional reconstruction model in real time in a second region of the puncture guidance interface.

The invention discloses a traditional Chinese medicine composition with the effects of benefiting qi, nourishing blood, invigorating the spleen and tonifying the kidney and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: cistanche, ginseng, American ginseng, astragalus membranaceus, medlar, rhizoma polygonati, oyster peptide, angelica sinensis, radix rehmanniae preparata, donkey-hide gelatin, fructus amomi, pericarpium citri reticulatae, hawthorn, folium cortex eucommiae, radix puerariae, liquorice and the like. The preparation method comprises the following steps: respectively crushing the medicinal materials, dissolving the colla corii asini, mixing, adding water, granulating and the like. The composition can be prepared into various dosage forms such as granules, capsules, tablets, oral liquid and the like. Experiments show that the traditional Chinese medicine composition can effectively improve the symptoms of deficiency of qi and blood (increasing erythrocyte count and hemoglobin content), weakness of spleen and stomach (increasing body weight and improving pepsin activity) and kidney deficiency (reducing creatinine and urea nitrogen content and improving SOD activity), and acute toxicity experiments show that the toxicity is slightly reversible under high dosage, and the safety is good under therapeutic dosage. The traditional Chinese medicine composition has potential application value in the aspect of preparing medicines for benefiting qi, nourishing blood, invigorating spleen and tonifying kidney.

The invention relates to the technical field of composite material preparation, in particular to high-mechanical-property granular hydrogel and a preparation method and application thereof.The high-mechanical-property granular hydrogel is prepared by mixing gelatin nano-particles, calcium carbonate nano-particles, ferric oxide nano-particles and a sodium alginate solution under the alkaline condition, then adding gluconic acid-delta-lactone, and conducting stirring, standing and drying to obtain the high-mechanical-property granular hydrogel. Particle hydrogel with high mechanical property is prepared and is simply recorded as Ca-Alg / MCG, and the gel system is endowed with the catheter injectable property, the blood vessel deliverable property and the intravascular hardenability property. The hydrogel can be delivered to small blood vessels of tumors, the mechanical property can be gradually enhanced along with the change of time, and the embolism effect of the granular hydrogel in the blood vessels is further improved. Meanwhile, the magnetic nanoparticles endow the hydrogel with the magnetic-thermal response capability, the temperature can be rapidly increased under an alternating magnetic field, tumor cells are further killed, and the hydrogel shows an excellent embolism effect in a rabbit kidney embolism model and a liver cancer rabbit embolism model.

The invention discloses a traditional Chinese medicine composition for treating autism spectrum disorder and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 4 to 10 parts of cortex cinnamomi, 4 to 10 parts of radix morindae officinalis, 4 to 10 parts of radix polygalae, 4 to 10 parts of rhizoma acori graminei, 5 to 10 parts of radix rehmanniae praeparata, 4 to 10 parts of radix angelicae sinensis, 8 to 20 parts of tortoise shell and 5 to 10 parts of herba dendrobii. From the perspective of overall compatibility, the cinnamon and the morinda officinalis in the composition can warm and tonify kidney yang, the prepared rehmannia root, the tortoise shell and the dendrobe nourish yin and tonify kidney to prevent excessive warm tonification, the angelica sinensis can enrich blood and activate blood and give consideration to spleen and stomach, the polygala tenuifolia can traffic heart and kidney, soothe the nerves and promote intelligence, and the rhizoma acori graminei can reduce phlegm, induce resuscitation and induce resuscitation. The medicines are matched with one another to jointly achieve the effects of tonifying spleen and kidney, replenishing essence and benefiting marrow, and inducing resuscitation and promoting intelligence, and the symptoms of autism are comprehensively improved from the fundamental pathogenesis of spleen-kidney deficiency and by considering pathological changes such as phlegm clogging the heart and the like.

The invention relates to a nephrotic patient health management method and system based on a neural network prediction model, and the method comprises the steps: obtaining the multi-dimensional health data of a target nephrotic patient at each stage, constructing a time sequence feature matrix to extract the change trend of the whole course of disease, and dividing the course of disease into a disease alleviation stage and a disease deterioration stage; analyzing the health data of the two stages to obtain an improvement factor and a deterioration factor; outputting a renal function state prediction result by using a neural network prediction model fusing an attention mechanism and a knowledge graph, and generating an initial health management scheme by combining the result, a preset health management rule base and patient preferences; and optimizing the initial scheme based on the improvement factor, the deterioration factor and a reinforcement learning algorithm to obtain an optimized health management scheme. Complete-cycle closed-loop management of data acquisition, trend analysis, factor identification, prediction and early warning, scheme generation and dynamic optimization of nephropathy patients is realized, and the accuracy and individuation level of nephropathy health management are improved.

The invention relates to the field of modified milk, in particular to pasteurized modified milk with a lead ion emission reduction function and application of the pasteurized modified milk. The pasteurized modified milk provided by the invention contains lactobacillus mucus fermentation B44, wherein the preservation number of the lactobacillus mucus fermentation B44 is CGMCC (China General Microbiological Culture Collection Center) No.17321. Compared with a control sample and other strains, the lactobacillus mucilaginosus B44 in the pasteurized modified milk provided by the invention can remarkably reduce the lead content in intestinal content supernatant, and results of in-vivo experiments of rats show that the lactobacillus mucilaginosus B44 can remarkably reduce the blood lead concentration, the lead content in livers and the lead content in kidneys of drinking objects, so that the lactobacillus mucilaginosus B44 can be used for preparing the pasteurized modified milk. The discharge of lead in excrement can be increased, and liver oxidative damage caused by lead poisoning can be effectively relieved, so that the method can be applied to research on in-vivo emission reduction of lead.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating Parkinson's disease and a preparation method thereof. The traditional Chinese medicine preparation for treating Parkinson's disease comprises the following raw materials in parts by weight: 20-30 parts of bischofia polycarpa, 17-25 parts of eucommia ulmoides, 12-16 parts of artemisia sphaerocephala, 10-15 parts of lycopodium clavatum, 8-13 parts of elm leaves, 7-14 parts of pericarpium citri reticulatae, 5-10 parts of semen cuscutae and 2-7 parts of liquorice. In the formula, monarch, minister, assistant and guide are reasonably matched, the curative effect is exact, and the effects of regulating qi and blood, nourishing liver, warming kidney, activating blood and dissipating blood stasis are achieved. The compound can effectively improve core symptoms of Parkinson's disease and delay disease progression, is expected to be further developed into clinical drugs for treatment of Parkinson's disease, and provides an innovative scheme for traditional Chinese medicine treatment of neurodegenerative diseases.

The systems, devices, and methods described herein relate to catheter devices for therapeutic delivery in renal denervation applications. In some embodiments, the catheter includes a shaft having a first set of electrodes and a second set of electrodes, each of the first set of electrodes and the second set of electrodes including electrodes spaced apart from each other by an inter-electrode spacing and the first set of electrodes and the second set of electrodes spaced apart from each other by an inter-group spacing. In some embodiments, the inter-group spacing may be at least 50% greater than each inter-electrode spacing. In some embodiments, the first set of electrodes or the second set of electrodes may include at least one basket-shaped electrode.

The invention relates to application of 1, 2, 3, 4, 6-O-pentagalloylglucose in preparation of a medicine for resisting cholestatic liver diseases, and belongs to the technical field of medicinal chemistry. The 1, 2, 3, 4, 6-O-pentagalloylglucose provided by the invention can be used for promoting bile acid excretion by reducing WDR6 protein expression. In-vivo and in-vitro experiments prove that the 1, 2, 3, 4, 6-O-pentagalloylglucose can be used for remarkably relieving the symptom of the cholestatic liver disease. In addition, the 1, 2, 3, 4, 6-O-pentagalloylglucose has no obvious toxic or side effect, and has no obvious influence on the liver function and the kidney function. The 1, 2, 3, 4, 6-O-pentagalloylglucose has a wide anti-cholestatic liver disease spectrum, and is suitable for various cholestatic liver diseases, such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and the like.

A computer-implemented method that includes processing a EIT data set of a subject to determine one or more kidney-related conductivity characteristics of the subject, and, determining, based on at least the one or more determined kidney-related conductivity characteristics of the subject, a health state or condition of the at least one kidney of the subject.

The invention discloses a traditional Chinese medicine composition for treating triple-negative breast cancer pulmonary metastasis, which is prepared from the following raw material medicines in parts by weight: 3-5 parts of herba epimedii, 3-5 parts of pseudobulbus cremastrae seu pleiones, 5-15 parts of rhizoma curcumae, 2-8 parts of nidus vespae and 5-15 parts of fructus akebiae. The traditional Chinese medicine composition disclosed by the invention has the effects of removing blood stasis and removing stasis, soothing liver and regulating qi, tonifying kidney and strengthening bone, and removing stasis and detoxifying, and can improve the disease-free survival rate of a metastatic breast cancer patient after operation for 2 years, delay the recurrence and metastasis of the postoperative breast cancer, enhance the immunity of the patient and improve the clinical symptoms of the patient. In addition, the invention further discloses a preparation method and application of the traditional Chinese medicine composition.

The invention relates to the technical field of medical image processing, and particularly discloses an intelligent segmentation system for a kidney tumor in a CT image, and the system comprises an image preprocessing module, an ROI automatic detection module, a kidney tumor segmentation module, a segmentation result post-processing module, a visual interaction module, and a model updating module. The system improves image quality through normalization and filtering, uses a target detection network to position a kidney area, realizes precise tumor segmentation based on an integrated channel attention mechanism and a U-Net network guided by structure priori, optimizes a boundary in combination with a conditional random field, adopts a multi-plane fusion strategy to improve three-dimensional consistency, and calculates tumor volume. The system supports federal learning update, improves the cross-mechanism generalization ability, has the advantages of high segmentation precision, strong boundary reducibility, good structural rationality, strong clinical deployment and the like, and is suitable for kidney tumor auxiliary diagnosis and quantitative analysis.

The present disclosure relates to detecting one or more types of urinary system cancer in a biological sample from a subject. In particular, the present disclosure provides compositions and methods for detecting the presence or absence of one or more types of urinary system cancer (e.g., urothelial carcinoma and / or renal cell carcinoma) in a biological sample from a subject suffering from or suspected of suffering from urinary system cancer.

The invention discloses a traditional Chinese medicine composition for treating aplastic anemia and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises active substances, and the active substances are prepared from, by weight, 6-12 parts of semen cuscutae, 6-12 parts of fructus psoraleae, 6-12 parts of fructus ligustri lucidi, 10-14 parts of radix rehmanniae recen, 4-12 parts of radix scutellariae, 4-12 parts of cortex phellodendri, 10-20 parts of poria cocos, 10-30 parts of radix codonopsis, 6-12 parts of rhizoma atractylodis macrocephalae stir-fried with bran and 2-10 parts of radix glycyrrhizae preparata. The traditional Chinese medicine composition is low in cost, high in AA treatment effect and free of toxic and side effects, and has the effects of tonifying kidney, replenishing essence, detoxifying, descending turbidity and the like; the therapeutic effect on AA can be achieved by adjusting glycolysis of macrophages.

The invention relates to uric acid reducing probiotics obtained by high-throughput screening based on a silkworm model, in particular to a strain SWU-MY69, which is classified and named as Pediococcus pentosaceus, is preserved in China General Microbiological Culture Collection Center (CGMCC), has a preservation number of CGMCC No.31926, and is preserved in September 10, 2024. The pediococcus pentosaceus SWU-MY69 screened through a bombyx mori model has an excellent uric acid reducing effect, the inhibition rates of bacterial suspension, contents and metabolites of the strain on xanthine oxidase in vitro are all 80% or above, and the pediococcus pentosaceus SWU-MY69 also has an excellent inhibition effect on xanthine oxidase in vivo; uric acid in hemolymph is remarkably reduced, excretion of uric acid by intestinal tracts is promoted, and therefore the concentration of uric acid in serum is reduced, and burdens of kidneys and livers are reduced.

The invention discloses a novel HIF-2 alpha proteolysis targeting chimera 1 as well as a preparation method and application thereof, the structural formula 1 of the novel HIF-2 alpha proteolysis targeting chimera 1 is shown in the specification, and the obtained novel HIF-2 alpha proteolysis targeting chimera 1 has good proliferation inhibition activity on kidney cancer 786-O cells. The novel HIF-2alpha protein hydrolysis targeting chimera designed by the invention is novel in structure, few in preparation route process steps, easy to obtain raw materials, suitable for industrial production and good in application value.

The present invention relates to means and methods for modifying renal function in a subject, comprising selecting a patient requiring an increment in renal function; emitting a quantity of ultrasound radiation, enough to provide an increment in renal function, to at least one part of a kidney for a period of time from about 1 hours to about 30 days.

The invention discloses a deep learning-based laparoscopic image kidney tumor segmentation method and system, and relates to the technical field of deep learning, and the method comprises the following steps: constructing a laparoscopic kidney tumor data set RT-AMU, and dividing the RT-AMU data set into a training set and a test set according to a preset proportion; the method comprises the following steps: designing a CNN-Transform hybrid network PEEA-Net of a parallel structure, and taking the CNN-Transform hybrid network PEEA-Net as a kidney tumor initial segmentation model; inputting the training set into a kidney tumor initial segmentation model for model training until the loss function converges, and obtaining an optimized kidney tumor segmentation model; and inputting the test set into the optimized kidney tumor segmentation model to obtain a kidney tumor segmentation result of the laparoscopic image. According to the method and the system, the prediction of finer granularity can be realized when the position of the kidney tumor is accurately positioned, so that a doctor is assisted in treating the kidney cancer in the process of partial renal resection, and the complexity of the doctor in surgical operation is reduced.

The present invention discloses a method for the preparation and application of modified extracellular vesicles specifically targeted to the kidneys. These modified extracellular vesicles are derived from fibroblastic reticular cells in the mesentery tissue and express anti-inflammatory proteins after being modified with anchor peptides. By combining the extracellular vesicles secreted from fibroblastic reticular cells in the mesentery tissue with anchor peptides, the present invention ensures the effective targeting of the exosomes to the kidneys. Additionally, through genetic engineering of fibroblastic reticular cells, the exosomes secreted by these cells can carry the target molecule, anti-inflammatory protein CD5L, achieving precise targeted therapy for the kidneys. This innovative treatment strategy holds promising potential for the treatment of sepsis-associated acute kidney injury, bringing positive impacts to patients' health.

The invention belongs to the technical field of quality control of traditional Chinese medicines, and particularly relates to an establishment method of an HPLC (High Performance Liquid Chromatography) fingerprint spectrum of a kidney-tonifying and liver-nourishing mixture and a multi-index component content determination method. The establishment method of the fingerprint spectrum comprises the following steps: mixing the kidney-tonifying and liver-nourishing mixture and a methanol aqueous solution, carrying out ultrasonic treatment, carrying out HPLC detection on an obtained test solution and a mixed reference substance solution, and introducing an obtained chromatogram into fingerprint spectrum software for treatment, so as to obtain the HPLC fingerprint spectrum of the kidney-tonifying and liver-nourishing mixture. The pretreatment method disclosed by the invention is simple, the characteristic components are completely reserved, and the high performance liquid chromatography is adopted, so that the precision is high, the reproducibility is good, and the stability is good; according to the fingerprint spectrum obtained by the invention, 15 common peaks are determined, the quality of the kidney-tonifying and liver-nourishing mixture can be effectively monitored, and a guarantee is provided for comprehensive and effective control of the quality of the kidney-tonifying and liver-nourishing mixture.

The present invention relates to a compound of Formula 1, a preparation method thereof, a pharmaceutical composition comprising the same as an active ingredient, and a use thereof. The compound of Formula 1 according to the present invention can exhibit cell necrosis and ferroptosis inhibitory efficacy in various cells such as heart, kidney, nerve, retina, liver, or lung cells, and accordingly, can be usefully used for prevention or treatment of cell necrosis or ferroptosis-related diseases.

Compositions and methods for assessing relative macromolecule abundance (for example, RNA expression levels) in a spatially-defined manner across a tissue sample (for example, from brain, lung, liver, kidney, pancreas, and / or heart) are disclosed, specifically providing deep transcriptomic coverage at high-resolution (for example, at approximate 10 μm (single cell) resolution) across multiple locations assessed across the tissue sample.

The invention relates to the technical field of image recognition, in particular to an intraoperative robot image analysis system for renal tumor resection, which is characterized in that ultrasonic images in renal tumor resection are acquired, part of the ultrasonic images form a training set, and the ultrasonic images are equally divided into a plurality of ultrasonic blocks, each ultrasonic block corresponds to one ultrasonic echo signal, energy of the ultrasonic echo signals under different frequency components is obtained, so that the suppression amount of the ultrasonic echo signals is determined to screen out high-suppression-amount ultrasonic blocks, tumor tissue heterogeneity of the high-suppression-amount ultrasonic blocks is determined to obtain up-sampling weights of pixel points in an ultrasonic image, and the up-sampling weights of the pixel points in the ultrasonic image are obtained. Therefore, the training set is trained, and a trained semantic segmentation network model is obtained and is used for segmenting a kidney tumor area in the ultrasonic image. According to the method, the accuracy of kidney tumor area identification is improved through self-adaptive upsampling weight, so that the kidney tumor resection effect is guaranteed.

The present disclosure generally relates to a computer system (100) and a computerized method (300) for predicting a kidney condition for a patient using a machine learning model (200). The method (300) comprises: obtaining (310,330) a current patient input dataset and a historical eGFR input dataset associated with the patient; generating (320) a patient input vector representation (222) using the current patient input dataset and an input linear layer (220); generating (340) an eGFR vector representation (242) using the historical eGFR input dataset and a first input machine learning module (240); concatenating (350) the patient input and eGFR vector representations (222,242) into an output vector representation (260); and generating (360) a prediction output (280) using the output vector representation (260) and an output machine learning module (270), the prediction output (280) comprising a risk assessment of the patient contracting the kidney condition.

The invention belongs to the technical field of kidney puncture, and particularly relates to kidney puncture equipment for living body examination, which comprises a crank assembly, a connecting rod assembly, a variable precision driving assembly, a lifting puncture assembly, a sampling pump, a double-shaft platform and a sliding plate, the sliding plate is arranged on the double-shaft platform, and the crank assembly and the variable precision driving assembly are arranged on the sliding plate. The connecting rod assembly is arranged between the crank assembly and the variable-precision driving assembly, the lifting puncture assembly is arranged in the middle of the sliding plate, and the sampling pump is arranged on the lifting puncture assembly. Under the condition that the precision and the speed of the driving motor are not changed, at the initial stage of descending of the hollow pipe, the relatively high puncture speed is obtained in a precision sacrificing mode, and at the tail stage of descending of the hollow pipe, the relatively high position control precision is obtained in a speed sacrificing mode.