223 results about "Cartilage" patented technology

The invention discloses a muscle-bone regeneration sustained-release preparation for targeting knee joint cartilage and a preparation process thereof, the preparation is composed of a cartilage targeting peptide modified PLGA-hyaluronic acid composite nanoparticle sustained-release carrier, an active regeneration component, a biocompatible matrix and an anti-inflammatory component, nanoparticles are prepared by a multiple emulsion solvent evaporation method, and targeting peptide is modified; the composite concentrated growth factors, stem cells and traditional Chinese medicine extracts have the functions of targeted enrichment, long-acting slow release, anti-inflammation and cartilage regeneration promotion, and can be used for knee joint cartilage defect repair.

The invention provides a mineralized collagen cartilage repair scaffold and a preparation method and application thereof, and relates to the technical field of biomedical materials.The preparation method comprises the steps that a collagen solution subjected to mineralization treatment is injected into a mold, and a mineralized collagen layer is obtained through deep freezing and primary freeze drying; taking the mineralized collagen layer as a bottom layer, injecting a collagen solution which is not mineralized, and performing deep freezing and first freeze drying to obtain a freeze-dried scaffold; and carrying out crosslinking and secondary freeze drying on the freeze-dried scaffold, and compressing to obtain the mineralized collagen cartilage repair scaffold. A necessary bioactive interface, a continuous interpenetrating structure of a collagenous fiber network and cross-linking treatment are provided for osseointegration, and interlayer separation is avoided; bidirectional regeneration of osteochondral bone is realized, and complexity and risk of clinical application are reduced; in a wet state, good tailorability and enough stiffness are achieved, and meanwhile stable mechanical support is provided; the technical problem that in the prior art, a stent material is insufficient in systematicness of biosecurity of multi-scale structure bionics and interface bonding agents is solved.

The invention relates to the technical field of biomedical materials, in particular to multi-material 3D printing bionic gradient soft-hard integrated hydrogel as well as a preparation method and application thereof. Based on a copolymerization system of high-strength supramolecular N-acryloylglycinamide and vinyl phosphoric acid, an NAGA aqueous solution and an NAGA-VPA aqueous solution are printed into hydrogel of a gradient structure by adopting a DLP multi-material printing technology, then the hydrogel is sequentially soaked in a calcium-phosphorus mixed aqueous solution (Ca / P = 1.67), ammonia water, a calcium chloride aqueous solution and deionized water, and the hydrogel is prepared through a hydrothermal method. Therefore, in-situ gradient deposition and curing of hydroxyapatite (HAP) are realized. The multi-material 3D printing bionic gradient soft-hard integrated hydrogel prepared by the method has a continuous biochemical-mechanical gradient, a surface layer low-modulus area is matched with cartilage performance, a deep layer high-mineralization area is integrated with bone tissue, the HAP crystallinity of a transition area is in spatial dependence distribution, and the hydrogel is suitable for osteochondral defect repair and manufacturing of bionic joint prostheses.

The invention provides a controllable degradation magnesium-based bionic biphasic stent as well as a preparation method and application thereof. The stent comprises a porous magnesium stent, hydrogel and a ceramic coating, the porous magnesium scaffold comprises a cartilage phase scaffold and a subchondral bone phase scaffold which are arranged from top to bottom; hydrogel is arranged on pores and the outer surface of the cartilage phase scaffold, and a ceramic coating is arranged on the surface of the subchondral bone phase scaffold. From the bionic angle, the three-dimensional communicated porous magnesium stent with gradient porosity is designed by simulating the structure, mechanics and other characteristics of joint tissues (upper cartilage and lower subchondral bone); meanwhile, according to the characteristics of joint tissue components, biological properties and the like, hydrogel (an upper cartilage phase) is filled in the stent, and a bioactive ceramic coating (a lower subchondral bone phase) is prepared on the surface of the stent, so that the degradation rate of the biphasic magnesium stent is regulated and controlled, and the cytotoxicity is reduced; meanwhile, the biocompatibility and the biological activity are improved, and endogenous cartilage-subchondral bone integrated repair is realized.

A drill-less method of stabilizing a sacroiliac joint using a multimodal abrading device to create a rich environment for bony fusion. The unique decortication instrument includes an integral slap hammer assembly joined with a rasp-box osteotome tooling head to simultaneously remove cartilage from the joint while preparing the sacrum and ilium down to bleeding bone. Subsequent to joint preparation, an implant with a large bone graft window may be implanted into the prepared SI joint through a specially designed access cannula.

The invention discloses a functional osteochondral repair material which comprises a cartilage layer, a transition layer and a bone layer which are sequentially connected, the cartilage layer takes hyaluronic acid, I-type collagen and chitosan as base materials, the transition layer takes hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, and the bone layer takes hyaluronic acid, I-type collagen and chitosan as base materials. The bone layer takes beta-tricalcium phosphate, hydroxyapatite and a polylactic acid-glycolic acid copolymer as base materials, the invention relates to the technical field of medical biological materials, by designing the organic-inorganic composite transition layer, the gradient connection cartilage layer and the bone layer, and the interfacial shear strength is greater than or equal to 0.5 MPa, the problem of interlayer stripping of a traditional layered material is effectively solved, and the medical material has the advantages of high mechanical strength, high mechanical strength and high mechanical strength. According to the selective laser sintering 3D printing material, the shearing stress and the compression stress during joint movement can be borne, mature medical material production equipment such as freeze drying, compression molding and sintering is adopted in the preparation process, large-scale batch production can be achieved, meanwhile, personalized preparation of selective laser sintering 3D printing is supported, and the requirements of different clinical scenes are met.

This invention provides aragonite- and calcite-based scaffolds for the repair, regeneration, enhancement of formation or a combination thereof of cartilage and / or bone, which scaffolds comprise at least two phases, wherein each phase differs in terms of its chemical content, or structure, kits comprising the same, processes for producing solid aragonite or calcite scaffolds and methods of use thereof.

The application discloses an ankle joint prosthesis, which comprises a tibia component, a pad and a talus component connected in sequence, and a plurality of bionic ligaments; the tibia component comprises a first intramedullary canal handle and a platform connected to the lower end of the first intramedullary canal handle; the pad comprises a pad body, and the upper surface of the pad body is provided with a cylindrical boss; the talus component comprises a second intramedullary canal handle and a connecting piece connected to the upper end of the second intramedullary canal handle; and the bionic ligaments are connected to the pad and the talus component respectively. The ankle joint prosthesis can completely replace the bone and cartilage of the ankle joint surface, thereby overcoming the problem that the cartilage surface cannot be repaired by an ankle arthroscopy surgery. The ankle joint prosthesis is used for replacing the original damaged ankle joint by using metal and polymer components, so that the discomfort symptom is relieved and the joint activity ability is reserved, and the ankle joint prosthesis is a full freedom ankle joint prosthesis which can completely reserve six activity modes of flexion, extension, inversion, eversion, internal rotation and external rotation.

The utility model belongs to the technical field of medical instruments, and particularly discloses a cartilage cortex cutting knife which comprises a knife head. The tool bit is detachably installed at the head end of the handle, and a protection frame is arranged at the head end of the handle to shield the tool bit. The handle is in an arc shape with two protruding sides and a concave middle, and the head end of the handle is an inclined plane tangent to the arc line of the front end of the handle. When cartilage cortex cutting is carried out, under the arc arrangement that the two sides of the handle are convex and the middle of the handle is concave, an operator holds the handle more stably, the tool bit is detachably arranged on the inclined plane tangent to the arc line at the front end of the handle, the operator can apply force better to cut cartilage cortex conveniently, and the tool bit can be detached and replaced conveniently; meanwhile, the protective frame is arranged at the head end of the handle to shield the cutter head, the protective frame can fully shield the cutter head when cartilage cortex is cut, and the cutter head is prevented from accidentally injuring an operator.

Bone and joint surface reconstruction methods are disclosed for the therapeutic amelioration of joint defects caused by various conditions, injuries, and diseases to help eliminate or reduce pain and return the joint to its proper bio-mechanical function without the need to replace fully or partially the anatomical joint. The joint may specifically include mammalian joints such as the femorotibial joint, for example. The methods disclosed herein leverage the significant role the subchondral bone plays in the health status of the afflicted joint.

A surgical cutting device (10) for cutting and removing cartilage from an affected area is disclosed. The surgical cutting device includes an elongated shaft (12) having a proximal portion (18) and a distal portion (20) connected between a proximal end (14) and a distal end (16). A central longitudinal axis extends through the elongated shaft. The proximal portion has a first diameter and the distal portion has a second diameter, the first diameter being greater than the second diameter. The cutting device further includes a cutting tip (22) at the distal end of the elongated shaft. The cutting tip extends at an angle relative to the central longitudinal axis along a second axis and includes a curved blade (24). The curved blade includes an inner wall (26) that extends to a base (28) of the cutting tip.

Compositions and methods for treating degenerative disc disease in a subject in need thereof are provided. Specifically, the methods include locally administering a therapeutically effective amount of one or more matrix-modifying enzymes to a cartilage endplate to increase the permeability of the cartilage endplate and improve disc nutrient transport.

The application discloses a joint cartilage stress dynamic monitoring system based on flexible sensing and AI and belongs to the technical field of medical health monitoring.The application solves the problem that the prior art can only measure single-point pressure or strain and cannot obtain full-field three-dimensional stress distribution of a cartilage contact surface, and the system function stops at monitoring and does not form a monitoring-to-warning closed loop, quantifies uncertainty through a Bayesian neural network, provides a reliable basis for clinical decision-making, combines multidimensional biomechanical characteristics and an attention mechanism, accurately focuses on a stress key area, significantly improves the precision and individualization level of joint cartilage health evaluation, helps early detection and prevention of injury, classifies stress abnormalities, implements accurate early warning, and formulates an individualized treatment scheme according to uncertainty results and cartilage health indexes, and customizes a rehabilitation training plan according to user conditions, and improves the scientific nature of joint injury prevention and rehabilitation.

Provided herein are methods of treating erosive hand osteoarthritis (OA) in a subject in need thereof, methods of reducing radiographic erosive progression, joint space narrowing, cartilage degradation, and / or bone formation in a subject in need thereof (e.g., a subject suffering from erosive hand OA), methods of inhibiting the development of new erosive joints in a subject in need thereof (e.g., a subject suffering from erosive hand OA), and methods of reducing pain in a subject with erosive hand OA. Also provided herein are uses of denosumab in the manufacture of a medicament adapted for use in a method described herein, as well as pharmaceutical compositions comprising denosumab for use in a method described herein.

The invention relates to the technical field of periosteal repair, and particularly discloses a suture anchor for periosteal cartilage defect repair and a using method thereof.The suture anchor comprises at least two anchor bodies, the head of each anchor body is a pointed cone part, and a suture blind hole is formed in the tail of each anchor body; at least one group of threading rods which are arranged at intervals with the bottoms of the threading blind holes are arranged in the threading blind holes; the at least one tail line penetrates through the threading blind hole of the anchor main body; and the anchor main body and the tail line are made of biocompatible materials. After the tail line is tightened, irreversible fixation is achieved through an automatic locking structure, postoperative tail line loosening or periosteum displacement is avoided, and the cartilage regeneration effect is improved.

Systems and methods for articular cartilage thickness mapping and lesion quantification operate on 3D medical image data to reconstruct cartilage surfaces, estimate surface normals, determine cartilage thickness, and identify regions of full-thickness cartilage loss (FCL). Reconstructed cartilage surfaces can be parcellated into subregions using a rule-based approach.

The present invention relates generally to minimally invasive, cost-effective, adaptable methods, systems, and devices used to repair anatomical joint conditions. The repair may be necessitated by trauma, disease or other conditions. The anatomical joint may specifically include mammalian joints such as the knee, shoulder, elbow, wrist, finger, hip, spine, toe and ankle, for example. The methods, systems, and devices disclosed herein include leveraging the significant (and often unappreciated) role the subchondral bone plays in the health status of the afflicted anatomical joint.

A cartilage dicing device according to an embodiment of the present invention includes blades disposed in a housing configured to mitigate entry of the cartilage into the housing of the device. The device includes a number of circular blades used to dice the cartilage in a uniform fashion. The blades are disposed in a housing with a base that prevents the tissue from entering the body of the housing, which ensures that more of the tissue is available to be diced and used in a medical procedure. The blades are spaced at uniform distance.

The invention discloses a suture-containing anchor device for fixing articular cartilage stripping and a fixing method. The device comprises an anchor, a soft needle, a buckle cylinder and a suture; the anchor is made of titanium alloy absorbable materials and is provided with a double-spiral decompression groove and a suture channel. The suture is made of eight strands of ultra-high molecular weight polyethylene coated with polylactic acid, one end is fixed with the anchor, and the other end is welded with a nickel-titanium alloy soft needle through laser; the buckle cylinder is detachable and wraps the suture and the soft needle connecting section. The method comprises the following steps: resetting a bone block and temporarily fixing the bone block, drilling a central bone tunnel, implanting an anchor nail, installing a buckle cylinder, then enabling a soft needle with a suture to penetrate out, drilling a peripheral bone tunnel, threading into a tension band in a bundle splitting manner, adjusting the tension to 0.5-1.2 N / mm < 2 >, and then combining and locking the SMC sliding knot and the surgical knot. Minimally invasive fixation is achieved, mechanical stability and tension uniformity are improved, and cartilage healing is facilitated.

The present invention relates to methods for the treatment of a spinal deformity, such as thoracolumbar deformity in a subject in need of said treatment, said method comprising the step of administering a therapeutically effective amount of an inhibitor of FGFR3 signaling, or an NPR-B agonist and / or an NPR-C agonist to said subject.

The present invention relates to a method of treating spinal malformation, such as thoracolumbar malformation, in a subject in need of such treatment, comprising the step of administering to the subject a therapeutically effective amount of an FGFR3 signaling inhibitor or an NPR-B agonist and / or an NPR-C agonist.

The invention relates to an orthopedic surgery robot registration method, which comprises the following steps of: setting a to-be-registered area of an affected part according to clinical experience, and performing point sampling on the edge of the to-be-registered area through a mechanical arm probe to form a plurality of reference points; acquiring medical image data of the area and fitting to generate a three-dimensional model containing hard bones, cartilage and surrounding tissues; dividing the to-be-registered region into a plurality of sub-regions according to the image data, and adopting a differential acquisition strategy for different types of regions; planning a collection point coordinate in the three-dimensional model of each sub-region and mapping the collection point coordinate to a mechanical arm probe coordinate system; the pose of the mechanical arm is adjusted through pose planning to ensure that all reference points are within the visual field range of the sensor; the robot carries out plane positioning according to the XY coordinates of the collection points, controls the probe based on the Z-axis parameters to achieve accurate point collection according to different clinical requirements, completes automatic point collection, and improves the surgical precision and efficiency.

The utility model relates to the technical field of medical instruments, and discloses a composite support for bone tissue engineering, which comprises a shell, a plurality of fixing rings are equidistantly mounted on the outer wall of a supporting layer, a filter screen is mounted in the middle of the outer wall of each fixing ring, and a fixing block is fixedly connected to the bottom end of each fixing ring. A bottom plate is fixedly connected to the bottom end of the fixing block, a connecting pipe is fixedly connected to the middle of the top end of the bottom plate, a plurality of second medicine outlet holes are formed in the top wall of the bottom plate at equal intervals, a second cavity is formed in the middle of the fixing block and the middle of the connecting pipe, and a first cavity is formed in the middle of the shielding layer and the middle of the supporting layer. According to the utility model, the cavity I can be filled with medicines for diminishing inflammation, relieving pain, resisting infection and promoting cartilage growth, the medicines enter the connecting tube and then flow into the adjacent cavity II from the groove, and then the medicines are guided to a fracture area through the medicine outlet II, so that smooth and rapid growth of bone tissue cells can be effectively promoted, and damaged bone tissue can be repaired.

The invention discloses an injectable hydrogel pharmaceutical composition for an articular cavity as well as a preparation method and application of the injectable hydrogel pharmaceutical composition. The hydrogel pharmaceutical composition comprises gel particles and a medicine loaded in the gel particles, the gel particles are formed by cross-linking hyaluronic acid or salt thereof and silk fibroin through a cross-linking agent; the medicine comprises an anti-inflammatory drug and / or a growth factor. The preparation method is simple, good in safety and beneficial to industrial production. The uniform porous structure of the hydrogel is beneficial to adhesion and growth of bone cells, meanwhile, the double-load hydrogel loaded with the anti-inflammatory drug and the growth factor has good viscoelasticity and injectability and has the effects of synergistically resisting inflammation and promoting cartilage repair, and bone joint related diseases are treated in a bone joint intracavity injection mode; the drug residence time can be prolonged, and the bioavailability is improved.

The utility model relates to the technical field of medical apparatus and instruments, and provides an adjustable prosthesis adaptive to human body annular cartilage replacement, which comprises a cartilage arch support which can be arranged at a to-be-repaired position of a human body annular cartilage; the cartilage arch support comprises the first supporting part and the second supporting part, and due to the fact that the first supporting part and the second supporting part are coaxially hinged, the size of the cartilage arch support can be adjusted by adjusting the included angle between the first supporting part and the second supporting part when the cartilage arch support is used for patients with different annular cartilage injury degrees. Therefore, the applicability of the prosthesis can be improved. Moreover, compared with personalized customization for different individuals, the prosthesis is beneficial to improving the efficiency of repair treatment, and the treatment cost is also reduced. Moreover, the first supporting part and the second supporting part are both of a curved-plate-shaped structure, so that the appearance of the whole cartilage arch support is more adaptive to the annular cartilage of the human body, and the cartilage arch support is attractive while being repaired.

An image generation device (4) comprises: a storage device (42) for holding first image data obtained by using an X-ray inspection device (1) to perform imaging of a part of an animal that includes a bone inside; and a generation unit (431) that has a trained machine learning model (432), inputs the first image data to the machine learning model (432), and thereby generates second image data indicating the bone and a cartilage region that is estimated from the position of the bone and is continuous with the bone.

The hip bone protection composite material with the invisible wearing feature comprises, from the impact surface to the skin surface, in sequence: a sensing enhancement layer composed of modified three-dimensional spacer fabric loaded with shear thickening fluid, the fiber surface of the three-dimensional spacer fabric is subjected to lyophobic modification treatment to form reverse capillary resistance to STF carrier liquid, and the contact angle θ is greater than or equal to 110 degrees; and a bionic buffer layer composed of artificial cartilage bionic energy absorption material and having a microporous structure; wherein the sensing enhancement layer and the bionic buffer layer are combined through dot matrix gluing or ultrasonic welding, and the edge thickness of the composite material decreases linearly or nonlinearly from the center to the periphery to form a gentle slope structure with a thick center and a thin edge. The invention combines the shear thickening technology and the bionic energy absorption technology to solve the contradiction of traditional protective equipment in the aspects of 'protection-thin-breathability', and provides an intelligent material with an ultra-thin thickness, a normal softness and an impact instantaneous hardening.

The invention relates to the technical field of biomedical materials, in particular to a super-lubricating composite material for bionic cartilage and subchondral bone and a preparation method of the super-lubricating composite material. The super-lubricating composite material is formed by compounding a hydrogel precursor, a polyvinyl alcohol aqueous solution and a functional filler under an alkaline condition, the hydrogel precursor is prepared by carrying out a reaction on sodium alginate, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and m-aminophenylboronic acid in deionized water, and the hydrogel precursor is prepared by carrying out a reaction on the sodium alginate, the 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and the m-aminophenylboronic acid; the composite material prepared by the invention has excellent mechanical properties, elastic modulus of bionic cartilage and extremely low friction coefficient, and also has excellent lubricating stability and self-repairing function, so that dynamic repairing and lubrication maintenance of a damaged interface are realized; the material is particularly suitable for a bionic cartilage layer in femoral head necrosis area replacement, friction between an implant and original cartilage can be effectively reduced, cartilage repair is promoted, and the joint function is improved.

The invention discloses an RIP3-mediated osteoarthritis animal model as well as a construction method and application thereof. The construction method comprises the following steps: delivering an effective dose of a genetic tool (such as an adenovirus vector) capable of expressing RIP3 protein into a knee joint subchondral bone area of an experimental animal, and realizing continuous overexpression of RIP3 through regular operation, so as to induce pathological characteristics highly similar to human osteoarthritis. The model stably shows typical OA phenotypes such as limb pain sensitization, subchondral bone loss and bone microstructure degeneration, osteoclast number increase and overlying cartilage degeneration. The invention reveals that the natural process of occurrence and development of the osteoarthritis can be directly simulated through specific overexpression of the RIP3 in the subchondral bone for the first time, and a brand-new and valuable tool is provided for researching the pathogenesis of the osteoarthritis and screening and evaluating medicines and therapies for treating the osteoarthritis.

The invention relates to the technical field of functional food, in particular to an electrolyte composition beneficial to joint injury repair after exercise and a preparation method of the electrolyte composition. The electrolyte composition is mainly prepared from the following raw materials in parts by mass: 0.1 to 2 percent of N-acetylglucosamine, 0.05 to 0.5 percent of cartilage extract, 0.05 to 0.5 percent of enzymolysis bone meal, 0.01 to 0.05 percent of milk mineral salt, 0.1 to 1 percent of collagen peptide, 0.01 to 0.3 percent of vitamin and 0.03 to 0.3 percent of electrolyte. The nano hydrated milk mineral salt is adopted, the absorption efficiency of elements such as calcium and phosphorus in a body is improved, and the electrolyte composition is prepared by combining components such as N-acetylglucosamine and the cartilage extract, so that joint inflammation and cartilage injury caused by exercise are effectively improved while water and electrolyte are supplemented, and the activity of joints and exercises is improved. The electrolyte composition is good in taste, high in stability and suitable for joint protection and nutrition supplement after exercise.