30results about How to "Minimal irritation" patented technology

The invention relates to methods and devices for remote or distributed continuous monitoring of physiologically relevant states. The invention provides for methods to automatically detect deviations or other states in physiological parameters and automatically alert a measured subject, user or other authorized party. The device provides for a universal platform for sensors, and further provides for the automatic compensation or distribution of devices or bioactive agents at appropriate levels and / or intervals in response to deviations or other states sensed in various physiological parameters.

A device includes a plurality of microneedles for abrading the stratum corneum of the skin to form a plurality of grooves in the tissue having a controlled depth and width. The microneedles have a length of about 5-250 microns and generally about 5-200 microns. The device is rubbed over the skin to prepare an abraded site after which a transdermal delivery or sampling device is applied to the abraded delivery site. The abrasion increases the permeability of the skin and the rate of delivery and extraction of a substance without pain or irritation to the patient.

The lack of safe, reliable, automated and clinically acceptable blood sampling has been the main problem precluding the development of real-time systems for blood analysis and subsequent closed-loop physiological function control. While the analysis of a static blood sample in laboratory conditions has been rapidly advancing in reliability and blood volume reduction, non-invasive real-time blood analysis performed in vivo (while the blood is circulating in the body) has been elusive and unreliable. In this study we propose an innovative idea for semi-invasive blood sampling and analysis, which resembles the operation of a mosquito. At a miniature scale the proposed system does penetrate the skin to extract a static blood sample for further analysis, but the extent of this penetration, and the fact that it can be made painless, is particularly attractive for such applications as automated glucose analysis for closed-loop control of insulin infusion (artificial pancreas), continuous drug monitoring, or even periodic DNA analysis for security and identification purposes. These design aspects are described, and a specific implementation, applying MEMS (Micro Electro Mechanical Systems) technology, is suggested. The proposed microsystem is a matrix of individually controllable e-Mosquito™ cells, packaged in a disposable patch and attached to the skin, could be an avenue for real-time semi-invasive blood analysis and diagnostics.

A shaver that includes a cartridge with one or more razor blades and a source of RF energy operative to apply RF energy to one or more of the blades. The cartridge can be attached to a handle for moving the cartridge along the surface of the skin. The cartridge may include a variety of configurations including one or more electrodes and one or more blades with the RF current conducting through any subset of the electrodes and blades, through the skin, thereby heating the skin to help facilitate the engagement of the blade with the hair on the skin surface.

The present invention discloses a device and method to establish and maintain bone stabilization and enhance post-operative healing in a surgical site, such as the cervical spine of a patient, with reduced risk of erosion or other injury to adjacent anatomic structures from extrusion of surgical fasteners, such as bone screws. The surgical stabilization system according to the present invention provides for the secure plating of structures such as adjacent vertebral bodies with allowance for selective postoperative motion of the surgical fasteners used to secure the plate. Such motion imparts benefit from increased translational response and remodeling in the course of bone healing, thus resulting in strengthened fusion.

A composition includes at least one antimicrobial agent; a possible solvent system with either hydrophobic or hydrophilic nature, selected according to the target of usage; as well as possible surface active agent. The compound mixture is obtained by pulverizing wood or plant material and / or by extracting the possibly pulverized wood or plant material, so that the compound mixture contains at least two different polyphenolic compounds selected from the following group: lignans, stilbenes, juvabiones and flavonoids; the compound mixture further containing oligomers of the polyphenolic compounds, so that the compound mixture preferably has the following properties: the compound mixture has an antimicrobial effect in the composition; the cytotoxicity of the polyphenols contained in the compound mixture is at least 10 times lower with respect to BHT; the compound mixture does not irritate the skin in a so-called single patch test with contents of 0.1 wt %.

A device includes a plurality of microneedles for abrading the stratum corneum of the skin to form a plurality of grooves in the tissue having a controlled depth and width. The microneedles have a length of about 5-250 microns and generally about 5-200 microns. The device is rubbed over the skin to prepare an abraded site after which a transdermal delivery or sampling device is applied to the abraded delivery site. The abrasion increases the permeability of the skin and the rate of delivery and extraction of a substance without pain or irritation to the patient.

A shaver that includes a cartridge with one or more razor blades and a source of RF energy operative to apply RF energy to one or more of the blades. The cartridge can be attached to a handle for moving the cartridge along the surface of the skin. The cartridge may include a variety of configurations including one or more electrodes and one or more blades with the RF current conducting through any subset of the electrodes and blades, through the skin, thereby heating the skin to help facilitate the engagement of the blade with the hair on the skin surface.

The present invention provides a short pant comprising: a body having a plurality of fabric sections assembled together in a seamless manner having a front region, a back region, and opposing side regions forming a pelvic region, a pair of thigh regions, an inner surface, and an outer surface; and a closure system, operatively coupled to the body at the pelvic region at a top waist edge, for securing the short pant during wearing; and the pair of thigh regions each having a bottom edge and having a slit on each opposing side region substantially perpendicular to and extending from the bottom edge upward a distance toward the top waist edge. The present invention may be used for athletics, such as for combat sports training or competition. The short pant comprising a seamless body and side slits for minimal irritation, for providing a lightweight short pant, for minimal hook-and-loop in the closure while maintaining proper fit and allowing unrestricted movement.

The invention is directed to a shear system for an electric hair removing apparatus, in particular for an electric shaving apparatus, including at least one shearing unit having an outer cutter and an undercutter that are set in relative motion. The shear system of the invention includes at least one feeding device arranged to precede the shearing unit and is characterized in that the feeding device is set in motion relative to the outer cutter.

A urinary catheter with an improved retaining and activating feature is provided which is a safe device with reduced irritation and discomfort to a patient. The retaining mechanism positioned at the proximal end of the catheter assumes a “close” state for introduction and removal of the catheter into and from the urethral tract, and is transitioned into the “open” state when the catheter is in the bladder by mechanically manipulating the retaining mechanism through the activation mechanism. An actuating linkage wire connected between the retaining mechanism and activation mechanism controllably reciprocates in the channel of the catheter to transition the catheter between the “open” and “closed” states.

The present invention discloses a device and method to establish and maintain bone stabilization and enhance post-operative healing in a surgical site, such as the cervical spine of a patient, with reduced risk of erosion or other injury to adjacent anatomic structures from extrusion of surgical fasteners, such as bone screws. The surgical stabilization system according to the present invention provides for the secure plating of structures such as adjacent vertebral bodies with allowance for selective postoperative motion of the surgical fasteners used to secure the plate. Such motion imparts benefit from increased translational response and remodeling in the course of bone healing, thus resulting in strengthened fusion.

A urinary catheter with an improved retaining and activating feature is provided which is a safe device with reduced irritation and discomfort to a patient. The retaining mechanism positioned at the proximal end of the catheter assumes a “close” state for introduction and removal of the catheter into and from the urethral tract, and is transitioned into the “open” state when the catheter is in the bladder by mechanically manipulating the retaining mechanism through the activation mechanism. An actuating linkage wire connected between the retaining mechanism and activation mechanism controllably reciprocates in the channel of the catheter to transition the catheter between the “open” and “closed” states.

A heat stimulating personal lubricant. A package and method for generating the heat stimulating personal lubricant is also disclosed.

An antimicrobial composition and methods of use are provided. The antimicrobial composition includes a water-soluble antimicrobial organosilane ammonium compound and a sugar. The composition may be in liquid, foam, ointment or gel form. The composition may include anti-inflammatory medications, alcohol and / or steroids. The antimicrobial composition may be used to treat eye infections in humans and animals. The antimicrobial composition may be applied directly to the surface of the eye. The antimicrobial composition may further be used to treat ocular related articles, including contact lenses, contact cases, instruments, pads and the like. The antimicrobial composition may be applied directly to the surface of the ocular related article during and / or after manufacture.

This invention relates to long-acting injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a poloxamer, and a co-solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the long-acting injectable formulations of the invention to the animal in need thereof.

The present invention relates to methods of alleviating pain with the administration of norketamine with a narcotic. More particularly, the invention provides a method of alleviating pain through the administration of a dose of norketamine, which, if administered alone would provide sub-optimal analgesic relief, yet provides analgesic relief when combined with a narcotic. In some embodiments, the combination of norketamine with a narcotic, further allows for the administration of a dose narcotic, which would be sub-optimal if used alone, but provides adequate pain relief in combination with norketamine. The invention relates to self-management of pain on an outpatient basis comprising administering via conventional routes, including transdermal, nasal, rectal, oral, transmucosal, intravenous, intramuscular, and other routes, one or more doses of norketamine / opioid compositions effective to alleviate pain to a subject suffering from pain. Uses of norketamine / opioid compositions would also apply, to treating headaches, drug abuse, mood and anxiety disorders, as well as other, neuropsychiatric disorders, both motoric and cognitive, such as Alzheimer's disease, Parkinson's syndrome, which are thought to be caused by neurodegeneration.

A topical ophthalmological composition includes a muscarinic receptor antagonist as an active pharmaceutical ingredient; and a semifluorinated alkane, as a liquid vehicle. The topical ophthalmological composition treats an ocular disease.

A non-irritation, non-blurring ophthalmic sunscreen composition contains a liquid vehicle base, such as an artificial tear formulation or an ophthalmic suspension or ointment. The composition includes at least one inorganic and / or at least one organic active ingredient. The inorganic active ingredients may include, but not be limited to zinc oxide, titanium dioxide, iron oxide, zirconium oxide, and cerium oxide. The organic active ingredients may include, but not be limited to dioxybenzone, octinoxate, octisalate, homosalate, avobenzone, octocrylene, para-aminobenzoic acid, cinoxate, methyl anthranilate, octocrylene, padimate O, ensulizole, sulisobenzone, trolamine salicylate, and ecamsule.

The hair curling kit of the present invention preferably comprises a first parting device, a second parting device, and respective first, second, and third types of conventional hair rollers to facilitate the curling of hair for a myriad of hairstyles. The parting devices are designed to uniformly and quickly part a section of hair that corresponds to a respective type of hair roller included in the hair curling kit. The parting of hair is accomplished with a single passage of the parting device along the roots of the hair and scalp without requiring a second parting that is customary with conventional combs. The segregated hair is engaged to conventional hair rollers included with the hair curling kit in order to curl hair for a myriad of hairstyles. The parting devices can alternatively include integral elements that facilitate the combing and / or picking of hair with a single implement.

A composition having antimicrobial activity is provided. The composition includes a compound mixture obtained from pulverized and / or extracted wood material that contains polyphenols (i) lignans, (ii) stilbenes and (iii) oligomers of lignans, stilbenes juvabiones or flavonoids. The cytotoxicity of the polyphenols in the compound mixture is at least ten times lower compared to butylated hydroxytoluene (BHT) and does not irritate the skin in a so-called single patch test at 0.1 wt %. The composition further includes an antimicrobial agent such as betulin, betulonic acid, betulinic acid, betuloinic acid, resveratrol or ethylhexyl glyceryl. The composition can be used in cosmetic and hair care products.

A non-irritation, non-blurring, photostable ophthalmic sunscreen composition contains at least one of the following: bemotrizinol; bisoctrizole; tris-biphenyl triazine; and / or octyl methoxycinnamate. A liquid vehicle base is then a remainder of the solution by weight. The composition is an artificial tear formulation or an ophthalmic suspension or ointment. The composition may include at least one inorganic and / or at least one organic active ingredient. The inorganic active ingredients may include, but not be limited to zinc oxide, titanium dioxide, iron oxide, zirconium oxide, and cerium oxide. The organic active ingredients may include, but not be limited to dioxybenzone, octinoxate, octisalate, homosalate, avobenzone, octocrylene, para-aminobenzoic acid, cinoxate, methyl anthranilate, octocrylene, padimate O, ensulizole, sulisobenzone, trolamine salicylate, and ecamsule.

This invention relates to long-acting injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a poloxamer, and a co-solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the long-acting injectable formulations of the invention to the animal in need thereof.

This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and / or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.

The present invention provides a method of identifying an orthodontic adhesive on a tooth structure, the method including selectively staining a surface including the orthodontic adhesive or the tooth structure. Methods of bonding and debonding an orthodontic appliance to and from a tooth structure are also provided.

A non-irritation, non-blurring ophthalmic sunscreen composition contains a liquid vehicle base, such as an artificial tear formulation or an ophthalmic suspension or ointment. The composition includes at least one inorganic and / or at least one organic active ingredient. The inorganic active ingredients may include, but not be limited to zinc oxide, titanium dioxide, iron oxide, zirconium oxide, and cerium oxide. The organic active ingredients may include, but not be limited to dioxybenzone, octinoxate, octisalate, homosalate, avobenzone, octocrylene, para-aminobenzoic acid, cinoxate, methyl anthranilate, octocrylene, padimate O, ensulizole, sulisobenzone, trolamine salicylate, and ecamsule.