306 results about "Stratum corneum" patented technology

The invention provides an intelligent collaborative robot system for microneedle introduction, and relates to the technical field of medical puncture. The skin cuticle thickness, the surface roughness, the hue and other characteristic parameters are obtained through optical scanning and image processing technologies, and the initial puncture depth and the initial puncture frequency are predicted through a deep learning model; in the puncture process, skin humidity, impedance, tissue density and hue changes are monitored in real time, and a depth adjustment index and a frequency adjustment index are generated to adjust the initial puncture depth and the initial puncture frequency. According to the method, real-time sensing of the skin state and accurate regulation and control of puncture parameters are achieved, and the safety of microneedle treatment is remarkably improved.

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The invention relates to organoid culture. The invention provides a human epidermal organoid differential medium, a method for constructing an epidermal model and application of the human epidermal organoid differential medium, the human epidermal organoid differential medium comprises a basic medium component and an additive, and the additive comprises lipid. According to the method, the organoid is directly used for constructing the epidermal model, so that the problem of few cell sources is solved; a lipid component is added into the epidermal organ differentiation culture medium, so that the epidermal organ can enhance the barrier function of the cuticle, further differentiation of the epidermal organ can be effectively promoted by utilizing the epidermal organ differentiation culture medium, and a human epidermal model with a basal layer, a spinous layer, a granular layer and a cuticle which are completely morphologically differentiated is obtained. And the operation is simple, large-batch production is easy to realize, and a reliable tool is provided for in-vitro observation, interference of skin disease generation, injury repair and other life activities.

The invention relates to the technical field of medical education, in particular to a virtual patient skin care teaching system with enhanced pathological features and a method thereof, the system comprises pathological feature generation, parameter control, physical modeling, intelligent evaluation and a multi-mode feedback module, and can edit and simulate various skin pathological features in real time, such as pressure sores and diabetic feet, so that the system can be applied to the field of medical education. The visual display of the lesion degree is realized through a five-segment color mapping system, the system also simulates percolate reflection and cuticle spalling, the sense of reality is enhanced, the intelligent assessment module provides risk assessment and healing prediction according to physiological and morphological parameters, the multi-modal feedback module integrates visual sense, tactile sense and user behavior feedback, the interactive experience is improved, and the system is suitable for popularization and application. And the adaptive optimization module dynamically adjusts system parameters according to user feedback and learning effects, and provides personalized teaching. Compared with a traditional method, the method is higher in parameter control precision, supports personalized teaching, and is of great significance to medical education.

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention discloses an anti-aging face cream suitable for sensitive skin and a preparation method of the anti-aging face cream. The anti-aging face cream comprises 1-10 wt% of a supramolecular eutectic compound, 10-30 wt% of an auxiliary material and the balance of deionized water, the supramolecular eutectic compound comprises an anti-aging component, a supramolecular eutectic agent and Neosol-Aqulio, wherein the supramolecular eutectic agent is used for forming a supramolecular eutectic with the anti-aging component, and the Neosol-Aqulio is dispersed in the supramolecular eutectic; wherein the anti-aging component comprises oleuropein and hydroxytyrosol, and the supramolecular eutectic agent is nicotinamide, or a mixture of capryloyl glycine and betaine. Neosol-Aqulio, a supramolecular eutectic agent and an anti-aging component are utilized to form a supramolecular eutectic, so that active component delivery is facilitated, efficient transdermal absorption is realized, permeability, stability and mildness of the anti-aging active component are improved, the problem of sensitive skin cuticle permeation is solved, irritation of a traditional penetration enhancer is avoided, and the penetration enhancer is suitable for clinical application. The double effects of efficient permeation and mild anti-aging are realized.

The invention relates to the technical field of cosmetics, and particularly discloses a composition with long-acting moisturizing and repairing effects and application thereof. The composition is prepared from radix gentianae macrophyllae extract, mussel extract, leontopodium alpinum flower / leaf extract and rhizoma anemarrhenae root extract according to the mass ratio of 1: (0.5 to 1.5): (0.7 to 0.9): (0.1 to 0.3). According to the composition, through a multi-path synergistic effect, the gentiana macrophylla extract reduces water loss, the mussel extract constructs a dermis water storage network, the leontopodium alpinum extract enhances water locking and barrier repairing, and the rhizoma anemarrhenae root extract improves the water content of a cuticle. Experiments show that the gentiana macrophylla extract, the mussel extract, the leontopodium alpinum flower / leaf extract and the rhizoma anemarrhenae root extract are combined according to the mass ratio of 1: 1: 0.8: 0.2 for use, and the 8-hour moisturizing rate of the composition is as high as 79.69%. The composition can be added into cosmetics such as essence, emulsion and the like, and has high moisture retention, barrier repairing power and safety.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

Disclosed are a stretchable microneedle adhesive patch (SNAP) capable of performing high-quality electrophysiological (EP) signal measurement without skin preparation, such as exfoliating the skin or removing sweat, a SNAP system, and an operating method thereof. The disclosed SNAP capable of performing skin preparation-free high-quality EP signal measurement includes an electrically conductive adhesive (ECA) layer configured to attach to a user's skin to obtain an EP signal regardless of the user's skin condition; a microneedle sensor including a microneedle array configured to penetrate the stratum corneum by passing through the ECA layer and to directly contact the skin epidermis of the user; and conductive wire-based stretchable interconnects having a serpentine structure that is electrically and mechanically connected to the microneedle sensor to dynamically adapt to skin deformation of the user.

The invention relates to a whitening and repairing composition containing PDRN and polypeptide and application of the whitening and repairing composition. The composition comprises sodium hyaluronate, PDRN, polypeptide, vitamin C and cane sugar. Sodium hyaluronate, nucleic acid and polypeptide are adopted, so that the activity of collagen in the skin is enhanced, the moisture of cuticle and the integrity of a fiber structure are kept, the content of melanin in the epidermis is reduced, the skin barrier is repaired, the skin blood circulation is improved, anti-oxidation and anti-inflammatory treatment is performed, the skin color is brightened, and chromatosis is relieved, and sodium hyaluronate, nucleic acid and polypeptide are matched with one another; meanwhile, the release rate of nutritional ingredients is slowed down after the composition is injected into the skin, the action time is prolonged, and a better anti-degradation effect is achieved.

To provide a topical skin preparation that effectively promotes collagen production within the skin, exhibits excellent usability, and effectively enhances post-use stratum corneum moisture content.SOLUTION: A topical skin preparation comprises niacinamide, a heparin-like substance, dipotassium glycyrrhizinate, a collagen peptide, a yeast extract, and glycylglycine. It is preferable that the topical skin preparation further contains hydrogenated soybean phospholipids and phytosterols. It is more preferable that the topical skin preparation has a niacinamide content of 5 mass% or more. It is also preferable that the topical skin preparation further contains at least one plant extract selected from Arnica montana and Plantago major.SELECTED DRAWING: Figure 1

The invention relates to a preparation method of a biological membrane with a bionic cuticle'brick-slurry 'structure and a wound dressing application of the biological membrane, and belongs to the technical field of biological auxiliary materials. The preparation method comprises the following steps: dispersing prepared wool keratin microspheres in a fibroin solution, realizing a stable and firm brick-slurry structure by combining solvent volatilization with a photo-crosslinking technology, further crosslinking by utilizing metal ion coordination, and simultaneously endowing the dressing with the capabilities of effectively blocking bacterial permeation and sterilizing. The biological membrane exceeds the design of traditional layered wound dressings, and accurate reproduction of a natural skin structure is preferentially considered. The microspheres are assembled into a densely-arranged masonry structure material in a planned manner, so that the dressing has high moisture permeability, oxygen permeability and strong antibacterial barrier capacity, can promote repair of infectious wounds and burn and scald wounds, and has remarkable clinical application value.

The invention provides a composition for improving the permeation effect of a Campania maculata bark extract as well as a preparation method and application of the composition, and relates to the technical field of cosmetics. The invention provides an anti-aging composition for improving the permeation effect of a Campandra maculata bark extract. The anti-aging composition comprises recombinant human III type collagen, the Campandra maculata bark extract, an annona squamosa fruit extract, a Flos Magnoliae extract and a film-forming agent, the film-forming agent is composed of rhamnose and a trimethyl pentanediol / adipic acid / glycerol cross-linked polymer. The combination of the recombinant human III type collagen and the film-forming agent can strengthen hydration of cuticle, optimize the controlled release efficiency of active ingredients and broaden the permeation path, thereby forming an efficient permeation network from the skin surface to the deep layer. The combination of the Campandra mollissima bark extract, the Annona mollissima fruit extract and the Flos Magnoliae extract can construct a multi-dimensional antioxidant network, activate longevity proteins to resist saccharification and DNA damage, and comprehensively delay skin aging.

The invention discloses a medicine composition for treating atopic dermatitis, a preparation method and application, the medicine composition comprises inactivated malassezia sphaeroides, and the strain preservation number of the malassezia sphaeroides is ATCC 96807. The cream composition disclosed by the invention is externally applied to local treatment of skin lesions of specific dermatitis, supplements skin symbiotic bacteria, assists in recovering skin barriers of patients, remarkably inhibits growth and proliferation of staphylococcus aureus at the skin lesions of dermatitis and exocrine toxins, remarkably relieves inflammatory response, reduces the thickness of cuticles and reduces inflammatory cell infiltration; the traditional Chinese medicine composition assists the treatment of atopic dermatitis through the effects of the proinflammatory factors and the expression and secretion of the proinflammatory factors, has a remarkable treatment effect on the atopic dermatitis, is quick to take effect, small in toxic and side effects and good in safety, and has a good medicinal prospect.

The invention relates to the technical field of daily chemicals, in particular to a soothing composition as well as a preparation method and application thereof. The composition is prepared from saccharomycetes fermentation lysate filtrate, peony root extract, spanishneedles herb extract, liquorice root extract, glycerol and tremella fuciformis extract. Small molecule peptides in the fermentation lysate and flavone, polyphenol and triterpenoid components in the plant extract can inhibit inflammation pathways (such as TNF-alpha, IL-6 and COX-2) in a multi-target mode, and skin redness is effectively relieved. The skin barrier repairing capability is high: the tremella acidic polysaccharide and the yeast polypeptide form a synergistic network, so that the water content of a cuticle is favorably enhanced, and barrier lipid synthesis is promoted; a polysaccharide-polypeptide cross-linked chain structure is broken through a high-shear homogenizing treatment technology, so that the wiredrawing and colloid decorous feeling of a finished product are remarkably reduced, and a refreshing skin feeling is obtained.

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

To provide an estimation method for estimating the amount of marker proteins in the stratum corneum. [Solution] Identify one or more cell regions, stratified exfoliation regions, and single-cell regions in the stratum corneum image. A marker protein quantity estimation method that estimates the amount of marker proteins in the stratum corneum from stratum corneum images based on the correlation between the obtained stratum corneum parameters as explanatory variables and one of the following as the dependent variable: Enolase-1 quantity, FABP5 quantity, or Polyamine quantity.

This invention provides a 3D-printed hollow microneedle array resin patch, its preparation and application, a continuous glucose monitoring device, and a method for dynamic monitoring of blood glucose concentration, belonging to the field of biomedical technology. The hollow microneedle array resin patch of this invention features a "well"-shaped support to ensure the porosity of the perforated microneedles; the design of a hollow conical side opening greatly improves the porosity and microneedle pore volume, effectively increasing the amount of body fluid collected and thus improving detection accuracy. Based on 3D printing technology, the 3D-printed hollow microneedle array resin patch of this invention allows for the determination of basic parameters according to the diameter and height of existing needle sensors, as well as the depth of the stratum corneum and pain nerves, thereby achieving customization of the hollow microneedle combined with the needle sensor structure. It is suitable for needle sensors of different sizes, providing feasibility for microneedles to penetrate subcutaneously for biomarker detection.

The invention relates to the technical field of cosmetics, and discloses a herbal probiotic composition with whitening and anti-aging effects and a preparation method thereof. The herbal probiotic composition is prepared from alpha-arbutin, licoflavone, bakuchiol, resveratrol, ellagic acid, a metagen complex, skin micro-ecological prebiotics, sodium phytate, ferulic acid, rosemary polyphenol, polycystic liposome and the balance of a carrier suitable for skin. The herbal probiotic composition disclosed by the invention realizes stable co-delivery of hydrophilic and lipophilic activities and effective retention of cuticles under mild pH, synergistically inhibits blackness, resists oxidation and supports microecology, and improves the effective content and batch-to-batch consistency in the shelf life through metal ion accessibility control, so that the whitening and anti-aging effects are improved.

The invention discloses a swelling microneedle patch and a preparation method thereof. The swelling microneedle patch comprises a backing and a swelling microneedle array adhered to the backing, the swelling microneedle array comprises a plurality of microneedles; the microneedle is in the shape of a cone or a rectangular pyramid; the height of the microneedle is 100 to 1000 [mu] m; the diameter of the tip end of the microneedle is 5-30 microns; the diameter of the bottom of the microneedle is 50-500 [mu] m; and the center-to-center distance between every two adjacent microneedles is 50-2000 microns. The swelling microneedle patch provided by the invention can overcome the barrier action of cuticle to penetrate subcutaneously and absorb subcutaneous tissue interstitial fluid, and is simple in preparation process, low in cost and high in universality. The patch is combined with a colloidal gold lateral chromatography test strip, so that the limitations that in-vitro diagnosis of infectious diseases depends on a blood sample, professional medical personnel are needed for operation, the subject compliance is poor and the like can be solved, and the patch is suitable for rapid screening and diagnosis of the infectious diseases.

The invention discloses a scalp repair composition as well as a preparation method and application thereof. The scalp repair composition comprises sericin, ceramide NP, a purslane extract, polysorbate-20 and a water-phase matrix, the sericin and the ceramide NP are compounded to simulate a natural scalp cuticle structure, and barrier reconstruction is facilitated; the purslane extract is used for relieving pruritus and erythema in the repairing process; the pH value of the composition is 5.0-5.8, so that the composition is more suitable for the weakly acidic microenvironment of the scalp, and the irritation is effectively reduced. The composition can be applied to scalp repair essence, anti-hair loss products and medical auxiliary dressings, and has good safety and repair efficacy.

The invention discloses an efficient water-locking repair mask and a preparation method thereof, and belongs to the technical field of cosmetics, the efficient water-locking repair mask comprises the following components by mass: 0.5-2.0% of an astragalus membranacus extract fermentation broth, 0.1-0.5% of ceramide NP, 0.05-0.3% of a sodium hyaluronate composition, 0.1-0.3% of polyquaternium-51, 1-3% of a lactobacillus plantarum fermentation lysate, 1-5% of ethanol, and the balance of deionized water. The lactobacillus plantarum fermentation lysate comprises propionic acid and butyric acid. The Astragalus membranacus extract fermentation broth can remove allergic components and form a lipid-polysaccharide interpenetrating network with ceramide NP, and the Astragalus membranacus extract fermentation broth and ceramide NP synergistically simulate a natural barrier structure of skin, so that the order degree of cuticle lipid is improved, transdermal moisture loss is prevented, and the repairing and water locking functions are remarkably enhanced; butyric acid and propionic acid in the lactobacillus plantarum fermentation lysate promote penetration of ceramide NP by acidifying a cuticle microenvironment (pH 4.5), and the biological safety is high.

The invention discloses a stratum corneum moisture characteristic spectrum construction method and system based on hyperspectral imaging, and relates to the technical field of spectral data processing, and the method comprises the steps: collecting hyperspectral image data of to-be-detected skin; measuring the cuticle thickness of the skin to be measured by using an optical coherence tomography technology; obtaining a correlation coefficient between the percutaneous moisture loss rate of the to-be-detected skin and a stratum corneum scattering coefficient; and calculating and extracting a moisture absorption peak and generating a characteristic spectrum based on a K-M equation in combination with the cuticle thickness and the correlation coefficient. The cuticle thickness is obtained through an optical coherence tomography technology, the influence of the cuticle thickness on a spectrum model is corrected according to a K-M method based on the cuticle thickness, in addition, the incidence relation between TEWL and a cuticle scattering coefficient is established, therefore, correction parameters are provided for each detection in the later period, and an accurate cuticle moisture characteristic spectrum is generated. And the accuracy of the detection result of the water content of the cuticle is greatly improved.

This invention provides tranexamic acid liposomes, their preparation method, and applications, relating to the field of nanoliposome technology. This invention utilizes a simple process to prepare tranexamic acid liposomes by rationally combining the ratios of tranexamic acid, phospholipids, and cholesterol. This invention achieves high loading capacity and high loading rate for the active ingredient tranexamic acid, maintaining its stability for a long time under various temperature conditions. The tranexamic acid liposomes prepared by this invention have a particle size between 10-50 nm, enabling better penetration into the stratum corneum and targeting the basal layer of the skin, providing a long-lasting and stable effect. Compared to liposomes prepared by other processes, they exhibit excellent transdermal permeability and skin retention, which is more conducive to the efficacy of the active ingredient, significantly improving its bioavailability and resulting in a greater skin-lightening effect.

The invention belongs to the field of biomedical materials, and particularly relates to a soluble microneedle loaded with an artificial platelet exosome and polyphenol as well as a preparation method and application of the soluble microneedle. The microneedle comprises a back lining loaded with polyphenol and a needle body which is positioned on the back lining and is formed by compounding a soluble high-molecular polymer with an artificial platelet exosome and a protein protective agent. The soluble microneedle loaded with the artificial platelet exosome and the polyphenol can be used in the fields of alopecia, wound healing and the like, and growth factors rich in the platelet exosome can promote hair follicle regeneration, wound healing and the like. Artificial platelet exosome, polyphenol and a high-molecular polymer are compounded to prepare the soluble microneedle with enough hardness, the soluble microneedle can effectively pierce the cuticle of the skin surface layer, the needle body entering the skin can achieve rapid dissolution, active substances such as growth factors are guided into the dermis layer of the skin through the microneedle, and the microneedle is good in absorption effect, safe, reliable and free of side effects.

The invention discloses oil gel based on hermetia illucens oil as well as a preparation method and application of the oil gel, and relates to the technical field of biological medicines. According to the oil gel based on the hermetia illucens oil, the hermetia illucens oil is used as a grease matrix, and a stable lipid network structure is constructed by combining monoglyceride from hermetia illucens and vegetable wax. The hermetia illucens oil is derived from an animal lipid metabolism system, the fatty acid chain length distribution, the polarity characteristic and other aspects of the hermetia illucens oil are highly similar to those of a human skin cuticle lipid system, a continuous lipid covering layer can be formed on the surface of a burn wound, and the wound barrier condition is effectively improved; meanwhile, antioxidant fat-soluble components contained in the hermetia illucens oil are beneficial to reducing the local oxidative stress level of the wound surface and improving the microenvironment of the wound surface. The oleogel provided by the invention is suitable for external nursing of burn wounds, has dual functions of bionic barrier construction and antioxidant synergistic regulation, and can provide a novel and efficient biomedical material for burn wound repair.

The invention discloses directional traditional Chinese medicine transdermal application equipment, and relates to the technical field of biomedical engineering industries, the directional traditional Chinese medicine transdermal application equipment comprises a transdermal application part, the transdermal application part comprises an administration part and an application assembly, and the administration part presses and conveys medicine to the application assembly; the application assembly comprises a middle plate and a plurality of pyramid-shaped silica gel micro-protrusions which are arranged on the surface of the middle plate and distributed in an array mode, the up-down telescopic component stretches out and draws back to transmit force to the drug delivery component so that the silica gel micro-protrusions can be pressed to be tightly attached to the surface layer of the skin, and through the tip pressure gradient design of the silica gel micro-protrusions, the application effect is good on the premise that the completeness of the skin is not damaged. A cuticle lipid bilayer is promoted to generate reversible shear slippage, a loose pore channel with gradient pore diameter distribution is formed, pore diameters capable of directionally introducing the medicine are formed, and compared with a traditional plaster, the transdermal efficiency of the medicine is improved by multiple times; compared with a microneedle technology, the risk of dermis injury is avoided, and zero-wound drug delivery is achieved.

The invention relates to a traditional Chinese medicine external preparation for treating scalp inflammation. The traditional Chinese medicine external preparation is prepared from honeysuckle, radix sophorae flavescentis, fructus kochiae, cortex dictamni, dandelion, radix salviae miltiorrhizae, menthol, borneol and a transdermal enhancer. The preparation plays anti-inflammatory, bacteriostatic and barrier repairing roles through a multi-target synergistic mechanism, and is suitable for scalp inflammatory diseases such as seborrheic dermatitis and contact dermatitis. The preparation maximally retains active ingredients by adopting a specific extraction process, and the transdermal efficiency is improved by combining a triple permeation enhancing technology. The active ingredients reach the treatment concentration in the deep hair follicle. The pH value (5.5-6.0) of the preparation is matched with the weak acid environment of scalp, malassezia is selectively inhibited without damaging effective microbial communities, and the recurrence risk is reduced from the source. A spray, a lotion and a gel are proved to be capable of remarkably relieving erythema pruritus, inhibiting pathogenic bacteria colonization and accelerating cuticle repair, and have no skin irritation.

The invention discloses a traditional Chinese medicine skin chemical stripping reagent and a preparation method thereof. The reagent comprises a saturated potassium hydroxide solution, glutinous rice, gallnut, glycerol and a centella asiatica extract which form a functional formula based on the compatibility principle of monarch, minister, assistant and guide. The preparation method comprises the steps of weighing, crushing, multi-stage stirring, filtering and cooling, closed packaging and the like, and is clear in process parameters and clear in operation path. The reagent is suitable for removing cuticles, the using method comprises dispensing, standing and flushing, the whole stripping process is mild, and the adaptability is high. Compared with traditional tartaric acid and salicylic acid exfoliating agents, the reagent is low in irritation, natural in structure and stable in formula, has the dual functions of exfoliating, repairing and conditioning, is suitable for improving various pigment increase type skin diseases, and has a good treatment effect on lesions located at the positions difficult to operate such as the nose, the lip periphery and the eye periphery. The technical scheme has good safety, ingredient controllability and popularization prospect, and is suitable for being used in the fields of orthopaedic surgery and dermatology department.