82 results about "Internal hemorrhage" patented technology

The invention provides compositions and methods for targeted controlled drug release. The compositions and methods can be used for treating or imaging vascular stenosis, stenotic lesions, occluded lumens, embolic phenomena, thrombotic disorders and internal hemorrhage.

Methods and systems for detecting internal hemorrhaging in a person are provided. In an exemplary embodiment, one method includes the steps of measuring physiological conditions associated with the person and processing the measured physiological conditions using a probabilistic network to determine if the person has internal hemorrhaging. The method also includes the steps of determining the severity of any internal hemorrhaging by determining the amount of blood lost by the person and classifying this loss as non-specific, mild, moderate, and severe. The physiological measurements include an electrocardiogram, a photoplethysmogram, and oxygen saturation, respiratory, skin temperature, and blood pressure measurements. The probabilistic network included with one system determines whether there is internal hemorrhaging based on a number of factors including a physiological model, medical personnel inputs, transfer function, statistical, and spectral information, short and long term trends, and previous hemorrhage decisions.

The invention provides compositions and methods for treating or imaging stenosis, stenotic lesions, occluded lumens, embolic phenomena or thrombotic disorders. The invention further provides compositions and methods for treating internal hemorrhage.

Exemplary apparatus and process can be provided for determining at least one characteristic of an anatomical structure. For example, it is possible to generate an acoustic wave in the anatomical structure using an opto-accoustic arrangement It is then possible to detect the acoustic wave and determine whether at least one blood pool is present at or in the anatomical structure as a function of at least one property of the acoustic wave. Further, it is possible to forward at least one first electro-magnetic radiation to at least one tissue of the anatomical structure, detect at least one second electro-magnetic radiation provided from the at least one tissue based on a motion of or within the at least one tissue to generate detection data, and determine the at least one characteristic of the at least one portion based on the detection data.

Disclosed is an anti-blockage urinary catheter, comprising a catheter body (1) and a balloon (2), wherein the balloon is provided on the catheter body at a site close to the tail end and the balloon is provided with a filter net (3) outside, wherein the filter net coats the tail end of the catheter body and is ovoid when in the open state. After placing the urinary catheter into the bladder, air is inflated into the balloon or water is injected into the balloon, in order to fully open the balloon and stretch the filter net to contact with the liquid in the bladder in the maximum area, thus preventing the bladder from bleeding to form blood clots, bladder stones and bladder mucosa to block the pipe orifice thus leading to overactive bladder filling.

The invention relates to a lattice open-window type aortic stent assembly for a transplantation operation. An elastic support is arranged in a main support, and a wrapping layer is arranged on the exterior of the main support; a lattice open-window plate is in an arc shape, a transverse opening fits the wrapping layer of the main support, and open-window lattice holes are formed in the lattice open-window plate; a laser pen extends into the open-window lattice holes fitting the wrapping layer and scalds the wrapping layer to form an open-window lattice; a guiding wire extends into one hole ofthe open-window lattice; one end of an inflation balloon is a balloon body, the other end of the inflation balloon is an inflation joint, the balloon body and the inflation joint are connected througha catheter, and the inflation joint conducts inflation and deflation on the balloon body through an air pump to expand the hole, where the guiding wire is located, of the open-window lattice; a branch support extends into the hole, expanded by the balloon body, of the open-window lattice. Alignment of a branch artery on the aortic arch can be easily and accurately achieved, blood supply of a branch on the aortic arch cannot be influenced, ischemia cannot be caused, and I-type internal hemorrhage cannot be caused when the assembly is released from the holes of the open-window lattice.

The invention discloses a plugging device for far end tears of aortic dissection. The plugging device comprises a bare stent system and a plugging device body. A bare stent is accurately positioned and released by a bare stent releasing device, and the axial length can be limited and fixed by limiting rods; the plugging device body is composed of a big disc, a small disc and a short waist, the bigdisc and the small disc are in an arc shape from overlooking, a circle of bent hooks pointing to the circle center are arranged on the inner side of the small disc, the section of the short waist canbe in different shapes, and the contact surfaces of the short waist with the big disc and the small disc are sewn and wrapped by flexible blood impermeable materials. The plugging device is used forplugging the far end tears of the aortic dissection, can be matched with the tears of the dissection in shape, reduce internal hemorrhage and the risk of falling of the plugging device body, reduce hurt to inner walls of blood vessels by the big disc and the small disc, and adapt to the pathogenic structures of existing branched blood vessels nearby the tears, and reduces physical hurt to the inner wall of a false lumen by the big disc located in the false lumen.

The invention discloses an anorectum support drainage tube for infants. The anorectum support drainage tube comprises a transparent catheter with a round periphery and smooth lines, elliptical quick discharge holes, an inverted-gourd-shaped air bag and a conical disc-shaped buckle. Scales are arranged on the wall of the catheter, an oblique plane at the angle ranging from 30 degrees to 50 degrees is arranged at an upper port, the elliptical quick discharge holes are formed in two sides of the catheter and are positioned below the upper port, the inverted-gourd-shaped air bag annularly sleeves a position below the quick discharge holes of the catheter, and the conical disc-shaped buckle annularly sleeves a position below the inverted-gourd-shaped air bag on the catheter. The anorectum support drainage tube has the advantages that the anorectum support drainage tube can bring convenience for observing anastomotic stomas, is large in relative vertical plane drainage area and can bring convenience for quickly effectively discharging different types of intestinal juice, secretion and feces in intestinal tracts, the anorectum anastomotic stoma can be uniformly compressed, internal hemorrhage can be reduced, and anastomotic stoma scar contracture can be prevented and treated; the anorectum support drainage tube is easy to operate, tube change operation can be carried out at any time as needed, suture fixation can be omitted, and accordingly suffering of child patients can be relieved; different models of anorectum support drainage tubes with different sizes and lengths can be selected according to growth and development characteristics of the infants; the anorectum support drainage tube is suitable for postoperative posterior anorectum anastomotic stoma treatment on the infants.

A compound of formula (Ia) or (Ib), or a pharmaceutically acceptable salt thereof, Wherein Q, R², Ar, A and R¹ are as defined in claim 1. The claimed compounds are gap junction blockers useful for the treatment or prevention of a range of conditions including migraine, epilepsy, non-epileptic seizures, brain injury (including stroke, intracranial haemorrhage and trauma induced), pain, neurodegenerative disease or cardiovascular disease including myocardial infarction, coronary revascularization or angina.

Novel ApoE peptide derivatives and ApoE-protein transduction domain conjugates are disclosed which are useful for treating disorders including subarachnoid hemorrhage, intracerebral hemorrhage, and intraventricular hemorrhage and other brain disorders. The invention encompasses methods for treating cerebral vasospasm by administration of at least one ApoE or ApoE mimetic peptide.

The Chinese medicine for treating internal hemorrhage is prepared with bigleaf beautyberry and Diren. The Chinese medicine has the functions of clearing away heat, cooling blood, removing blood stasis, arrest hemorrhage, etc. and is used in treating internal hemorrhage of digestive tract, respiratory tract, etc.

The invention relates to a traditional Chinese medicine composition for preventing intestinal tract diseases and internal hemorrhage diseases of a frog, and belongs to the field of the traditional Chinese medicine. The composition is prepared from the following raw materials by weight part: 15 to 35 parts of rhubarb, 10 to 20 parts of radix scutellariae, 5 to 15 parts of phellodendron, 5 to 15 parts of common andrographis herb, 10 to 30 parts of crow Chinese arborvitae twig, 60 to 100 parts of fresh chives and 40 to 80 parts of salt. According to the pharmaceutical analysis of the common diseases of the frog, the invention selects the crude drugs mainly based on the diseases of the gastrointestinal tract digestive system, the infection of the skin respiratory system, hemorrhage, etc., to regulate and control the water quality and prevent the diseases, so that the frog is in a non-disease state, for example, the frog can keep the stomach intestine normal and healthy and keep the skin smooth and active, thereby achieving the purpose of healthy culture.

The invention discloses a construction method of an atherosclerosis vulnerable plaque mouse model. According to the method, a low-density lipoprotein receptor gene (LDLR) with heterozygous point mutation in a fibrillin-1 (Fbn1) gene is obtained through a hybridization method to knock out a mouse. According to the method, Fbn1C1039G+/- point mutation is introduced into an LDLR-/- mouse genome for the first time, characteristics of two genotypes are combined, the method is simple and easy to implement, and vulnerable plaques with large lipid cores, a large number of inflammatory cells, typical thin fibrous caps, rich new blood vessels and the characteristics of plaque internal hemorrhage, vascular outward reconstruction and the like can be formed; the occurrence of acute cardiovascular and cerebrovascular events such as plaque rupture similar to that of the human body can be observed on the model. The method is high in model forming rate and good in repeatability, a good animal foundation is provided for medicine research and instrument consumable improvement, and a good platform is provided for exploring an atherosclerosis mechanism.

The invention discloses application of N-acetylserotonin in preparation of a drug for treating intraventricular hemorrhage and belongs to the technical field of biomedicines. The invention discloses and proves that the N-acetylserotonin can relieve cerebral edema and blood brain barrier destruction caused by the intraventricular hemorrhage; it is discovered that the N-acetylserotonin has an improvement effect on sports and learning memory disorder induced by the intraventricular hemorrhage; it is disclosed that a protection effect of the N-acetylserotonin is related to relief of oxidative stress, inhibition of ferroptosis and improvement on synaptic plasticity; and in addition, in a primary cortex neuron haemorrhage cell model, it is proven that the NAS can obviously inhibit neuron death induced by Hemin and relieve axon injury. According to the application, a scientific basis is provided for utilizing the N-acetylserotonin to treat the intraventricular hemorrhage as a novel drug.

The invention provides a Chinese medicinal composition for treating traumatic injury. The Chinese medicinal composition is prepared from pseudo-ginseng, raw safflower, angelica sylvestris, frankincense, myrrh, cinnabar, radix trichosanthis, liquorice and agilawood supplemented by giant typhonium rhizome, gastrodia elata, arisaema, divaricate saposhnikovia root, angelica dahurica, dipsacus asperoides, eucommia bark, fructus psoraleae, aniseed, lycopodium calvatum, Chinese starjasmine, rhizoma cibotii, white peony root, clematis chinensis, large-headed atractylodes root and other various raw material drugs. The raw material drugs can be made into various common preparations together with various carriers, and the obtained preparations can be taken orally or applied externally. The Chinese medicinal composition provided by the invention has wonderful effects in treating new and old injuries of soft tissue injury, external hemorrhage, internal hemorrhage, skeleton injury and hyperosteogeny caused by traumatic injury.

The invention discloses a composite hemostatic syringe, and relates to the field of medical apparatuses. The composite hemostatic syringe comprises an outer drum and an inner drum, wherein an outer drum base is arranged at the back end of the outer drum and an outer front cover is connected to the front end of the outer drum; a crack is formed in the outer front cover; an outer piston is arranged in the outer drum and an outer fastener is fixedly arranged inside the outer piston; an inner cuff is connected to the back end of the inner drum; an inner front cover is connected to the front end of the inner drum; a through hole is formed in the inner front cover; a first hemostatic substance is arranged between the inner drum and the outer drum; an inner piston and a second hemostatic substance are arranged in the inner drum; an inner fastener is fixedly arranged in the inner piston; a hollow core rod is penetrated in the inner drum; a core rod is penetrated in the hollow core rod; one end of the core rod is connected to a handle; the core rod and the outer piston are clamped by virtue of the outer fastener as the core rod is pulled out; the inner cuff and the outer drum are clamped by virtue of a drum fastener as the inner drum extends out of the interior of the outer drum; and the hollow core rod and the inner piston are clamped by virtue of the inner fastener as the hollow core rod is pulled out. With the application of the composite hemostatic syringe provided by the invention, internal hemorrhage can be controlled.

The invention relates to the technical field of medical equipment and discloses a rapid bleeding arresting structure for an internal hemorrhage sufferer for ICU emergency nursing. The rapid bleeding arresting structure comprises a framework, wherein a refrigerating device is fixedly mounted at the internal left end of the framework, a driving wheel is fixedly mounted at the internal right end of the framework, a control device is fixedly mounted at the right end of the driving wheel, and a rotating ring is rotatably or fixedly mounted inside the framework. According to the rapid bleeding arresting structure for an internal hemorrhage sufferer for ICU emergency nursing, the driving wheel is controlled to rotate through the control device, then, the rotating ring is driven to rotate by the driving wheel and is matched with a fixed block so as to drive a shifting bar to move inside a fixed ring, and clamping levers close to connecting rings can be close to each other during moving of theshifting bar inside an arc-shaped groove , so that a medial-extremity blood vessel above a wound of the sufferer can be pressed and is forced to stop bleeding, and thus, a better bleeding arresting effect can be achieved on the basis of cooling.

The invention relates to a method for establishing a rat cerebral hemorrhage model by combining ultrasound with microbubbles, and belongs to the technical field of biological model preparation. The method is implemented by the following steps of 1) taking one SPF-grade male SD rat with the body mass of 240-270 g; 2) making preparation work; 3) with the help of an auxiliary tool, injecting a microbubble contrast agent from the tail vein of the rat, wherein the injection amount is determined according to the body mass of the rat; 4) performing ultrasonic intervention; 5) carrying out CT plain scanning on the head of the rat; 6) irradiating the rat with an incandescent lamp for at least 2 hours, and keeping the anal temperature at 37+/-0.5 DEG C; and 7) scoring the neurological function of the rat, and feeding and observing the rat for later use. According to the method, the contrast agent is ultrasonically targeted, and local blood vessels in an intracerebral target area are destroyed byvirtue of the instantaneous cavitation effect of the microbubbles, so that the rat has an intracerebral parenchymal hemorrhage phenomenon, and the research requirement of spontaneous cerebral hemorrhage is met; the method has the advantages of noninvasiveness, simplicity, convenience and easiness in popularization and is a proper reproducible biological modeling method; and meanwhile, auxiliary equipment is introduced, so that the operation is simpler, more convenient and more feasible.

A device to increase intra-abdominal compartment pressure for the controlling of internal hemorrhages is presented. The device controls internal hemorrhaging by supplementing the occlusion effectiveness of a pneumatic tourniquet with a shaped device that increases the overall internal pressure in a human compartment, such as the upper abdomen, to assist in the cessation of bleeding in that region. One side of the device includes a flat base that is adapted to be placed against a patient at the targeted body site. The other side has a generally corrugated shape that is sized to receive an inflatable, wedge-shaped bladder from the pneumatic tourniquet. The overall shape of the invention includes a tapered upper end that corresponds with the inferior angle of the lower ribs in a human torso so that when pressed against the patient by the pneumatic tourniquet bladder a uniform distribution of pressure occurs over the upper abdomen region.

The invention discloses a traditional Chinese medicine composition for treating gingival hemorrhage and tooth slit internal hemorrhage, relating to the field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 12-15 parts of gypsum, 3-6 parts of scutellaria root, 3-6 parts of raw rehmannia root, 3-6 parts of cortex moutan, 3-6 parts of rhizoma cimicifugae, 5-8 parts of mirabilite and 5-8 parts of licorice root. The traditional Chinese medicine composition is prepared through combining modern latest scientific research achievements based on the differential treatment of the traditional Chinese medicine, and has the characteristics of definite curative effect, safety, convenience, no toxic or side effects and low cost.