164 results about "Vascular prosthesis" patented technology

Medical appliances may be formed of multilayered constructs. The layers of the constructs may be configured with various physical properties or characteristics. The disposition and arrangement of each layer may be configured to create an overall construct with a combination of the individual properties of the layers. Constructs may be used to create vascular prostheses or other medical devices.

The present invention relates to a method for preparing a valved artificial blood vessel. The valved artificial blood vessel is a tubular fabric with a valve inside, comprising an outer tube and an inner tube connected to each other. The outer tube is a cylindrical tube. When the inner tube is unfolded, it is composed of three identical quasi-rectangular shapes, the quasi-rectangular shapes differing from rectangles only in that the upper and lower edges are curved edges. The upper edges of the three quasi-rectangular shapes are free edges, while the lower edges and straight edges are respectively fixed to the inner wall of the outer tube. First, a pattern image of the valved artificial blood vessel is input into weaving CAD software, and then the design is set according to the fabric density. Then, a process is performed to match each part of the valved artificial blood vessel pattern image with the tissue in a needle organization table, thereby generating a pattern pattern in the weaving CAD software. Finally, the pattern pattern is imported into a loom system of a jacquard loom for integrated weaving to obtain the product. The seamless valved artificial blood vessel of the present invention does not suffer from stress concentration at the suture site, thereby greatly improving tear resistance.

The utility model provides an integrated stent-type artificial blood vessel which comprises an artificial blood vessel part comprising an artificial blood vessel main branch used for being arranged corresponding to an ascending aorta of a human body; the covered stent comprises a covered stent trunk and a left subclavian artery branch arranged beside the covered stent trunk and communicated with the covered stent trunk; the bendable connecting tube section is arranged between the artificial blood vessel part and the covered stent, the bendable connecting tube section comprises a main tube section and a side short tubular joint which is arranged on the side of the main tube section and communicated with the main tube section, and in the main blood flow direction of the artificial blood vessel, the near end of the main tube section is connected with the main branch of the artificial blood vessel; the far end of the main pipe section is connected with the near end of the artificial blood vessel main branch, and the axial height of the side short pipe-shaped connector is smaller than that of the left subclavian artery branch. The number of branch arteries needing to be dissociated in an operation is reduced, then dissociation anastomosis time is saved, circulation stopping time is shortened, protection on brain tissue is enhanced, and postoperative rehabilitation of a patient is facilitated.

An integrated stent-type artificial blood vessel, comprising: an artificial blood vessel portion (1), wherein the artificial blood vessel portion (1) comprises a main artificial blood vessel trunk (11), and the main artificial blood vessel trunk (11) is configured to be arranged corresponding to an ascending aorta of a human body; a covered stent (2), wherein the covered stent (2) comprises a main covered stent trunk (21) and a left subclavian artery branch trunk (22) provided on the side of and in communication with the main covered stent trunk (21); and a bendable connecting tube segment (3), provided between the artificial blood vessel portion (1) and the covered stent (2), wherein the bendable connecting tube segment (3) comprises a main tube segment (31) and a short side tubular connector (32) provided beside and in communication with the main tube segment (31). In a primary blood flow direction of the artificial blood vessel, the proximal end of the main tube segment (31) is connected to the main artificial blood vessel trunk (11), the distal end of the main tube segment (31) is connected to the proximal end of the main covered stent trunk (21), and the short side tubular connector (32) is connected to a short covered tubular stent (23).

The application discloses a kind of artificial blood vessel texturing shaping equipment, the equipment under the extrusion of inner and outer mould, make artificial blood vessel blank pipe realize stable, uniform, continuous texturing process, after the heating of outer mould buckling, make artificial blood vessel realize shaping.This equipment can avoid the occurrence of artificial blood vessel in texturing process twist phenomenon, improve the compliance and appearance consistency of blood vessel, ensure the stability of artificial blood vessel production quality, and heat shaping in texturing process, one-time realization of the texturing and shaping process of blood vessel, save time and effort, improve artificial blood vessel production efficiency.

The invention relates to the field of medical instruments and public health, in particular to an artificial blood vessel with anticoagulation, endothelium promotion and bending resistance functions and a preparation method of the artificial blood vessel, and the artificial blood vessel is used for various blood vessel replacement and blood vessel bypass operations and has the characteristics of anticoagulation, endothelium promotion and bending resistance. The copper-containing material and the degradable magnesium-based metal material are respectively integrated on the inner surface of the artificial blood vessel and in the interlayer of the vessel wall, so that the functions of anticoagulation, endothelium promotion and bending resistance of the artificial blood vessel are realized. According to the artificial blood vessel with the anticoagulation, endothelium promotion and bending resistance functions, in the initial stage of use, due to the spiral structure of the magnesium alloy wire, the blood vessel cannot collapse after being bent, the blood flow is kept smooth, copper ions, magnesium ions and a small amount of hydrogen can be released to surrounding tissues in the use process, the microenvironment of the surrounding tissues is adjusted to be alkalescent, and the blood circulation is kept smooth. Through the synergistic effect of the copper ions and the magnesium alloy, the effects of promoting endothelialization, resisting blood coagulation and adjusting the acid-base property of the microenvironment are achieved at the same time, and therefore the functions of resisting blood coagulation, promoting endothelium and resisting bending are achieved.

The invention belongs to the technical field of polymer additive manufacturing, and discloses a conical tube type artificial blood vessel preparation method based on melt electrostatic direct writing, which comprises the following steps: firstly, determining macrostructure parameters of a conical tube type artificial blood vessel, then constructing a fan-ring-shaped side surface expansion view of the conical tube type artificial blood vessel, and finally, carrying out melt electrostatic direct writing in the constructed side surface expansion view. A fiber deposition path curve used for melt electrostatic direct-writing processing is designed, a control mapping relation between the fiber deposition path curve and axial movement of a printing platform, circumferential rotation of a taper pipe model and vertical movement of a printing head is derived, and then melt electrostatic direct-writing printing equipment is driven to conduct printing based on a control command of the mapping relation. Finally, the printed conical tube type degradable polymer skeleton is subjected to film covering treatment, and the conical tube type artificial blood vessel is obtained. Smooth and continuous caliber connection with a host blood vessel can be achieved, so that blood flow keeps a more stable speed and pressure change trend at the joint, and the flow adaptability and sealing reliability of an anastomotic stoma are improved.

The invention relates to the technical field of medical instruments, in particular to a variable-diameter blood seepage prevention artificial blood vessel based on a multi-layer composite structure, which comprises a composite artificial blood vessel main body, and a bioactive composite layer is arranged on the outer side of a gradient pore polyester woven layer. The main body of the composite artificial blood vessel is composed of more units such as the first artificial blood vessel part, the second artificial blood vessel part, the third artificial blood vessel part and the fourth artificial blood vessel part, and the inner diameter difference between every two adjacent units is 2.0 mm, so that the variable-diameter structure is more suitable for natural blood vessels of people clinically; in addition, the bioactive composite layer comprises type I collagen, heparin sodium and VEGF sustained release microspheres, the collagen / heparin composite layer forms a hydrated gel barrier when in contact with blood, the errhysis volume is reduced to 1 / 16 of that of a traditional product, endothelial cell migration is promoted by utilizing TiOnanotube array layer and VEGF sustained release synergy, and in addition, under the pulsating pressure of 120 mmHg, through 1 million times of cycle tests, the effective rate of the collagen / heparin composite layer is greatly increased. The structural integrity retention rate is larger than 99%, and the mechanical fatigue resistance is high.

The invention discloses a stent system, and relates to the technical field of medical treatment, the stent system comprises a main body stent, the main body stent comprises a support ring, an artificial blood vessel and a covered stent, and the artificial blood vessel is connected between the support ring and the covered stent; the conveyor comprises an outer sheath tube and a sheath core, the sheath core is sleeved with the outer sheath tube, a first cavity is defined by the outer sheath tube and the sheath core, the main body support is folded and contained in the first cavity, and the outer sheath tube can move in the extending direction of the sheath core relative to the sheath core so as to release the main body support. By connecting the artificial blood vessel with the covered stent, the main stent can be directly conveyed to the preset position through the conveyor, the operation does not need to be carried out under the condition of profound hypothermia circulation arrest, the operation safety of a patient is improved, the artificial blood vessel is supported through the supporting ring, the risks of folding and twisting of the artificial blood vessel can be reduced, and the operation safety is improved. The risk that the blood flow is affected due to the fact that the artificial blood vessel cannot be attached to the blood vessel wall after being released can be reduced, and the complication occurrence rate of patients is reduced.

The vascular prosthesis includes a luminal graft component that defines at least one fenestration and a crimped adapter at the at least one fenestration. The crimped adapter includes a perimeter and an opening with a diameter smaller than the diameter of the fenestration, and includes a crimped portion of generally concentric folds about the opening. The opening can move relative to the perimeter region of the crimped adapter to accommodate positioning of a branch prosthesis extending through the crimped adaptor. The vascular prosthesis is implanted in a patient to thereby treat, for example, an arterial aneurysm that spans a region of an artery that includes at least one arterial branch.

The invention relates to the technical field of compliance testing, in particular to a method for testing compliance of an artificial blood vessel based on a volumetric method. According to a traditional method, compliance is obtained by measuring the outer diameter, but measurement errors can be caused by the non-rigid tube wall of an artificial blood vessel. Liquid is fed periodically through the high-precision injection pump, the pressure difference and the liquid volume are recorded, the inner diameter change of the artificial blood vessel is calculated, and then the compliance is obtained. And the method improves the detection speed, sensitivity and stability of compliance, avoids the influence of wall thickness change and tube body tremor, is suitable for testing artificial blood vessels with complex structures, has a relative test error of less than 7%, and has high test precision.

The application discloses an intraoperative stent, which comprises a main stent, an artificial blood vessel, a first outer convex stent and an inner embedding body.

It is an object of the present invention to provide a highly flexible artificial blood vessel and a method of manufacturing the artificial blood vessel. The artificial blood vessel VE of the present invention is an artificial blood vessel composed of ePTFE having nodes and fibrils formed between the nodes, wherein high-density regions R1 and low-density regions R2 are alternately provided in an axial direction D1 of the artificial blood vessel VE, in the high-density regions R1, the nodes and the fibrils are in a compressed and densely packed state in the axial direction D1, and in the low-density regions R2, the nodes and the fibrils are in a lower density state compared to the high-density region R1.

The invention provides a covered stent which comprises a stent body and a covering film, and the covering film at least partially covers the surface of the stent body. The stent body comprises a far-end section and a near-end section in the axial direction, the far-end section is provided with a far-end opening, the near-end section is provided with a near-end opening, the far-end opening is provided with at least one saddle part protruding towards the far end, and the saddle parts are arranged to conform to the sinus part of the aortic blood vessel, so that the extending stent part is provided to support the sinus blood vessel while the coronary artery opening is avoided; the covering area of the stent on a diseased region is increased; the covering film further comprises a free section, the free section exceeds the near-end opening, the free section is used for being sutured with an artificial blood vessel or an autologous blood vessel, a complete and closed aorta blood vessel is formed after suturing, leakage is avoided, and meanwhile suturing is easy.

A delivery device prevents longitudinal expansion of an aortic prosthesis under compression by engagement of a clutch with a pin upon release of a handle rotating a gearing mechanism about the pin that advances the aortic prosthesis during endovascular implantation at a surgical site.

The application provides a preparation method of an elastomer material, a leakage-proof artificial blood vessel and a preparation method thereof, and belongs to the field of biomedical materials. Polyethylene glycol, hexamethylene diisocyanate and dibutyl tin dilaurate are dissolved in a mixed solution of a first solvent and tetrahydrofuran, a precursor solution is obtained after oil bath reaction at 50-80 DEG C for 3-24 hours, then a chain extender chitooligosaccharide is added for continuous reaction, and a polyurethane elastomer solution is obtained. The first solvent is one of N'N-dimethylacetamide and DMF. The application selects polyethylene glycol with good biocompatibility and degradability as a soft segment raw material, and selects chitooligosaccharide with a molecular weight of 1000-2500 as a chain extender, so that the prepared elastomer material has good in-vivo and in-vitro biocompatibility and degradability. The prepared polyurethane elastomer solution is sprayed on an artificial blood vessel, and a leakage-proof artificial blood vessel can be prepared. The tensile strength of the prepared leakage-proof artificial blood vessel is greater than or equal to 19 MPa, and the tear resistance can reach 162 kJ m ‑2 .

The present application relates to the technical field of biological tissue engineering, and particularly relates to an artificial blood vessel and a preparation method thereof. The present application creatively develops an artificial blood vessel with a double-network interpenetrating structure based on a design of space-time coupling, wherein a double-layered openwork scaffold serves as a space maintenance network, and a porous hydrogel tube wall serves as a temporary filling network, so that accurate space-time adaptation of degradation and regeneration is realized. Specifically, the double-layered openwork scaffold serves as a main load-bearing framework, and the slow degradation characteristic of the double-layered openwork scaffold provides independent, stable and long-term mechanical support, thereby fundamentally avoiding premature degradation of mechanical properties. Meanwhile, the fast-degrading hydrogel tube wall ensures the airtightness of the blood vessel in the early stage after implantation, and then degrades rapidly to leave a preset and through three-dimensional space for tissue regeneration, thereby ensuring the speed and integrity of the regeneration.

This invention relates to a conveying system, which includes a sheath assembly and a handle assembly. The sheath assembly includes an outer sheath and an inner sheath, with the outer sheath sleeved over the inner sheath and the distal end of the inner sheath disposed within the outer sheath. The handle assembly includes a sliding assembly and an elastic element. The sliding assembly includes a driving element, an outer tube connector, and an inner tube connector. The proximal end of the outer sheath is connected to the inner tube connector after passing through it, and the proximal end of the inner sheath is connected to the inner tube connector. The elastic element is disposed at the proximal end of the driving element. When a force is applied, the driving element moves towards its proximal end, causing the outer tube connector to move towards its proximal end. The elastic element deforms, and the movement of the outer tube connector causes the outer sheath to move towards its proximal end. When the force is removed, the outer sheath and the outer tube connector remain stationary relative to the handle assembly. The elastic element returns to its original shape and causes the driving element to move towards its distal end to reset. Subsequently, when a force is applied again, the driving element moves towards its proximal end, causing the inner tube connector to move towards its proximal end. The elastic element deforms, and the movement of the inner tube connector causes the inner sheath to move towards its proximal end. The delivery system of this invention can quickly connect native blood vessels and artificial blood vessels, improve surgical efficiency, effectively shorten surgical time, and provide convenient and quick visual operation.

The utility model relates to an outlet connecting mechanism and a ventricular assist system. The outlet connecting mechanism comprises a clamping assembly and an artificial blood vessel. The clamping assembly comprises a clamping ring and a locking piece, the clamping ring is provided with a suture hole, and the locking piece is arranged on the clamping ring and can adjust the inner diameter of the clamping ring; the artificial blood vessel comprises a main body tube section and a connecting tube section, the connecting tube section is connected to one end of the main body tube section, and the connecting tube section is arranged in the clamping ring and is in suture connection with the clamping ring through a suture hole in the clamping ring, so that the artificial blood vessel is fixedly connected with the clamping assembly without an additional structure. And the connection mode of the artificial blood vessel and the clamping assembly is simplified. When the artificial blood vessel needs to be fixed on the outlet tube of the ventricular auxiliary device, only the artificial blood vessel of the outlet connecting mechanism needs to be sleeved and assembled on the outlet tube and the clamping ring of the outlet connecting mechanism is locked, so that the tedious operation of binding by a binding wire is avoided, and the stability of connection between the artificial blood vessel and the outlet tube of the ventricular auxiliary device is improved.

The application discloses an artificial blood vessel stent with anticoagulation performance and a construction method thereof. After a pig heart aorta blood vessel is subjected to decellularization treatment, a pre-gel solution is prepared by compounding polyvinyl alcohol and methacrylated gelatin, a designed model is printed into a hollow tubular mold by using 3D printing, the pre-gel solution is injected into the mold to obtain an artificial blood vessel stent with controllable shape and size after cross-linking, and finally, the artificial blood vessel stent loaded with heparin is obtained by loading the heparin on the prepared stent. The material for preparing the pre-gel solution is selected, and the advantages of the material functions can be complemented. The decellularized matrix is beneficial to cell adhesion, proliferation and differentiation; the compounding of polyvinyl alcohol and methacrylated gelatin improves the mechanical properties of the stent and improves the cell adhesion. The heparin is loaded on the artificial blood vessel stent to improve the anticoagulation performance of the stent and prevent the formation of thrombus. The stent serves as an excellent biomedical material and has a wide application prospect in the fields of cardiovascular tissue engineering and biology.

The invention relates to the field of medical instruments, in particular to a central vein hybridization stent conveying system which comprises a conveyor and a hybridization stent. The conveyor comprises a sheath core assembly, a sheath tube and a stay wire releaser, and the stay wire releaser comprises a first stay wire and a second stay wire; the hybrid stent comprises a stent and an artificial blood vessel which are separated from each other, and the far end side of the artificial blood vessel and the near end of the stent at least partially coincide in the axial direction; the sheath core assembly is sleeved with the support, and the support is located in the sheath tube. The far end side of the first pull wire is wound and bound on the support. The sheath core assembly is sleeved with the artificial blood vessel, the sheath core assembly is located in the sheath tube, the far-end side of the second pull wire winds and restrains the artificial blood vessel, or the conveyor further comprises a wrapping film, the wrapping film wraps the artificial blood vessel so that the artificial blood vessel can be fixedly arranged on the periphery of the sheath tube in a sleeving mode, and the far-end side of the second pull wire is connected with the wrapping film. By means of the structure, damage to the artificial blood vessel and the stent in the preoperative connection process can be avoided, and meanwhile due to the fact that the connection technology is omitted, the device process of the hybrid stent can be simplified.

The purpose of the present invention is to provide an artificial blood vessel having high flexibility and a method for manufacturing the artificial blood vessel. An artificial blood vessel (VE) according to the present invention is an artificial blood vessel (VE) comprising expanded polytetrafluoroethylene having nodes and fibrils formed between the nodes, in which high-density regions (R1) and low-density regions (R2) are alternately provided in the axial direction (D1) of the artificial blood vessel (VE), the high-density region (R1) is a region in which nodes and fibrils are compressed and dense in the axial direction (D1), and the low-density region (R2) is a region in which nodes and fibrils are in a lower-density state than the high-density region (R1).

The invention discloses a tubular fiber-reinforced biological composite artificial blood vessel stent with a degradable metamaterial structure. A reinforcing phase of the biological composite material artificial blood vessel stent is a tubular fiber network stent, and a matrix phase is hydrogel; the tube wall of the tubular fiber network stent is of a negative Poisson's ratio structure, and the negative Poisson's ratio structure is constructed by a fiber network formed by mutually crossing fibers; the mechanical property of the biological composite material is changed by regulating and controlling the structural parameters of the tubular fiber network stent, so that the strength of the natural blood vessel is matched with the compliance mechanical property. The problems that in the prior art, the mechanical property of a small-caliber artificial blood vessel is not matched with that of a natural artery, the compliance is insufficient, and precise regulation and control of the mechanical property are difficult to achieve are solved.

The application provides a preparation method of an endothelium matrix vascular prosthesis. The method comprises the following steps: injecting a cell suspension into the inner wall of the vascular prosthesis to adhere, then supplying a culture medium under a perfusion circulation system to simulate an in-vivo vascular environment, so that an endothelium tissue is formed on the inner wall of the vascular prosthesis, and finally, the endothelium tissue vascular prosthesis is subjected to a decellularization treatment to obtain the endothelium matrix vascular prosthesis. The method can provide elasticity and mechanical properties for the vascular prosthesis by using a cell internal growth technology, and meanwhile, the adhesion and growth of cells are induced by using the topological structure of the vascular prosthesis. The method improves the biocompatibility of the vascular prosthesis while performing the endothelium matrix treatment on the vascular prosthesis, and finally, a biological vascular prosthesis with high elasticity, high mechanical strength and high biocompatibility is obtained.

The present disclosure relates generally to methods for reducing a post-curl profile of a medical device, in particular to methods for reducing a post-curl profile of a prosthetic heart valve, and even more particularly to facilitating a desired folding profile of a leaflet of the prosthetic heart valve during curl of a frame of the prosthetic heart valve, methods of reducing the number and volume of void spaces between and around the leaflets, and reducing the post-curl outer diameter profile of the prosthetic heart valve, while reducing the risk of damage to the leaflets and other components of the prosthetic heart valve during the curl process. Methods for reducing the post-curl profile of a prosthetic heart valve may be accomplished by non-simultaneous and / or non-uniform curl of a valve frame during the curl process.

Disclosed in the present invention are a long-acting functionalized double-layer bionic small-caliber vascular prosthesis, and a preparation method therefor and use thereof. The preparation method therefor comprises: separately synthesizing degradable polyurethane elastomers PCHU-DSeSe and PCHU-DTA using a three-step solution polymerization method, and carrying out near-field direct-writing electrospinning of PCHU-DSeSe on a stainless steel mandrel with an axial groove to obtain an axially oriented fibrous vascular inner layer; assembling the axially oriented fibrous vascular inner layer together with the mandrel into a polytetrafluoroethylene mold having radially oriented patterns on the inner wall of the housing; rapidly casting a PCHU-DTA / DMSO solution into the mold for phase separation to obtain a vascular outer layer of an axis-aligned topological microstructure, and carrying out freeze-drying to obtain the long-acting functionalized double-layer bionic small-caliber vascular prosthesis. The long-acting functionalized double-layer bionic small-caliber vascular prosthesis has the functions of continuous release of DSS, NO and H2S, and in-situ dynamic regulation and repair of a vascular tissue microenvironment, can be used for arteriovenous fistula creation, and coronary artery and peripheral vascular bypass therapy, and thus has good application prospects.

The present invention provides a vascular reinforcing device for anastomosis and a stapler for anastomosis, which, when the aorta and an artificial blood vessel are anastomosed to replace a part of the aorta with the artificial blood vessel, disposes respective reinforcing devices inside and outside the end portion of the aorta to which the artificial blood vessel is anastomosed, so as to reinforce the tissues of the aorta and maintain the shape thereof such that anastomosis with the artificial blood vessel can be facilitated. The reinforcing device for reinforcing a blood vessel to be anastomosed comprises: a first reinforcing device formed in a shape corresponding to the inner shape of the blood vessel, and disposed on the inside of the blood vessel; and a second reinforcing device formed in a shape corresponding to the outer shape of the blood vessel, and disposed on the outside of the blood vessel.

A vascular simulator based on pulsatile flow control and a method for controlling same are disclosed. The control method according to the present disclosure may comprise the steps of: acquiring pressure sensing information of an artificial blood vessel outlet region due to the flow of artificial blood through a pressure sensor corresponding to the artificial blood vessel outlet region; identifying an outlet pressure corresponding to the artificial blood vessel outlet region on the basis of the pressure sensing information; if the outlet pressure is identified, identifying whether the outlet pressure matches a preset condition; and if the outlet pressure does not match the preset condition, controlling a valve corresponding to the outlet such that the outlet pressure matches the preset condition.