2260 results about "Mucous membrane" patented technology

The invention relates to the technical field of oral medical treatment, in particular to an oral disease analysis method and system based on AI intelligent recognition. Comprising the following steps that oral cavity three-dimensional surface data are obtained through an oral scanning module integrated with a dental chair, and the oral scanning module adopts a structured light coding and multi-view fusion algorithm; an oral soft tissue high-definition image is collected through an endoscope module, and an AI analysis unit is arranged in an endoscope to recognize mucous membrane lesion features in real time; calling CBCT image data of the patient, and aligning a three-dimensional image with oral scanning data through a spatial registration algorithm; the mouth scanning data, the endoscope image and the CBCT data are subjected to multi-modal fusion by adopting a dynamic weight fusion mechanism. According to the scheme, the problem of accurate registration of cross-modal data, the lack of a dynamic quality evaluation mechanism of heterogeneous data and the real-time collaboration bottleneck of dispersed equipment can be solved.

A surgical anchor device for being anchored on the mucous membrane of the inner wall of the intestine, the device having a temporary anchor element presenting anchoring that can be modified in a controlled manner and having a first substantially cylindrical multiply-perforated wall presenting properties of radial elasticity whereby the first wall presents an outer diameter that can be varied in controlled manner, wherein a portion of the inner surface of the first wall is lined with an independent leakproof inner sheath having only its longitudinal ends fastened to the anchor element to define a suction chamber between the inner sheath and the first wall, the temporary anchor element being coupled to a flexible or semi-rigid tube extending outside the anchor element, an open end of the injection-suction tube opening out into the suction chamber enabling air to be injected into or sucked out from the suction chamber.

The invention relates to an intelligent endoscope image evaluation method for ulcerative colitis, and the method comprises the steps: synchronously collecting video streams and three-dimensional point cloud data of a colonic mucosa through an endoscope system equipped with a structured light depth sensor, and constructing a three-dimensional coordinate system based on a colon anatomy trend; based on the three-dimensional point cloud data, constructing a complex topological structure on the surface of the colonic mucosa, and calculating a continuous homology feature set of the lesion area; and based on the persistent homology feature set, constructing a multi-scale graph neural network model of ulcerative colitis and Crohn disease specificity. By implementing the scheme, the structural and topological modeling of the colon mucosa lesion area can be realized, and the morphological characteristic difference between ulcerative colitis and Crohn's disease can be effectively captured. The multi-scale graph neural network fuses macroanatomical segmentation and micropathology features, efficient distinguishing of continuous and jumping lesions is achieved, finally, an intelligent and visual endoscope evaluation report is generated, and the accuracy and real-time performance of auxiliary diagnosis in an operation are improved.

The invention discloses a cyclic hexapeptide for skin care and a composition and application thereof, and relates to the technical field of polypeptides, and the cyclic peptide has the following structure: Cyclo-[Arg-Arg-Gln-D-Met-Glu-Glu]. Specifically, the invention relates to the cyclic peptide or the salt thereof, or a composition of the cyclic peptide and the salt thereof, and application of the cyclic peptide and the salt in preparation of a composition for nursing or treating skin or mucosa.

The invention provides a composition capable of penetrating an intestinal barrier by oral administration. The composition contains a carrier or an auxiliary material of a targeted Microflod cell Dectin-1 receptor, and one or / and a plurality of medicinal components / components, wherein the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan, and the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan. The effective components / components are traditional Chinese medicine effective components / components, or / and probiotics, or / and chemical medicine components, or / and biological medicines. The invention relates to a composition capable of realizing oral administration and penetrating through an intestinal barrier, which is based on the discovery of the inventor that the composition reaches colon through gastrointestinal tracts, targets colon Microflood cells, is taken by the Microflood cells, penetrates through the intestinal barrier and enters immune tissue Colonic Patches of a colon submucosa. Based on the research, the composition disclosed by the invention can be used for treating various diseases, such as ulcerative colitis, Crohn's disease, colon cancer, rheumatoid arthritis or bacterial pneumonia after being orally taken and absorbed by rectum.

The invention discloses an endoscopic mucous membrane incision knife capable of upheaving a groveling tissue, relates to the technical field of surgical instruments, and can solve the problem that in a mucous membrane dissection operation, after a part of tissue is dissected by using one instrument, the residual small part of tissue can not be effectively upheaved after groveling. The mucous membrane incision knife used for the endoscope and capable of protruding the lower prone tissue comprises a double-channel sheathing canal provided with a first channel and a second channel, a cutting assembly arranged in the first channel and the second channel respectively, and a pushing assembly used for pushing the lower prone tissue to protrude. Wherein the pushing assembly comprises a pushing soft strip capable of being bent and deformed and a pushing end fixed to the end of the pushing soft strip, and the pushing soft strip is located in the second channel and can stretch out of the second channel; and when the pushing soft strip extends out of the second channel, an included angle is formed between the pushing soft strip and the cutting assembly.

The invention provides an insertion part, an endoscope and a suction system, and relates to the technical field of endoscopes, the insertion part comprises a tube body, the tube body is provided with a first fluid channel, and the tube body is used for being inserted into a sheathing canal; the second fluid channel is arranged in the axial direction of the tube body, a far port of the second fluid channel is adjacent to a far port of the first fluid channel, and a near port of the second fluid channel is used for being communicated with a sheath tube; the driving part is connected with the second fluid channel and used for driving the second fluid channel to deform in the radial direction of the tube body, and therefore the radial size and the corresponding section flow area of the second fluid channel are adjusted. Friction between the outer wall of the ureter and the inner wall of the ureter can be effectively reduced, mucous membranes are prevented from being pressed or torn, and therefore the risk of postoperative bleeding, infection and the like is reduced.

The invention relates to digestive tract mucosa protective agent powder as well as a preparation method and application thereof, and the digestive tract mucosa protective agent powder contains gel and a cross-linking agent, the gel comprises any one or a combination of at least two of cellulose, modified cellulose, alginate, modified alginate, sodium polyglutamate, modified sodium polyglutamate, starch, modified starch, sodium hyaluronate, modified sodium hyaluronate, pectin or modified pectin, and the cross-linking agent comprises an ionic cross-linking agent or a nonionic cross-linking agent. The powder protective agent provided by the invention is convenient to produce and simple to use, can be adhered to the surface of a mucous membrane wound surface only through simple spraying operation, forms a hydrogel protective layer under the action of gastric juice, intestinal juice or other liquid on the surface of the wound surface, plays a role of a physical barrier, and has a good application prospect. The continuous erosion of digestible liquid or pathogenic microorganisms on the surface of the wound surface to the wound surface is effectively blocked.

The magnetic traction tool comprises an endoscope device and a traction device, the traction device is clamped at one end of the endoscope device, the traction device is composed of a rubber ring and a magnetic ring, the traction device is composed of a shell and a magnet, and the magnet is connected with the shell through an adjusting mechanism. The endoscope device is adopted for feeding the traction device, the periphery of the mucous membrane is fixed through the traction device, mucous membrane traction is conducted through the traction device on the outside, the mucous membrane on the periphery of a focus is stripped through magnetic traction, the operation convenience is effectively improved, and the problem that mucous membrane resection is inconvenient due to the narrow operation area is solved; the operation difficulty is effectively reduced, when the magnet ring is attracted through the magnet, magnetic force adjustment can be achieved through the adjusting mechanism, adjustment can be conducted according to the distance of the traction position, it is guaranteed that traction is in place so that smooth stripping of the mucous membrane can be guaranteed, magnetic traction stripping can not be limited by the traction direction, and mucous membrane resection convenience is guaranteed.

The invention provides a modified small intestinal submucosa which is a small intestinal submucosa grafted by methacrylic anhydride, and the grafting rate of the methacrylic anhydride is 40-90%. After cross-linking and curing, the modified small intestinal submucosa material provided by the invention has excellent biocompatibility, degradability and mechanical properties, can effectively promote revascularization and regulate immunoreaction, and has a wide application prospect as a tissue repair material.

The invention discloses a normal-temperature bacteria liquid enteric-coated targeted colonization microcapsule and a preparation method thereof. The invention belongs to the technical field of biological medicine. The structure of the room-temperature bacterial liquid protection microcapsule is as follows: an inner layer is an activity maintaining layer and mainly consists of a sodium alginate-calcium chloride polyelectrolyte compound (the thickness is 50-100 microns); the middle layer is a pH response release layer and is mainly composed of hydroxypropyl methyl cellulose phthalate (HPMCP, dissolved at pH of 6.8 or above) and nano calcium carbonate particles (the particle size is 50nm, and the proportion is 10% w / w); the outer layer is a mucous membrane adhesion layer, and the main components of the mucous membrane adhesion layer comprise fucose modified chitosan (Fuc-CS, targeted colonic mucous membrane lectin protein) and carbomer 940 (pH sensitive adhesion polymer); the method is a microcapsule capable of preserving the bacterial liquid at normal temperature and accurately targeting colon release and adhesion colonization and a process thereof, the problem of flora activity loss caused by a freeze-drying process can be solved, in addition, the process does not need freeze-drying equipment, and the production cost is reduced.

The invention discloses an external traditional Chinese medicine mixture aiming at genital skin mucosa ulceration wound repair and a preparation method thereof, relates to the field of traditional Chinese medicines, and aims to provide a genital skin mucosa ulceration wound repair medicine which has the effects of promoting wound repair and relieving itching, and is simple in component, small in allergy probability, light and thin in dosage form and good in skin feeling. The traditional Chinese medicine mixture is prepared from chicken butter, honeysuckle stem, felwort, cortex dictamni, fructus kochiae, radix scutellariae, cortex phellodendri, angelica sinensis, radix rehmanniae, radix arnebiae seu lithospermi, sanguisorba officinalis and bletilla striata. The traditional Chinese medicine mixture disclosed by the invention realizes simultaneous treatment of pruritus vulvae and ulceration, fills the treatment blank, relieves symptoms as soon as possible, shortens the treatment cycle and saves expenditure. The curative effect is prominent, and current clinical requirements are met. Cost and loss are reduced. Preparation is convenient, high-end machines are not needed, and preparation can be carried out at home.

The invention relates to the technical field of medical materials, in particular to an injection composition for endoscopic submucosal dissection and a preparation method and application thereof. The injection composition is prepared from the following raw materials: 1 to 5 w / v percent of sodium hydroxymethyl starch, 0.1 to 10 w / v percent of acetylcysteine, 0.2 to 4 w / v percent of polyvinylpyrrolidone, 0.001 to 0.1 w / v percent of coloring agent and the balance of phosphate buffer solution. The injection composition disclosed by the invention can be directly injected under mucous membranes, plays a role in upheaving diseased regions, has the advantages of long maintenance time and high upheaving degree, and has the effects of stopping bleeding and promoting wound healing.

The invention provides a duodenal mucosa adjusting system and method based on pulsed electric field ablation and application of the duodenal mucosa adjusting system and method in diabetes treatment, the duodenal mucosa adjusting system comprises an intelligent control host capable of achieving bidirectional data transmission and an adjustable catheter, and the intelligent control host initializes parameters and adjusts pulse parameters by monitoring impedance data in real time until pulses are interrupted or terminated; periodic ablation is carried out, periodic intervals are used for measuring impedance data, the ablation depth is evaluated according to the impedance change rate, and whether next section ablation is carried out or not is judged till full-area ablation is completed. The far-end ablation adopts a structure of combining fusiform flexible support and annular electrode spiral arrangement to ensure that an ablation field uniformly covers mucous membrane plica of a duodenum bulb part and a descending part; a cell selective ablation mechanism is adopted, the critical electric field intensity is set, K cell electroporation is selectively induced, and meanwhile goblet cells are protected.

The invention relates to the technical field of RT type lacrimal passage drainage tube application, and particularly discloses an RT tube application method for simultaneously solving upper and lower lacrimal passage blockage, which comprises the following steps of: firstly, performing preoperative local anesthesia on a patient; the upper lacrimal punctum and the lower lacrimal punctum of the diseased eye are expanded, and after a thin probe is used for probing the obstruction position of the lacrimal passage from the upper lacrimal ductule and the lower lacrimal ductule, the lacrimal passage is flushed Expanding the obstructed part of the lacrimal passage by using a large probe; then, the artificial lacrimal duct is implanted, the RT tube is implanted into the upper and lower lacrimal ducts at the same time, the problem of blockage of multiple parts is solved through a single instrument, repeated damage to periorbital tissue caused by fractional operations is avoided, and the device is particularly suitable for complex cases that upper and lower lacrimal canalicules and nasolacrimal ducts are blocked or narrow at the same time; the whole-course drainage of the tears from the upper and lower lacrimal passages to the nasal cavity is further ensured, and the physiological path of tear circulation is recovered; the RT tube is placed, skin or mucous membrane does not need to be cut open, no scar is visible after operation, and the requirement for periocular beauty is met.

The invention discloses a non-endoscope-mediated locatable instant esophageal mucosa impedance detection system which comprises a catheter assembly, and a real-time mucosa impedance detection module, a real-time pressure monitoring module, a real-time pH monitoring module, a signal processing module and a high-resolution signal display module which are mounted on the catheter assembly, the catheter assembly is inserted into the esophagus through the nasal cavity, and in the insertion process, whether the catheter assembly is inserted into a preset position or not is judged through the real-time pressure monitoring module and the real-time pH monitoring module. According to the non-endoscope-mediated locatable instant esophageal mucosa impedance detection system disclosed by the invention, linkage is carried out through the catheter assembly, the real-time mucosa impedance detection module, the real-time pressure monitoring module, the real-time pH monitoring module, the signal processing module and the high-resolution signal display module, endoscope mediation and anesthesia are not needed, and the real-time pressure monitoring module, the real-time pH monitoring module, the signal processing module and the high-resolution signal display module are linked; the esophageal mucosa impedance value and the esophageal pH value can be detected in real time, and a basis is provided for diagnosing the gastroesophageal reflux disease.

The invention discloses an oral care composition and a preparation method thereof, the oral care composition comprises a friction agent, a periodontal repair agent, a thickening agent, a humectant and a foaming agent, the friction agent comprises a dental plaque release agent, and the dental plaque release agent is configured to destroy a bacterial extracellular polysaccharide matrix in dental plaque; the periodontal repair agent comprises at least one of the following components: an inflammation inhibitor, a tissue repair promoter, a mucous membrane stimulation alleviator and a bacteriostatic agent. The oral care composition contains the dental plaque release agent and the periodontal repair agent, and can synergistically improve periodontal health.

The invention relates to the technical field of tissue isolation, and particularly discloses a high-activity intestinal crypt and an isolation method and application thereof. The separation method comprises the following steps: S1, taking fresh intestinal tracts, cleaning contents, and scraping mucous membrane layer tissues to obtain intestinal mucous membrane tissues; s2, shearing intestinal mucosa layer tissues, mixing the intestinal mucosa layer tissues with the separation liquid after cleaning, and digesting and dissociating to obtain intestinal mucosa tissue digestive juice; s3, centrifuging the intestinal mucosa tissue digestive juice, removing supernate, mixing the supernate with the protective liquid to obtain intestinal crypt mixed liquid, filtering, centrifuging, and taking precipitate to obtain high-activity intestinal crypts; wherein the separation liquid comprises collagenase I, collagenase II, collagenase IV, elastase, DNA enzyme I and a ROCK inhibitor; the protection liquid comprises an RPMI1640 culture medium, antibiotics, fetal calf serum, bovine serum albumin and a ROCK inhibitor. The technical scheme provided by the invention aims to shorten the intestinal tract crypt separation time and improve the cell viability.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, those within the respiratory tract, particularly the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The systems may be used to treat pathogens, such as bacteria and viruses, particularly coronaviruses.

The invention relates to the technical field of medical auxiliary instruments, and discloses a nasal cavity dilatation stent and an implantation tool thereof. According to the nasal cavity dilatation support and the implanting tool thereof, the inflatable air bag is connected with the inflatable tube of the elastic air bag layer through the connecting tube and is matched with the one-way valve in the middle, step-by-step inflation can be achieved, the dilatation degree can be conveniently adjusted according to needs, gas backflow can be prevented, and the elastic air bag layer at the outer end of the nasal cavity dilatation sleeve achieves nasal cavity dilatation through inflation expansion. Compared with point contact of a traditional rigid metal dilator, the air bag layer and the nasal cavity wall form surface contact, the contact pressure intensity is reduced, and the mucous membrane compression injury rate is synchronously reduced; meanwhile, the elastic characteristic of the air bag can adapt to individual differences of nasal cavities of different patients, instruments of different specifications do not need to be replaced, medical staff can operate an elastic clamp with one hand to clamp the two nasal cavity dilatation sleeves to be stuffed into the two nasal cavities of the patients through arrangement of the implantation assembly, use is rapid and convenient, and the practicability is high. And the practicability of the nasal cavity dilatation stent and the implanting tool thereof is improved.

The invention relates to the technical field of biotechnology, and discloses a special biological fresh-keeping preservative method for cattle stomach, which comprises the following steps: firstly, pretreating the cattle stomach; the method comprises the following steps: putting the cattle stomach into flowing clear water, washing off obvious impurities, dirt and mucous membrane liquid on the surface, soaking the cattle stomach in saline water or a food-grade cleaning agent solution in a certain proportion for 10-30 minutes, kneading the surface of the cattle stomach, washing the kneaded cattle stomach with clear water again, and removing impurities and cleaning agent residues after soaking and kneading, and placing the cleaned cattle stomach in a filter screen or a clean container, and naturally draining water. And further determining the strain by adopting a 16SrDNA (Deoxyribose Nucleic Acid) detection technology, and analyzing experimental data to find out a bacteriostatic agent with the best effect and the lowest effective bacteriostatic concentration through a bacteriostatic activity experiment. And finally, determining quality index data of the cattle stomach through a single factor and an orthogonal test, and optimizing the bacteriostatic agent with the best effect, so that the shelf life of the cattle stomach stored at low temperature is prolonged.

The invention discloses an image processing method and device based on image signals with different central wavelengths, equipment, a medium and a product, and relates to the technical field of image processing.The method comprises the steps that a first image signal, a second image signal and a third image signal obtained by irradiating a target area with illumination light with three sequentially-increased central wavelengths are collected; calculating spectral information of the target area image according to the three image signals; filtering the spectral information to obtain a target image signal; extracting a pixel region higher than a first threshold value from a difference image of the second image signal and the first image signal as a middle-layer blood vessel and mucous membrane region; extracting a pixel region higher than a second threshold from a difference image of the third and second image signals as a deep blood vessel and blood accumulation region; and carrying out brightness improvement on the target image signal by using the two extracted regions, and taking the target image signal after brightness improvement as a G channel of an output image. The image processing cost for highlighting the bleeding point can be reduced.

The sputum suction equipment comprises a main body box, the driving assembly is mounted in the main body box, and the output end of the driving assembly extends out of the main body box; the sputum suction assembly is mounted at the output end of the driving assembly; the double-layer film is mounted at the suction end of the sputum suction assembly; according to the technical scheme, the driving assembly is adopted to drive the sputum suction assembly to rotate, the rotating spiral back suction head makes uniform contact with the oral cavity of a patient, and mucosa damage caused by single-point repeated friction is avoided; and stubborn sputum scab and thick sputum can be cleaned through rotation of the spiral back-suction head, the spiral groove guides the sputum to gather towards the head of the spiral back-suction head, side wall adsorption is reduced, more sputum can be conveniently sucked into the spiral back-suction head, and more efficient sputum suction is achieved.

The invention relates to the technical field of medical image processing, in particular to an enterostomy mucous membrane state evaluation system based on color comparison, which comprises a multi-modal data acquisition module used for acquiring and analyzing a mucous membrane image sequence, ambient light characteristics and basic physiological data and generating acquisition data records with aligned timestamps; and the individualized benchmark modeling module is used for establishing a patient specific color reference benchmark through HSL color space analysis on the basis of the collected data records and the preoperative physiological indexes, and generating an initial adaptive color gamut threshold model. According to the method, the specific initial color reference is established for each patient, and the sliding window algorithm is combined to continuously monitor the color gamut drift so as to dynamically update the reference, so that accurate self-adaption to individual physiological differences of the patients and postoperative slow recovery changes is realized, and therefore, the objectivity and accuracy of evaluation are greatly improved; the problem of misjudgment caused by individual differences or normal evolution of physiological states in a traditional fixed threshold value method is effectively avoided.

A detachable multi-loop traction device for insertion into a body through a forceps tube of an endoscope, in which when a diseased mucous membrane in the body is resected by an extracorporeal operation, the traction device is provided with a plurality of loops for traction of the diseased mucous membrane. The detachable multi-ring traction device is configured to be fixed to the lesion mucous membrane and a normal mucous membrane opposite to the lesion mucous membrane through clamps. The detachable multi-ring traction device is provided with a plurality of annular rings having a large circle and a small circle, and two adjacent rings are connected with each other in a manner of being connected with each other in the diameter direction of the large circle in a state that outer edge parts of the two adjacent rings are connected with each other.

According to the endoscope imaging fusion enhanced imaging method and device, imaging characteristics of white light (an overall structure background), red light (a deep blood vessel), green light (a high-contrast capillary vessel) and blue light (an enhanced surface microstructure) are comprehensively utilized, digestive tract mucosa can be analyzed in a layered mode, and comprehensive diagnosis and early focus recognition from the surface layer to the deep layer are achieved; during image fusion, adaptive weight configuration based on focus types is supported by adopting a weight dynamic adjustment mechanism, so that the quality of the finally fused image is influenced, and therefore, a neural network architecture is adopted to train each channel weight, and a more reasonable weight value can be obtained.

According to the double-end needle and thread suturing device, suturing needles can be alternately locked on two clamping bases, so that the suturing needles drive suturing threads to penetrate through human mucous membrane tissues, and the suturing needles penetrate through the human mucous membrane tissues for multiple times by repeating multiple operations, so that the purpose of suturing the human mucous membrane tissues is achieved. When the suture needle is used, only the two ends of the suture needle need to be fixed, a complex fixing structure and a complex driving structure are not needed, and therefore the complexity of a product is reduced, the error-tolerant rate of the suture needle in the suture process is increased, the operation difficulty of the product is reduced, and the product is easier to operate.

The invention discloses a digital stable jaw pad designing and manufacturing method, and relates to the technical field of oral rehabilitation and digital medical technology.The digital stable jaw pad manufacturing method comprises the following steps that a, three-dimensional point cloud data of oral dentition and mucosa of a patient is obtained through a three-dimensional scanner; b) determining a stable jaw position coordinate model by using an optical motion capture system; c) designing a jaw pad three-dimensional entity model with an anterior tooth area, a posterior tooth area and an edge structure based on the three-dimensional point cloud data and the stable jaw coordinate model; and d) manufacturing the jaw pad through 3D printing equipment, wherein the 3D printing equipment is formed by adopting a polyether-ether-ketone material. By integrating digital acquisition, design and manufacturing technologies, the pain point of a traditional method is solved, and personalized, high-precision and rapid manufacturing of the stable jaw pad is realized.

The invention provides an application of a lactobacillus paracasei IOB413 metagen in prevention of helicobacter pylori infection, and relates to the technical field of microorganisms. The lactobacillus paracasei IOB413 metaplasm can competitively occupy gastric epithelial cell adhesion sites to directly block the initial colonization of helicobacter pylori, so that infection preposed interception is realized, and the lactobacillus paracasei IOB413 metaplasm is suitable for early prevention of high-incidence people. The compound has dual mechanisms of site blocking and urease inhibition, and can cooperate with antibiotics to improve the eradication rate and reduce the drug resistance. Animal experiments show that the traditional Chinese medicine composition can reduce gastric mucosa proinflammatory factors in a dose-dependent manner, improve the activity of antioxidant enzymes, reduce lipid peroxidation products, relieve mucosa lesion, promote repair and reduce the risk of complications; moreover, gastrointestinal hormone disorder can be reversed, the digestive function is maintained, and related discomfort is relieved.

The invention belongs to the technical field of biological materials, and particularly relates to a conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity and a preparation method of the conductive hydrogel microneedle patch. The preparation method comprises the following steps: firstly, loading plant essential oil with antibacterial and anti-inflammatory activity on mesoporous polypyrrole nanoparticles to prepare drug-loaded nanoparticles, then preparing a pre-hydrogel mixture containing the drug-loaded nanoparticles, and then filling the mixture into a PDMS microneedle mold to obtain the conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity. The prepared microneedle patch not only has excellent antibacterial and anti-inflammatory activity and a conductive function, but also has the characteristics of a microneedle and hydrogel, and can deliver a drug to a skin cuticle or a lower layer of a bacterial biofilm, so that the bioavailability of transdermal drug delivery of the drug is greatly improved. Besides, the microneedle patch is swelled after absorbing tissue exudate, is adhered to the surface of skin or other mucous membranes to continuously play antibacterial and anti-inflammatory roles and conductive functions, and provides wet healing conditions, so that high-quality healing of skin wounds is accelerated.