The invention relates to a layered
drug-loading microneedle patch as well as a preparation method and application thereof. The preparation method of the layered
drug-loading microneedle patch comprises the following steps: S1, dissolving a
drug and a soluble high-molecular
polymer in a
solvent according to a
mass ratio of (2: 1)-(1: 12) to form a needle tip solution, then filling a needle tip cavity of a microneedle mold with the needle tip solution,
drying, and removing redundant drug residues on the surface to form a drug-loading needle tip layer; and S2, filling a mold containing the drug-loading needle tip layer with a photocurable
polymer, performing
ultraviolet curing for 10-30 seconds under the
wavelength of 365-405 nm, and then performing demolding to form a substrate layer, thereby obtaining the layered drug-loading microneedle patch. According to the method, one-time filling of the needle tip part is successfully achieved by combining needle tip auxiliary material proportion optimization, meanwhile, the curing process is rapid, the
medicine utilization rate and the process stability are remarkably improved, the
medicine stability is good, and the method is suitable for industrial production.