375 results about "Cartilage" patented technology

The invention discloses a composition for promoting cartilage repair and maintaining joint health as well as a preparation process and application thereof, and relates to the technical field of functional foods. The composition is prepared from the following components in parts by weight: 21.1 to 90 parts of a multi-protein complex, 0.1 to 3 parts of cherry powder, 0.01 to 2 parts of N-acetylglucosamine, 0.01 to 2 parts of radix puerariae powder, 0.1 to 1.5 parts of a calcium compound and 0.01 to 0.2 part of rhizoma curcumae longae, the multi-protein compound is prepared from 0.1 to 10 parts of ray collagen peptide, 1 to 30 parts of bone collagen peptide powder and 20 to 50 parts of fish collagen peptide. The composition provided by the invention can promote cartilage repair, achieves the purpose of daily maintenance of joint health, and has a good application prospect.

An ankle joint replacement prosthesis comprises a tibia prosthesis assembly and a talus prosthesis, the tibia prosthesis assembly comprises a tibia prosthesis body and a cushion block, the tibia prosthesis body and the cushion block are in an arc shape with the middle bent upwards on the sagittal plane, the cushion block is arranged at the bottom of the tibia prosthesis body in a sleeving mode, and the surface of the upper portion of the tibia prosthesis body is a tibia joint face. The surface of the lower portion of the cushion block is a first articular surface, the surface of the upper portion of the talus prosthesis is a second articular surface, the second articular surface is in an arc shape with the middle bent upwards on a sagittal plane, the surface of the lower portion of the talus prosthesis is a talus joint surface, and the first articular surface is matched with the second articular surface. When the prosthesis is implanted, only the articular cartilage and the subchondral bone need to be treated at the far end of the tibia, so that the bone at the far end of the tibia is reserved to the maximum extent, the anatomical integrity of the bone is guaranteed, the stability of the prosthesis is enhanced, the service life is prolonged, and the clinical operation effect is improved.

The invention relates to the technical field of online detection and analysis, and discloses a bone joint synovial fluid detection and analysis system based on microfluidics, which specifically comprises the following steps: acquiring synovial fluid rheological data and synovial fluid molecular activity data in a bone joint movement process and cartilage surface morphological data in a joint buckling process through a biosensor; constructing a synovial fluid dynamic anomaly analysis model, and performing synovial fluid function anomaly analysis through the synovial fluid rheological data and the molecular activity data; a cartilage stress anomaly analysis model is constructed, and cartilage stress anomaly analysis is carried out through cartilage surface morphological change data; obtaining a synovial fluid function abnormality analysis result and a cartilage stress abnormality analysis result to carry out bone joint function adaptability analysis; and acquiring a bone joint function adaptability analysis result and carrying out synovial fluid function abnormality analysis early warning. The problem that in the prior art, due to the fact that the bionic degree of a detection strategy is insufficient and bone joint dynamic parameters are deficient, the association degree of a static synovial fluid detection result and the actual joint rehabilitation condition of a patient is poor is solved.

The invention discloses a muscle-bone regeneration sustained-release preparation for targeting knee joint cartilage and a preparation process thereof, the preparation is composed of a cartilage targeting peptide modified PLGA-hyaluronic acid composite nanoparticle sustained-release carrier, an active regeneration component, a biocompatible matrix and an anti-inflammatory component, nanoparticles are prepared by a multiple emulsion solvent evaporation method, and targeting peptide is modified; the composite concentrated growth factors, stem cells and traditional Chinese medicine extracts have the functions of targeted enrichment, long-acting slow release, anti-inflammation and cartilage regeneration promotion, and can be used for knee joint cartilage defect repair.

The invention provides a mineralized collagen cartilage repair scaffold and a preparation method and application thereof, and relates to the technical field of biomedical materials.The preparation method comprises the steps that a collagen solution subjected to mineralization treatment is injected into a mold, and a mineralized collagen layer is obtained through deep freezing and primary freeze drying; taking the mineralized collagen layer as a bottom layer, injecting a collagen solution which is not mineralized, and performing deep freezing and first freeze drying to obtain a freeze-dried scaffold; and carrying out crosslinking and secondary freeze drying on the freeze-dried scaffold, and compressing to obtain the mineralized collagen cartilage repair scaffold. A necessary bioactive interface, a continuous interpenetrating structure of a collagenous fiber network and cross-linking treatment are provided for osseointegration, and interlayer separation is avoided; bidirectional regeneration of osteochondral bone is realized, and complexity and risk of clinical application are reduced; in a wet state, good tailorability and enough stiffness are achieved, and meanwhile stable mechanical support is provided; the technical problem that in the prior art, a stent material is insufficient in systematicness of biosecurity of multi-scale structure bionics and interface bonding agents is solved.

The invention relates to the technical field of biomedical materials, in particular to multi-material 3D printing bionic gradient soft-hard integrated hydrogel as well as a preparation method and application thereof. Based on a copolymerization system of high-strength supramolecular N-acryloylglycinamide and vinyl phosphoric acid, an NAGA aqueous solution and an NAGA-VPA aqueous solution are printed into hydrogel of a gradient structure by adopting a DLP multi-material printing technology, then the hydrogel is sequentially soaked in a calcium-phosphorus mixed aqueous solution (Ca / P = 1.67), ammonia water, a calcium chloride aqueous solution and deionized water, and the hydrogel is prepared through a hydrothermal method. Therefore, in-situ gradient deposition and curing of hydroxyapatite (HAP) are realized. The multi-material 3D printing bionic gradient soft-hard integrated hydrogel prepared by the method has a continuous biochemical-mechanical gradient, a surface layer low-modulus area is matched with cartilage performance, a deep layer high-mineralization area is integrated with bone tissue, the HAP crystallinity of a transition area is in spatial dependence distribution, and the hydrogel is suitable for osteochondral defect repair and manufacturing of bionic joint prostheses.

The invention relates to the technical field of medical data processing, and discloses a hip joint bone cartilage forming operation planning method, system and equipment based on a reverse motion envelope surface and a medium, and aims to accurately identify a bone impact area through all-attitude three-dimensional collision detection and remarkably reduce missed diagnosis and excessive resection risks; the device adapts to multiple pelvis postures, and limitation of a single posture is avoided; an inverse motion enveloping strategy is adopted, so that the operation efficiency and precision are improved, and the submillimeter resolution is realized; a multi-attitude and time dimension collision detection process is simplified, a potential conflict area is quickly obtained through union set operation, and digital operation planning is greatly facilitated. In addition, a doctor can be assisted in obtaining a three-dimensional visual'to-be-cut-off area 'before an operation, and the operation time is shortened; human experience errors are reduced, and the postoperative joint motion range is improved; the hip joint protection surgery is promoted to be converted from a two-dimensional scheme to a'three-dimensional + time 'multi-dimensional refined planning, and the method has important significance in reducing surgical wounds and improving postoperative functional recovery.

The invention discloses a cartilage calcification layer imaging method and device, equipment and a medium, and relates to the technical field of image processing, and the method comprises the steps: obtaining a to-be-imaged knee joint specimen, carrying out the magnetic resonance scanning of the to-be-imaged knee joint specimen, and obtaining a plurality of to-be-processed images; performing double-echo subtraction processing on the first to-be-processed image and the second to-be-processed image to obtain a target image which contains a cartilage calcification layer represented in a high-signal strip form and meets a preset high-resolution condition, and determining position information and form information of the cartilage calcification layer in the target image; and performing single-index fitting processing on all the to-be-processed images to obtain a target quantitative map, processing the target quantitative map based on the position information and the form information to obtain quantitative information of a cartilage calcification layer, and obtaining a target high-resolution image of the to-be-imaged knee joint specimen based on the quantitative information and the target image. And a high-definition image for clearly displaying the fine structure of the calcified cartilage layer is obtained.

The invention belongs to the field of pet food processing, and relates to a premix for improving joint health of pets and a preparation method thereof. The premix is added with the following natural components: rhizoma polygonati, rhizoma drynariae, eucommia ulmoides, ligusticum wallichii, liquorice, turmeric, poria cocos and Chinese yam. The whole formula has the effects of tonifying liver and kidney to consolidate the root, promoting blood circulation to remove meridian obstruction to treat symptoms, tonifying spleen to remove dampness to assist transportation and transformation, tonifying spleen to prevent dampness stagnation, promoting diuresis to prevent positive qi injury, treating both symptoms and root causes, combining dredging and tonifying, and directly reaching the effects on joints. The premix can tonify cartilage, strengthen ligament, relieve pain, supplement synovial fluid, effectively improve the arthritis health of pets and improve the life quality of pets.

The application provides a composite gel product which is designed according to the main components of articular cartilage based on the bionics principle and is made of biological cellulose (BC), polyvinyl alcohol (PVA), an anionic surfactant and chitosan, has mechanical properties, friction characteristics close to articular cartilage and good biocompatibility and degradability and can be used for preparing a cartilage joint injury repair material.

A method includes making an incision (e.g., postauricular incision) of an ear of a recipient to reveal cartilage in a pinna of the ear, forming a cutout in the cartilage in the pinna, and positioning a diaphragm of a microphone device in the cutout to implant the microphone device in the pinna.

The invention provides a controllable degradation magnesium-based bionic biphasic stent as well as a preparation method and application thereof. The stent comprises a porous magnesium stent, hydrogel and a ceramic coating, the porous magnesium scaffold comprises a cartilage phase scaffold and a subchondral bone phase scaffold which are arranged from top to bottom; hydrogel is arranged on pores and the outer surface of the cartilage phase scaffold, and a ceramic coating is arranged on the surface of the subchondral bone phase scaffold. From the bionic angle, the three-dimensional communicated porous magnesium stent with gradient porosity is designed by simulating the structure, mechanics and other characteristics of joint tissues (upper cartilage and lower subchondral bone); meanwhile, according to the characteristics of joint tissue components, biological properties and the like, hydrogel (an upper cartilage phase) is filled in the stent, and a bioactive ceramic coating (a lower subchondral bone phase) is prepared on the surface of the stent, so that the degradation rate of the biphasic magnesium stent is regulated and controlled, and the cytotoxicity is reduced; meanwhile, the biocompatibility and the biological activity are improved, and endogenous cartilage-subchondral bone integrated repair is realized.

Methods, systems, and devices for treating osteochondral defects (OCDs) are disclosed. The disclosed methods and systems include collecting joint surface data using image-free methods, generating a three-dimensional (3D) healthy bone model based on the joint surface data and a database of healthy bone anatomies, defining the OCD boundary on the joint, generating a 3D implant model based on the 3D healthy bone model and the OCD boundary, manufacturing an implant based on the 3D implant model, generating an implantation plan, the resected cavity on the joint. The implant includes a 3D-printed titanium alloy substrate having a first and second porous layer separated by a nonporous layer. A polymer material is over-molded onto the second porous layer and treated to exhibit properties that mimic cartilage, while the first porous layer allows the implant to fuse to patient bone.

A drill-less method of stabilizing a sacroiliac joint using a multimodal abrading device to create a rich environment for bony fusion. The unique decortication instrument includes an integral slap hammer assembly joined with a rasp-box osteotome tooling head to simultaneously remove cartilage from the joint while preparing the sacrum and ilium down to bleeding bone. Subsequent to joint preparation, an implant with a large bone graft window may be implanted into the prepared SI joint through a specially designed access cannula.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

The invention relates to the technical field of image data processing, in particular to a knee joint MR image enhancement method and system. The method comprises the following steps: according to the gradient direction similarity of pixel points in a knee joint MR image between different scales and the difference between the amplitude value of the pixel points and the maximum amplitude value in the knee joint MR image, determining a noise map and carrying out separation to obtain a target knee joint MR image; according to the ratio of the area of a super-pixel block in the target knee joint MR image to the area of the minimum enclosing rectangle of the super-pixel block, the difference between the gray average value and the maximum gray value of the super-pixel block, and the gray average value difference between the super-pixel block and peripheral pixel points, a cartilage collagen fiber region is obtained; in the Laplace operator, the cartilage collagen fiber area and other areas in the target knee joint MR image are sharpened and enhanced by using different coefficients, the enhanced knee joint MR image is obtained, and the accuracy of knee joint MR image enhancement is effectively improved.

This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and / or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.

Devices and methods for treating joint degeneration (e.g., intervertebral disc degeneration) are provided. An example method may comprise: (1) advancing a tip of an introducer needle into a nucleus pulpous of an intervertebral disc; (2) with the tip of the introducer needle in the nucleus pulpous, maneuvering, out of the tip of the introducer needle, a tip of a flexible needle into a region of a cartilaginous endplate (CEP) of the intervertebral disc; and (3) delivering, from an aperture of the flexible needle, therapeutic to the region of the CEP.

The application discloses an ankle joint prosthesis, which comprises a tibia component, a pad and a talus component connected in sequence, and a plurality of bionic ligaments; the tibia component comprises a first intramedullary canal handle and a platform connected to the lower end of the first intramedullary canal handle; the pad comprises a pad body, and the upper surface of the pad body is provided with a cylindrical boss; the talus component comprises a second intramedullary canal handle and a connecting piece connected to the upper end of the second intramedullary canal handle; and the bionic ligaments are connected to the pad and the talus component respectively. The ankle joint prosthesis can completely replace the bone and cartilage of the ankle joint surface, thereby overcoming the problem that the cartilage surface cannot be repaired by an ankle arthroscopy surgery. The ankle joint prosthesis is used for replacing the original damaged ankle joint by using metal and polymer components, so that the discomfort symptom is relieved and the joint activity ability is reserved, and the ankle joint prosthesis is a full freedom ankle joint prosthesis which can completely reserve six activity modes of flexion, extension, inversion, eversion, internal rotation and external rotation.

The utility model belongs to the technical field of medical instruments, and particularly discloses a cartilage cortex cutting knife which comprises a knife head. The tool bit is detachably installed at the head end of the handle, and a protection frame is arranged at the head end of the handle to shield the tool bit. The handle is in an arc shape with two protruding sides and a concave middle, and the head end of the handle is an inclined plane tangent to the arc line of the front end of the handle. When cartilage cortex cutting is carried out, under the arc arrangement that the two sides of the handle are convex and the middle of the handle is concave, an operator holds the handle more stably, the tool bit is detachably arranged on the inclined plane tangent to the arc line at the front end of the handle, the operator can apply force better to cut cartilage cortex conveniently, and the tool bit can be detached and replaced conveniently; meanwhile, the protective frame is arranged at the head end of the handle to shield the cutter head, the protective frame can fully shield the cutter head when cartilage cortex is cut, and the cutter head is prevented from accidentally injuring an operator.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the femorotibial joint, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

A surgical cutting device (10) for cutting and removing cartilage from an affected area is disclosed. The surgical cutting device includes an elongated shaft (12) having a proximal portion (18) and a distal portion (20) connected between a proximal end (14) and a distal end (16). A central longitudinal axis extends through the elongated shaft. The proximal portion has a first diameter and the distal portion has a second diameter, the first diameter being greater than the second diameter. The cutting device further includes a cutting tip (22) at the distal end of the elongated shaft. The cutting tip extends at an angle relative to the central longitudinal axis along a second axis and includes a curved blade (24). The curved blade includes an inner wall (26) that extends to a base (28) of the cutting tip.

Provided herein are cell-free compositions containing the secretome / exosomes of dsRNA primed cells ("herein dsRNA-primed secretome / exosome). The dsRNA-primed secretome is obtained from conditioned media following cell culture (for an effective amount of time) of cells treated with dsRNA, either by transfecting the cells with dsRNA or incubating the cells with dsRNA. The dsRNA-primed secretome / / exosome can be administered to a subject in need thereof, by administering an effective amount of the dsRNA-primed secretome / exosomes to a subject in need thereof. Exemplary subjects / sites of treatment include subjects include, but are not limited to in need of wound healing such as skin wound healing, burn sites, subjects in need of bone repair such as osteochondral bone repair, bone fracture sites, corneal wound sites. Other subjects include osteoporotic subjects and subjects with intervertebral disc degeneration.

Compositions and methods for treating degenerative disc disease in a subject in need thereof are provided. Specifically, the methods include locally administering a therapeutically effective amount of one or more matrix-modifying enzymes to a cartilage endplate to increase the permeability of the cartilage endplate and improve disc nutrient transport.

The application discloses a joint cartilage stress dynamic monitoring system based on flexible sensing and AI and belongs to the technical field of medical health monitoring.The application solves the problem that the prior art can only measure single-point pressure or strain and cannot obtain full-field three-dimensional stress distribution of a cartilage contact surface, and the system function stops at monitoring and does not form a monitoring-to-warning closed loop, quantifies uncertainty through a Bayesian neural network, provides a reliable basis for clinical decision-making, combines multidimensional biomechanical characteristics and an attention mechanism, accurately focuses on a stress key area, significantly improves the precision and individualization level of joint cartilage health evaluation, helps early detection and prevention of injury, classifies stress abnormalities, implements accurate early warning, and formulates an individualized treatment scheme according to uncertainty results and cartilage health indexes, and customizes a rehabilitation training plan according to user conditions, and improves the scientific nature of joint injury prevention and rehabilitation.

A mask system includes a cushion for a mask that seals at its upper extent in a region of the nose that is generally above the tip of the nose or pronasale, and extends across a portion of the cartilaginous framework, alar or flares of the patient's nose, e.g., not extending over or across the nasal bone of the patient's nose.

Provided herein are methods of treating erosive hand osteoarthritis (OA) in a subject in need thereof, methods of reducing radiographic erosive progression, joint space narrowing, cartilage degradation, and / or bone formation in a subject in need thereof (e.g., a subject suffering from erosive hand OA), methods of inhibiting the development of new erosive joints in a subject in need thereof (e.g., a subject suffering from erosive hand OA), and methods of reducing pain in a subject with erosive hand OA. Also provided herein are uses of denosumab in the manufacture of a medicament adapted for use in a method described herein, as well as pharmaceutical compositions comprising denosumab for use in a method described herein.

The invention relates to the technical field of periosteal repair, and particularly discloses a suture anchor for periosteal cartilage defect repair and a using method thereof.The suture anchor comprises at least two anchor bodies, the head of each anchor body is a pointed cone part, and a suture blind hole is formed in the tail of each anchor body; at least one group of threading rods which are arranged at intervals with the bottoms of the threading blind holes are arranged in the threading blind holes; the at least one tail line penetrates through the threading blind hole of the anchor main body; and the anchor main body and the tail line are made of biocompatible materials. After the tail line is tightened, irreversible fixation is achieved through an automatic locking structure, postoperative tail line loosening or periosteum displacement is avoided, and the cartilage regeneration effect is improved.

Systems and methods for articular cartilage thickness mapping and lesion quantification operate on 3D medical image data to reconstruct cartilage surfaces, estimate surface normals, determine cartilage thickness, and identify regions of full-thickness cartilage loss (FCL). Reconstructed cartilage surfaces can be parcellated into subregions using a rule-based approach.

The present invention relates to a stem cell therapeutic agent for preventing or treating temporomandibular joint diseases, and a production method therefor. Specifically, stem cells overexpressing at least one gene selected from the group consisting of IDO, TSG -6, and FGF2 are included as an active ingredient. When used, the agent can prevent cartilage loss in the temporomandibular joint and promote bone regeneration, and thus can be advantageously used for the fundamental prevention and treatment of temporomandibular arthritis.