11 results about "Ethinylestradiol" patented technology

This invention discloses the application of ethinylestradiol and drospirenone in the preparation of drugs for treating post-traumatic stress disorder (PTSD). Ethinylestradiol, as an estrogen receptor agonist, regulates the hypothalamic-pituitary-gonadal axis and is used to treat female hypogonadism, menopausal syndrome, and advanced breast cancer, often in combination with progestins as oral contraceptives. The use of drospirenone and ethinylestradiol tablets (II) after induced abortion can shorten vaginal bleeding time, promote endometrial repair, and reduce the incidence of postoperative complications and repeat miscarriages. This invention has found that ethinylestradiol and drospirenone can reverse the abnormal decrease in hormones and neurosteroids caused by PTSD after spontaneous abortion, particularly the abnormal decrease in serotonin and tetrahydroprogesterone.

The application belongs to the technical field of analytical chemistry, and discloses a qualitative analysis method of ethinyl estradiol and degradation products thereof, which comprises the following steps: determining an accurate mass database and a mass spectrum library of the ethinyl estradiol and degradation products thereof to be detected by using an ultra-high pressure liquid chromatography-quadrupole-electrical field orbitrap high resolution mass spectrometer; detecting the sample by using the ultra-high pressure liquid chromatography-quadrupole-electrical field orbitrap high resolution mass spectrometer; and comparing and analyzing the detection result of the sample with the established accurate mass database and mass spectrum library, so that when the detection result matches the information of the accurate mass database and mass spectrum library, it is determined that the ethinyl estradiol and degradation products thereof to be detected are detected in the sample. The application can realize high-precision qualitative analysis of the sample to be detected by searching for parent ions and daughter ions of the ethinyl estradiol and degradation products thereof by using the ultra-high pressure liquid chromatography-quadrupole-electrical field orbitrap high resolution mass spectrometer, and establishing a high-resolution database.

The application discloses a kind of detection ethinyl estradiol test paper and preparation method thereof, comprising the following steps: (1) preparation Sb2WO6@NiS complex, surface adsorption ethinyl estradiol antibody, i.e. first antibody obtains photo-thermal signal probe;(2) assembly test strip, ethinyl estradiol antigen and second antibody are respectively fixed on detection area and quality control area;(3) after photo-thermal signal probe is mixed with sample liquid to be measured, test strip sample pad end is inserted into the mixed solution and carries out chromatography;(4) detection photo-thermal signal: with near infrared LED illumination detection area and with thermal imaging or temperature measuring equipment acquisition temperature, according to the linear relationship between detection area temperature and sample concentration to be measured quantitative analysis.The application detection mode is flexible, linear range is wide, sensitivity is high, and specificity is good.

The invention discloses a high performance liquid chromatography detection method for ethinylestradiol and nonyl phenol in soil. The method comprises the steps of S1, sample pretreatment, S2, sample extraction, S3, solid phase extraction and purification, S4, high performance liquid chromatography detection and S5, quantitative analysis. The detection method overcomes the defects of a method for synchronously and quantitatively detecting two typical endocrine disruptors in different types of farmland soil in the prior art by aiming at the industrial technical pain points of complex soil matrix, large polarity difference between ethinylestradiol and nonyl phenol and high trace enrichment difficulty; and a stable and reliable technical support is provided for pollution characteristic research, environment fate analysis and ecological risk assessment of ethinylestradiol and nonyl phenol in soil.

The invention discloses a fluorescent platinum cluster capable of targeting an estrogen receptor, and belongs to the crossing field of nanomaterial chemistry and biochemistry. According to the invention, ethinyloestradiol with good biocompatibility is used as a protective ligand, synthesis is carried out through a room temperature volatilization one-pot method, the chemical formula of the metal nanocluster is Pt2Au4C160H184O16, abbreviated as Pt2Au4E8, the space group is P422, a is equal to 13.2176 (5), b is equal to 13.2176 (5), c is equal to 25.7870 (15), alpha is equal to 90 degrees, beta is equal to 90 degrees, gamma is equal to 90 degrees, and V is equal to 4505.1 (4) 3. The metal nanocluster can emit fluorescence under the irradiation of an ultraviolet lamp, and the detection of an estrogen receptor is realized through the interaction force formed between the metal nanocluster and estrogen receptor protein. The method has great potential in the aspects of early diagnosis of tumors, administration or controlled release, intraoperative boundary localization and the like.

The invention relates to the technical field of dairy product detection, in particular to a method for simultaneously detecting three steroid hormone substances in raw milk. The three steroid hormone substances are estradiol, ethinyl estradiol and estrone respectively, and the detection method comprises the following steps: 1) removing protein in raw milk to obtain a sample solution to be detected; (2) carrying out qualitative and quantitative analysis on the three steroid hormone substances in the sample solution to be detected by adopting a high performance liquid chromatography-ultraviolet detection method; wherein the qualitative analysis is based on the retention time of each substance, and the quantitative analysis is based on a standard curvilinear equation to calculate the concentration. According to the detection method, the dependence on expensive instruments and professional operators is remarkably reduced while high sensitivity and accuracy are guaranteed, the cost is low, and the method is particularly suitable for rapid screening of grassroots units and large-batch samples.

Methods for oral contraception comprising administering an oral contraceptive composition comprising 17α-cyanomethyl-17-ß-hydroxyestra-4,9-dien-3-one (dienogest, DNG) and 17α-ethinylestradiol (ethynyl estradiol, EE) are provided. Embodiments of the disclosed methods provide effective contraception with a Pearl Index of less than 0.7 when up to one or two daily oral doses are skipped or delayed.

Methods for oral contraception comprising administering an oral contraceptive composition comprising 17α-cyanomethyl-17-β-hydroxyestra-4,9-dien-3-one (dienogest, DNG) and 17α-ethinylestradiol (ethynyl estradiol, EE) are provided. Embodiments of the disclosed methods provide effective contraception with a Pearl Index of less than 0.7 when up to one or two daily oral doses are skipped or delayed.

The invention provides a desogestrel ethinylestradiol tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the tablet comprises desogestrel, ethinylestradiol, erythritol, a stabilizer, a diluent, a disintegrating agent and an adhesive; the stabilizer is sodium citrate. According to the desogestrel estradiol tablet, the erythritol and the stabilizer sodium citrate are matched, so that the defects of instability and poor solubility of desogestrel can be overcome, the desogestrel estradiol tablet has good stability, and quick release can be realized.

The present application relates to the field of pharmaceutical analysis method, specifically relates to a kind of detection method of related substance in drospirenone ethinylestradiol tablet (II).The method can simultaneously determine drospirenone ethinylestradiol tablet (II) drospirenone, ethinylestradiol and 13 kinds of related substances, method specificity is strong, sensitivity is high, suitable for drospirenone ethinylestradiol tablet (II) Process research, intermediate process control, finished product quality detection and stability research.

The invention provides application of blood nourishing oral liquid combined with drospirenone ethinylestradiol in clinical symptoms and endometrial receptivity after an induced abortion operation, and belongs to the technical field of biological medicine. According to the application of the blood nourishing oral liquid and the drospirenone ethinylestradiol in preparation of the medicine for improving the clinical symptoms after the induced abortion operation, the result of the embodiment shows that compared with a drospirenone ethinylestradiol single administration group, the combined administration group has the advantages that the vaginal bleeding duration is shorter, the vaginal bleeding amount is smaller, the abdominal pain degree is lower, and the clinical symptoms after the induced abortion operation can be improved. The dominant follicle size, the endometrial thickness, the endometrial volume, the type A endometrial rate, the type III endometrial and the ratio of the endometrial-muscular layer binding band are all higher than those of a control group, and the aneurysm hemodynamic indexes are all lower than those of a single administration group. Therefore, the blood-nourishing oral liquid combined with drospirenone ethinylestradiol can effectively improve postoperative clinical symptoms of patients, promote follicle development and improve endometrial receptivity.