5 results about "Ethinylestradiol" patented technology

This invention discloses the application of ethinylestradiol and drospirenone in the preparation of drugs for treating post-traumatic stress disorder (PTSD). Ethinylestradiol, as an estrogen receptor agonist, regulates the hypothalamic-pituitary-gonadal axis and is used to treat female hypogonadism, menopausal syndrome, and advanced breast cancer, often in combination with progestins as oral contraceptives. The use of drospirenone and ethinylestradiol tablets (II) after induced abortion can shorten vaginal bleeding time, promote endometrial repair, and reduce the incidence of postoperative complications and repeat miscarriages. This invention has found that ethinylestradiol and drospirenone can reverse the abnormal decrease in hormones and neurosteroids caused by PTSD after spontaneous abortion, particularly the abnormal decrease in serotonin and tetrahydroprogesterone.

The invention discloses a high performance liquid chromatography detection method for ethinylestradiol and nonyl phenol in soil. The method comprises the steps of S1, sample pretreatment, S2, sample extraction, S3, solid phase extraction and purification, S4, high performance liquid chromatography detection and S5, quantitative analysis. The detection method overcomes the defects of a method for synchronously and quantitatively detecting two typical endocrine disruptors in different types of farmland soil in the prior art by aiming at the industrial technical pain points of complex soil matrix, large polarity difference between ethinylestradiol and nonyl phenol and high trace enrichment difficulty; and a stable and reliable technical support is provided for pollution characteristic research, environment fate analysis and ecological risk assessment of ethinylestradiol and nonyl phenol in soil.

The invention relates to the technical field of dairy product detection, in particular to a method for simultaneously detecting three steroid hormone substances in raw milk. The three steroid hormone substances are estradiol, ethinyl estradiol and estrone respectively, and the detection method comprises the following steps: 1) removing protein in raw milk to obtain a sample solution to be detected; (2) carrying out qualitative and quantitative analysis on the three steroid hormone substances in the sample solution to be detected by adopting a high performance liquid chromatography-ultraviolet detection method; wherein the qualitative analysis is based on the retention time of each substance, and the quantitative analysis is based on a standard curvilinear equation to calculate the concentration. According to the detection method, the dependence on expensive instruments and professional operators is remarkably reduced while high sensitivity and accuracy are guaranteed, the cost is low, and the method is particularly suitable for rapid screening of grassroots units and large-batch samples.

The invention provides a desogestrel ethinylestradiol tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the tablet comprises desogestrel, ethinylestradiol, erythritol, a stabilizer, a diluent, a disintegrating agent and an adhesive; the stabilizer is sodium citrate. According to the desogestrel estradiol tablet, the erythritol and the stabilizer sodium citrate are matched, so that the defects of instability and poor solubility of desogestrel can be overcome, the desogestrel estradiol tablet has good stability, and quick release can be realized.

The present application relates to the field of pharmaceutical analysis method, specifically relates to a kind of detection method of related substance in drospirenone ethinylestradiol tablet (II).The method can simultaneously determine drospirenone ethinylestradiol tablet (II) drospirenone, ethinylestradiol and 13 kinds of related substances, method specificity is strong, sensitivity is high, suitable for drospirenone ethinylestradiol tablet (II) Process research, intermediate process control, finished product quality detection and stability research.