Controlled-specimen-sampling oral devices are described, implanted or inserted into an 
oral cavity, built onto a prosthetic 
tooth crown, a denture plate, braces, a 
dental implant, or the like. The devices are replaced as needed. The controlled specimen sampling may be passive, based on a 
dosage form, or electro-mechanically controlled, for a high-precision, intelligent, specimen sampling. Additionally, the controlled sampling may be any one of the following: sampling in accordance with a preprogrammed 
regimen, sampling at a controlled rate, delayed sampling, pulsatile sampling, chronotherapeutic sampling, closed-loop sampling, responsive to a sensor's input, sampling 
on demand from a personal 
extracorporeal system, sampling 
regimen specified by a personal 
extracorporeal system, sampling 
on demand from a monitoring center, via a personal 
extracorporeal system, and sampling 
regimen specified by a monitoring center, via a personal extracorporeal system. 
Specimen collection in the 
oral cavity may be assisted or induced by a transport mechanism, such as any one of, or a combination of 
iontophoresis, electroosmosis, 
electrophoresis, 
electroporation, sonophoresis, and 
ablation. The oral devices require replacement at relatively long intervals of weeks or months. The oral devices and methods for controlled specimen sampling apply to humans and animals.