47 results about "Periprosthetic" patented technology

The invention provides a Falcarindiol derivative, preparation thereof and application of the Falcarindiol derivative in preparation of medicines for preventing and / or treating bone diseases. The structural general formula of the Falcarindiol derivative is as shown in formula I in the specification. Experimental results show that the Falcarindiol derivative can significantly inhibit osteoclast differentiation, and is expected to be used for preparing novel drugs for preventing and / or treating osteoporosis, osteoporosis fracture, osteolysis, periprosthetic osteolysis, tumor bone metastasis, inflammatory bone loss, periodontitis inflammatory bone resorption and other bone diseases. # imgabs0 #

The invention discloses fully sintered dental zirconia and a preparation method thereof, and mainly relates to the technical field of dental prostheses. Compared with the prior art, the fully-sintered dental zirconium oxide is prepared from zinc stearate, polyvinyl alcohol and composite zirconium oxide; in the preparation of the composite zirconium oxide, ethyl silicate is hydrolyzed under an alkaline condition to obtain nano silicon dioxide sol, hydroxyapatite is wrapped on the surface of zirconium oxide through the nano silicon dioxide sol, and finally, the nano silicon dioxide sol is converted from sol to gel through heat treatment and is dehydrated to form a compact coating layer. Hydroxyl in the sol is condensed to form a more stable nano silicon dioxide network structure, and finally the fully-sintered dental zirconium oxide with higher compactness, fracture toughness and bonding strength is prepared.

This invention provides a fixation device and assembly method for pericondylar fractures of the knee joint prosthesis. The knee joint prosthesis includes a femoral condyle, a tibial plateau, and a tibial pad. The femoral condyle includes an anterior condyle, two posterior condyles, and an intercondylar fossa. A fixation device is installed in the intercondylar fossa, comprising an intramedullary fixation pin and a connecting fixation block. The connecting fixation block is installed within the intercondylar fossa and engages with the force-applying end of the intramedullary fixation pin. The connecting fixation block includes a main body with a top surface facing the tibial pad and a bottom surface opposite the top surface. The bottom surface extends away from the top surface to form a protrusion, and a through hole is formed within the protrusion, which is used to accommodate and fix the force-applying end of the intramedullary fixation pin. This invention embeds the entire connecting fixation block within the intercondylar fossa, fully utilizing the existing intercondylar fossa space of the PS-type prosthesis to establish a precise channel for the intramedullary fixation pin, thereby fixing the pericondylar fracture through structural fit.

Periprosthetic bone fixation plates are disclosed including, for example, periprosthetic proximal femur plate, periprosthetic distal femur plate, periprosthetic humerus plate, periprosthetic ring plate, and periprosthetic troch plate. In use, the periprosthetic bone fixation plates are arranged and configured for use in periprosthetic fractures. That is, the periprosthetic plates include one or more features to facilitate positioning and securement of the bone fixation plate to a patients bone that previously received a surgically implanted orthopedic device or implant such as, for example, an intramedullary nail, a hip prosthesis, a knee prosthesis, etc. In use, the one or more features are designed and configured to facilitate avoidance of the previous surgically implanted orthopedic device or implant. In addition, the periprosthetic bone fixation plates are arranged and configured to facilitate plating of a longer working length as compared to existing bone fixation plates (e.g., plating from, for example, femoral condyle to greater trochanter).

A resin based material whose composition includes a light-curable mixture of monomers of no more than 35 wt. % of an ethoxylated difunctional bisphenol A dimethacrylate; of no more than 10 wt. % of a methacrylate monomer; of no more than 10 wt. % of a difunctional urethane acrylate; of no more than 0.1 wt. % of an optical brightener; of no more than 5 wt. % of silica particles having methacrylate functionalization layers and having an average particle size of less than about 200 nm; of having more than 40 wt. % of an inert glass; of no more than 15 wt. % of a heavy metal oxide; of no more than 2.5 wt. % of an ultraviolet / visible (UV / Vis) light-photo-polymerization initiator; a colorant; and a stabilizer.

FIELD: ophthalmology.SUBSTANCE: used to remove residual cortical masses that have migrated to the equatorial region after cataract extraction (CE) in patients after keratoprosthetics. To do this, the optical cylinder of the keratoprosthesis is unscrewed using a key. Residual cortical masses are visualized through the opening of the optical cylinder (OOC) and removed using a Simcoe cannula or a straight cannula with a flat tip mounted on a 10 ml syringe. The optical cylinder is screwed back in using a key.EFFECT: invention reduces the risk of developing intra- and postoperative complications and accelerates visual rehabilitation of patients by reducing the time of surgical intervention and without performing additional approaches.1 cl, 1 ex

The invention discloses a functional coating for the surface of an orthopedic implant material as well as a preparation method and application thereof, the coating comprises core-shell structure nanoparticles, copper oxide nanoparticles with the particle size of 200nm are taken as a core, and a compound of polydopamine and baicalein is taken as a shell. The preparation method comprises the following steps: dissolving baicalein in ethanol, dispersing copper oxide nanoparticles in water, mixing to obtain a suspension, adding dopamine hydrochloride, adjusting to alkalinity, and immersing the implant material matrix for reaction. The coating is applied to an orthopedic implant material for preventing and treating periprosthetic infection, and the core-shell structure of the coating can realize continuous release of baicalein and intelligent response release of copper ions in an acidic infection environment, so that the synergistic effect of early-stage antibacterial immune regulation and late-stage enhanced antibacterial is exerted; the compound has multiple functions of long-acting antibiosis, biofilm resistance, promotion of M2 polarization of macrophages and reduction of bone destruction.

The present invention discloses a fully sintered dental zirconia and a preparation method thereof, primarily relating to the technical field of dental prostheses. Compared with the prior art, the fully sintered dental zirconia of the present invention is prepared from zinc stearate, polyvinyl alcohol, and composite zirconia. In the preparation of the composite zirconia, ethyl silicate is first hydrolyzed under alkaline conditions to produce a nano-silica sol. Hydroxyapatite is then coated on the surface of the zirconia using the nano-silica sol. Finally, the nano-silica sol is transformed from a sol to a gel through heat treatment and dehydrated to form a dense coating. The hydroxyl groups in the sol condense to form a more stable nano-silica network structure, ultimately producing a fully sintered dental zirconia with higher density, fracture toughness, and bonding strength.

Periprosthetic bone plates are disclosed including, for example, a periprosthetic distal femur plate. In use, the bone plate is configured for use in periprosthetic fractures. That is, the bone plate includes one or more features to facilitate positioning and securement of the bone plate to a patient's bone that previously received a surgically implanted orthopedic implant such as, for example, an intramedullary nail, a hip prosthesis, a knee prosthesis, etc. In use, the one or more features are designed and configured to facilitate avoidance of the previous surgically implanted orthopedic implant. In addition, the bone plate is configured to facilitate percutaneous insertion of the bone plate against the patient's bone while minimizing soft tissue irritation. In addition, and / or alternatively, the bone plate is configured to provide improved contouring to facilitate better positioning of the bone plate against the patient's bone (e.g., better contouring adjacent patient's greater trochanter).

A reverse bolted greater trochanter periprosthetic plate configured to be mounted to a femur of a patient includes a central portion with an inner surface configured to face and / or contact a femoral surface of the femur; a plurality of leg portions extending from the central portion forming a claw configured to grasp a portion of the femur; and a bolt receptor portion extending from the central portion configured for receiving a bolt for securing the plate to the femur during a reverse bolted greater trochanter periprosthetic procedure.

A targeting system is disclosed. In use, the targeting system is configured to target (e.g., aim, locate, etc.) a fastener opening in a bone plate, more particularly, a variable angled fastener opening formed in a periphery of a periprosthetic bone plate. In one embodiment, the targeting system includes an alignment guide including a plurality of combo-slots for targeting a plurality of openings formed in the periprosthetic bone plate. In addition, the targeting system includes a plug configured to be positioned within the combo-slots formed in the alignment guide. In use, positioning the plug into the combo-slot formed in the alignment guide transforms the combo-slot into a substantially circular hole or opening with a predefined trajectory aligned with one of the variable angled openings formed in the periphery of the periprosthetic bone plate thereby defining a trajectory from the alignment guide to the variable angled opening.

A computerized system and method (123A-C) for the automated design and additive manufacturing of patient-specific orthopedic reconstructions (600R). The method integrates anatomically tagged medical scans, oriented relative to X, Y, and Z axes, with machine-learning models trained on aggregate historical biomechanical outcomes to generate optimized implant geometries. The system calculates an Osseointegration Probability Score (OPS) and a Comprehensive Prognostic Success Score (CPSS) to dynamically modify internal porous lattice densities, minimizing stress shielding while maximizing load-bearing capacity. The manufacturing process simultaneously generates internal longitudinal conduits for post-operative vascularization and computationally optimized structural anchors (bulges, serrations, and wings) for precise anatomical fixation. By linking real-time biomechanical simulation with prognostic clinical data, the invention provides a high-fidelity manufacturing blueprint that improves long-term implant stability and reduces periprosthetic complications.

A targeting system is disclosed. In use, the targeting system is configured to target (e.g., aim, locate, etc.) a fastener opening in a bone plate, more particularly, a variable angled fastener opening formed in a periphery of a periprosthetic bone plate. In one embodiment, the targeting system includes an alignment guide including a plurality of combo-slots for targeting a plurality of openings formed in the periprosthetic bone plate. In addition, the targeting system includes a plug configured to be positioned within the combo-slots formed in the alignment guide. In use, positioning the plug into the combo-slot formed in the alignment guide transforms the combo-slot into a substantially circular hole or opening with a predefined trajectory aligned with one of the variable angled openings formed in the periphery of the periprosthetic bone plate thereby defining a trajectory from the alignment guide to the variable angled opening.

The invention discloses a targeted periprosthetic infection detection, drug delivery and drug intervention system as well as a method and application thereof, and belongs to the field of biological medicine. The detection and drug intervention system comprises a micrococcus nuclease sensitive biological probe, a functional silicon plastid for bearing the micrococcus nuclease sensitive biological probe, light-cured hydrogel and an implant, wherein medicines are carried in the functional silica plastid; a micrococcus nuclease sensitive biological probe is connected to the surface of a functional silicon plastid through electrostatic interaction force to obtain a nuclease probe functional silicon plastid, and the nuclease probe functional silicon plastid is connected to the surface of an implant through photocuring hydrogel. According to the system provided by the invention, the detection is realized, the delivery of the medicine is also realized, and the release of the medicine can also be realized when the occurrence of infection around the prosthesis is judged, so that the intervention treatment of the medicine is carried out.

A reverse bolted greater trochanter periprosthetic plate configured to be mounted to a femur of a patient includes a central portion with an inner surface configured to face and / or contact a femoral surface of the femur; a plurality of leg portions extending from the central portion forming a claw configured to grasp a portion of the femur; and a bolt receptor portion extending from the central portion configured for receiving a bolt for securing the plate to the femur during a reverse bolted greater trochanter periprosthetic procedure.

A targeting system is disclosed. In use, the targeting system is configured to target (e.g., aim, locate, etc.) a fastener opening in a bone plate, and more particularly, a variable angle fastener opening formed in a perimeter of a periprosthetic bone plate. In one embodiment, the targeting system includes an alignment guide that includes a plurality of combination slots for targeting a plurality of openings formed in a periprosthetic bone plate. Additionally, the targeting system includes a plug that is configured to be positioned within a combination slot formed in the alignment guide. In use, positioning the plug into the combination slot formed in the alignment guide transforms the combination slot into a generally circular hole or opening having a predetermined trajectory that is aligned with one of the variable angle openings formed in the perimeter of the periprosthetic bone plate, thereby defining a trajectory from the alignment guide to the variable angle opening.

Provided herein is a computer-implemented method including obtaining values for non-modifiable risk factors, each defining an immutable patient characteristic determined to impact a likelihood that a complication results from an arthroplasty procedure. The system obtains first candidate values for modifiable risk factors of the patient defining a mutable characteristic of the patient or the arthroplasty procedure. The first candidate values are determined to minimize the likelihood that the complication results from the arthroplasty procedure. The system obtains second candidate values for the modifiable risk factors of the patient determined to maximize the likelihood that the complication results from the arthroplasty procedure. The system determines a personalized risk interval that represents a range of modifiable risk for the patient with respect to the arthroplasty procedure including determining (i) a lower bound and (ii) an upper bound for the personalized risk interval; and providing an output indicative of the risk interval.

Prosthetic periprosthetic bone fixation plates are disclosed, including, for example, prosthetic periprosthetic proximal femoral plates, prosthetic periprosthetic distal femoral plates, prosthetic periprosthetic humeral plates, prosthetic periprosthetic ring plates, and prosthetic periprosthetic trochanteric plates. In use, the prosthetic periprosthetic bone fixation plates are arranged and configured for use in periprosthetic bone fractures. That is, the prosthetic periprosthetic plates include one or more features to facilitate positioning and fixation of the bone fixation plate onto a patient's bone that previously received a surgically implanted orthopedic device or implant, such as, for example, an intramedullary nail, a hip prosthesis, a knee prosthesis, etc. In use, the one or more features are designed and configured to facilitate avoidance of the previously surgically implanted orthopedic device or implant. Additionally, the prosthetic periprosthetic bone fixation plates are arranged and configured to facilitate longer working length plate placement as compared to existing bone fixation plates (e.g., plate placement from, for example, the femoral condyle to the greater trochanter).

Apparatus and methods for preventing intraoperative periprosthetic femoral fracture in total hip arthroplasty (THA), by determining the implant position and femur bone condition changes during the THA by sensing changes in real time. The apparatus operates with a broach or stem, which is inserted into the femur; an auto-impactor; and a diversity of sensors on the interface adapter between the auto-impactor and the broach / stem. The apparatus and methods indicate the quality of implant insertion and enable early detection and warning of approaching the propensity to the intraoperative periprosthetic femoral fracture point by using quantifiable sensor data and trends and feeding real-time information into a decision support algorithm.

To provide a technical object identification system capable of easily identifying a patient who belongs to a completed dental technical object, a technical object identification method, and a program.SOLUTION: A technical object identification system 100 includes: a reference shape data acquisition unit 101 that acquires reference shape data that is STL data associated with technical instructions; an identification target technical object shape data acquisition unit 103 that acquires identification target technical object shape data; and a similarity determination unit 105 that compares a first feature amount based on the reference shape data and a second feature amount based on the identification target technical object shape data and determines similarity between the first feature amount and the second feature amount.SELECTED DRAWING: Figure 2

A modular orthopedic implant system configured to interconnect fracture fixation implants with arthroplasty components across multiple anatomic sites. The system incorporates a clothespin-style tapered male stem and a fluted female receiver, forming a secure, fatigue-resistant mechanical interface. This docking feature enables modular coupling between trauma implants such as intramedullary nails and joint replacement constructs including total hip stems, total knee femoral components, total shoulder stems, reverse shoulder humeral components, and ankle arthroplasty tibial components. The modular configuration allows adaptability across anatomical regions, facilitating revision, limb salvage, and periprosthetic fracture stabilization.

This invention provides a gradient silicon nitride ceramic femoral head prosthesis and its preparation method, relating to the technical fields of clinical medicine and biomaterials. The femoral head prosthesis is prepared from 88-94 parts of silicon nitride powder, 4-12 parts of sintering aid, 5-20 parts of tungsten carbide titanium, and 0-30 parts of pore-forming agent, wherein the pore-forming agent cannot be 0 parts. The gradient silicon nitride ceramic femoral head prosthesis of this invention retains the advantages of silicon nitride ceramics—low wear, low friction, high strength, high fracture toughness, and good chemical stability—at the interface between the femoral head prosthesis and the liner, while reducing wear on the titanium alloy femoral stem cone caused by the large hardness difference between the femoral head prosthesis and the liner. This reduces the incidence of organ toxicity, periprosthetic osteolysis, and aseptic loosening caused by metal wear debris, improves the survival rate of the femoral head prosthesis and the femoral stem cone, reduces the revision rate of replacement surgery, and saves patients' treatment costs.

This invention discloses a system and method for predicting the risk of periprosthetic infection after knee arthroplasty, belonging to the field of medical data analysis and processing technology. The system includes: an image acquisition interference detection module, an initial infection area determination module, an infection risk area correction module, and a risk prediction result output module. This invention quantitatively determines the interference of metal artifacts in image acquisition by combining relevant image parameters, ensuring the authenticity and reliability of the input images. Based on this, the initial infection area determination module initially identifies the infection risk area around the prosthesis, and the infection risk area correction module further corrects the initially determined infection area, outputting a more accurate corrected infection risk area. Finally, the risk prediction result output module outputs the final infection risk prediction result based on the corrected dataset. Through the synergistic effect of the above modules, the accuracy of periprosthetic infection risk prediction after knee arthroplasty is significantly improved.

The invention relates to the field of biological medicine, in particular to application of catalpol in preparation of a periprosthetic osteolysis inhibitor, which is helpful for inhibiting aseptic loosening of a prosthesis, can remarkably reduce the occurrence rate of joint replacement postoperative complications and realizes more effective clinical intervention, thereby accelerating rehabilitation of a patient and improving the daily life quality of the patient.

Medical instrumentation for simulation purposes in hip endoprosthetics, characterized by a simulation body (66) that can be tilted about a tilting axis (60) in a spatial reference system, a sensor unit (34) with which the magnitude and orientation of a tilting angle can be detected when the simulation body (66) is tilted, a data processing device (26) and a guidance unit (30), wherein the data processing device (26) is designed and programmed to simulate an inclination of a human pelvis (10) in a body reference system in which the pelvic inlet plane (B) of the pelvis (10) is inclined relative to a frontal plane (F) of the body by the tilting angle, and wherein the data processing device (26) outputs implantation information to the user at the guidance unit (30) that depends on the tilting angle.

The invention relates to the field of pharmacy, in particular to application of luteolin in preparation of a medicine for treating periprosthetic osteolysis. Experiments show that luteolin has an obvious inhibition effect on osteolysis induced by titanium particles by enhancing expression of FOXO3A, reducing oxidative stress of MC3T3-E1 cells, recovering osteogenesis functions of BMSCs and relieving osteolysis and bone loss induced by the titanium particles, and the luteolin can be used for preparing a medicine for treating osteolysis induced by the titanium particles. The method can be used as a new means for medicine intervention of osteolysis around the prosthesis after artificial prosthesis replacement.

Functional patient-specific acetabular component alignment is important in total hip arthroplasty. A method for acetabular component alignment by calculating pelvic tilt from an anteroposterior radiograph of the pelvis of a patient may be replicated intraoperatively for patient-specific alignment. A system for automated generation of the pelvic tilt from an anteroposterior radiograph presented improves the efficacy and accuracy of total hip arthroplasty.

The application provides a knee joint prosthesis periprosthetic fracture fixation device and an assembling method. The knee joint prosthesis comprises femoral condyles, a tibial plateau and a tibial pad. The femoral condyles comprise an anterior condyle, two posterior condyles and an intercondylar fossa. The fixation device is installed at the intercondylar fossa. The fixation device comprises an intramedullary fixation needle and a connecting fixation block. The connecting fixation block is installed in the intercondylar fossa. The connecting fixation block is connected with the force applying end of the intramedullary fixation needle. The connecting fixation block comprises a main body. The main body has a top surface facing the tibial pad and a bottom surface opposite to the top surface. The bottom surface extends in a direction away from the top surface to form a protruding part. A through hole penetrating through the main body is formed in the protruding part. The through hole is used for accommodating and fixing the force applying end of the intramedullary fixation needle. The whole connecting fixation block is embeddedly installed in the intercondylar fossa. The original intercondylar fossa space of the PS type prosthesis is fully utilized to establish a precise channel of the intramedullary fixation needle. The periprosthetic fracture is fixed through structural cooperation.

The present invention relates to a medical bone (10) plate for the treatment of fractures of the distal femur (2) with metaphyseal comminution, periprosthetic fractures, and / or interprosthetic fractures, the bone plate (10) being non-custom fit and non-planar, the bone plate (10) being twisted and having a proximal portion (12), a distal portion (16) and an intermediate portion (14) connecting the proximal portion (12) with the distal portion (16), wherein: a. the distal portion (16) is configured to fit to the distal medial femoral condyle (2a); b. the proximal portion (12) is configured to be aligned with the distal ventral section of the femoral shaft (2b).