122 results about "Vascular prosthesis" patented technology

The present invention relates to a method for preparing a valved artificial blood vessel. The valved artificial blood vessel is a tubular fabric with a valve inside, comprising an outer tube and an inner tube connected to each other. The outer tube is a cylindrical tube. When the inner tube is unfolded, it is composed of three identical quasi-rectangular shapes, the quasi-rectangular shapes differing from rectangles only in that the upper and lower edges are curved edges. The upper edges of the three quasi-rectangular shapes are free edges, while the lower edges and straight edges are respectively fixed to the inner wall of the outer tube. First, a pattern image of the valved artificial blood vessel is input into weaving CAD software, and then the design is set according to the fabric density. Then, a process is performed to match each part of the valved artificial blood vessel pattern image with the tissue in a needle organization table, thereby generating a pattern pattern in the weaving CAD software. Finally, the pattern pattern is imported into a loom system of a jacquard loom for integrated weaving to obtain the product. The seamless valved artificial blood vessel of the present invention does not suffer from stress concentration at the suture site, thereby greatly improving tear resistance.

The utility model provides an integrated stent-type artificial blood vessel which comprises an artificial blood vessel part comprising an artificial blood vessel main branch used for being arranged corresponding to an ascending aorta of a human body; the covered stent comprises a covered stent trunk and a left subclavian artery branch arranged beside the covered stent trunk and communicated with the covered stent trunk; the bendable connecting tube section is arranged between the artificial blood vessel part and the covered stent, the bendable connecting tube section comprises a main tube section and a side short tubular joint which is arranged on the side of the main tube section and communicated with the main tube section, and in the main blood flow direction of the artificial blood vessel, the near end of the main tube section is connected with the main branch of the artificial blood vessel; the far end of the main pipe section is connected with the near end of the artificial blood vessel main branch, and the axial height of the side short pipe-shaped connector is smaller than that of the left subclavian artery branch. The number of branch arteries needing to be dissociated in an operation is reduced, then dissociation anastomosis time is saved, circulation stopping time is shortened, protection on brain tissue is enhanced, and postoperative rehabilitation of a patient is facilitated.

An integrated stent-type artificial blood vessel, comprising: an artificial blood vessel portion (1), wherein the artificial blood vessel portion (1) comprises a main artificial blood vessel trunk (11), and the main artificial blood vessel trunk (11) is configured to be arranged corresponding to an ascending aorta of a human body; a covered stent (2), wherein the covered stent (2) comprises a main covered stent trunk (21) and a left subclavian artery branch trunk (22) provided on the side of and in communication with the main covered stent trunk (21); and a bendable connecting tube segment (3), provided between the artificial blood vessel portion (1) and the covered stent (2), wherein the bendable connecting tube segment (3) comprises a main tube segment (31) and a short side tubular connector (32) provided beside and in communication with the main tube segment (31). In a primary blood flow direction of the artificial blood vessel, the proximal end of the main tube segment (31) is connected to the main artificial blood vessel trunk (11), the distal end of the main tube segment (31) is connected to the proximal end of the main covered stent trunk (21), and the short side tubular connector (32) is connected to a short covered tubular stent (23).

The application discloses a kind of artificial blood vessel texturing shaping equipment, the equipment under the extrusion of inner and outer mould, make artificial blood vessel blank pipe realize stable, uniform, continuous texturing process, after the heating of outer mould buckling, make artificial blood vessel realize shaping.This equipment can avoid the occurrence of artificial blood vessel in texturing process twist phenomenon, improve the compliance and appearance consistency of blood vessel, ensure the stability of artificial blood vessel production quality, and heat shaping in texturing process, one-time realization of the texturing and shaping process of blood vessel, save time and effort, improve artificial blood vessel production efficiency.

The invention relates to the field of medical instruments and public health, in particular to an artificial blood vessel with anticoagulation, endothelium promotion and bending resistance functions and a preparation method of the artificial blood vessel, and the artificial blood vessel is used for various blood vessel replacement and blood vessel bypass operations and has the characteristics of anticoagulation, endothelium promotion and bending resistance. The copper-containing material and the degradable magnesium-based metal material are respectively integrated on the inner surface of the artificial blood vessel and in the interlayer of the vessel wall, so that the functions of anticoagulation, endothelium promotion and bending resistance of the artificial blood vessel are realized. According to the artificial blood vessel with the anticoagulation, endothelium promotion and bending resistance functions, in the initial stage of use, due to the spiral structure of the magnesium alloy wire, the blood vessel cannot collapse after being bent, the blood flow is kept smooth, copper ions, magnesium ions and a small amount of hydrogen can be released to surrounding tissues in the use process, the microenvironment of the surrounding tissues is adjusted to be alkalescent, and the blood circulation is kept smooth. Through the synergistic effect of the copper ions and the magnesium alloy, the effects of promoting endothelialization, resisting blood coagulation and adjusting the acid-base property of the microenvironment are achieved at the same time, and therefore the functions of resisting blood coagulation, promoting endothelium and resisting bending are achieved.

The invention belongs to the technical field of polymer additive manufacturing, and discloses a conical tube type artificial blood vessel preparation method based on melt electrostatic direct writing, which comprises the following steps: firstly, determining macrostructure parameters of a conical tube type artificial blood vessel, then constructing a fan-ring-shaped side surface expansion view of the conical tube type artificial blood vessel, and finally, carrying out melt electrostatic direct writing in the constructed side surface expansion view. A fiber deposition path curve used for melt electrostatic direct-writing processing is designed, a control mapping relation between the fiber deposition path curve and axial movement of a printing platform, circumferential rotation of a taper pipe model and vertical movement of a printing head is derived, and then melt electrostatic direct-writing printing equipment is driven to conduct printing based on a control command of the mapping relation. Finally, the printed conical tube type degradable polymer skeleton is subjected to film covering treatment, and the conical tube type artificial blood vessel is obtained. Smooth and continuous caliber connection with a host blood vessel can be achieved, so that blood flow keeps a more stable speed and pressure change trend at the joint, and the flow adaptability and sealing reliability of an anastomotic stoma are improved.

The invention relates to the technical field of medical instruments, in particular to a variable-diameter blood seepage prevention artificial blood vessel based on a multi-layer composite structure, which comprises a composite artificial blood vessel main body, and a bioactive composite layer is arranged on the outer side of a gradient pore polyester woven layer. The main body of the composite artificial blood vessel is composed of more units such as the first artificial blood vessel part, the second artificial blood vessel part, the third artificial blood vessel part and the fourth artificial blood vessel part, and the inner diameter difference between every two adjacent units is 2.0 mm, so that the variable-diameter structure is more suitable for natural blood vessels of people clinically; in addition, the bioactive composite layer comprises type I collagen, heparin sodium and VEGF sustained release microspheres, the collagen / heparin composite layer forms a hydrated gel barrier when in contact with blood, the errhysis volume is reduced to 1 / 16 of that of a traditional product, endothelial cell migration is promoted by utilizing TiOnanotube array layer and VEGF sustained release synergy, and in addition, under the pulsating pressure of 120 mmHg, through 1 million times of cycle tests, the effective rate of the collagen / heparin composite layer is greatly increased. The structural integrity retention rate is larger than 99%, and the mechanical fatigue resistance is high.

The vascular prosthesis includes a luminal graft component that defines at least one fenestration and a crimped adapter at the at least one fenestration. The crimped adapter includes a perimeter and an opening with a diameter smaller than the diameter of the fenestration, and includes a crimped portion of generally concentric folds about the opening. The opening can move relative to the perimeter region of the crimped adapter to accommodate positioning of a branch prosthesis extending through the crimped adaptor. The vascular prosthesis is implanted in a patient to thereby treat, for example, an arterial aneurysm that spans a region of an artery that includes at least one arterial branch.

The application discloses an intraoperative stent, which comprises a main stent, an artificial blood vessel, a first outer convex stent and an inner embedding body.

It is an object of the present invention to provide a highly flexible artificial blood vessel and a method of manufacturing the artificial blood vessel. The artificial blood vessel VE of the present invention is an artificial blood vessel composed of ePTFE having nodes and fibrils formed between the nodes, wherein high-density regions R1 and low-density regions R2 are alternately provided in an axial direction D1 of the artificial blood vessel VE, in the high-density regions R1, the nodes and the fibrils are in a compressed and densely packed state in the axial direction D1, and in the low-density regions R2, the nodes and the fibrils are in a lower density state compared to the high-density region R1.

A delivery device prevents longitudinal expansion of an aortic prosthesis under compression by engagement of a clutch with a pin upon release of a handle rotating a gearing mechanism about the pin that advances the aortic prosthesis during endovascular implantation at a surgical site.

The application provides a preparation method of an elastomer material, a leakage-proof artificial blood vessel and a preparation method thereof, and belongs to the field of biomedical materials. Polyethylene glycol, hexamethylene diisocyanate and dibutyl tin dilaurate are dissolved in a mixed solution of a first solvent and tetrahydrofuran, a precursor solution is obtained after oil bath reaction at 50-80 DEG C for 3-24 hours, then a chain extender chitooligosaccharide is added for continuous reaction, and a polyurethane elastomer solution is obtained. The first solvent is one of N'N-dimethylacetamide and DMF. The application selects polyethylene glycol with good biocompatibility and degradability as a soft segment raw material, and selects chitooligosaccharide with a molecular weight of 1000-2500 as a chain extender, so that the prepared elastomer material has good in-vivo and in-vitro biocompatibility and degradability. The prepared polyurethane elastomer solution is sprayed on an artificial blood vessel, and a leakage-proof artificial blood vessel can be prepared. The tensile strength of the prepared leakage-proof artificial blood vessel is greater than or equal to 19 MPa, and the tear resistance can reach 162 kJ m ‑2 .

The present application relates to the technical field of biological tissue engineering, and particularly relates to an artificial blood vessel and a preparation method thereof. The present application creatively develops an artificial blood vessel with a double-network interpenetrating structure based on a design of space-time coupling, wherein a double-layered openwork scaffold serves as a space maintenance network, and a porous hydrogel tube wall serves as a temporary filling network, so that accurate space-time adaptation of degradation and regeneration is realized. Specifically, the double-layered openwork scaffold serves as a main load-bearing framework, and the slow degradation characteristic of the double-layered openwork scaffold provides independent, stable and long-term mechanical support, thereby fundamentally avoiding premature degradation of mechanical properties. Meanwhile, the fast-degrading hydrogel tube wall ensures the airtightness of the blood vessel in the early stage after implantation, and then degrades rapidly to leave a preset and through three-dimensional space for tissue regeneration, thereby ensuring the speed and integrity of the regeneration.

This invention relates to a conveying system, which includes a sheath assembly and a handle assembly. The sheath assembly includes an outer sheath and an inner sheath, with the outer sheath sleeved over the inner sheath and the distal end of the inner sheath disposed within the outer sheath. The handle assembly includes a sliding assembly and an elastic element. The sliding assembly includes a driving element, an outer tube connector, and an inner tube connector. The proximal end of the outer sheath is connected to the inner tube connector after passing through it, and the proximal end of the inner sheath is connected to the inner tube connector. The elastic element is disposed at the proximal end of the driving element. When a force is applied, the driving element moves towards its proximal end, causing the outer tube connector to move towards its proximal end. The elastic element deforms, and the movement of the outer tube connector causes the outer sheath to move towards its proximal end. When the force is removed, the outer sheath and the outer tube connector remain stationary relative to the handle assembly. The elastic element returns to its original shape and causes the driving element to move towards its distal end to reset. Subsequently, when a force is applied again, the driving element moves towards its proximal end, causing the inner tube connector to move towards its proximal end. The elastic element deforms, and the movement of the inner tube connector causes the inner sheath to move towards its proximal end. The delivery system of this invention can quickly connect native blood vessels and artificial blood vessels, improve surgical efficiency, effectively shorten surgical time, and provide convenient and quick visual operation.

The application discloses an artificial blood vessel stent with anticoagulation performance and a construction method thereof. After a pig heart aorta blood vessel is subjected to decellularization treatment, a pre-gel solution is prepared by compounding polyvinyl alcohol and methacrylated gelatin, a designed model is printed into a hollow tubular mold by using 3D printing, the pre-gel solution is injected into the mold to obtain an artificial blood vessel stent with controllable shape and size after cross-linking, and finally, the artificial blood vessel stent loaded with heparin is obtained by loading the heparin on the prepared stent. The material for preparing the pre-gel solution is selected, and the advantages of the material functions can be complemented. The decellularized matrix is beneficial to cell adhesion, proliferation and differentiation; the compounding of polyvinyl alcohol and methacrylated gelatin improves the mechanical properties of the stent and improves the cell adhesion. The heparin is loaded on the artificial blood vessel stent to improve the anticoagulation performance of the stent and prevent the formation of thrombus. The stent serves as an excellent biomedical material and has a wide application prospect in the fields of cardiovascular tissue engineering and biology.

The invention relates to the field of medical instruments, in particular to a central vein hybridization stent conveying system which comprises a conveyor and a hybridization stent. The conveyor comprises a sheath core assembly, a sheath tube and a stay wire releaser, and the stay wire releaser comprises a first stay wire and a second stay wire; the hybrid stent comprises a stent and an artificial blood vessel which are separated from each other, and the far end side of the artificial blood vessel and the near end of the stent at least partially coincide in the axial direction; the sheath core assembly is sleeved with the support, and the support is located in the sheath tube. The far end side of the first pull wire is wound and bound on the support. The sheath core assembly is sleeved with the artificial blood vessel, the sheath core assembly is located in the sheath tube, the far-end side of the second pull wire winds and restrains the artificial blood vessel, or the conveyor further comprises a wrapping film, the wrapping film wraps the artificial blood vessel so that the artificial blood vessel can be fixedly arranged on the periphery of the sheath tube in a sleeving mode, and the far-end side of the second pull wire is connected with the wrapping film. By means of the structure, damage to the artificial blood vessel and the stent in the preoperative connection process can be avoided, and meanwhile due to the fact that the connection technology is omitted, the device process of the hybrid stent can be simplified.

The purpose of the present invention is to provide an artificial blood vessel having high flexibility and a method for manufacturing the artificial blood vessel. An artificial blood vessel (VE) according to the present invention is an artificial blood vessel (VE) comprising expanded polytetrafluoroethylene having nodes and fibrils formed between the nodes, in which high-density regions (R1) and low-density regions (R2) are alternately provided in the axial direction (D1) of the artificial blood vessel (VE), the high-density region (R1) is a region in which nodes and fibrils are compressed and dense in the axial direction (D1), and the low-density region (R2) is a region in which nodes and fibrils are in a lower-density state than the high-density region (R1).

The invention discloses a tubular fiber-reinforced biological composite artificial blood vessel stent with a degradable metamaterial structure. A reinforcing phase of the biological composite material artificial blood vessel stent is a tubular fiber network stent, and a matrix phase is hydrogel; the tube wall of the tubular fiber network stent is of a negative Poisson's ratio structure, and the negative Poisson's ratio structure is constructed by a fiber network formed by mutually crossing fibers; the mechanical property of the biological composite material is changed by regulating and controlling the structural parameters of the tubular fiber network stent, so that the strength of the natural blood vessel is matched with the compliance mechanical property. The problems that in the prior art, the mechanical property of a small-caliber artificial blood vessel is not matched with that of a natural artery, the compliance is insufficient, and precise regulation and control of the mechanical property are difficult to achieve are solved.

The application provides a preparation method of an endothelium matrix vascular prosthesis. The method comprises the following steps: injecting a cell suspension into the inner wall of the vascular prosthesis to adhere, then supplying a culture medium under a perfusion circulation system to simulate an in-vivo vascular environment, so that an endothelium tissue is formed on the inner wall of the vascular prosthesis, and finally, the endothelium tissue vascular prosthesis is subjected to a decellularization treatment to obtain the endothelium matrix vascular prosthesis. The method can provide elasticity and mechanical properties for the vascular prosthesis by using a cell internal growth technology, and meanwhile, the adhesion and growth of cells are induced by using the topological structure of the vascular prosthesis. The method improves the biocompatibility of the vascular prosthesis while performing the endothelium matrix treatment on the vascular prosthesis, and finally, a biological vascular prosthesis with high elasticity, high mechanical strength and high biocompatibility is obtained.

The present disclosure relates generally to methods for reducing a post-curl profile of a medical device, in particular to methods for reducing a post-curl profile of a prosthetic heart valve, and even more particularly to facilitating a desired folding profile of a leaflet of the prosthetic heart valve during curl of a frame of the prosthetic heart valve, methods of reducing the number and volume of void spaces between and around the leaflets, and reducing the post-curl outer diameter profile of the prosthetic heart valve, while reducing the risk of damage to the leaflets and other components of the prosthetic heart valve during the curl process. Methods for reducing the post-curl profile of a prosthetic heart valve may be accomplished by non-simultaneous and / or non-uniform curl of a valve frame during the curl process.

Disclosed in the present invention are a long-acting functionalized double-layer bionic small-caliber vascular prosthesis, and a preparation method therefor and use thereof. The preparation method therefor comprises: separately synthesizing degradable polyurethane elastomers PCHU-DSeSe and PCHU-DTA using a three-step solution polymerization method, and carrying out near-field direct-writing electrospinning of PCHU-DSeSe on a stainless steel mandrel with an axial groove to obtain an axially oriented fibrous vascular inner layer; assembling the axially oriented fibrous vascular inner layer together with the mandrel into a polytetrafluoroethylene mold having radially oriented patterns on the inner wall of the housing; rapidly casting a PCHU-DTA / DMSO solution into the mold for phase separation to obtain a vascular outer layer of an axis-aligned topological microstructure, and carrying out freeze-drying to obtain the long-acting functionalized double-layer bionic small-caliber vascular prosthesis. The long-acting functionalized double-layer bionic small-caliber vascular prosthesis has the functions of continuous release of DSS, NO and H2S, and in-situ dynamic regulation and repair of a vascular tissue microenvironment, can be used for arteriovenous fistula creation, and coronary artery and peripheral vascular bypass therapy, and thus has good application prospects.

The present invention provides a vascular reinforcing device for anastomosis and a stapler for anastomosis, which, when the aorta and an artificial blood vessel are anastomosed to replace a part of the aorta with the artificial blood vessel, disposes respective reinforcing devices inside and outside the end portion of the aorta to which the artificial blood vessel is anastomosed, so as to reinforce the tissues of the aorta and maintain the shape thereof such that anastomosis with the artificial blood vessel can be facilitated. The reinforcing device for reinforcing a blood vessel to be anastomosed comprises: a first reinforcing device formed in a shape corresponding to the inner shape of the blood vessel, and disposed on the inside of the blood vessel; and a second reinforcing device formed in a shape corresponding to the outer shape of the blood vessel, and disposed on the outside of the blood vessel.

A vascular simulator based on pulsatile flow control and a method for controlling same are disclosed. The control method according to the present disclosure may comprise the steps of: acquiring pressure sensing information of an artificial blood vessel outlet region due to the flow of artificial blood through a pressure sensor corresponding to the artificial blood vessel outlet region; identifying an outlet pressure corresponding to the artificial blood vessel outlet region on the basis of the pressure sensing information; if the outlet pressure is identified, identifying whether the outlet pressure matches a preset condition; and if the outlet pressure does not match the preset condition, controlling a valve corresponding to the outlet such that the outlet pressure matches the preset condition.

The invention relates to the technical field of artificial blood vessel manufacturing, and particularly discloses an artificial blood vessel printing method and device. The artificial blood vessel printing device comprises a first liquid storage component used for storing a core phase material; the second liquid storage part is used for storing an external phase material; the coaxial printing assembly is provided with an inner material pipe and an outer material pipe which are coaxially arranged, the inner material pipe is connected with the first liquid storage component, and the outer material pipe is connected with the second liquid storage component; the pressure source is communicated with the first liquid storage component and the second liquid storage component and is used for providing pressure; the receiving part is arranged below the coaxial printing assembly and used for receiving the artificial blood vessel; the light curing assembly is arranged on one side of the receiving part and used for curing the artificial blood vessel; by using the method, complex anatomical characteristics of natural tubular tissues can be reproduced, and generation of tiny thrombus can be prevented; and microchannel blockage can be effectively avoided, the influence on the preparation precision and efficiency is avoided, and the biocompatibility and high mechanical strength of the vascular structure can be considered.

The invention relates to a conveying system which comprises a sheath tube assembly and a handle assembly, the sheath tube assembly comprises an outer sheath tube, the handle assembly comprises a shell, a key, a sliding assembly, a sleeve and an elastic piece, the near end side of the sheath tube assembly is arranged in the shell, part of the sliding assembly, part of the sleeve and part of the elastic piece are arranged in the shell, the key is exposed out of the shell, and the outer sheath tube is arranged in the shell. The elastic part is arranged on the outer sheath tube and matched with the sliding assembly, the sliding assembly is matched with the sleeve, the sleeve fixedly sleeves the near-end side of the outer sheath tube, and the elastic part abuts against the sliding assembly; force is applied to the key to enable the key to move towards the near end relative to the shell so as to drive the sliding assembly to move towards the near end, the sliding assembly moves towards the near end, the elastic piece can be deformed, the sleeve can be driven to move towards the near end, the sleeve moves towards the near end to drive the outer sheath tube to move towards the near end, and after the force applied to the key is removed, the outer sheath tube is driven to move towards the near end. The outer sheath tube is static relative to the shell, the elastic piece restores to drive the sliding assembly to reset towards the far end, and the sliding assembly resets towards the far end to drive the key to reset towards the far end. The delivery system can rapidly connect the native blood vessel and the artificial blood vessel, the operation efficiency is improved, the operation time is effectively shortened, and visual operation is convenient and rapid.

The application provides a blood pump, which comprises a pump shell, a pipeline assembly and an impeller, the pump shell is provided with a receiving cavity; the pipeline assembly comprises a liquid outlet pipe communicated with the receiving cavity, the liquid outlet pipe is provided with a liquid outlet, the pipeline assembly is further provided with a liquid inlet, the liquid inlet is communicated with the receiving cavity, the pipeline assembly can be arranged on the ventricular wall so that the liquid inlet is located in the ventricle, the liquid outlet pipe has a certain length, so that when the pipeline assembly is arranged on the ventricular wall, the liquid outlet pipe can extend to the aortic valve through the ventricle, and the liquid outlet is located in the aorta; the impeller is rotatably arranged in the receiving cavity, so that the liquid in the receiving cavity from the liquid inlet can flow out from the liquid outlet through the liquid outlet pipe. The blood pump provided by the application can pump the blood in the ventricle to the aorta without setting an artificial blood vessel, avoids the aortic diseases such as dissection and hematoma caused by the hole on the aorta, and reduces the operation difficulty. The application further provides a ventricular assist system.

The utility model relates to an artificial blood vessel thrombus removing device which comprises an inner core, an inner sheath, an outer sheath, a hemostasis valve, a liquid supply device and an air bag filling device, and a liquid inlet and outlet guide pipe arranged at the front end of the inner sheath comprises a guide pipe wall and a net-shaped self-expansion type elastic memory alloy metal wire support. The defects of large trauma, high cost, low thrombus suction efficiency and the like existing in an existing artificial blood vessel thrombus treatment mode are overcome, the liquid inlet and outlet guide pipe is arranged at the front end of the inner sheath, the net-shaped self-expansion type elastic memory alloy metal wire support is arranged in the liquid inlet and outlet guide pipe, the net-shaped self-expansion type elastic memory alloy metal wire support can drive the liquid outlet end of the inner sheath to be unfolded when unfolded, and the thrombus suction efficiency is improved. Through operation cooperation of the two artificial blood vessel thrombus removing devices, the artificial blood vessel thrombus removing device has the advantages of being minimally invasive, convenient to use, economical and capable of efficiently removing artificial blood vessel arteriovenous fistula thrombus.

To provide an access port capable of suppressing or reducing the occurrence of coring, and also provide a vascular access device capable of achieving that.SOLUTION: An access port 92 comprises a vascular access part 921 and a surrounding part 926 that surrounds the periphery of the vascular access part 921. The tensile modulus of the vascular access part 921 is greater than the tensile modulus of the surrounding part 926. Accordingly, when a needle is inserted into the vascular access part 921, the frequency of occurrence of elastomer fragments that may be produced by scraping of the vascular access part 921 can be reduced. That is, the occurrence of coring can be suppressed or reduced. Meanwhile, a vascular access device 9 comprises the access port 92 and an artificial blood vessel 91.SELECTED DRAWING: Figure 1A