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2048 results about "Computer simulation" patented technology
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Computer simulation is the reproduction of the behavior of a system using a computer to simulate the outcomes of a mathematical model associated with said system. Since they allow to check the reliability of chosen mathematical models, computer simulations have become a useful tool for the mathematical modeling of many natural systems in physics (computational physics), astrophysics, climatology, chemistry, biology and manufacturing, as well as human systems in economics, psychology, social science, health care and engineering. Simulation of a system is represented as the running of the system's model. It can be used to explore and gain new insights into new technology and to estimate the performance of systems too complex for analytical solutions.
Xylo-LNA analogues
Based on the above and on the remarkable properties of the 2′-O,4′-C-methylene bridged LNA monomers it was decided to synthesise oligonucleotides comprising one or more 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer(s) as the first stereoisomer of LNA modified oligonucleotides. Modelling clearly indicated the xylo-LNA monomers to be locked in an N-type furanose conformation. Whereas the parent 2′-deoxy-β-D-xylofuranosyl nucleosides were shown to adopt mainly an N-type furanose conformation, the furanose ring of the 2′-deoxy-β-D-xylofuranosyl monomers present in xylo-DNA were shown by conformational analysis and computer modelling to prefer an S-type conformation thereby minimising steric repulsion between the nucleobase and the 3′-O-phopshate group (Seela, F.; Wömer, Rosemeyer, H. Helv. Chem. Acta 1994, 77, 883). As no report on the hybridisation properties and binding mode of xylo-configurated oligonucleotides in an RNA context was believed to exist, it was the aim to synthesise 2′-O,4′-C-methylene-β-D-xylofuranosyl nucleotide monomer and to study the thermal stability of oligonucleotides comprising this monomer. The results showed that fully modified or almost fully modified Xylo-LNA is useful for high-affinity targeting of complementary nucleic acids. When taking into consideration the inverted stereochemistry at C-3′ this is a surprising fact. It is likely that Xylo-LNA monomers, in a sequence context of Xylo-DNA monomers, should have an affinity-increasing effect.
Owner:QIAGEN GMBH
Operatively tuning implants for increased performance
ActiveUS20100076563A1Improve balanceGood postoperative biomechanic functionPhysical therapies and activitiesMechanical/radiation/invasive therapiesBiomechanicsPatient acceptance
A method for preoperatively characterizing an individual patient's biomechanic function in preparation of implanting a prosthesis is provided. The method includes subjecting a patient to various activities, recording relative positions of anatomy during said various activities, measuring force environments responsive to said patient's anatomy and affected area during said various activities, characterizing the patient's biomechanic function from said relative positions and corresponding force environments, inputting the measured force environments, relative positions of knee anatomy, and patient's biomechanic function characterization into one or more computer simulation models, inputting a computer model of the prosthesis into said one or more computer simulation models, and manipulating the placement of the prosthesis in the computer simulation using said patient's biomechanic function characterization and said computer model of the prosthesis to approximate a preferred biomechanical fit of the prosthesis.
Owner:SMITH & NEPHEW INC
Methods for making character strings, polynucleotides and polypeptides having desired characteristics
InactiveUS7024312B1Simplifies overall synthesis strategyLow levelPeptide/protein ingredientsBiostatisticsPolynucleotideIn silico
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Owner:CODEXIS MAYFLOWER HLDG LLC
Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Owner:CODEXIS MAYFLOWER HLDG LLC
Computer-based training methods for surgical procedures
ActiveUS7427200B2Without expenseMaterial analysis using wave/particle radiationRadiation/particle handlingSystems analysisTechnical success
A method is disclosed for analyzing surgical techniques using a computer system for gathering and analyzing surgical data acquired during a surgical procedure on a body portion and comparing that data to pre-selected target values for the particular surgical procedure. The inventive method allows the surgeon, for example, to measure the technical success of a surgical procedure in terms of quantifiable geometric, spatial, kinematic or kinetic parameters. The method comprises calculation of these parameters from data collected during a surgical procedure and then comparing these results with values of the same parameters derived from target values defined by the surgeon, surgical convention, or computer simulation of the same procedure prior to the operation itself.
Owner:NOBLE PHILIP C +1
Identifying oligonucleotides for in vitro recombination
Owner:CODEXIS INC
Physically realistic computer simulation of medical procedures
InactiveUS7215326B2Improve reliabilityReduce fatigueProgramme controlMedical simulationElectricityThree degrees of freedom
An apparatus for interfacing the movement of a shaft with a computer includes a support, a gimbal mechanism having two degrees of freedom, and three electromechanical transducers. When a shaft is engaged with the gimbal mechanism, it can move with three degrees of freedom in a spherical coordinate space, where each degree of freedom is sensed by one of the three transducers. A fourth transducer can be used to sense rotation of the shaft around an axis. The method includes the steps of defining an origin in 3-dimensional space, physically constraining a shaft in the 3-dimensional space such that a portion of the shaft always intersects the origin and such that a portion of the shaft extending beyond the origin defines a radius in a spherical coordinate system, transducing a first electrical signal related to a first angular coordinate of the radius with a first transducer, transducing a second electrical signal related to a second angular coordinate with a second transducer, transducing a third electrical signal related to the length of the radius with a third transducer, and coupling the transducers to a computer.
Owner:IMMERSION CORPORATION
System and method for generating a patient-specific digital image-based model of an anatomical structure
Embodiments of the invention are directed to a method of performing computerized simulations of image-guided procedures. The method may comprise receiving medical image data and metadata of a specific patient. A patient-specific digital image-based model of an anatomical structure may be generated based on the medical image data and the metadata. A computerized simulation of an image-guided procedure may be performed using the digital image-based model and the metadata.
Owner:SIMBIONIX
Computer-simulated virtual reality environments for evaluation of neurobehavioral performance
InactiveUS20050216243A1Increase and decrease difficultyStrong specificityMedical simulationTelemedicineTest performanceNervous system
A virtual reality (VR)-based test battery wherein various neurobehavioral performance skills, including motor skills, sensory-perceptual skills, attention, and decision-making can be measured in human subjects. The invention can be used as a screening method within a virtual environment to provide an overall measure of general brain function relating to behavioral ability. In addition, the invention provides comprehensive VR-based neurobehavioral examinations tailored to individual subjects which can automatically self-adjust during operation in accordance with the specific purpose of the assessment, or for forms of cognitive or physical rehabilitation. According to the invention, patients with neurological and psychiatric dysfunctions can be assessed with physiologic monitoring as well as with anatomical and functional neuroimaging to non-invasively map the functional neuroanatomic correlates of VR-based test performance. In a preferred embodiment, the VR-based neurobehavioral testing system is portable allowing computerized tests to be administered in a desk-top or lap-top configuration, or via the Internet for tele-assessment of human subjects who are physically inaccessible to the test administrator. In a particularly preferred embodiment, the method of the invention is used for vocational assessment and training, wherein individual test scores are combined into a final metric useful for assessing a candidate's qualifications for employment, or certification in a particular skill.
Owner:GRAHAM SIMON +3
Method for virtual endoscopic visualization of the colon by shape-scale signatures, centerlining, and computerized detection of masses
InactiveUS20050152588A1Enhancing endoscopic visualizationEasy detectionImage enhancementImage analysisPattern recognitionData set
A visualization method and system for virtual endoscopic examination of CT colonographic data by use of shape-scale analysis. The method provides each colonic structure of interest with a unique color, thereby facilitating rapid diagnosis of the colon. Two shape features, called the local shape index and curvedness, are used for defining the shape-scale spectrum. The shape index and curvedness values within CT colonographic data are mapped to the shape-scale spectrum in which specific types of colonic structures are represented by unique characteristic signatures in the spectrum. The characteristic signatures of specific types of lesions can be determined by use of computer-simulated lesions or by use of clinical data sets subjected to a computerized detection scheme. The signatures are used for defining a 2-D color map by assignment of a unique color to each signature region.
Owner:UNIVERSITY OF CHICAGO
Computer assisted and/or implemented process and architecture for simulating, determining and/or ranking and/or indexing effective corporate governance using complexity theory and agency-based modeling
InactiveUS6154731AEffective corporate governanceMaximize short-term market gainFinanceResourcesQuantum complexity theoryComputer-aided
A computer program product stores computer instructions therein for instructing a computer to perform a process. The program product includes a recording medium readable by the computer, and computer instructions stored thereon instructing the computer to perform the process. The instructions and the process include determining and storing at least one enterprise attribute data, customer attribute data, shareholder attribute data and government attribute data, and implementing an enterprise computer simulation model that utilizes the attribute data and generates enterprise performance data. The enterprise simulation model evaluates the enterprise performance data with respect to the at least one of each other and predetermined criteria. The data from evaluated enterprise performance is then used for ranking, indexing, decision making, enterprise controlling and / or investment purposes, manually and / or electronically.
Owner:MONKS ROBERT +1
Video game characters having evolving traits
A server-based video game system maintains a number of video game characters having computer-simulated genetic (“digenetic”) structures that prescribe a number of physical and cognitive performance traits and characteristics for the video game characters. The system allows end users to establish remote online access to the game characters (via, e.g., the Internet). The results of competitions and training activities are based upon the game characters' digenetics, the conditions of the game environment, and the game characters' current levels of physical and cognitive development. The game characters' performance capabilities and cognition are updated continuously in response to the results of competitions and training activities. Competition and training results can be processed by the game servers and transmitted to the end user presentation devices for graphics rendering. In this manner, the video game system need not be burdened by network latency and other delays. The game system also supports game character breeding; game character evolution based upon the digenetics; and game character buying, trading, selling, and collecting.
Owner:DIGENETICS
Sna-based anomaly detection
ActiveUS20080109730A1Enhance intrusion detectionEasy to detectMemory loss protectionError detection/correctionAnomaly detectionEngineering
A method, system, and computer program product for enabling dynamic detection of anomalies occurring within an input graph representing a social network. More specifically, the invention provides an automated computer simulation technique that implements the combination of Social Network Analysis (SNA) and statistical pattern classification for detecting abnormal social patterns or events through the expanded use of SNA Metrics. The simulation technique further updates the result sets generated, based on observed occurrences, to dynamically determine what constitutes abnormal behavior, within the overall context of observed patterns of behavior.
Owner:NORTHROP GRUMMAN SYST CORP
Method and apparatus for providing an interface mechanism for a computer simulation
InactiveUS7249951B2Highly realistic feedbackHighly realistic motionManual control with multiple controlled membersDiagnosticsHigh bandwidthComputerized system
Owner:IMMERSION CORPORATION
Construction project management system and method
InactiveUS20050171790A1ResourcesSpecial data processing applicationsGraphicsGraphical user interface
A construction project management system generates a computerized simulation model of a construction project based on data accessed in project databases. The system maps engineering data into constructible elements in the computerized simulation model based on manufacturing data and organizes the constructible elements by construction crafts, construction areas, and systems for testing and turnover. Additionally, the system matches the constructible elements with one or more work steps based on project controls data and generates a visual display of the construction project. A user selects construction areas in the visual display of the construction project and selects constructible elements within the construction areas, via a graphical user interface of the system, to create work packages for work crews. Each work package comprises work steps for the constructible elements in the work package, and can include an estimated time and cost for executing the work steps in the work package.
Owner:BENTLEY SYST INC
In vivo simulator for microwave treatment
InactiveUS6175768B1Reduce the possibilityWide bandwidthElectrotherapyLavatory sanitoryPeristaltic pumpVentricular tachycardia
Owner:NASA
Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
Owner:CODEXIS MAYFLOWER HLDG LLC
Computer Simulation Method With User-Defined Transportation And Layout
A multi-user process receives input from multiple remote clients to manipulate avatars through a virtual environment modeled in a host memory. The environment includes portal objects operable to transport avatars, which are modeled objects operated in response to client input, between defined areas of the virtual environment. The portals are customizable in response to client input to transport avatars to destinations preferred by users. Adjacent defined areas are not confined in extent by shared boundaries. The host provides model data for display of the modeled environment to participating clients.
Owner:PFAQUTRUMA RES LLC
Model Predicting Fracturing of Shale
ActiveUS20130238304A1Promote recoveryMinimizes probabilityGeomodellingDesign optimisation/simulationWell loggingHydraulic fracturing
A model for predicting fracturing in shale can minimize surface disruption, protect groundwater, maximize efficiency of hydraulic fracturing, and manage fluids used in unconventional gas development. The model provides a more comprehensive understanding of the geological, geophysical, and geomechanical properties of shales and imbeds these properties in geomechanical computer simulations to predict both the reservoir performance from the fracturing, and the associated microseismic events generated by fracturing. Since the geological and geophysical properties can be estimated from surface seismic, well logs, and geologic concepts with regional context; the performance of the fracturing can be predicted and optimized. Since the microseismic events can be predicted with the model, the simulations can be verified and the model can be updated to be consistent with the observed microseismic.
Owner:ION GEOPHYSICAL CORP
Solving the distal reward problem through linkage of stdp and dopamine signaling
InactiveUS20080162391A1Smooth connectionDigital computer detailsArtificial lifeNerve networkCritical period
In Pavlovian and instrumental conditioning, rewards typically come seconds after reward-triggering actions, creating an explanatory conundrum known as the distal reward problem or the credit assignment problem. How does the brain know what firing patterns of what neurons are responsible for the reward if (1) the firing patterns are no longer there when the reward arrives and (2) most neurons and synapses are active during the waiting period to the reward? A model network and computer simulation of cortical spiking neurons with spike-timing-dependent plasticity (STDP) modulated by dopamine (DA) is disclosed to answer this question. STDP is triggered by nearly-coincident firing patterns of a presynaptic neuron and a postsynaptic neuron on a millisecond time scale, with slow kinetics of subsequent synaptic plasticity being sensitive to changes in the extracellular dopamine DA concentration during the critical period of a few seconds after the nearly-coincident firing patterns. Random neuronal firings during the waiting period leading to the reward do not affect STDP, and hence make the neural network insensitive to this ongoing random firing activity. The importance of precise firing patterns in brain dynamics and the use of a global diffusive reinforcement signal in the form of extracellular dopamine DA can selectively influence the right synapses at the right time.
Owner:NEUROSCI RES FOUND
Endothelium preserving microwave treatment for atherosclerosis
Method and apparatus are provided to treat atherosclerosis wherein the artery is partially closed by dilating the artery while preserving the vital and sensitive endothelial layer thereof. Microwave energy having a frequency from 3 GHz to 300 GHz is propagated into the arterial wall to produce a desired temperature profile therein at tissue depths sufficient for thermally necrosing connective tissue and softening fatty and waxy plaque while limiting heating of surrounding tissues including the endothelial layer and / or other healthy tissue, organs, and blood. The heating period for raising the temperature a potentially desired amount, about 20° C. within the atherosclerotic lesion may be less than about one second. In one embodiment of the invention, a radically beveled waveguide antenna is used to deliver microwave energy at frequencies from 25 GHz or 30 GHz to about 300 GHz and is focused towards a particular radial sector of the artery. Because the atherosclerotic lesions are often asymmetrically disposed directable or focussed heating preserves healthy sectors of the artery and applies energy to the asymmetrically positioned lesion faster than a non-directed beam. A computer simulation predicts isothermic temperature profiles for the given conditions and may be used in selecting power, pulse duration, beam width, and frequency of operation to maximize energy deposition and control heat rise within the atherosclerotic lesion without harming healthy tissues or the sensitive endothelium cells.
Owner:NASA
Cultural simulation model for modeling of agent behavioral expression and simulation data visualization methods
ActiveUS7263474B2Accurately indicatedDrawing from basic elementsSpeech analysisData sourceVisual tool
Owner:SEASEER R&D
Aging and elimination of avatars and associated objects from computer simulated displayed virtual universes
Aging of avatars and objects toward eventual removal or removal from the displayed virtual universe through enabling the setting of defined parameters for the aging of said avatars and objects toward eventual removal of said avatars and objects from said virtual universe space; and predetermining a set of events, the occurrence of any one of which events would modify the aging of selected avatars and objects.
Owner:ACTIVISION PUBLISHING
Method and apparatus for predicting the failure of a component
ActiveUS7016825B1Plug gaugesComputation using non-contact making devicesProbit modelComputer science
The invention provides a method and apparatus for predicting the failure of a component using a probabilistic model of a material's microstructural-based response to fatigue. The method predicts the component failure by a computer simulation of multiple incarnations of real material behavior, or virtual prototyping. The virtual prototyping simulates the effects of characteristics that include grain size, grain orientation, micro-applied stress and micro-yield strength that are difficult to simulate with real specimens. The invention provides an apparatus for predicting the response of a component to fatigue using the method.
Owner:VEXTEC CORP
Lithographic apparatus and method for optimizing an illumination source using photolithographic simulations
InactiveUS7030966B2Improve lighting conditionsConvenient ArrangementAnalogue computers for electric apparatusSemiconductor/solid-state device manufacturingPupilProjection system
A method for optimizing the illumination conditions of a lithographic apparatus by computer simulation, the lithographic apparatus including an illuminator and a projection system, includes defining a lithographic pattern to be printed on the substrate, selecting a simulation model, selecting a grid of source points in a pupil plane of the illuminator, calculating separate responses for individual source points, each of the responses representing a result of a single or series of simulations using the simulation model, and adjusting an illumination arrangement based on analysis of accumulated results of the separate calculations.
Owner:ASML NETHERLANDS BV
Dynamic SNA-based anomaly detection using unsupervised learning
ActiveUS7739211B2Easy to detectMemory loss protectionError detection/correctionAnomaly detectionBehaviour pattern
A method, system, and computer program product for enabling dynamic detection of anomalies occurring within an input graph representing a social network. More specifically, the invention provides an automated computer simulation technique that implements the combination of Social Network Analysis (SNA) and statistical pattern classification for detecting abnormal social patterns or events through the expanded use of SNA Metrics. The simulation technique further updates the result sets generated, based on observed occurrences, to dynamically determine what constitutes abnormal behavior, within the overall context of observed patterns of behavior.
Owner:NORTHROP GRUMMAN SYST CORP
Method and apparatus for a computer simulated environment
InactiveUS8239775B2Image data processingInput/output processes for data processingComputer graphics (images)Virtual world
This invention relates to a computer simulated environment, such as a virtual world, and to the identification of a user entering the virtual world and user context in the virtual world model. An output of the virtual world model may be rendered using objects in the virtual world model. Previous versions of the rendered objects may then be located in associated user memory and specified differences between the rendered objects and the previous versions of the objects may be identified. A layer of the identified differences may then be rendered on the rendered output of the virtual world model.
Owner:ACTIVISION PUBLISHING
Virtual blasting system for removal of coating and/or rust from a virtual surface
InactiveUS7817162B2High simulationImprove realismCathode-ray tube indicatorsEducational modelsAbrasive blastingElectronic controller
A computer simulation and virtual reality system simulates the use of a blasting nozzle to remove one or more coatings and / or rust from a virtual surface. The user operates an electronic controller in the form of a blasting nozzle that outputs a signal indicating whether the blasting nozzle controller is in an “on” position or in an “off” position. The system also has a motion tracking system that tracks the position and orientation of the blasting nozzle controller with respect to the virtual surface defined on the display screen. Simulation software in a computer generates virtual blast pattern data, and the removal of the virtual coating(s) and / or rust image from the virtual surface is displayed in real time on the display screen.
Owner:UNIV OF NORTHERN IOWA RES FOUND
Method For Multi-Scale Geomechanical Model Analysis By Computer Simulation
A method of predicting earth stresses in response to changes in a hydrocarbon-bearing reservoir within a geomechanical system includes establishing physical boundaries for the geomechanical system, acquiring logging data from wells drilled, and acquiring seismic data for one or more rock layers. The well and seismic data are automatically converted into a three-dimensional digital representation of one or more rock layers within the geomechanical system, thereby creating data points defining a three-dimensional geological structure. The method also includes (a) applying the data points from the geological structure to derive a finite element-based geomechanical model, and (b) initializing a geostatic condition in the geomechanical model, and then running a geomechanics simulation in order to determine changes in earth stresses associated with changes in pore pressure or other reservoir characteristics within the one or more rock layers.
Owner:EXXONMOBIL UPSTREAM RES CO
Method For Predicting Well Reliability By Computer Simulation
Methods of predicting earth stresses in response to pore pressure changes in a hydrocarbon-bearing reservoir within a geomechanical system, include establishing physical boundaries for the geomechanical system and acquiring reservoir characteristics. Geomechanical simulations simulate the effects of changes in reservoir characteristics on stress in rock formations within the physical boundaries to determine the rock formation strength at selected nodes in the reservoir. The strength of the rock formations at the nodes is represented by an effective strain (εeff), which includes a compaction strain (εc) and out-of-plane shear strains (γ1-3, Y2-3) at a nodal point. The methods further include determining an effective strain criteria (εeffcr) from a history of well failures in the physical boundaries. The effective strain (εeffcr) at a selected nodal point is compared with the effective strain criteria (εeffcr) to determine if the effective strain (εeff) exceeds the effective strain criteria (εeffcr).
Owner:EXXONMOBIL UPSTREAM RES CO
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