38 results about "Internal hemorrhage" patented technology

APRIL research shows that in a selected stroke patient, infusion of 0.2 mg / kg of ApTOLL (SEQ ID NO: 1) in combination with intravascular treatment is safe, and the death rate of 90 days is reduced. ApTOLL has proved to limit intracranial hemorrhage and reperfusion injury which may occur after recanalization, and also improve early nerve injury and long-term disability. ApTOLL molecules are provided for reducing the risk of intracranial or secondary bleeding after acute ischemic stroke, reducing nerve injury, and improving nerve recovery in a subject.

Provided herein are ultrasound imaging systems and methods of estimating a size / volume of an anatomical feature of a subject using an ultrasound imaging system. As described, the systems and methods combines automatic image segmentation through artificial intelligence with inertial measurement unit data to improve the accuracy of organ and tissue volume measurements. The systems and methods described herein can be applied to measure a number of different anatomical features (e.g., an organ, a tumor, a fluid region, a cyst, and / or an intraperitoneal hemorrhage), and cam assist in diagnosing conditions such as organ hypertrophy or atrophy.

The invention relates to 4 serum peptide patterns for diagnostics of intracranial hemorrhagic stroke (ICH) in humans and differential diagnosis from acute ischemic stroke that are defined using a list of the 34 quantitative peptides that in sera of patients with ICH are increased 2 folds or more as compared with individuals without stroke and patients with acute ischemic stroke and a list of 16 qualitative peptides detectable in sera of the patients with ICH but not detectable in the sera of individuals without stroke and in sera of patients with acute ischemic stroke.

Embodiments of the present application relate to the field of measurement technology for diagnostic purposes, and particularly relate to an intracranial hemorrhage detection device and a containing part thereof. The containing part is used for mounting an antenna and a flexible headgear, and comprises a peripheral part, an end part, a plurality of antenna mounting parts and a headgear mounting part. The peripheral part is connected with the end part to jointly form a containing space for containing a patient's cranium. The headgear mounting part is used for mounting the flexible headgear in the containing space. Each antenna mounting part is used for mounting one antenna on the peripheral part to face the flexible headgear. Embodiments of the present application can mount the flexible headgear in the containing space by providing the headgear mounting part, and can mount the antenna on the peripheral part to face the flexible headgear by providing the antenna mounting part, thereby facilitating the assembly of the intracranial hemorrhage detection device. Moreover, the antenna can directly emit and receive microwave signals to and from the flexible headgear, and the transmission efficiency of the microwave signals can be improved through the flexible headgear.

The utility model discloses an internal fistula side limb fixer for a hemodialysis patient during defecation, which comprises a first fixing plate and a second fixing plate, a plurality of fixing seats are arranged on the first fixing plate and the second fixing plate, arc-shaped limiting rings are arranged on the fixing seats, and restraint straps are arranged in the arc-shaped limiting rings; shoulder straps are arranged at one ends of the first fixing plate and the second fixing plate. When the fixator is used, an internal fistula side limb can be placed in the fixator, and internal hemorrhage caused by excessive movement of the limb is prevented; the contact surface between the inner side of the fixator and the limbs is made of breathable perforated fabric which is comfortable and skin-friendly; a restraint strap and a first hook-and-loop fastener are arranged outside the fixator, the size of the fixator can be adjusted to be proper according to the size of the arm circumference of a patient, the shoulder strap is arranged, the limb on the internal fistula side can be kept in a straightened state when the patient goes to the toilet, and a puncture needle is better protected; the second hook-and-loop fastener can prevent the puncture needle from slipping due to the fact that the puncture needle is pulled when the patient goes to the toilet.

Processes are provided based on an interventional (device-based) approach to minimize the development of intramyocardial hemorrhage within the myocardial infarction (MI) zone. In one exemplary process, the revascularization occurs in an incremental fashion prior to fully opening the vessel, so as to modulate the hydrostatic pressure transmitted from the proximal end of the catheter, prior to placing a stent. In another exemplary process, the stent will be placed within the central core of the embolization and will slowly expand within the lumen reaching full patency over a period of time. Devices operated with these processes can also greatly reduce the chance of development of intramyocardial hemorrhage with the MI zone. These developments can improve the outcome in hemorrhagic patients, who otherwise carry a significant risk for heart failure and sudden death.

The invention discloses a first-aid device for filling thoracic cavity for hemostasis of an open thoracic wound, and relates to the technical field of medical instruments, the first-aid device for filling thoracic cavity for hemostasis of the open thoracic wound comprises an imbedding unit, a pressure management unit and a fixing unit, the imbedding unit is used for entering the thoracic cavity through the wound; the pressure management unit is connected with the implantation unit and can be used for pressurizing the implantation unit and monitoring the pressure, so that the implantation unit which is deformed after being pressurized is subjected to compression hemostasis in the chest; the fixing unit is connected with the end, located outside the wound, of the imbedding unit and can be fixed to the body surface of a patient and seal the wound. The first-aid device for filling the chest cavity for hemostasis of the open chest wound can be rapidly placed in an external field environment, and the two core problems of wound closing and intracavitary bleeding can be effectively solved at the same time.

The invention discloses an application of sunitinib in preparation of a medicine for treating secondary injury caused by intracranial hemorrhage. It is found for the first time that sunitinib can act on a CSF-1R / PI3K / Akt axis, pathological activation and pro-inflammatory response of microglial cells are effectively inhibited, the normal phagocytic function and lipid metabolism balance of the microglial cells are remarkably recovered, myelin sheath damage around hematoma is effectively relieved, and the neurological function score, the movement coordination ability and the exploration behavior of ICH mice are remarkably improved; the progress of secondary injury caused by intracranial hemorrhage is hindered from multiple dimensions, the curative effect is superior to that of a positive control drug pecetinib (PLX3397), and a brand new molecular target and an interference strategy are provided for comprehensive treatment of ICH.

The invention discloses an application of a pyroptosis pathway inhibitor in protection of plateau brain impact lung injury, the pyroptosis pathway inhibitor is applied to preparation of a medicine for preventing and / or treating lung injury caused by plateau brain impact injury, the pyroptosis pathway inhibitor acts on a Caspase-1 / GSDMD signal pathway, the inhibitor comprises a Caspase-1 inhibitor, an ASC inhibitor or a GSDMD-D inhibitor, and the inhibitor comprises a Caspase-1 inhibitor, an ASC inhibitor or a GSDMD-D inhibitor. The medicine is used for improving lung function impairment caused by plateau brain impact injury. The lung function indexes comprise at least one of the maximum inspiration flow rate, the maximum expiration flow rate, the respiratory rate and the accumulated volume, and the medicine is used for relieving lung tissue pathological injury caused by the plateau brain impact injury; the pathological injury comprises at least one of pulmonary alveolar wall thickening, inflammatory cell infiltration, pulmonary alveolar cavity internal hemorrhage and pulmonary alveolar rupture and fusion into pulmonary bulla. The invention provides a new target spot and strategy for clinical prevention and treatment of the secondary lung injury of the plateau craniocerebral impact injury.

The present application relates to the technical field of medical image processing, and discloses a method and system for predicting vascular injury and assessing internal hemorrhage risk, comprising: acquiring original data, wherein the original data includes body surface marker coordinate data, physiological state and trauma-related information of a critically injured trauma victim; preprocessing the body surface marker coordinate data in the original data to obtain standardized coordinate data; inputting the standardized coordinate data into a pre-trained graph neural network model for mapping processing to obtain vascular marker three-dimensional coordinate prediction data; calculating the spatial distance between the injury path and the vascular marker according to the vascular marker three-dimensional coordinate prediction data and the trauma-related information to obtain a quantitative evaluation result of vascular injury risk; and combining the quantitative evaluation result of vascular injury risk with the physiological state information of the victim to complete comprehensive quantitative assessment of the internal hemorrhage risk of the victim to obtain a corresponding risk level result.

This invention relates to mitochondrial-enriched extracellular vesicles, their preparation methods, and applications, which can effectively solve the drug problem in spontaneous intracerebral hemorrhage. The technical solution involves using platelets as raw material, and obtaining platelet-derived extracellular vesicles carrying active mitochondria through activation induction, differential centrifugation and fractionation, membrane filtration and elution enrichment. This achieves efficient and stable loading of functional mitochondria, and the resulting PEV Mito has a complete structure and uniform particle size, which can effectively maintain mitochondrial membrane potential and biological activity. It can achieve efficient delivery and intracellular internalization to damaged neurons and restore mitochondrial function. The PEV Mito prepared by this invention has high delivery efficiency and excellent biocompatibility, and can be used to prepare drugs for the treatment of intracerebral hemorrhage and secondary neurological injury, with good prospects for clinical translation.

The invention discloses a brain multi-modal image data processing method and device. The method comprises the steps of obtaining a brain multi-modal image sequence of a target object; fusing the three-dimensional contrast-agent-free angiography with the plaque internal hemorrhage image sequence and the time leap method imaging image sequence to obtain cerebrovascular image data; cerebrovascular image data is used as a tree root node and a trunk node, hemodynamic parameter data in a phase contrast angiography sequence is used as a branch node for representing a blood supply state, and neural structure parameter data in a diffusion magnetic resonance imaging sequence is used as a branch node for representing a neural structure. Physical and chemical parameter data in the liquid attenuation inversion recovery sequence are used as leaf nodes for representing functional metabolism, hemodynamic parameter data in the magnetic resonance brain perfusion imaging sequence are refined to a pixel level and then are used as leaf nodes for representing metabolic activity, and a brain biological characteristic tree of the target object is constructed. According to the method, the brain multi-modal image data can be quantitatively analyzed.

A wearable monitor is configured for early detection of internal bleeding events and particularly hematomas after vascular catheterization including cardiac catheterization. The wearable monitor is placed over an access location following the vascular catheterization procedure and the wearable monitor system periodically runs diagnostic test to detect changes in the tissue around the vascular access location. An emitter device may input an emitter input into the tissue and a detector device may then measure the emitter input after it has passed through the tissue, an emitter output. A computer may receive the data from the detector device and operate a program that determines changes in the tissue and in particular, pooling of blood in the tissue. The emitters may be electrodes that input an electromagnetic input, or an ultrasound emitter that inputs ultrasound sound waves, or a Near IR emitter that emits Near IR electromagnetic radiation.

The present invention provides a novel method to isolate and expand pure neural stem cells (NSCs) from cerebrospinal fluid (CSF) of premature babies with Intraventricular haemorrhage, which produces a population enriched in NSC-CSF cells free of contaminating fibroblasts and other cell types. The present invention also includes substantially pure populations of CSF-NSC cells, and their use to treat and prevent diseases and injuries, including Intraventricular haemorrhage and post- hemorrhage hydrocephalus / developmental deficits.

An ultrasound catheter with a lumen for fluid delivery and fluid evacuation, and an ultrasound source is used for the treatment of intracerebral or intraventricular hemorrhages. After the catheter is inserted into a blood clot, a lytic drug can be delivered to the blood clot via the lumen while applying ultrasonic energy to the treatment site. As the blood clot is dissolved, the liquefied blood clot can be removed by evacuation through the lumen.

The utility model discloses an intracranial hemorrhage detection experimental device, which comprises a suspension unit, a laser emission unit, a phantom placement unit and a photoelectric detection unit, adopts a multilayer mixed craniocerebral phantom, and solves the problems that a solid phantom cannot simulate the dynamic change of the craniocerebral and a liquid phantom cannot reflect the multilayer structure of the craniocerebral. The detection accuracy is demonstrated by using a phantom experiment, and the method can be repeated and reproduced. The device can be flexibly adjusted, and the simulation requirements of different crowds are met.

A system for treating internal bleeding via application of a heated irrigant, such that the heated irrigant is delivered at a flow rate of between 2 cc / s and 12 cc / s and at a temperature of between 46 degrees Celsius and 52 degrees Celsius.

The embodiment of the invention provides a cerebrospinal fluid venous imbedding drainage device and an operation method thereof, and relates to the field of medical instruments. The cerebrospinal fluid venous imbedding drainage device comprises a drainage pump body, a ventricular drainage tube and a venous catheter. In the operation process, a power source can be provided by the drainage pump body, so that cerebrospinal fluid accumulated in the ventricle can be led out through the ventricle drainage tube and led into veins through the venous catheter for metabolism, and then the effects of treating cerebrospinal fluid accumulation, intracranial pressure rise, cognitive function decline and senile dementia caused by cerebrospinal fluid lesion are achieved. The traditional Chinese medicine composition can treat and improve the problems of intracranial hemorrhage, subarachnoid hemorrhage, other intracranial non-infectious inflammatory metabolites, immune complexes, intracranial hemorrhage, subarachnoid hemorrhage and the like, so that the traditional Chinese medicine composition can be used for treating long-term and repeated illness conditions, and the treatment effect is improved.

The invention discloses application of a BDNF / TrkB / PI3K / AKT pathway promoter as a medicine for relieving nerve injury of a mouse with intracranial hemorrhage. According to the application, the neurological function and the muscle force function can be improved 7 days after cerebral hemorrhage, and the spatial learning and memory functions after cerebral hemorrhage can be improved.

The invention discloses an intracranial hemorrhage CT image segmentation method and device, a medium and equipment, and relates to the technical field of image segmentation. In a segmentation threshold optimization process, a Bareones mechanism and an orthogonal learning mechanism are integrated into an African vulture optimization algorithm, a search space is expanded in a search population corresponding to a segmentation threshold through Gaussian mutation, and the ability of the threshold optimization algorithm to get rid of local optimum is enhanced; and an orthogonal learning mechanism promotes resource sharing among search population individuals corresponding to the segmentation threshold, and improves the search diversity of the segmentation threshold. And obtaining an optimal individual with the maximum Renyi entropy after the two-dimensional histogram is divided based on the threshold value through multi-round iterative optimization, and taking the optimal individual as an optimal segmentation threshold value of the intracranial hemorrhage CT image. According to the method, the population diversity and convergence speed in segmentation threshold optimization of the intracranial hemorrhage CT image are improved, and the image segmentation effect of the intracranial hemorrhage CT image is improved.

The application relates to the technical field of medical devices, in particular to a portable intraperitoneal hemorrhage qualitative detector, which comprises a detection control instrument, a detector is arranged on the front side of the detection control instrument, the detector comprises a detection assembly, a taking assembly is arranged on the top of the detection assembly; the detection assembly comprises a control assembly, a coupling agent smearing assembly is fixedly connected to the rear side of the control assembly. The detection control instrument and the detector are arranged, rapid and accurate qualitative detection of intraperitoneal hemorrhage is realized, the whole detection process has high automation degree, operation is simple, the detector has reasonable structure design, all components work cooperatively, after the electric push rod is started, a series of actions such as coupling agent smearing, detection head close to the detection position, qualitative detection, automatic resetting of all components after the detection is completed and the like can be sequentially completed, the detection efficiency is greatly improved, and the detection head is shielded after resetting, so that pollution or damage of the detection head due to exposure is effectively avoided.

The present invention provides a multi-purpose first-aid device for emergency hemostasis, drainage and abdominal cavity expansion in the abdominal cavity, comprising: a penetrating part, the bottom of which can penetrate into the interior of the abdominal cavity through an abdominal wall incision of a patient, and the top of which is located outside the abdominal cavity and is provided with a lifting part; a hemostasis and drainage mechanism, which is slidably penetrated through the penetrating part and is used for pressing and hemostasis at the bleeding position in the abdominal cavity and performing abdominal cavity drainage; and an expansion mechanism, which comprises a lifting plate and a driving assembly, the lifting plate is rotatably installed on one side of the bottom of the penetrating part, and the driving assembly is used for driving the lifting plate to rotate so that the lifting plate can be turned outwards or inwards. The present invention coordinates the operations of hemostasis, drainage and abdominal cavity expansion in the abdominal cavity, so that the operations of abdominal cavity hemostasis, drainage and abdominal cavity expansion can complement each other and interact with each other, greatly shortening the operation interval between multiple operations and winning precious time for the treatment of patients.

The invention relates to the field of biological medicines, in particular to application of fullerene and fullerene derivatives in preparation of medicines, and the medicines are used for preventing, relieving, assisting in treating or treating intracranial hemorrhagic diseases. The invention finds that the fullerene and the fullerene derivative have excellent blood brain barrier crossing capability, can remarkably reduce neurotoxicity caused by intracranial hemorrhagic diseases such as cerebral hemorrhage and accelerate hematoma absorption, can be used for preparing medicines for preventing, relieving, assisting in treating or treating the intracranial hemorrhagic diseases, and has a wide application prospect. A new strategy and a solution scheme are provided for treatment of related diseases such as intracranial hemorrhagic diseases, and the application prospect is wide.

The embodiment of the invention provides a fundus image hemorrhage identification method and device, electronic equipment and a storage medium, and relates to the technical field of fundus image processing, and the method comprises the steps: obtaining a fundus image, and carrying out the preprocessing of the fundus image; extracting a bleeding area and a blood vessel area of the fundus image; calculating feature information of bleeding points in the bleeding area; wherein the feature information comprises hemorrhagic spot area, hemorrhagic spot number and hemorrhagic spot position; analyzing to obtain a fundus hemorrhage depth result according to the position relationship between the hemorrhage point and the blood vessel region; wherein the fundus hemorrhage depth result comprises one or more of intraretinal hemorrhage, supraretinal hemorrhage and subretinal hemorrhage; the fundus image is automatically processed and analyzed, the fundus hemorrhage position is obtained, the recognition precision and the recognition effect are improved, the risks of misdiagnosis and missed diagnosis are reduced, and therefore the diagnosis accuracy is improved.

A method for supporting diagnosis of intraventricular hemorrhage and early death within a week in very low birth weight infants based on deep learning includes a data collection step, a data preprocessing step, a learning step of training a prenatal prediction model, training a birth prediction model and training a postnatal prediction model, and a diagnosis step of, when a diagnosis target and diagnosis time are determined, selecting one prediction model based on the diagnosis time, analyzing medical information of the diagnosis target through the selected prediction model, and predicting and outputting the intraventricular hemorrhage diagnosis result.

Disclosed herein are resuscitation fluids and compositions comprising NEFA free blood serum albumin and hemoglobulin (cell free or as lysed red blood cells) and methods of treating internal bleeding and hemorrhage.

The invention relates to the technical field of medical image processing, in particular to an unsupervised fetal cerebral hemorrhage detection and focus segmentation method and device and electronic equipment, and the method comprises the steps: obtaining the magnetic resonance imaging data of a normal fetal brain; the method comprises the following steps: synthesizing a plurality of pseudo fetal focus and intraventricular hemorrhage images from magnetic resonance imaging data of a normal fetal brain by using medical priori knowledge, and generating training data according to the plurality of pseudo fetal focus and intraventricular hemorrhage images; training a segmentation model by using the training data, inputting the magnetic resonance imaging data of the brain of the target fetus into the trained segmentation model, and outputting a segmentation result of the focus of the brain of the target fetus and the intraventricular hemorrhage by the segmentation model. Therefore, the problems that in the prior art, training data is scarce, and a large amount of manual annotation data needs to be relied on for model training are solved.

The application discloses an intracranial hemorrhage CT image segmentation method and device, medium and equipment, and relates to the technical field of image segmentation. In the threshold segmentation optimization process, the Barebones mechanism and the orthogonal learning mechanism are integrated into the African vulture optimization algorithm. The search space is expanded in the search population corresponding to the segmentation threshold through Gaussian mutation, and the ability of the threshold optimization algorithm to get rid of local optimization is enhanced. The orthogonal learning mechanism promotes the resource sharing between the search population individuals corresponding to the segmentation threshold, and improves the search diversity of the segmentation threshold. Through multiple rounds of iteration optimization, the optimal individual that makes the Rényi entropy of the two-dimensional histogram based on the threshold segmentation maximum is obtained as the optimal segmentation threshold of the intracranial hemorrhage CT image. The application improves the population diversity and convergence speed in the threshold segmentation optimization of the intracranial hemorrhage CT image, and improves the image segmentation effect of the intracranial hemorrhage CT image.

The present invention provides a method for detecting internal bleeding based on near-infrared spectroscopy, comprising the following steps: Step 1, dividing a plurality of scanning areas according to the composition of the human body's torso, and scanning each scanning area of ​​the injured person using a near-infrared spectrometer; Step 2, using a photodetector to detect scattered light signals emitted from human tissue in real time, and calculating the light absorbance of the human tissue during the scanning process based on the scattered light signals; Step 3, comparing the light absorbance during scanning within the same scanning area to determine whether a blood clot exists and mark the blood clot boundary; Step 4, repeatedly scanning in multiple directions around the blood clot boundary, sequentially comparing the light absorbance during the scanning process, and determining the entire boundary of the blood clot; Step 5, determining the blood clot size and bleeding location based on the entire boundary of the blood clot. The method for detecting internal bleeding based on near-infrared spectroscopy provided by the present invention can effectively assess the location of bleeding in the body.

Embodiments of the present application relate to the technical field of brain hemorrhage detection, and particularly relate to a method for determining brain microwave signal imaging, a system thereof, an intracranial hemorrhage detection device and a computer storage medium. The method for determining brain microwave signal imaging according to the embodiments of the present application comprises the following steps: obtaining brain microwave signals; filtering out clutter of the microwave signals to obtain only brain microwave signals; and determining brain signal imaging according to the obtained only brain microwave signals. The method provided by the embodiments of the present application can more clearly display the position of the hemorrhage area in the brain due to fewer clutter points of pixels in the brain imaging.