15results about How to "Effective activity" patented technology

The invention discloses a carbon dioxide hydrogenation methanation-cracking carbon preparation series method, which comprises the following steps: generating CH4 through a reaction of # imgabs0 # imgabs1 #, and realizing the production of a carbon material by adopting the technologies of condensation separation of CH4 and water vapor, CH4 cracking reaction of # imgabs2 #, cyclic utilization of hydrogen and the like. The process is composed of a carbon dioxide hydrogenation methanation reactor and a methane cracking reactor. In the methanation reactor, CO2 and H2 react under a low-temperature condition to generate CH4 and water vapor; cH4 and water vapor are separated by adopting a compressor condensation separation technology, and the separated CH4 is conveyed to a cracking reactor. In the methane cracking reactor, CH4 is cracked at a high temperature to generate H2 and a carbon nanomaterial, and then H2 is returned to the methanation reactor again. The separation of CH4 and water vapor at a relatively low temperature is realized in the tandem carbonization process through a low-temperature condensation technology; through low-temperature CO2 methanation and CH4 catalytic cracking, the content of CO2 is reduced, a high-quality carbon nanomaterial is obtained, and cyclic utilization of CO2 and H2 is realized.

The invention discloses a liver function biochemical composite quality control product as well as a preparation method and application thereof. The quality control product comprises 12 analyte raw materials and the following non-analyte raw materials: 5 to 12 g / L of sodium chloride, 0.5 to 2 g / L of casein sodium salt, 5 to 20 g / L of mannitol, 0.05 to 0.2 g / L of Tween 20, 1 to 20 mg / L of bright aprotinin, 10 to 60 g / L of trehalose and 0.05 to 0.2 g / L of PC300. And matrix liquid: 20-80% of quality control substance matrix liquid and 20-80% of buffer solution. The liver function biochemical composite quality control product disclosed by the invention has high compositing property, contains 11 important liver function biochemical indexes, is excellent in component uniformity and stability, ensures the precision of each index, and meets the requirements of daily quality control.

The invention discloses a preparation method and application of a carbon-based single-atom oxygen reduction reaction electrocatalyst, using dopamine functionalized polypyrrole nanoparticles as a skeleton material, ethylenediaminetetraacetic acid and bipyridine as ligands, and forming a multi-level stable loaded complex with Fe-O and Fe-N coordination structure on the skeleton material through dynamic timing ligand regulation, gradual temperature increase and coordination time control, and then the obtained complex-loaded polypyrrole nanoparticles are subjected to 200-300°C low-temperature pre-calcination, corrosive gas etching and 500-900°C high-temperature step-by-step calcination treatment to stably generate FeN4 / Fe2O3 active site structure linked by N-Fe-O bridge bonds, and at the same time obtain a rich pore structure to optimize the contact between electrolyte and active site, and finally prepare a carbon-based single-atom oxygen reduction reaction electrocatalyst. The oxygen reduction reaction electrocatalyst prepared by the present invention exhibits excellent catalytic activity and catalytic stability.

The application discloses a method for treating antibiotic wastewater by using a graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate, and the method is characterized by using the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst to activate persulfate for degrading and treating antibiotic wastewater, wherein the graphdiyne / ferrous indium sulfide nanocomposite comprises ferrous indium sulfide nanoparticles, and the nanoparticles are loaded with graphdiyne nanosheets. The method for treating antibiotic wastewater by using the graphdiyne / ferrous indium sulfide nanocomposite to activate persulfate uses the graphdiyne / ferrous indium sulfide nanocomposite as a catalyst, wherein the nanocomposite has many reactive sites, high catalytic activity and good stability, can efficiently activate persulfate with a smaller amount of catalyst, can efficiently remove antibiotics in wastewater, and has the advantages of low cost, high treatment efficiency, good removal effect, green environmental protection and the like, and therefore, the method has important significance for effectively purifying antibiotic wastewater, has high use value and good application prospect.

The present invention relates to a heterocyclic compound as a Janus kinase (JAK) inhibitor or a pharmaceutically acceptable salt thereof. Specifically, the present invention relates to a compound as represented by general formula (I) or a pharmaceutically acceptable salt thereof. The present invention also relates to a process for preparing the compound or a pharmaceutically acceptable salt thereof. The compounds of the present invention can be used for treating and / or preventing JAK-mediated related diseases, in particular inflammatory diseases, autoimmune diseases, and cancers. The definition of each substituent in the general formula (I) is the same as that in the description.

The application belongs to the technical field of cell culture, and discloses a T cell activation and expansion method based on self-adaptive liquid-liquid interface and application thereof. The application provides application of a liquid-liquid interface culture system in T cell activation and expansion, wherein the liquid-liquid interface comprises a two-dimensional liquid-liquid interface and a liquid-liquid interface microsphere, both of which can form a protein nanofilm at an oil-water interface, and the protein nanofilm is used to load molecules providing T cell receptor activation signals and / or molecules providing T cell costimulatory signals, so as to construct a self-adaptive T cell activation interface with dynamic molecular display capability. Compared with a traditional rigid solid culture dish and a magnetic bead system, the liquid-liquid interface has fluidity, molecular migration and interface responsiveness, and is more conducive to T cell receptor aggregation, formation of an immunological synapse-like structure and synergistic integration of T cell receptor activation signals and costimulatory signals.

The application relates to the technical field of biomedical materials, and specifically discloses a preparation method of a double-crosslinked 3D-printed bone repair scaffold. The scaffold is made of a biphasic calcium phosphate matrix and a gelatin methacrylate hydrogel outer layer. The preparation method comprises the following steps: firstly, preparing biphasic calcium phosphate ink, and constructing a porous scaffold blank through 3D printing; then, carrying out double-crosslinking treatment of calcium chloride solution and glutaraldehyde solution in sequence to obtain a scaffold matrix with enhanced mechanical properties; then, preparing gelatin methacrylate hydrogel loaded with modified teriparatide, and compounding the gelatin methacrylate hydrogel with the scaffold matrix; and finally, obtaining the final product after blue light crosslinking and solidification. The bone repair scaffold has good biocompatibility and osteogenic activity, and can effectively promote bone defect repair. In addition, the preparation method is controllable and has good repeatability, the structure of the scaffold is accurately controlled through the 3D printing technology, and a new approach is provided for the preparation of personalized bone repair materials.

The present invention relates to the field of catalyst technology, and in particular to a preparation method, product and application of a biochar-based catalyst. The preparation method of the biochar-based catalyst comprises the following steps: step 1, dissolving two precursor substances containing Mn and metal N respectively in water to obtain a homogeneous solution; step 2, adding the homogeneous solution to an alkaline solution containing waste residue L and keeping the pH of the reaction system alkaline, aging, and obtaining a mixed solution; step 3, filtering and washing the mixed solution, and then drying to obtain a hydrotalcite-like composite material containing N, Mn and L; step 4, calcining the hydrotalcite-like composite material containing N, Mn and L to obtain the biochar-based catalyst. The present invention not only realizes the recycling of waste, but also the prepared catalyst can efficiently catalytically reduce nitrogen oxides in flue gas at low temperature, and also has good low-temperature anti-poisoning performance and regeneration performance, which conforms to the concept of "treating waste with waste".

The invention discloses a dynamic culture amplification method of NK cells or engineered derivatives thereof, and belongs to the technical field of biology. The method comprises the following steps: sorting peripheral blood to obtain NK cells; mixing the culture medium with K562 feeder cells according to a first proportion, and carrying out first co-culture activation and amplification; optionally, carrying out CAR (chimeric antigen receptor) gene transduction; mixing the amplified NK cells or the transduced cells with K562 feeder cells according to a second proportion, and carrying out secondary co-culture activation and continuous amplification under a dynamic culture condition; and finally, the NK cells or the CAR-NK cells are obtained. The method breaks through the limitation of traditional standing co-culture, realizes efficient and stable amplification of NK / CAR-NK cells under dynamic conditions, has the advantages of high amplification efficiency, high cell viability and purity, simplified operation and easy large-scale amplification, and provides a new technical scheme for preparation of immune cell therapy products.

The present disclosure relates to an anti-CD73 antibody and application thereof in treating diseases caused by coronavirus infection. Specifically, a heavy chain variable region of the antibody contains amino acid sequences such as HCDR1 - HCDR3 as shown in SEQ ID NOs: 15-17; and the light chain variable region of the antibody contains amino acid sequences such as LCDR1 - LCDR3 as shown in SEQ ID NOs: 18 - 20.

The present application provides a control method and device for a data packet replication function, and a communication device; the control method for the data packet replication function includes: the communication device determines to deactivate or activate the data packet replication function; the communication device performs an operation of deactivating or activating the data packet replication function accordingly. The present application can effectively activate or deactivate the data packet replication function.

The present invention relates to an alkynylphenylbenzamide compound and the use thereof. The alkynylphenylbenzamide compound of the present invention has a structure as shown in formula (I), can be used as a protein kinase inhibitor, can effectively inhibit the activity of a TRK protein kinase and can inhibit the proliferation, migration and invasion of various tumor cells, and also has the characteristics of good pharmacokinetics and low toxicity.

This utility model discloses an ecological water filtration pond for aquatic ecological restoration, relating to the field of ecological restoration. The ecological water filtration pond comprises, from top to bottom, a coarse filtration layer, a fine filtration layer, a biofilm layer, an aeration layer, and a disinfection layer. The aeration layer contains an aeration device, and the disinfection layer contains an ultraviolet sterilization device. This utility model, by integrating multiple key functional layers, including a physical filtration layer, a biological treatment layer, an aeration and disinfection system, and a real-time water quality monitoring system, not only significantly improves water purification efficiency but also enhances system stability and adaptability, reducing long-term operation and maintenance costs. Furthermore, by introducing aquatic plants and biofilm technology, it further promotes the restoration of aquatic ecosystems and enhances biodiversity, providing a novel solution for aquatic ecological restoration that is both highly efficient, economical, and eco-friendly.

The application belongs to the field of fluorinated chemicals, and particularly relates to an amino-functionalized mesoporous organosilica composite material, a preparation method and application in preparation of hydrofluoroether. The preparation method comprises the following steps: (1) preparing gold nanoparticles; (2) preparing mesoporous silica-based materials loaded with gold nanoparticles and forming hollow structures and functional modification. The amino-functionalized mesoporous organosilica composite material as a catalyst exhibits excellent catalytic activity. Gold nanoparticles as active centers can effectively activate the double bond in hexafluoropropylene molecules with reduced electron cloud density due to strong electron-withdrawing groups, significantly improving the conversion rate of the reaction and solving the problem of low raw material utilization rate caused by low activity of traditional catalysts.

The utility model discloses a heat preservation henhouse convenient to collect excrement, and relates to the technical field of livestock breeding, the heat preservation henhouse comprises a henhouse main body and a cleaning assembly, the lower end of the side edge of the henhouse main body is provided with a recovery opening, a bearing net plate is erected at the position, close to the ground, in the henhouse main body, and a collecting pool is arranged under the bearing net plate; the cleaning assembly is arranged on the side edge of the collecting pool. According to the heat preservation henhouse facilitating excrement collection, the collection pool of a sunken structure is arranged on the inner ground of the henhouse body, meanwhile, through cooperation with operation of the cleaning assembly, excrement in the collection pool can be regularly cleaned through the cleaning assembly, so that an operator can collect the cleaned excrement at the position of a recycling opening for follow-up treatment, and the working efficiency is improved. By means of the supporting pile and fixing pile assembly, the bearing net plate can be erected above the collecting pool, so that chickens can be blocked from excreted excrement while moving, contamination of the excrement is prevented, and recycling and cleaning of the excrement are facilitated.