147 results about "Liver functions" patented technology

The invention relates to the technical field of medicines, in particular to a medicinal and edible composition, a preparation method and application of the medicinal and edible composition in relieving acute alcoholic liver injury, and provides the medicinal and edible composition which is composed of ginseng, poria cocos, radix puerariae, fructus lycii, fructus gardeniae, fructus mume and oligo-walnut peptide. The medicinal and edible composition disclosed by the invention is non-toxic, harmless and high in nutritional value, and does not cause severe stimulation and harm to an organism. The health-care wine has a good effect of relieving liver injury, and is especially suitable for people with weakness due to long-term excessive drinking. Meanwhile, animal experiments and clinical verifications prove that the medicinal and edible composition for relieving acute alcoholic liver injury provided by the invention can effectively relieve liver functions, is one of effective methods for relieving symptoms after drinking, relieving inflammation, protecting the liver and improving the life quality, and has a wide application prospect. And a medicinal and edible combination product with good safety and good liver protection effect can be provided clinically. The important social significance is realized on relieving liver inflammation and preventing and treating occurrence and development of liver diseases.

The invention relates to application of 1, 2, 3, 4, 6-O-pentagalloylglucose in preparation of a medicine for resisting cholestatic liver diseases, and belongs to the technical field of medicinal chemistry. The 1, 2, 3, 4, 6-O-pentagalloylglucose provided by the invention can be used for promoting bile acid excretion by reducing WDR6 protein expression. In-vivo and in-vitro experiments prove that the 1, 2, 3, 4, 6-O-pentagalloylglucose can be used for remarkably relieving the symptom of the cholestatic liver disease. In addition, the 1, 2, 3, 4, 6-O-pentagalloylglucose has no obvious toxic or side effect, and has no obvious influence on the liver function and the kidney function. The 1, 2, 3, 4, 6-O-pentagalloylglucose has a wide anti-cholestatic liver disease spectrum, and is suitable for various cholestatic liver diseases, such as primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and the like.

The invention belongs to the technical field of preparation of sea cucumber peptides, relates to preparation of sea cucumber small molecule peptides, and relates to a preparation method of sea cucumber peptides with composite effects of protecting liver and preventing liver cirrhosis, and the sea cucumber peptides with various effects are prepared by using fresh and alive sea cucumbers as raw materials through protease hydrolysis, fishy smell removal, deodorization and other processes. The sea cucumber peptide has the advantages of good solubility, good stability, low viscosity and the like. Compared with the transportation function of amino acid, the sea cucumber active oligopeptide has the characteristics of quick absorption, low consumption and difficulty in saturation, can be added into food, health food, medicine and the like, and has the effects of supplementing nutrition, protecting the liver function, preventing liver cirrhosis, supplementing mineral substances, protein and vitamins and the like.

The invention relates to the technical field of preparation of marine bioactive substances and functional foods, in particular to oyster peptide and application thereof in preparation of products for improving alcoholic liver injury. According to the invention, oyster peptide raw materials rich in natural taurine are adopted, scientific formula design and natural plant alcohol effect dispelling and liver protecting components are adopted, and adverse reactions after drinking, such as hangover, fatigue and alcoholic liver injury, are effectively relieved; according to the oyster peptide tabletted candy formula with the functions of dispelling the effects of alcohol and protecting the liver, provided by the invention, functional components all meet design requirements through detection.

The invention relates to a composition for treating large yellow croaker pyramidoniasis as well as a preparation method and application thereof, and belongs to the technical field of aquaculture. The composition comprises the following components: curcumin, bile acid, beta glucan, bacillus subtilis freeze-dried powder, marine red yeast freeze-dried powder, vitamin C, vitamin E and ethylicin. When the feed additive is added into basal feed to feed large yellow croakers infected with the trypanosomiasis, the death rate of sick fishes can be effectively reduced, the polypide loading capacity is remarkably reduced, and pathological injuries of livers and spleens of the large yellow croakers are relieved. In addition, the composition can also improve the non-specific immunity of the fish body, improve the liver function, enhance the antioxidant capacity of the liver, and improve the lipase activity of the intestinal tract at the same time. Therefore, the composition can be used as a medicine or a feed additive for treating the large yellow croaker pyramidoniasis, has the advantages of small dosage and remarkable effect, and provides a new technical approach for solving the problem that the current large yellow croaker pyramidoniasis lacks an effective prevention and control means.

The invention discloses a targeted slow-release curcumin compound with an auxiliary liver protection function and a preparation method thereof.The preparation method comprises the steps that whey protein isolate is heated under the acidic condition to prepare whey protein isolate fibers, and then the whey protein isolate fibers are compounded with kappa-carrageenan; adjusting the mixed system to be alkaline by adopting a pH migration method, adding a curcumin alkaline solution, fully dissolving the curcumin alkaline solution, and combining the curcumin alkaline solution with the whey protein isolate fiber-kappa-carrageenan composite system; and adjusting the pH value of the system back to be neutral to obtain the high-load amorphous curcumin solution and the solid preparation. The whey fiber and the kappa-carrageenan are self-assembled in the pH circulation process to form a composite carrier, curcumin is converted into an amorphous state from a crystalline state, the solubility of curcumin is remarkably improved, the loading capacity is greatly improved to 70% at most, the heat stability, oxidation resistance and biological accessibility of curcumin are improved, targeted slow release of curcumin can be achieved, and the curcumin-targeted slow release preparation has a good application prospect. The positioning release performance of the curcumin in the intestinal tract part is improved, and the application form of the curcumin in liver protection function products is expanded.

The invention discloses a preparation method and application of a plant composition silymarin and spirulina for relieving alcoholic liver injury, and belongs to the technical field of food processing. The plant composition is composed of spirulina platensis powder and silymarin, can effectively improve the bioavailability of silymarin, realizes slow release of silymarin, has a synergistic effect of relieving liver function and lipid metabolism disorder, oxidative stress and inflammation caused by alcohol, and can be used for treating liver and lipid metabolism disorder. The method can also be applied to preparation of functional food for intervening and preventing alcoholic liver injury.

The invention belongs to the technical field of biological medicines, and discloses application of chrysin in preparation of a medicine for treating alcoholic liver diseases. Wherein chrysin is used for treating the alcoholic liver disease by improving intestinal flora disorder of ALD mice. The research proves that chrysin has a relatively good protective effect on ALD mice from analysis of mouse liver function indexes, blood fat indexes, and richness and diversity of intestinal flora.

The invention belongs to the technical field of microorganisms, and particularly relates to bifidobacterium animalis subsp. Lactis, a product and application of the bifidobacterium animalis subsp. Lactis in liver protection. The preservation number of the bifidobacterium animalis subsp. Lactis BB-35 provided by the invention is CGMCC (China General Microbiological Culture Collection Center) No.27836, and the preservation number of the bifidobacterium animalis subsp. Lactis BB-35 provided by the invention is CGMCC No.27836. The strain can be used for reducing the expression condition of a senescence-related marker p21 in liver cells of mice, and reducing the level of senescence-related secretory phenotype factors, the level of cystatin C and liver function-related biochemical indexes, so that the liver senescence condition of the mice is improved, and the influence on other organs is reduced; in addition, the strain can also improve oxidative stress index malonaldehyde and superoxide dismutase content, reduce inflammatory factor TNF-alpha and IL-6 levels, and provide technical support for preparation of products for preventing, relieving and / or treating liver aging and liver injury.

The invention relates to the technical field of pharmaceutical compositions, and particularly discloses a proteolipid composite supplement with synergistic hangover alleviating and liver protecting functions and a preparation method thereof. The health-care food comprises the following components in percentage by mass: 10-25% of a Pu'er tea extract, 15-30% of glucose syrup, 5-15% of a hovenia acerba extract, 5-15% of a radix puerariae extract, 8-20% of corn peptide, 5-15% of oyster peptide, 3-10% of earthworm peptide, 1-5% of malic acid, 2-8% of multivitamins, 1-5% of an electrolyte compound, 3-10% of prebiotic fibers and 0.5-3% of gamma-aminobutyric acid. The compound vitamins comprise B1, B2, B6, B12, folic acid and vitamin C; the electrolyte compound is a nanoscale electrolyte compound and is an organic chelate containing potassium, magnesium and zinc; the prebiotic fiber is prepared by compounding galactooligosaccharide and resistant dextrin; through compounding design of active peptide components, plant active ingredients and functional factors, the active peptide improves the activity of key enzymes in ethanol metabolism in a targeted manner, and alcohol decomposition is accelerated.

The invention relates to the field of biomedical application of inorganic materials, in particular to application of lanthanum carbonate in preparation of a medicine for treating hepatic encephalopathy. According to the application of lanthanum carbonate in preparation of the medicine for treating hepatic encephalopathy, the medicine comprises lanthanum carbonate and pharmaceutically acceptable auxiliary materials, the lanthanum carbonate comprises any one or more of lanthanum carbonate hydrate and basic lanthanum carbonate, the medicine is ground and then mixed with food to prepare a medicine mixture, and the medicine mixture is prepared into the medicine for treating hepatic encephalopathy. The mass ratio of the lanthanum carbonate in the medicine mixture is 1-10%. According to the application, the blood ammonia is reduced based on the glutaminase, the hepatic encephalopathy is reversed by reducing the blood ammonia and systemic inflammation, and the liver function is recovered by regulating the inflammation, so that the hepatic encephalopathy is favorably cured, a good treatment effect is shown, and a new candidate medicine is provided for clinically treating the hepatic encephalopathy.

The invention belongs to the technical field of functional microorganisms, and provides pediococcus acidilactici MR21 and application thereof. The pediococcus acidilactici MR21 provided by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC) on December 3, 2024, and the preservation number is CGMCC NO. 32896. The pediococcus acidilactici MR21 disclosed by the invention has efficient in-vitro cholesterol removal capacity, excellent safety and remarkable probiotic characteristics, and has the effects of restoring liver functions, reducing liver fat accumulation and regulating expression of fat and cholesterol metabolism related genes by remarkably reducing the content of serum total cholesterol and low-density lipoprotein cholesterol. Therefore, the function of relieving hypercholesterolemia is achieved.

The invention discloses a rumex hanus plant compounded tablet candy capable of dispelling the effects of alcohol and protecting the liver and a preparation method of the rumex hanus plant compounded tablet candy capable of dispelling the effects of alcohol and protecting the liver. Comprising the following raw materials in parts by weight: 15-25 parts of rumex hanus, 10-20 parts of arabinose, 10-15 parts of radix puerariae powder, 8-12 parts of hovenia dulcis thunb powder, 8-10 parts of silybum marianum seed oil microcapsule powder, 5-8 parts of L-glutamine, 3-5 parts of an acid-base regulator and 13-20 parts of auxiliary materials. The invention relates to rumex hanus plant compounded tablet candies capable of dispelling effects of alcohol and protecting liver. According to the invention, rumex hanus is taken as a core raw material, and through component compounding and process optimization, the tabletted candy which takes the rumex hanus active component as a leading component and has multiple target points for dispelling effects of alcohol and protecting liver is prepared, so that triple effects of intestinal barrier protection, alcohol metabolism acceleration and hepatocyte repair are realized. The prepared functional food with rumex hanus as the core is used for preventing drunkenness before drinking, reducing alcohol absorption during drinking, accelerating sobering after drinking and repairing liver and intestine injury caused by alcohol, and is particularly suitable for high-frequency drinking crowds and crowds with vulnerable liver functions.

The invention belongs to the technical field of biological medicine and food, and particularly relates to application of a composition in preparation of a product with a liver protection function, and liver protection comprises liver aging resistance and non-alcoholic liver injury improvement. The composition consists of a silybum marianum extract, a ginger extract and a bitter orange extract. Research finds that the silybum marianum extract, the ginger extract and the bitter orange extract are compounded according to a specific ratio, have a synergistic effect in the aspects of protecting the liver and improving the liver function, and can remarkably improve the mitochondrial function of hepatocytes, resist hepatocyte senescence and improve the non-alcoholic fatty liver disease.

The application provides a preparation method of a soft capsule of Rana spinosa Mato Grosso oil red yeast powder, and belongs to the technical field of health food preparation. Specific weight parts of Rana spinosa freeze-dried powder 50 parts, red yeast powder 20-30 parts, Mato Grosso oil 100 parts and beta-cyclodextrin 10-20 parts are used as raw materials, the Rana spinosa freeze-dried powder is prepared through an optimized freeze-drying process, and the soft capsule is prepared after being mixed uniformly. The application realizes synergistic effect through scientific compounding of raw materials, can comprehensively regulate four indexes of blood lipids, and protects liver function at the same time. The beta-cyclodextrin embedding and soft capsule sealing double protection technology are adopted, so that the shelf life of the product is prolonged to 24 months. The prepared soft capsule has a remarkable effect of reducing blood lipids, is safe and has no side effects, is convenient to take, and is suitable for large-scale industrial production.

The invention relates to a composition based on a natural lignocellulose complex, a source of dietary fiber exhibiting antioxidant and adsorption properties and dihydromyrecitin or quercetin, which ha

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus paracasei BL19 and application thereof to preparation of products with functions of dispelling effects of alcohol and protecting liver. The lactobacillus paracasei BL19 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the lactobacillus paracasei BL19 is CGMCC No.34368. The lactobacillus paracasei BL19 is named as Lactobacillus paracasei BL19. The lactobacillus paracasei BL19 provided by the invention has relatively strong alcohol tolerance, alcohol degradation capability and relatively high activity of promoting alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH); the lactobacillus paracasei BL19 has the advantages that the lactobacillus paracasei BL19 has good anti-alcohol and anti-liver effects and strong capacity of protecting alcoholic injury liver cells, so that the anti-alcohol and anti-liver effects can be comprehensively achieved from multiple dimensions, and in addition, the lactobacillus paracasei BL19 has strong acid resistance and bile salt resistance, also has strong tolerance to simulated gastrointestinal fluid and has important application value in the fields of anti-alcohol and anti-liver products and the like.

The invention discloses a highland barley wine composition with a liver protection effect as well as a preparation method and application of the highland barley wine composition, and relates to the technical field of traditional Chinese medicine compositions. The highland barley wine comprises the following raw materials in parts by weight: 30-600 parts of highland barley wine, 2-10 parts of dandelion, 3-10 parts of dried lalang grass rhizome, 2-15 parts of orange peel, 6-15 parts of cinnamon, 5-15 parts of poria cocos, 2-10 parts of platycodon grandiflorum, 3-10 parts of liquorice, 3-10 parts of kudzu vine root and 3-15 parts of hawthorn. According to the highland barley wine composition, the problem that heat-sensitive liver protection components are easy to degrade due to high temperature in a traditional process is solved through a stepped heating sterilization mode, high-activity components are reserved, and it is ensured that effective components play a synergistic effect in key links such as hepatic cell oxidative stress inhibition and detoxification enzyme activity adjustment; a plurality of traditional Chinese medicine raw material components and the highland barley wine form an anti-oxidation-anti-inflammatory-regeneration-promoting triple synergistic protection network, so that the liver protection function of the highland barley wine is enhanced.

The invention provides a composition containing bile acid and bifidobacterium animalis subsp. Lactis for improving tear stains of dogs and cats. The composition is prepared from the bile acid and the bifidobacterium animalis subsp. Lactis ZYhyy-017, and the composition is prepared from the bile acid, the bifidobacterium animalis subsp. Lactis ZYhyy-017, the bifidobacterium animalis subsp. Lactis ZYhyy-017 and the bifidobacterium animalis subsp. Lactis ZYhyy-017. The bifidobacterium animalis subsp. Lactis ZYhyy-017 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.37292, and the preservation date is January 6, 2026. The bifidobacterium animalis subsp. Lactis ZYhyy-017 is preserved in the China General Microbiological Culture Collection Center (CGMCC). The bile acid is chenodeoxycholic acid (CDCA). The composition regulates and controls a bile acid-porphyrin metabolic pathway in a targeted manner through the synergistic effect of bile acid and bifidobacterium animalis subsp. Lactis ZYhyy-017, porphyrin metabolism in pets is regulated from the source, intestinal and liver axis metabolism and liver functions are optimized, long-acting and safe improvement of tear stains of dogs and cats is achieved, and the composition has a wide application prospect. Meanwhile, the technical blank that bile acid and specific probiotics are synergistically applied to the field of tear stain improvement of dogs and cats is filled up, and the actual requirement for tear stain root improvement in pet feeding is met.

The invention provides a novel probe for monitoring activity of glutamyltranspeptidase as well as a preparation method and application of the novel probe. The preparation method comprises the following steps: (S10) preparing a hemicyanine photoacoustic group containing two hydrophilic sulfonic groups and a hemicyanine molecular solution; (S20) dissolving N-Boc-Glu-OtBu and HATU in an organic solvent, adding DMAP, activating at 0-4 DEG C, adding the hemicyanine molecular solution prepared in the step (S10), and continuously stirring to react; (S30) removing unreacted raw materials and byproducts through washing and drying operations; and (S40) obtaining a target product GGT-probe through an acidic deprotection step and a silica gel column chromatography method, the target product GGT-probe has strong hydrophilicity, can monitor the activity of GGT in a living body level in a non-invasive manner by utilizing the photoacoustic property derived from hemicyanine, and is suitable for being applied to monitoring liver functions and systemic lipid metabolism diseases.

The invention discloses CCL2, a receptor specific binding polypeptide thereof and application of the receptor specific binding polypeptide in prevention and treatment of cholestatic liver diseases, and relates to the technical field of biological medicines. The CCL2 and the receptor specific binding polypeptide thereof, which are screened by a molecular simulation technology, can be specifically bound with a key molecule CCL2 for inducing diseases and a plurality of receptors thereof in a cholestatic liver disease occurrence process, so that liver function indexes are recovered; the traditional Chinese medicine composition can be used for relieving liver pathological injury, including inhibiting bile duct hyperplasia, relieving portal vein inflammatory response and relieving portal vein fibrosis, so that the pathological development process of fibrosis and inflammation caused by the liver injury is blocked.

Provided is a polynucleotide including a nucleotide sequence encoding a vestigial like 4 protein and a cis-regulatory element that controls hepatocyte-specific expression of the sequence encoding a vestigial like 4 protein. Also provided is a viral vector including the polynucleotide, and a cell or organism transfected by the polynucleotide. Also provided is a method of treating steatohepatitis, obesity, hyperglycemia, diabetes, insulin resistance, liver inflammation, or decreasing white adipose tissue in the subject. Also provided is a method of screening a treatment for fatty liver disease or prevention of cirrhosis, comprising feeding a diet high in fat, fructose, and / or cholesterol to a transgenic animal having an hepatocyte-specific vestigial like protein gene disruption, administering the treatment to the transgenic animal, and detecting a difference in liver morphology or liver function between the transgenic animal and a control animal.

The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for treating hyperuricemia. The medicine composition is prepared from the following components in parts by weight: 50 to 100 parts of radix bupleuri, 50 to 100 parts of cortex moutan, 10 to 50 parts of radix codonopsis, 10 to 50 parts of radix clematidis, 10 to 50 parts of rhizoma dioscoreae colletii, 10 to 50 parts of rhizoma smilacis glabrae, 1 to 30 parts of fructus lycii and 1 to 30 parts of liquorice root. The pharmaceutical composition embodies the synergistic effect of traditional Chinese medicines, not only can reduce the content of uric acid and creatinine, but also can reduce the activity of xanthine oxidase, and has an exact effect of treating hyperuricemia. After the pharmaceutical composition is taken for a long time, ALT and AST in biochemical indexes of liver functions do not change obviously, so that the pharmaceutical composition does not cause damage to the liver functions, is safe to the liver and does not have toxic or side effects.

The present invention discloses an application of Lactobacillus plantarum P9 in the preparation of a drug for treating NAFLD, which relates to the field of biotechnology. The Lactobacillus plantarum P9 provided by the present invention can play the role of probiotics, maintain the structure of a healthy intestinal microbial community to protect intestinal homeostasis, relieve non-alcoholic fatty liver disease by protecting the intestinal barrier function and improving the liver's tolerance to intestinal-derived factors through the gut-liver axis, maintain liver function, and ultimately reduce the risk of metabolic disorders. Therefore, Lactobacillus plantarum P9 has the application prospect of preparing a drug for preventing and / or treating non-alcoholic fatty liver disease.

The invention discloses wine with a liver protection function and a preparation method thereof, and relates to the technical field of preparation of health-care wine. The wine comprises the following component raw materials: 20g of fructus lycii, 25g of dried chrysanthemum, 10g of radix puerariae, 10g of lucid ganoderma and 5g of radix angelicae sinensis, and the component raw materials are added into deuterium-depleted water to be subjected to heat preservation extraction at 85 DEG C and filtered to obtain extract liquid 1; extracting filter residues obtained by filtering in 68-72% vol of raw wine at normal temperature, and filtering to obtain extract liquor 2; and reducing the alcohol content of the filtrate 2 by using the filtrate 1 until the alcohol content is reduced to 45% vol, thereby obtaining the finished wine. Through verification, the obtained finished wine has a liver protection effect, can obviously reduce the damage of alcohol to the human liver, enriches wine products, and has an application prospect in the field of health-care wine.

The invention discloses a pharmaceutical composition for preventing or treating subclinical ketosis of dairy cows and application, and belongs to the technical field of animal nutrition and feed science. The invention aims to solve the problem that the prevention and treatment effects are not uniform due to high incidence of ketosis of dairy cows in large-scale pastures. The pharmaceutical composition for preventing or treating the subclinical ketosis of the dairy cow comprises taurine and propylene glycol as active ingredients. The taurine and the propylene glycol are combined, so that the SCK positive rate is effectively reduced, and the energy metabolism, the liver function state, the oxidative stress and the production performance of the SCK dairy cow are improved.

The invention discloses a Chinese herbal medicine feed additive for laying hens, relates to the technical field of feed additives, and is technically characterized in that the feed additive is prepared from the following raw materials in parts by weight: 2-4 parts of scutellaria baicalensis, 4-6 parts of poria cocos, 4-6 parts of codonopsis pilosula, 2-4 parts of cinnamon, 4-8 parts of angelica sinensis, 4-8 parts of honey-fried licorice root and 8-10 parts of gardenia jasminoides. The Chinese herbal medicine feed additive for laying hens provided by the invention effectively improves the production performance and immunity of laying hens. The laying rate of a test group using the additive reaches 91.24%, the average egg weight is increased to 56.72 g, meanwhile, the feed-egg ratio is improved, the soft and broken egg rate is reduced, and it is indicated that the feed utilization efficiency is improved, and the egg quality is improved. In addition, liver function indexes ALT and AST are remarkably reduced, inflammatory indexes IL-1beta and IFN-gamma are reduced, and IL-4 is increased, so that the immunity is enhanced. And the content of unsaturated fatty acid in the eggs is remarkably increased, so that the nutritional value of the eggs is improved. On the whole, the additive has positive influence on health and production performance of laying hens, and has good application potential.

The invention discloses application of a vitex negundo prevention preparation in preparation of a medicine for treating new crown sequelae and a preparation method of the vitex negundo prevention preparation, and belongs to the field of medicines. The negundo chastetree fruit prevention preparation is prepared from eleven raw medicinal materials including negundo chastetree fruit, divaricate saposhnikovia root, notopterygium root, radix angelicae pubescentis, radix bupleuri, radix peucedani, ligusticum wallichii, fructus aurantii, poria cocos, platycodon grandiflorum, liquorice and the like, and has the effects of inducing sweat, dispelling exogenous evils, dispelling wind and clearing damp. The negundo chastetree prevention preparation is an effective formula for treating new crown sequelae, can effectively treat viral myocarditis in the recovery period of new crown patients, and can reduce serum concentration of liver function markers ALT and AST and kidney function markers Cre and BUN, so that liver and kidney functions are effectively protected, inflammatory response of acute respiratory distress syndrome is effectively inhibited, diarrhea is effectively treated, and the curative effect is good. And the traditional Chinese medicine composition has an exact treatment effect on the new crown sequelae.

The present invention relates to a method for producing health-functional milk, comprising the step of selecting healthy dairy cows suitable for raw milk production by analyzing their health status after performing a comprehensive health examination including blood tests on dairy cows, and milking the selected dairy cows while feeding them a feed for constitutional improvement according to the lactation period after calving; wherein the comprehensive health examination includes protein metabolism, energy metabolism, liver function, and mineral metabolism. Accordingly, compared to milk produced by conventional methods, it can exhibit effects such as a fresh taste, reduced off-flavors and fishy tastes, and immune activity.

The present invention relates to the use of Akkermansia muciniphila in the preparation of a pharmaceutical composition for improving alcoholic liver dysfunction. The Akkermansia muciniphila is Akkermansia muciniphila AM06, Akkermansia muciniphila AM02, or a combination of the two; wherein the deposit number of AM06 is CGMCC No. 22793, and the deposit number of AM02 is CGMCC No. 22794. Improving alcoholic liver dysfunction includes preventing and treating alcoholic fatty liver. In this application, liver function indicators (such as ALT and AST) can be improved by reducing triglyceride levels and total cholesterol in the liver and serum, reducing liver fatty degeneration, etc., thereby effectively preventing the occurrence, development, and deterioration of alcoholic fatty liver. It also relates to the use of a composition containing the Akkermansia muciniphila in the preparation or use of a medicine for preventing and treating alcoholic fatty liver.