253 results about "Blood flow" patented technology

This invention discloses a blood purification device and medical system. The blood purification device includes: a device housing; a blood purifier; a blood tubing assembly, the blood tubing assembly including a first blood tubing connecting a human blood vessel to the inlet of the blood purifier and a second blood tubing connecting the outlet of the blood purifier to the human blood vessel; a power assembly including a blood pump for driving blood flow within the blood tubing assembly, a first replenishment pump for allowing anticoagulant solution to flow into the first blood tubing, and / or a second replenishment pump for allowing calcium solution to flow into the second blood tubing; and a blood component analysis component disposed within the device housing, the blood component analysis component being used to detect collected blood samples. This design facilitates the appropriate adjustment of anticoagulant drugs and calcium ions in the blood purification circuit.

The application discloses a breast-conserving surgery perforator flap intelligent navigation system and method based on CT three-dimensional blood vessel reconstruction and AI dynamic blood flow analysis, and comprises an image processing module. The image processing module generates a perforator blood vessel three-dimensional model with an accuracy of plus or minus 0.1 mm based on high-resolution CT thin-layer scanning data with a layer thickness of less than or equal to 0.625 mm through Mimics software. The application significantly improves the postoperative outcome of patients through multidimensional technology cooperation. In terms of complication control, the incidence of complications in the donor area is reduced from 22% in the traditional method to 3% (a reduction of 86%), and the expansion of trauma caused by perforator variation is avoided. In terms of aesthetic effect, for the breast-conserving surgery of medial quadrant breast cancer, the lateral thoracic artery perforator flap (LTAP) is combined with AI volume compensation. After the surgery, the postoperative breast upper pole depression rate is reduced from 35% to 5%, the BREAST-Q score of the patient is increased from 68 to 89, the requirements of 'tumor radical treatment' and 'functional aesthetics' are fully considered, the postoperative life quality of the patient is greatly improved, and the humanistic concept of modern tumor treatment is met.

The application discloses an aneurysm segmentation landing zone positioning and identifying method and system based on an optimal blood flow guiding model, and the method comprises the following steps: collecting image data of a target blood vessel region, and pre-processing the image data to obtain a blood vessel enhanced image; performing binaryzation on the blood vessel enhanced image to obtain a blood vessel cavity binary mask; extracting a tree-shaped blood vessel center line from the blood vessel enhanced image by using a blood vessel center line extraction algorithm; analyzing the tree-shaped blood vessel center line to obtain a multi-modal fusion feature vector; predicting a neck aneurysm probability value of the multi-modal fusion feature vector by using a pre-constructed neck aneurysm detection deep learning model, and screening a candidate neck aneurysm region and a parent artery region; and performing membrane membrane on the candidate neck aneurysm region and the parent artery region by using a blood vessel cavity three-dimensional binary mask, and extracting a device anchoring landing zone. According to the scheme, the neck aneurysm precisely positioned by the membrane membrane is taken as a starting point, and an anchoring landing zone section can be accurately screened out by searching upstream and downstream along the parent artery center line.

Provided herein are dry powder formulations comprising epinephrine alone or in combination with at least one enabling agent suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including anaphylaxis, anaphylactoid reaction, respiratory conditions, hemodynamic collapse, and for administration during cardiopulmonary arrest and other life-threatening conditions.

The utility model relates to a kind of partial plugging first-aid balloon, including catheter and balloon assembly, balloon assembly includes multiple balloon petals distributed along the circumference of catheter;Balloon petal includes first bag part when initial folding and sticking state, and second bag part located outside first bag part, first bag part includes first bag outer layer membrane, second bag part includes second bag outer layer membrane, second bag inner layer membrane located inside second bag outer layer membrane, the side edge of B side of first bag outer layer membrane is fixedly connected with catheter outer wall, the side edge of A side is connected with the side edge of A side of second bag inner layer membrane, the side edge of B side of second bag inner layer membrane is connected with the side edge of B side of second bag outer layer membrane, the side edge of A side of second bag outer layer membrane is fixed with catheter outer wall;Adjacent two balloon petals form blood passage for blood flow between when balloon petal is inflated after filling fluid medium and is in inflation working condition;Catheter is equipped with filling cavity and filling port, and the inner cavity of each balloon petal is respectively communicated with at least one filling port.

The application discloses a blood purification device and a storage medium. The device comprises a memory and a processor. The memory stores a computer program, and the processor executes the computer program to realize the method. When the actual rotating speed of a first peristaltic pump detected is greater than a preset rotating speed, the pressure alarm range of an arterial pipeline and the pressure sampling period of a first pressure sensor are determined according to the actual rotating speed of the first peristaltic pump. The first pressure sensor is controlled to periodically sample the blood pressure of the arterial pipeline according to the pressure sampling period, and a plurality of continuous first detection pressures are obtained. Whether the first peristaltic pump is stopped is determined according to the first average pressure of the plurality of continuous first detection pressures and the pressure alarm range of the arterial pipeline. In this way, the application can more accurately and timely discover the pressure fault of the arterial pipeline, and improve the blood flow safety of the arterial pipeline.

This invention discloses an intelligent psychological guidance system for harmonizing the Qi of the internal organs based on TCM emotional differentiation, belonging to the field of medical electronic equipment. The system includes a multi-node physiological signal acquisition module, a central control and data processing module, and an acoustic intervention output module. The system synchronously acquires multi-channel bioimpedance, volumetric pulse wave, and electrocardiogram signals, extracts pulse wave conduction time and local blood perfusion index, constructs Qi characteristic parameters, and maps them to generate emotional tags. The central control module locks the target resonance unlocking frequency according to the tags, modulates low-frequency vibrations with reference audio to synthesize a multimodal signal, and further combines physiological pulse transmission delay to perform phase compensation, controlling the precise output of the intervention signal during ventricular diastole. Steady-state determination and closed-loop tracking are performed based on the dynamic gradient of impedance variance. This invention achieves objective quantification of TCM differentiation and ensures high-precision physical alignment between intervention energy and the hemodynamic state of the internal organs.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

A cuff is provided for use in measuring hemodynamic parameters, the cuff having a shell portion for surrounding a body portion of a subject and pressure applying means surrounding the shell portion, the shell portion being positioned between the actuator and the body portion. The shell portion is formed to have at least two circumferential portions that form a closed loop around the body portion of the subject when the cuff is assembled on the body portion of the subject. For example, the shell portions overlap at their respective ends, forming at least a first overlapping region and a second overlapping region. By forming a shell structure with multiple circumferential portions, it is possible to open the shell portion from the side by sliding it to separate the shell portion at at least one tangential confluence point between the circumferential portions. For example, in some embodiments, the shell structure can be opened by sliding it tangentially to separate at least two shell portions in the first overlapping region.

Implantable medical devices and methods that utilize a sensing circuit to sense cardiac activity (CA) signals and an accelerometer to obtain accelerometer data. Memory stores program instructions and device parameters associated with a collection of ventricular arrhythmia (VA) therapies. A processor analyzes the CA signals over one or more cardiac beats, determines a VA episode based on the analysis of the CA signals, determines the VA episode to be hemodynamically stable or unstable based on at least one of the accelerometer data or the CA signals, selects a first VA therapy from the collection of VA therapies based on whether the VA episode is hemodynamically stable or unstable, and apply the first VA therapy using at least one of the at least two coils.

Methods, apparatus, and systems are provided to control contraction of the heart. At least one sensing element receives signals indicating electrical activity of sinus rhythm of the heart. Based on the received signals, the progress of contraction of the heart is determined. Based on the progress of contraction, the chamber of the heart may then be stimulated at a plurality of locations. In another embodiment, a plurality of electrodes are implanted in the left ventricle to stimulate at multiple locations in the left ventricle for the purpose of improving hemodynamic performance and increasing cardiac output in a patient who is suffering from congestive heart failure.

The application discloses a physical cooling device for lower limbs in emergency treatment, which comprises a rack, a driving assembly, a motion assembly, a limb bracket and a linkage assembly. The crank disc of the motion assembly is connected with the driving shaft. The connecting rod and the rocker are driven by the pin shaft with adjustable crank radius, so that the limb bracket installed at the free end of the rocker reciprocates and drives the lower limbs of the patient to make passive movement. The protrusion of the linkage assembly is fixed on the crank disc and intermittently opens the micro switch to control the alcohol spray of the alcohol atomization source to be sprayed from the nozzle installed on the limb bracket, and the spraying direction is directed to the popliteal fossa position. The lower legs of the patient are driven by the motion assembly to make periodic reciprocating swing, the muscle pump effect is utilized to promote the venous return and local blood circulation of the limbs, the blood flow of the large blood vessel area at the popliteal fossa is accelerated, and the intermittent alcohol mist spraying of the linkage assembly is matched, so that the heat exchange efficiency between the blood and the cold medium is improved.

This invention relates to the field of medical testing equipment, specifically to a pulsatile tinnitus detection device. The device includes a wearable body worn on the user's head, with symmetrically arranged sensing mechanisms on the wearable body for contacting specific areas of the user's skull to collect physiological signals. The wearable body also includes an intervention mechanism for simulating different hemodynamic states; the intervention mechanism includes an actuator and a compression head, the actuator driving the compression head to perform controllable compression and release. A control unit is also included, communicatively connected to the sensing and intervention mechanisms. The control unit controls the actions of the intervention mechanism, receives and analyzes the physiological signals collected by the sensing mechanisms, and correlates changes in physiological signals with the timing of compression and release actions to generate assessment information for determining the cause of pulsatile tinnitus, intraoperative effects, or postoperative recovery. This invention is used to objectively assess vascular recovery status, providing standardized and comparable assessment indicators for diagnosis and treatment.

This invention belongs to the field of biomedical technology, specifically relating to a madder-derived exosome-like nanovesicle, an artificial blood vessel, and their preparation and application. This invention utilizes differential centrifugation and sucrose density gradient centrifugation techniques to extract high-purity, highly active exosome-like nanovesicles from madder. Then, polydopamine is loaded onto the surface of a small-diameter polyurethane artificial blood vessel, which is then immersed in a suspension of madder-derived exosome-like nanovesicles to obtain a small-diameter artificial blood vessel loaded with madder-derived exosome-like nanovesicles. These madder-derived exosome-like nanovesicles can effectively promote endothelial cell proliferation and inhibit reactive oxygen species generation; animal experiments show unobstructed blood flow under ultrasound. The small-diameter artificial blood vessel loaded with madder-derived exosome-like nanovesicles can simultaneously achieve in vivo endothelialization and vascular patency, possessing significant clinical application value.

Methods and apparatus disclosed herein relate to graphical representation of patient hemodynamic state. In various embodiments, one or more measured physiological parameters of a patient may be analyzed. Based on the analysis, a graphical user interface (GUI) may be rendered. The GUI may include a figure-eight schematic (222, 1222) that represents a circulatory system of the patient. The figure-eight schematic may include: a first loop (224, 1224) that represents pulmonary circulation of the patient; a second loop (226, 1226) that represents systemic circulation of the patient; and a central object (228, 1228) that connects the first and second loops represents a heart of the patient. In various embodiments, each of the first and second loops includes multiple arc fragments, with each arc fragment being shaped to convey one or more of the measured physiological parameters of the patient.

The application provides a highland thrombosis disease risk early warning system, comprising: a sensing acquisition module, which is used for acquiring patient characteristic data, the patient characteristic data including physical sign data and individual baseline data; an index analysis module, which is used for preprocessing the patient characteristic data and generating risk indexes; a risk assessment module, which is used for assessing a risk coefficient according to the risk indexes; and a risk early warning module, which is used for obtaining a risk degree corresponding to the risk coefficient according to a pre-constructed risk classification standard, and implementing corresponding risk early warning according to the risk degree. The application solves the problem in the prior art that a portable health monitoring device cannot accurately measure core hemodynamic parameters closely related to thrombosis, and also cannot accurately perform risk early warning on highland thrombosis diseases according to the acquired parameters.

An extracorporeal membrane oxygenation (ECMO) system including a blood oxygenator having an outer shell surrounding an oxygenator fiber bundle, a heating element, a closed loop control system, and a temperature sensor. The blood oxygenator defining a blood inlet and a blood outlet. The blood oxygenator has a blood flow path that is bifurcated between a first channel and a second channel. The heating element disposed around or within the outer shell. The closed loop control system configured to regulate the heating element. The temperature sensor is electronically linked to the control system. The heating element extends alongside at least one of the first channel and the second channel.

This invention provides a deep learning-based intelligent analysis method for cardiovascular medical images, comprising the following steps: S1, heterogeneous data fusion and acquisition of multimodal medical images and physiological signals; S2, intelligent extraction and quantitative analysis of vascular structural features based on deep learning; S3, hemodynamic parameter modeling and risk region segmentation based on fused structural features; S4, texture feature mining and intelligent identification of lesion types in high-risk areas; S5, cardiovascular disease risk stratification prediction based on multi-dimensional feature fusion; S6, federated learning optimization and closed-loop update of the model. This invention's deep learning-based intelligent analysis method for cardiovascular medical images achieves, for the first time, heterogeneous fusion of medical images, millimeter-wave radar-PPG physiological signals, and clinical molecular data, and achieves precise spatiotemporal alignment through GPS-controlled crystal oscillators, overcoming the limitations of single image analysis and providing a more comprehensive feature foundation for subsequent feature extraction and risk prediction.

A system for monitoring arterial pressure of a patient determines a score that is predictive of responsiveness of the patient to a therapy. Sensed hemodynamic data representative of an arterial pressure waveform of the patient are received by a hemodynamic monitor. Magnitude data and trend data are derived from the hemodynamic data. The score that is predictive of the responsiveness of the patient to the therapy is determined based on the magnitude data and the trend data of the hemodynamic parameter. A representation of the score is output.

The application discloses a fetal congenital heart disease intervention path reasoning method and system based on atlas enhanced retrieval, and relates to the technical field of medical data processing and intelligent auxiliary decision-making.The application constructs a domain knowledge graph containing anatomical structure, hemodynamics and evolution law, and establishes a graph-text hybrid index; in the reasoning stage, a large language model is used to extract key features of the target fetus and its mother, multi-hop retrieval and subgraph matching are performed in the atlas, and knowledge context with medical logic constraints is obtained; finally, the thinking chain technology is combined to guide the large model to generate a hierarchical intervention path containing prenatal monitoring, perinatal management and postpartum surgery. The application solves the problem that the existing large model has hallucination and lacks time sequence reasoning ability in complex medical decision-making, and improves the accuracy and explainability of the intervention scheme.

A system for determining a global hypoperfusion index (GHI) includes an arterial blood pressure sensor, a ventricular blood pressure sensor, an oximetry module, and an integrated hardware unit including a system processor and a system memory. The system memory includes instructions that cause the system to receive arterial hemodynamic data, ventricular hemodynamic data, and blood oxygen saturation data. One or more right ventricular pressure features, one or more pulmonary artery pressure features, one or more cardiac output parameters, and one or more venous oxygen saturation parameters are derived from the arterial hemodynamic data, the ventricular hemodynamic data, and the blood oxygen saturation data. The GHI is derived by using a predictive decision model based upon the one or more right ventricular pressure features, the one or more pulmonary artery features, the one or more cardiac output parameters, and the one or more venous oxygen saturation parameters.

The present invention relates to an ophthalmic ultrasonic emulsification sleeve for confirming intraocular and extraocular penetration and perfusion, which allows determining whether aqueous humor communication between the inside and outside of the eye is smooth through a microtube implanted in the eye during glaucoma tube surgery. The sleeve is characterized by having a rigid branch tube made of a material harder than a sleeve made of a soft material, provided in a perfusion port that allows the injection of a balance salt solution into the eye, and with the branch tube connected to the perfusion port, the tip of the branch tube protrudes further than the tip of the Paco tip, and the end of the microtube inside the eye is connected to the tip of the branch tube, so that the establishment of aqueous humor communication of the microtube can be quickly and accurately and sensorially confirmed based on the pattern of pressure change in the conjunctival area and surrounding blood flow change that occurs when the balance salt solution leaks out of the eye.

A collar worn around the neck of an animal delivers non-invasive light energy to free-floating mitochondria flowing through the animal's veins and arteries. The collar comprises a housing which holds at least one light source, a power source, a controller and in some configurations a reflector. The housing has an aperture through which the light energy is emitted towards the animal's tissue. The housing is connected to a band or harness, which positions the housing where the neck broadens out to the shoulder. Preferably the collar is secured around the neck of the animal loosely enough that the housing falls naturally by gravity to where the neck broadens out to the shoulder. The non-invasive light energy impinges the animal's fur or tissue and penetrates to free- floating mitochondria in the blood flowing through the animal's veins and arteries. This results in improved oxidative phosphorylation and mitochondrial function in the treated mitochondria.

The application relates to the technical field of kidney dialysis medical equipment, in particular to a kidney dialysis blood multi-stage filtering device with optimized flow channels, which comprises a device body; three groups of filtering cylinders are driven in linkage by a micro motor, a rotating shaft, a driving gear and a transmission gear ring, the driving gear and the transmission gear ring are sequentially reduced from top to bottom, the three groups of filtering cylinders rotate at different rotating speeds, the internal filtering units are driven to work efficiently, the filtering unit apertures are sequentially reduced from top to bottom, the filtering unit apertures are respectively set as pretreatment filtering units, precision filtering units and deep adsorption filtering units, a grading purification system is formed, different molecular weight toxins can be targetedly removed, the linkage structure of a pawl, a ratchet ring, a connecting rotating rod and a return spring can dynamically adjust the angle of the filtering units according to the changes of blood flow and pollution degree, the occurrence risk of low proteinemia of patients can be effectively reduced, the device can be flexibly adapted to the disease differences of different patients, individualized precise treatment can be realized, and the kidney dialysis treatment effect is improved.

This application discloses a method and system for microvascular anastomosis modeling and effect prediction in assisted spermatic cord anastomosis, relating to the field of data processing technology. The method includes: extracting the pampiniform plexus topology and varicose vein segments from a three-dimensional vascular tree model of the spermatic veins constructed based on spermatic cord vessel images; determining candidate diversion inlet locations based on the spatial adjacency relationship between the obstructed reflux nodes identified by the varicose vein segments and the pampiniform plexus topology; spatially registering the contour of the inferior epigastric vein segmented from the superficial vein images of the inguinal region with the candidate diversion inlet locations to generate a diversion anastomosis path planning map; constructing the geometric configuration of the end-to-side anastomosis and performing hemodynamic simulation to generate a wall shear stress distribution field, assess the thrombosis tendency of the end-to-side anastomosis, and generate a postoperative patency rate prediction value. This application can predict the risk of thrombosis preoperatively through hemodynamic simulation, providing a reliable basis for surgical planning and effectively improving the success rate of the surgery.

The utility model provides a kind of sole blood sampling practice model, belong to the technical research field of teaching model. For the current existing sole blood sampling practice model cannot judge whether the needle position is accurate, and only through sole massage mode to simulate the blood flow of newborn, the utility model is increased two detachable local blood sampling pieces on sole model, each local blood sampling piece is separated by separating piece to separate its internal accommodating cavity into first hyperemia cavity and second hyperemia cavity;When using, the side of local blood sampling piece with first hyperemia cavity is located in sole side edge, the side of local blood sampling piece with second hyperemia cavity is located in foot side;Practitioner extrudes fluid in second hyperemia cavity into first hyperemia cavity to simulate sole hyperemia, and then learner only makes fluid in local blood sampling piece flow out when pricking needle in sole lateral margin or sole medial margin, if needle position is incorrect, there will be no fluid flow, high degree of authenticity, good teaching effect.

This invention relates to a pharmaceutical composition and its application for treating acute ischemic stroke. The pharmaceutical composition for treating acute ischemic stroke comprises separately packaged tissue-type plasminogen activator citPA5 and a platelet aggregation inhibitor. Its beneficial effects include significantly improving cerebral blood flow recovery, shortening thrombolysis time, reducing infarct volume, and improving neurological function without increasing the risk of bleeding, demonstrating a good synergistic thrombolytic effect.

This invention belongs to the field of biomedical technology and relates to the application of OSM inhibitors in the preparation of drugs for the prevention or treatment of calcific aortic valve disease. This invention reveals for the first time that OSM drives osteogenic differentiation and calcified nodule formation of valvular interstitial cells through the OSM-OSMR-JAK2 / JAK3-STAT3-RUNX2 signaling axis, which is the core pathogenic mechanism leading to calcific aortic valve disease. This invention utilizes anti-OSM neutralizing antibodies or sulforaphane to effectively block this signaling axis, significantly inhibiting macrophage infiltration, valvular calcification, and improving hemodynamic abnormalities. This invention provides a precise target and a novel strategy for the modification therapy of calcific aortic valve disease, solving the technical problem of the ineffectiveness of traditional broad-spectrum anti-inflammatory therapy in valvular calcification.