611 results about "Aminobenzoic acid" patented technology

The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular, nicotine salts with mucic acid, 3,5-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid, and crystalline polymorphic forms of nicotine 4-acetamidobenzoate, nicotine gentisate, and nicotine 1-hydroxy-2-naphthoate are described. The invention further provides methods of preparation and characterization of such nicotine salts, co-crystals, and salt co-crystals and polymorphic forms thereof. In addition, tobacco products, including smoking articles, smokeless tobacco products, and electronic smoking articles comprising nicotine salts, co-crystals, and / or salt co-crystals are also provided.

Oral care compositions having improved taste, said compositions comprising: a carrier material; from about 0.001 to about 10%, by weight of the composition, of an oral care component selected from metal salts, antimicrobial agents, bad breath reduction agents, bleaching agents, surfactants, or a combination thereof; and from about 0.0001 to about 1%, by weight of the composition, of a TRPA1 agonist selected from vanillin esters; benzoate esters; hydroxybenzoate derivatives; methoxy benzoate derivatives; hydroxybutanedioate derivatives; benzamidobenzoate derivatives; methylpropanoate derivatives; phenyl acetate derivatives; hex-3-enoate derivatives; 2-(furan-2-ylmethylsulfanyl)-3-methylpyrazine; phenylmethoxymethylbenzene; (2R)-2-azaniumyl-3-[(2R)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3E)-2-hydroxy-4,8-dimethylnona-3,7-dienal; (2R)-2-azaniumyl-3-[(2S)-2-azaniumyl-3-oxido-3-oxopropyl]disulfanylpropanoate; (3Z)-3-butylidene-2-benzofuran-1-one; 3-methyl-N-(3-methylbutyl)butan-1-imine; 2-(furan-2-ylmethyldisulfanylmethyl)furan; and combinations thereof. Uses thereof and methods of improving the taste of an oral care composition.

Novel expression vectors and constructs encoding a chloroplast transit peptide (CTP) operably linked to a monomeric anthranilate synthase are provided. Additionally, novel polynucleotide sequences encoding monomeric anthranilate synthases are provided. Also provided are methods for increasing the levels of free tryptophan in transgenic plants containing the expression vectors and constructs.

Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and / or depressing cortical and / or peripheral neuron activity are disclosed. Novel derivatives of N-phenylanthranilic acid are also disclosed.

Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

The invention discloses a method for detecting the quality of a compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins, mainly comprising the steps of detecting whether the inclusion of the capsule is yellow or tangerine powder or particles, differentiating, checking the loss on drying and measuring the contents of amino acids, vitamin C, niacinamide, vitamin B1, vitamin B6, vitamin B2, calcium pantothenate, folic acid, vitamin A, vitamin D2, vitamin E and 5-hydroxy o-aminobenzoic acid in the capsule by adopting the high-performance liquid chromatography. The method for detecting the quality of the compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins is scientific and reasonable, has high degree of accuracy, good repeatability, can comprehensively and effectively control the quality of the compound capsule prepared from 8 kinds of amino acids and 11 kinds of vitamins, and can ensure the clinical efficacy of the preparation.

The present invention is directed to a method of inducing neurogenesis by administering to a mammal an effective quantity of a compound that induces neurogenesis, where neurogenesis includes proliferation of neural stem and progenitor cells, differentiation of these cells into neurons, and / or survival of these new neurons. In general, the compound comprises three moieties, A, L, and B, covalently linked. A can be a purine, tetrahydroindolone, or pyrimidine; L is a linker, while B is a moiety that promotes absorption of the compound. A particularly preferred compound is N4-[[3-(6-oxo-1,6-dihydropurin-9-yl)-1-oxopropyl] amino] benzoic acid (also known as AIT-082 or leteprinim potassium). Another aspect of the invention is pharmaceutical compositions for inducing neurogenesis.

The invention provides a preparation method and application of an anti-soil polymer. The prepared polymer is used as a dispersant for a hydraulic cementing agent and / or an aqueous dispersion for potential hydraulic cementing agent and has good anti-soil performance. The preparation method the anti-soil polymer comprises a step of subjecting polyether macromonomer A with a special structure, monomer B containing a phosphoric acid or phosphorous acid group, optional monomer D and aldehyde C to condensation polymerization so as to prepare the anti-soil polymer, wherein the monomer D is selected from the group consisting of phenol, aniline, p- / o-aminobezene solfonic acid, p- / o-hydroxybenzoic acid, p- / o-aminobenzoic acid, p- / o-hydroxyezene solfonic acid, p- / o-toluidine and p- / o-methylphenol, a mol ratio of the polyether macromonomer A to the monomer B to the monomer D is 1: (0.5-12): (0-8.0), and a mol ratio of the polyether macromonomer A to the monomer B and the monomer D is 1: (0.5-12.0).

The invention relates to a method for preparing 4-(3-chlorine-4-fluorophenylalanine)-7-methoxy-6-[3-(4-morpholinyl) propoxy] quinazoline (I). The method takes 4-methoxy-2-nitrobenzoic acid as initial material which is subjected to reduction and nitration to obtain 4-methoxy-5-nitryl-2-aminobenzoic acid, is then subjected to cyclization to obtain 7-methoxy-6-nitryl quinazoline-4(3H)-ketone, is again subjected to reduction and diazo reaction hydrolysis to obtain 7-methoxy-6-hydroxy quinazoline-4(3H)-ketone, after etherification reaction is carried out, phosphorus oxychloride is used for preparing 7-methoxy-6-[3-(4-morphjolinyl) propoxy]-4-chloroquinazoline, which is subjected to amination to obtain the compound in the formula (I). The initial material adopted by the preparation method is convenient and accessible, the cost is low, the process route is simple and reasonable, the three wastes produced in the process of preparation generates less pollution, therefore the preparation method can prepare final product with high quality and yield in mass production, and is suitable for industrialized production.

The invention discloses high-wear-resistant antibacterial acrylate paint. The high-wear-resistant antibacterial acrylate paint is prepared from the raw materials: an aqueous acrylate emulsion, alkyd resin, organosilicon modified unsaturated polyester resin, silica sol, cellulose acetate butyrate, polyvinyl pyrrolidone, modified nano-titania, calcium carbonate whiskers, octadecyl trimethyl ammonium chloride modified montmorillonite, hollow glass beads, zinc oxide, ethylene glycol mono-n-propyl ether, di-propanediol butyl ether, triethylene glycol monoethyl ether, an anti-settling agent, a humectant, an antifoamer, per-methoxylation melamine resin, 3,5-dimethyl-2-aminobenzoic acid, trimethylaniline, a leveling agent, vinyl triethoxysilane and deionized water. The high-wear-resistant antibacterial acrylate paint provided by the invention is high in hardness, good in wear resistance, excellent in antibacterial performance and long in service life.

The invention relates to a thermoplastic polyimide (TPI) material used for preparing a two-layer flexible copper clad laminate (2L-FCCL). The excellent dissolvability TPI material is obtained through generating a polyamide acid copolymer by using main reaction components 4-ethoxydiphenol-3,5-diaminobenzoate and 2,2-bis(4-aminophenyl)hexafluoropropane according to a specific molar ratio, a corresponding diamine and a corresponding acid anhydride, and processing the copolymer by utilizing a chemical imidization process. The 2L-FCCL with good comprehensive performances of dimensional stability, dip soldering resistance, peeling performance and the like can be obtained through dissolving powder of the TPI material and compositing the TPI material with a thermosetting polyimide film and copper foil.

The present invention relates to stabilised <99m>Tc radiopharmaceutical compositions, which include both a radioprotectant and one or more antimicrobial preservative(s), and hence have an extended lifetime of use. The radioprotectant is ascorbic acid, para-aminobenzoic acid, gentisic acid or a salt thereof with a biocompatible cation, and the antimicrobial preservative is one or more compound from the paraben series of preservatives. The invention is particularly useful for cationic, lipophilic <99m>Tc heart imaging agents such as Myoview(TM).

The invention relates to preparation and application of a zinc ion fluorescence probe based on Schiff base. A zinc ion fluorescence probe compound has the structure shown by a formula I. The preparation method comprises the steps that 2-aminobenzoic acid (methyl anthranilate) and hydrazine hydrate are subjected to heating reflux in ethyl alcohol to obtain a white solid II, cyanophenyl phenol, anhydrous magnesium chloride and paraformaldehyde are subjected to heating reflux in a triethylamine-containing acetonitrile solution to obtain a white solid III, the white solid II and the white solid III are subjected to heating reflux in ethyl alcohol to a yellow solid I. The probe compound has very good selectivity and sensitivity on zinc ions, is low in detection limit and can be applied to determination of the content of zinc ions in a water body.

A method for producing 2-amino-5-iodobenzoic acid which comprises bringing 2-aminobenzoic acid (A) and molecular iodine (B) into reaction with each other in the liquid phase in the presence of an oxidizing agent. Hydrogen peroxide is preferable as the oxidizing agent. This method does not require a step for purifying 2-amino-5-iodobenzoic acid or a step for recovering iodine, and 2-amino-5-iodobenzoic acid having excellent quality can be produced economically advantageously with a great yield. The product can be advantageously used as an intermediate for drugs, an agricultural chemical and a raw material for functional chemicals.

The invention belongs to a marine chemical engineering technology, and concretely relates to a marine organism polysaccharide Schiff base derivative, a preparation method thereof, and an application thereof as an agricultural bactericide. The polysaccharide Schiff base derivative is an O-carboxymethyl chitosan aminobenzoic acid Schiff base derivative, and is represented by general formula I; and in the formula I, X is a carboxyl and methyl co-substituted phenyl group, a carboxyl and halogen co-substituted phenyl group or a carboxylphenyl group, and n is 1000-8000. The O-carboxymethyl chitosan aminobenzoic acid Schiff base derivative has good dissolvability and can be dissolved in various solvents, so the application field of the derivative is enlarged, the derivative has bacteriostatic activity and metal ion adsorption function, can kill agricultural pathogenic bacteria, and also can remove copper ions and other heavy metal ions enriched in cultivated land. The derivative has potential application values in the field of pesticides.

The present disclosure concerns methods and compositions to inhibit insects from biting a subject. In preferred embodiments, the compositions may be administered orally, for example using a spray bottle to deliver to the mouth. In certain embodiments, the compositions and methods are effective to reduce swelling, itching, redness and / or inflammation of the local area of an insect bite. The compositions may include one or more herbs selected from the group consisting of rice bran, peppermint, barley grass, lobelia; chlorella, watercress, alfalfa and parsley and one or more vitamins selected from the group consisting of thiamin (B-1), riboflavin (B-2), niacin (B-3), pantothenic acid (B-5), pyridoxine (B-6), folic acid (B-9), cyanocobalamin (B-12), choline, inositol, d-biotin, para-aminobenzoic acid, and lecithin. Administration of effective amounts of the compositions is sufficient to inhibit insects from biting and / or treat insect affected areas of a subject.

The present invention provides transgenic plants transformed with an isolated DNA encoding a monomeric anthranilate synthase. The present invention also provides an isolated DNA encoding a monomeric anthranilate synthase from Agrobacterium tumefaciens. Transformation vectors and transformed plants containing the isolated DNA and seeds derived therefrom, are also provided.

The invention provides a novel synthetic method of a bis-benzoxazine ketone ultraviolet absorbent, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: A, stirring, anhydrides, used as raw materials, of o-aminobenzoic acid and (o-, m-, p-) phthaloyl dichloride or (o-, m-, p-)phthalic acid for a certain time in a non-polar solvent; B, adding chemical dehydrating agent or physical dehydrating agent in a reaction system without separating, slowly heating and refluxing for a certain time to obtain (o-, m-, p-)substituted bis-benzoxazine ketone ultraviolet absorbent; wherein the stirring time in the step A is not less than 1 hour, the refluxing time is 5-10 hours in the step B, the chemical dehydrating agent used in the step B is various dehydrating agents reacted with the water, including but not limited to alkaline calcium oxide, soda lime, acidic concentrated sulfuric acid, concentrated phosphoric acid, polyphosphoric acid, phosphorus pentoxide, thionyl chloride, acetic anhydride and the like, neutral molecular sieve, water-absorbent, anhydrous cupric sulfate and the like; the physical dehydrating agent comprises but not limited to non-protonic solvent such as benzene, methylbenzene, xylene and the like. The method provided by the invention has the advantages of being simple in operation flow, low in cost, simple in equipment, and suitable for the scale industrial production.

The invention discloses a novel technology for synthesizing an intermediate of trityl candesartan; the synthesis steps thereof comprise: (1) a preparation method of 2-menthyl formate-6-nitryl-benzoic acid; (2) a preparation method of 2-amido-3-nitryl-methyl benzoate; (3) a preparation method of 2, 3-diaminobenzene menthyl formate; (4) a preparation method of 2-oxethyl-4-menthyl formate-3-H-benzimidazole; and (5) the preparation method of the intermediate of trityl candesartan.

The invention relates to reaction-type halogen-free flame retardant bis-(p-aminocarboxyphenyl)phenylphosphine oxide and its synthetic method and application and belongs to the field of preparation of a flame retardant. The synthetic method comprises the following steps: using glacial acetic acid as a solvent, adding para amino benzoic acid into glacial acetic acid, slowly dropwise adding dichlorophenylphosphine oxide into an acetic acid solution of para aminobenzoic acid, continuously stirring and reacting at 85-95 DEG C for 4-6 h, and absorbing hydrogen chloride discharged by the reaction by the use of aqueous alkali; and cooling a reaction product after the end of the reaction, carrying out suction filtration, washing and drying to obtain white powdery bis-(p-aminocarboxyphenyl)phenylphosphine oxide. The bis-(p-aminocarboxyphenyl)phenylphosphine oxide flame retardant has advantages of low toxicity, low smoke, innocuousness, high efficiency and the like, is a reactive flame retardant integrating a carbon source, an acid source and a gas source, and is applied in inherent flame retarding of nylon or thermoplastic polyester copolymer.

The invention provides a method for measuring the vanadium content of silicon ferrovanadium, which includes the steps: (a) mixing silicon ferrovanadium and nitric acid, adding hydrofluoric acid into mixture, heating the mixture to completely dissolve the silicon ferrovanadium, adding sulfuric acid into the mixture, heating the mixture until the moment of smoking, and afterwards cooling the mixture; (b) adding phosphoric acid into the mixture, heating the mixture until smoking, keeping smoking for a period of time and cooling the mixture; (c) adding sulfuric acid into the mixture, cooling the mixture, adding potassium permanganate solution into the mixture until appearing of stable red and allowing the mixture to stand for a period of time; (d) adding urea solution into the mixture, dripping sodium nitrite solution into the mixture to reduce excessive potassium permanganate, excessively adding 1-3 drops of sodium nitrite solution and then allowing the mixture to stand for a period of time; (e) adding N-phenyl o-aminobenzoic acid indicators into the mixture and then dripping ammonium ferrous sulfate standard solution into the mixture to obtain a titration endpoint when the mixture is light green; and (f) computing the vanadium content according to the formula.

The invention provides use of 2-(substituted phenylamino) benzoic acid and ester compound thereof in preparation of an FTO (Fat Mass and Obesity-Associated Protein) inhibitor. The invention particularly discloses the use of 2-(substituted phenylamino)-benzoic acid and the ester compound and a pharmaceutically acceptable salt thereof which are shown in the formula I in preparation of the FTO inhibitor or a pharmaceutical composition for treating FTO-related diseases.

The invention discloses an aromatic diamine containing imidazolyl and a preparation method thereof. Tetramines aromatic and aminobenzoic acid are taken as raw materials, and an imidazole ring is formed by reaction between carboxyl and o-amino in a polyphosphoric acid medium, thus preparing 2,2'-bi(4-amino phenyl)-5,5'-bisbenzimidazole, 2,2'-bi(3-amino phenyl)-5,5'-bisbenzimidazole, 2,2'-bi(4-amino phenyl)bisbenzimidazole, 2,2'-bi(3-amino phenyl)bisbenzimidazole, 2,2'-bi(4-amino phenyl)imidazopyridine or 2,2'-bi(3-amino phenyl)imidazopyridine which belong to a novel aromatic diamine containing imidazolyl that is an important monomer raw material for preparing various polyamides and polyimides, so as to enrich the variety of the aromatic diamine containing imidazolyl and polymers, and have broad application prospect in the fields of high-performance fibers, fuel cells and the like.

The invention generally relates to biological engineering of microorganisms and production of chemical compounds therefrom. More particularly, the invention relates to novel genetically engineered microorganisms for the fermentative production of p-aminobenzoic acid and related compounds from fermentable carbon substrates. The biologically derived PABA and related compounds from fermentable carbon substrates can be used in a number of applications including as a food supplement or raw materials for the syntheses of other industrial chemicals or polymers.

The invention discloses chitosan ester p-aminobenzoate, which has a structure shown in the specifications, wherein X is between 0.65 and 0.95, and the molecular weight is between 70 and 80 kilodaltons. The materialization indexes of the compound are that: the chitosan ester p-aminobenzoate is a pale yellow powder solid, can be dissolved in water and is dissolved in ethanol and isopropanol slightly. After a p-animo-benzoyl structure is introduced into a chitosan molecular chain, the minimum inhibitory concentration of the compound on staphylococcus aureus and aspergillus niger is 0.1 percent and 0.25 percent respectively, so the chitosan ester p-aminobenzoate can be used as food antiseptic additives.

The invention relates to the field of synthesis of high polymer materials, particularly a preparation method of poly-p-aminobenzoylamonoundecylamine, which comprises the following steps: (1) salification: uniformly stirring 20 parts by weight of aminoundecanoic acid, 14 parts by weight of p-aminobenzoic acid, 150 parts by weight of distilled water and 0.2 part by weight of catalyst, reacting at 120 DEG C for 3 hours, carrying out vacuum filtration, washing, and carrying out vacuum drying to obtain PA11T salt; (2) feeding: stirring uniformly the PA11T salt, distilled water or organic solvent with the same weight as the PA11T salt, and a blocking agent accounting for 0.6-1.2% (w / w) of the PA11T salt to obtain a mixture; and (3) reaction synthesis: heating the mixture to 270-290 DEG C in a protective gas atmosphere, pressurizing to 2.5-3 MPa, keeping the temperature and pressure for 2 hours, reducing to atmospheric pressure within 2 hours while heating to 310-330 DEG C, keeping the temperature for 2 hours, vacuumizing to -0.095 MPa, keeping the temperature and pressure for 1 hour, and discharging, thereby obtaining the PA11T.