18 results about "Biocompatible coating" patented technology

The present invention provides methods, compositions, systems, and kits comprising nano-satellite complexes and / or serum albumin carrier complexes, which are used for modulating antigen-specific immune response (e.g., enhancing anti-tumor immunity). In certain embodiments, the nano-satellite complexes comprise: a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core; b) at least one satellite particle attached to, or absorbed to, the biocompatible coating; and c) an antigenic component conjugated to, or absorbed to, the at least one satellite particle component. In certain embodiments, the complexes further comprise: d) a type I interferon agonist agent. In some embodiments, the serum albumin complexes comprise: a) at least part of a serum albumin protein, b) an antigenic component conjugated to the carrier protein, and c) a type I interferon agonist agent.

The application relates to a concrete ecological revetment pile and relates to the technical field of revetment piles, which comprises a composite revetment pile body, wherein the composite revetment pile body is a three-layer composite structure. The three-layer composite structure of the composite revetment pile body cooperates with an ecological guiding assembly, a steel reinforcement framework pre-buried in a high-strength concrete core layer provides basic structural strength, a first filler in a self-repairing concrete layer realizes self-repairing of cracks, a second filler in a porous recycled concrete layer creates a plant growth environment, a top nutrient soil layer and a bottom nutrient soil layer in a top reserved cavity in the ecological guiding assembly are communicated with ecological holes in a honeycomb distribution through a macromolecular fiber net and a biocompatible coating on the inner wall of the ecological holes, the survival rate of vegetation is improved, and plant root systems can grow transversely through the ecological holes and interweave with plant root systems in the interiors of adjacent composite revetment pile bodies to form a net-shaped structure and enhance overall stability.

An implantable pressure sensor. In some embodiments, a system includes a pressure sensor. The pressure sensor may include: an AT-cut quartz crystal configured to measure pressure, and a biocompatible coating, covering the AT-cut quartz crystal.

The invention belongs to the technical field of animal model construction, and particularly relates to a spinal cord hypertension syndrome disease model modeling method and application. A guinea pig or a macaque is used as an experimental animal, and a composite biostimulation material and an accurate pressure regulation and control modeling system are combined to realize modeling. The composite biostimulation material is composed of a core pressure slow-release layer, a middle biocompatible coating and a surface targeting binding layer, has excellent biocompatibility, degradability and targeting property, and can reduce non-specific inflammatory response; the precise pressure regulation and control modeling system comprises a pressure sensing module, a micro-injection module, a real-time monitoring module and a main control module, and can dynamically regulate and control the pressure in the spinal cord in a closed-loop mode. The modeling method is easy and convenient to operate and good in repeatability, the model building success rate exceeds 95%, the pathological features are highly similar to clinical features and can last for 4 weeks, a reliable experimental model is provided for mechanism research, drug screening and therapeutic schedule evaluation of the spinal cord high pressure syndrome, and the modeling method is suitable for large-scale popularization.

The present invention relates to an apparatus for softening a crystalline lens nucleus (100) in a cataract phacoemulsification treatment comprising an electric current pulse generator (11) to supply a pulse current to a handpiece (12), wherein the pulse current generates a pulsatile magnetic field, and to hydrodissect the lens nucleus with iron oxide nanoparticle solution to loosen the lens nucleus as well as to infiltrate the lens nucleus (14) with the iron oxide nanoparticles (13), characterised in that the needle tip (24) of the handpiece (12) conducts the generated pulsatile magnetic field to the lens nucleus which causes vibration of iron oxide nanoparticles which emanates a mechanical force to break interdigitating bonds between lens fibers, leading to a controlled softening and fragmenting of the lens nucleus, wherein the electric current pulse generator (11) is configured to produce pulse currents with adjustable voltage and frequency parameters, and the iron oxide nanoparticle solution (13) further comprises a superparamagnetic property functionalised with a biocompatible coating.

Suturing materials for producing medical devices are provided. The suture material may include natural fibers, and may be suitable for use in the manufacture of multifilament sutures and surgical meshes containing multifilament sutures, as examples of medical devices. The multifilament suture may include a plurality of filaments combined together in a twist pattern, and at least one of the plurality of filaments may include natural fibers, synthetic fibers, or mineral-based fibers. The suture device may include a multifilament suture in combination with a suture needle. The multifilament suture may be coated with a biocompatible coating (e.g., a bioactive agent) and / or include a first set of filaments including natural fibers and a second set of filaments including, for example, natural fibers, synthetic fibers, or mineral-based fibers different from the natural fibers in the first set of filaments.

The application discloses a hyperspectral microscopic imaging analysis system for label-free tumor tissue, comprising a super surface slide, a hyperspectral imaging system and a medical optical analysis algorithm system connected in sequence; the super surface slide comprises a glass substrate, a super surface microstructure and a biocompatible coating arranged in sequence from bottom to top, and a tissue slice is placed on the super surface microstructure. The application aims at the problems of high cost, low sensitivity, difficulty in early diagnosis and excessive dependence on doctors' experience of the current traditional cancer diagnosis technology, realizes the differentiation and identification of tumor tissue in a label-free manner in the visible light range, develops a spectral imaging system with fast, dynamic and high spectral resolution together with an image sensor, extracts spectral information in the form of image position to assist doctors in pathological diagnosis, and reduces the possibility of missed diagnosis or misdiagnosis.

The invention discloses a high-strength titanium alloy bridge frame for tooth implantation, which belongs to the technical field of implantation bridge frames, and comprises a bridge frame body, an implantation abutment assembly, a composite locking mechanism and an elastic buffer assembly, the bridge body is integrally formed by Ti-6Al-4V ELI titanium alloy and a zirconium element composite modified material, an arc-shaped avoiding groove is formed in the bottom of the bridge body, and the inner wall of the bridge body is covered with a composite biocompatible coating. The composite locking mechanism extrudes an expansion sleeve with an open slot through a conical expansion section of a locking bolt, so that the composite locking mechanism is stably matched with the fixed base station; the elastic buffer assembly is composed of a buffer spring and a medical silicone rubber buffer pad, and can effectively absorb the occlusion impact load. Gaps are prevented from being generated through a double locking structure, the impact resistance is improved in combination with the buffering assembly, the bridge is stably fixed for a long time in cooperation with a high-strength biocompatibility material, the service life of the implant system is prolonged, meanwhile, the implant system has good oral cavity tissue adaptability, and the implant system is suitable for implant repair scenes with dentition defects or missing.

Manufacturing techniques for fabricating a polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one another with a multitude of tiny micropillars or other spacers extending between them, keeping the bag at a predetermined thickness and preventing the bag from collapsing and the sides from sticking together. In other embodiments, the sides may be held apart by gas pressure alone. A 0.01 μm to 1000 μm parylene or other biocompatible coating over the bag outsides controls the permeability of the bag material and provides a bio-safe area for cell growth. An alternate configuration uses open-cell foam with skins coated with a biocompatible coating. Tubes going into multiple bags can be connected to a manifold that delivers gaseous oxygen or removes carbon dioxide and other waste gases. Multiple bags can be stacked together tightly, with o-ring spacers in between, and housed within a vessel to form a high-surface area, ultra-compact cell growing system. For cells growing on the bags, liquid nutrients can be fed by way of the tube spacers, and oxygen and waste gases permeated through the bag sides and transported within the bags.

The application provides a pH sensitive electrode of a wearable pH sensor for wound state diagnosis and application thereof. The electrode overcomes the problem of biological incompatibility defects of a conventional Ir-based electrode, realizes biological compatibility of the electrode sensitive material by introducing a biocompatible coating material to the surface of the Ir-based material, and solves the potential risk of application of the Ir-based pH sensor in a wearable application scenario.

The utility model provides a biocompatible coating preparation device, which relates to the technical field of biocompatible coating preparation and comprises a reactor, and an air inlet component is arranged on one side of the reactor. External chlorine is guided into the filter box through the gas inlet pipe, at the moment, fine impurities in the chlorine can be conveniently filtered through the filter plate, the cleanliness of the gas is guaranteed, moisture in the chlorine can be conveniently removed through the drying agent in the drying box so that the gas can be kept dry, the first valve is opened, and the purified chlorine enters the reactor to react; the problem that in the prior art, if introduced chlorine is not pure, the preparation effect is affected, and therefore the coating quality is affected is solved.

The invention relates to a vascular implantable brain-computer interface polymeric membrane material based on magnetosome targeted delivery as well as a preparation method and application of the vascular implantable brain-computer interface polymeric membrane material. The polymeric membrane material comprises a flexible polymeric basement membrane, a biocompatible coating and amination modified magnetosomes loaded on the surface of the coating, the basement membrane is composed of a blend of polycaprolactone and gelatin, and graphene nanosheets are dispersed in the basement membrane; the biocompatible coating is a compound of chitosan and hyaluronic acid; and the magnetosome is loaded on the surface of the coating through electrostatic interaction after amination treatment. The preparation method comprises the following steps: forming a basement membrane, constructing a biocompatible coating, and modifying and compounding the magnetosome. The vascular implantable brain-computer interface polymeric membrane material based on magnetosome targeted delivery can be used in a vascular implantable brain-computer interface targeted delivery system, delivery is carried out through a degradable packaging carrier in a vascular intervention mode, and targeted positioning of a brain target area is achieved under the action of an external magnetic field.

The utility model relates to the field of culture dishes, and discloses a culture dish capable of fixing Wharton's jelly, which comprises a culture dish body, the inner side wall of the culture dish body is sleeved with a biocompatible coating, and the centers of the two side walls of the culture dish body are respectively provided with a movable support. According to the utility model, the frame, the movable groove, the movable block, the handle and the movable support of the clamping groove are arranged, and the clamping block is connected with the screen, so that the culture can be conveniently screened and separated, the operability and the flexibility of the experiment are improved, and the aperture of the screen is set to be 100 microns, so that cells, particles or other substances with specific sizes can be accurately screened out; according to the present invention, with the application of the biocompatible coating, the accurate separation effect is provided for the experiment or treatment process, the requirements of the specific experiment or application are met, the biocompatible coating is adopted, and the coating material is collagen, such that the beneficial environment is provided for the adhesion and the growth of the cells, the cell damage and the adverse reaction can be reduced, and the cell culture effect and the cell culture quality can be significantly improved.

This invention discloses a method for integrating and optimizing the arterial filtration function of a membrane oxygenator, relating to the field of membrane oxygenator technology. The method includes the following steps: setting performance target parameters for an integrated membrane oxygenator; using a dynamic tension control process to wind gas exchange membrane fibers around its periphery to construct a temperature-changing unit and an oxygenation unit; during the winding process in step S2, placing multi-layer filter screens at preset positions to construct multi-layer filter screens between the gas exchange membrane fiber layers; using a centrifugal potting process to inject encapsulation material into the end of the component, curing it in one step to form a sealed end that isolates the blood phase, gas phase, and water phase; introducing a biomimetic coating solution into the molded blood channel to construct a biocompatible coating on the substrate surface; performing performance tests on the finished product and comparing it with the performance target parameters in S1; adjusting the process parameters of at least one step from S2 to S5 based on deviation feedback until the product meets the standards; this invention ensures the consistency and compliance rate of product performance.

The invention relates to a heterogeneous coaxial optical cable for minimally invasive surgery, which comprises a sheath and a cable core, the sheath comprises a first outer sheath, the cable core is located in the first outer sheath, the cable core comprises a laser transmission optical fiber and at least one functional element, and the functional element is an imaging optical fiber or a memory metal support rod; coating materials of the laser transmission optical fiber and the imaging optical fiber are polyacrylic resin, silicon resin or polyimide. According to the heterogeneous coaxial optical cable for minimally invasive surgery provided by the embodiment of the invention, the laser transmission optical fiber is arranged in the first outer sheath to provide intermediate infrared laser, the surface of the optical fiber is coated with the biocompatible coating, and the material can be polyacrylic resin, silicon resin and polyimide, so that the problems that the existing optical fiber coating is easy to hydrolyze and embrittle after being sterilized, and the service life of the optical fiber is prolonged can be solved. And the mechanical strength of the optical fiber is attenuated due to catalytic corrosion of the optical fiber caused by permeation of acid-base body fluid.

Devices and methods for encapsulating a portion of a wound dressing with biocompatible coating are disclosed. In some embodiments, a method includes applying a first coating on a first side of a flexible substrate of the wound dressing. The first side of the substrate can support a plurality of electronic components, electronic tracks, and connectors between the electronic components and electronic tracks. The first coating can be applied to at least one connectors. The application of the first coating can strengthen the at least one connector. The method can further include applying a second biocompatible coating on the first side of the substrate of the wound dressing and coating a second side of the substrate opposite the first side with a third coating, and coating at least some of the plurality of the electronic components with a fourth coating.

The invention belongs to the technical field of hydrocephalus operation equipment, and particularly relates to a cerebrospinal fluid shunting device. According to the flow dividing device, the biocompatible coating is arranged on the expansion support, and the biocompatible coating has the water absorption expansion characteristic, so that the weight of the coating after water absorption is increased, and under the limiting effect of the gravity of the biocompatible coating after water absorption, the expansion support is prevented from further expanding; the water-absorbing biocompatible coating enables the expansion stent to be clung to the blood vessel wall at the brain pool as much as possible, so that the volume of the expanded expansion stent is reduced, the expansion of the expansion stent and the water-absorbing weight of the biocompatible coating are relatively balanced, the volume of the subarachnoid space where the expansion stent is located cannot be excessively increased, and the expansion stent is more stable in expansion. Therefore, the risk of injury to a central nervous system caused by surgical operation and a shunting device is reduced.

This invention discloses a method for regulating β-amyloid protein aggregation based on circularly polarized light and its application. The method includes electrostatically binding an amino-modified upconversion luminescent nanoparticle to a SiO2-coated chiral optically active nanostructure to obtain an upconversion chiral nanomaterial; coating the surface of the upconversion chiral nanomaterial with a biocompatible coating and a brain-targeting ligand, then mixing it with β-amyloid protein, and targeting the region with 5–100 mW / cm² light. 2 Irradiation with an 800–1400 nm laser for 15–30 min excites upconversion chiral nanomaterials to emit circularly polarized light. This circularly polarized light inhibits the aggregation of β-amyloid protein by interfering with the formation of its β-sheet conformation. This invention utilizes circularly polarized light (CPL) to induce changes in key protein site interactions, thereby altering the conformation of protein aggregation. This process is reversible and highly spatially selective. Animal experiments have verified that this method can effectively block Aβ aggregation and improve cognitive function.