959 results about "Mucous membrane" patented technology

The invention discloses an oral care composition and a preparation method thereof, the oral care composition comprises a friction agent, a periodontal repair agent, a thickening agent, a humectant and a foaming agent, the friction agent comprises a dental plaque release agent, and the dental plaque release agent is configured to destroy a bacterial extracellular polysaccharide matrix in dental plaque; the periodontal repair agent comprises at least one of the following components: an inflammation inhibitor, a tissue repair promoter, a mucous membrane stimulation alleviator and a bacteriostatic agent. The oral care composition contains the dental plaque release agent and the periodontal repair agent, and can synergistically improve periodontal health.

The invention relates to the technical field of medical image processing, in particular to an enterostomy mucous membrane state evaluation system based on color comparison, which comprises a multi-modal data acquisition module used for acquiring and analyzing a mucous membrane image sequence, ambient light characteristics and basic physiological data and generating acquisition data records with aligned timestamps; and the individualized benchmark modeling module is used for establishing a patient specific color reference benchmark through HSL color space analysis on the basis of the collected data records and the preoperative physiological indexes, and generating an initial adaptive color gamut threshold model. According to the method, the specific initial color reference is established for each patient, and the sliding window algorithm is combined to continuously monitor the color gamut drift so as to dynamically update the reference, so that accurate self-adaption to individual physiological differences of the patients and postoperative slow recovery changes is realized, and therefore, the objectivity and accuracy of evaluation are greatly improved; the problem of misjudgment caused by individual differences or normal evolution of physiological states in a traditional fixed threshold value method is effectively avoided.

The invention discloses a digital stable jaw pad designing and manufacturing method, and relates to the technical field of oral rehabilitation and digital medical technology.The digital stable jaw pad manufacturing method comprises the following steps that a, three-dimensional point cloud data of oral dentition and mucosa of a patient is obtained through a three-dimensional scanner; b) determining a stable jaw position coordinate model by using an optical motion capture system; c) designing a jaw pad three-dimensional entity model with an anterior tooth area, a posterior tooth area and an edge structure based on the three-dimensional point cloud data and the stable jaw coordinate model; and d) manufacturing the jaw pad through 3D printing equipment, wherein the 3D printing equipment is formed by adopting a polyether-ether-ketone material. By integrating digital acquisition, design and manufacturing technologies, the pain point of a traditional method is solved, and personalized, high-precision and rapid manufacturing of the stable jaw pad is realized.

A surgical anchor device for being anchored on the mucous membrane of the inner wall of the intestine, the device having a temporary anchor element presenting anchoring that can be modified in a controlled manner and having a first substantially cylindrical multiply-perforated wall presenting properties of radial elasticity whereby the first wall presents an outer diameter that can be varied in controlled manner, wherein a portion of the inner surface of the first wall is lined with an independent leakproof inner sheath having only its longitudinal ends fastened to the anchor element to define a suction chamber between the inner sheath and the first wall, the temporary anchor element being coupled to a flexible or semi-rigid tube extending outside the anchor element, an open end of the injection-suction tube opening out into the suction chamber enabling air to be injected into or sucked out from the suction chamber.

The present invention relates to a device for the prevention and / or treatment of fecal and / or urinary incontinence. The device may fit into a vagina. The device may include a pressure sensor and electrodes. The device may include a lateral projection on the device and / or a skin of the device. In response to intra-abdominal pressure the device may apply electrostimulation with the electrodes, for example to a vaginal mucosa.

The invention provides a preparation method of a Witzia ciliaris IOB502 microbial inoculum and an application of the Witzia ciliaris IOB502 microbial inoculum in the aspect of recovering intestinal motility, the Witzia ciliaris IOB502 microbial inoculum is prepared by adopting a method of carrying out low-oxygen stress staged fermentation on chickpeas by adopting the Witzia ciliaris IOB502, and the generation of vitamins B1 and B2 can be promoted. The microbial inoculum does not affect physiological development of important organs such as liver, spleen and small intestine of mice, can improve defecation symptoms of the mice with constipation, increase defecation times and water content of excrement, improve intestinal movement of the mice with constipation, promote smooth passage of intestinal contents, effectively improve colon injury of the mice with constipation, and improve the constipation rate of the mice with constipation. Comprising mucous membrane layer thinning and mucus secretion reduction.

The invention belongs to the technical field of biological medicine, and particularly relates to eutectic gel, a preparation method thereof and application of the eutectic gel in promoting mucous membrane drug delivery. The invention provides eutectic gel. The eutectic gel comprises a eutectic solvent and a polymer solution, the eutectic solvent comprises a hydrogen bond acceptor and a hydrogen bond donor; the polymer solution is selected from one or more of a gelatin solution, a polyvinyl alcohol solution, a polyethylene solution or a pyrrolidone solution. The eutecticevaporate gel provided by the invention can realize rapid and tight adhesion and continuous administration on mucous membranes which continuously secrete mucus, and has the following advantages: tight adhesion can be formed on mucous membranes with dynamically updated mucus, so that the residence time of an administration system on the mucous membranes is prolonged; and a drug delivery channel is established by penetrating through a mucous layer, so that the drug is efficiently and continuously delivered to mucous membrane tissues. The deep eutectic gel effectively solves the problem that an existing mucous membrane drug delivery system is low in drug delivery efficiency.

The invention discloses an intelligent auxiliary diagnosis and grading system for gastrointestinal tumor endoscopic images, which belongs to the technical field of medical image processing and computer-aided diagnosis and comprises a multi-modal image preprocessing and segmentation module, a lesion feature extraction and diagnosis module, a grading and depth evaluation module and a closed-loop feedback optimization module. The system receives white light, a narrow band and an amplified endoscopic image, adaptive segmentation is performed to obtain a lesion area, mucous membrane morphology, capillary and gland features are extracted, Paris classification, Vienna classification and infiltration depth evaluation are realized, and segmentation parameters are subjected to closed-loop optimization according to classification confidence. And intelligent auxiliary support is provided for early diagnosis and treatment decision of gastrointestinal tumors.

The invention relates to the technical field of rhinitis spray preparation, in particular to a method for preparing allergic rhinitis spray from umbilical cord mesenchymal stem cell exosomes, which comprises the following steps: 1, umbilical cord treatment; 2, culturing umbilical cord mesenchymal stem cells; 3, preparing an umbilical cord mesenchymal stem cell exosome; and 4, preparing the rhinitis spray. The rhinitis spray prepared by the method disclosed by the invention is simpler and more convenient to use. The exosome, the platelet growth factor and other substances in the rhinitis spray well solve the core problems of single curative effect, large side effect, low compliance and the like in the traditional rhinitis treatment, and through the induction and repair functions of the stem cell exosome and the bactericidal ability of the antibacterial peptide, the nasal cavity environment is improved, the anaphylactic reaction is reduced, the nasal mucosa is repaired, and the rhinitis treatment effect is improved. The allergic rhinitis is expected to be fundamentally treated.

The invention discloses an intelligent classification and recognition method for ear-nose-throat lesion images, and relates to the technical field of image recognition, and the method comprises the steps: synchronously collecting a nasopharynx white light image and an i-Scan image, screening an image meeting a quality standard, carrying out the correlation of pathology and grading labeling, and constructing a data set containing a multi-center case; the white light image and the i-Scan image are subjected to denoising processing, key mark points are extracted, image registration is completed, a mucous membrane surface area, a submucous membrane blood vessel area and a lymphatic tissue enrichment area are divided through semantic segmentation, and feature enhancement is carried out on different areas; extracting morphological features and textural features from the enhanced image, calculating feature importance weights and fusing the feature importance weights into low-dimensional feature vectors; the benign and malignant dichotomy model and the pathological type multi-classification model are respectively constructed, and classification results are output in combination with a doctor diagnosis rule base and verification indexes, so that the accuracy and clinical practicability of ear-nose-throat lesion diagnosis are remarkably improved.

The invention belongs to the technical field of medical instruments, and discloses a digestive endoscopy diseased region accurate positioning and marking device which comprises a controller, an endoscope hose is fixedly connected to the bottom of the controller, and an instrument insertion opening is formed in the right side of the controller. Through the arrangement of the sleeve, the dye tube, the pressurization air bag and the baffle, after an operator observes a diseased region through the endoscope hose, the operator only needs to align the endoscope hose to the diseased region, and by pressing the pressurization air bag, air in the pressurization air bag enters the dye tube through the inner hose; the baffle can be pushed to rotate outwards under the action of air pressure, meanwhile, methylene blue in the dye tube is sprayed out under the action of air flow, a diseased region is marked, the methylene blue can be absorbed by normal mucous membrane cells, and diseased tissue shows dyeing difference due to abnormal cell function and poor absorption capacity, so that the diseased region is marked. Therefore, the effect of accurate positioning is achieved.

The invention discloses a throat mucosa intelligent state evaluation and inflammation early warning management system and method. The method comprises the following steps: synchronously acquiring a throat mucosa image, breath sound / cough sound / sounding signals, airflow data and body temperature or environment relative humidity data, evaluating image definition, shielding degree and coverage rate, and outputting acquisition guide superposition information and triggering re-acquisition when the image does not reach the standard; reliability is calculated for the multi-modal features, weight fusion output state vectors and confidence coefficients are determined in combination with quality gating, and cross-modal consistency verification is executed to trigger re-sampling or strategy adjustment; generating a risk index based on the change of the sliding time window, and outputting an early warning level by adopting hysteretic classification; and writing the threshold, the weight and the sampling and guiding strategy into a parameter library and a fusion model configuration area to form a closed loop. According to the system, improper electroencephalogram fusion and multi-terminal collaborative optimization can be selected, and daily scene evaluation stability and early warning reliability are improved.

Systems and methods utilizing RF energy to treat a patient's skin (e.g., dermis and hypodermis) or other target tissue including at a depth below a tissue surface (e.g., skin surface, mucosal surfaces of the vagina or esophagus) are provided herein. In various aspects, the methods and systems described herein can provide a RF-based treatment in which the deposition of RF energy can be selectively controlled to help ensure heating uniformity during one or more of body sculpting treatment (lipolysis), skin tightening treatment (laxity improvement), cellulite treatment, vaginal laxity or rejuvenation treatment, urinary incontinence treatment, fecal incontinence treatment, all by way of non-limiting examples. In various aspects, the systems can comprise one or more sources of RF energy (e.g., a RF generator), a treatment applicator comprising one or more electrode arrays configured to be disposed in contact with a tissue surface, and a return electrode (e.g., a neutral pad) to the tissue surface.

The invention provides a nomeline nasal-brain delivery preparation for transnasal region mucosa administration, and an auxiliary material mixture of the nasal-brain delivery preparation comprises 1) phospholipid, and 2) any one of diluent ethyl oleate, isopropyl myristate, sesame oil or castor oil; optionally, the auxiliary material mixture can also comprise 3) a dissolving agent such as ethanol or diethylene glycol monoethyl ether, the auxiliary material mixture is a non-aqueous system, and a solution prepared from the mixture of the two or three auxiliary materials can be absorbed by the nasal meatus olfactory mucosa after being administrated through the nasal region mucosa, can be quickly conducted to the brain olfactory bulb region along olfactory nerves and cerebrospinal fluid, and can be used for treating the brain olfactory bulb. The problems that the peripheral side effect is high due to poor brain targeting of the medicine, the medicine takes effect slowly and the like are solved.

The invention discloses a mannose modified liposome gel microsphere oral delivery system based on cations and application of the mannose modified liposome gel microsphere oral delivery system. The oral delivery system comprises a core layer and a wrapping layer, the core layer is mannose modified cationic liposome loaded with a mucous membrane adjuvant retinoic acid and an antigen, and the wrapping layer is sodium alginate gel vulcanized and modified by cysteine. The mannose modified cationic liposome is prepared by coupling mannose on the surface of the cationic liposome, and the cysteine modified sodium alginate gel is used for protecting antigens in the core layer from being eroded by gastric juice, enhancing the adhesiveness of a delivery system in the intestinal tract and prolonging the retention time of the delivery system in the intestinal tract; in addition, the R-MLip can be expanded and released under the environment that the pH of the intestinal tract is increased. The inside of the gel microsphere of the oral delivery system shows a regular net-shaped structure and has abundant holes and channels, and the oral delivery system shows a good prospect in the aspect of enhancing mucous membrane and systemic immunity and possibly becomes a potential substitute of a traditional attenuated live vaccine in the future.

The invention relates to the technical field of microorganisms, and particularly discloses bifidobacterium longum LFS01 and application thereof. The bifidobacterium longum LFS01 is preserved in the China General Microbiological Culture Collection Center on July 9, 2025, the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.35159, and the bifidobacterium longum LFS01 is classified and named as the bifidobacterium longum LFS01. The bifidobacterium longum LFS01 provided by the invention can be specifically and efficiently colonized in an intestinal tract after gut cleaning, proliferation of pathogenic bacteria is inhibited through competitive rejection, an intestinal barrier is repaired in a multi-target manner, intestinal inflammation can be effectively relieved, a flora structure can be improved, mucous membrane integrity can be recovered, and the intestinal tract can be effectively protected. A safe and effective biological prevention and treatment strategy is provided for solving the problems of flora disorder and pathogenic bacterium infection caused by gut purging.

The invention relates to a gastric acid-resistant sustained-release intestinal bacteria capsule based on bionic mucous membrane-enzymolysis response and a preparation method thereof. The gastric acid-resistant sustained-release intestinal bacteria capsule comprises a core layer, an adhesive layer, an outer-layer composite film and a protective coating from inside to outside, the core layer consists of intestinal flora and a multifunctional freeze-drying protective agent; the adhesive layer is composed of trehalose, N-acetyl glucosamine and MUC2 recombinant protein; the outer-layer composite film is composed of a base material and a functional filler; the protective coating is composed of beewax and chitosan. The anti-gastric acid sustained-release intestinal bacteria capsule based on bionic mucosa-enzymolysis response provided by the invention has excellent gastric acid resistance, and the gastric acid resistance is remarkably improved; good slow release performance is achieved, and accurate slow release of enzymatic hydrolysis response can be achieved; the colonization efficiency of the intestinal bacteria can be effectively improved; the storage stability is good. The preparation method provided by the invention has the advantages of simplified steps, short time consumption, controllable core operation time and obviously shortened whole process, and is beneficial to keeping the activity of the flora.

The invention relates to the technical field of orthodontics and medical image processing, in particular to an artificial intelligence-based automatic positioning method and system for a maxillary bone expansion device. The positioning method comprises the following steps: taking a cone beam computed tomography image and intraoral scanning data of a patient; segmenting a key anatomical structure based on the scanned image, wherein the key anatomical structure comprises an incisor foramen and a transverse palate slit; automatically identifying a plurality of cranio-maxillofacial mark points based on the scanned image, and establishing a maxilla three-dimensional coordinate system; based on the three-dimensional coordinate system, the intraoral scanning data and the key anatomical structure, positioning adjustment is carried out on the arch expander to determine the final positioning posture, and positioning adjustment comprises the steps that the safe distance between the arch expander and the surface of the palate mucosa is screened, and contact with the key anatomical structure is avoided; and outputting the three-dimensional parameters of the final positioning posture. According to the invention, the automatic, intelligent and safe placement of the arch expanding device is realized, so that the design efficiency is improved, the operation difficulty is reduced, and the clinical safety and the arch expanding effect are guaranteed.

The invention relates to the technical field of biopsy picking devices, and particularly discloses a gastrointestinal endoscope biopsy picking device which comprises a flexible outer tube. The fixing base is fixedly connected with the end part of the flexible outer pipe; the number of the clamp flaps is two, and meshing teeth are arranged on the sides, close to each other, of the two clamp flaps; the opening and closing mechanism penetrates through the flexible outer tube and is connected with the two clamp flaps; according to the gastrointestinal endoscope biopsy extraction device, the expansion mechanism expands through the trigger type air bag, so that the root of a deep plica is expanded outwards, a dead angle area which cannot be expanded through conventional air injection is fully exposed, a doctor does not need to manually control an endoscope to push the plica or adjust the angle, semi-blind operation is not needed, missed diagnosis of a hidden focus is avoided, and the operation efficiency is improved. After the plica is unfolded, the clamp flaps can be vertically attached to a focus mucous membrane, the staggered design of the meshing teeth ensures that a tissue sample is firmly fixed, the focus is automatically exposed through the expansion mechanism, the endoscope view is clear, the operation process is simplified, and the sampling failure rate is reduced.

The invention discloses a breeding method and device for breeding boars, belongs to the technical field of breeding of the boars, and aims to solve the problems that in order to prevent seminal fluid from flowing out after insemination, an external air source is often relied on, so that discomfort of sows is easily caused, and the success rate of fertilization is influenced. The problem that the pregnancy effect is affected due to the fact that a pipeline is left in the body for a long time and discomfort of a pig is easily caused is solved, the gel suppository can be attached to the irregular mucous membrane form of the cervix uteri inner opening after being expanded, leakage caused by reserved gaps is avoided, the expansion degree does not need to be manually controlled, the error-tolerant rate is higher, and the application range is wide. Meanwhile, the plugging mechanism of the gel suppository is made of a natural degradation material, can be naturally degraded and removed or discharged along with uterus peristalsis, has no long-term retention risk, can improve the vagina flushing effect, can simulate the action during mating in the vagina, facilitates fertilization reaction of sows and is more beneficial to successful fertilization.

The invention discloses a lactobacillus acidophilus FMM01 with the effects of improving the contractility of pelvic floor muscles and repairing mucous membranes and application of the lactobacillus acidophilus FMM01, the lactobacillus acidophilus FMM01 is preserved in the China Center for Type Culture Collection, the preservation date is January 9, 2024, and the preservation number is CCTCC NO: M2024052. The lactobacillus acidophilus FMM01 has the advantages of self-adaption, high acid resistance, strong mucous membrane adhesiveness and no irritation to vaginal mucosa. The lyophilized powder is high in activity and excellent in stability; experimental results show that the lactobacillus acidophilus FMM01 can effectively inhibit bacteria, and especially can effectively inhibit enterobacter cloacae, vibrio parahaemolyticus and / or candida albicans. Besides, the lactobacillus acidophilus FMM01 can improve vaginal relaxation, improve pelvic floor muscle contractility and / or recover vaginal mucosa functions, can promote recovery of healthy florae after mixed vaginitis antibiotic / hormone treatment, improves the treatment effect of mixed vaginitis, and remarkably reduces the recurrence rate of mixed vaginitis.

The present application relates to polypeptides and their use in repairing mucosal damage or skin damage, the polypeptides of the present application have no homology with known polypeptides, and can stably exist in vivo and in vitro, have the effect of regulating stem cell proliferation and differentiation to repair mucosal damage or skin damage; and relate to the use of the novel polypeptides to repair mucosal damage or skin damage by regulating stem cell proliferation and differentiation, and the use for preventing, alleviating or treating gastrointestinal diseases.

The present application belongs to the technical field of ostomy base plate, and particularly relates to a leakage-proof ostomy base plate for postoperative colorectal cancer, which comprises a suction cup, the upper side wall of the suction cup is fixedly connected with a connecting cylinder, the outer wall of the connecting cylinder is fixedly sleeved with two limiting rings matched with an ostomy bag, the outer wall of the suction cup is fixedly sleeved with an adhesive layer, the inner wall of the connecting cylinder is fixedly connected with an elastic film, and a center hole is formed in the center position of the elastic film. Before the ostomy base plate is used, the size and shape of the center hole of the ostomy base plate can be freely adjusted according to the use condition, so that the leakage risk of excrement caused by the size deviation of the manually cut traditional fixed circular center hole is avoided, the compression damage of the ostomy mucosa caused by the too small cutting is eliminated, the sealing property of the base plate and the skin around the ostomy is improved, the complications such as fecal dermatitis are reduced, the nursing operation difficulty is reduced, and the wearing comfort and the life quality of the patient are improved.

The application provides a self-pressure relief safety catheter, which comprises a main tube, an insertion tube, an elastic connecting tube and an air bag tube; the main tube has a first lumen, a second lumen and a third lumen inside; the insertion tube has an insertion tube lumen inside and a flow guide hole on the outer wall, which is communicated with the insertion tube lumen; the elastic connecting tube is communicated with the first lumen and the insertion tube lumen; the air bag tube is sleeved outside the elastic connecting tube and connected between the main tube and the insertion tube. In the initial state, the outer wall of the air bag tube is basically flush with the outer walls of the main tube and the insertion tube; after being inserted in place, water is injected into the air bag tube, and the air bag tube is inflated; when the main tube is pulled by mistake, the elastic connecting tube is quickly elongated, the outer diameter of the air bag tube is quickly reduced, and the water inside the air bag tube is quickly overflowed through the flow valve. The self-pressure relief safety catheter can reduce the extrusion of the air bag tube on the urethral mucosa, avoid the occurrence of serious complications such as urethral injury or tearing caused by accidental pulling of the catheter, and improve the safety and reliability of the catheter use.

The invention discloses a tracheal catheter special for upper gastrointestinal endoscopic surgery, which comprises an inner tube, an outer tube capable of sliding up and down with the inner tube is sleeved outside the inner tube, the top end of the outer tube is fixedly connected with the inner tube through a fixing knob, a respirator joint is arranged at the top end of the inner tube, an inner tube water bag is arranged at the bottom of the inner tube, and an outer tube water bag is arranged at the bottom of the inner tube. An inner tube suction hole is formed in one side of the inner tube water bag, and a Murphy hole is formed in the position, located below the inner tube water bag, of the bottom of the inner tube. The problems that in an upper gastrointestinal endoscopic surgery in the prior art, the exposed part of the tracheal catheter affects surgical operation, the cuff of the tracheal catheter compresses a surgical site or affects taking out of a specimen, the tracheal catheter rubs with an endoscope and is prone to disengagement to damage tracheal mucosa, and blood and secretions in the trachea are not sucked thoroughly are solved.

Methods for dissociating mucosa and submucosa from the muscularis propria from a region of the esophagus of a subject are disclosed. These methods include submucosally injecting into the esophagus of the subject a pharmaceutical composition comprising an extracellular matrix (ECM) hydrogel to form a cushion between the submucosa and the underlying muscularis propria in the region of the esophagus, the ECM hydrogel having the following characteristics: a) a time to 50% gelation of less than 30 minutes at a temperature of about 37°C, b) a flow viscosity suitable for injection into the esophagus, and c) a stiffness of about 10 to about 400 Pascals (Pa). The ECM hydrogel is not a bladder ECM hydrogel.

The invention relates to the technical field of medical instruments, in particular to a portable visual nasal gastrointestinal nutrition tube indwelling device which comprises an operation handle, an endoscope assembly, a guide wire and a shaping mechanism, and the endoscope assembly is connected to the operation handle, can be controlled by the operation handle and is used for checking conditions in the body of a patient; the endoscope assembly is sleeved with the nasal gastrointestinal nutrition tube when the nasal gastrointestinal nutrition tube is installed. The guide wire is inserted into the endoscope assembly and is used for supporting the endoscope assembly; the shaping mechanism is configured to enable the section shape of the nasal gastrointestinal nutrition tube with the curvature larger than a preset value to be recovered to be round and can also fix the shape of the nasal gastrointestinal nutrition tube with the curvature larger than the preset value. Therefore, on one hand, it can be guaranteed that the section of the nasal gastrointestinal nutrition tube is round and the blocking risk is avoided when the nasal gastrointestinal nutrition tube conveys nutrient solution or medicine, and on the other hand, elastic reset force generated at the bent position of the nasal gastrointestinal nutrition tube can be offset and the nasal gastrointestinal nutrition tube is prevented from continuously jacking mucous membranes and tissues in the human body.

The invention provides a positioning device for an alimentary canal lesion endoscope, and relates to the technical field of alimentary canal endoscopes, the positioning device comprises an endoscope pipeline, an adjusting mechanism facilitating adjustment is arranged on the endoscope pipeline, a supporting mechanism facilitating positioning is arranged on the endoscope pipeline, and the adjusting mechanism comprises a protective hollow column and a mounting column; the supporting mechanism comprises an endoscope probe, a first adjusting pipe and a suction cup, the protective hollow column is slidably mounted at the circumferential end of the endoscope pipeline, and the mounting column is fixedly mounted at the circumferential end of the endoscope pipeline. By arranging the umbrella type supporting structure composed of the first adjusting tube, the second adjusting tube and the universal joint, the actual interior of the digestive tract is not a flat environment, natural wrinkles exist on the stomach wall, the intestinal mucosa fluctuates in a concave-convex mode, and individual differences exist in the forms of the digestive tracts of different patients; the multi-point supporting design of the umbrella type structure enables a plurality of supporting point positions to be respectively attached to mucous membranes at different positions around the focus.

The present application belongs to the technical field of oral care, and particularly relates to an oral care composition and a preparation method thereof. The oral care composition comprises, by mass percentage, chitosan oligosaccharide 0.1-0.3%, sea hao polysaccharide 0.08-0.14%, forskolin 0.07-0.12%, corn sprout extract 0.05-0.09%, thickening agent 1-3%, humectant 40-50%, and the balance being water. The oral care composition of the present application can effectively inhibit the activity of glucosyltransferase, inhibit the production of dextran, interfere with the formation process of dental plaque, and reduce the adhesion sites of pathogenic bacteria in the oral cavity. In addition, the composition of the present application can promote the proliferation and repair of oral mucosa epithelial cells, and help repair oral mucosa damage. Furthermore, the use of each component in the composition of the present application can balance the oral microbial flora, while achieving the effect of inhibiting pathogenic bacteria and improving the oral environment.

The invention relates to the technical field of immunology, in particular to a haemophilus parasuis disease mucosal vaccine as well as a preparation method and application thereof.The haemophilus parasuis disease mucosal vaccine comprises serum type 4 haemophilus parasuis H0040LV4 and serum type 5 haemophilus parasuis H0014LV5 which are preserved in the China Center for Type Culture Collection (CCTCC) on November 10, 2025 and numbered as CCTCC M 20252516 and CCTCC M 20252517; the bivalent haemophilus parasuis bivalent outer membrane vesicle vaccine prepared by secreting outer membrane vesicles has a good immune protection effect on serum type 4 and type 5 haemophilus parasuis, and compared with a control group, pathological changes of tissues such as lungs and livers of a vaccine immune group are obviously relieved. The vaccine has good immunogenicity, can stimulate comprehensive immune response, induce the organism to generate remarkable specific mucosal immunity, and simultaneously induce cellular immunity and humoral immunity response, and has a wide application prospect.