158 results about "Stratum corneum" patented technology

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention discloses a nano-enzyme microneedle system for remodeling a diabetes wound microenvironment to promote healing and a preparation method of the nano-enzyme microneedle system. The nano-enzyme microneedle system comprises nano-enzyme and a microneedle carrier, the nano-enzyme is prepared by a self-assembly method and is loaded in the microneedle carrier; the microneedle carrier is composed of a hydrogel matrix and is molded into a microneedle array through 3D printing; according to the system, the nano-enzyme can be delivered to the corium layer by penetrating the cuticle of the skin through the microneedle. The traditional Chinese medicine composition has the advantages that ROS (reactive oxygen species) is efficiently removed, oxidative stress injury induced by high glucose (HG) is relieved, immune cell polarization is regulated, inflammatory factor release is regulated and controlled, the chronic inflammation state of wound surfaces is relieved, cell proliferation and migration are promoted, neovascularization is accelerated, the healing speed of the diabetic wound surfaces is obviously increased, inflammation infiltration is reduced, granulation tissue formation and collagen deposition are obviously improved, and the effect of treating diabetes mellitus is achieved. And no systemic toxicity is observed. Through the synergistic effect of resisting oxidation, resisting inflammation and promoting angiogenesis, the pathological microenvironment of the diabetic wound is effectively improved.

The application provides a drying method of Chuanxiong medicinal material and application of Chuanxiong or its extract in preparation of an external medicine for treating atopic dermatitis. The drying method of Chuanxiong medicinal material improves Chuanxiong processing efficiency, shortens processing period, obtains by-product Chuanxiong extract in addition to preparation of decoction pieces, reduces energy consumption and lowers production cost. The Chuanxiong essential oil and Chuanxiong extract are both composed of small molecule components, have good affinity to skin, are absorbed through skin quickly, can quickly relieve symptoms such as itching and skin damage caused by atopic dermatitis, and are natural, safe and free of side effects. Meanwhile, the small molecule components contained in the Chuanxiong essential oil and Chuanxiong extract have good lipophilicity, have softening effect on the thickened stratum corneum caused by atopic dermatitis, and are more conducive to drug absorption. In addition, the Chuanxiong essential oil and Chuanxiong extract are simple to prepare and low in price.

The invention provides a hinokitiol-dihydromyricetin composite nano condensation body and a preparation method and application thereof, and the composite nano condensation body comprises the following components in 100 mL of a suspension: 0.3 to 0.5 g of hinokitiol, 0.5 to 0.8 g of dihydromyricetin, 1.0 to 1.5 g of chitosan, 0.5 to 0.8 g of sodium alginate, 2.0 to 3.0 mL of polyethylene glycol, 0.3 to 0.5 mL of Tween, 1.0 to 1.5 mL of glycerol, and the balance of a citric acid-sodium citrate buffer solution. The invention provides a hinokitiol-dihydromyricetin composite nano-coacervate which can synchronously solve the problems of synergistic bacteriostasis, membrane rupture and antibiosis, anti-inflammatory repair, application defects of active ingredients and the like of common animal skin antibacterial drugs. The preparation method of the composite nano coacervate is simple, large-scale production is easy, complex equipment is not needed, it can be ensured that active ingredients of a finished product are evenly distributed, the composite nano coacervate can penetrate through the skin cuticle and can also penetrate through a bacterial biofilm, and the synergistic effect is fully achieved.

To provide an estimation method for estimating the amount of marker proteins in the stratum corneum. [Solution] Identify one or more cell regions, stratified exfoliation regions, and single-cell regions in the stratum corneum image. A marker protein quantity estimation method that estimates the amount of marker proteins in the stratum corneum from stratum corneum images based on the correlation between the obtained stratum corneum parameters as explanatory variables and one of the following as the dependent variable: Enolase-1 quantity, FABP5 quantity, or Polyamine quantity.

This invention provides a 3D-printed hollow microneedle array resin patch, its preparation and application, a continuous glucose monitoring device, and a method for dynamic monitoring of blood glucose concentration, belonging to the field of biomedical technology. The hollow microneedle array resin patch of this invention features a "well"-shaped support to ensure the porosity of the perforated microneedles; the design of a hollow conical side opening greatly improves the porosity and microneedle pore volume, effectively increasing the amount of body fluid collected and thus improving detection accuracy. Based on 3D printing technology, the 3D-printed hollow microneedle array resin patch of this invention allows for the determination of basic parameters according to the diameter and height of existing needle sensors, as well as the depth of the stratum corneum and pain nerves, thereby achieving customization of the hollow microneedle combined with the needle sensor structure. It is suitable for needle sensors of different sizes, providing feasibility for microneedles to penetrate subcutaneously for biomarker detection.

The invention relates to the technical field of cosmetics, and discloses a herbal probiotic composition with whitening and anti-aging effects and a preparation method thereof. The herbal probiotic composition is prepared from alpha-arbutin, licoflavone, bakuchiol, resveratrol, ellagic acid, a metagen complex, skin micro-ecological prebiotics, sodium phytate, ferulic acid, rosemary polyphenol, polycystic liposome and the balance of a carrier suitable for skin. The herbal probiotic composition disclosed by the invention realizes stable co-delivery of hydrophilic and lipophilic activities and effective retention of cuticles under mild pH, synergistically inhibits blackness, resists oxidation and supports microecology, and improves the effective content and batch-to-batch consistency in the shelf life through metal ion accessibility control, so that the whitening and anti-aging effects are improved.

The invention discloses a swelling microneedle patch and a preparation method thereof. The swelling microneedle patch comprises a backing and a swelling microneedle array adhered to the backing, the swelling microneedle array comprises a plurality of microneedles; the microneedle is in the shape of a cone or a rectangular pyramid; the height of the microneedle is 100 to 1000 [mu] m; the diameter of the tip end of the microneedle is 5-30 microns; the diameter of the bottom of the microneedle is 50-500 [mu] m; and the center-to-center distance between every two adjacent microneedles is 50-2000 microns. The swelling microneedle patch provided by the invention can overcome the barrier action of cuticle to penetrate subcutaneously and absorb subcutaneous tissue interstitial fluid, and is simple in preparation process, low in cost and high in universality. The patch is combined with a colloidal gold lateral chromatography test strip, so that the limitations that in-vitro diagnosis of infectious diseases depends on a blood sample, professional medical personnel are needed for operation, the subject compliance is poor and the like can be solved, and the patch is suitable for rapid screening and diagnosis of the infectious diseases.

This invention provides tranexamic acid liposomes, their preparation method, and applications, relating to the field of nanoliposome technology. This invention utilizes a simple process to prepare tranexamic acid liposomes by rationally combining the ratios of tranexamic acid, phospholipids, and cholesterol. This invention achieves high loading capacity and high loading rate for the active ingredient tranexamic acid, maintaining its stability for a long time under various temperature conditions. The tranexamic acid liposomes prepared by this invention have a particle size between 10-50 nm, enabling better penetration into the stratum corneum and targeting the basal layer of the skin, providing a long-lasting and stable effect. Compared to liposomes prepared by other processes, they exhibit excellent transdermal permeability and skin retention, which is more conducive to the efficacy of the active ingredient, significantly improving its bioavailability and resulting in a greater skin-lightening effect.

The invention discloses oil gel based on hermetia illucens oil as well as a preparation method and application of the oil gel, and relates to the technical field of biological medicines. According to the oil gel based on the hermetia illucens oil, the hermetia illucens oil is used as a grease matrix, and a stable lipid network structure is constructed by combining monoglyceride from hermetia illucens and vegetable wax. The hermetia illucens oil is derived from an animal lipid metabolism system, the fatty acid chain length distribution, the polarity characteristic and other aspects of the hermetia illucens oil are highly similar to those of a human skin cuticle lipid system, a continuous lipid covering layer can be formed on the surface of a burn wound, and the wound barrier condition is effectively improved; meanwhile, antioxidant fat-soluble components contained in the hermetia illucens oil are beneficial to reducing the local oxidative stress level of the wound surface and improving the microenvironment of the wound surface. The oleogel provided by the invention is suitable for external nursing of burn wounds, has dual functions of bionic barrier construction and antioxidant synergistic regulation, and can provide a novel and efficient biomedical material for burn wound repair.

The invention provides a medical beauty-grade sensitive skin repair dressing with a gamma-polyglutamic acid controlled release function, and belongs to the technical field of biomedical materials. The repair dressing is composed of controlled release microspheres dispersed in a matrix material, the controlled release microspheres take modified gamma-polyglutamic acid as an active core material and a biocompatible high polymer material as a wall material, and the matrix material comprises a medical grade gel matrix, a moisturizing component and an anti-inflammatory soothing component. The gamma-polyglutamic acid is subjected to acylation or graft modification to improve the stability and biocompatibility of the gamma-polyglutamic acid, and 12-72h gradient release of the gamma-polyglutamic acid is realized by virtue of the controlled release microspheres prepared by virtue of an emulsification-crosslinking method or a solvent evaporation method; meanwhile, through the synergistic matching of the matrix components, the dressing is endowed with the moisturizing, anti-inflammatory and soothing effects. The dressing can effectively reduce wound inflammatory response after medical art, promote epidermal cell proliferation and improve the water content and barrier function of a sensitive skin cuticle, and is suitable for scenes of wound repair after medical art, sensitive skin barrier reconstruction and the like.

The invention belongs to the technical field of biological medicine, and particularly relates to a formula and application of a microcrystal patch containing polysulfonic acid mucopolysaccharide. The microcrystal patch disclosed by the invention is prepared from the following components in percentage by mass: 96 to 97 percent of purified water, 0.6 percent of polyvinyl alcohol, 1 to 2 percent of sodium hyaluronate with the molecular weight of 50,000 to 10,000, 0.6 to 1 percent of sodium hyaluronate with the molecular weight of 400,000 to 800,000 and 1 to 2 percent of polysulfonic acid mucopolysaccharide. The result of the embodiment shows that the patch with weak mechanical property is adaptive to the part with weak cuticle and sensitive skin, and the patch with strong mechanical property is adaptive to the part with thick cuticle. Through the physical permeation promotion effect of microcrystals, polysulfonic acid mucopolysaccharide can be efficiently carried to penetrate through a skin barrier to directly reach a target part, and the medicine utilization rate is remarkably increased; the formula is simple in components, the skin irritation risk is reduced from the source, and the production cost is reduced.

The invention provides a composition with an effect of relieving keratosis pilaris and a preparation method of the composition, and relates to the technical field of cosmetics. The allantoin in the raw materials can directly act on keratin of skin, increase and promote the hydration capacity of cuticle, soften skin cuticle protein and remove keratinocytes, and acts together with the hydroxyethyl piperazine ethanesulfonic acid to promote falling of aged cuticle and promote cell proliferation and tissue growth, so that the skin care effect is improved. The updating speed of keratinocytes and a small part of upper epidermis cells is accelerated, so that the aged skin is regenerated, and the keratosis pilaris is improved. The composition provided by the invention is mild in components and good in effect.

The invention discloses a micro-capsule wrapped high-stability active face cream preparation method based on digital simulation driving, and relates to the technical field of face cream preparation, the micro-capsule wrapped high-stability active face cream preparation method comprises the following steps: constructing a multi-physical field coupling simulation model, and importing skin microenvironment parameters, micro-capsule structure parameters and active component parameters; shell degradation, active molecule diffusion and stratum corneum permeation full-chain dynamic behaviors of the microcapsules on the skin surface are simulated through the model, and a release rate-absorption rate matching curve is output; reversely adjusting the capsule material components and the shell crosslinking degree of the microcapsules according to the curve; constructing a capsule material molecular dynamics simulation model, analyzing capsule material molecular chain degradation paths and key sites in different environments, and designing a capsule material molecular structure; and constructing a digital twinborn body, simulating and predicting raw material fluctuation influence, and adjusting preparation parameters. According to the method, the micro-capsule parameters, the capsule material molecular structure and the preparation parameters are regulated and controlled by combining multi-dimensional parameters through the synergistic effect of a multi-physical field coupling simulation system, a capsule material molecular dynamics simulation system and a digital twin three-stage simulation system.

The invention belongs to the technical field of medical evaluation, and relates to a method for evaluating damage of air pollution to human skin health based on a PPO-LSTM fusion algorithm. The method comprises the following steps: acquiring multi-source data; preprocessing data, and constructing a multi-dimensional time sequence feature data set; establishing a PPO-LSTM fusion model, performing feature extraction and reinforcement learning optimization on the multi-dimensional time sequence features, and outputting skin health core indexes; performing prediction and quantitative evaluation on the functional states of the cuticle, the epidermal layer and the corium layer; generating a personalized nursing decision scheme for skin health maintenance; outputting corresponding early warning information and coping suggestions by judging the risk levels of the skin barrier function and the dermal metabolism function; and updating parameters of the skin health injury evaluation model. According to the method, multi-dimensional data are integrated in the same model at the same time, the evaluation dimension is more comprehensive, the accuracy of skin health injury evaluation is improved, and a complete closed loop from detection evaluation to nursing scheme generation and risk prompt is realized through decision making and early warning.

The invention relates to the technical field of cosmetics, and particularly discloses a degradable microneedle temperature control type striae gravidarum repairing film patch and a preparation method thereof. Comprising four layers of structures which are sequentially compounded from outside to inside: a nanofiber substrate layer; a microneedle essence layer; a temperature control adjusting layer; and attaching a fixing layer. By constructing a four-layer collaborative system, the day and night temperature rhythm of the skin is converted into a trigger signal, and a temperature response-microneedle degradation-drug release linkage closed loop is achieved. The degradable microneedle can be utilized to break through a cutin barrier, repair components are accurately delivered to a corium layer, anti-inflammatory and collagen-promoting components can be released at night in an accelerated manner through a temperature control mechanism, and the mode is automatically switched to a slow-release stability maintaining mode in the daytime, so that accurate matching with a human physiological repair rhythm is achieved.

The present application relates to the field of cosmetic technology, and more particularly to a full-link whitening and freckle-removing liposome and a preparation method thereof, the liposome comprising the following components: an aqueous phase, a membrane material and an oil phase. In the preparation process, 4-butyl resorcinol, nonapeptide-1, acetylchitosamine and ascorbic acid tetraisopalmitate are combined to form a full-link effect of signal inhibition-synthesis blockage-blocked conversion-metabolic acceleration, and a multi-target whitening and freckle-removing system is constructed. In addition, tranexamic acid, hydrolyzed yeast protein and schizophyllan are combined to synergistically make the finished product have excellent soothing and moisturizing effects. Furthermore, the finished product is prepared into a liposome capable of encapsulating active ingredients, which effectively improves the stability of the active ingredients, prevents their oxidation and inactivation, and the liposome structure is highly similar to the human cell membrane, is easy to penetrate the keratin layer gap, realizes targeted delivery to the deep layer of the epidermis, and makes the active ingredients truly act on the required site.

The present invention discloses a glucosamine derivative nanoparticle and preparation method and use thereof. By self-assembling glucosamine derivatives and ethanol into the form of nanoparticles, the skin penetration rate and cell absorption rate of glucosamine are improved, and at the same time the toxicity to cells and organisms is reduced. The problem of poor absorption of glucosamine is improved by using glucosamine derivative nanoparticles. Furthermore, the glucosamine derivative nanoparticles can be used as a delivery carrier to cover and bring the specified ingredients into the cells or stratum corneum, and to increase the skin penetration rate and cell absorption rate of the specified ingredients.

The application provides a long-acting external use efinaconazole composition, a preparation method and application, and belongs to the technical field of pharmaceutical compositions.The long-acting external use efinaconazole composition comprises the following components in percentage by weight: efinaconazole 0.5-3%, a film forming agent 3-7%, a gel agent 2-3%, a plasticizer 3-7%, a cosolvent 0.78-1.56% and a solvent in a residual amount.The application forms a eutectic mixture of efinaconazole and lactic acid, improves the solubility and permeability of the active ingredient, dissolves in the solvent of an ethanol system, and adds the film forming agent and the plasticizer, so that a drug depot is formed on the surface of the skin through the film forming principle, the drug is released slowly, the clinical compliance is improved, the frequency of drug administration is reduced, the bioavailability of the drug in the stratum corneum is increased, the effectiveness and safety of the drug can be improved, the basic theory of pharmacoeconomics is met, and the clinical value of the product is improved.

The invention provides a composition with skin tightening and brightening effects and application thereof. The composition with the skin tightening and brightening effects is prepared from collagen, acetyl hexapeptide-8, olive fruit oil, meadowfoam seed oil and rose flower oil. The invention creatively finds that the five components of collagen, acetyl hexapeptide-8, olive fruit oil, meadowfoam seed oil and rose flower oil are matched with one another and have synergistic interaction, so that the moisture content of cuticle can be remarkably increased, the glossiness and elasticity of skin are improved, and excellent skin tightening and brightening effects are achieved.

The preparation method of the biomimetic stratum corneum and the biomimetic skin with tissue-like differentiation structure belongs to the technical field of transdermal drug delivery. Polymer microspheres are dispersed in a lipid mixture to obtain lipid-coated microspheres, and then a polymer-lipid composite film with a brick-mortar-like structure is formed by hot pressing, thereby obtaining a biomimetic stratum corneum highly consistent with the structure of human stratum corneum. The biomimetic stratum corneum not only has anisotropic ultrastructure in the natural stratum corneum, but also shows a permeation barrier function highly consistent with the ex vivo human skin. The biomimetic stratum corneum is co-cultured with an artificial tissue culture skin to prepare a biomimetic skin, so as to introduce skin metabolic function and / or serve as a hair follicle stem cell carrier, and construct a biomimetic skin containing a hair follicle structure. The present application is suitable for in vitro transdermal penetration test and evaluation of drugs and cosmetics, and provides reliable and efficient alternative materials and methods to solve the problems of poor predictability and large individual differences of existing animal skin models.

The present invention relates to a non-therapeutic cosmetic composition for increasing the cellular mitochondrial respiration of keratinocytes underlying the stratum corneum of the epidermis, comprising an active complex: extracts of Melaleuca alternifolia, extracts of Lavandula hybrida, and melatonin. The invention also relates to the use of this non-therapeutic cosmetic composition for increasing the cellular mitochondrial respiration of keratinocytes underlying the stratum corneum of the epidermis.

The invention discloses a cleaning care solution, the care solution comprises a functional component and an auxiliary component besides water, the mass ratio of the functional component to the auxiliary component is (1.0-3.0): (10-20), and the functional component comprises a polyamino acid polysaccharide condensate aqueous solution and folic acid. The cleaning care solution has the following functions: (1) the cleaning care solution is used for cleaning female vulva parts; (2) moisturizing the stratum corneum of the human body; (3) promoting proliferation of lactobacillus at the vulva part; and (4) inhibiting the growth of pathogenic bacteria and maintaining the micro-ecological balance of the vulva.

The application provides a water-triggered self-assembly gel, a use method and application thereof. The water-triggered self-assembly gel comprises 5-aminolevulinic acid hydrochloride 5-15 wt%, phospholipid 5-10 wt%, anionic glycolipid surfactant 0.2-0.8 wt%, polyethylene glycol 50-60 wt%, propylene glycol 20-27 wt% and antioxidant 0.05-0.1 wt%, and water <0.1 wt%; the mass ratio of the polyethylene glycol and the propylene glycol is (2-2.5):1. The water content of the water-triggered self-assembly gel is extremely low, so that the stability is good and the storage is easy; when used, the water-triggered mechanism of transdermal water loss can be used to actively extract water from the stratum corneum, the phase transition of the phospholipid from the disordered lamellar phase to the liposome is quickly completed, the nanometer liposome with uniform particle size and high encapsulation efficiency is spontaneously formed, the 5-ALA hydrochloride is wrapped, and the 5-ALA hydrochloride can be efficiently delivered to the deep layer of the skin.

The application provides an adenosine co-crystal and a preparation method and application thereof, and belongs to the technical field of biological medicines.The adenosine co-crystal is formed by adenosine and ikar or nicotinamide according to a molar ratio of 1:0.2-16.9, and overcomes the problem of poor bioavailability of adenosine in the prior art.The adenosine co-crystal provided by the application has a significantly higher solubility compared with adenosine, can improve the blood drug concentration in vivo as a medicine to further play a more effective therapeutic role, can avoid the influence of the hydrophobicity of the stratum corneum to further improve the skin permeability of the product as a skin care product or a cosmetic product, and can improve the solubility of the effective component in the product to better play a hair growth effect as a hair growth product, and has wide application potential.The preparation method of the co-crystal has simple steps, high efficiency, low cost, and the advantages of being suitable for large-scale production.

This invention discloses a pharmaceutical composition, a topical formulation, a method for producing the same, and its use. The pharmaceutical composition of this invention comprises the drug-active ingredient, diethylene glycol monoethyl ether, and polyethylene glycol 400, wherein the pharmaceutical composition does not contain water, and the mass ratio of diethylene glycol monoethyl ether to polyethylene glycol 400 is 1:(0.5~4.0), and the drug-active ingredient has structural formula (I). Topical formulations produced from the pharmaceutical composition provided by this invention have stable properties and do not crystallize, have a good feel, promote rapid penetration of the drug into the stratum corneum, have excellent epidermal and dermal retention ability, deliver the drug to the target on the skin, reduce systemic side effects, can achieve high local concentrations, have excellent therapeutic effects and stability, and can reduce safety risks. JPEG2026518290000036.jpg65142

The present disclosure provides a method for intradermal delivery of a serum comprising pre-conditioning a target area of the subject's stratum corneum by contacting the area with a device comprising a cartridge and nanotip, the pre-conditioning comprising moving the device in vertical, horizontal, and circular motions over the target area for 15 to 20 seconds per 2×2 cm portion to mechanically abrade the stratum corneum; filling the cartridge with a serum composition comprising biologically active agents; inserting the cartridge into the device inlet and holding vertically for 5 seconds; applying the serum to the pre-conditioned area by actuating the device to vibrate at 5800 to 8800 revolutions per minute and dispense serum through micro-ports positioned adjacent the nanotip, comprising moving the device in vertical, horizontal, and circular motions for up to 60 seconds; and optionally massaging the serum into the treated area.

This invention belongs to the field of cosmetic technology and discloses a skin care and hair care liquid composition of water-based polyurethane-10 and type III collagen. This invention combines water-based polyurethane-10 and type III collagen in a specific ratio, utilizing the residual NCO groups (or urea groups, carbamate groups) in polyurethane-10 to form a strong hydrogen bond cross-linking network with the amino and carboxyl groups in collagen molecules. This allows the collagen to firmly adhere to the skin or hair surface, while simultaneously softening the stratum corneum, resulting in a smooth skin feel and achieving multiple effects such as long-lasting moisturizing, improved elasticity, and wrinkle concealing.

The invention discloses a postoperative blackening inhibiting and brightening repairing body lotion and a preparation method thereof, the postoperative blackening inhibiting and brightening repairing body lotion comprises the following components by mass: 1-3% of tranexamic acid, 2-5% of nicotinamide, 3-6% of an aloe vera extract, 0.5-2% of menthol, 0.1-0.5% of an anti-allergy agent, 5-10% of a humectant, 2-4% of an emulsifier, 0.5-1% of a thickener, 0.05-0.2% of a pH regulator, 0.3-0.8% of a preservative, and the balance of deionized water. The invention has the following beneficial effects: by adding tranexamic acid into the formula, the activity of tyrosinase and melanocyte proliferation can be inhibited, melanin generation can be reduced from the source, nicotinamide can block melanin from being transferred to cuticle, and nicotinamide and tranexamic acid generate a synergistic effect, so that the blackness inhibition effect can be enhanced; the anti-inflammatory and moisturizing functions can be provided, then the postoperative skin inflammation reaction is reduced, menthol added in the formula can generate cooling feeling when activated, postoperative pain and scorching discomfort are effectively relieved, and the anti-allergy agent can reduce the skin allergy risk and improve the product safety.

This invention discloses a lip mask composition and its preparation method. The lip mask composition comprises a film-forming agent, a thickener, an emulsifier, oil, and water. The film-forming agent comprises polyvinyl alcohol with a viscosity of less than 35 mPa·s, sodium polystyrene sulfonate, and *Pteris vittatum* polysaccharide. The thickener comprises sodium alginate and lithium distearate dimethylammonium montmorillonite. During preparation, an oil phase and an aqueous phase are prepared separately. Sodium alginate is added to the aqueous phase, and then the oil phase is added to the aqueous phase. After homogenization, lithium distearate dimethylammonium montmorillonite is added, followed by homogenization and defoaming. This lip mask composition has a novel user experience, a noticeable immediate visual effect (the appearance of the lip mask can be observed to change), and a long-lasting effect. After the film is formed, it can be peeled off completely, which can reduce the evaporation of skin moisture and help the moisturizers in the formula to gently penetrate into the stratum corneum without irritating the skin barrier. After peeling off the film, old keratin on the lips is removed, leaving the lips feeling refreshed, breathable, and non-sticky. It immediately improves dry lips and brightens lip color after use.