3 results about "Thrombolytic Agent" patented technology

Provided is a thrombolytic agent for ‘intravascular thrombus’, and more particularly, to a thrombolytic agent having a thrombo-recognition domain and a thrombolytic domain. It also relates to a polypeptide for thrombolysis of an intravascular thrombus, a gene for that polypeptide, and a pharmaceutical composition containing the same. The polypeptide that recognizes ‘intravascular thrombus’ and dissolves thrombus of the present invention is characterized in that it consists of a thrombolytic domain comprising the amino acid sequence set forth in SEQ ID NO: 1 or SEQ ID NO: 2 and a thrombo-recognition domain comprising the amino acid sequence set forth in SEQ ID NO: 3 or SEQ ID NO: 4. According to the present invention, the polypeptide for dissolving thrombus by recognizing ‘intravascular thrombus’ dissolves thrombus in the blood of a mammal without serious bleeding side effects has a preventive and therapeutic effect on thrombosis, thus preventing thrombosis and related diseases.

This invention discloses a sonodynamic synergistic thrombolysis system and its application. The system includes a tissue plasminogen activator variant, a sonosensitive agent, and an ultrasound source. The tissue plasminogen activator variant is an intravenously administered formulation, the sonosensitive agent is an intravenously infused formulation, and the ultrasound source is used to emit ultrasound during sonosensitive agent administration to activate the agent. This invention significantly improves thrombolysis efficiency and reduces thrombolytic agent dosage and bleeding risk through the dual synergistic effect of TNK-tPA enzymatic hydrolysis and sonodynamic chemical oxidation. The system can significantly improve vascular recanalization rate and blood flow velocity recovery rate, and has high biocompatibility. This invention is applicable to thrombolytic treatment of various thrombotic diseases and has the advantages of simple operation, strong targeting, and wide application range.

This invention provides a thrombolysis catheter structure and an interventional device for thrombosis treatment, relating to thrombosis treatment medical devices. The device includes a thrombolysis catheter and a thrombolysis head. The proximal end of the thrombolysis catheter is connected to an ultrasonic transducer to receive vibrational energy. The thrombolysis catheter also has a first inlet for introducing thrombolytic agents. The thrombolysis head is fixedly connected to the distal end of the thrombolysis catheter, and the diameter of the thrombolysis head is larger than the diameter of the thrombolysis catheter. The thrombolysis head has a drug chamber that communicates with the distal end of the thrombolysis catheter. The thrombolysis head also has a spray hole communicating with the drug chamber, facing distally. This invention enables simultaneous ultrasonic thrombolysis and drug thrombolysis, allowing mechanical thrombolysis and drug thrombolysis to act simultaneously on the same area of ​​the thrombus, significantly improving thrombosis treatment efficiency. Furthermore, since thrombolysis and thrombolysis are performed concurrently, there is no need to change surgical instruments multiple times to perform the thrombolysis and thrombolysis processes separately, which helps to shorten the operation time.