95 results about "Acute ischemic stroke" patented technology

Devices, methods, and systems facilitate and enable treatment of ischemic stroke. More specifically, a tethered basket-like system operates in conjunction with a microcatheter system, to provide arterial support and capture emboli.

Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.

A method for treating acute ischemic stroke in a human comprises administering tenecteplase to the human in a total dose of about 0.05 to 0.5 mg/kg, given as (a) an initial bolus dose of about 0.015 to 0.15 mg/kg, followed by infusion of an amount equaling the total dose minus the initial dose over a period of about 50-90 minutes, or (b) a bolus. Also described are kits for carrying out this method.

Preferred systems for assisting clearance of an acutely thrombosed artery substantially surrounded by boney external body surfaces which are resistant to deformative displacement relative to the thrombosed artery by the application of external percussive force are described. The method consists of applying targeted, localized, non-invasive, high infrasonic to low sonic frequency vibratory percussion with a serial impact frequency much greater than the pulse rate of a patient being treated, the percussion directed towards a remote, preferably superficial “target vessel” residing palpably close to the skin surface. Marked vessel deformations with resultant blood pressure and flow fluctuations are thereby induced by the percussion within the target vessel which propagate to the acutely thrombosed artery to provide localized agitation and turbulence to assist thrombolytic and/or IV microbubble delivery and effectiveness in facilitating reperfusion. Preferred apparatus for treatment of ST elevation myocardial infarction, acute ischemic stroke and acute pulmonary embolus are presented.

The invention concerns the use of a mast cell activation- or degranulation-blocking agent in the manufacture of a medicament for the treatment of cerebral ischemia. The invention also relates to treatment of patients suffering from acute ischemic stroke, acute hemorrhagic stroke, subarachnoid hemorrhage, cerebral venous thrombosis or global cerebral ischemia associated with cardiac arrest. Further, the invention provides compositions of contrast media or similar exogenous media, which are intended for use in diagnostic or therapeutic applications for introduction into the intravascular, intrathecal or the intracranial space, comprising a mast cell degranulation-blocking and/or mast cell activation-blocking agent.

The invention provides a method and device for segmenting cerebral ischemia areas in diffusion-weighted images. The method comprises the following steps of: dividing diffusion-weighted images of a plurality of super-acute ischemic stroke patients into test images and training images; training a random forest model, a learning dictionary and a support vector machine model according to the trainingimages; carrying out initial cerebral ischemia area segmentation by utilizing the trained random forest model according to grey features of voxels in the test images; determining a sparse encoding matrix of a local image block feature vector of each voxel in connected regions on the basis of the trained learning dictionary; and classifying each connected area by utilizing the trained linear support vector machine model according to a package feature of each connected area, and deleting the connected areas, in which non-ischemic tissues are located, from a first initially segmented image so asto obtain an optimal segmented image. According to the method and device, automatic recognition and segmentation of super-acute cerebral ischemia areas can be solved, and the ischemia area segmentation precision is improved.

Disclosed is an antithrombotic neurovascular device useful for the treatment of brain aneurysms and/or acute ischemic stroke. The device comprises a mechanical structure, which may be a stent, stent-like structure, or flow diverter, and a drug-eluting coating. This device is designed for local delivery of antiplatelet medication to the site of device implantation in order to improve outcomes for the population of brain aneurysm and/or acute ischemic stroke patients currently being treated with stents, and for use with patients presenting with ruptured aneurysms, in whom systemic dual antiplatelet therapy is contraindicated. The coating comprises an antiplatelet drug, preferably, a GPIIb/IIIa receptor inhibitor, more preferably, abcixmab, and optionally comprises a polymeric binder that functions as a drug modulating polymer. Also disclosed are methods for producing the antithrombotic neurovascular device, and using the device for the treatment of brain aneurysms and/or acute ischemic stroke.

The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke from other forms of stroke and TIAs and “stroke mimic” events. Moreover, methods and compositions are provided to facilitate the treatment of acute ischemic stroke patients.

The invention relates to systems and methods for diagnosing strokes. In particular, systems and methods for acquiring timely patient status information are described that enable a physician to make diagnostic and treatment decisions relating to strokes. The systems and methods enable the efficient and quantitative assessment of arterial collaterals within the brain for aiding these decisions in the case of ischemic strokes.

A method and apparatus for image region segmentation of ischemic stroke are disclosed. The method comprises the following steps: preprocessing the CTP sequence diagram of the first intracranial computed tomography perfusion imaging to obtain the CTP sequence diagram of the intracranial after preprocessing; Inputting the preprocessed intracranial CTP timing diagram into a first network for processing to obtain a first nuclear magnetic resonance MRI image corresponding to the preprocessed intracranial CTP timing diagram; inputting the first MRI image into a second network for processing to obtain a region segmentation image of ischemic stroke. A corresponding device is also disclosed. Through a series of convolution operations on the CTP timing diagram, the CTP timing diagram is automatically and efficiently divided into cerebral infarction region, penumbra region and background region. The whole process does not require manual participation, which can effectively avoid the error causedby manual participation, save human cost, and can efficiently and fast complete the CTP timing diagram distinction.

A slow-releasing aspirin table for treating acute ischemic apoplexy and cerebrovascular and cardiovascular diseases is prepared from aspirin and auxiliaries through proportionally mixing hydroxypropyl methylcellulose, polyacrylic resin II and aspirin, mixing with the solution of hydroxypropyl methylcellulose in alcohol to obtain soft material, granulating by nylon sieve, drying, and loading in capsules, or further mixing with talc powder and tabletting. Its advantages are stable concentration in blood and durable curative effect.

The invention discloses application of lncRNA (long non-coding ribonucleic acid) to diagnosing cerebral ischemic stroke. The lncRNA is LOC101929707. The application has the advantages that correlation between LOC101929707 genes and occurrence and development of the cerebral ischemic stroke is discovered, and accordingly the LOC101929707 can be used as a possible detection target to be applied to early diagnosing the cerebral ischemic stroke on the basis of the correlation.

The invention discloses an acute ischemic stroke focus automatic segmentation method and system. The method comprises the following steps of: registering a head CT (Computed Tomography) image; removing the skull to obtain a brain parenchyma three-dimensional mask; performing ellipse fitting on the brain parenchyma three-dimensional mask through PCA feature dimension reduction to obtain median sagittal plane data; calculating left and right symmetric parameter diagrams of the brain; setting different window widths and window levels for the median sagittal plane data to obtain multi-level window width and window level image data; marking training data; training a segmentation convolutional neural network model; inputting test data into the trained segmentation model for segmentation to obtain a segmentation probability graph of the brain parenchyma, the cerebrospinal fluid and the stroke focus of the corresponding voxel and a prediction probability of whether the stroke focus exists in the corresponding two-dimensional image; and outputting different segmentation results according to different prediction probabilities. According to the method, multi-task training is carried out in combination with brain anatomy priori knowledge, the performance of the convolutional neural network in the NCCT stroke focus automatic segmentation method is improved, and the acute ischemic stroke focus can be accurately segmented.

An apparatus and method of use for a comprehensive transcranial low-level light therapy for use with ischemic brain tissue using a multitude of polychromatic Light Emitting Diodes (LEDs) embedded into a flexible head covering that stretches securely around the patient's cranium to bath the entire cranium cavity in a variable frequency, variable power density light spectrum, maximizing all beneficial effects to the cellular tissues whether or not they are specifically deprived of blood from the ischemic stroke event. The bulbs covering the n-p junction of the semiconductor LEDs directly contact the patient's cranial skin to maximize the depth of penetration of the wavelengths into the brain's cortex cells. By using many individual point-source LEDs emitting all around the cranium, greater therapeutic benefit can be achieved as more of the cortex tissues are irradiated.

The invention relates to methods of treating stroke comprising administration of a VLA-4 antagonist to a subject after the onset of the stroke, e.g., ischemic stroke (e.g., acute ischemic stroke) or hemorrhagic stroke (e.g., intracerebral hemorrhage), sub-arachnoid hemorrhage, or traumatic brain injury. Kits and articles of manufacture are also described herein.

The invention relates to the medical field, discloses applications of racemes of pinocembrin, racemes of pinocembrin salt, racemes of pinocembrin precursors or racemes of pinocembrin hydrate in preparation of medicals for preventing and treating cerebral apoplexy, and further discloses the application of racemes of pinocembrin in prevention and treatment of acute ischemic stroke.

The invention provides an intracranial hemorrhage transformation model after acute cerebral ischemia mechanical recanalization and a microRNA screening method and application thereof. The intracranialhemorrhage transformation model after acute cerebral ischemia mechanical recanalization is established by using a hyperglycemia combined suture-occluded method MCA for occlusion for 5 hours and thenrecanalization for 19 hours. The intracranial hemorrhage transformation model has 33 microRNAs expressions with significant difference. A new method for the study of intracranial hemorrhage transformation after acute cerebral ischemia mechanical recanalization, and an innovative means for the diagnosis and treatment of reperfusion injury after endovascular interventional recanalization in acute ischemic stroke is provided.

The invention discloses a thrombus extraction scaffold. Specifically, the thrombus extraction scaffold comprises a scaffold body and a push rod; the scaffold body is formed by cutting a metal tube, and the cut metal tube is in a shape of helical crossing of a plurality of strands of metal ribs; the metal ribs are gathered to form a first gathering point at the far end of the scaffold body, the near end of the scaffold body is in a diagonal shape, and the metal ribs are gathered to form a second gathering point at the near end of the scaffold body; developing wires are attached to any strand ofthe metal ribs, and the developing wires are attached to the metal ribs; a notch is formed in the second gathering point, the far end of the push rod is provided with an insert matched with the notch, the notch and the insert are assembled and fixed through embedding, and the scaffold body and the push rod are connected to form a whole. The thrombus extraction scaffold is used for mechanically extracting thrombi blocking intracranial vessels when acute ischemic stroke of a patient happens, so that the treatment purposes of revascularization and blood flow recovery are achieved.

The invention relates to a Chinese medicinal preparation for treating acute ischemic stroke with a good treatment effect and high safety. The Chinese medicinal preparation is prepared from the following raw materials in parts by weight: 15 parts of red paeony roots, 9 parts of szechuan lovage rhizome, 15 parts of earthworms, 20 parts of danshen roots, 30 parts of siegesbeckia herb, 30 parts of roots of kudzuvine roots, 15 parts of tree peony root bark, 15 parts of twotooth achyranthes roots, 30 parts of suberect spatholobus stems, 15 parts of ground beetles, 9 parts of peach seeds, 6 parts of leeches and 3 parts of safflowers. The Chinese medicinal preparation provided by the invention is effective in treatment of both symptoms and root causes and has the efficacies of combining warming and heat clearing, promoting the circulation of qi and blood, dispersing blood stasis, dredging collaterals, relaxing muscles and relieving muscular spasm. The Chinese medicinal preparation has a significant effect of improving the neurological impairment of a patient with the acute ischemic stroke due to qi deficiency and blood stasis without causing adverse effects on liver and kidney functions, urine and blood routine, and in addition, the Chinese medicinal preparation can be used for treating acute ischemic stroke safely.

The invention discloses a SNP marker relevant with treatment of ischemic stroke through antiplatelet drug clopidogrel and application thereof, as well as a special amplification primer and a special extension primer for detecting the marker. The SNP marker is combination of rs6686001, rs2302429, rs2242480, rs4244285 and rs2046934. Sequences of each marker, the special amplification primer and the special extension primer are sequentially respectively as shown in SEQ ID No. 1-20. According to the SNP marker combination, clopidogrel-resistant and clopidogrel-effective ischemic stroke people can be distinguished well. The SNP marker, the amplification primer thereof and a relevant kit can be used for clinical medication guidance for adopting the antiplatelet drug clopidogrel to treat ischemic stroke patients, medicine resistance is prevented, and a treatment effect is enhanced.