36 results about "Vascular body" patented technology

The invention discloses a standardized cerebrovascular feature extraction method and device and a medium, and relates to the field of cerebrovascular feature extraction, and the method comprises the steps: calculating the blood vessel length and the blood vessel volume based on a target cerebrovascular three-dimensional segmentation image, and determining a blood vessel center line based on Voronoi covariance measurement; according to the blood vessel center line, the blood vessel diameter, the blood vessel curvature radius, the blood vessel bending degree, the blood vessel bifurcation angle and the blood vessel bifurcation density are calculated; performing nonlinear registration on the target cerebrovascular three-dimensional segmented image and a preset standard brain template to obtain a plurality of target standard cerebrovascular partitions and individual feature results in each target standard cerebrovascular partition; and performing group level analysis on the target cerebrovascular three-dimensional segmented image based on a voxel morphological measurement method to obtain a group feature result. According to the invention, multi-level standardized, accurate and stable cerebrovascular feature extraction can be realized.

To provide drug-coated balloon catheters for treating, preventing or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen, and methods of using the same.SOLUTION: A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism, which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.SELECTED DRAWING: Figure 5A

A wraparound label (10) for a container (40) has a first label section (11) with a first perforation (14) and a second label section (12) with a second perforation (15). The label sections (11, 12) are coupled together and their perforations (14, 15) each comprise a plurality of perforation openings (141, 151) and an intervening perforation space (18).The first and second label sections (11, 12) are each designed to wrap around the circumference of a vessel body (41) and / or a vessel closure (42) of the vessel (40) at least once, so that, with reference to an operationally applied state of the over-label (10) on the vessel (40), the first and second label sections (11, 12) wrap around the vessel body (41) and / or the vessel closure (42) completely, and the perforation openings (141, 151) of the first and second perforation (14, 15) are offset from each other with respect to a winding or application direction (R, A) and are designed without overlap.

The invention discloses a three-dimensional reconstruction model training method and a blood vessel three-dimensional reconstruction method and device. The training method of the three-dimensional reconstruction model comprises the following steps: acquiring a plurality of two-dimensional blood vessel body drawing training images, wherein the plurality of two-dimensional blood vessel body drawing training images are acquired from different acquisition angles; inputting a plurality of two-dimensional blood vessel volume rendering training images into the neural network model to obtain a three-dimensional blood vessel voxel model; reducing the three-dimensional blood vessel voxel model into a plurality of two-dimensional rendering images based on projection matrixes corresponding to the obtained two-dimensional blood vessel body drawing training images through a differentiable rendering method; calculating a loss value based on the plurality of two-dimensional blood vessel body drawing training images and the plurality of two-dimensional rendering images, adjusting model parameters of the neural network model based on the loss value, and obtaining a three-dimensional reconstruction model when the loss value meets a set condition, the trained three-dimensional reconstruction model can simply and efficiently generate a three-dimensional model of a blood vessel based on a blood vessel image with a limited angle.

The invention relates to the technical field of medical care, in particular to a cardiovascular disease risk dynamic early warning system based on multi-source data fusion, and the system comprises the steps: obtaining ejection fraction, coronary artery stenosis percentage and calcification integral data of cardiovascular examination of a monitored object, and heart rate data and pulse pressure difference data of periodic signs; determining a physical examination abnormal coefficient according to the difference between the ejection fraction and the standard value and the difference between the calcification integral data and the standard value and the coronary artery stenosis percentage; according to the height and slope difference of the ST wave band and the PR wave band, the heart rate analysis abnormal index is determined by combining the time interval of the adjacent electric activity wave bands; according to the time sequence change correlation of the heart rate data and the pulse pressure difference data, a physical sign abnormal coefficient is determined; determining a dynamic risk score in combination with the physical examination abnormal coefficient and the physical sign abnormal coefficient; and carrying out risk early warning based on the dynamic risk score. According to the invention, fusion analysis of multi-source and multi-dimensional data can be realized, and the dynamic early warning precision of cardiovascular risks is improved.

An ultrasonic diagnostic imaging system measures volume flow. An ultrasound probe operating in biplane mode is used to acquire a blood vessel in a long axis view in a first Doppler image and simultaneously in a transverse view in a second Doppler image. Volume flow is calculated from the transverse view of the blood vessel. The plane of the second image is aligned with the Doppler angle of the first image so that angle correction determined for the first image can be used for angle correction in the volume flow calculation.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

The invention relates to the technical field of organs, and discloses a culture medium and a method for constructing and culturing vascular organs and application of the culture medium and the method. By utilizing the culture medium set provided by the invention, the vascular organoid with complete functions and structures can be constructed through iPSC induction, and matrigel does not need to be adopted in the construction and culture process, so that the construction operation of the organoid is greatly simplified, and the cost is saved. The blood vessel organoid constructed by the invention has a basic structure of a blood vessel, has corresponding response to medicine components which are known in the field and have influence on the blood vessel, and can be used as a blood vessel in-vitro model.

The application provides a chest plain CT image lung artery and vein automatic extraction method, and relates to the technical field of CT image processing. The method first acquires lung airway, lung blood vessel and lung external artery and vein data, and performs data preprocessing and unifies layer thickness; then, based on the reconstructed CT scan image, lung blood vessel skeletonization is performed; and a lung internal artery and vein growth algorithm is used to classify the lung blood vessel skeleton; then, the lung artery and vein are reconstructed according to the artery and vein marked by the lung blood vessel skeleton; finally, the classified lung blood vessel is evaluated according to the blood vessel skeleton of the marked lung internal artery and vein and the blood vessel voxel point after the lung internal artery and vein reconstruction. The method uses multiple features to classify the lung internal artery and vein, does not require the imaging mode of the input data, is an automatic algorithm, does not require manual parameter adjustment or seed point setting, has strong generalization ability, and proposes two new evaluation methods, so that the classification effect of the lung artery and vein is checked and evaluated from multiple angles.

The application belongs to the field of intelligent medical treatment, and particularly relates to a method for constructing a refractory mycoplasma pneumoniae pneumonia prediction model and equipment. The method comprises the following steps: acquiring a baseline time data set and a follow-up time label of a mycoplasma pneumoniae patient; inputting the image data set into a lung blood vessel segmentation model to obtain a lung blood vessel network, obtaining a total lung blood vessel volume based on the lung blood vessel network, and obtaining a blood vessel volume of different cross-sectional areas based on a cross-sectional area of the lung blood vessel network; inputting a ratio of the blood vessel volume of different cross-sectional areas to the total lung blood vessel volume into a machine learning model to obtain a prediction label, and obtaining a refractory mycoplasma pneumoniae pneumonia prediction model after iterative optimization of the machine learning model based on a difference between the prediction label and the follow-up time label. The application segments a lung CT image to obtain a blood vessel network diagram, quantitatively obtains a percentage of a blood vessel volume of different thicknesses in a total lung blood vessel volume, and constructs a refractory mycoplasma pneumoniae pneumonia prediction model based on an innovative feature extraction method.

The invention relates to medical device (1) to be inserted in a defect blood vessel, body cavity, or body duct for treatment or pretreatment thereof. The medical device (1) comprises a hollow shaft (2) having the ability to slidably house an injection means (3), the hollow shaft (2) having a distal end (4) and a proximal end (5), and an elongated holding device (6) connected to the hollow shaft (2), the elongated holding device (6) having a distal end (7) and a proximal end (8). The invention also relates to a kit for the treatment, preferably ablation treatment, of defective blood vessels, body cavities, or body ducts.

The invention discloses a lipid T-LCBI quantification method and system based on multi-modal space fusion, and the method comprises the steps: obtaining multi-modal blood vessel imaging data for registration, and achieving image distortion correction through cross-correlation correction; quantizing the boundary of the lipid plaque based on the fusion data, and obtaining quantized lipid plaque volume data based on continuous multi-frame fusion data; constructing blood vessel body data based on continuous multi-frame fusion data, fusing the blood vessel body data with coronary angiography data, and calculating a lipid plaque space correction coefficient of the curved blood vessel segment based on blood vessel space trend information; calculating a lipid volume based on the quantized lipid plaque data and a spatial correction coefficient; and calculating the T-LCBI index according to the ratio of the lipid volume to the total volume. Through registration fusion and distortion correction of multi-modal imaging data, a lipid boundary quantification bottleneck is broken through, blood vessel body data and coronary angiography data are fused, complete space trend information is constructed, and the calculation accuracy of an LCBI index is improved.

The present application discloses a method, device and medium for extracting standardized cerebrovascular features, relating to the field of cerebrovascular feature extraction. The method includes: calculating the blood vessel length and blood vessel volume based on the three-dimensional segmentation image of the target cerebrovascular vessels, and determining the blood vessel centerline based on the Voronoi covariance metric; calculating the blood vessel diameter, blood vessel curvature radius, blood vessel bending degree, blood vessel bifurcation angle and blood vessel bifurcation density respectively according to the blood vessel centerline; performing non-linear registration on the three-dimensional segmentation image of the target cerebrovascular vessels and a preset standard brain template to obtain a plurality of target standard cerebrovascular partitions and the individual feature results within each target standard cerebrovascular partition; performing population-level analysis on the three-dimensional segmentation image of the target cerebrovascular vessels by means of voxel-based morphological measurement to obtain population feature results. The present application can achieve multi-level standardized, accurate and stable cerebrovascular feature extraction.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

The application discloses a method for motion interaction of liver parenchyma and intrahepatic blood vessels and blood in a virtual surgery scene, mainly comprising: generation of a visual liver body model and an intrahepatic blood vessel body model; generation of a liver parenchyma body model; generation of a dense mesh of the intrahepatic blood vessel body model by means of a gmsh software, and generation of an intra-blood vessel blood model composed of a blood flow particle set; establishment of a liver parenchyma motion model based on PBD, and motion trends of the liver parenchyma and the intrahepatic blood vessels under the action of an external force, which are used to represent the motion of the liver parenchyma under the action of the external force, and the motion of the blood vessels and the blood particles caused by the deformation of the liver parenchyma, and simultaneously contain the flow of the blood particles under the condition of cutting; and realization of the motion constraints between the intrahepatic blood vessels and the liver parenchyma, and the motion constraint conditions of the blood flow in the blood vessels under the action of the external force in the virtual surgery scene. The method fully considers the motion characteristics of the liver and the blood vessels under the action of the force.

Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

The invention belongs to the technical field of blood collection tubes, and particularly relates to an improved neonatal blood collection tube which comprises a storage barrel, a blood collection tube body is arranged in the storage barrel, a guide groove is formed in the storage barrel, a strip-shaped frame corresponding to the guide groove is fixedly installed on the blood collection tube body, and a connecting plate is fixedly installed at the bottom end of the blood collection tube body. A piston block is fixedly installed at the bottom of the connecting plate, a positioning assembly is fixedly installed at the bottom end of the storage barrel, a limiting assembly is arranged in the storage barrel, and a rubber plate is fixedly installed on the strip-shaped frame. According to the improved neonatal blood collection tube, the position of the improved neonatal blood collection tube is conveniently fixed and limited through the arranged negative pressure groove, the blood collection tube body is pulled to drive the piston block to move, the interior of the negative pressure groove is in a negative pressure state, the position of the improved neonatal blood collection tube can be limited, and fixing and using are convenient; the convenience of the improved neonatal blood collection tube in the use period is improved, the improved neonatal blood collection tube is not limited to a storage rack for supporting and fixing any more, and the flexibility is improved.

A radial displacement pulse wave measuring device and application methods thereof are provided. The radial displacement pulse wave measuring device includes an airbag, a pressure control module, a displacement sensing module, and a computing unit. The pressure sensor of the pressure control module is configured to measure a vascular volumetric pulse wave of an artery, while the displacement sensing module is configured to measure a vascular radial displacement pulse wave by detecting dynamic distance variations between the displacement sensing module and a measure site covering the artery. The computing unit controls pressure adjustment of the airbag via the pressure control module and scanning via the displacement sensing module to optimize measurement conditions for accurately recording the vascular radial displacement pulse wave.

The invention relates to the technical field of medicine, in particular to a multifunctional cuttlebone microneedle patch and a preparation method thereof. The multifunctional cuttlebone microneedle patch provided by the invention is composed of a needle body layer and a backing layer. The needle body layer is loaded with cuttlebone decalcified powder and silver nanoparticles; and the backing layer is made of chitosan hydrogel. The multifunctional cuttlebone microneedle patch provided by the invention has good biological activity, can continuously release silver ions (Ag < + >) and active ingredients, can remarkably inhibit related bacteria in vitro, prolong antibacterial aging and promote cell proliferation, migration and vascularization, and in-vivo results show that the patch can accelerate wound healing, promote collagen deposition and blood vessel maturation and relieve inflammation.

The invention provides a blood vessel three-dimensional reconstruction method and system based on digital subtraction angiography, and relates to the technical field of medical image processing and three-dimensional reconstruction. The method comprises the following steps: performing frame-by-frame registration, subtraction processing and uniform sampling on a collected two-dimensional digital subtraction angiography DSA image sequence to obtain a frame sparse view; constructing and training a vessel three-dimensional reconstruction network based on the sparse view angle dynamic DSA, inputting the frame sparse view into the trained vessel three-dimensional reconstruction network based on the sparse view angle dynamic DSA, and generating geometric parameters and center attenuation values of all Gaussian kernels; calculating three-dimensional blood vessel volumes under all timestamps and performing voxelization averaging on the three-dimensional blood vessel volumes under all timestamps on the basis of the geometric parameters and the center attenuation values of all Gaussian kernels, and generating a static three-dimensional blood vessel model; and meanwhile, all Gaussian kernels are rendered to generate a synthesized DSA image under a new view angle. The invention aims to improve the integrity and the time sequence consistency of the micro blood vessel reconstruction under the sparse view angle.

The invention relates to the technical field of acupoint positioning and computer image processing, and discloses an auxiliary acupoint positioning method based on image fusion, which comprises the following steps: receiving an acupoint selection instruction input by a user, and confirming a target acupoint; acquiring a target area subcutaneous blood vessel distribution image and a body surface image of the target acupuncture point; fusing the subcutaneous blood vessel distribution image and the body surface image to obtain a blood vessel-body surface fusion model of the target area; based on the blood vessel-body surface fusion model and a blood vessel distribution-acupuncture point model, calculating a target acupuncture point prediction coordinate; and converting the calculated target acupuncture point prediction coordinate into a laser projection instruction, controlling a laser emitter to project a positioning light spot to the body surface, and outputting acupuncture point information.

Various embodiments disclosed relate to drug-coated balloon catheters for treating, preventing, or reducing the recurrence of a stricture and / or cancer, or for treating benign prostatic hyperplasia (BPH), in a non-vascular body lumen and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent. In some embodiments, the balloon catheter includes a length-control mechanism which stretches and elongates the balloon when it is in a deflated state, giving the balloon a smaller cross-sectional deflated profile for tracking through the body lumen and for removal after treatment.

The present invention belongs to the field of biomedical engineering, and provides a vascular culture experimental cavity device that can be repeatedly sterilized at high temperature. By using a vascular connecting tube with adjustable length and a convenient vascular installation device, it provides an experimental cavity device for realizing in vitro simulated culture of blood vessels and can be used for experiments on simulating blood flow stimulation of blood vessels; the vascular assembly is realized through an external fixing device, which enables convenient assembly of blood vessels, is easy to implement, and reduces the risk of contamination during operation; at the same time, the method of pressing realizes the placement of blood vessels into the vascular culture cavity.

The invention relates to the technical field of medical apparatus and instruments, and discloses a vascular anastomosis device for vascular surgery, which comprises two groups of vascular connecting pieces arranged on a vascular main body in a sleeving manner, annular pieces are fixed to the outer ports, close to each other, of the two blood vessel connecting pieces. A plurality of groups of V-shaped grooves which are annularly arranged at equal intervals are formed in the outer side surface of the annular sheet; a central column is arranged between the two groups of blood vessel connecting pieces, and the central column is positioned in the blood vessel main body; according to the vascular anastomosis device for the vascular surgery department, rapid and accurate butt joint is conducted on a blood vessel body through cooperation of the blood vessel connecting piece, the annular piece, the central column and the auxiliary clamping piece, the accuracy of alignment of a blood vessel fracture is ensured, eversion suture is achieved, and therefore the quality of an anastomotic stoma is improved, rapid and accurate connection of vascular anastomosis is achieved, and the success rate of vascular anastomosis is increased. The blood vessel reconstruction time can be shortened to one minute, the non-hepatic stage in the operation is greatly reduced, and the burden on the heart, lung and other organs of a patient is relieved.

An angiographic examination procedure for generating at least one 2-D projection image of a vascular system (20, 23) in a body region of interest of a patient (6) with an angiography system (1 to 4) characterized by the following steps: S1 Acquisition of a volume dataset of the body region of interest including the vascular system (23), S2 Reconstruction of a 3-D volume (22) from the volume dataset with the vascular system (23), S3 forward projection (24) to generate a virtual projection (25) with the vessels (20), S4 Derivation of a binary vascular mask (26) from the virtual projection (25), S5 Acquisition of at least one recent 2-D image (27), S6 Combination of the binary vascular mask (25) with at least one current 2D image (27) to form a current mask (28), S7 Threshold calculation (29) of the current mask (28) to form a current binary mask (30), S8 Backprojection (31) of the current binary mask (30) into the 3-D volume (22) to form a mask volume (32), S9 Threshold segmentation (33) of the mask volume (32) to create a final virtual vessel volume (34) and S10 Subtraction of a projection of the vessel volume (34) from the current 2-D images (27) to generate a selective non-overlapping representation of the body region of interest with selectable parameters.

The method for acquiring three-compartment data includes: acquiring multiple sets of training data, wherein each set of training data includes three-compartment data and electrical data of a collection area of ​​biological tissue acquired within the same sampling period. The three-compartment data includes the extracellular space volume fraction, cell volume fraction, and blood vessel volume fraction of each voxel point in the collection area, and the electrical data is related to the electrical impedance of the biological tissue; training a computational model using multiple sets of training data, enabling the computational model to achieve the mapping between electrical data and three-compartment data; acquiring the electrical data of a target area of ​​the biological tissue, the target area being the same size and shape as the collection area; and inputting the acquired electrical data of the target area into the trained computational model to obtain the three-compartment data of the target area. This acquisition method can directly obtain three-compartment data from electrical data, reducing the complexity of three-compartment data acquisition. This invention also provides a probe and a system for acquiring three-compartment data.

The invention belongs to the field of intelligent medical treatment, and particularly relates to a construction method and equipment of an intractable mycoplasma pneumonia prediction model. The method comprises the following steps: acquiring a data set of baseline time and a follow-up time label of a mycoplasma pneumoniae patient; inputting the image data set into a pulmonary blood vessel segmentation model to obtain a pulmonary blood vessel network, obtaining a total pulmonary blood vessel volume based on the pulmonary blood vessel network, and obtaining blood vessel volumes of different cross section areas based on the blood vessel cross section areas in the pulmonary blood vessel network; and inputting the ratio of the blood vessel volume of different cross section areas to the total pulmonary blood vessel volume into a machine learning model to obtain a prediction label, and iteratively optimizing the machine learning model based on the difference between the prediction label and the follow-up time label to obtain an intractable mycoplasma pneumonia prediction model. According to the method, the lung CT image is segmented to obtain the blood vessel network graph, the percentage of the volume of blood vessels with different thicknesses in the total lung blood vessel volume is obtained through quantification, and the refractory pneumonia prediction model is constructed based on an innovative feature extraction mode.

The invention relates to a dynamic blood vessel phantom suitable for a digital subtraction angiography technology and a working method, and belongs to the field of medical imaging system quality control. The phantom comprises a piezoelectric pump, a replaceable phantom module and a pump cover. The replaceable phantom is connected with the stand column on the right side of the piezoelectric pump through the hole in the left side. The pump cover is connected with an opening in the upper portion of the piezoelectric pump through a stand column below the pump cover; the replaceable phantom is connected with the hole in the right side of the pump cover through the stand column on the left side. The driving method comprises the steps that the piezoelectric vibrator in the piezoelectric pump periodically vibrates under the action of continuous triangular waveform voltage, the volume of a pump cavity is periodically changed, then pressure difference is periodically generated on the two sides of the one-way valve, and liquid is pumped in and pumped out under the action of the pressure difference. The dynamic process of expansion and contraction of a real blood vessel in a normal physiological state can be simulated, and the method has a good application prospect in the field of quality control of a digital subtraction angiography technology.