61 results about "Connective tissue" patented technology

The invention discloses a mutton quality index intelligent hyperspectral image detection method, and belongs to the technical field of hyperspectral image detection.The mutton quality index intelligent hyperspectral image detection method comprises the steps that the surface of a mutton sample is scanned by rotating a polarized light source, and a muscle fiber four-direction light field matrix is generated. A three-dimensional muscle fiber topological graph is constructed, Gaussian curved surface fitting and iterative optimization of an energy function are combined, segmentation precision and robustness of geometric modeling are remarkably improved, reliability and multi-scale adaptability of muscle fiber spatial distribution analysis are improved, and by fusing the sarcomedo contraction state, intermuscular fat marks and metabolic activity, the segmentation accuracy is improved. And a tenderness-freshness comprehensive decision is generated through dynamic weight distribution and a nonlinear scoring formula, so that multi-dimensional data complementation is realized, and the comprehensiveness and automatic decision-making capability of quality grading are improved.

The invention relates to the technical field of intelligent medical treatment, and discloses a connective tissue disease related lung disease early screening method and system based on deep learning, and the method comprises the steps: obtaining clinical data, a high-resolution chest CT image and biomarker data of a to-be-screened target; the clinical data, the high-resolution chest CT image and the biomarker data are input into a deep learning feature extraction and fusion module, high-dimensional clinical features, image feature vectors and biomarker time sequence feature vectors are extracted and fused, and fused feature vectors are obtained; and inputting the fusion feature vector into an early screening and typing module, and outputting a lung abnormal risk detection result. According to the application, the effects of early diagnosis of connective tissue disease related lung diseases and timely intervention can be achieved.

The invention discloses a high-pressure pulse meat flushing device, which relates to the technical field of meat processing, and comprises a cleaning treatment box, a top rotating ring rail groove frame, a bottom annular guide rail, a vertical linear guide rail, a side screw rod guide rail and a high-pressure pulse flushing adjusting assembly, under the cooperation of the high-pressure pulse flushing adjusting assembly, a picking piece or a shifting piece is adopted as an auxiliary cleaning tool on the whole, special parts such as fascia, connective tissue, hair and a grease layer of meat can be treated, better cleaning conditions are created for high-pressure pulse water flow, and the cleaning efficiency is improved. And the cavitation effect of ultrasonic waves is combined with high-pressure pulse water flow flushing, so that meat can be cleaned from inside and outside at the same time, the cleaning effect is greatly improved, and the cleaning efficiency and quality are improved.

The invention relates to the technical field of functional drinks, in particular to a polypeptide synergistically strengthened cubilose collagen composite drink with a breast enlarging function and a preparation method of the polypeptide synergistically strengthened cubilose collagen composite drink. The drink contains fish collagen tripeptide, elastin peptide, cubilose peptide, pueraria mirifica isoflavone, red clover isoflavone and saffron crocus extract. A lipidosome delivery system is adopted to entrap polypeptide to form a nano-scale compound, nano-emulsion entraps phytoestrogen, and berry polyphenol and lipidosome-polypeptide form a stable ternary compound. Through the multi-way synergistic effect that phytoestrogen activates a mammary gland estrogen receptor, polypeptide promotes connective tissue collagen synthesis and cubilose peptide activates a growth factor signal, mammary gland development is remarkably promoted, the breast enlarging effect is achieved, the bioavailability reaches 85% or above, and the retention rate of active ingredients stored at normal temperature for 24 months is larger than 90%.

The present disclosure relates to methods of treating Sjogren's syndrome or mixed connective tissue disease using a compound of formula (I) or a pharma- ceutically acceptable salt thereof. Also disclosed herein are compounds of formula (I) or a pharma- ceutically acceptable salt thereof for treating patients with Sjogren's syndrome or mixed connective tissue disease, as well as medicaments, dosing regimens, pharmaceutical formulations, dosage forms and kits for use in the disclosed uses and methods.

The application discloses application of a heteroterpene compound I in preparation of a heart failure resisting drug. The heteroterpene compound I is obtained by separation and purification from a marine fungus Aspergillus terreus GZU-311, and is used to treat a mouse heart failure model induced by adriamycin or left anterior descending coronary artery ligation, and it is found that the heteroterpene compound I can improve the heart function of the mouse, reduce myocardial cell damage, inhibit myocardial connective tissue thickening, improve myocardial cell arrangement disorder, reduce inflammatory cell infiltration, and has an effect of resisting heart failure. Therefore, the application provides application of the heteroterpene compound I in preparation of a heart failure resisting drug. The application enriches drug source molecules that can be used for treating heart failure, and is helpful to development of an anti-heart failure drug and clinical treatment.

A wireless augmented reality (AR) system for use by medical practitioners during diagnostic, surgical, or interventional procedures is disclosed. The system includes AR eyewear with integrated heads-up displays (HUDs) embedded in semi-transparent optical lenses, enabling video content to be projected without obstructing the user's natural field of view. Each lens includes a high-resolution micro display and an ambient light sensor for automatic brightness adjustment. The eyewear is coupled via a wired connection to a portable control unit containing a microprocessor for real-time decoding and formatting video signals. A wireless transmitter connects to a medical video source and transmits the live feed to the control unit via a high-bandwidth wireless protocol. The system enables projection of anatomical overlays in real-time, supporting visualization of muscle tissue, nerves, tendons, connective structures, and any other human or animal body part.

The present invention provides a method and composition for treating a disease, wherein the disease is a condition and / or disease of diffuse connective tissue disease. The invention also provides an MHC deficient modified immune cell and a polynucleotide targeting the cell.

A method for determining whether a subject is at risk of developing a musculoskeletal and / or connective tissue disease.

The invention pertains to the field of pharmacology and medicine, specifically to the use of the IL-6 inhibitor olokizumab for the treatment of progressive fibrotic interstitial lung diseases (ILDs), including idiopathic pulmonary fibrosis, non-specific interstitial pneumonia, lymphocytic interstitial pneumonia, unclassifiable idiopathic interstitial pneumonia, hypersensitivity pneumonitis (allergic alveolitis), sarcoidosis; interstitial pneumonia with autoimmune features; pneumoconioses; pulmonary histiocytosis; interstitial lung disease associated with autoimmune diseases, such as systemic sclerosis; rheumatoid arthritis; systemic lupus erythematosus; polymyositis / dermatomyositis; primary Sjögren's syndrome; mixed connective tissue disease; other systemic connective tissue diseases, as well as polymyalgia rheumatica and giant cell arteritis. This disclosure can be used for the effective therapy of progressive fibrotic ILDs, as polymyalgia rheumatica, and giant cell arteritis expanding the range of medications used to treat these conditions.

The invention discloses multi-pressure-sensitive adjusting type steak tenderization precision processing equipment, and relates to the technical field of steak tenderization, the multi-pressure-sensitive adjusting type steak tenderization precision processing equipment comprises a machine body, a lifting mechanism is arranged in the machine body, a driving mechanism is arranged at the top of the lifting mechanism, and a cutting mechanism is arranged at the bottom of the driving mechanism; and the cutting mechanism comprises a movable seat, a first pressing rod, a second pressing rod, a connecting block and a tension spring. The lifting height of an electric telescopic rod is controlled through a pressure sensor, the cutting pressure can be adjusted, it is ensured that beef steaks can be processed according to the preset tenderization degree, the conveying mechanism drives multiple sets of connecting plates through chain transmission, uniform conveying of the beef steaks is achieved, and different pressing rods in the cutting mechanism are matched, so that the cutting efficiency is improved. Muscle fibers and connective tissues are subjected to multidirectional damage by utilizing high-frequency reciprocating cutting action, the problem of uneven tenderization caused by single-direction treatment is avoided, and the technical problems that traditional equipment cannot dynamically adapt to the size of the steak, the tenderization depth is uncontrollable and water-wind treatment separation is caused are solved.

An optimized dental implant system comprising: - at least one dental implant; - at least one customized post; - at least one healing cap made of PMMA or PEEK having a locking taper and a flared lower portion, configured to be fully inserted into and interlocked with the post; and - at least one capsule or temporary crown made of PEEK or PMMA, which can be fixed to the post using the cap. The post comprises: - a first subgingival portion having vestibular, mesial, distal, and palatal surfaces, adapted to allow for the maturation of connective tissue attachment and juxitation; and - a second subgingival portion having a height adapted to the patient's occlusal height.

The invention relates to an alginic acid-glucosamine-calcium-collagen peptide complex with a three-component synchronous slow release effect as well as a large-scale preparation method and application of the alginic acid-glucosamine-calcium-collagen peptide complex. The preparation method comprises the following steps: preparing collagen peptide purified by anion exchange chromatography / resin by taking animal connective tissue as a raw material; preparing glucosamine hydrochloride by taking squid cartilage as a raw material, adding a calcium chloride solution, and stirring at constant temperature to complete a first complexation reaction to obtain a glucosamine-calcium complex; then adding a collagen peptide solution purified by anion exchange chromatography / resin, and stirring at a constant temperature to complete a second complex reaction to obtain a glucosamine-calcium-collagen peptide complex; and finally adding a sodium alginate solution, stirring at a constant temperature to complete a third complexation reaction, and desalting through a nanofiltration membrane and spray-drying to obtain the alginic acid-glucosamine-calcium-collagen peptide complex. The complex can realize the synchronous slow-release effect of three components of glucosamine, calcium and collagen peptide for not less than 3 hours, and can prevent high-concentration sodium and chloride ions from hurting a human body.

The present invention relates to novel compounds having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, a medicinal use thereof, and a method for preparing the same. The novel compounds according to the present invention, stereoisomers thereof or pharmaceutically acceptable salts thereof have the histone deacetylase 6 (HDAC6) inhibitory activity, and are effective in preventing or treating HDAC6-related diseases, comprising infectious diseases; neoplasm; endocrinopathy; nutritional and metabolic diseases; mental and behavioral disorders; neurological diseases; eye and ocular adnexal diseases; circulatory diseases; respiratory diseases; digestive diseases; skin and subcutaneous tissue diseases; musculoskeletal system and connective tissue diseases; and teratosis or deformities, or chromosomal aberration.

The invention discloses a connective tissue hyperplasia excision mechanism, and relates to the technical field of medical instruments. Comprising a cutting mechanism body; the outer cutter assembly is fixedly arranged at one end of the cutting mechanism body, and the outer cutter assembly is provided with an inner cutter channel with an opening in one side; the inner knife assembly is arranged in the excision mechanism body, one end of the inner knife assembly can enter the inner knife channel, and the inner knife assembly rotationally cuts connective tissue hyperplasia at the opening position of the inner knife channel; the visual assembly comprises an imaging end and a lens, and the lens is fixed to one side of the outer cutter assembly and can transmit a real-time image of a cutting area to the imaging end. According to the connective tissue hyperplasia excision mechanism, the connective tissue hyperplasia excision effect can be improved.

The application belongs to the technical field of biological medicine, and is especially an immune cell separation filtering liquid filtering device. The device comprises a filter barrel, a liquid outlet pipe installed at the bottom of the filter barrel, a liquid inlet pipe arranged on the outer sidewall of the filter barrel, and a filtering assembly installed in the filter barrel. The liquid inlet pipe is obliquely arranged, so that the filtering liquid enters from the tangent direction, forms a cyclone flow, and flows down along the inner wall of the filter barrel under the action of centrifugal force. The filtering liquid with large viscosity connective tissue on the surface of the filter barrel is flushed into the sewage pipe, the L-shaped scraper is rotated to scrape off the connective tissue with large viscosity adhered to the surface of the filter barrel to the bottom surface of the filter barrel, the filter barrel mesh hole is prevented from being blocked, the screw block drives the sliding sleeve to slide upward on the surface of the guide rod, and the sealing cover is lifted away from the surface of the filter barrel. The filter barrel is arranged on the outer surfaces of the two L-shaped mounting plates through bolt connection, so that the filter barrel can be easily removed from the inside of the filter barrel.

The invention relates to the technical field of food processing, and discloses a dry-fried chicken accessory and a preparation process thereof, and the preparation process comprises the following steps: raw material pretreatment, tenderization treatment, seasoning and pickling, pre-dehydration treatment, grease pretreatment, dry frying process, sterilization and packaging. According to the method disclosed by the invention, aiming at the differences of various accessory parts of the chicken heart, the chicken gizzards, the chicken liver and the chicken intestines in tissue structures and textures, the tenderization liquid containing the specific compound enzyme preparation is used for carrying out synergistic treatment, and protease from different sources acts on different protein components to degrade connective tissues and myofibrils; the activity and action sites of protease are further adjusted through participation of calcium ions and organic acid, so that tenacious chicken gizzards and chicken hearts and relatively tender chicken livers and chicken intestines can synchronously achieve ideal tenderization effects, the taste uniformity and overall tenderness of the final product are improved, and the problem that part of raw materials are dry, hard, soft and rotten is avoided.

Surgical tools and kits for performing methods include a grommet with cylindrical shaft, cutting tip, annular flange with suture retaining anchoring fixture; a grommet jig for extending between adjacent grommets and guiding a needle therebetween; a family of needles with single and double pointed ends, reinforced eyelets, stops to limit inadvertent exiting, double shaft construction with a longitudinal gap and sharpened, slicing ends, including a “J” shape embodiment; a bone anchor with ring to secure sutures about a patient's clavicle; a tissue dissector having radially extending cones to nick taut connecting tissues; a tissue rasp having a series of crisscrossing grooves along an end; a tissue mesher comprising one or more blocks having a matrix of holes for clamping a plurality of needles and a supporting framework; and a kit device and a method of surgically inserting an internal mesh brassiere under the breast skin.

Provided are method and composition for treating disease, wherein the disease is a condition and / or a disease of a diffuse connective tissue disease. Also provided is a modified immune cell deficient in MHC and a polynucleotide targeting the same.

The application relates to the technical field of stress urinary incontinence treatment, and particularly discloses a traditional Chinese medicine composition for treating stress urinary incontinence, which is composed of the following raw medicinal materials in a weight ratio: 15g of raw astragalus, 15g of codonopsis, 15g of salvia miltiorrhiza, 10g of raspberry, 10g of immature bitter orange and 6g of bupleurum. The application is strictly designed according to a single-arm, single-center, clinical retrospective research, and an internationally commonly used urinary incontinence outcome index determination standard. The test result shows that, at the end of 4 weeks of treatment, 69 sample results show that the Qishizhiyi recipe combined with pelvic floor muscle training can significantly reduce the ICI-Q-SF score, the number of 24h urinary incontinence, and improve the I-QOL score, and the total effective rate reaches 89.86%, and there is no obvious toxic side effect. Through basic animal experiment research, it is shown that the Qishizhiyi recipe can significantly reduce collagen degradation, regulate hormone levels, reduce oxidative stress damage and inhibit cell apoptosis, and from the basic aspect, it is confirmed that the Qishizhiyi recipe has the effects of regulating connective tissue factors and hormone levels and inhibiting cell apoptosis.

To provide a tissue body forming device and a tissue body forming method for forming a connective tissue body efficiently in an environment whose size is limited.SOLUTION: A tissue body forming device includes a first partition member 11 and a second partition member 21. A plurality of first through-holes 14 penetrating from an exterior surface 13 to an interior surface 12 are formed in the first partition member 11. A groove 24 sandwiched by a groove side wall and having a groove opening 24A on the opposite surface 22 is formed in the second partition member 21. The opening dimensions of the first though-holes 14 are 0.02-2.5 mm. The depth of the first through-holes 14 is 0.1-2.0 mm. The ratio occupied by the opening of the first through-holes 14 in a unit area of the exterior surface 13 is 4-70%. The distance between the opposite surface 22 and the interior surface 12 is equal to or less than the width of the groove side wall, and is equal to or less than 0.5 mm. The groove 24 is communicated with the plurality of first through-holes 14.SELECTED DRAWING: Figure 1

The present invention relates to a closed intravenous set for administering an anticancer drug. The intravenous set comprises a spike, a drip chamber, and a tube to guide a medicinal fluid stored in an intravenous bag to be administered to a patient, wherein the spike and the drip chamber are separated from each other, the spike has a first connecting member at the lower end thereof, and the drip chamber has a second connecting member at the upper end thereof, which is detachably connected to the first connecting member. According to the present invention, safety can be ensured without the risk of leakage of the anticancer drug or infection that may occur during administration.

This invention provides the application of human protocadherin 18 (PCDH18) as a biomarker in the preparation of products for the diagnosis, auxiliary diagnosis, or progression prediction of antiphospholipid syndrome (APS), belonging to the field of in vitro diagnostic technology. In this invention, detecting serum PCDH18 levels in patients is helpful in diagnosing APS and is specific to this disease, and can be used to differentiate APS from other connective tissue diseases. Furthermore, APS patients have higher serum PCDH18 levels compared to asymptomatic aPL-positive patients. Therefore, PCDH18 testing in aPL-positive individuals is helpful for the early diagnosis and intervention of APS. Additionally, serum PCDH18 levels in OAPS patients are significantly higher than in TAPS patients, suggesting that PCDH18 can serve as a biomarker for differentiating or assisting in the differentiation of TAPS and OAPS.

Disclosed are systems, devices and methods for laser microporation for rejuvenation of tissue of the eye, for example, regarding aging of connective tissue and rejuvenation of connective tissue by scleral rejuvenation. The systems, devices and methods disclosed herein restore physiological functions of the eye including restoring physiological accommodation or physiological pseudo-accommodation through natural physiological and biomechanical phenomena associated with natural accommodation of the eye. In some embodiments, the laser system may be configured to treat ocular tissue off axis or in a region of the eye which is distinct from the visual axis or directed away from the pupil of the eye where the gaze of the eye is.

The invention relates to the technical field of medical image processing, and discloses a breast X-ray photography auxiliary diagnosis system based on feature image selective area fusion. Comprising an image acquisition module used for acquiring a mammary gland X-ray tomographic image; the feature recognition module is used for performing feature recognition and marking on breast cancer calcification points, radial structures and circular focus high-density shadows in the breast X-ray tomographic image by using a deep learning method; the selected area fusion module is used for carrying out image synthesis on the key selected area according to the feature recognition and marking result, obtaining a synthesized image, reducing the absolute number of the images and keeping the diagnosis accuracy and sensitivity; and the three-dimensional positioning module is used for performing three-dimensional coordinate positioning on the synthesized image, outputting a focus position, dynamically optimizing 3D occupation of a focus in the synthesized image according to the focus position, analyzing and deeply learning a surrounding blood vessel and connective tissue density shadow, and outputting auxiliary diagnosis information.

The utility model discloses a rotary cutting tool bit structure convenient to penetrate through the compact texture of a flat drastic ladle, which comprises a horizontally arranged double-layer pipe structure, the double-layer pipe structure comprises an outer pipe body and a rotary tool bit, the rotary tool bit is connected with a driving mechanism for driving the rotary tool bit to rotate and is communicated with a negative pressure liposuction machine, and the negative pressure liposuction machine is communicated with the outer pipe body. The end, penetrating into the skin, of the double-layer tube structure is a front end face which is an inclined face, a plurality of first through holes are formed in the position, close to the front end face, of the rotary tool bit in a staggered mode, and second through holes are correspondingly formed in the positions, corresponding to the first through holes, of the outer tube body. According to the utility model, the front end face penetrating into the skin is changed from a plane to an inclined plane, which is more beneficial to penetrating through compact fibrous connective tissues in a drastic bag, and the operation process is more time-saving and labor-saving. The multiple first through holes and the multiple second through holes are formed, so that subcutaneous tissue can be sucked from multiple different angles to be smashed by the rotary cutter head, the situation that the tissue is uneven due to only one inlet is avoided, the adsorption efficiency is high in the final operation process, and tissue treatment is smooth.

The invention discloses application of a biomarker in diagnosis of connective tissue disease related interstitial lung diseases. According to the present invention, it is found that the MFAP5 protein can be adopted as the CTD-ILD diagnosis marker, and can be used for preparing the CTD-ILD diagnosis kit; specifically, the MFAP5 protein not only can be used for diagnosing and distinguishing a CTD-ILD patient from a healthy person, but also can be used for diagnosing and distinguishing the CTD patient from the CTD patient. From the perspective that the MFAP5 protein can be used for diagnosing and distinguishing CTD-ILD patients and CTD patients, the MFAP5 protein can be used for early diagnosis of the CTD patients involving ILD, and the CTD patients can discover whether ILD is involving or not in time by irregularly measuring the MFAP5 protein.

This invention discloses a method for extracting sturgeon roe for caviar production. The method involves obtaining target sturgeon and determining the optimal processing time window for the target sturgeon; performing a first low-temperature pretreatment on the raw roe mass to lower its center temperature to a first target temperature range; performing rinsing and grading operations on the initially separated roe mixture to remove impurities and separating the roe into at least two grades based on particle size, obtaining roe of each grade to be cured; draining at least one grade of roe to be cured, followed by salting, and completing all steps from slaughter to salting within a second preset time period to obtain primary sturgeon roe for caviar production. This invention employs a low-temperature pretreatment combined with a suitable temperature-controlled roe-rolling process, which promotes the separation of roe from connective tissue and significantly reduces the risk of mechanical damage, thus helping to maintain the integrity of the roe particles.

The invention provides a compound for treating connective tissue diseases and a pharmaceutical composition thereof. Specifically, the invention provides application of a compound shown as a formula I or pharmaceutically acceptable salt thereof in preparation of a pharmaceutical composition for preventing or treating connective tissue diseases.