92 results about "Internal hemorrhage" patented technology

An ultrasound catheter with fluid delivery lumens, fluid evacuation lumens and a light source is used for the treatment of intracerebral hemorrhages. After the catheter is inserted into a blood clot in the brain, a lytic drug can be delivered to the blood clot via the fluid delivery lumens while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the fluid evacuation lumens.

Methods and compositions are provided for the treatment of a patient with intracranial hemorrhage (ICH). Methods include the use of the products of recombinant constructs such as those that contain lactoferrin, as well as fusion protein constructs of lactoferrin and Fc domain for IgG.

An implantable device is provided for controlling hemorrhage in a body cavity, comprising an expandable balloon and a conduit for supplying a physiologically compatible fluid to inflate the balloon. When the balloon tamponade device is implanted or inserted into the body cavity, it is inflated with a physiologically suitable fluid, so that the balloon generally conforms to the body cavity and exerts compressive force against the walls, tissues or structures of the body cavity to control hemorrhage. The balloon may have a deforming means to limit expansion of the balloon in a direction to facilitate expansion of the balloon in another direction. The device may have additional tubes within the conduit, or a plurality of separate lumens within the conduit or tubes to allow drainage and irrigation to the body cavity. There is also provided a cuff for attachment of an external traction to the balloon tamponade, to facilitate the compressive effect of the device. In a preferred embodiment, there is provided a dual balloon tamponade in which two balloons are axially spaced along the conduit, providing a means to control hemorrhage from two distinct body cavities, such as a uterus and a vagina. There is also provided a method to control hemorrhage in a body cavity by implantation or insertion of the balloon tamponade, inflating the balloon with a fluid to a sufficient pressure and retaining the fluid pressure within the balloon for a sufficient period of time to determine whether hemorrhage has been controlled. A kit comprising the balloon tamponade apparatus is also provided.

The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.

Pharmaceutical compositions are disclosed suitable for parenteral administration having anti-inflammatory, analgesic, and anti-pyretic properties, which consist of a therapeutically effective amount of d,l or l-lysine salt of R,S or S-ibuprofen as active ingredient dissolved in sterile water to form a solution in the absence of an inert atmosphere and either substantially free or absolutely free of any excipient, organic solvent, buffer, acid, base, salt other than the active ingredient and capable of storage in the absence of an inert atmosphere. Also disclosed are methods employing the new compositions in the treatment of pain and inflammation, in reducing fever and in treating patent ductus arterious or intraventricular hemorrhage in prematurely born neonates.

Passive physiological monitoring apparatus has a sensor for sensing physiological phenomenon and method converter converts sensed data into electrical signals and a computer receives and computes the signals and output computed data for real-time interactive display. The sensor is a piezoelectric film of polyvinylidene fluoride. Signals detected include mechanical, thermal and acoustic signatures reflecting cardiac output, cardiac function, internal bleeding, respiratory, pulse, apnea and temperature. The sensor may be an array provided in a MEDEVAC litter or other device for measuring acoustic and hydraulic signals from the body of a patient for field monitoring, hospital monitoring, transport monitoring, home, remote monitoring.

Methods and systems for detecting internal hemorrhaging in a person are provided. In an exemplary embodiment, one method includes the steps of measuring physiological conditions associated with the person and processing the measured physiological conditions using a probabilistic network to determine if the person has internal hemorrhaging. The method also includes the steps of determining the severity of any internal hemorrhaging by determining the amount of blood lost by the person and classifying this loss as non-specific, mild, moderate, and severe. The physiological measurements include an electrocardiogram, a photoplethysmogram, and oxygen saturation, respiratory, skin temperature, and blood pressure measurements. The probabilistic network included with one system determines whether there is internal hemorrhaging based on a number of factors including a physiological model, medical personnel inputs, transfer function, statistical, and spectral information, short and long term trends, and previous hemorrhage decisions.

The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.

The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.

A vascular closure device, comprising an anchor member; a compressible plug; a locking mechanism; and a sensor probe, the sensor probe including a first electrically conductive member having a proximal end and a distal end and a second electrically conductive member having a proximal end and a distal end, the first electrically conductive member being electrically insulated from the second electrically conductive member from the proximal end to the distal end.

Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.

The present invention is directed to liquid, aqueous pharmaceutical compositions containing Factor VII polypeptides, and methods for preparing and using such compositions, as well as vials containing such compositions, and the use of such compositions in the treatment of a Factor VII-responsive syndrome, e.g., bleeding disorders, including those caused by clotting Factor deficiencies (e.g. haemophilia A, haemophilia B, coagulation Factor VII deficiency); by thrombocytopenia or von Willebrand's disease, or by clotting Factor inhibitors, and intra cerebral haemorrhage, or excessive bleeding from any cause. The preparations may also be administered to patients in association with surgery or other trauma or to patients receiving anticoagulant therapy. More particularly, the invention relates to liquid compositions stabilised against chemical and / or physical degradation. The main embodiment is represented by a liquid, aqueous pharmaceutical composition comprising a Factor VII polypeptide (i); a buffering agent (ii) suitable for keeping pH in the range of from about 4.0 to about 9.0; at least one metal-containing agent (iii), wherein said metal is selected from the group consisting of first transition series metals of oxidation state +II, except zinc, such as chromium, manganese, iron, cobalt, nickel, and copper; and a non-ionic surfactant (iv).

Disclosed is an anti-blockage urinary catheter, comprising a catheter body (1) and a balloon (2), wherein the balloon is provided on the catheter body at a site close to the tail end and the balloon is provided with a filter net (3) outside, wherein the filter net coats the tail end of the catheter body and is ovoid when in the open state. After placing the urinary catheter into the bladder, air is inflated into the balloon or water is injected into the balloon, in order to fully open the balloon and stretch the filter net to contact with the liquid in the bladder in the maximum area, thus preventing the bladder from bleeding to form blood clots, bladder stones and bladder mucosa to block the pipe orifice thus leading to overactive bladder filling.

The invention relates to a lattice open-window type aortic stent assembly for a transplantation operation. An elastic support is arranged in a main support, and a wrapping layer is arranged on the exterior of the main support; a lattice open-window plate is in an arc shape, a transverse opening fits the wrapping layer of the main support, and open-window lattice holes are formed in the lattice open-window plate; a laser pen extends into the open-window lattice holes fitting the wrapping layer and scalds the wrapping layer to form an open-window lattice; a guiding wire extends into one hole ofthe open-window lattice; one end of an inflation balloon is a balloon body, the other end of the inflation balloon is an inflation joint, the balloon body and the inflation joint are connected througha catheter, and the inflation joint conducts inflation and deflation on the balloon body through an air pump to expand the hole, where the guiding wire is located, of the open-window lattice; a branch support extends into the hole, expanded by the balloon body, of the open-window lattice. Alignment of a branch artery on the aortic arch can be easily and accurately achieved, blood supply of a branch on the aortic arch cannot be influenced, ischemia cannot be caused, and I-type internal hemorrhage cannot be caused when the assembly is released from the holes of the open-window lattice.

The invention provides a method of treating a premature infant at a statistical risk of sustaining an intraventricular hemorrhage. The method, or therapeutic protocol, can include at least one or more of the following steps: identifying premature infants at a statistical risk of having an intraventricular hemorrhage, collecting umbilical cord blood from the identified premature infant, separating totipotential stem cells (e.g., having the ability to proliferate and differentiate as neural stem cells) from the collected cord blood, storing the separated stem cells, establishing evidence of an intraventricular hemorrhage (preferably prior to Grade III / IV if possible) in the premature infant, and intrathecally administering the autologous cord blood derived stem cells to the premature infant.

The invention discloses a plugging device for far end tears of aortic dissection. The plugging device comprises a bare stent system and a plugging device body. A bare stent is accurately positioned and released by a bare stent releasing device, and the axial length can be limited and fixed by limiting rods; the plugging device body is composed of a big disc, a small disc and a short waist, the bigdisc and the small disc are in an arc shape from overlooking, a circle of bent hooks pointing to the circle center are arranged on the inner side of the small disc, the section of the short waist canbe in different shapes, and the contact surfaces of the short waist with the big disc and the small disc are sewn and wrapped by flexible blood impermeable materials. The plugging device is used forplugging the far end tears of the aortic dissection, can be matched with the tears of the dissection in shape, reduce internal hemorrhage and the risk of falling of the plugging device body, reduce hurt to inner walls of blood vessels by the big disc and the small disc, and adapt to the pathogenic structures of existing branched blood vessels nearby the tears, and reduces physical hurt to the inner wall of a false lumen by the big disc located in the false lumen.

The invention discloses an anorectum support drainage tube for infants. The anorectum support drainage tube comprises a transparent catheter with a round periphery and smooth lines, elliptical quick discharge holes, an inverted-gourd-shaped air bag and a conical disc-shaped buckle. Scales are arranged on the wall of the catheter, an oblique plane at the angle ranging from 30 degrees to 50 degrees is arranged at an upper port, the elliptical quick discharge holes are formed in two sides of the catheter and are positioned below the upper port, the inverted-gourd-shaped air bag annularly sleeves a position below the quick discharge holes of the catheter, and the conical disc-shaped buckle annularly sleeves a position below the inverted-gourd-shaped air bag on the catheter. The anorectum support drainage tube has the advantages that the anorectum support drainage tube can bring convenience for observing anastomotic stomas, is large in relative vertical plane drainage area and can bring convenience for quickly effectively discharging different types of intestinal juice, secretion and feces in intestinal tracts, the anorectum anastomotic stoma can be uniformly compressed, internal hemorrhage can be reduced, and anastomotic stoma scar contracture can be prevented and treated; the anorectum support drainage tube is easy to operate, tube change operation can be carried out at any time as needed, suture fixation can be omitted, and accordingly suffering of child patients can be relieved; different models of anorectum support drainage tubes with different sizes and lengths can be selected according to growth and development characteristics of the infants; the anorectum support drainage tube is suitable for postoperative posterior anorectum anastomotic stoma treatment on the infants.

The invention relates to an intracranial hemorrhage detection model with optimized and enhanced window adjustment and a construction method of the intracranial hemorrhage detection model. The invention provides an intracranial hemorrhage detection model on one hand. The intracranial hemorrhage detection model comprises a window adjustment optimization enhancement module and a RetinaNet network. The window adjustment optimization enhancement module is constructed by a 1 * 1 convolution layer and a window activation function layer. The network comprises a basic feature extraction network, an FPNfeature pyramid and a classification and regression sub-network. On the other hand, the invention also provides a construction method of the intracranial hemorrhage detection model with optimized andenhanced window adjustment. The construction method comprises the following steps: step 1, preparing a craniocerebral CT examination data set and carrying out data preprocessing; step 2, constructingan intracranial hemorrhage detection model; step 3, training an intracranial hemorrhage detection model; and step 4, verifying the intracranial hemorrhage detection model. According to the invention,the contrast between a bleeding area and a normal tissue is enhanced through the window adjustment optimization module, and the accuracy of model detection is greatly improved by combining the feature extraction of ResNet and the setting of a network.

A compound of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, Wherein Q, R2, Ar, A and R1 are as defined in claim 1. The claimed compounds are gap junction blockers useful for the treatment or prevention of a range of conditions including migraine, epilepsy, non-epileptic seizures, brain injury (including stroke, intracranial haemorrhage and trauma induced), pain, neurodegenerative disease or cardiovascular disease including myocardial infarction, coronary revascularization or angina.

Novel ApoE peptide derivatives and ApoE-protein transduction domain conjugates are disclosed which are useful for treating disorders including subarachnoid hemorrhage, intracerebral hemorrhage, and intraventricular hemorrhage and other brain disorders. The invention encompasses methods for treating cerebral vasospasm by administration of at least one ApoE or ApoE mimetic peptide.

The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.

A system is provided for detecting fluid accumulation in a subject. A movement induced by the beating of the heart is analyzed over time, by monitoring a movement, pressure or force. Changes in density caused by fluid accumulation result in changes in the sensor arrangement signals. Changes are used to indicate that fluid accumulation such as internal bleeding is likely to have taken place.

The invention relates to the use of Factor VIIa or a Factor VIIa equivalent for the manufacture of a medicament for preventing complications in ICH patients.

The Chinese medicine for treating internal hemorrhage is prepared with bigleaf beautyberry and Diren. The Chinese medicine has the functions of clearing away heat, cooling blood, removing blood stasis, arrest hemorrhage, etc. and is used in treating internal hemorrhage of digestive tract, respiratory tract, etc.

The invention relates to a traditional Chinese medicine composition for preventing intestinal tract diseases and internal hemorrhage diseases of a frog, and belongs to the field of the traditional Chinese medicine. The composition is prepared from the following raw materials by weight part: 15 to 35 parts of rhubarb, 10 to 20 parts of radix scutellariae, 5 to 15 parts of phellodendron, 5 to 15 parts of common andrographis herb, 10 to 30 parts of crow Chinese arborvitae twig, 60 to 100 parts of fresh chives and 40 to 80 parts of salt. According to the pharmaceutical analysis of the common diseases of the frog, the invention selects the crude drugs mainly based on the diseases of the gastrointestinal tract digestive system, the infection of the skin respiratory system, hemorrhage, etc., to regulate and control the water quality and prevent the diseases, so that the frog is in a non-disease state, for example, the frog can keep the stomach intestine normal and healthy and keep the skin smooth and active, thereby achieving the purpose of healthy culture.

Systems, methods and kits for treating hemorrhages within cavities are provided. The methods utilize the application of a rapid spike of pressure to the closed cavity, followed by a steady state pressure or pressures.

The invention discloses a construction method of an atherosclerosis vulnerable plaque mouse model. According to the method, a low-density lipoprotein receptor gene (LDLR) with heterozygous point mutation in a fibrillin-1 (Fbn1) gene is obtained through a hybridization method to knock out a mouse. According to the method, Fbn1C1039G+ / - point mutation is introduced into an LDLR- / - mouse genome for the first time, characteristics of two genotypes are combined, the method is simple and easy to implement, and vulnerable plaques with large lipid cores, a large number of inflammatory cells, typical thin fibrous caps, rich new blood vessels and the characteristics of plaque internal hemorrhage, vascular outward reconstruction and the like can be formed; the occurrence of acute cardiovascular and cerebrovascular events such as plaque rupture similar to that of the human body can be observed on the model. The method is high in model forming rate and good in repeatability, a good animal foundation is provided for medicine research and instrument consumable improvement, and a good platform is provided for exploring an atherosclerosis mechanism.

The invention discloses application of N-acetylserotonin in preparation of a drug for treating intraventricular hemorrhage and belongs to the technical field of biomedicines. The invention discloses and proves that the N-acetylserotonin can relieve cerebral edema and blood brain barrier destruction caused by the intraventricular hemorrhage; it is discovered that the N-acetylserotonin has an improvement effect on sports and learning memory disorder induced by the intraventricular hemorrhage; it is disclosed that a protection effect of the N-acetylserotonin is related to relief of oxidative stress, inhibition of ferroptosis and improvement on synaptic plasticity; and in addition, in a primary cortex neuron haemorrhage cell model, it is proven that the NAS can obviously inhibit neuron death induced by Hemin and relieve axon injury. According to the application, a scientific basis is provided for utilizing the N-acetylserotonin to treat the intraventricular hemorrhage as a novel drug.

The invention provides a Chinese medicinal composition for treating traumatic injury. The Chinese medicinal composition is prepared from pseudo-ginseng, raw safflower, angelica sylvestris, frankincense, myrrh, cinnabar, radix trichosanthis, liquorice and agilawood supplemented by giant typhonium rhizome, gastrodia elata, arisaema, divaricate saposhnikovia root, angelica dahurica, dipsacus asperoides, eucommia bark, fructus psoraleae, aniseed, lycopodium calvatum, Chinese starjasmine, rhizoma cibotii, white peony root, clematis chinensis, large-headed atractylodes root and other various raw material drugs. The raw material drugs can be made into various common preparations together with various carriers, and the obtained preparations can be taken orally or applied externally. The Chinese medicinal composition provided by the invention has wonderful effects in treating new and old injuries of soft tissue injury, external hemorrhage, internal hemorrhage, skeleton injury and hyperosteogeny caused by traumatic injury.