367 results about "Stratum corneum" patented technology

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

The invention provides an intelligent collaborative robot system for microneedle introduction, and relates to the technical field of medical puncture. The skin cuticle thickness, the surface roughness, the hue and other characteristic parameters are obtained through optical scanning and image processing technologies, and the initial puncture depth and the initial puncture frequency are predicted through a deep learning model; in the puncture process, skin humidity, impedance, tissue density and hue changes are monitored in real time, and a depth adjustment index and a frequency adjustment index are generated to adjust the initial puncture depth and the initial puncture frequency. According to the method, real-time sensing of the skin state and accurate regulation and control of puncture parameters are achieved, and the safety of microneedle treatment is remarkably improved.

The invention relates to the technical field of medical materials, and particularly discloses a biocompatible hydrogel microneedle nursing dressing and a preparation method thereof. A biocompatible hydrogel microneedle nursing dressing comprises a hydrogel substrate, microneedles regularly attached to the side, facing the skin, of the hydrogel substrate, and a breathable film layer attached to the side, back to the skin, of the hydrogel substrate. The micro-needle array tip area of the biocompatible hydrogel micro-needle nursing dressing provides rigid support through silk fibroin, it is ensured that a micro-needle can penetrate through the cuticle, the silk fibroin and hyaluronic acid are compounded through the middle-layer needle body transition area, the mechanical strength and the swelling property are balanced, the flexibility is improved through glycerinum, the needle body is prevented from being broken, and the biocompatibility is improved. The closed area of the top substrate adopts high-concentration hyaluronic acid to achieve rapid water absorption swelling and promote drug diffusion, polydopamine nanoparticles enhance antibacterial property and tissue adhesion, genipin crosslinking improves mechanical strength, and a sealing barrier is formed to prevent drug leakage.

The invention relates to organoid culture. The invention provides a human epidermal organoid differential medium, a method for constructing an epidermal model and application of the human epidermal organoid differential medium, the human epidermal organoid differential medium comprises a basic medium component and an additive, and the additive comprises lipid. According to the method, the organoid is directly used for constructing the epidermal model, so that the problem of few cell sources is solved; a lipid component is added into the epidermal organ differentiation culture medium, so that the epidermal organ can enhance the barrier function of the cuticle, further differentiation of the epidermal organ can be effectively promoted by utilizing the epidermal organ differentiation culture medium, and a human epidermal model with a basal layer, a spinous layer, a granular layer and a cuticle which are completely morphologically differentiated is obtained. And the operation is simple, large-batch production is easy to realize, and a reliable tool is provided for in-vitro observation, interference of skin disease generation, injury repair and other life activities.

The present invention discloses a probiotic postbiotic composition for improving the scalp environment, a preparation method thereof and an application thereof, wherein the probiotic postbiotic composition for improving the scalp environment comprises postbiotics obtained by fermenting two strains of Lactobacillus paracasei ProSci-101 and Lactobacillus fermentum ProSci-602; the Lactobacillus paracasei ProSci-101 has a preservation number of CGMCC No.26528; the Lactobacillus fermentum ProSci-602 has a preservation number of CGMCC NO.25451. The probiotic postbiotic composition for improving the scalp environment of the present invention has the effects of cell repair, enhancing elastin and renewing the metabolism of the dermis, can slow down cell aging, and promote the proliferation of stratum corneum cells; thereby effectively achieving the purpose of improving the scalp environment and preventing hair loss.

The invention relates to the technical field of medical education, in particular to a virtual patient skin care teaching system with enhanced pathological features and a method thereof, the system comprises pathological feature generation, parameter control, physical modeling, intelligent evaluation and a multi-mode feedback module, and can edit and simulate various skin pathological features in real time, such as pressure sores and diabetic feet, so that the system can be applied to the field of medical education. The visual display of the lesion degree is realized through a five-segment color mapping system, the system also simulates percolate reflection and cuticle spalling, the sense of reality is enhanced, the intelligent assessment module provides risk assessment and healing prediction according to physiological and morphological parameters, the multi-modal feedback module integrates visual sense, tactile sense and user behavior feedback, the interactive experience is improved, and the system is suitable for popularization and application. And the adaptive optimization module dynamically adjusts system parameters according to user feedback and learning effects, and provides personalized teaching. Compared with a traditional method, the method is higher in parameter control precision, supports personalized teaching, and is of great significance to medical education.

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention discloses glycerin entrapped with recombinant human collagen III and a preparation method and application thereof, and belongs to the technical field of medicines and cosmetics, the glycerin entrapped with recombinant human collagen III comprises phospholipid, glycerin, Tween 80, chitosan quaternary ammonium salt, sodium hyaluronate, recombinant human collagen III and a PBS buffer solution. Glycerin which has high deformation performance and can effectively penetrate through the stratum corneum is prepared, and double-layer modification of chitosan quaternary ammonium salt and sodium hyaluronate is carried out on the glycerol to deliver the recombinant human-derived III-type collagen, so that the problems that the recombinant human-derived III-type collagen is high in hydrophilicity, large in molecular weight and difficult to penetrate through the stratum corneum of the skin can be effectively solved; the bioavailability and the percutaneous penetration of the recombinant human III type collagen are obviously improved.

The invention discloses an anti-aging face cream suitable for sensitive skin and a preparation method of the anti-aging face cream. The anti-aging face cream comprises 1-10 wt% of a supramolecular eutectic compound, 10-30 wt% of an auxiliary material and the balance of deionized water, the supramolecular eutectic compound comprises an anti-aging component, a supramolecular eutectic agent and Neosol-Aqulio, wherein the supramolecular eutectic agent is used for forming a supramolecular eutectic with the anti-aging component, and the Neosol-Aqulio is dispersed in the supramolecular eutectic; wherein the anti-aging component comprises oleuropein and hydroxytyrosol, and the supramolecular eutectic agent is nicotinamide, or a mixture of capryloyl glycine and betaine. Neosol-Aqulio, a supramolecular eutectic agent and an anti-aging component are utilized to form a supramolecular eutectic, so that active component delivery is facilitated, efficient transdermal absorption is realized, permeability, stability and mildness of the anti-aging active component are improved, the problem of sensitive skin cuticle permeation is solved, irritation of a traditional penetration enhancer is avoided, and the penetration enhancer is suitable for clinical application. The double effects of efficient permeation and mild anti-aging are realized.

The purpose of the present invention is to promote diffusion of an active component contained in a supplied liquid agent under a surface layer, using a compact configuration.　A diffusion promotion device (100) comprises a first cylindrical member (110) and a second cylindrical member (120). In a state in which a liquid agent has been or is being supplied to an object from a liquid agent supply unit (220) of a liquid agent supply device (200) accommodated in an internal accommodation space of the diffusion promotion device (100), when a current path is formed between a first electrode (1151 and / or 1152) formed on a side surface of the first cylindrical member (110) and a second electrode (125) formed on a tip end portion of the second cylindrical member (120) through a surface layer portion of the object, diffusion of an active component contained in the liquid agent under the surface layer of the object (for example, the surface or stratum corneum of the skin of a person) is promoted. That is, the diffusion promotion device (100) promotes diffusion of the active ingredient under the surface layer of the object by an ion introduction effect.

The present invention addresses the problem of providing an improving agent for improving a stratum corneum barrier function without external replenishment with any moisturizing substance and a pharmaceutical composition containing said improving agent. The present invention provides: a stratum corneum barrier function improving agent which contains a glycolytic inhibitor as an active ingredient; the stratum corneum barrier function improving agent in which the glycolytic inhibitor is at least one selected from the group consisting of a glucose transporter inhibitor and a glucose competitive inhibitor; either of said stratum corneum barrier function improving agents having at least one selected from the group consisting of an inhibitory effect on the loss of skin moisture retention capacity and an inhibitory effect on skin permeability enhancement; and a pharmaceutical composition which contains any of said stratum corneum barrier function improving agents.

A biosynthesis method for preparing royal jelly acid and the use thereof in skin care, which belong to the technical field of genetic engineering and biosynthesis. The royal jelly acid is produced by means of fermentation on the basis of yeast engineering bacteria using a culture medium containing trans-2-decenoic acid. An assessment at both skin cell level and skin model level shows that royal jelly acid can promote the synthesis of stratum corneum lipids and ceramide on aging skin and repair the skin barrier; and also can promote the synthesis of mitochondria ATP and NADPH in skin fibroblasts, reduce the active oxygen content of mitochondria, improve mitochondrial dysfunctions, and inhibit apoptosis. Further experiments show that royal jelly acid can repair DNA damage of fibroblasts caused by ultraviolet irradiation, reduce telomere shortening caused by cell division and replication, and strengthen the protection of chromosomal terminal regions. The prepared royal jelly acid has wide application prospects in the development of functional skin care products for skin repairing, aging resisting, etc.

The invention discloses a construction method and application of a caenorhabditis elegans inflammation model, belongs to the technical field of model biology, and provides a construction method of a caenorhabditis elegans inflammation model, which comprises the following steps: putting L1-stage caenorhabditis elegans into a lipopolysaccharide solution, and carrying out induced culture to obtain induced cultured caenorhabditis elegans; placing the caenorhabditis elegans in a chromosome system, performing staining culture and centrifugation to obtain dyed caenorhabditis elegans, and placing the dyed caenorhabditis elegans on a culture medium for recovery to obtain the caenorhabditis The surface of the caenorhabditis elegans is provided with a transparent cuticle anatomical structure, the intestinal barrier damage condition is easy to observe after the intestinal tract is dyed by a dye, and the cell proliferation, tissue development and tissue integrity of the caenorhabditis elegans are easy to carry out fluorescence microscope and morphological analysis. A caenorhabditis elegans inflammation model is constructed through lipopolysaccharide induction, and a new experimental animal model is provided for screening anti-inflammatory drugs.

The invention discloses an acne-removing essence and a preparation method thereof, and particularly relates to the technical field of skin care products, the acne-removing essence comprises the following components by mass: 0.5-5% of salicylic acid; 1%-5% of tartaric acid; 2%-6% of nicotinamide; 0.5%-2% of colloidal sulfur; 1.5%-3% of tea tree essential oil; 1%-2% of hyaluronic acid; 0.5%-1% of ceramide; 1%-3% of glycerol; 1%-2% of trehalose; the salicylic acid is used for penetrating into skin, helping to relieve dead skin cells, reducing inflammation and accelerating skin renewal; the tartaric acid is used for realizing a stripping effect, can remove aged cuticles on the surface of the skin and promote the generation of new cells, so that the problem of acnes is helped to be improved. The acne-removing essence prepared by the invention has a relatively good moisturizing effect, so that skin barrier can be well maintained, keratin metabolism is promoted, grease secretion is inhibited, acne is effectively prevented, inflammatory response of the acne is relieved, and the actual use effect of the acne-removing essence is relatively good.

The invention relates to the technical field of cosmetics, and particularly discloses a composition with long-acting moisturizing and repairing effects and application thereof. The composition is prepared from radix gentianae macrophyllae extract, mussel extract, leontopodium alpinum flower / leaf extract and rhizoma anemarrhenae root extract according to the mass ratio of 1: (0.5 to 1.5): (0.7 to 0.9): (0.1 to 0.3). According to the composition, through a multi-path synergistic effect, the gentiana macrophylla extract reduces water loss, the mussel extract constructs a dermis water storage network, the leontopodium alpinum extract enhances water locking and barrier repairing, and the rhizoma anemarrhenae root extract improves the water content of a cuticle. Experiments show that the gentiana macrophylla extract, the mussel extract, the leontopodium alpinum flower / leaf extract and the rhizoma anemarrhenae root extract are combined according to the mass ratio of 1: 1: 0.8: 0.2 for use, and the 8-hour moisturizing rate of the composition is as high as 79.69%. The composition can be added into cosmetics such as essence, emulsion and the like, and has high moisture retention, barrier repairing power and safety.

The invention provides a soothing composition and application thereof in cosmetics, the soothing composition is composed of LIPOCIRE A PELLETS, Ectoine, a centella asiatica extract, Symcalmin, a purslane extract and panthenol, the composition utilizes a non-soothing component LIPOCIRE A PELLETS to be combined with a plurality of soothing active components, the action effect of each soothing component is fully exerted, human body tests show that the soothing composition has the effect of relieving the pain of a human body, and the soothing composition has the effect of relieving the pain of the human body. The composition can significantly improve the water content of the skin cuticle, reduce the skin transdermal water loss rate and the skin color a * value, and has significant synergistic effects in improving the moisturizing, repairing, soothing and other aspects of the soothing components.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

Disclosed are a stretchable microneedle adhesive patch (SNAP) capable of performing high-quality electrophysiological (EP) signal measurement without skin preparation, such as exfoliating the skin or removing sweat, a SNAP system, and an operating method thereof. The disclosed SNAP capable of performing skin preparation-free high-quality EP signal measurement includes an electrically conductive adhesive (ECA) layer configured to attach to a user's skin to obtain an EP signal regardless of the user's skin condition; a microneedle sensor including a microneedle array configured to penetrate the stratum corneum by passing through the ECA layer and to directly contact the skin epidermis of the user; and conductive wire-based stretchable interconnects having a serpentine structure that is electrically and mechanically connected to the microneedle sensor to dynamically adapt to skin deformation of the user.

The invention relates to a whitening and repairing composition containing PDRN and polypeptide and application of the whitening and repairing composition. The composition comprises sodium hyaluronate, PDRN, polypeptide, vitamin C and cane sugar. Sodium hyaluronate, nucleic acid and polypeptide are adopted, so that the activity of collagen in the skin is enhanced, the moisture of cuticle and the integrity of a fiber structure are kept, the content of melanin in the epidermis is reduced, the skin barrier is repaired, the skin blood circulation is improved, anti-oxidation and anti-inflammatory treatment is performed, the skin color is brightened, and chromatosis is relieved, and sodium hyaluronate, nucleic acid and polypeptide are matched with one another; meanwhile, the release rate of nutritional ingredients is slowed down after the composition is injected into the skin, the action time is prolonged, and a better anti-degradation effect is achieved.

The invention relates to a decarboxylated carnosine derivative as well as a preparation method and application thereof. The structural formula of the decarboxylated carnosine derivative is shown as a formula (I), wherein R is selected from C5-C21 alkyl and C5-C21 unsaturated chain alkyl. Compared with decarboxylated carnosine, the decarboxylated carnosine derivative disclosed by the invention has a more excellent anti-saccharification effect; meanwhile, a relatively good anti-oxidation effect is achieved; moreover, the decarboxylated carnosine derivative disclosed by the invention has certain lipophilicity, is relatively easy to penetrate through a skin cuticle, is good in skin permeability and relatively good in stability, can be used for preparing cosmetics for resisting saccharification, resisting oxidation, resisting skin aging and the like, and has an important market value. # imgabs0 #

To provide a topical skin preparation that effectively promotes collagen production within the skin, exhibits excellent usability, and effectively enhances post-use stratum corneum moisture content.SOLUTION: A topical skin preparation comprises niacinamide, a heparin-like substance, dipotassium glycyrrhizinate, a collagen peptide, a yeast extract, and glycylglycine. It is preferable that the topical skin preparation further contains hydrogenated soybean phospholipids and phytosterols. It is more preferable that the topical skin preparation has a niacinamide content of 5 mass% or more. It is also preferable that the topical skin preparation further contains at least one plant extract selected from Arnica montana and Plantago major.SELECTED DRAWING: Figure 1

The invention relates to the technical field of cosmetics, in particular to a composition with a blackhead removing effect and application of the composition in the cosmetics, mandelic acid and salicylic acid in the composition can permeate deep pores to dissolve grease and cutin so as to achieve the effect of reducing formation of blackheads, tea tree essential oil can remove bacteria and dirt in the pores, and therefore the blackhead removing effect is achieved. Antibacterial and anti-inflammation effects can be realized on the basis of removing blackheads, pricking pain caused by skin allergy can be relieved by adding carboxymethyl yeast glucan, and moisturizing effects can be realized; the herba portulacae extract has the effects of resisting inflammation, resisting allergy and enhancing the skin immune function, when the herba portulacae extract is used in the composition with the blackhead removing effect, the effect of accelerating skin recovery can be achieved, and the D-panthenol has the effect of rapidly permeating into the skin cuticle and can stimulate the growth of epidermal cells so as to accelerate skin barrier repair after blackhead removing. And the chitosan-based gel is combined, so that the probability that the skin is irritated and allergic can be reduced.

The present invention relates to a soluble microneedle for local anesthesia and a local anesthesia patch comprising same, the soluble microneedle comprising an amide-based local anesthetic, hyaluronic acid, and polyvinylpyrrolidone in a specific content ratio. The present invention uses the soluble microneedle to implement direct drug delivery by physically permeating through the stratum corneum and mucosa, and thus a precise and rapid anesthetic effect may be exhibited. Especially, the microneedle comprising a specific amount of polyvinylpyrrolidone is dissolved, and the anesthetic contained in the microneedle is rapidly delivered to nerve cells, and thus the disadvantage of a long waiting time of conventional anesthetic creams may be overcome, and thus the present invention has the advantage of being usable in various ways in dental, dermatology, and other surgical procedures requiring local anesthesia.

The invention relates to a preparation method of a biological membrane with a bionic cuticle'brick-slurry 'structure and a wound dressing application of the biological membrane, and belongs to the technical field of biological auxiliary materials. The preparation method comprises the following steps: dispersing prepared wool keratin microspheres in a fibroin solution, realizing a stable and firm brick-slurry structure by combining solvent volatilization with a photo-crosslinking technology, further crosslinking by utilizing metal ion coordination, and simultaneously endowing the dressing with the capabilities of effectively blocking bacterial permeation and sterilizing. The biological membrane exceeds the design of traditional layered wound dressings, and accurate reproduction of a natural skin structure is preferentially considered. The microspheres are assembled into a densely-arranged masonry structure material in a planned manner, so that the dressing has high moisture permeability, oxygen permeability and strong antibacterial barrier capacity, can promote repair of infectious wounds and burn and scald wounds, and has remarkable clinical application value.

The invention provides a composition for improving the permeation effect of a Campania maculata bark extract as well as a preparation method and application of the composition, and relates to the technical field of cosmetics. The invention provides an anti-aging composition for improving the permeation effect of a Campandra maculata bark extract. The anti-aging composition comprises recombinant human III type collagen, the Campandra maculata bark extract, an annona squamosa fruit extract, a Flos Magnoliae extract and a film-forming agent, the film-forming agent is composed of rhamnose and a trimethyl pentanediol / adipic acid / glycerol cross-linked polymer. The combination of the recombinant human III type collagen and the film-forming agent can strengthen hydration of cuticle, optimize the controlled release efficiency of active ingredients and broaden the permeation path, thereby forming an efficient permeation network from the skin surface to the deep layer. The combination of the Campandra mollissima bark extract, the Annona mollissima fruit extract and the Flos Magnoliae extract can construct a multi-dimensional antioxidant network, activate longevity proteins to resist saccharification and DNA damage, and comprehensively delay skin aging.

The invention discloses a lactobacillus mucus CCFM1401 for repairing a skin barrier based on multiple target spots and a metagen of the lactobacillus mucus CCFM1401, and belongs to the technical field of microorganisms and medicines. The thallus lysate of the fermented lactobacillus mucus CCFM1401, provided by the invention, can be used for improving the cell viability of damaged keratinocytes and the expression of FLG, LOR, IVL, ZO-1, Occludin and CLDN gene levels in the aspect of external application; and viable bacteria and metabiotics (including thallus lysate and fermentation supernatant) of the fermented lactobacillus mucus CCFM1401 are orally taken, so that TEWL can be reduced, the water content of cuticle can be up-regulated, inflammatory reactions (such as skin histamine and serum IgE) can be reduced, and the skin barrier function and expression of structural protein can be up-regulated. Therefore, the fermented lactobacillus mucilaginosus has a huge application prospect in preparation of external or oral medicines for repairing the skin barrier and preparation of food, health care products or cosmetics.

The invention discloses a medicine composition for treating atopic dermatitis, a preparation method and application, the medicine composition comprises inactivated malassezia sphaeroides, and the strain preservation number of the malassezia sphaeroides is ATCC 96807. The cream composition disclosed by the invention is externally applied to local treatment of skin lesions of specific dermatitis, supplements skin symbiotic bacteria, assists in recovering skin barriers of patients, remarkably inhibits growth and proliferation of staphylococcus aureus at the skin lesions of dermatitis and exocrine toxins, remarkably relieves inflammatory response, reduces the thickness of cuticles and reduces inflammatory cell infiltration; the traditional Chinese medicine composition assists the treatment of atopic dermatitis through the effects of the proinflammatory factors and the expression and secretion of the proinflammatory factors, has a remarkable treatment effect on the atopic dermatitis, is quick to take effect, small in toxic and side effects and good in safety, and has a good medicinal prospect.

The invention relates to a sinomenine hydrochloride loaded chlorcosan polysaccharide microneedle as well as a preparation method and application thereof, and belongs to the technical field of sinomenine hydrochloride microneedles. The chlorpeas polysaccharide microneedle comprises a needle tip layer and a backing layer, the needle tip layer is prepared by performing primary drying on a mixed aqueous solution containing sinomenine hydrochloride and chlorpeas polysaccharide, and the backing layer is prepared by performing secondary drying on a chlorpeas polysaccharide aqueous solution. The sinomenine hydrochloride loaded Jingui bean polysaccharide microneedle has enough mechanical strength to penetrate through the stratum corneum, has biodegradability and good biocompatibility, is small in skin irritation, has good skin permeability and high drug loading capacity, and has flexibility and adhesion due to the fact that the microneedle is backed. When in use, the micro-needle can be tightly adhered to a movable joint part, so that dissolution is promoted, the insertion efficiency of the micro-needle is improved, and the stability of transdermal drug delivery is ensured.

The invention relates to the technical field of daily chemicals, in particular to a soothing composition as well as a preparation method and application thereof. The composition is prepared from saccharomycetes fermentation lysate filtrate, peony root extract, spanishneedles herb extract, liquorice root extract, glycerol and tremella fuciformis extract. Small molecule peptides in the fermentation lysate and flavone, polyphenol and triterpenoid components in the plant extract can inhibit inflammation pathways (such as TNF-alpha, IL-6 and COX-2) in a multi-target mode, and skin redness is effectively relieved. The skin barrier repairing capability is high: the tremella acidic polysaccharide and the yeast polypeptide form a synergistic network, so that the water content of a cuticle is favorably enhanced, and barrier lipid synthesis is promoted; a polysaccharide-polypeptide cross-linked chain structure is broken through a high-shear homogenizing treatment technology, so that the wiredrawing and colloid decorous feeling of a finished product are remarkably reduced, and a refreshing skin feeling is obtained.

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.