65 results about "Vascular prosthesis" patented technology

The application discloses a kind of artificial blood vessel texturing shaping equipment, the equipment under the extrusion of inner and outer mould, make artificial blood vessel blank pipe realize stable, uniform, continuous texturing process, after the heating of outer mould buckling, make artificial blood vessel realize shaping.This equipment can avoid the occurrence of artificial blood vessel in texturing process twist phenomenon, improve the compliance and appearance consistency of blood vessel, ensure the stability of artificial blood vessel production quality, and heat shaping in texturing process, one-time realization of the texturing and shaping process of blood vessel, save time and effort, improve artificial blood vessel production efficiency.

The invention belongs to the technical field of polymer additive manufacturing, and discloses a conical tube type artificial blood vessel preparation method based on melt electrostatic direct writing, which comprises the following steps: firstly, determining macrostructure parameters of a conical tube type artificial blood vessel, then constructing a fan-ring-shaped side surface expansion view of the conical tube type artificial blood vessel, and finally, carrying out melt electrostatic direct writing in the constructed side surface expansion view. A fiber deposition path curve used for melt electrostatic direct-writing processing is designed, a control mapping relation between the fiber deposition path curve and axial movement of a printing platform, circumferential rotation of a taper pipe model and vertical movement of a printing head is derived, and then melt electrostatic direct-writing printing equipment is driven to conduct printing based on a control command of the mapping relation. Finally, the printed conical tube type degradable polymer skeleton is subjected to film covering treatment, and the conical tube type artificial blood vessel is obtained. Smooth and continuous caliber connection with a host blood vessel can be achieved, so that blood flow keeps a more stable speed and pressure change trend at the joint, and the flow adaptability and sealing reliability of an anastomotic stoma are improved.

The application discloses an intraoperative stent, which comprises a main stent, an artificial blood vessel, a first outer convex stent and an inner embedding body.

The present application relates to the technical field of biological tissue engineering, and particularly relates to an artificial blood vessel and a preparation method thereof. The present application creatively develops an artificial blood vessel with a double-network interpenetrating structure based on a design of space-time coupling, wherein a double-layered openwork scaffold serves as a space maintenance network, and a porous hydrogel tube wall serves as a temporary filling network, so that accurate space-time adaptation of degradation and regeneration is realized. Specifically, the double-layered openwork scaffold serves as a main load-bearing framework, and the slow degradation characteristic of the double-layered openwork scaffold provides independent, stable and long-term mechanical support, thereby fundamentally avoiding premature degradation of mechanical properties. Meanwhile, the fast-degrading hydrogel tube wall ensures the airtightness of the blood vessel in the early stage after implantation, and then degrades rapidly to leave a preset and through three-dimensional space for tissue regeneration, thereby ensuring the speed and integrity of the regeneration.

This invention relates to a conveying system, which includes a sheath assembly and a handle assembly. The sheath assembly includes an outer sheath and an inner sheath, with the outer sheath sleeved over the inner sheath and the distal end of the inner sheath disposed within the outer sheath. The handle assembly includes a sliding assembly and an elastic element. The sliding assembly includes a driving element, an outer tube connector, and an inner tube connector. The proximal end of the outer sheath is connected to the inner tube connector after passing through it, and the proximal end of the inner sheath is connected to the inner tube connector. The elastic element is disposed at the proximal end of the driving element. When a force is applied, the driving element moves towards its proximal end, causing the outer tube connector to move towards its proximal end. The elastic element deforms, and the movement of the outer tube connector causes the outer sheath to move towards its proximal end. When the force is removed, the outer sheath and the outer tube connector remain stationary relative to the handle assembly. The elastic element returns to its original shape and causes the driving element to move towards its distal end to reset. Subsequently, when a force is applied again, the driving element moves towards its proximal end, causing the inner tube connector to move towards its proximal end. The elastic element deforms, and the movement of the inner tube connector causes the inner sheath to move towards its proximal end. The delivery system of this invention can quickly connect native blood vessels and artificial blood vessels, improve surgical efficiency, effectively shorten surgical time, and provide convenient and quick visual operation.

The invention relates to the field of medical instruments, in particular to a central vein hybridization stent conveying system which comprises a conveyor and a hybridization stent. The conveyor comprises a sheath core assembly, a sheath tube and a stay wire releaser, and the stay wire releaser comprises a first stay wire and a second stay wire; the hybrid stent comprises a stent and an artificial blood vessel which are separated from each other, and the far end side of the artificial blood vessel and the near end of the stent at least partially coincide in the axial direction; the sheath core assembly is sleeved with the support, and the support is located in the sheath tube. The far end side of the first pull wire is wound and bound on the support. The sheath core assembly is sleeved with the artificial blood vessel, the sheath core assembly is located in the sheath tube, the far-end side of the second pull wire winds and restrains the artificial blood vessel, or the conveyor further comprises a wrapping film, the wrapping film wraps the artificial blood vessel so that the artificial blood vessel can be fixedly arranged on the periphery of the sheath tube in a sleeving mode, and the far-end side of the second pull wire is connected with the wrapping film. By means of the structure, damage to the artificial blood vessel and the stent in the preoperative connection process can be avoided, and meanwhile due to the fact that the connection technology is omitted, the device process of the hybrid stent can be simplified.

The invention discloses a tubular fiber-reinforced biological composite artificial blood vessel stent with a degradable metamaterial structure. A reinforcing phase of the biological composite material artificial blood vessel stent is a tubular fiber network stent, and a matrix phase is hydrogel; the tube wall of the tubular fiber network stent is of a negative Poisson's ratio structure, and the negative Poisson's ratio structure is constructed by a fiber network formed by mutually crossing fibers; the mechanical property of the biological composite material is changed by regulating and controlling the structural parameters of the tubular fiber network stent, so that the strength of the natural blood vessel is matched with the compliance mechanical property. The problems that in the prior art, the mechanical property of a small-caliber artificial blood vessel is not matched with that of a natural artery, the compliance is insufficient, and precise regulation and control of the mechanical property are difficult to achieve are solved.

The application provides a preparation method of an endothelium matrix vascular prosthesis. The method comprises the following steps: injecting a cell suspension into the inner wall of the vascular prosthesis to adhere, then supplying a culture medium under a perfusion circulation system to simulate an in-vivo vascular environment, so that an endothelium tissue is formed on the inner wall of the vascular prosthesis, and finally, the endothelium tissue vascular prosthesis is subjected to a decellularization treatment to obtain the endothelium matrix vascular prosthesis. The method can provide elasticity and mechanical properties for the vascular prosthesis by using a cell internal growth technology, and meanwhile, the adhesion and growth of cells are induced by using the topological structure of the vascular prosthesis. The method improves the biocompatibility of the vascular prosthesis while performing the endothelium matrix treatment on the vascular prosthesis, and finally, a biological vascular prosthesis with high elasticity, high mechanical strength and high biocompatibility is obtained.

The present disclosure relates generally to methods for reducing a post-curl profile of a medical device, in particular to methods for reducing a post-curl profile of a prosthetic heart valve, and even more particularly to facilitating a desired folding profile of a leaflet of the prosthetic heart valve during curl of a frame of the prosthetic heart valve, methods of reducing the number and volume of void spaces between and around the leaflets, and reducing the post-curl outer diameter profile of the prosthetic heart valve, while reducing the risk of damage to the leaflets and other components of the prosthetic heart valve during the curl process. Methods for reducing the post-curl profile of a prosthetic heart valve may be accomplished by non-simultaneous and / or non-uniform curl of a valve frame during the curl process.

The present invention provides a vascular reinforcing device for anastomosis and a stapler for anastomosis, which, when the aorta and an artificial blood vessel are anastomosed to replace a part of the aorta with the artificial blood vessel, disposes respective reinforcing devices inside and outside the end portion of the aorta to which the artificial blood vessel is anastomosed, so as to reinforce the tissues of the aorta and maintain the shape thereof such that anastomosis with the artificial blood vessel can be facilitated. The reinforcing device for reinforcing a blood vessel to be anastomosed comprises: a first reinforcing device formed in a shape corresponding to the inner shape of the blood vessel, and disposed on the inside of the blood vessel; and a second reinforcing device formed in a shape corresponding to the outer shape of the blood vessel, and disposed on the outside of the blood vessel.

A vascular simulator based on pulsatile flow control and a method for controlling same are disclosed. The control method according to the present disclosure may comprise the steps of: acquiring pressure sensing information of an artificial blood vessel outlet region due to the flow of artificial blood through a pressure sensor corresponding to the artificial blood vessel outlet region; identifying an outlet pressure corresponding to the artificial blood vessel outlet region on the basis of the pressure sensing information; if the outlet pressure is identified, identifying whether the outlet pressure matches a preset condition; and if the outlet pressure does not match the preset condition, controlling a valve corresponding to the outlet such that the outlet pressure matches the preset condition.

The invention relates to the technical field of artificial blood vessel manufacturing, and particularly discloses an artificial blood vessel printing method and device. The artificial blood vessel printing device comprises a first liquid storage component used for storing a core phase material; the second liquid storage part is used for storing an external phase material; the coaxial printing assembly is provided with an inner material pipe and an outer material pipe which are coaxially arranged, the inner material pipe is connected with the first liquid storage component, and the outer material pipe is connected with the second liquid storage component; the pressure source is communicated with the first liquid storage component and the second liquid storage component and is used for providing pressure; the receiving part is arranged below the coaxial printing assembly and used for receiving the artificial blood vessel; the light curing assembly is arranged on one side of the receiving part and used for curing the artificial blood vessel; by using the method, complex anatomical characteristics of natural tubular tissues can be reproduced, and generation of tiny thrombus can be prevented; and microchannel blockage can be effectively avoided, the influence on the preparation precision and efficiency is avoided, and the biocompatibility and high mechanical strength of the vascular structure can be considered.

The invention relates to a conveying system which comprises a sheath tube assembly and a handle assembly, the sheath tube assembly comprises an outer sheath tube, the handle assembly comprises a shell, a key, a sliding assembly, a sleeve and an elastic piece, the near end side of the sheath tube assembly is arranged in the shell, part of the sliding assembly, part of the sleeve and part of the elastic piece are arranged in the shell, the key is exposed out of the shell, and the outer sheath tube is arranged in the shell. The elastic part is arranged on the outer sheath tube and matched with the sliding assembly, the sliding assembly is matched with the sleeve, the sleeve fixedly sleeves the near-end side of the outer sheath tube, and the elastic part abuts against the sliding assembly; force is applied to the key to enable the key to move towards the near end relative to the shell so as to drive the sliding assembly to move towards the near end, the sliding assembly moves towards the near end, the elastic piece can be deformed, the sleeve can be driven to move towards the near end, the sleeve moves towards the near end to drive the outer sheath tube to move towards the near end, and after the force applied to the key is removed, the outer sheath tube is driven to move towards the near end. The outer sheath tube is static relative to the shell, the elastic piece restores to drive the sliding assembly to reset towards the far end, and the sliding assembly resets towards the far end to drive the key to reset towards the far end. The delivery system can rapidly connect the native blood vessel and the artificial blood vessel, the operation efficiency is improved, the operation time is effectively shortened, and visual operation is convenient and rapid.

Disclosed are a combined artificial vascular sheath capable of reconstructing lymph node motive force, a guiding device, and a use method. The combined artificial vascular sheath comprises an elastic sheet and a plurality of tying bands connected to the elastic sheet, wherein the elastic sheet covers a vascular bundle, and the plurality of tying bands sequentially surround and bundle the vascular bundle to form a combined artificial vascular sheath wrapping the vascular bundle. The guiding device comprises a retractor, wherein the retractor is of an arc-shaped plate structure, the front end of the retractor is provided with a guide hook, and the guide hook matches a hook hole on the tying band and the opening thereof faces backwards. According to the present invention, the combined artificial vascular sheath with low elasticity is arranged on the surface of the vascular bundle to replace the damaged or hardened vascular adventitia which has lost its function, such that the function of squeezing and stimulating the peripheral lymph nodes of the blood vessel is reconstructed, and the influence on blood vessel branches is also reduced. The guiding device enables operators to conveniently implant the combined artificial vascular sheath, and has the advantages of simple structure, convenient operation and little damage to human bodies.

The invention provides a support stent and a delivery system, and the support stent is used for providing lumen support at a suture position of an autologous blood vessel and an artificial blood vessel, so that suture-free quick connection of the human blood vessel and the autologous blood vessel is realized by applying a simple suture or a bundling device outside the blood vessel. The supporting stent can be conveyed to the position where an artificial blood vessel and an autologous blood vessel are to be anastomosed and sutured through the conveying system, the conveying system comprises an enveloping part, a balloon body and a clamping part, the supporting stent is accurately and rapidly positioned in a lumen through installation and delivery of the enveloping part and in cooperation with centering positioning of the balloon body, and when the supporting stent is released, the balloon body is clamped in the clamping part. The clamping function of the clamping piece can further ensure the accurate positioning of the stent and ensure the release stability, so that the support stent can be quickly and accurately conveyed to the suturing position of the autologous blood vessel and the artificial blood vessel.

The invention discloses an artificial blood vessel preparation device and method, and relates to the technical field of medical instruments.The artificial blood vessel preparation device comprises a rack, a mandrel module, a spinning module, a knitting module and a spraying module, and the mandrel module is arranged on the rack and used for clamping and driving a mandrel to rotate and axially move; the spinning module is used for forming a spinning inner layer on the mandrel; the knitting module is used for knitting a knitting middle layer on the surface of the spinning inner layer structure; the spraying module is used for forming a spraying outer layer on the surface of the knitted middle layer structure; the spinning module, the knitting module and the spraying module are arranged in the axial direction of the mandrel and can move relative to the mandrel so that the artificial blood vessel of a three-layer composite structure can be continuously and integrally prepared. The invention further provides a preparation method which is used for solving the technical problems of insufficient elasticity, low preparation efficiency and high cost in the existing artificial blood vessel preparation process.

The invention relates to a hybridization stent conveying system for central veins. The hybridization stent conveying system comprises an outer sheath tube, a handle assembly, an inner sheath core, a pre-cutting tool, a hybridization stent and a tearable sleeve. The handle assembly comprises an outer shell and a transmission part, and the near end of the outer sheath tube penetrates through the outer shell in a sliding mode and is connected with the transmission part; the inner sheath core slidably penetrates through the outer sheath tube, and the near end of the inner sheath core is fixedly connected with the outer shell; the pre-cutting tool is arranged on the inner wall of the outer sheath tube; the intraoperative stent comprises an artificial blood vessel and an intravascular stent which are connected, and the intraoperative stent is arranged on the inner sheath core in a sleeving mode and located between the inner sheath core and the outer sheath tube after being compressed. The far end of the tearable cannula is fixedly connected with the inner wall of the outer sheath tube, and the tearable cannula is arranged on the periphery of the artificial blood vessel in a sleeving mode and constrains the artificial blood vessel after thermal shrinkage. When the transmission part drives the outer sheath tube to move towards the near end, the precutting tool cuts the tearable sleeve, and meanwhile the outer sheath tube drags the tearable sleeve to tear the tearable sleeve. According to the structure, the loading efficiency of loading the hybrid scaffold into the sheathing canal can be improved, and smooth release of the hybrid scaffold in a human body in a subsequent operation can also be ensured.

The present inventions is to produce a tissue engineered tube including a smooth muscle layer and an endothelial cell layer derived from stem cells. It is possible to produce a tissue engineered tube that generates physiological contraction and relaxation reactions by producing a tissue engineered tube using smooth muscle cells derived from stem cells at least three times or more as those used in a method of the related art, and using endothelial cells derived from stem cells. Since an artificial blood vessel produced using iPS cells derived from a Werner syndrome patient indicates being an artificial blood vessel reflecting a pathological condition, tissue engineered tubes reflecting pathological conditions of various diseases can be produced using iPS cells. The tissue engineered tube can be used in pharmaceutical screening and transplantation.

The invention relates to the field of biological manufacturing and tissue engineering, and particularly discloses a multi-biological-structure-feature artificial blood vessel manufacturing method which comprises the steps that a parameterized model of an artificial blood vessel is constructed, and the model defines multi-layer biological structure features of the blood vessel and defines the corresponding relation between the multi-layer biological structure features and a printing path; a G code for controlling cross-scale radial 3D printing is generated based on a model, and through the same rotating shaft receiving device and linkage control, integrated manufacturing of a macroscopic layered structure and a microcosmic fiber network structure is achieved in the one-time forming process. Wherein the inner elastic film and the outer elastic film with the corrugation mechanical property are accurately formed by combining unstable state coaxial extrusion with a grid type tight path; millimeter-scale fibers loaded with smooth muscle cells are stacked through a spiral large-lead path, and a middle membrane with a contraction function is constructed; a nanoscale fiber network is constructed through grid type macroscopic near-field direct-writing electrostatic spinning, and a bionic outer membrane is formed to promote cell adhesion.

The invention discloses a preparation method of an expanded polytetrafluoroethylene (ePTFE) small-caliber artificial blood vessel based on directly grafted heparin of polydopamine nanoparticles. The method comprises the following steps: performing plasma treatment on a cleaned ePTFE small-caliber artificial blood vessel, grafting PDA-NPs on the treated artificial blood vessel, activating heparin by using EDCHCl and NHS, and reacting the ePTFE / PDA / HEP small-caliber artificial blood vessel grafted with the PDA-NPs with an activated heparin solution to obtain the heparin-grafted ePTFE / PDA / HEP small-caliber artificial blood vessel. And finally, washing and freeze-drying to obtain the artificial blood vessel. By utilizing the synergistic effect of plasma treatment and PDA-NPs modification, the loading capacity and stability of heparin are remarkably improved, the prepared artificial blood vessel has excellent anti-platelet adhesion performance, extremely low hemolysis rate and good biocompatibility, no toxic coupling agent needs to be added in the whole process, the safety is high, the process is stable, and the preparation method is suitable for industrial production. The method has a wide application prospect in the field of clinical transformation of small-caliber artificial blood vessels.

The application discloses a spiral ridge artificial blood vessel preparation method, a plurality of metal wires are tightly surrounded outside a cylindrical mandrel to form a spiral ridge collector, the spiral ridge collector is fixed on an electrostatic spinning machine, and a spiral ridge artificial blood vessel is prepared by an electrostatic spinning method; the spiral ridge artificial blood vessel has a plurality of spiral ridges on an inner wall, can induce blood to generate a spiral flow, can improve blood flow speed near a wall surface and wall surface shear stress, and can reduce deposition of harmful substances on the inner wall of the blood vessel, and has important significance for reducing re-stenosis after small-diameter artificial blood vessel transplantation and improving long-term patency. The application further provides a spiral ridge artificial blood vessel prepared by the spiral ridge artificial blood vessel preparation method.

An endoprosthesis may include an expandable framework including an anchoring portion and a body portion extending axially from the anchoring portion, the body portion having a plurality of body cells; and a polymeric cover disposed on at least a portion of the expandable framework. The anchoring portion includes a first transverse flange and a second transverse flange proximate the first transverse flange, the first and second transverse flanges being configured to secure the anchoring portion at an orifice of a body lumen. The body portion includes a window through a side of the body portion, the window occupying space equivalent to at least two of the plurality of body cells. The window is devoid of the polymeric cover and any other structure within a perimeter of the window.

The application belongs to the technical field of medical devices, and discloses a multi-parameter linkage measuring and shearing equipment for artificial blood vessel suitable for aortic dissection repair, which adopts a modular integrated connection mode, and is composed of a rack, a guiding and positioning module, an integrated measuring and shearing module, a driving module, a control module and a power supply module. The modules are connected through detachable mechanical connection, electrical connection and signal connection to realize linkage and cooperation. The guiding and positioning module is fixedly connected to the front end of the rack, the integrated measuring and shearing module is slidably connected to the rack through a sliding guide mechanism and is accurately positioned with the guiding and positioning module, the driving module is embedded in the rack and is power-connected to the integrated measuring and shearing module through a transmission assembly, the control module is installed in the middle of the rack through a fixed support and is electrically connected to the integrated measuring and shearing module, the driving module and the power supply module, and the power supply module is detachably connected to the rear end of the rack to provide stable power supply for the whole equipment.

To provide an artificial blood vessel capable of preventing excessive blood leakage, also to provide an artificial blood vessel production method that enables the same.SOLUTION: An artificial blood vessel includes a tubular porous body having interconnected pores and a biodegradable material contained within the pores, and has a porosity of 10% or less. Since the artificial blood vessel not only contains a biodegradable material in the interconnected pores of the porous tube but also maintains a porosity of 10% or less, excessive leakage of blood to the outside of the artificial blood vessel can be prevented. An artificial blood vessel production method includes immersing a pre-immersion artificial blood vessel in an aqueous solution containing a water-soluble biodegradable material in a pressure-reduced environment, increasing the ambient pressure of the aqueous solution in which the pre-immersion artificial blood vessel is immersed, and insolubilizing the water-soluble biodegradable material contained in the post-immersion artificial blood vessel.SELECTED DRAWING: Figure 1

Artificial blood vessel with a warp thread (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l) and a weft thread (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l), wherein the artificial blood vessel alternately in an extension direction D2 of the weft thread (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l): a first area R1, in which the warp thread (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l) and the weft thread (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l) are woven in plain weave, a second region R2 with a first section R21 on the side of the second region R2, in which the warp thread (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l) crosses a plurality of weft threads (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l) on a surface of the artificial blood vessel, and a second section R22 on the side of the second region R2, in which the warp thread (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l) extends such that it crosses a weft thread (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l) crossed over on a surface of the artificial blood vessel, and a third region R3 with a first section R31 on the side of the third region R3, in which the warp thread (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l) crosses a plurality of weft threads (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l) on a surface of the artificial blood vessel, and a second section R32 on the side of the third region R3, in which the warp thread (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 1l) extends such that it crosses a weft thread (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l) crossed over on a surface of the artificial blood vessel, wherein the first section R21 on the side of the second region R2 is adjacent to the second section R32 on the side of the third region R3 in the extension direction D2 of the weft thread (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l), and the second section R22 on the side of the second region R2 is adjacent to the first section R31 on the side of the third region R3 in the extension direction D2 of the weft thread (2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 2h, 2i, 2j, 2k, 2l), and wherein the warp thread (1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 1h, 1i, 1j, 1k, 11) consists of a multifilament yarn.

The application discloses a degradable piezoelectric artificial blood vessel and a preparation method thereof, and relates to the technical field of artificial blood vessel preparation. The degradable piezoelectric artificial blood vessel comprises a first guide layer, which is provided in a tubular shape and defines a pipeline channel for blood circulation, is used for guiding blood flow, cell adhesion and tissue repair; a piezoelectric functional layer, which is sleeved on the outside of the first guide layer, is used for converting the radial force signal of blood pressure into an electric signal; and a second guide layer, which is arranged on the outside of the piezoelectric functional layer, is used for fixing the piezoelectric functional layer and guiding cell adhesion and tissue repair. The above design avoids the direct contact between the molecular ferroelectric material and the body fluid environment, and facilitates the molecular ferroelectric material to play the function of signal extraction in the body. The piezoelectric functional layer comprises a fiber membrane modified by a molecular ferroelectric material, and the fibers are arranged along the radial direction of the blood vessel, so that the mechanical performance of the artificial blood vessel is enhanced, and the durability of the artificial blood vessel is improved.

The application discloses a multifunctional composite artificial blood vessel and a preparation method thereof. The artificial blood vessel is a three-layer structure, comprising an inner layer, a middle layer and an outer layer. The inner layer, the middle layer and the outer layer are tightly combined and inseparable. The artificial blood vessel port is a hollow cylindrical structure. The inner layer is a hydrophilic inner layer. The middle layer is composed of a dense layer and a spiral ring support structure. The outer layer is an electrospinning layer. The composite artificial blood vessel comprises three layers: the inner layer is an electrospinning layer with good blood compatibility; the middle layer is a dense layer for providing mechanical properties and providing certain mechanical strength for the artificial blood vessel; and the outer layer is a fiber layer for contacting with tissues. The composite artificial blood vessel has good anti-leakage and anti-bending properties. In addition, compared with a traditional ePTFE blood vessel, the blood vessel has excellent blood compatibility and good flexibility. The method is simple to operate and suitable for commercial scale production. The inner diameter size range can be adjusted.