3170 results about "Gelatin" patented technology

It is disclosed new conducting and stretchable hydrogels and “one-pot” process to making them from natural and eco-friendly components, including gelatin, chitosan, and glycerol. Various conducting materials, such as poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS), thermally reduced graphene (TRG), or MXene are introduced in the hydrogels to enhance their conductivity. The resulting conducting hydrogels exhibit remarkable robustness, do not require crosslinking agent, and possess a unique thermo-reversible property, simplifying the fabrication process and ensuring enhanced long-term stability. Moreover, their fabrication is sustainable, employing environmental-friendly materials and processes, while retaining their skin-friendly characteristics. It is also disclosed hydrogel electrodes that were tested for ECG signal acquisition and outperformed the commercial electrodes. The hydrogel-based electrodes deliver high-quality ECG signals, boasting a superior signal-to-noise ratio (SNR) and remarkable resilience against interference and motion artifacts, compared to their commercial AgCl counterparts.

The invention discloses bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement. The bone cement for orthopedic repair comprises solid-phase powder and a liquid-phase component, the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate, 10-15 parts of bioactive glass, 2-3 parts of a developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of a modified toughening agent and 2-3 parts of nano cellulose fibers; the liquid phase component is prepared from the following components in parts by weight: 40 to 50 parts of a sodium alginate solution, 10 to 20 parts of methacrylated gelatin, 0.5 to 1 part of transglutaminase, 30 to 60 parts of a citric acid buffer solution and 1 to 2 parts of an antibacterial agent. The preparation method comprises the following steps: reacting pentaerythritol with 12-oxododecanoic acid to obtain an intermediate 1, and reacting the intermediate 1 with dopamine to prepare the modified toughening agent. The bone cement for orthopedic repair prepared by the invention has good mechanical, self-repairing and antibacterial properties.

The present invention belongs to the technical field of biomedical materials. Disclosed are a methacrylate, a succinate-diesterified starch, a preparation method therefor and the use thereof in an in-situ filler for corneal defects. The methacrylate, succinate-diesterified starch is prepared by means of performing graft carboxylation on starch and then grafting a double bond. The in-situ filler for corneal defects consists of the methacrylate succinate-diesterified starch (StacMA), gelatin methacryloyl (GelMA), a photoinitiator and a solvent. The corneal filler has a good biocompatibility, an excellent photoresponsive adhesion property and excellent mechanical properties, and can be used for promoting the regeneration of the natural structure of a damaged cornea and the reconstruction of visual function.

The invention discloses photocuring hydrogel capable of being combined with cytokines and used for tumor organoid culture and application, and belongs to the technical field of organoid culture. According to the invention, the hydrogel which can fix cells, can be combined with cell factors and can realize organoid recovery is developed through norbornene modified heparin, norbornene modified gelatin, sulfydryl four-arm polyethylene glycol, glucan, matrix metal protein peptidomimetic MMP and a photoinitiator. The hydrogel can be used for directly preparing organoids, heparin of various structures can be used, the cost is reduced, the modified heparin can bind factors or matrix protein and can controllably release the factors, the modified gelatin provides amino acid energy for collagen hydrolysate, and the hydrogel is formed by photocuring in a stepwise polymerization mode, is controllable in structure and can be used for preparing collagen collagen. The adjustable bionic modulus and the adjustable bionic stress relaxation are realized. The hydrogel disclosed by the invention can be used for culturing various organs, overcomes the problems of low repeatability, instability and the like in the prior art, and is suitable for the fields of tumor drug evaluation and the like.

The invention discloses an intelligent quality inspection system for medicinal empty capsules, particularly relates to the field of intelligent detection, and comprises a multi-dimensional optical characteristic acquisition module, a dynamic thermodynamic response analysis module, a near infrared spectrum component inversion module, a multi-source data fusion decision module and a self-adaptive feedback optimization module. Omnibearing nondestructive detection of the capsule is realized through non-contact multispectral imaging and vibration response analysis, traditional destructive sampling loss is thoroughly avoided, and the multisource data fusion module integrates optical texture features, mechanical frequency domain energy density and near infrared spectrum inversion values based on the D-S evidence theory, so that the detection accuracy is improved. And the self-adaptive optimization module dynamically adjusts an optical wavelength weight, a mechanical sweep frequency range and a spectrum modeling parameter by applying reinforcement learning, is self-adaptive to fluctuation of different batches of gelatin materials and environmental interference, remarkably reduces a misjudgment rate and ensures continuous and stable operation of a production line.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a film coating agent for accelerating stabilization of a weathering resistant steel rust layer in a severe atmospheric environment. The film coating agent comprises a film-forming agent and a spraying agent, the film-forming agent comprises a gel agent and a transforming agent; the gel is prepared from one or more of tannic acid, carbomer, chitosan and gelatin; the transforming agent comprises one or more of magnesium sulfate, zinc sulfate and sodium molybdate; the spraying agent comprises an accelerant and an aggressive agent; the accelerant comprises one or more of sodium sulfate, potassium sulfate and chromium sulfate; the aggressive agent comprises one or more of sodium chloride, aluminum chloride and sodium fluoride. The film coating agent provided by the invention can form a stable and uniform rust layer on the surface of the weathering resistant steel, so that the corrosion resistance of the weathering resistant steel is improved.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention belongs to the technical field of biology, and discloses a stable protective agent, a cell antigen dry sheet and a preparation method and application of the dry sheet, the stable protective agent comprises glycerin with the volume fraction being 0.4%, gelatin with the mass volume fraction being 0.1%, EDTA with the mass volume fraction being 0.1 mM, trehalose with the mass volume fraction being 0.03% and resveratrol with the mass volume fraction being 100 [mu] M. The stable protective agent is adopted for preparing the cell antigen dry sheet, and the cell antigen dry sheet is applied to CBA detection. The stable protective agent has good permeability, can penetrate through cell membranes to enter cells, provides a protection effect inside and outside the cells, has moisture retention and oxidation resistance, can prevent cell deformation and cell fixing layer shedding, and can well maintain the stability and reliability of antigen proteins, and the prepared cell antigen dry sheet can be stored for a long time, and has a good application prospect. The antigenicity of a membrane signal index is not damaged. When a positive sample is detected, obvious green fluorescence cells can be seen, red fluorescence quenching is avoided, and co-localization of red fluorescence and green fluorescence can be observed conveniently.

The invention relates to a starch-based soft capsule shell and a preparation method thereof. The starch-based soft capsule shell is prepared from the following raw materials in parts by mass: 60 to 70 parts of hydroxypropyl starch, 9 to 20 parts of carrageenan, 5 to 15 parts of diquat, 5 to 15 parts of polylysine, 5 to 10 parts of hydroxypropyl methyl cellulose acetate succinate, 15 to 20 parts of glycerol and 30 to 40 parts of pure water. According to the soft capsule shell, hydroxypropyl starch serves as a base material, gelatin is not added, the conditions of poor weather resistance and fishy smell caused by use of gelatin are avoided, through the synergistic effect of all the components, the defects that a starch-based material is poor in plasticity, fragile and insufficient in mechanical strength are overcome, the structural stability is enhanced through chemical crosslinking, and the mechanical strength is improved; and the mechanical property is improved by virtue of physical compounding, so that the low-temperature resistance, high-temperature resistance and mechanical strength of the capsule skin are improved.

The present invention discloses automated soft capsule production equipment and a speed regulation method, relating to the field of food and pharmaceutical equipment manufacturing, and is designed to achieve automated soft capsule production. The automated soft capsule production equipment includes an electronic control system, a liquid infusion system, a gelatin strip conveyor system, and a soft capsule pressing and molding system. The electronic control system is connected to the liquid infusion system, the gelatin strip conveyor system, and the soft capsule pressing and molding system, respectively. The gelatin strip conveyor system includes a thickness sensor for measuring the thickness of the conveyed gelatin strip and transmitting a measurement signal to the electronic control system. The gelatin strip conveyor system also includes an angle sensor assembly for measuring the tightness of the conveyed gelatin strip and transmitting a measurement signal to the electronic control system. The electronic control system receives and processes the measurement signal and transmits a control signal to a motor in the gelatin strip conveyor system to adjust the thickness or tightness of the gelatin strip. The liquid infusion system automatically closes and opens the infusion switch via the electronic control system, and the soft capsule pressing and molding system automatically controls the mold compression or release via the electronic control system.

The invention discloses an intelligent gradient extraction process and method for nutritional ingredients in yak bone marrow, and belongs to the technical field of bioactive substance extraction. The extraction method comprises the following four steps: gradient pressure supercritical degreasing, double-enzyme synergistic gradient enzymolysis, acid concentration gradient demineralization and temperature gradient gelatin extraction, and through the process coupling design of gradient pressure degreasing, buffer enzymolysis, graded acidolysis and membrane separation of gelatin, the high yield of the product in the previous stage is ensured; active structures of follow-up components are reserved to the greatest extent. Meanwhile, a sensing-decision-execution closed-loop system is constructed, real-time data sources such as NIR moisture sensing, online OPA detection and XRD in-situ analysis are integrated, technological parameters are dynamically adjusted through a multi-objective optimization algorithm, and global optimization of the yield, the purity and the energy consumption is achieved.

The invention relates to the technical field of environmental restoration, in particular to a slow-release material for synergistically restoring heavy metal and organic compound contaminated soil based on modified biochar and microorganisms and an application method thereof.The slow-release material is prepared from, by weight, 50-80 parts of modified biochar, 30-40 parts of sodium alginate, 10-20 parts of gelatin, 5-10 parts of glycerin and 3-5 parts of calcium carbonate. The multi-modified biochar is prepared from, by weight, 300-400 parts of a functional flora mixed solution and 5-10 parts of mixed nutrient elements of glucose, yeast extract and KHPO, and through the synergistic effect of the multi-modified biochar and the functional flora, efficient immobilization (the immobilization rate gt is 60%) of heavy metal (lead, cadmium and chromium) and efficient degradation (the degradation rate gt is 70%) of organic pollutants (polycyclic aromatic hydrocarbon and petroleum hydrocarbon) are achieved.

The invention relates to the technical field of production process intelligent regulation and control, in particular to an intelligent regulation and control method and system for an instant gelatin production process, and the method specifically comprises the following steps: firstly, collecting process parameters such as reaction kettle temperature, acid-base concentration and the like in a production line sensor and control system to form production batch data; then, an optimization model and an intelligent regulation and control strategy are constructed, a dynamic incidence matrix is constructed through time-varying mutual information entropy, multiple types of features are fused to generate a process state descriptor, a constraint dominating relation and a population initialization strategy are optimized, and a self-adaptive genetic manipulation adjustment mechanism and a state-guided search and constraint processing method are designed; iteratively executing an improved NSGA-II algorithm, obtaining an optimized Pareto solution set, and evaluating diversity; and finally, selecting an optimal solution through a multi-criterion decision and a dynamic regulation and control strategy, and converting the optimal solution into an executable process parameter set value. According to the method, the accuracy and the high efficiency of the production process can be improved by realizing intelligent optimization regulation and control of the process parameters.

The invention provides a combined fermented product of ginseng, astragalus membranaceus and donkey-hide gelatin as well as a preparation method and application of the combined fermented product, and relates to the technical field of pharmaceutical preparations. The combined leavening is obtained by fermenting ginseng, astragalus membranaceus and donkey-hide gelatin, and the mass ratio of the ginseng to the astragalus membranaceus to the donkey-hide gelatin is (1-3): (10-30): 1. The composition of ginseng, astragalus membranaceus and colla corii asini is subjected to probiotic fermentation, macromolecular saponin is converted into aglycone or secondary saponin with smaller molecules, protein is split into peptide chains with smaller molecules, polysaccharide is split into sugar chains with smaller molecules, absorption and utilization of effective components of the medicine are facilitated, and the effect of tonifying qi and blood can be rapidly achieved.

The invention provides a preparation method of a cell culture three-dimensional scaffold and cell culture meat, which comprises the following steps: firstly, preparing a gelatin-carrageenan mixed solution and a gel precursor solution of transglutaminase, dividing into two parts, incubating at constant temperature to obtain two parts of composite hydrogel, randomly freeze-drying one part to obtain aerogel, and freeze-drying the aerogel to obtain the cell culture three-dimensional scaffold. Stacking on the other part and incubating at constant temperature again to obtain the prefabricated double-layer gel. The prefabricated double-layer gel is directionally frozen, ice crystals grow upwards from the bottom, freezing is stopped after the temperature is reduced to the set temperature, and the cell culture three-dimensional scaffold is obtained through drying. The stent adopts an ordered-disordered partition design, parallel micro-channels are formed in the lower layer by using a directional ice template method, and muscle fiber arrangement is simulated; a porous spongy structure is constructed on the upper layer by using a random ice template method, and is adapted to adipocyte proliferation. Two layers of interfaces are interpenetrated and communicated, natural mechanical gradients are combined, natural tissue characteristics are re-engraved, the traditional limitation is broken through, the cell co-culture efficiency and the cultured meat quality are improved, and industrialization is promoted.

The invention discloses a traditional Chinese medicine composition with the effects of benefiting qi, nourishing blood, invigorating the spleen and tonifying the kidney and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: cistanche, ginseng, American ginseng, astragalus membranaceus, medlar, rhizoma polygonati, oyster peptide, angelica sinensis, radix rehmanniae preparata, donkey-hide gelatin, fructus amomi, pericarpium citri reticulatae, hawthorn, folium cortex eucommiae, radix puerariae, liquorice and the like. The preparation method comprises the following steps: respectively crushing the medicinal materials, dissolving the colla corii asini, mixing, adding water, granulating and the like. The composition can be prepared into various dosage forms such as granules, capsules, tablets, oral liquid and the like. Experiments show that the traditional Chinese medicine composition can effectively improve the symptoms of deficiency of qi and blood (increasing erythrocyte count and hemoglobin content), weakness of spleen and stomach (increasing body weight and improving pepsin activity) and kidney deficiency (reducing creatinine and urea nitrogen content and improving SOD activity), and acute toxicity experiments show that the toxicity is slightly reversible under high dosage, and the safety is good under therapeutic dosage. The traditional Chinese medicine composition has potential application value in the aspect of preparing medicines for benefiting qi, nourishing blood, invigorating spleen and tonifying kidney.

The invention belongs to the field of high polymer material chemistry, and particularly relates to double-network hydrogel based on sodium alginate / gelatin, a preparation method and dressing. A chemical method of grafting modification is adopted, grafting modification is carried out by designing abundant active groups on side chains of gelatin and sodium alginate, and based on traditional gelatin or sodium alginate hydrogel, not only is the thermal stability of gelatin improved, but also the biological activity of sodium alginate is improved, and the antibacterial property is achieved; the finally prepared SD / GelMA dual-network hydrogel wound dressing not only has excellent mechanical properties, but also has very high biocompatibility and antibacterial activity, and has huge application prospects and potential in the aspect of skin wound healing.

The present invention provides a gel candy containing DHA and a preparation method thereof. The gel candy containing DHA of the present invention is made of the following raw materials: 1-10 parts of edible colloid, including one or more of pectin, gelatin, carrageenan, agar, starch, locust bean gum, and xanthan gum; 75-90 parts of sweetener; 5-15 parts of DHA microcapsule powder; 2-10 parts of moisture retainer; 0.5-5 parts of acidity regulator-buffer salt pair, including one or more of citric acid and its sodium salt or potassium salt, DL-malic acid and its sodium salt, lactic acid and its sodium salt. The present invention also provides a preparation method for the above-mentioned gel candy, adding DHA microcapsule powder and acidity regulator-buffer salt pair in the last stage before casting and molding and mixing evenly; it can be cast into a solid or sandwich product, and the moisture content of the obtained gel candy is 8-20%. The gel candy of the present invention has no fishy smell during the shelf life of 18 months, and the product does not return to sand or melt.

The invention discloses a method for preparing a methylacryloyl chitosan / gelatin-based hydrogel wound dressing through 3D printing and application, and relates to a method for preparing a hydrogel wound dressing and application. The problems that existing MXene is high in photo-thermal conversion temperature, and bacteria rapidly breed again after near-infrared irradiation is closed are solved. The ZGC composite hydrogel wound dressing integrates multiple functions, can simultaneously realize hemostasis, antibiosis, anti-inflammation, vascularization promotion and cell regeneration, and is especially suitable for infectious wounds. The antibacterial performance can be achieved under the activation of near-infrared light through the dual effects of a photothermal therapy and a photodynamic therapy, and meanwhile, the antibacterial effect can be achieved in cooperation with Zn < 2 + >. The ZGC composite hydrogel wound dressing can be accurately customized and printed through a 3D printing technology according to the shape and depth of a wound, the composite dressing can achieve accurate low-temperature photo-thermal treatment, meanwhile, the continuous release of Zn < 2 + > and the physical antibacterial function of MXene are maintained, normal tissue is protected while bacteria are killed, and the healing rate of an infected wound is remarkably increased.

The invention discloses a gelatin solution temperature control optimization method for donkey-hide gelatin processing, and belongs to the technical field of swarm intelligence optimization. Comprising the steps that a gelatin solution temperature closed-loop PID control system in the donkey-hide gelatin decocting process is constructed, an improved side hand spider turning optimization algorithm is configured to serve as a parameter setting core, the self-adaptive setting process of PID control parameters is executed, and a global optimal control parameter vector obtained through optimization is mapped to a donkey-hide gelatin solution temperature PID controller module. The method focuses on the PID parameter setting problem of donkey-hide gelatin liquid temperature control, introduces the improved side hand turning spider optimization algorithm as a swarm intelligence algorithm to set the donkey-hide gelatin liquid temperature PID control parameters, and can effectively overcome the defect that the side hand turning spider optimization algorithm is easy to fall into local optimum. And the temperature of the donkey-hide gelatin liquid can be controlled more excellently.

The invention discloses bird's nest composite honey suitable for women. The bird's nest composite honey is prepared from the following raw materials in parts by weight: 1-10 parts of bird's nests, 1-10 parts of ginseng, 1-10 parts of donkey-hide gelatin, 1-10 parts of lucid ganoderma, 1-10 parts of walnuts, 5-50 parts of rhizoma polygonati, 5-50 parts of fingered citron, 5-50 parts of dried orange peel, 5-50 parts of dried ginger, 5-50 parts of raw malt and 700-970 parts of refined brown sugar. The cubilose composite honey suitable for women is prepared by taking refined brown sugar as a main raw material and combining more than ten precious traditional Chinese medicinal materials such as cubilose, ginseng, donkey-hide gelatin, lucid ganoderma, walnuts, rhizoma polygonati, fingered citron, dried tangerine or orange peel, dried ginger and raw malt, has the characteristics of being good in taste, quick to dissolve, easy to absorb, pure in color and luster, sweet and lingering, simple and convenient to brew one cup of one piece of sugar; the traditional Chinese medicine composition is suitable for women with yellow, dark and blood-free faces and less menstruation, can maintain beauty, keep young and improve menstruation, and has an obvious menstruation continuing effect on menopausal groups.

The invention discloses a photo-thermal composite hydrogel patch and a preparation method and application thereof.The hydrogel patch is of a three-dimensional latticed porous structure formed by taking methylacryloyl gelatin (GelMA) and methylacryloyl hyaluronic acid (HAMA) as matrixes, loading niobium carbide nano-particles (Nb2CNPs) and vinipofen (VP) and conducting 3D printing or casting molding, the hydrogel patch is named as VP-Nb2C-coated GelMA / HAMA (VNGH) hydrogel patch for short. The VNGH has good photo-thermal antibacterial property, oxidation resistance and reepithelization promoting function, can significantly improve the quality of mouse diabetic wound healing, and provides a new thought and strategy for realizing scar-free healing of diabetic wounds.

The invention relates to the technical field of dental restoration materials, in particular to a bacteriostatic dental restoration composite film and a preparation method thereof. The oral cavity restoration composite film is composed of an upper-layer antibacterial film, a middle-layer polycaprolactone fiber film and a lower-layer bone restoration film. The upper-layer antibacterial film is prepared from the following components in parts by weight: 3 to 4 parts of cinnamon essential oil, 0.5 to 1 part of xanthan gum, 0.5 to 1 part of seed meal protein, 0.1 to 0.15 part of tannic acid, 5 to 7 parts of silk fibroin, 1 to 1.5 parts of polylactic acid, 0.6 to 1 part of chitosan, 1 to 1.5 parts of polyvinyl alcohol and 1.5 to 2.5 parts of glycerol; the lower-layer bone repair membrane is prepared from the following raw materials in parts by weight: 2 to 3 parts of nano-hydroxyapatite, 3 to 5 parts of citric acid, 6 to 9 parts of lactic acid, 3 to 4 parts of tyrosine, 1 to 2 parts of glycollic acid, 2 to 3 parts of casein, 0.2 to 0.3 part of hyperoside and 1 to 2 parts of gelatin.

The present invention discloses a chitosan-modified highly transparent antibacterial polylactic acid film and a preparation method and application thereof. The polylactic acid film comprises the following raw materials by weight: 10 to 16 parts of modified chitosan, 35 to 55 parts of polylactic acid, 5 to 15 parts of casein, 50 to 300 parts of solvent and 30 to 50 parts of gelatin, wherein the solvent comprises hexafluoroisopropanol and acetic acid solution. The antibacterial polylactic acid film provided by the present invention has good toughness, strength and transparency, is suitable for the field of food packaging, can extend the shelf life of food, and can reduce plastic waste pollution.

The invention relates to the field of veterinary drugs, in particular to a furalan chewable tablet and a preparation method thereof.According to the furalan chewable tablet, a coating agent with xanthan gum, gelatin and other components as main bodies is utilized, the coating performance of the furalan chewable tablet on furalan is improved, and good palatability can be provided on the basis that the whole furalan chewable tablet has good hardness, tablet preparation performance and disintegration performance; the feed is more suitable for animals to eat.

The invention discloses a preparation method of 3, 4-dihydroxy benzaldehyde / gelatin carbon nanomaterial-based adhesive hydrogel, and belongs to the technical field of hydrogel. According to the invention, 3, 4-dihydroxy benzaldehyde and gelatin are adopted as carbon sources, the synthesized nano-filler has amphiphilic surface characteristics, uniform dispersion of the nano-filler in a hydrogel network can be promoted, meanwhile, a mechanically firm and deformable nano-composite structure is established by utilizing the interaction of multivalent interfaces, and 3, 4-dihydroxy benzaldehyde and gelatin are added into the hydrogel network. The surface chemical property of the 1, 4-dihydroxybenzaldehyde / gelatin nano-filler not only can relieve phase separation, but also can promote synergistic energy dissipation through hydrogen bond reconstruction under the action of stress. According to the design, the inherent flexibility of the hydrogel is reserved, meanwhile, the electromechanical response capacity of the hydrogel is greatly improved, and the obtained hydrogel material has the dual functions of structural supporting and active sensing media and can be seamlessly integrated with biological tissue without sacrificing the fidelity of interface signals.

The invention relates to the technical field of microcapsule encapsulation, and a novel preparation method is adopted to prepare microcapsule perfume. The microcapsule takes natural gelatin and paraffin as composite wall materials, a gradient structure is formed by optimizing the mass ratio (1: 2.5-1: 3.75), the gelatin provides mechanical support, and the paraffin endows hydrophobicity and thermal control release characteristics. Dissolving a solution in which the mass volume ratio of gelatin to water is (1: 2.5)-(1: 3) under an ultrasonic condition; mixing the molten paraffin with the liquid spice and the emulsifier to form an oil phase; the oil phase and the gelatin solution are mixed through magnetic stirring at the rotating speed larger than or equal to 800 rpm till the solid phase and the liquid phase are completely fused; after cooling and curing, separating to obtain the solid microcapsule. And when the temperature reaches the melting point (45-65 DEG C) of paraffin, the wall material is molten and quickly releases the perfume, and the slow release performance is excellent at normal temperature. The material is wide in application field and high in compatibility, and has the advantages of being green, safe, high in environmental stability and controllable in trigger release.

The present invention relates to a preparation method of a flame-retardant, high-refractive-index, melt-drop-resistant water-based acrylate resin coating. Water, an emulsifier, and methacrylic acid are added to a reaction vessel and stirred for reaction, and then monomer A, DOPO, and N-vinylcarbazole are added; the temperature is raised to 75-85 °C, an initiator is added dropwise, and the reaction is carried out for 1-2 h to obtain a core-layer emulsion; at the same time, all of monomer B and the initiator are added dropwise, and the reaction is stirred for 1-2 h, then DOPO is added, the temperature is lowered to 50 °C, emulsifier B is added, the reaction time is 30-60 min, then N-vinylcarbazole is added, and the reaction is carried out for 0.25-0.5 h. Then, an ammonium polyphosphate solution, aluminum sulfate, and a chitosan / gelatin composite microsphere are added, and high-speed shear emulsification is carried out, and the pH value is adjusted to 7-8 to obtain a flame-retardant, high-refractive-index, melt-drop-resistant water-based acrylate resin coating; the obtained acrylate resin coating has the advantages of a high oxygen index, no melt dripping during combustion, and a high film refractive index.

The invention relates to the technical field of droplet digital nucleic acid detection and biological materials, in particular to microgel based on acrylic anhydride gelatin and nucleic acid to be detected as well as preparation and application of the microgel. The preparation method comprises the following steps: firstly, dissolving a photoinitiator and acrylic anhydride gelatin, and uniformly mixing to obtain a pre-polymerized solution; uniformly mixing the pre-polymerized solution with a to-be-detected nucleic acid mixed solution to obtain a dispersion phase; oil incompatible with the dispersed phase is used as a continuous phase; building a constant-temperature device, and enabling the dispersed phase to form liquid drops by using a liquid drop microfluidic method; and finally, performing amplification treatment on the liquid drops, and then performing photo-initiation crosslinking to obtain the microgel based on the acrylic anhydride gelatin and the nucleic acid to be detected. The prepared microgel based on the acrylic anhydride gelatin and the nucleic acid to be detected is further applied to detection of target nucleic acid.