626 results about "Biocompatibility" patented technology

This invention provides a breathable plaster matrix for application and its preparation method, belonging to the field of polymeric dressings and plasters. The plaster matrix raw materials include terpene-modified rosin beeswax, hydrogenated rosin glyceryl ester, camellia oil, castor oil, stearic acid hydrophobically modified microcrystalline cellulose, zinc oxide, glycerin, coated citric acid, sodium bicarbonate, polyethylene glycol, camphor, and menthol. The terpene-modified rosin beeswax is prepared by reacting rosin and α-pinene in the presence of di-tert-butylperoxyisopropylbenzene, followed by the addition of white beeswax and maleic anhydride, and then the addition of trimethylolpropane. The stearic acid hydrophobically modified microcrystalline cellulose is microcrystalline cellulose coated with stearic acid. The coated citric acid is citric acid coated with hydrogenated castor oil. This invention's plaster matrix significantly improves skin breathability, application comfort, and biocompatibility while ensuring sufficient adhesion, formability, and drug loading capacity.

The application discloses a pinacine alkyl tetrahydrocarbazole fluorescent probe capable of detecting cell lysosome polarity and a preparation method and application thereof. 9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-formaldehyde is used as raw material, and condensation reaction is carried out with 1,3-indan dione to obtain compound 2-(2-(9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-yl)vinyl)-1-indene-1,3(2H)-dione (TC-AP-ID), and the probe can specifically detect the polarity of cell lysosomes. In a mixed system of 1,4-dioxane and water, with the increase of the polarity of the system, the fluorescence color of the probe gradually changes from orange to red, and the fluorescence intensity significantly decreases. The probe has the advantages of simple synthesis, good selectivity, high sensitivity, good biocompatibility, low toxicity and the like, can be applied to targeted detection of the polarity of cell lysosomes, and has a good application prospect.

The application relates to a light-degradation-driven high-molecular nanomotor and a preparation method, and aims to solve the environmental pollution and biological safety problems caused by the degradation difficulty or long cycle of the nanomotor power assembly. The nanomotor has an asymmetric nanostructure and is assembled by a light-degradation high-molecular assembly and a biocompatible high-molecular effective load in a nanometer scale. The preparation method comprises the following steps: 1. uniformly mixing a light-degradation high-molecule and a biocompatible high-molecule in an organic solvent to prepare a mixture A; 2. mixing the mixture A and water at a high speed to prepare a mixture B; and 3. removing the organic solvent to prepare the nanomotor. Under light, the light-degradation assembly absorbs light energy to degrade and generate bubbles, which push the nanomotor to move in the solution. The start / stop of the nanomotor is controlled by the on / off of the light source, and the fast / slow movement of the nanomotor is controlled by the strong / weak of the light source. The structure of the light-degradation assembly is gradually degraded and finally completely destructed with the reaction, so that the biological safety and environmental pollution problems of the nanomaterial are relieved.

This invention provides an anti-aging and repair dressing containing four complex active factors and its preparation method. The dressing comprises 75-90 parts of a matrix material, 5-15 parts of four complex active factors, and 3-8 parts of a moisturizing auxiliary agent. The four complex active factors are composed of recombinant human type III collagen, acetyl hexapeptide-8, ectoine, and dipotassium glycyrrhizate in a ratio of (3-6):(1-3):(2-4):(1-2). The matrix is ​​a hydrophilic nonwoven fabric or bio-cellulose membrane material that has undergone low-temperature plasma surface grafting activation treatment. The preparation process employs nitrogen combined with vacuum pulse freeze-drying technology, and enhances the activity stability through an ectoine complexation step. This dressing can promote HaCaT cell proliferation, increase collagen secretion, and inhibit inflammatory factors, significantly improving skin barrier function. It has good biocompatibility and can be used to prepare products that improve skin aging and repair.

The application provides a non-invasive implantable wall deformation volume sensor, and relates to the technical field of implantable biomedical sensors, which comprises an elastically deformable closed ring-shaped base, a conductive coil arranged on the ring-shaped base, a capacitor forming an LC resonant circuit with the conductive coil, an elastic support structure arranged in the ring-shaped base, and a biocompatible encapsulation layer covering the outside. The sensor controls the distribution ratio and mechanical rigidity of the support structure, so that the ring-shaped base produces controllable concave deformation under the action of the pressure of the inner wall of an organ, thereby changing the geometric parameters of the conductive coil and causing the resonant frequency to change, and the detection of the volume change of the organ is realized. In addition, the elastic support structure and the ring-shaped base form a connection mode allowing relative sliding, so that the sensor can automatically expand by the elastic force after compression delivery. The application can respond to the overall geometric deformation, and has the advantages of simple structure and high mechanical compliance.

The present application belongs to the technical field of condensate, and particularly relates to a non-peptide small molecule condensate and preparation and application thereof. The present application provides a non-peptide small molecule condensate which is prepared by taking a small molecule shown in formula I as a precursor, wherein Y and Z are each independently NH, O or S, R = or X = O or S; R1 and R2 are each independently selected from H, C 3‑20 alkyl, -C 1‑8 alkylene-phenyl, -C 1‑8 alkylene-5-10-membered heteroaryl, -C 1‑8 alkylene-S-C 1‑8 alkyl, -C 1‑8 alkylene-SH, -C 1‑8 alkylene-O-C 1‑8 alkyl or -C 1‑8 alkylene-NH-C 1‑8 alkyl; and R1 and R2 are not H at the same time. The obtained condensate not only has good spontaneous non-classical fluorescence characteristics, but also has the abilities of drug loading and controllable release, and shows excellent resistance to enzymatic hydrolysis and good biocompatibility. Formula I

The application relates to the technical field of medical dressing preparation, and discloses a hemostatic, healing-promoting and antibacterial foam dressing and a preparation method thereof. The method uses sodium alginate and carboxymethyl chitosan as a composite polysaccharide matrix, mixes the two, adds a calcium chloride solution to crosslink a porous gel support, and then carries out freeze-drying to obtain a porous framework; gelatin and polyvinyl alcohol can be further added to enhance the mechanical strength, zeolite particles loaded with silver ions are added to achieve antibacterial performance, epidermal growth factor release microspheres are added to promote healing, and the dressing can be further subjected to heparinization, plasma surface modification, thrombin addition, salt precipitation pore formation and sterilization treatment. The dressing prepared by the method has the functions of synergistic hemostasis, antibiosis and healing promotion, has good biocompatibility and suitable mechanical strength, and has a simple preparation process, and can be used for various wound care.

The application provides a titanium alloy surface antibacterial material and a preparation method and application thereof, and comprises a metal phosphide coating constructed on a titanium alloy substrate surface through a plasma immersion injection process and a chemical vapor treatment process and application of the metal phosphide coating in antibacterial medical materials. The coating of the technical scheme has good sterilization function and biocompatibility.

The application discloses a gelatin-based medical consumable and a sterilization process thereof. The consumable comprises a gelatin main material and a biocompatible auxiliary component. The gelatin is pre-crosslinked to form a three-dimensional network structure, and can be made into a porous sponge, a film, a fiber felt, a particle, a columnar body, a sheet body or a gel block. The sterilization process is used for a pre-crosslinked consumable which has been formed. Radiation sterilization, ethylene oxide sterilization or combined sterilization is adopted. According to the sterilization route, the water content, the packaging atmosphere, the radiation dose, the ethylene oxide concentration and the resolution condition are controlled, so that the sterilization treatment mainly plays a sterilization role and does not damage the gelatin main network. After sterilization, the strength retention rate of the consumable is not less than 85%, the swelling ratio retention rate is not less than 80%, the degradation time change rate is ± 20%, and the gel fraction change rate is not more than 10%.

This invention discloses an interlocking bone tissue repair scaffold, assembled from several notched links connected in an interlocking manner. The notches in one link allow passage through the notches in another link, but not through the remaining main body of the other link. The links are 3D printed from calcium phosphate ceramic powder. The porosity of the final assembled chain can be flexibly controlled by adjusting the shape, size, thickness, and combination of links of different sizes, allowing for precise customization according to specific application scenarios. This scaffold structure is flexible and adjustable, adaptable to different implantation areas, significantly expanding the product's applicability. After implantation, it creates a microenvironment more closely aligned with human tissue growth patterns, optimizing local tissue compatibility and providing excellent conditions for cell adhesion, retention, and proliferation, effectively improving the scaffold's biocompatibility and clinical application efficacy.

There is provided a method for decreasing leakage of matter from an object to a surrounding, said object being coated with a coating at least partially applied on the object, said coating comprising an at least partially covering layer comprising silver, said object optionally comprising area(s) without said layer, said coating comprising metal particles applied on the layer and optionally on areas without said layer, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, niobium, neodymium and platinum and wherein the amount of the metal particles is in the interval 0.01-8 μg / cm . Advantages include that leakage of matter such as latex allergens of metal ions can be reduced while the coating is both biocompatible and antimicrobial. Further, the blood clotting can be reduced.

This application discloses an embedded whole-cell biosensor, its fabrication method, and its application in machine learning-assisted mercury ion detection, belonging to the field of sensor materials and detection technology. This sensor encapsulates *E. coli* expressing green fluorescent protein (GFP) in a polyacrylamide / hyaluronic acid (PAAM / HA) hydrogel matrix, enabling highly selective and sensitive detection of mercury ions. It effectively eliminates interference from competing metal ions and can be completely regenerated through EDTA-2Na treatment, allowing for repeated use without performance loss. It maintains a stable fluorescence response for up to three weeks, possesses excellent biocompatibility and biodegradability, minimizing the risk of secondary contamination, and facilitates rapid on-site analysis.

The disclosure relates to compositions useful for ligament and tendon repair and methods of preparing the same. The disclosure is particularly suitable for repair of ligament ruptures, for example, anterior cruciate ligament ruptures. In an aspect of the invention, the compositions comprise a biocompatible clay, a polymer, a polypeptide, a calcium-based mineral that form a scaffold, as well as a bioabsorbable reinforcement structure incorporated thereon and / or therein. Methods of use and manufacture of the compositions, as well as kits including the compositions, are also provided.

The application belongs to the field of medical materials, and particularly relates to a metal core enhanced double-barrier piezoelectric nano system and a preparation method and application thereof. The preparation method comprises the following steps: first, a core-shell structure of'metal@mesoporous titanium dioxide@mesoporous barium titanate' is prepared through a step-by-step reaction, and then the target nanoparticles are obtained through lipid wrapping. The system innovatively constructs a double-barrier structure, can self-trigger active oxygen under a physiological pressure of 4 mmHg, realizes endogenous pressure self-driven treatment of malignant ascites, has the advantages of low pressure, high catalytic efficiency, long-term structural stability and good biocompatibility, solves the problems that existing treatment methods are highly invasive and depend on exogenous stimulation, and provides a new safe and efficient technical scheme for the treatment of malignant ascites.

The application discloses application of a cerium monatomic functional material in preparation of a tumor radiotherapy sensitizer. SA In the material, cerium is dispersed on a nitrogen-doped carbon carrier in a monatomic form and forms a stable coordination structure with N / O. The application determines the structure-activity relationship of the unique physical and chemical structure and multiple enzyme activities, verifies the radiotherapy sensitization effect and biological safety in and out of the body. The material has multiple enzyme activities such as simulating peroxidase and glutathione oxidase, can efficiently catalyze ROS and consume GSH, and enhances DNA damage and apoptosis induced by ionizing radiation. In vitro clone formation experiments show that the radiotherapy sensitization ratio reaches 1.38, which is better than that of CeO2 nano clusters (1.17). In vivo experiments on tumor-bearing mice prove that the material combined with radiotherapy can significantly inhibit tumor growth, prolong survival time, and has good biocompatibility. The application provides a new strategy of high efficiency and low toxicity for tumor radiotherapy sensitization, and has a good clinical application prospect.

This invention relates to the field of biomaterial preparation technology, and in particular to a morphology-controllable mesoporous hydroxyapatite nanosphere, its preparation method, and its applications. The preparation method includes: S1, mixing an aqueous solution of pyridoxal phosphate with an aqueous solution of calcium chloride, adjusting the pH of the mixed solution to 7-11 to obtain a precursor solution; S2, placing the precursor solution in a microwave reactor for reaction to obtain mesoporous hydroxyapatite nanospheres. The preparation method provided by this invention is simple, the reaction conditions are easily controlled, and it is highly safe and reliable. It enables precise control of the morphology and particle size of the hydroxyapatite microspheres, and the prepared product exhibits excellent biocompatibility and structural regularity. It has good industrial application prospects in the field of biomedical implants such as bone tissue repair and is suitable for large-scale production.

This invention relates to the field of biomedical materials technology, specifically disclosing a hydrogel material for spinal cord nerve repair containing magnetic nanospheres and its preparation method. The hydrogel material provided by this invention is a photocurable hydrogel formulated using chitosan, dimethylaminoethyl methacrylate, methacryloyloxyethyltrimethylammonium chloride, and magnetic iron oxide nanospheres. Compared with traditional spinal cord nerve repair materials, the hydrogel material provided by this invention has good biocompatibility, is safe and non-toxic, and has a simple and easy preparation method. Photocuring is performed when the hydrogel is injected into the spinal cord injury site, while a magnetic field is simultaneously applied to the injury site. This causes the magnetic nanospheres to rotate according to the magnetic field, forming a series of magnetic channels. As the hydrogel gradually solidifies, the magnetic channels are permanently retained. During the spinal cord nerve repair process, the magnetic channels guide nerve growth, preventing incorrect nerve connections and ensuring the effectiveness of nerve repair.

The invention relates to a corneal inlay for a human eye, wherein the inlay comprises a biocompatible base material and a colorant that mimics the optical appearance of the iris of a human eye. The invention also relates to a method for changing the visible eye color of a human eye, comprising the steps of preparing a pocket in the cornea of ​​the eye and inserting an implant into the corneal pocket, wherein the implant is configured as a corneal inlay comprising a colorant to simulate an iris, and a method for preparing a corneal inlay for a human eye, comprising the steps of providing a biocompatible base layer and applying a colorant to the base layer, wherein the colorant mimics the optical appearance of the iris of a human eye.

The application discloses a novel zinc-copper prussian blue analogue composite nanomaterial and a preparation method and antibacterial application thereof. The preparation of the material comprises the following steps: S1: Zn(NO3)2.6H2O, Cu(NO3)2.3H2O, Na3C6H5O7.2H2O and AgNO3 are dissolved in deionized water to obtain solution A by stirring; S2: K3[Fe(CN)6] is dissolved in deionized water to obtain solution B by stirring; S3: solution B is slowly poured into solution A, and the mixture is aged at room temperature, centrifuged, washed and vacuum dried; and S4: the dried product is calcined to obtain the final product. The composite nanomaterial has excellent broad-spectrum antibacterial activity, various catalytic activities (POD, GSHOx and CAT) of simulated natural enzymes and good biocompatibility, and has great application potential in the fields of antibacterial treatment, anti-biofilm infection and biomedicine.

The application discloses a kind of sustainable oxygen production sonodynamic therapy nanoparticles, including core-shell structure, the core of core-shell structure is located in shell inside, the core of core-shell structure is manganese oxide nanoparticle, the shell of core-shell structure is the high molecular polymer of carrying sound sensitizer, manganese dioxide nanoparticle is manganese dioxide nanoparticle, sound sensitizer is one of porphyrin and its derivatives, high molecular polymer is polylactic acid glycolic acid copolymer, this kind of sustainable oxygen production sonodynamic therapy nanoparticles by using high molecular polymer simultaneously carrying manganese dioxide nanoparticle and sound sensitizer to enhance SDT effect, high molecular polymer has good biocompatibility and drug controlled release performance, not only can reduce the toxicity of manganese dioxide to normal tissue, can also make it continuously controllable with tumor site excess H2O2 Reaction generates oxygen, reverses tumor hypoxic microenvironment while providing sufficient oxygen for SDT, under the action of ultrasound, generate a large amount of ROS to inhibit tumor.

The application discloses a kind of phytosphingosine inclusions and its preparation method and application, belong to daily chemical technical field.The phytosphingosine inclusion of the application uses maltodextrin and gum arabic as embedding carrier, and the mass ratio of maltodextrin and gum arabic in embedding carrier is 1:1~3.The phytosphingosine of the application is modified by screening embedding carrier and optimizing embedding process, and the water solubility of the obtained phytosphingosine inclusion is significantly improved, which can increase the addition amount in daily chemical products, improve the skin care effect of moisturizing, repairing skin barrier and anti-aging, etc.The embedding carrier used in the application has good biocompatibility, no skin irritation, high safety;Moreover, the embedding process step is simple, without complex equipment, easy for large-scale industrial production, and the production cost is controllable, with good market application prospect.

The application belongs to the technical field of biological medical materials, and discloses a polydopamine modified modified nano-graphyne and a preparation method and application thereof. In the method, the polydopamine coating is combined with the nano-graphyne for the first time to construct a GDY@PDA composite system, and the core defects of the blocky graphyne, such as easy agglomeration, poor water solubility and insufficient biocompatibility, are solved. The graphyne-based material is applied to the near-infrared two-region photothermal regulation of neural cell calcium influx for the first time, the calcium ion channel is activated through the local thermal effect of the material, and precise, remote and reversible calcium influx regulation is realized; the limitation that the traditional biocompatibility modification is easy to fall off and difficult to functionalize is broken through, the polydopamine modification makes the material have both photothermal efficiency and biological safety, and the application of the graphyne in the treatment of neural diseases (such as neural cell injury repair) is expanded.

The present application relates to the technical field of biochip, in particular to a multi-waveband synergic release permeation-quantitative biochip, which comprises a substrate, a permeation function layer and a gold plating layer stacked from bottom to top; the substrate is made of graphene material with a thickness of 0.05-0.1mm, used for receiving and storing environmental energy; the permeation function layer has a thickness of 0.1-0.3mm, which is made of a mixture of nano far infrared powder, anion powder, magnetic powder and nano catalytic material with a mass ratio of 3:2:2:1, and then compounded with a biocompatible adhesive; the present application simultaneously releases magnetic wave, far infrared wave, anion wave and quantitative wave, and has the dual functions of human physiotherapy and material purification, solves the problem of single function of the existing products, the energy storage capacity of the graphene substrate and the energy aggregation effect of the gold plating layer greatly improve the energy utilization efficiency, prolong the chip action time, the permeation technology strengthens the waveband penetration capacity, and when acting on the human body, it does not need to be pasted on the skin, and when acting on the material, it does not need to be soaked, and the use scene is flexible.

The application relates to the technical field of biological materials, and mainly relates to a cell mitochondrial organic fluorescent probe and a preparation method thereof. The cell mitochondrial organic fluorescent probe comprises the following structural formula: The cell mitochondrial organic fluorescent probe provided by the application has the effect of targeting cell mitochondria, accurate positioning, good biocompatibility, AIE characteristics and low cytotoxicity, does not need washing operation, can avoid water washing, makes the dyeing process more convenient and economical, is an excellent mitochondrial imaging material, and can effectively realize rapid targeted positioning and imaging of mitochondria.

The application discloses a periapical tissue regeneration type root canal paste, a preparation method and application thereof. The periapical tissue regeneration type root canal paste is composed of Iroot-sp paste and additives, and the mass ratio of the Iroot-sp paste to the additives is 60-80:20. The root canal paste is used for oral tissue regeneration and root canal filling and barrier. Compared with the sealant in the prior art, the root canal paste has great improvement in biocompatibility and remineralization capacity.

The present application relates to a controllable degradation of siliconized DNA hydrogel and its preparation method and application, the hydrogel is assembled into a three-dimensional network through the DNA structure with single-stranded region in the center and linear DNA structure, and the mechanical properties and thermal stability thereof are improved through in-situ siliconization. The precisely designed single-stranded region can still be recognized and degraded by specific nucleic acid enzyme after siliconization, realizing the accurate control of selective degradation. Taking human umbilical vein endothelial cells as an example, the present application verifies the good biocompatibility of the material, and the present application can be used for cell embedding and release, and is suitable for advanced biological materials, medical, pharmaceutical and other research and application fields such as organoid culture, tissue engineering and controllable drug release.

The application discloses a kind of high adhesion hydrogel for electroencephalogram test and its preparation method and application, belong to biomedical engineering technical field.The hydrogel includes the following components crosslinked product: anionic monomer, cationic monomer, monomer and mutual penetration agent;The anionic monomer is any one of malic acid, gluconic acid, citric acid and lactic acid, cationic monomer is betaine or acetyl L-carnitine, monomer is N, N-dimethyl acrylamide, acrylic acid, sodium acrylate, 4-acryloyl morpholine or sodium acrylamidomethyl propane sulfonate, mutual penetration agent is sodium chloride aqueous solution or sodium chloride water-retaining agent solution.Preparation, cationic monomer is mixed and dissolved, vacuum drying, adding photo initiator mixing, then mutual penetration agent is added, and it is obtained by ultraviolet light crosslinking.The hydrogel of the application has high adhesion (adhesion strength reaches 203.22 kPa), high ion mobility and excellent biocompatibility, and the signal gain in EEG and ECG test reaches 2-3 times of traditional conductive paste, which can be widely used in medical conductive paste field.

The present invention relates to: a stem cell isolation kit manufacturing composition prepared with graphene dispersed therein, and a preparation method therefor, the composition enabling cell activity of stem cells to improve and blood clots to be prevented through mixing of graphene and a thermoplastic resin. The stem cell isolation kit manufactured using the stem cell isolation kit manufacturing composition comprising graphene, of the present invention, allows autologous stem cells to be activated by an environment in which biocompatible far-infrared (FIR) emission and electrical conductivity are increased, and, under hypoxic conditions, enables stem cell water amount to be increased through low oxygen permeability (water activity). In addition, the present invention is subjected to antibacterial treatment so as to provide an antibacterial effect, and can improve a platelet adsorption reduction rate through a water slip effect of the graphene composition.

The application belongs to the field of biomedical materials and biomedical engineering technology, and discloses a natural hydrogel nanoparticle with mecobalamin sustained release and a preparation method and application thereof. The preparation method is as follows: calcium carbonate nanoparticles are dispersed in water, loaded with mecobalamin to obtain drug-loaded nanoparticles; boric acid is modified on silk fibroin to obtain boric acid-modified silk fibroin; purified peach gum is reacted with sodium periodate under light-proof conditions to obtain aldehyde-modified peach gum; the drug-loaded nanoparticle suspension is mixed with the aldehyde-modified peach gum, and then the boric acid-modified silk fibroin is added to obtain the natural hydrogel nanoparticle with mecobalamin sustained release. The hydrogel has excellent biocompatibility, drug sustained release, self-repair and other functions, and can be applied to nerve injury repair.

The application provides a biocompatible biological aerogel material and a preparation method thereof, and the method comprises the following steps: cleaning and roughening pretreatment of a substrate; dissolving polyvinyl alcohol to prepare a precursor solution; introducing wear-resistant reinforcing materials into the precursor solution and uniformly dispersing the wear-resistant reinforcing materials; adding a crosslinking agent, glutaraldehyde, to perform a crosslinking reaction and construct a three-dimensional network structure; coating the system in the initial stage of crosslinking on the substrate, and performing low-temperature or freeze-drying and subsequent heat treatment to form a stable coating. The obtained material takes polyvinyl alcohol as a biocompatible skeleton, and has excellent porous structure, mechanical properties and wet stability through chemical crosslinking and reinforcing phase compounding. In-vitro cell experiments show that the material has no obvious toxicity to cells, and the cells adhere and spread well. The application solves the problem that the existing biological aerogel material is difficult to consider the biocompatibility, structural stability and process friendliness, and is suitable for the biomedical field such as tissue engineering scaffolds and wound dressings.