482 results about "Cartilage" patented technology

Embodiments of the present invention relate generally to implant placement into bone. More specifically, embodiments of the invention relate to implant placement across the sacroiliac joint. Placement can be facilitated using various CT imaging views that allow the implants to be placed in bone associated with articular cartilage.

The invention relates to the technical field of medical informatics, in particular to a knee osteoarthritis traditional Chinese medicine treatment scheme optimization method based on big data analysis, and the method comprises the following steps: based on knee joint load distribution data, collecting knee joint shear stress data, monitoring cartilage stress gradient data, and calculating a stress peak value in a gait cycle; and obtaining a knee joint biomechanical load balance value. According to the method, by combining shear stress, cartilage stress gradient and gait cycle stress peak value calculation, individual biomechanical characteristics are accurately described, patellar tendon stretching and quadriceps femoris tendon displacement data are analyzed, the instantaneous elastic modulus is recognized, tendon adaptability adjustment measurement precision is improved, soft tissue elastic change is reflected, and by means of individualized stress characteristic data, the stability of the muscle tendon is improved. Abnormal data are eliminated, illness state analysis is optimized, the curative effect evaluation accuracy is improved, the rehabilitation training intensity is dynamically optimized according to the curative effect offset degree, the therapeutic scheme is more adaptive, and the curative effect predictability and the personalized level are improved.

The invention provides a method and system for reconstructing a cartilage surface and electronic equipment, and the method comprises the steps: obtaining an outer contour model of a bone cortex and a mark point set of the cartilage surface, and converting the outer contour model of the bone cortex and the mark point set of the cartilage surface into a preset image coordinate system; obtaining a projection point of each mark point in the mark point set on the cartilage surface on the outer contour of the bone cortex, and determining a coverage area of the projection points; performing elastic stretching on the coverage area of the projection point, and further simulating the wear degree of the cartilage surface to obtain a reconstructed cartilage surface; the problem that muscle or ligament abrasion is caused due to the fact that the influence of cartilage is not brought into prosthesis planning in an existing joint replacement operation is solved, practical and effective guidance can be provided during prosthesis planning and adjusting, prosthesis planning and adjusting are better facilitated, and the prosthesis planning and adjusting efficiency is improved. The intelligent degree, usability and reliability of prosthesis planning in joint replacement are improved to a great extent.

The invention discloses a composition for promoting cartilage repair and maintaining joint health as well as a preparation process and application thereof, and relates to the technical field of functional foods. The composition is prepared from the following components in parts by weight: 21.1 to 90 parts of a multi-protein complex, 0.1 to 3 parts of cherry powder, 0.01 to 2 parts of N-acetylglucosamine, 0.01 to 2 parts of radix puerariae powder, 0.1 to 1.5 parts of a calcium compound and 0.01 to 0.2 part of rhizoma curcumae longae, the multi-protein compound is prepared from 0.1 to 10 parts of ray collagen peptide, 1 to 30 parts of bone collagen peptide powder and 20 to 50 parts of fish collagen peptide. The composition provided by the invention can promote cartilage repair, achieves the purpose of daily maintenance of joint health, and has a good application prospect.

An ankle joint replacement prosthesis comprises a tibia prosthesis assembly and a talus prosthesis, the tibia prosthesis assembly comprises a tibia prosthesis body and a cushion block, the tibia prosthesis body and the cushion block are in an arc shape with the middle bent upwards on the sagittal plane, the cushion block is arranged at the bottom of the tibia prosthesis body in a sleeving mode, and the surface of the upper portion of the tibia prosthesis body is a tibia joint face. The surface of the lower portion of the cushion block is a first articular surface, the surface of the upper portion of the talus prosthesis is a second articular surface, the second articular surface is in an arc shape with the middle bent upwards on a sagittal plane, the surface of the lower portion of the talus prosthesis is a talus joint surface, and the first articular surface is matched with the second articular surface. When the prosthesis is implanted, only the articular cartilage and the subchondral bone need to be treated at the far end of the tibia, so that the bone at the far end of the tibia is reserved to the maximum extent, the anatomical integrity of the bone is guaranteed, the stability of the prosthesis is enhanced, the service life is prolonged, and the clinical operation effect is improved.

The utility model relates to the technical field of tissue repair, and discloses a tissue repair implant and a tissue repair set for repairing bones and / or cartilages. The tissue repair implant comprises an insertion body, the insertion body comprises a first end face and a second end face which are oppositely arranged in the insertion direction of the insertion body, the insertion body comprises at least one axial channel extending from the first end face to the second end face, and the axial channels are an autologous stem cell attachment migration channel and a new vessel growth space. In use, the insertion main body can be implanted into the implantation hole, and autologous stem cells can migrate upwards to the first end face along the at least one axial channel, diffuse towards the periphery in the insertion main body in the axial channel and reach a cartilage layer; therefore, cartilage located on the first end face in the implantation hole is promoted to be regenerated, and the insertion body and original bone tissue around the implantation hole form a unified whole. Therefore, the tissue repair implant can form a stable and good implantation compatibility effect in the implantation hole.

The invention discloses a Zhejiang anoectochilus roxburghii polysaccharide and application thereof in preparation of cartilage injury repair medicine.The Zhejiang anoectochilus roxburghii polysaccharide is characterized in that a crude polysaccharide AZJP is extracted from the Zhejiang anoectochilus roxburghii polysaccharide through a hot water extraction method, an anion exchange column DEAE-celluse-52 and a gel permeation chromatographic column Sephadex G-200 are used for separating the AZJP, and the Zhejiang anoectochilus roxburghii homogeneous polysaccharides AZJP-1a, AZJP-2a, AZJP-2b and AZJP-2c are obtained; measuring UV (ultraviolet), IR (infrared), molecular weight, monosaccharide composition, methylated sugar residues, NMR (nuclear magnetic resonance) signals, triple helix structures, SEM (scanning electron microscope) and AFM (atomic force microscopy) surface microstructures and cartilage repair activity; the four homogeneous polysaccharides have remarkable cartilage repair activity on transgenic zebrafish, are superior to a positive drug alendronate sodium, and have application prospects in development of drugs for treating osteoarticular cartilage injuries.

The invention provides a preparation method of a gradient bionic rotator cuff repair stent, the stent prepared by the method and application. The method comprises the following steps that 1, a gradient fiber structure is designed through conventional 3D modeling software; step 2, adding the raw materials into the barrel material, and printing a tendon scaffold by adopting a near-field direct-writing melting technology; 3, raw materials in the barrel material are replaced, and the cartilage scaffold is printed through the near-field direct-writing melting technology; optionally, replacing the raw materials in the barrel material, and printing the mineralized cartilage scaffold by adopting a near-field direct-writing melting technology; and 4, replacing the raw materials in the barrel material, and printing the bone scaffold by adopting a near-field direct-writing fusion technology. The stent disclosed by the invention has a structural gradient and a component gradient, is matched with natural bone tissues, and can better promote the repair of the bone tissues.

The poultry claw and tarsal articular cartilage removing device comprises a first connecting block, a second connecting block, a scraping block, a limiting block and an adjusting rod, the scraping block is arranged at the front end of the first connecting block, and the rear end of the first connecting block is connected with the upper end of the second connecting block; the adjusting rod is arranged below the first connecting block and is adjustably connected with the first connecting block or the second connecting block, and the limiting block is arranged at the front end of the adjusting rod. According to the cartilage deboning device, the distance between the limiting block and the scraping block can be adjusted through the adjusting rod, so that the cartilage deboning device can adapt to poultry claws of different specifications, the cartilage deboning efficiency can be effectively improved, and food material waste caused by skin and meat involved by articular cartilage in the deboning process is avoided.

The invention relates to the technical field of online detection and analysis, and discloses a bone joint synovial fluid detection and analysis system based on microfluidics, which specifically comprises the following steps: acquiring synovial fluid rheological data and synovial fluid molecular activity data in a bone joint movement process and cartilage surface morphological data in a joint buckling process through a biosensor; constructing a synovial fluid dynamic anomaly analysis model, and performing synovial fluid function anomaly analysis through the synovial fluid rheological data and the molecular activity data; a cartilage stress anomaly analysis model is constructed, and cartilage stress anomaly analysis is carried out through cartilage surface morphological change data; obtaining a synovial fluid function abnormality analysis result and a cartilage stress abnormality analysis result to carry out bone joint function adaptability analysis; and acquiring a bone joint function adaptability analysis result and carrying out synovial fluid function abnormality analysis early warning. The problem that in the prior art, due to the fact that the bionic degree of a detection strategy is insufficient and bone joint dynamic parameters are deficient, the association degree of a static synovial fluid detection result and the actual joint rehabilitation condition of a patient is poor is solved.

The invention discloses a muscle-bone regeneration sustained-release preparation for targeting knee joint cartilage and a preparation process thereof, the preparation is composed of a cartilage targeting peptide modified PLGA-hyaluronic acid composite nanoparticle sustained-release carrier, an active regeneration component, a biocompatible matrix and an anti-inflammatory component, nanoparticles are prepared by a multiple emulsion solvent evaporation method, and targeting peptide is modified; the composite concentrated growth factors, stem cells and traditional Chinese medicine extracts have the functions of targeted enrichment, long-acting slow release, anti-inflammation and cartilage regeneration promotion, and can be used for knee joint cartilage defect repair.

The invention relates to the technical field of knee joint cartilage, in particular to a knee joint cartilage repair fixing support which comprises a first fixing plate, a second fixing plate is mounted at the bottom end of the first fixing plate, connecting arc plates are fixedly connected to one end of the first fixing plate and one end of the second fixing plate, and an elastic band is mounted at one end of each connecting arc plate. The connecting arc plate and the elastic band form an annular structure capable of being arranged on the leg in a sleeving mode, an inserting groove is formed in the end, close to the second fixing plate, of the first fixing plate, a telescopic plate is fixedly installed at the end, close to the first fixing plate, of the second fixing plate, and the telescopic plate is inserted into the inserting groove and fixed through a positioning assembly. Through the design, the telescopic plate moves in the inserting groove, so that the distance between the first fixing plate and the second fixing plate is increased or reduced, the device can be suitable for different crowds to use, meanwhile, the positioning assembly is used for fixing, stability is high, the fixing mode is easy to operate, and the movement strength of a patient can be well reduced.

The invention provides a mineralized collagen cartilage repair scaffold and a preparation method and application thereof, and relates to the technical field of biomedical materials.The preparation method comprises the steps that a collagen solution subjected to mineralization treatment is injected into a mold, and a mineralized collagen layer is obtained through deep freezing and primary freeze drying; taking the mineralized collagen layer as a bottom layer, injecting a collagen solution which is not mineralized, and performing deep freezing and first freeze drying to obtain a freeze-dried scaffold; and carrying out crosslinking and secondary freeze drying on the freeze-dried scaffold, and compressing to obtain the mineralized collagen cartilage repair scaffold. A necessary bioactive interface, a continuous interpenetrating structure of a collagenous fiber network and cross-linking treatment are provided for osseointegration, and interlayer separation is avoided; bidirectional regeneration of osteochondral bone is realized, and complexity and risk of clinical application are reduced; in a wet state, good tailorability and enough stiffness are achieved, and meanwhile stable mechanical support is provided; the technical problem that in the prior art, a stent material is insufficient in systematicness of biosecurity of multi-scale structure bionics and interface bonding agents is solved.

This invention relates to the treatment of osteoarthritic pain, or pain associated with osteoarthritis, and particularly for LINK_TSG6 polypeptide for use in the treatment of osteoarthritic pain. Osteoarthritis is caused by the deterioration of cartilage in joints and is characterised by pain and a loss of mobility in the affected joints. Osteoarthritic pain results from multiple factors including bone marrow lesions, sub-articular bone attrition, synovitis, effusion and innervation of usually insensitive tissues. LINK_TSG6 is a short recombinant peptide comprising the LINK module of human TSG-6.

An instrument for use in cartilage removal comprises an elongate body having a first end and a longitudinal axis having a longitudinal direction. A cartilage removal portion is coupled to the elongate body at the first end. The cartilage removal portion includes a plurality of serrated blades substantially perpendicular to the longitudinal axis and adapted for removing material while moving in the longitudinal direction. Each serrated blade has a centroid located along the longitudinal axis.

The invention relates to the technical field of biomedical materials, in particular to multi-material 3D printing bionic gradient soft-hard integrated hydrogel as well as a preparation method and application thereof. Based on a copolymerization system of high-strength supramolecular N-acryloylglycinamide and vinyl phosphoric acid, an NAGA aqueous solution and an NAGA-VPA aqueous solution are printed into hydrogel of a gradient structure by adopting a DLP multi-material printing technology, then the hydrogel is sequentially soaked in a calcium-phosphorus mixed aqueous solution (Ca / P = 1.67), ammonia water, a calcium chloride aqueous solution and deionized water, and the hydrogel is prepared through a hydrothermal method. Therefore, in-situ gradient deposition and curing of hydroxyapatite (HAP) are realized. The multi-material 3D printing bionic gradient soft-hard integrated hydrogel prepared by the method has a continuous biochemical-mechanical gradient, a surface layer low-modulus area is matched with cartilage performance, a deep layer high-mineralization area is integrated with bone tissue, the HAP crystallinity of a transition area is in spatial dependence distribution, and the hydrogel is suitable for osteochondral defect repair and manufacturing of bionic joint prostheses.

Whole blood is mixed with one or more coagulators to produce coagulated blood which is then introduced into a site of bone or joint damage or disease and allowed to coagulate at the site. The aim is to promote healing or amelioration of a disease, disorder or lesion at the site, such as healing and regeneration-6623 of damaged bone, damaged joint, cartilage lesion, and the like.

The invention relates to the technical field of medical data processing, and discloses a hip joint bone cartilage forming operation planning method, system and equipment based on a reverse motion envelope surface and a medium, and aims to accurately identify a bone impact area through all-attitude three-dimensional collision detection and remarkably reduce missed diagnosis and excessive resection risks; the device adapts to multiple pelvis postures, and limitation of a single posture is avoided; an inverse motion enveloping strategy is adopted, so that the operation efficiency and precision are improved, and the submillimeter resolution is realized; a multi-attitude and time dimension collision detection process is simplified, a potential conflict area is quickly obtained through union set operation, and digital operation planning is greatly facilitated. In addition, a doctor can be assisted in obtaining a three-dimensional visual'to-be-cut-off area 'before an operation, and the operation time is shortened; human experience errors are reduced, and the postoperative joint motion range is improved; the hip joint protection surgery is promoted to be converted from a two-dimensional scheme to a'three-dimensional + time 'multi-dimensional refined planning, and the method has important significance in reducing surgical wounds and improving postoperative functional recovery.

The invention discloses a cartilage calcification layer imaging method and device, equipment and a medium, and relates to the technical field of image processing, and the method comprises the steps: obtaining a to-be-imaged knee joint specimen, carrying out the magnetic resonance scanning of the to-be-imaged knee joint specimen, and obtaining a plurality of to-be-processed images; performing double-echo subtraction processing on the first to-be-processed image and the second to-be-processed image to obtain a target image which contains a cartilage calcification layer represented in a high-signal strip form and meets a preset high-resolution condition, and determining position information and form information of the cartilage calcification layer in the target image; and performing single-index fitting processing on all the to-be-processed images to obtain a target quantitative map, processing the target quantitative map based on the position information and the form information to obtain quantitative information of a cartilage calcification layer, and obtaining a target high-resolution image of the to-be-imaged knee joint specimen based on the quantitative information and the target image. And a high-definition image for clearly displaying the fine structure of the calcified cartilage layer is obtained.

The invention belongs to the field of pet food processing, and relates to a premix for improving joint health of pets and a preparation method thereof. The premix is added with the following natural components: rhizoma polygonati, rhizoma drynariae, eucommia ulmoides, ligusticum wallichii, liquorice, turmeric, poria cocos and Chinese yam. The whole formula has the effects of tonifying liver and kidney to consolidate the root, promoting blood circulation to remove meridian obstruction to treat symptoms, tonifying spleen to remove dampness to assist transportation and transformation, tonifying spleen to prevent dampness stagnation, promoting diuresis to prevent positive qi injury, treating both symptoms and root causes, combining dredging and tonifying, and directly reaching the effects on joints. The premix can tonify cartilage, strengthen ligament, relieve pain, supplement synovial fluid, effectively improve the arthritis health of pets and improve the life quality of pets.

The invention relates to a device and a method for detecting the retention performance of a liquid-phase solute of articular cartilage. The method comprises the following steps: adhering and fixing a treated cartilage on a perforated rubber plug; the cartilage pasted with the rubber plug is placed in a retention device with a perforated plate at the bottom, and water is added till the cartilage completely exceeds an overflow opening; the retention pressing rod provided with the rubber plug is pressed into the retention device, and whether liquid leakage exists or not is detected in advance; discharging the water, adding a solution required by a retention experiment, and pressing the retention pressure rod again; the retention device is arranged in the cylindrical base, and the screws on the two sides are fastened; the base of the device is fixed on a lower disc of a testing machine; a retention compression bar of the device is fixed on an upper disc of a testing machine; and setting expected pressure and time, starting to load experimental pressure, and then starting a cartilage retention experiment. And after the retention experiment is finished, observing the retention state of the fluorescent solute molecules by using a slicing machine and a laser confocal microscope. The cartilage liquid phase solute retention performance is effectively detected, the problem that sealing performance is difficult in a retention experiment is solved, a cartilage mass transfer research method is expanded, and the detection precision and stability are improved. The method is expected to be popularized to become a standard test technology of cartilage retention performance, and plays a positive role in promoting cartilage in-vitro experiments.

The application provides a composite gel product which is designed according to the main components of articular cartilage based on the bionics principle and is made of biological cellulose (BC), polyvinyl alcohol (PVA), an anionic surfactant and chitosan, has mechanical properties, friction characteristics close to articular cartilage and good biocompatibility and degradability and can be used for preparing a cartilage joint injury repair material.

A personalized joint skeletal and cartilage morphometry system is provided that uses artificial intelligence. [Solution] The personalized joint skeleton and cartilage morphometry system includes a database 11, an image acquisition module 12, an image analysis module 13, a neural network model 14, a model construction module 15 and a calculation module 16. The database stores a dataset. The image acquisition module acquires a plurality of skeleton images of a subject. The image analysis module processes the skeleton images by a statistical shape model and principal component analysis to generate a 3D model of the skeleton and cartilage. The neural network model generates and outputs skeleton motion parameters. The model construction module generates the personalized joint skeleton and cartilage model. The calculation module simulates the relative positions between the 3D models of the skeleton and cartilage during motion and calculates the cartilage shape and cartilage wear value.

A method includes making an incision (e.g., postauricular incision) of an ear of a recipient to reveal cartilage in a pinna of the ear, forming a cutout in the cartilage in the pinna, and positioning a diaphragm of a microphone device in the cutout to implant the microphone device in the pinna.

The invention provides a controllable degradation magnesium-based bionic biphasic stent as well as a preparation method and application thereof. The stent comprises a porous magnesium stent, hydrogel and a ceramic coating, the porous magnesium scaffold comprises a cartilage phase scaffold and a subchondral bone phase scaffold which are arranged from top to bottom; hydrogel is arranged on pores and the outer surface of the cartilage phase scaffold, and a ceramic coating is arranged on the surface of the subchondral bone phase scaffold. From the bionic angle, the three-dimensional communicated porous magnesium stent with gradient porosity is designed by simulating the structure, mechanics and other characteristics of joint tissues (upper cartilage and lower subchondral bone); meanwhile, according to the characteristics of joint tissue components, biological properties and the like, hydrogel (an upper cartilage phase) is filled in the stent, and a bioactive ceramic coating (a lower subchondral bone phase) is prepared on the surface of the stent, so that the degradation rate of the biphasic magnesium stent is regulated and controlled, and the cytotoxicity is reduced; meanwhile, the biocompatibility and the biological activity are improved, and endogenous cartilage-subchondral bone integrated repair is realized.

The invention discloses a multifunctional bone peptide compound and application thereof in prevention and treatment of osteoporotic osteoarthritis, and relates to the technical field of bone peptides. The multifunctional bone peptide compound is prepared from the following raw materials: giant salamander bone meal, bovine bone articular cartilage powder, bovine bone meal, sturgeon bone meal, oyster bone meal, deer-horn glue powder, calcium chloride and fructo-oligosaccharide. According to the multifunctional bone peptide compound disclosed by the invention, the composite aggregate is subjected to enzymolysis step by step by using the compound enzyme, the bone peptide and calcium ions are compounded through a chelation reaction, the absorbability of calcium is improved, one part of the bone peptide in the composite bone peptide has a function of promoting osteoblast activity, and the other part of the bone peptide possibly has a function of inhibiting overactivity of osteoclasts; part of the bone peptide has an anti-inflammatory effect, can regulate bone metabolism, repair articular cartilage and relieve inflammatory response, and can improve the effect of the bone peptide product in the aspects of preventing and treating osteoporosis, osteoarthritis and other diseases.

The invention discloses a cartilage repair hydrogel material and a preparation method thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: adding a vitamin E water-soluble derivative D-alpha-tocopherol polyethylene glycol 1000 succinate, T-ZIF-8 modified by 2, 4-toluene diisocyanate and Mg-MOF modified by SIKVAV peptide into a mixed solution obtained by compounding silk fibroin peptide, oxidized chondroitin sulfate and 3-aminophenylboronic acid, and carrying out crosslinking under ultraviolet light, so as to obtain the cartilage repair hydrogel material. The hydrogel material prepared by the method has a three-dimensional complex cross-linked structure and is high in mechanical property and stability; through the synergistic effect of the components, an adhesion group and a hydrophilic group are created for the surface of the hydrogel material, the binding opportunity of bone cells and the surface of the hydrogel material is increased, adhesion and proliferation of the bone cells are promoted, rejection reaction of tissues to metal materials is reduced, inflammatory reaction is reduced, and collagen secretion and cartilage regeneration are promoted.

Methods, systems, and devices for treating osteochondral defects (OCDs) are disclosed. The disclosed methods and systems include collecting joint surface data using image-free methods, generating a three-dimensional (3D) healthy bone model based on the joint surface data and a database of healthy bone anatomies, defining the OCD boundary on the joint, generating a 3D implant model based on the 3D healthy bone model and the OCD boundary, manufacturing an implant based on the 3D implant model, generating an implantation plan, the resected cavity on the joint. The implant includes a 3D-printed titanium alloy substrate having a first and second porous layer separated by a nonporous layer. A polymer material is over-molded onto the second porous layer and treated to exhibit properties that mimic cartilage, while the first porous layer allows the implant to fuse to patient bone.

A drill-less method of stabilizing a sacroiliac joint using a multimodal abrading device to create a rich environment for bony fusion. The unique decortication instrument includes an integral slap hammer assembly joined with a rasp-box osteotome tooling head to simultaneously remove cartilage from the joint while preparing the sacrum and ilium down to bleeding bone. Subsequent to joint preparation, an implant with a large bone graft window may be implanted into the prepared SI joint through a specially designed access cannula.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.