40 results about "Connective tissue" patented technology

The invention discloses a mutton quality index intelligent hyperspectral image detection method, and belongs to the technical field of hyperspectral image detection.The mutton quality index intelligent hyperspectral image detection method comprises the steps that the surface of a mutton sample is scanned by rotating a polarized light source, and a muscle fiber four-direction light field matrix is generated. A three-dimensional muscle fiber topological graph is constructed, Gaussian curved surface fitting and iterative optimization of an energy function are combined, segmentation precision and robustness of geometric modeling are remarkably improved, reliability and multi-scale adaptability of muscle fiber spatial distribution analysis are improved, and by fusing the sarcomedo contraction state, intermuscular fat marks and metabolic activity, the segmentation accuracy is improved. And a tenderness-freshness comprehensive decision is generated through dynamic weight distribution and a nonlinear scoring formula, so that multi-dimensional data complementation is realized, and the comprehensiveness and automatic decision-making capability of quality grading are improved.

The invention relates to the technical field of intelligent medical treatment, and discloses a connective tissue disease related lung disease early screening method and system based on deep learning, and the method comprises the steps: obtaining clinical data, a high-resolution chest CT image and biomarker data of a to-be-screened target; the clinical data, the high-resolution chest CT image and the biomarker data are input into a deep learning feature extraction and fusion module, high-dimensional clinical features, image feature vectors and biomarker time sequence feature vectors are extracted and fused, and fused feature vectors are obtained; and inputting the fusion feature vector into an early screening and typing module, and outputting a lung abnormal risk detection result. According to the application, the effects of early diagnosis of connective tissue disease related lung diseases and timely intervention can be achieved.

The invention relates to the technical field of functional drinks, in particular to a polypeptide synergistically strengthened cubilose collagen composite drink with a breast enlarging function and a preparation method of the polypeptide synergistically strengthened cubilose collagen composite drink. The drink contains fish collagen tripeptide, elastin peptide, cubilose peptide, pueraria mirifica isoflavone, red clover isoflavone and saffron crocus extract. A lipidosome delivery system is adopted to entrap polypeptide to form a nano-scale compound, nano-emulsion entraps phytoestrogen, and berry polyphenol and lipidosome-polypeptide form a stable ternary compound. Through the multi-way synergistic effect that phytoestrogen activates a mammary gland estrogen receptor, polypeptide promotes connective tissue collagen synthesis and cubilose peptide activates a growth factor signal, mammary gland development is remarkably promoted, the breast enlarging effect is achieved, the bioavailability reaches 85% or above, and the retention rate of active ingredients stored at normal temperature for 24 months is larger than 90%.

The application discloses application of a heteroterpene compound I in preparation of a heart failure resisting drug. The heteroterpene compound I is obtained by separation and purification from a marine fungus Aspergillus terreus GZU-311, and is used to treat a mouse heart failure model induced by adriamycin or left anterior descending coronary artery ligation, and it is found that the heteroterpene compound I can improve the heart function of the mouse, reduce myocardial cell damage, inhibit myocardial connective tissue thickening, improve myocardial cell arrangement disorder, reduce inflammatory cell infiltration, and has an effect of resisting heart failure. Therefore, the application provides application of the heteroterpene compound I in preparation of a heart failure resisting drug. The application enriches drug source molecules that can be used for treating heart failure, and is helpful to development of an anti-heart failure drug and clinical treatment.

A wireless augmented reality (AR) system for use by medical practitioners during diagnostic, surgical, or interventional procedures is disclosed. The system includes AR eyewear with integrated heads-up displays (HUDs) embedded in semi-transparent optical lenses, enabling video content to be projected without obstructing the user's natural field of view. Each lens includes a high-resolution micro display and an ambient light sensor for automatic brightness adjustment. The eyewear is coupled via a wired connection to a portable control unit containing a microprocessor for real-time decoding and formatting video signals. A wireless transmitter connects to a medical video source and transmits the live feed to the control unit via a high-bandwidth wireless protocol. The system enables projection of anatomical overlays in real-time, supporting visualization of muscle tissue, nerves, tendons, connective structures, and any other human or animal body part.

The present invention provides a method and composition for treating a disease, wherein the disease is a condition and / or disease of diffuse connective tissue disease. The invention also provides an MHC deficient modified immune cell and a polynucleotide targeting the cell.

An optimized dental implant system comprising: - at least one dental implant; - at least one customized post; - at least one healing cap made of PMMA or PEEK having a locking taper and a flared lower portion, configured to be fully inserted into and interlocked with the post; and - at least one capsule or temporary crown made of PEEK or PMMA, which can be fixed to the post using the cap. The post comprises: - a first subgingival portion having vestibular, mesial, distal, and palatal surfaces, adapted to allow for the maturation of connective tissue attachment and juxitation; and - a second subgingival portion having a height adapted to the patient's occlusal height.

The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a medicinal use thereof, and a method for preparing the same. The novel compounds according to the present invention, stereoisomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; endocrinopathy; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, or chromosomal aberration.

The application belongs to the technical field of biological medicine, and is especially an immune cell separation filtering liquid filtering device. The device comprises a filter barrel, a liquid outlet pipe installed at the bottom of the filter barrel, a liquid inlet pipe arranged on the outer sidewall of the filter barrel, and a filtering assembly installed in the filter barrel. The liquid inlet pipe is obliquely arranged, so that the filtering liquid enters from the tangent direction, forms a cyclone flow, and flows down along the inner wall of the filter barrel under the action of centrifugal force. The filtering liquid with large viscosity connective tissue on the surface of the filter barrel is flushed into the sewage pipe, the L-shaped scraper is rotated to scrape off the connective tissue with large viscosity adhered to the surface of the filter barrel to the bottom surface of the filter barrel, the filter barrel mesh hole is prevented from being blocked, the screw block drives the sliding sleeve to slide upward on the surface of the guide rod, and the sealing cover is lifted away from the surface of the filter barrel. The filter barrel is arranged on the outer surfaces of the two L-shaped mounting plates through bolt connection, so that the filter barrel can be easily removed from the inside of the filter barrel.

The invention relates to the technical field of food processing, and discloses a dry-fried chicken accessory and a preparation process thereof, and the preparation process comprises the following steps: raw material pretreatment, tenderization treatment, seasoning and pickling, pre-dehydration treatment, grease pretreatment, dry frying process, sterilization and packaging. According to the method disclosed by the invention, aiming at the differences of various accessory parts of the chicken heart, the chicken gizzards, the chicken liver and the chicken intestines in tissue structures and textures, the tenderization liquid containing the specific compound enzyme preparation is used for carrying out synergistic treatment, and protease from different sources acts on different protein components to degrade connective tissues and myofibrils; the activity and action sites of protease are further adjusted through participation of calcium ions and organic acid, so that tenacious chicken gizzards and chicken hearts and relatively tender chicken livers and chicken intestines can synchronously achieve ideal tenderization effects, the taste uniformity and overall tenderness of the final product are improved, and the problem that part of raw materials are dry, hard, soft and rotten is avoided.

Surgical tools and kits for performing methods include a grommet with cylindrical shaft, cutting tip, annular flange with suture retaining anchoring fixture; a grommet jig for extending between adjacent grommets and guiding a needle therebetween; a family of needles with single and double pointed ends, reinforced eyelets, stops to limit inadvertent exiting, double shaft construction with a longitudinal gap and sharpened, slicing ends, including a “J” shape embodiment; a bone anchor with ring to secure sutures about a patient's clavicle; a tissue dissector having radially extending cones to nick taut connecting tissues; a tissue rasp having a series of crisscrossing grooves along an end; a tissue mesher comprising one or more blocks having a matrix of holes for clamping a plurality of needles and a supporting framework; and a kit device and a method of surgically inserting an internal mesh brassiere under the breast skin.

The application relates to the technical field of stress urinary incontinence treatment, and particularly discloses a traditional Chinese medicine composition for treating stress urinary incontinence, which is composed of the following raw medicinal materials in a weight ratio: 15g of raw astragalus, 15g of codonopsis, 15g of salvia miltiorrhiza, 10g of raspberry, 10g of immature bitter orange and 6g of bupleurum. The application is strictly designed according to a single-arm, single-center, clinical retrospective research, and an internationally commonly used urinary incontinence outcome index determination standard. The test result shows that, at the end of 4 weeks of treatment, 69 sample results show that the Qishizhiyi recipe combined with pelvic floor muscle training can significantly reduce the ICI-Q-SF score, the number of 24h urinary incontinence, and improve the I-QOL score, and the total effective rate reaches 89.86%, and there is no obvious toxic side effect. Through basic animal experiment research, it is shown that the Qishizhiyi recipe can significantly reduce collagen degradation, regulate hormone levels, reduce oxidative stress damage and inhibit cell apoptosis, and from the basic aspect, it is confirmed that the Qishizhiyi recipe has the effects of regulating connective tissue factors and hormone levels and inhibiting cell apoptosis.

This invention provides the application of human protocadherin 18 (PCDH18) as a biomarker in the preparation of products for the diagnosis, auxiliary diagnosis, or progression prediction of antiphospholipid syndrome (APS), belonging to the field of in vitro diagnostic technology. In this invention, detecting serum PCDH18 levels in patients is helpful in diagnosing APS and is specific to this disease, and can be used to differentiate APS from other connective tissue diseases. Furthermore, APS patients have higher serum PCDH18 levels compared to asymptomatic aPL-positive patients. Therefore, PCDH18 testing in aPL-positive individuals is helpful for the early diagnosis and intervention of APS. Additionally, serum PCDH18 levels in OAPS patients are significantly higher than in TAPS patients, suggesting that PCDH18 can serve as a biomarker for differentiating or assisting in the differentiation of TAPS and OAPS.

Disclosed are systems, devices and methods for laser microporation for rejuvenation of tissue of the eye, for example, regarding aging of connective tissue and rejuvenation of connective tissue by scleral rejuvenation. The systems, devices and methods disclosed herein restore physiological functions of the eye including restoring physiological accommodation or physiological pseudo-accommodation through natural physiological and biomechanical phenomena associated with natural accommodation of the eye. In some embodiments, the laser system may be configured to treat ocular tissue off axis or in a region of the eye which is distinct from the visual axis or directed away from the pupil of the eye where the gaze of the eye is.

The invention relates to the technical field of medical image processing, and discloses a breast X-ray photography auxiliary diagnosis system based on feature image selective area fusion. Comprising an image acquisition module used for acquiring a mammary gland X-ray tomographic image; the feature recognition module is used for performing feature recognition and marking on breast cancer calcification points, radial structures and circular focus high-density shadows in the breast X-ray tomographic image by using a deep learning method; the selected area fusion module is used for carrying out image synthesis on the key selected area according to the feature recognition and marking result, obtaining a synthesized image, reducing the absolute number of the images and keeping the diagnosis accuracy and sensitivity; and the three-dimensional positioning module is used for performing three-dimensional coordinate positioning on the synthesized image, outputting a focus position, dynamically optimizing 3D occupation of a focus in the synthesized image according to the focus position, analyzing and deeply learning a surrounding blood vessel and connective tissue density shadow, and outputting auxiliary diagnosis information.

The utility model discloses a rotary cutting tool bit structure convenient to penetrate through the compact texture of a flat drastic ladle, which comprises a horizontally arranged double-layer pipe structure, the double-layer pipe structure comprises an outer pipe body and a rotary tool bit, the rotary tool bit is connected with a driving mechanism for driving the rotary tool bit to rotate and is communicated with a negative pressure liposuction machine, and the negative pressure liposuction machine is communicated with the outer pipe body. The end, penetrating into the skin, of the double-layer tube structure is a front end face which is an inclined face, a plurality of first through holes are formed in the position, close to the front end face, of the rotary tool bit in a staggered mode, and second through holes are correspondingly formed in the positions, corresponding to the first through holes, of the outer tube body. According to the utility model, the front end face penetrating into the skin is changed from a plane to an inclined plane, which is more beneficial to penetrating through compact fibrous connective tissues in a drastic bag, and the operation process is more time-saving and labor-saving. The multiple first through holes and the multiple second through holes are formed, so that subcutaneous tissue can be sucked from multiple different angles to be smashed by the rotary cutter head, the situation that the tissue is uneven due to only one inlet is avoided, the adsorption efficiency is high in the final operation process, and tissue treatment is smooth.

This invention discloses a method for extracting sturgeon roe for caviar production. The method involves obtaining target sturgeon and determining the optimal processing time window for the target sturgeon; performing a first low-temperature pretreatment on the raw roe mass to lower its center temperature to a first target temperature range; performing rinsing and grading operations on the initially separated roe mixture to remove impurities and separating the roe into at least two grades based on particle size, obtaining roe of each grade to be cured; draining at least one grade of roe to be cured, followed by salting, and completing all steps from slaughter to salting within a second preset time period to obtain primary sturgeon roe for caviar production. This invention employs a low-temperature pretreatment combined with a suitable temperature-controlled roe-rolling process, which promotes the separation of roe from connective tissue and significantly reduces the risk of mechanical damage, thus helping to maintain the integrity of the roe particles.

The invention provides a compound for treating connective tissue diseases and a pharmaceutical composition thereof. Specifically, the invention provides application of a compound shown as a formula I or pharmaceutically acceptable salt thereof in preparation of a pharmaceutical composition for preventing or treating connective tissue diseases.

The present disclosure provides anti-BlyS antibodies for use in the treatment of connective tissue diseases, particularly connective tissue disease-associated interstitial lung diseases, including systemic sclerosis, particularly systemic sclerosis-associated interstitial lung diseases, such as diffuse skin systemic sclerosis-associated interstitial lung diseases. Also provided are methods of treating connective tissue disease associated interstitial lung disease, including systemic sclerosis associated interstitial lung disease, comprising administering to a subject in need thereof a therapeutically effective amount of an anti-BlyS antibody.

Disclosed are systems, devices and methods for laser microporation for rejuvenation of tissue of the eye, for example, regarding aging of connective tissue and rejuvenation of connective tissue by scleral rejuvenation. The systems, devices and methods disclosed herein restore physiological functions of the eye including restoring physiological accommodation or physiological pseudo-accommodation through natural physiological and biomechanical phenomena associated with natural accommodation of the eye. In some embodiments, the laser system may be configured to treat ocular tissue off axis or in a region of the eye which is distinct from the visual axis or directed away from the pupil of the eye where the gaze of the eye is.

To provide a tissue structure that facilitates administration of pluripotent stem cells to a disease site, and a method for forming the tissue structure.SOLUTION: A tissue structure formed by a partition wall 12 indwelled in an environment including a biological tissue, wherein the partition wall 12 includes an inner surface 14 surrounding a hollow portion 11 and a plurality of through-holes 13 opened in the inner surface 14, cells in the biological tissue enter the hollow portion 11 through the through-holes to form the tissue structure in the hollow portion 11, and the tissue structure includes a membranous fibrous connective tissue having one side surface peeled from the inner surface 14 and a sparse fibrous tissue spreading over the entire other side surface opposite to the one side surface and having pluripotent stem cells accumulated therein.SELECTED DRAWING: Figure 1

The application relates to the field of implant technology, and particularly relates to a multi-stage structure zirconium oxide abutment for regulating and controlling soft tissue sealing around an implant abutment, a cross section of the zirconium oxide abutment is an inverted isosceles trapezoid, the height of the upper half of the zirconium oxide abutment is 1-2 mm, the height of the lower half of the zirconium oxide abutment is 1-2.5 mm, the outer side surface of the lower half is uniformly distributed with a plurality of funnel-shaped blind holes, the top diameter of the blind holes is 50-150 microns, the bottom diameter is 30-50 microns, the depth is 10-200 microns, and the porosity is 10-60%. The multi-stage structure implant zirconium oxide abutment regulates and controls the attachment length of epithelium and connective tissue by using multi-stage structure design, is closer to the natural tooth structure, and improves long-term stability of implant restoration.

The utility model discloses a flow guide stent for glaucoma surgery, belongs to the technical field of stents for eye surgery, and aims to solve the problem that the existing stent is single in outflow passage and easy to block. The whole support frame body is fixed around an eyeball through the suture hole and the communicating assembly, the stability of the whole support frame body is improved, the slipping condition is avoided, the opening is communicated with the open cavity of the periorbital iris valve, when intraocular pressure is too high and the amount of aqueous humor is large, the aqueous humor enters the opening through the open cavity, and the intraocular pressure is reduced. The aqueous humor enters the interior of the diversion trench B along the diversion trench A and is finally diffused through the guide-out groove, the number of reserved channels of the aqueous humor is increased, the aqueous humor is evenly released, the blocking situation caused by the single outflow channel of the support frame body is avoided, and the aqueous humor is evenly distributed on the outer side of the bottom pad under the action of pressure difference and can be conveniently absorbed through surrounding connective tissue.

Dental prosthesis element comprising a microstructured surface and a surface treatment. Dental prosthesis element (1) comprising a body (4) having a microstructured surface (14), and a coating (15) covering the microstructured surface, the coating being intended to come into contact with epithelial tissue (12) and / or connective tissue (13), the coating comprising zirconium nitride. Figure for abbreviation: Figure 1

A use of a meroterpenoid compound I in the preparation of a heart failure prevention drug. By using a meroterpenoid compound I isolated and purified from the marine fungus Aspergillus terreus GZU-311 to treat mouse heart failure models induced by doxorubicin, left anterior descending coronary artery ligation, or angiotensin II, it was found that the meroterpenoid compound I can improve cardiac function in mice, reduce cardiomyocyte injury, inhibit myocardial connective tissue thickening, improve disordered arrangement of cardiomyocytes, and reduce inflammatory cell infiltration, thereby having a heart failure prevention effect. Accordingly, the use of the meroterpenoid compound I in the preparation of a heart failure prevention drug is provided. The drug source molecules that can be used for treating heart failure are enriched, which is helpful for the development of heart failure prevention drugs and clinical treatment using same.

A device for performing a cosmetic or medical procedure and methods of operating such a device are usable for treating fibrous adhesions, such as those implicated in the formation of cosmetic or medical conditions including but not limited to cellulite. Embodiments of the disclosure have been particularly developed for targeting and disrupting fibrous adhesions to restore or improve normal physiological tissue function and / or aesthetic appearance. In at least one embodiment, the device comprises an elongate body and one or more user controllable breaking means. Each breaking means is actuatable to move between a retracted position in which the breaking means is in a collapsed configuration and an operative position in which the breaking means is in an expanded configuration suitable to break a strand of fibrous material or fibrous connective tissue.

Surgical tools and kits for performing methods include a grommet with cylindrical shaft, cutting tip, annular flange with suture retaining anchoring fixture; a grommet jig for extending between adjacent grommets and guiding a needle therebetween; a family of needles with single and double pointed ends, reinforced eyelets, stops to limit inadvertent exiting, double shaft construction with a longitudinal gap and sharpened, slicing ends, including a “J” shape embodiment; a bone anchor with ring to secure sutures about a patient's clavicle; a tissue dissector having radially extending cones to nick taut connecting tissues; a tissue rasp having a series of crisscrossing grooves along an end; a tissue mesher comprising one or more blocks having a matrix of holes for damping a plurality of needles and a supporting framework; and a kit device and a method of surgically inserting an internal mesh brassiere under the breast skin.

The invention discloses a preparation method and application of a gelatin / sodium alginate / mesoporous bioactive glass composite guided bone tissue regeneration membrane, and the preparation method comprises the following steps: (1) respectively dissolving gelatin, sodium alginate and mesoporous bioactive glass in pure water, mixing, and degassing in vacuum; and (2) carrying out membrane casting molding on the degassed homogeneous mixed solution, and sequentially carrying out condensation, ion and chemical crosslinking, cleaning and freeze drying to obtain the regenerated membrane. The prepared regeneration membrane has a compact surface layer and can effectively inhibit penetration of fibrous connective tissues; meanwhile, proper roughness is achieved, and cell adhesion and bone surface osteogenesis are facilitated. The membrane has good mechanical performance, biocompatibility, barrier performance, controllable degradation rate and excellent osteogenesis performance, and can effectively promote bone regeneration and defect repair while obstructing soft tissue growth. In addition, the medicine is wide in raw material source, simple in preparation process, mild in condition and low in cost, and has a remarkable clinical application prospect.

The invention discloses a weak alkaline water preparation device capable of simulating a natural mineralization process, and belongs to the field of weak alkaline water preparation, the weak alkaline water preparation device comprises a mounting rack, a plurality of multi-medium filtering tanks are arranged at the inner bottom of the mounting rack, the tops of the multi-medium filtering tanks are fixedly connected with connecting pipes, one side of the inner bottom of the mounting rack is fixedly connected with a disinfection tank, and the disinfection tank is fixedly connected with a water storage tank. And the other side of the inner bottom of the mounting frame is fixedly connected with a water pump, and a monitoring unit is arranged in the middle of the front side of the mounting frame. Water flow can enter the rotating sleeve through the open groove and then enter the material containing bin through the second water inlet and the first screen frame, the water flow makes full contact with the composite strontium-metasilicic acid filter material in the material containing bin, the composite strontium-metasilicic acid filter material can release strontium, metasilicic acid and other microelements, the mineral water standard is met, and the mineral water quality is improved. The composition promotes elasticity of cartilage and connective tissue, accelerates bone calcification, prevents and treats osteoporosis, and avoids osteoporosis caused by long-term taking of RO.