6results about How to "Effective activity" patented technology

The application discloses a method for treating antibiotic wastewater by using a graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate, and the method is characterized by using the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst to activate persulfate for degrading and treating antibiotic wastewater, wherein the graphdiyne / ferrous indium sulfide nanocomposite comprises ferrous indium sulfide nanoparticles, and the nanoparticles are loaded with graphdiyne nanosheets. The method for treating antibiotic wastewater by using the graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate uses the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst, wherein the nanocomposite has many reactive sites, high catalytic activity and good stability, can efficiently activate persulfate with a smaller amount of catalyst, can efficiently remove antibiotics in wastewater, and has the advantages of low cost, high treatment efficiency, good removal effect, green environmental protection and the like, and therefore, the method has important significance for effectively purifying antibiotic wastewater, has high use value and good application prospect.

The application belongs to the technical field of cell culture, and discloses a T cell activation and expansion method based on self-adaptive liquid-liquid interface and application thereof. The application provides application of a liquid-liquid interface culture system in T cell activation and expansion, wherein the liquid-liquid interface comprises a two-dimensional liquid-liquid interface and a liquid-liquid interface microsphere, both of which can form a protein nanofilm at an oil-water interface, and the protein nanofilm is used to load molecules providing T cell receptor activation signals and / or molecules providing T cell costimulatory signals, so as to construct a self-adaptive T cell activation interface with dynamic molecular display capability. Compared with a traditional rigid solid culture dish and a magnetic bead system, the liquid-liquid interface has fluidity, molecular migration and interface responsiveness, and is more conducive to T cell receptor aggregation, formation of an immunological synapse-like structure and synergistic integration of T cell receptor activation signals and costimulatory signals.

The application relates to the technical field of biomedical materials, and specifically discloses a preparation method of a double-crosslinked 3D-printed bone repair scaffold. The scaffold is made of a biphasic calcium phosphate matrix and a gelatin methacrylate hydrogel outer layer. The preparation method comprises the following steps: firstly, preparing biphasic calcium phosphate ink, and constructing a porous scaffold blank through 3D printing; then, carrying out double-crosslinking treatment of calcium chloride solution and glutaraldehyde solution in sequence to obtain a scaffold matrix with enhanced mechanical properties; then, preparing gelatin methacrylate hydrogel loaded with modified teriparatide, and compounding the gelatin methacrylate hydrogel with the scaffold matrix; and finally, obtaining the final product after blue light crosslinking and solidification. The bone repair scaffold has good biocompatibility and osteogenic activity, and can effectively promote bone defect repair. In addition, the preparation method is controllable and has good repeatability, the structure of the scaffold is accurately controlled through the 3D printing technology, and a new approach is provided for the preparation of personalized bone repair materials.

The invention discloses a dynamic culture amplification method of NK cells or engineered derivatives thereof, and belongs to the technical field of biology. The method comprises the following steps: sorting peripheral blood to obtain NK cells; mixing the culture medium with K562 feeder cells according to a first proportion, and carrying out first co-culture activation and amplification; optionally, carrying out CAR (chimeric antigen receptor) gene transduction; mixing the amplified NK cells or the transduced cells with K562 feeder cells according to a second proportion, and carrying out secondary co-culture activation and continuous amplification under a dynamic culture condition; and finally, the NK cells or the CAR-NK cells are obtained. The method breaks through the limitation of traditional standing co-culture, realizes efficient and stable amplification of NK / CAR-NK cells under dynamic conditions, has the advantages of high amplification efficiency, high cell viability and purity, simplified operation and easy large-scale amplification, and provides a new technical scheme for preparation of immune cell therapy products.

This utility model discloses an ecological water filtration pond for aquatic ecological restoration, relating to the field of ecological restoration. The ecological water filtration pond comprises, from top to bottom, a coarse filtration layer, a fine filtration layer, a biofilm layer, an aeration layer, and a disinfection layer. The aeration layer contains an aeration device, and the disinfection layer contains an ultraviolet sterilization device. This utility model, by integrating multiple key functional layers, including a physical filtration layer, a biological treatment layer, an aeration and disinfection system, and a real-time water quality monitoring system, not only significantly improves water purification efficiency but also enhances system stability and adaptability, reducing long-term operation and maintenance costs. Furthermore, by introducing aquatic plants and biofilm technology, it further promotes the restoration of aquatic ecosystems and enhances biodiversity, providing a novel solution for aquatic ecological restoration that is both highly efficient, economical, and eco-friendly.

The application belongs to the field of fluorinated chemicals, and particularly relates to an amino-functionalized mesoporous organosilica composite material, a preparation method and application in preparation of hydrofluoroether. The preparation method comprises the following steps: (1) preparing gold nanoparticles; (2) preparing mesoporous silica-based materials loaded with gold nanoparticles and forming hollow structures and functional modification. The amino-functionalized mesoporous organosilica composite material as a catalyst exhibits excellent catalytic activity. Gold nanoparticles as active centers can effectively activate the double bond in hexafluoropropylene molecules with reduced electron cloud density due to strong electron-withdrawing groups, significantly improving the conversion rate of the reaction and solving the problem of low raw material utilization rate caused by low activity of traditional catalysts.