28 results about "Suppository" patented technology

The utility model relates to an intravascular antithrombotic magnetic control device which comprises an intravascular device and an external magnetic control device, the intravascular device comprises a medicine carrying assembly, a conveying catheter and a release control module, and the medicine carrying assembly and the release control module are respectively arranged in the conveying catheter; the external magnetic control device is used for fixing one end of the conveying catheter and is in communication connection with the release control module. The utility model has the benefits that the structure is simple, the design is reasonable, the release of suppository particles is accurately controlled through an external magnetic field, the minimally invasive treatment of a patient is realized, and safety and reliability are realized.

The invention relates to an integrated nursing device for eliminating thrombus in a PICC (Peripherally Inserted Central Catheter) by ultrasonic waves, which belongs to the technical field of medical instruments and comprises a handheld host and a disposable treatment head. A venturi negative pressure generating unit and a flushing fluid power unit are integrated in the handheld host. The disposable treatment head comprises a multi-section flexible connection structure capable of self-adapting to bending of the catheter, a miniature ultrasonic suppository breaking unit capable of achieving cross interference focusing based on a single crystal wafer and a reflection cavity, and a multi-layer coaxial cavity structure capable of achieving synchronous suction and flushing. When the device works, ultrasonic energy directly acts on thrombus in a catheter to efficiently crush the thrombus, meanwhile, fragments are removed in time through negative pressure generated by the Venturi effect, and visual state indication is provided through the mechanical feedback unit. The problems that a traditional method is low in efficiency, complex in operation and asynchronous in fragment removal are solved, and safe, efficient and convenient integrated catheter thrombus removal is achieved.

The utility model belongs to the technical field of gynecology medical instruments, and provides a woman packing adsorption suppository with a telescopic function, which comprises a pushing unit and a packing unit, the pushing unit comprises a pushing tube, the other end of the pushing tube is provided with a movable opening, and the packing unit is arranged in the movable opening. The other end of the pushing pipe is movably connected with a pushing rod through a movable opening, one end of the pushing rod is fixedly connected with a pushing plate, and a through opening is formed in one end of the pushing plate in a penetrating mode. The filling unit comprises an adsorption bolt body movably connected to the interior of the pushing pipe, an adjusting bolt is fixedly connected to one end of the adsorption bolt body, a limiting bolt is fixedly connected to one end of the adjusting bolt, a telescopic adsorption bolt is movably connected to the outer side of the adjusting bolt, and a sliding sleeve is fixedly connected to one end of the telescopic adsorption bolt; when a person walks and moves and slides down, the woman filling adsorption plug can be located at the optimal adsorption position, and therefore the adsorption effect of the woman filling adsorption plug is guaranteed.

1. Name of the product in this design: Packaging Box (Double-Zolpidem Suppository). 2. Intended use of this design: for pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key features: the front view.

This utility model discloses a protective silicone sleeve adapted for use with glycerin suppositories, comprising a spindle-shaped silicone body. The tail end of the silicone body has an insertion channel extending along its axis towards the head end, for inserting the head end of the suppository. The head end of the silicone body has a through-hole communicating with the insertion channel. An elastic antibacterial sleeve is fitted onto the outer wall of the silicone body near the tail end. The elastic antibacterial sleeve is formed by continuously rolling from the first end to the second end through an elastic tubular sheath, creating a ring-shaped self-rolling state. In its flattened state, the elastic antibacterial sleeve is longer than the silicone body. The silicone body is nestled into the front end of the opened suppository for alternative contact. After administration, the silicone body is removed, and the elastic antibacterial sleeve is flattened towards the front end to wrap around the silicone body. This significantly reduces the possibility of anal injury, greatly improves the patient's sense of security and comfort during treatment, and effectively shields and isolates the silicone body from contaminants after use.

Disclosed are suppositories and methods of use thereof for lubricating an internal surface of a body cavity. A suppository may be composed of a shell defining an internal volume and a lubricant at least partially occupying the internal volume. The shell may be prone to degrade in that a rate of degradation thereof may increase when the suppository is in a certain condition, such as being exposed to an external environment or being positioned inside the body cavity. Once sufficient degradation of the shell has occurred while the suppository is inside the body cavity, the lubricant may be released and applied onto an internal surface of the body cavity. Medical procedures or pleasurable activities related to the body cavity may then be performed which rely upon or are aided in part by the lubrication of the body cavity's internal surface.

This invention discloses a composition and its preparation method for treating human papillomavirus (HPV) and cervical intraepithelial neoplasia (CIN), belonging to the field of traditional Chinese medicine technology. The formula consists of 6-15 parts of American cockroach, 5-11 parts of hawthorn, 5-11 parts of chicory, 3-9 parts of *Scutellaria baicalensis*, 8-20 parts of *Sophora flavescens*, and 6-15 parts of *Cnidium monnieri*, and also contains 0.01-1 parts by weight of toad venom. The dosage form is one or more of the following: external gel, rinse, foam, suppository, and film preparation. It has high safety and is suitable for HPV infection and CIN changes, solving the problem of poor efficacy in existing treatments.

The invention relates to an antithrombotic catheter. The antithrombotic catheter comprises a hydrogel coating containing a thrombolytic agent. The thrombolytic agent may be a lyophilized tissue plasminogen activator. The catheter has an inner lumen surface and an outer lumen surface, and a hydrogel coating is disposed on the inner lumen surface and / or the outer lumen surface. The hydrogel coating may have a thickness in the range of about 50 nm to about 150 nm. The hydrogel coating may contain from about 0.1 wt% to about 1 wt% of a tissue plasminogen activator. The hydrogel coating may be made from a synthetic hydrogel or a natural hydrogel. Presently preferred synthetic hydrogels include polyacrylamide based hydrogels. Presently preferred natural hydrogels include hyaluronic acid based hydrogels. The hydrogel coating reacts in the presence of a physiological liquid to absorb water and elute the solvating suppository. The hydrogel controls elution of the thrombolytic agent. Examples of physiological fluids include interstitial fluids and blood.

The invention discloses an emulsion type suppository practical for vaginal administration, and relates to the technical field of pharmaceutical preparations, the suppository is a solid at room temperature, and can be converted into a cream type preparation in situ under vaginal temperature and wetting conditions; the suppository is composed of active and pharmaceutically acceptable auxiliary materials, the auxiliary materials comprise structural lipid, an emulsifier, a gel matrix and a pH regulator, and a suppository body is softened at body temperature and mixed with body fluid to form a cream mixture easy to coat on the mucous membrane surface in situ. The transformation process avoids greasy feeling and local discomfort possibly brought by a traditional greasy suppository, and also eliminates the trouble that the prefabricated cream needs to be matched with a special administration device, so that the local medication experience of a patient is improved while the administration convenience is ensured. Besides, through reasonable selection of auxiliary materials, the cream formed through conversion can provide proper adhesion, and the retention time of the medicine at the action part can be prolonged.

This invention discloses a suppository for treating endometritis in cattle and sheep, its preparation method, and its application, belonging to the field of veterinary drug preparation technology. The suppository uses Salvia miltiorrhiza, Coptis chinensis, Forsythia suspensa, Carthamus tinctorius, Borneol, and Astragalus membranaceus as active ingredients. Coptis chinensis and Forsythia suspensa clear damp-heat, while Salvia miltiorrhiza and Carthamus tinctorius unblock stagnation. Astragalus membranaceus replenishes postpartum qi deficiency, promotes blood circulation, enhances blood circulation, strengthens the body's resistance to pathogens, prevents inflammation recurrence, harmonizes the cold properties of other herbs, and reduces side effects. Borneol, with its pungent and penetrating properties, guides the medicine directly to the lesion, promotes mucosal repair, increases mucosal permeability, relieves pain and itching, and synergistically provides anti-inflammatory and analgesic effects, improving the user experience. It is suitable for local suppository administration, aligning with the principles of traditional Chinese veterinary medicine for endometritis, simultaneously exerting the effects of clearing heat and dampness, promoting blood circulation and removing blood stasis, and tonifying qi and strengthening the body, addressing both the symptoms and the root cause. By adding a matrix and excipients and combining vaginal administration to treat endometritis in cattle and sheep, the local drug concentration is concentrated for rapid onset of action, achieving a balance between effectiveness, convenience, and safety.

This document discloses compositions comprising one or more polyglutamic acid compounds. These compositions are used to treat, improve, prevent, or alleviate symptoms of vaginal dryness and menopausal symptoms. This document also describes compositions for treating, improving, preventing, or alleviating other dry skin symptoms on the body, extremities, hands, feet, neck, or face in subjects of all ages and sexes. This document also describes topical and suppository formulations of the compositions.

The invention provides a double-layer anus suppository for intestinal flora transplantation and a preparation method thereof, and relates to the technical field of biological medicine, the double-layer anus suppository comprises an outer layer and an inner layer, the outer layer is prepared from the following components in percentage by weight: 88-94% of low-melting-point semi-synthetic fatty glyceride, 0.5-3% of temperature-sensitive gel, 3-8% of polyethylene glycol, 1-4% of lubricating additive and 0.5-2% of surfactant, and the inner layer is prepared from the following components in percentage by weight; the inner layer is prepared from the following components in percentage by weight: 80-90% of high-melting-point semi-synthetic fatty glyceride, 1-25% of intestinal flora freeze-dried powder, 2-6% of a freeze-drying protective agent, 5-12% of polyethylene glycol and 0.5-3% of an emulsifier; by the adoption of the double-layer design, after entering the rectum, the double-layer enteric-coated suppository can be rapidly softened and responded, discomfort is effectively reduced, displacement is rapidly started by means of intestinal tract lubrication, meanwhile, the rectum environment is isolated in the initial stage, the inner layer core is protected, and it is ensured that active ingredients are released in a large number after being accurately delivered.

The utility model provides a kind of for colorectal anus medicine feeder, belong to medical appliance technical field, including medicine feeder, the end portion of medicine feeder is connected with connecting cap by screw thread, the outer end of connecting cap is fixedly connected with medicine tube, a group of medicine holes is evenly set on the medicine tube, the outer end of medicine tube is connected with connecting head by internal thread, the outer end of connecting head is fixedly connected with connecting plate, the connecting plate is fixedly connected with plug elastic clamp, the medicine feeder is equipped with moving block, the outer circumferential side wall of moving block is fixedly connected with piston ring.The utility model is equipped with connecting cap, medicine tube, medicine hole, connecting head, connecting plate, plug elastic clamp and push medicine mechanism, realizes both can deliver hydraulic medicine to the patient's affected area and can deliver suppository medicine to the patient's affected area, significantly improve the flexibility of medicine feeder, can deliver suppository medicine to position, guarantee the full play of drug efficacy, solve the problem of inconvenient delivery suppository medicine in prior art.

The invention discloses a compound infantile antipyretic double-layer suppository and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the compound infantile antipyretic double-layer suppository is composed of a quick release layer and a slow release layer, the quick release layer comprises 150-180g / 1000 paracetamol, 4-6g / 1000 artificial bezoar, 10-20g / 1000 sustained release layer, 10-20g / 1000 sustained release layer, 10-20g / 1000 sustained release layer and 10-20g / 1000 sustained release layer. The sustained release layer comprises 40-60g / 1000 pieces of rhizoma et radix baphicacanthis cusiae extract powder and 40-60g / 1000 pieces of acetaminophen, biphase drug release is achieved through the hydrophilic and hydrophobic difference of a bilayer matrix, the onset time can be shortened, the continuous fever abatement time can be prolonged, and the symptom improvement rate of a patient is greatly increased.

The invention provides a novel application of an antibacterial peptide Ly (PEG)-1 reported at an earlier stage in vaginitis, belongs to the technical field of biomedical polypeptides, and particularly relates to preparation of the antibacterial peptide Ly (PEG)-1, an effect of the antibacterial peptide Ly (PEG)-1 on main vaginal pathogenic bacteria and symbiotic bacteria and an application of the antibacterial peptide Ly (PEG)-1 in prevention or treatment of bacterial vaginitis. The antibacterial peptide Ly (PEG)-1 provided by the invention is short in sequence, low in production cost, capable of strongly inhibiting main pathogenic bacteria of vagina, small in influence on main normal bacteria of the main pathogenic bacteria, capable of effectively treating vagina inflammation and maintaining the steady state of vaginal flora, high in stability and good in antibacterial effect. Vagina inflammatory diseases caused by infection of various pathogenic bacteria can be prevented and treated through various administration modes such as spraying, instillation, suppositories and effervescent tablets or systemic administration modes such as intraperitoneal injection and the like.

1. Name of the designed product: packing box (hemorrhoid suppository). 2. Use of the designed product: for product packing. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: front view.

This invention provides a probiotic composition for the prevention and / or treatment of vaginal infections and related diseases, and its use therein. The probiotic composition comprises *Lactobacillus plantarum* and *Lactobacillus fermentum*, wherein the gene sequence of the molecular marker of *Lactobacillus plantarum* has the nucleotide sequence shown in SEQ ID NO: 1, or the nucleotide sequence thereof is shown in SEQ ID NO: 1; and the gene sequence of the molecular marker of *Lactobacillus fermentum* has the nucleotide sequence shown in SEQ ID NO: 2, or the nucleotide sequence thereof is shown in SEQ ID NO: 2. The probiotic composition of this invention achieves better efficacy in treating vaginal infections, especially vulvovaginal candidiasis, compared to single strains therein and existing positive control drugs such as metronidazole suppositories.

The invention belongs to the technical field of polypeptide preparation, and provides collagen-based antibacterial peptide and a preparation method thereof. Connecting carboxyl of the collagen peptide with amino acid, dipeptide or tripeptide; the amino acid, the dipeptide or the tripeptide is composed of lysine and arginine. The antibacterial peptide can be used as an effective component of an antibacterial drug and can be prepared into an external application patch, a suppository, a surgical implant material and the like for preventing bacterial and fungal infection. The antibacterial peptide can also be used as a feed additive or a veterinary drug to be applied to animals. The raw materials are wide in source, the synthesis method is simple, and the cost is low; the prepared antibacterial peptide is good in salt tolerance, has an antibacterial effect under a wide pH range, and is good in biological safety; the antibacterial peptide has a good inhibition effect on gram-negative and gram-positive bacteria, especially has good biological activity on common vaginal malignant bacteria, and has a wide application prospect.

The present invention provides a gel, suppositories, and a method for producing the gel that can compensate for the deficiency of naturally released lactic acid and hydrogen peroxide, lower vaginal pH, and improve the health of the vaginal microbiome. [Solution] The gel contains 50-150 mM concentrated lactic acid and 0.5-10 mM concentrated hydrogen peroxide, and the 50-150 mM concentrated lactic acid and the 0.5-10 mM concentrated hydrogen peroxide are combined.

The invention discloses an anorectal medicine feeding device, and belongs to the technical field of medical instruments. The anal suppository solves the problem that the suppository cannot accurately act on an affected part when the suppository is directly stuffed into the anus. The device comprises a medicine inlet pipe capable of being inserted into the anus, the medicine inlet pipe is connected with a medicine feeding head, the medicine feeding head comprises a supporting cylinder and an elastic layer, a cavity in the supporting cylinder forms a fifth cavity, and a gap between the supporting cylinder and the elastic layer forms a sixth cavity; a first medicine feeding hole is formed in the supporting cylinder, a plurality of second medicine feeding holes are formed in the elastic layer, a first-stage dispersing structure is arranged between the first medicine feeding hole and the second medicine feeding holes, and a second-stage dispersing structure is arranged in each second medicine feeding hole; the medicine inlet pipe is connected with a first driving mechanism; the medicine inlet pipe is further connected with a second driving mechanism capable of enabling the medicine in the second dispersing structure to be separated from the second dispersing structure. By means of the device, medicine can be evenly sprayed to the affected part in the anorectum, the effect of precise medicine application is achieved, and the medicine application effect can be effectively improved.

1. The name of the design product: hemorrhoid suppository. 2. The use of the design product: the design product is applied to the suppository medicine for treating hemorrhoids, and directly acts on the anal rectal mucosa through rectal administration. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: design 1 front view. 5. Design 1 is designated as the basic design. 6. Other conditions that need to be explained: when in use, the suppository part of the head enters the anal rectum and is separated from the push part of the tail.

This invention provides a probiotic composition for the prevention and / or treatment of vaginal infections and related diseases, and its use therein. The probiotic composition comprises *Lactobacillus curvatureii*, *Lactobacillus jenny*, *Lactobacillus gasseri*, *Lactobacillus plantarum*, and *Lactobacillus fermentum*. Experiments have demonstrated that the probiotic composition of this invention achieves better efficacy in treating vaginal infections, especially VVC, compared to single-strain probiotics and positive control drugs such as metronidazole suppositories and diclofenac sodium.

The invention provides an umbilical region application suppository for reducing uric acid and a preparation method thereof, and relates to the technical field of medicines.The umbilical region application suppository for reducing uric acid comprises a suppository body, and the suppository body comprises an emulsified oil phase, an emulsified water phase, a surfactant and a traditional Chinese medicine composition, the traditional Chinese medicine composition comprises cortex phellodendri, radix sophorae flavescentis, rheum officinale, oriental wormwood, lysimachia christinae hance, semen plantaginis, rhizoma alismatis, poria cocos, astragalus membranaceus, ginseng, cassia twig and fructus cnidii. Uric acid reduction treatment is achieved in an umbilical region application mode, gastrointestinal tract stimulation and liver metabolism burden caused by oral medicine are avoided, meanwhile, the use process of a patient is simplified, and treatment compliance is improved. The design of the suppository body is combined with an emulsification technology, so that the stability and the release consistency of the medicine are ensured, and the compound compatibility of the traditional Chinese medicine composition provides a comprehensive regulation effect on the pathological link of the hyperuricemia. In addition, the penetration efficiency of the umbilical skin barrier is high, the synergistic effect of drug sustained release and whole body regulation can be achieved, and a new way is provided for uric acid reduction treatment.

The utility model discloses an anorectal suppository containing device, and particularly relates to the technical field of medical instruments, the anorectal suppository containing device comprises a medicine outlet assembly, the bottom of the medicine outlet assembly is fixedly connected with a movable assembly, and the bottom of the movable assembly is provided with an extrusion assembly; the extrusion assembly comprises a rotating hand disc, a connecting groove is formed in the top surface of the rotating hand disc, a threaded opening is formed in the inner wall of the connecting groove, a turntable bearing is fixedly connected to the center of the top of the rotating hand disc, a plurality of reset springs are fixedly connected to the top of the turntable bearing, and extrusion blocks are fixedly connected to the tops of the reset springs. A plurality of annular connecting plates are fixedly connected to the bottom of the extrusion block, a plurality of cross-shaped sliding blocks are fixedly connected to the outer sides of the annular connecting plates, fixing plates are fixedly connected to the ends, away from the annular connecting plates, of the cross-shaped sliding blocks, and pull columns are fixedly connected to the center positions of the sides, away from the cross-shaped sliding blocks, of the fixing plates; the center of each pull column is fixedly connected with a pressing block. And the problem of pain caused by dryness of the anus is solved.

The sanitary glycerine enema capable of absorbing liquid comprises an installation support and a glycerine enema suppository main body, the bottom of the glycerine enema suppository main body is installed on the installation support, and a hollow pipe is connected to the bottom of the installation support; the surface of the hollow pipe is sleeved with the expansion cotton strip, and the expansion cotton strip is used for absorbing liquid; and one end of the pull rope is installed in the hollow pipe, the other end of the pull rope extends to the outer portion of the end, away from the installation support, of the hollow pipe, and the pull rope is used for pulling the installation support. After the glycerine enema suppository main body is plugged into the rectum of a patient, the expansion cotton sliver can absorb flowing-out liquid, so that the flowing-out liquid is prevented from staining clothes, meanwhile, the expansion cotton sliver expands after absorbing the liquid, the anus of the patient is blocked, and the glycerine enema suppository main body is further prevented from automatically sliding out of the rectum; therefore, a patient can more easily insist on the effect of the glycerine enema suppository main body.

Disclosed is a bacteriostatic composition, a method for preparing the same, and use thereof. The bacteriostatic composition of the present invention comprises one or more fatty acids and / or salts thereof, one or more dibasic acids and / or salts thereof, one or more aromatic alcohols, and one or more aromatic acids and / or salts thereof. The bacteriostatic composition can be prepared as an aqueous solution, a water-soluble gel, a foam, a spray, an ointment, a powder, a film, a capsule, a suppository, or a tablet, and can be used to inhibit harmful microorganisms, particularly abnormal flora in the vagina.

The vagina inflammation packing bolt comprises a baffle, the baffle is fixedly connected to the outer side of the front end of a mounting shell, a plurality of sets of annularly-distributed inserting holes are formed in the middle of the baffle, inserting rods penetrate through the inner sides of the inserting holes and are in sliding connection with the inner sides of the inserting holes, the inserting rods are fixedly connected to the outer side of the front wall of a lubricating ring and are annularly distributed, and the lubricating ring is fixedly connected to the front end of the inner side of a protective shell. A piston hole is formed in the middle of the rear wall of the mounting shell, a push rod penetrates through the inner side of the piston hole and is in sliding connection with the inner side of the piston hole, and a pull plate is fixedly connected to the front end of the push rod. According to the vagina inflammation tampon, when the tampon needs to be used, a baffle ring is pulled out of an insertion rod, then the insertion rod is separated from an insertion hole, accordingly, a protection shell can be taken down from the outer side of a mounting shell, a lubricating ring makes contact with the outer wall of the mounting shell in the process of pulling out the protection shell, lubricating liquid is smeared on the surface of the mounting shell, resistance in the tampon insertion process is reduced, and the service life of the tampon is prolonged. Therefore, the comfort of the filling bolt is improved.