1688 results about "Mucous membrane" patented technology

The invention relates to the technical field of oral medical treatment, in particular to an oral disease analysis method and system based on AI intelligent recognition. Comprising the following steps that oral cavity three-dimensional surface data are obtained through an oral scanning module integrated with a dental chair, and the oral scanning module adopts a structured light coding and multi-view fusion algorithm; an oral soft tissue high-definition image is collected through an endoscope module, and an AI analysis unit is arranged in an endoscope to recognize mucous membrane lesion features in real time; calling CBCT image data of the patient, and aligning a three-dimensional image with oral scanning data through a spatial registration algorithm; the mouth scanning data, the endoscope image and the CBCT data are subjected to multi-modal fusion by adopting a dynamic weight fusion mechanism. According to the scheme, the problem of accurate registration of cross-modal data, the lack of a dynamic quality evaluation mechanism of heterogeneous data and the real-time collaboration bottleneck of dispersed equipment can be solved.

A surgical anchor device for being anchored on the mucous membrane of the inner wall of the intestine, the device having a temporary anchor element presenting anchoring that can be modified in a controlled manner and having a first substantially cylindrical multiply-perforated wall presenting properties of radial elasticity whereby the first wall presents an outer diameter that can be varied in controlled manner, wherein a portion of the inner surface of the first wall is lined with an independent leakproof inner sheath having only its longitudinal ends fastened to the anchor element to define a suction chamber between the inner sheath and the first wall, the temporary anchor element being coupled to a flexible or semi-rigid tube extending outside the anchor element, an open end of the injection-suction tube opening out into the suction chamber enabling air to be injected into or sucked out from the suction chamber.

The invention relates to an intelligent endoscope image evaluation method for ulcerative colitis, and the method comprises the steps: synchronously collecting video streams and three-dimensional point cloud data of a colonic mucosa through an endoscope system equipped with a structured light depth sensor, and constructing a three-dimensional coordinate system based on a colon anatomy trend; based on the three-dimensional point cloud data, constructing a complex topological structure on the surface of the colonic mucosa, and calculating a continuous homology feature set of the lesion area; and based on the persistent homology feature set, constructing a multi-scale graph neural network model of ulcerative colitis and Crohn disease specificity. By implementing the scheme, the structural and topological modeling of the colon mucosa lesion area can be realized, and the morphological characteristic difference between ulcerative colitis and Crohn's disease can be effectively captured. The multi-scale graph neural network fuses macroanatomical segmentation and micropathology features, efficient distinguishing of continuous and jumping lesions is achieved, finally, an intelligent and visual endoscope evaluation report is generated, and the accuracy and real-time performance of auxiliary diagnosis in an operation are improved.

The invention discloses a cyclic hexapeptide for skin care and a composition and application thereof, and relates to the technical field of polypeptides, and the cyclic peptide has the following structure: Cyclo-[Arg-Arg-Gln-D-Met-Glu-Glu]. Specifically, the invention relates to the cyclic peptide or the salt thereof, or a composition of the cyclic peptide and the salt thereof, and application of the cyclic peptide and the salt in preparation of a composition for nursing or treating skin or mucosa.

The invention provides a composition capable of penetrating an intestinal barrier by oral administration. The composition contains a carrier or an auxiliary material of a targeted Microflod cell Dectin-1 receptor, and one or / and a plurality of medicinal components / components, wherein the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan, and the carrier or the auxiliary material of the target Microflood cell Dectin-1 receptor is beta-glucan. The effective components / components are traditional Chinese medicine effective components / components, or / and probiotics, or / and chemical medicine components, or / and biological medicines. The invention relates to a composition capable of realizing oral administration and penetrating through an intestinal barrier, which is based on the discovery of the inventor that the composition reaches colon through gastrointestinal tracts, targets colon Microflood cells, is taken by the Microflood cells, penetrates through the intestinal barrier and enters immune tissue Colonic Patches of a colon submucosa. Based on the research, the composition disclosed by the invention can be used for treating various diseases, such as ulcerative colitis, Crohn's disease, colon cancer, rheumatoid arthritis or bacterial pneumonia after being orally taken and absorbed by rectum.

The invention provides an insertion part, an endoscope and a suction system, and relates to the technical field of endoscopes, the insertion part comprises a tube body, the tube body is provided with a first fluid channel, and the tube body is used for being inserted into a sheathing canal; the second fluid channel is arranged in the axial direction of the tube body, a far port of the second fluid channel is adjacent to a far port of the first fluid channel, and a near port of the second fluid channel is used for being communicated with a sheath tube; the driving part is connected with the second fluid channel and used for driving the second fluid channel to deform in the radial direction of the tube body, and therefore the radial size and the corresponding section flow area of the second fluid channel are adjusted. Friction between the outer wall of the ureter and the inner wall of the ureter can be effectively reduced, mucous membranes are prevented from being pressed or torn, and therefore the risk of postoperative bleeding, infection and the like is reduced.

The invention discloses a normal-temperature bacteria liquid enteric-coated targeted colonization microcapsule and a preparation method thereof. The invention belongs to the technical field of biological medicine. The structure of the room-temperature bacterial liquid protection microcapsule is as follows: an inner layer is an activity maintaining layer and mainly consists of a sodium alginate-calcium chloride polyelectrolyte compound (the thickness is 50-100 microns); the middle layer is a pH response release layer and is mainly composed of hydroxypropyl methyl cellulose phthalate (HPMCP, dissolved at pH of 6.8 or above) and nano calcium carbonate particles (the particle size is 50nm, and the proportion is 10% w / w); the outer layer is a mucous membrane adhesion layer, and the main components of the mucous membrane adhesion layer comprise fucose modified chitosan (Fuc-CS, targeted colonic mucous membrane lectin protein) and carbomer 940 (pH sensitive adhesion polymer); the method is a microcapsule capable of preserving the bacterial liquid at normal temperature and accurately targeting colon release and adhesion colonization and a process thereof, the problem of flora activity loss caused by a freeze-drying process can be solved, in addition, the process does not need freeze-drying equipment, and the production cost is reduced.

The invention provides a duodenal mucosa adjusting system and method based on pulsed electric field ablation and application of the duodenal mucosa adjusting system and method in diabetes treatment, the duodenal mucosa adjusting system comprises an intelligent control host capable of achieving bidirectional data transmission and an adjustable catheter, and the intelligent control host initializes parameters and adjusts pulse parameters by monitoring impedance data in real time until pulses are interrupted or terminated; periodic ablation is carried out, periodic intervals are used for measuring impedance data, the ablation depth is evaluated according to the impedance change rate, and whether next section ablation is carried out or not is judged till full-area ablation is completed. The far-end ablation adopts a structure of combining fusiform flexible support and annular electrode spiral arrangement to ensure that an ablation field uniformly covers mucous membrane plica of a duodenum bulb part and a descending part; a cell selective ablation mechanism is adopted, the critical electric field intensity is set, K cell electroporation is selectively induced, and meanwhile goblet cells are protected.

The invention relates to the technical field of RT type lacrimal passage drainage tube application, and particularly discloses an RT tube application method for simultaneously solving upper and lower lacrimal passage blockage, which comprises the following steps of: firstly, performing preoperative local anesthesia on a patient; the upper lacrimal punctum and the lower lacrimal punctum of the diseased eye are expanded, and after a thin probe is used for probing the obstruction position of the lacrimal passage from the upper lacrimal ductule and the lower lacrimal ductule, the lacrimal passage is flushed Expanding the obstructed part of the lacrimal passage by using a large probe; then, the artificial lacrimal duct is implanted, the RT tube is implanted into the upper and lower lacrimal ducts at the same time, the problem of blockage of multiple parts is solved through a single instrument, repeated damage to periorbital tissue caused by fractional operations is avoided, and the device is particularly suitable for complex cases that upper and lower lacrimal canalicules and nasolacrimal ducts are blocked or narrow at the same time; the whole-course drainage of the tears from the upper and lower lacrimal passages to the nasal cavity is further ensured, and the physiological path of tear circulation is recovered; the RT tube is placed, skin or mucous membrane does not need to be cut open, no scar is visible after operation, and the requirement for periocular beauty is met.

The invention discloses an oral care composition and a preparation method thereof, the oral care composition comprises a friction agent, a periodontal repair agent, a thickening agent, a humectant and a foaming agent, the friction agent comprises a dental plaque release agent, and the dental plaque release agent is configured to destroy a bacterial extracellular polysaccharide matrix in dental plaque; the periodontal repair agent comprises at least one of the following components: an inflammation inhibitor, a tissue repair promoter, a mucous membrane stimulation alleviator and a bacteriostatic agent. The oral care composition contains the dental plaque release agent and the periodontal repair agent, and can synergistically improve periodontal health.

Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, those within the respiratory tract, particularly the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The systems may be used to treat pathogens, such as bacteria and viruses, particularly coronaviruses.

The invention relates to the technical field of medical auxiliary instruments, and discloses a nasal cavity dilatation stent and an implantation tool thereof. According to the nasal cavity dilatation support and the implanting tool thereof, the inflatable air bag is connected with the inflatable tube of the elastic air bag layer through the connecting tube and is matched with the one-way valve in the middle, step-by-step inflation can be achieved, the dilatation degree can be conveniently adjusted according to needs, gas backflow can be prevented, and the elastic air bag layer at the outer end of the nasal cavity dilatation sleeve achieves nasal cavity dilatation through inflation expansion. Compared with point contact of a traditional rigid metal dilator, the air bag layer and the nasal cavity wall form surface contact, the contact pressure intensity is reduced, and the mucous membrane compression injury rate is synchronously reduced; meanwhile, the elastic characteristic of the air bag can adapt to individual differences of nasal cavities of different patients, instruments of different specifications do not need to be replaced, medical staff can operate an elastic clamp with one hand to clamp the two nasal cavity dilatation sleeves to be stuffed into the two nasal cavities of the patients through arrangement of the implantation assembly, use is rapid and convenient, and the practicability is high. And the practicability of the nasal cavity dilatation stent and the implanting tool thereof is improved.

The sputum suction equipment comprises a main body box, the driving assembly is mounted in the main body box, and the output end of the driving assembly extends out of the main body box; the sputum suction assembly is mounted at the output end of the driving assembly; the double-layer film is mounted at the suction end of the sputum suction assembly; according to the technical scheme, the driving assembly is adopted to drive the sputum suction assembly to rotate, the rotating spiral back suction head makes uniform contact with the oral cavity of a patient, and mucosa damage caused by single-point repeated friction is avoided; and stubborn sputum scab and thick sputum can be cleaned through rotation of the spiral back-suction head, the spiral groove guides the sputum to gather towards the head of the spiral back-suction head, side wall adsorption is reduced, more sputum can be conveniently sucked into the spiral back-suction head, and more efficient sputum suction is achieved.

The invention relates to the technical field of medical image processing, in particular to an enterostomy mucous membrane state evaluation system based on color comparison, which comprises a multi-modal data acquisition module used for acquiring and analyzing a mucous membrane image sequence, ambient light characteristics and basic physiological data and generating acquisition data records with aligned timestamps; and the individualized benchmark modeling module is used for establishing a patient specific color reference benchmark through HSL color space analysis on the basis of the collected data records and the preoperative physiological indexes, and generating an initial adaptive color gamut threshold model. According to the method, the specific initial color reference is established for each patient, and the sliding window algorithm is combined to continuously monitor the color gamut drift so as to dynamically update the reference, so that accurate self-adaption to individual physiological differences of the patients and postoperative slow recovery changes is realized, and therefore, the objectivity and accuracy of evaluation are greatly improved; the problem of misjudgment caused by individual differences or normal evolution of physiological states in a traditional fixed threshold value method is effectively avoided.

A detachable multi-loop traction device for insertion into a body through a forceps tube of an endoscope, in which when a diseased mucous membrane in the body is resected by an extracorporeal operation, the traction device is provided with a plurality of loops for traction of the diseased mucous membrane. The detachable multi-ring traction device is configured to be fixed to the lesion mucous membrane and a normal mucous membrane opposite to the lesion mucous membrane through clamps. The detachable multi-ring traction device is provided with a plurality of annular rings having a large circle and a small circle, and two adjacent rings are connected with each other in a manner of being connected with each other in the diameter direction of the large circle in a state that outer edge parts of the two adjacent rings are connected with each other.

According to the endoscope imaging fusion enhanced imaging method and device, imaging characteristics of white light (an overall structure background), red light (a deep blood vessel), green light (a high-contrast capillary vessel) and blue light (an enhanced surface microstructure) are comprehensively utilized, digestive tract mucosa can be analyzed in a layered mode, and comprehensive diagnosis and early focus recognition from the surface layer to the deep layer are achieved; during image fusion, adaptive weight configuration based on focus types is supported by adopting a weight dynamic adjustment mechanism, so that the quality of the finally fused image is influenced, and therefore, a neural network architecture is adopted to train each channel weight, and a more reasonable weight value can be obtained.

The invention discloses a digital stable jaw pad designing and manufacturing method, and relates to the technical field of oral rehabilitation and digital medical technology.The digital stable jaw pad manufacturing method comprises the following steps that a, three-dimensional point cloud data of oral dentition and mucosa of a patient is obtained through a three-dimensional scanner; b) determining a stable jaw position coordinate model by using an optical motion capture system; c) designing a jaw pad three-dimensional entity model with an anterior tooth area, a posterior tooth area and an edge structure based on the three-dimensional point cloud data and the stable jaw coordinate model; and d) manufacturing the jaw pad through 3D printing equipment, wherein the 3D printing equipment is formed by adopting a polyether-ether-ketone material. By integrating digital acquisition, design and manufacturing technologies, the pain point of a traditional method is solved, and personalized, high-precision and rapid manufacturing of the stable jaw pad is realized.

The invention provides an application of a lactobacillus paracasei IOB413 metagen in prevention of helicobacter pylori infection, and relates to the technical field of microorganisms. The lactobacillus paracasei IOB413 metaplasm can competitively occupy gastric epithelial cell adhesion sites to directly block the initial colonization of helicobacter pylori, so that infection preposed interception is realized, and the lactobacillus paracasei IOB413 metaplasm is suitable for early prevention of high-incidence people. The compound has dual mechanisms of site blocking and urease inhibition, and can cooperate with antibiotics to improve the eradication rate and reduce the drug resistance. Animal experiments show that the traditional Chinese medicine composition can reduce gastric mucosa proinflammatory factors in a dose-dependent manner, improve the activity of antioxidant enzymes, reduce lipid peroxidation products, relieve mucosa lesion, promote repair and reduce the risk of complications; moreover, gastrointestinal hormone disorder can be reversed, the digestive function is maintained, and related discomfort is relieved.

The invention belongs to the technical field of biological materials, and particularly relates to a conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity and a preparation method of the conductive hydrogel microneedle patch. The preparation method comprises the following steps: firstly, loading plant essential oil with antibacterial and anti-inflammatory activity on mesoporous polypyrrole nanoparticles to prepare drug-loaded nanoparticles, then preparing a pre-hydrogel mixture containing the drug-loaded nanoparticles, and then filling the mixture into a PDMS microneedle mold to obtain the conductive hydrogel microneedle patch with antibacterial and anti-inflammatory activity. The prepared microneedle patch not only has excellent antibacterial and anti-inflammatory activity and a conductive function, but also has the characteristics of a microneedle and hydrogel, and can deliver a drug to a skin cuticle or a lower layer of a bacterial biofilm, so that the bioavailability of transdermal drug delivery of the drug is greatly improved. Besides, the microneedle patch is swelled after absorbing tissue exudate, is adhered to the surface of skin or other mucous membranes to continuously play antibacterial and anti-inflammatory roles and conductive functions, and provides wet healing conditions, so that high-quality healing of skin wounds is accelerated.

The invention discloses a capsule medicament for endoscopic treatment of ulcerative colitis and a preparation method thereof, and belongs to the technical field of biological medicine, the capsule medicament is composed of a capsule matrix and a drug matrix; by adopting a dual control mechanism of an enteric layer coating and a pH response layer coating, accurate release of a medicine at a colon diseased region is ensured, medicine waste of the stomach and the small intestine is reduced, the medicine concentration at a focus is improved, mesalazine or budesonide is combined with the composite composition for treatment, inflammatory response is rapidly inhibited, acute symptoms are controlled, and the curative effect is good. A multi-mechanism synergistic treatment mode is adopted, the anti-inflammatory and repairing effects are enhanced, the clinical remission rate and the mucous membrane healing rate are remarkably improved, the pH response layer is dissolved in a colon alkaline environment, and the MMP-9 peptide cross-linking agent is subjected to enzymolysis at an inflammation part, so that the medicine is continuously released at a focus, the administration frequency is reduced, the compliance of a patient is improved, and the curative effect is good. In addition, the spherical gel particles in the medicament can prevent the medicament from being disintegrated too early in the intestinal tract, and the long-acting effect can be maintained.

The utility model relates to the technical field of medical instruments, in particular to a nasal cavity suction tube which comprises an extension tube, one end of the extension tube is in threaded connection with a fixed tube, one end, far away from the extension tube, of the fixed tube is in threaded connection with a bent tube, and first suction holes which are circularly distributed at equal intervals are formed in the circumferential outer wall of the bent tube; an anti-backflow assembly is arranged in the extension pipe, a spiral blade is fixedly connected to the circumferential inner wall of the fixed pipe, and a suction head is fixedly connected to the end, away from the fixed pipe, of the bent pipe. According to the nasal cavity aspirator, due to the fact that the bent pipe extends into the nasal cavity of a patient, the nasal cavity aspirator can be better attached to the nasal cavity of the patient, foreign matter in the nasal cavity of the patient can be rapidly sucked out, and one end of the bent pipe is provided with four sets of first suction holes and one set of second suction holes so that multi-hole suction can be conducted on the patient; the situation that a group of suction holes are blocked when being adsorbed to the surface of a soft and easily-deformed mucous membrane is avoided, and the circulation of the whole suction tube is ensured.

The invention relates to the field of biomedical materials, in particular to polyethyleneimine / polyacrylic acid-based hydrogel for wound repair and a preparation method of the polyethyleneimine / polyacrylic acid-based hydrogel. The hydrogel is prepared by the following steps: dissolving polyacrylic acid with a specific polymerization degree, reacting with a cross-linking agent and an initiator, treating to obtain a polyacrylic acid group, and mixing and stirring with a polyethyleneimine aqueous solution. In the preparation process, the raw material proportion, reaction conditions and other parameters are accurately controlled. The hydrogel has a unique microstructure and physicochemical properties, such as appropriate swelling ratio, mechanical strength and surface charge density, and has good tissue adhesion and antibacterial property in wound repair, and degradation products are harmless. The method can also be used for preparing medical dressings, and has a wide application prospect in the field of wound repair of skin, mucous membranes and the like.

A surgical anchor device for being anchored on the mucous membrane of the inner wall of the intestine, the device having a temporary anchor element presenting anchoring that can be modified in a controlled manner and having a first substantially cylindrical multiply-perforated wall presenting properties of radial elasticity whereby the first wall presents an outer diameter that can be varied in controlled manner, wherein a portion of the inner surface of the first wall is lined with an independent leakproof inner sheath having only its longitudinal ends fastened to the anchor element to define a suction chamber between the inner sheath and the first wall, the temporary anchor element being coupled to a flexible or semi-rigid tube extending outside the anchor element, an open end of the injection-suction tube opening out into the suction chamber enabling air to be injected into or sucked out from the suction chamber.

The invention relates to the technical field of image processing, and discloses an endoscope image imaging method and an endoscope, and the endoscope image imaging method comprises the steps: obtaining a real-time collection image of the endoscope and a light source parameter of the endoscope; positioning a target light spot in the real-time acquired image based on light source parameters of the endoscope; suppressing a specular reflection component of a target area where the target light spot is located to obtain an endoscope imaging image; the method comprises the following steps: firstly, positioning a light spot in a real-time acquired image based on a light source parameter to obtain a target light spot; the specular reflection component of the target area where the target light spot is located is further suppressed, so that the overexposure spots can be suppressed while global processing damage to normal highlight areas such as highlight bleeding spots and highlight mucous membranes can be avoided, and the original expression of the image can be restored.

The present invention relates to a device for the prevention and / or treatment of fecal and / or urinary incontinence. The device may fit into a vagina. The device may include a pressure sensor and electrodes. The device may include a lateral projection on the device and / or a skin of the device. In response to intra-abdominal pressure the device may apply electrostimulation with the electrodes, for example to a vaginal mucosa.

The invention is suitable for the technical field of gynecological gels, and provides a gynecological gel with a repairing effect. Comprising the following components in percentage by weight: 0.1%-0.5% of recombinant III type human collagen, 0.05%-0.2% of mussel mucin, 1%-3% of chitosan, 0.2%-1% of sodium hyaluronate, 2%-5% of lactobacillus fermentation product filtrate, 0.05%-0.2% of tea tree essential oil, 0.2%-0.5% of carbomer, 0.1%-0.4% of triethanolamine, 0.1%-0.2% of sodium methylparaben and the balance of purified water. The gynecological gel with the repairing effect has the excellent repairing effect, integrates multiple effects of effectively resisting bacteria and diminishing inflammation, promoting repairing of damaged vaginal mucosa, adjusting vaginal micro-ecological balance and the like, not only can efficiently inhibit growth of various pathogens, but also can remarkably promote proliferation and repairing of vaginal mucosa cells, and has the advantages that the repairing effect is good, and the repairing effect is good. The vaginal micro-ecological balance can be accurately adjusted, no stimulation is caused to vaginal mucosa, safety and reliability are achieved, and long-term use can be achieved.

The invention discloses a submucous membrane multi-point thickness measuring method for endoscopic submucous membrane dissection. The submucous membrane multi-point thickness measuring method comprises the following steps that images are collected, wherein pathological images cut by the endoscopic submucous membrane dissection are obtained; image preprocessing: improving the brightness of the pathological image and the contrast ratio of a bright part, and smoothing the pathological image through Gaussian filtering; image feature extraction: extracting texture features of the pathological image, using a local binary pattern (LBP) algorithm, and generating a vertical coordinate feature map with the same size as the pathological image; feature fusion: superposing the preprocessed noise reduction image, the texture feature image and the ordinate feature map; submucous membrane pathological tissue segmentation: using a UNet neural network to carry out image segmentation task training on the superimposed image; calculating the thickness of multiple points; and quality evaluation. According to the method, the thickness of the submucous membrane is measured through the pathological tissue image, and ESD effect judgment and operation quality control are facilitated.

The invention discloses an oral mucosa scraping device which comprises an outer sleeve, an expansion assembly and a sampling assembly. The expansion assembly comprises tooth supporting plates, a push ring, a control assembly and a connecting rod, the control assembly is pushed to drive the push ring to move forwards, the push ring is in linkage with the connecting rod to drive the tooth supporting plates to move, and the distance between the tooth supporting plates is adjusted; the sampling assembly comprises a sampling sleeve, a handheld holding rod, a sampling rod and a sampling scraping plate, the front end of the sampling sleeve is close to the position needing to be scraped, the front end of the sampling rod makes contact with the oral mucosa, the handheld holding rod is rotated to be matched with the sampling scraping plate to scrape the oral mucosa, and scraped tissue is scraped into the sampling cavity. According to the device, the risk of soft tissue injury is reduced through a symmetrical gradual distraction structure and a mechanical linkage design; the design of a modular guide channel, scale marks and a closed sampling cavity is combined, stable adjustment of the scraping angle and pollution-free sample transfer are achieved, and accurate sampling and result accuracy guarantee are both considered.

The invention discloses a symmetric nucleoside microneedle patch loaded with polymer vesicles as well as a preparation method and application of the symmetric nucleoside microneedle patch. The symmetric nucleoside microneedle patch loaded with the polymer vesicles comprises a guanosine-quadruplex hydrogel microneedle tip doped with drug-loading polymer vesicles, the raw material of the drug-loaded polymer vesicle comprises a polycaprolactone-polyglutamic acid copolymer; the guanosine-quadruplex hydrogel is prepared from the following raw materials: guanosine and KB (OH) 4. The microneedle patch is constructed on the basis of dynamic covalent bond and non-covalent interaction, has a sharp tip array capable of penetrating the epithelium and the lower layer of a mucous membrane, can efficiently deliver a drug to a canker lesion part by bypassing a mucous membrane barrier, can be controllably broken under a high ROS condition of an inflammation microenvironment, has the characteristics of high drug delivery efficiency and high accuracy, and can be used for preparing a medicine for treating the canker lesion part. The effect of effectively improving chemotherapy-induced oral ulceration can be achieved by reducing inflammatory response, relieving pain feeling and inhibiting pain sensitization.