2721 results about "Gelatin" patented technology

The invention discloses bone cement for orthopedic repair and a preparation method thereof, and relates to the technical field of bone cement. The bone cement for orthopedic repair comprises solid-phase powder and a liquid-phase component, the solid-phase powder comprises the following components in parts by weight: 55-65 parts of composite calcium phosphate, 10-15 parts of bioactive glass, 2-3 parts of a developing agent, 1-2 parts of hydroxyapatite, 8-12 parts of a modified toughening agent and 2-3 parts of nano cellulose fibers; the liquid phase component is prepared from the following components in parts by weight: 40 to 50 parts of a sodium alginate solution, 10 to 20 parts of methacrylated gelatin, 0.5 to 1 part of transglutaminase, 30 to 60 parts of a citric acid buffer solution and 1 to 2 parts of an antibacterial agent. The preparation method comprises the following steps: reacting pentaerythritol with 12-oxododecanoic acid to obtain an intermediate 1, and reacting the intermediate 1 with dopamine to prepare the modified toughening agent. The bone cement for orthopedic repair prepared by the invention has good mechanical, self-repairing and antibacterial properties.

The invention discloses an intelligent quality inspection system for medicinal empty capsules, particularly relates to the field of intelligent detection, and comprises a multi-dimensional optical characteristic acquisition module, a dynamic thermodynamic response analysis module, a near infrared spectrum component inversion module, a multi-source data fusion decision module and a self-adaptive feedback optimization module. Omnibearing nondestructive detection of the capsule is realized through non-contact multispectral imaging and vibration response analysis, traditional destructive sampling loss is thoroughly avoided, and the multisource data fusion module integrates optical texture features, mechanical frequency domain energy density and near infrared spectrum inversion values based on the D-S evidence theory, so that the detection accuracy is improved. And the self-adaptive optimization module dynamically adjusts an optical wavelength weight, a mechanical sweep frequency range and a spectrum modeling parameter by applying reinforcement learning, is self-adaptive to fluctuation of different batches of gelatin materials and environmental interference, remarkably reduces a misjudgment rate and ensures continuous and stable operation of a production line.

The invention relates to a preparation method and application of a Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair, and the preparation method comprises the following steps: respectively dissolving phenylboronic acid grafted methacrylamide gelatin and dopamine grafted hyaluronic acid in deionized water, adding MXene coated CeO2 heterojunction, and ultrasonically dispersing uniformly, so as to obtain the Janus structure photo-thermal-piezoelectric hydrogel dressing for infected wound repair. After mixing, sodium hydroxide is used for adjusting the pH value to alkalescence, and a Janus structure inner layer is formed; respectively dissolving phenylboronic acid grafted gelatin and o-nitrobenzyl alcohol grafted hyaluronic acid in deionized water, adding BaTiO3, ultrasonically dispersing uniformly, and mixing to form a Janus structure outer layer; the Janus structure photo-thermal-piezoelectric hydrogel dressing prepared by the invention has the characteristic of space-time release so as to adapt to the wound repair process, in addition, the Janus structure photo-thermal-piezoelectric hydrogel dressing also has excellent photo-thermal conversion performance, bacteria infecting the wound are killed through photo-thermal heating, physiological electric signals are effectively simulated through the piezoelectric effect, cell behaviors are regulated and controlled, and the Janus structure photo-thermal-piezoelectric hydrogel dressing can be used for wound infection repair.

The invention discloses a Janus wound dressing with antibacterial and tissue repair promoting functions and a preparation method of the Janus wound dressing, belongs to the technical field of wound dressings, and aims to realize antibacterial, tissue repair promoting and moist wound healing microenvironment through freeze drying and electrostatic spinning technologies. Polycaprolactone (PCL), bioactive glass (BG) and curcumin Cur are used for preparing a hydrophobic inner layer capable of promoting tissue repair, methacrylated gelatin GelMA is used for preparing a hydrophilic outer layer with moisturizing performance, and the PCL-BG-Cur / GelMA composite wound dressing with antibacterial, moisturizing and repair promoting functions is constructed. Animal experiment results show that the dressing loaded with curcumin Cur and bioactive glass BG has multiple functions of synergistic antibiosis, moisturizing and the like, the result shows that the prepared dressing has the performance of promoting epithelization, collagen deposition, new hair follicle formation and the like, and the dressing has a considerable application prospect in the aspect of rapid wound repair.

The invention belongs to the technical field of biology, and discloses a stable protective agent, a cell antigen dry sheet and a preparation method and application of the dry sheet, the stable protective agent comprises glycerin with the volume fraction being 0.4%, gelatin with the mass volume fraction being 0.1%, EDTA with the mass volume fraction being 0.1 mM, trehalose with the mass volume fraction being 0.03% and resveratrol with the mass volume fraction being 100 [mu] M. The stable protective agent is adopted for preparing the cell antigen dry sheet, and the cell antigen dry sheet is applied to CBA detection. The stable protective agent has good permeability, can penetrate through cell membranes to enter cells, provides a protection effect inside and outside the cells, has moisture retention and oxidation resistance, can prevent cell deformation and cell fixing layer shedding, and can well maintain the stability and reliability of antigen proteins, and the prepared cell antigen dry sheet can be stored for a long time, and has a good application prospect. The antigenicity of a membrane signal index is not damaged. When a positive sample is detected, obvious green fluorescence cells can be seen, red fluorescence quenching is avoided, and co-localization of red fluorescence and green fluorescence can be observed conveniently.

The invention relates to a starch-based soft capsule shell and a preparation method thereof. The starch-based soft capsule shell is prepared from the following raw materials in parts by mass: 60 to 70 parts of hydroxypropyl starch, 9 to 20 parts of carrageenan, 5 to 15 parts of diquat, 5 to 15 parts of polylysine, 5 to 10 parts of hydroxypropyl methyl cellulose acetate succinate, 15 to 20 parts of glycerol and 30 to 40 parts of pure water. According to the soft capsule shell, hydroxypropyl starch serves as a base material, gelatin is not added, the conditions of poor weather resistance and fishy smell caused by use of gelatin are avoided, through the synergistic effect of all the components, the defects that a starch-based material is poor in plasticity, fragile and insufficient in mechanical strength are overcome, the structural stability is enhanced through chemical crosslinking, and the mechanical strength is improved; and the mechanical property is improved by virtue of physical compounding, so that the low-temperature resistance, high-temperature resistance and mechanical strength of the capsule skin are improved.

The present invention discloses automated soft capsule production equipment and a speed regulation method, relating to the field of food and pharmaceutical equipment manufacturing, and is designed to achieve automated soft capsule production. The automated soft capsule production equipment includes an electronic control system, a liquid infusion system, a gelatin strip conveyor system, and a soft capsule pressing and molding system. The electronic control system is connected to the liquid infusion system, the gelatin strip conveyor system, and the soft capsule pressing and molding system, respectively. The gelatin strip conveyor system includes a thickness sensor for measuring the thickness of the conveyed gelatin strip and transmitting a measurement signal to the electronic control system. The gelatin strip conveyor system also includes an angle sensor assembly for measuring the tightness of the conveyed gelatin strip and transmitting a measurement signal to the electronic control system. The electronic control system receives and processes the measurement signal and transmits a control signal to a motor in the gelatin strip conveyor system to adjust the thickness or tightness of the gelatin strip. The liquid infusion system automatically closes and opens the infusion switch via the electronic control system, and the soft capsule pressing and molding system automatically controls the mold compression or release via the electronic control system.

The invention discloses an intelligent gradient extraction process and method for nutritional ingredients in yak bone marrow, and belongs to the technical field of bioactive substance extraction. The extraction method comprises the following four steps: gradient pressure supercritical degreasing, double-enzyme synergistic gradient enzymolysis, acid concentration gradient demineralization and temperature gradient gelatin extraction, and through the process coupling design of gradient pressure degreasing, buffer enzymolysis, graded acidolysis and membrane separation of gelatin, the high yield of the product in the previous stage is ensured; active structures of follow-up components are reserved to the greatest extent. Meanwhile, a sensing-decision-execution closed-loop system is constructed, real-time data sources such as NIR moisture sensing, online OPA detection and XRD in-situ analysis are integrated, technological parameters are dynamically adjusted through a multi-objective optimization algorithm, and global optimization of the yield, the purity and the energy consumption is achieved.

The invention relates to the technical field of environmental restoration, in particular to a slow-release material for synergistically restoring heavy metal and organic compound contaminated soil based on modified biochar and microorganisms and an application method thereof.The slow-release material is prepared from, by weight, 50-80 parts of modified biochar, 30-40 parts of sodium alginate, 10-20 parts of gelatin, 5-10 parts of glycerin and 3-5 parts of calcium carbonate. The multi-modified biochar is prepared from, by weight, 300-400 parts of a functional flora mixed solution and 5-10 parts of mixed nutrient elements of glucose, yeast extract and KHPO, and through the synergistic effect of the multi-modified biochar and the functional flora, efficient immobilization (the immobilization rate gt is 60%) of heavy metal (lead, cadmium and chromium) and efficient degradation (the degradation rate gt is 70%) of organic pollutants (polycyclic aromatic hydrocarbon and petroleum hydrocarbon) are achieved.

The invention relates to the technical field of production process intelligent regulation and control, in particular to an intelligent regulation and control method and system for an instant gelatin production process, and the method specifically comprises the following steps: firstly, collecting process parameters such as reaction kettle temperature, acid-base concentration and the like in a production line sensor and control system to form production batch data; then, an optimization model and an intelligent regulation and control strategy are constructed, a dynamic incidence matrix is constructed through time-varying mutual information entropy, multiple types of features are fused to generate a process state descriptor, a constraint dominating relation and a population initialization strategy are optimized, and a self-adaptive genetic manipulation adjustment mechanism and a state-guided search and constraint processing method are designed; iteratively executing an improved NSGA-II algorithm, obtaining an optimized Pareto solution set, and evaluating diversity; and finally, selecting an optimal solution through a multi-criterion decision and a dynamic regulation and control strategy, and converting the optimal solution into an executable process parameter set value. According to the method, the accuracy and the high efficiency of the production process can be improved by realizing intelligent optimization regulation and control of the process parameters.

The invention provides a preparation method of a cell culture three-dimensional scaffold and cell culture meat, which comprises the following steps: firstly, preparing a gelatin-carrageenan mixed solution and a gel precursor solution of transglutaminase, dividing into two parts, incubating at constant temperature to obtain two parts of composite hydrogel, randomly freeze-drying one part to obtain aerogel, and freeze-drying the aerogel to obtain the cell culture three-dimensional scaffold. Stacking on the other part and incubating at constant temperature again to obtain the prefabricated double-layer gel. The prefabricated double-layer gel is directionally frozen, ice crystals grow upwards from the bottom, freezing is stopped after the temperature is reduced to the set temperature, and the cell culture three-dimensional scaffold is obtained through drying. The stent adopts an ordered-disordered partition design, parallel micro-channels are formed in the lower layer by using a directional ice template method, and muscle fiber arrangement is simulated; a porous spongy structure is constructed on the upper layer by using a random ice template method, and is adapted to adipocyte proliferation. Two layers of interfaces are interpenetrated and communicated, natural mechanical gradients are combined, natural tissue characteristics are re-engraved, the traditional limitation is broken through, the cell co-culture efficiency and the cultured meat quality are improved, and industrialization is promoted.

The invention discloses a method for preparing a methylacryloyl chitosan / gelatin-based hydrogel wound dressing through 3D printing and application, and relates to a method for preparing a hydrogel wound dressing and application. The problems that existing MXene is high in photo-thermal conversion temperature, and bacteria rapidly breed again after near-infrared irradiation is closed are solved. The ZGC composite hydrogel wound dressing integrates multiple functions, can simultaneously realize hemostasis, antibiosis, anti-inflammation, vascularization promotion and cell regeneration, and is especially suitable for infectious wounds. The antibacterial performance can be achieved under the activation of near-infrared light through the dual effects of a photothermal therapy and a photodynamic therapy, and meanwhile, the antibacterial effect can be achieved in cooperation with Zn < 2 + >. The ZGC composite hydrogel wound dressing can be accurately customized and printed through a 3D printing technology according to the shape and depth of a wound, the composite dressing can achieve accurate low-temperature photo-thermal treatment, meanwhile, the continuous release of Zn < 2 + > and the physical antibacterial function of MXene are maintained, normal tissue is protected while bacteria are killed, and the healing rate of an infected wound is remarkably increased.

The invention discloses a gelatin solution temperature control optimization method for donkey-hide gelatin processing, and belongs to the technical field of swarm intelligence optimization. Comprising the steps that a gelatin solution temperature closed-loop PID control system in the donkey-hide gelatin decocting process is constructed, an improved side hand spider turning optimization algorithm is configured to serve as a parameter setting core, the self-adaptive setting process of PID control parameters is executed, and a global optimal control parameter vector obtained through optimization is mapped to a donkey-hide gelatin solution temperature PID controller module. The method focuses on the PID parameter setting problem of donkey-hide gelatin liquid temperature control, introduces the improved side hand turning spider optimization algorithm as a swarm intelligence algorithm to set the donkey-hide gelatin liquid temperature PID control parameters, and can effectively overcome the defect that the side hand turning spider optimization algorithm is easy to fall into local optimum. And the temperature of the donkey-hide gelatin liquid can be controlled more excellently.

The invention discloses a photo-thermal composite hydrogel patch and a preparation method and application thereof.The hydrogel patch is of a three-dimensional latticed porous structure formed by taking methylacryloyl gelatin (GelMA) and methylacryloyl hyaluronic acid (HAMA) as matrixes, loading niobium carbide nano-particles (Nb2CNPs) and vinipofen (VP) and conducting 3D printing or casting molding, the hydrogel patch is named as VP-Nb2C-coated GelMA / HAMA (VNGH) hydrogel patch for short. The VNGH has good photo-thermal antibacterial property, oxidation resistance and reepithelization promoting function, can significantly improve the quality of mouse diabetic wound healing, and provides a new thought and strategy for realizing scar-free healing of diabetic wounds.

The invention relates to the field of veterinary drugs, in particular to a furalan chewable tablet and a preparation method thereof.According to the furalan chewable tablet, a coating agent with xanthan gum, gelatin and other components as main bodies is utilized, the coating performance of the furalan chewable tablet on furalan is improved, and good palatability can be provided on the basis that the whole furalan chewable tablet has good hardness, tablet preparation performance and disintegration performance; the feed is more suitable for animals to eat.

The invention relates to the technical field of microcapsule encapsulation, and a novel preparation method is adopted to prepare microcapsule perfume. The microcapsule takes natural gelatin and paraffin as composite wall materials, a gradient structure is formed by optimizing the mass ratio (1: 2.5-1: 3.75), the gelatin provides mechanical support, and the paraffin endows hydrophobicity and thermal control release characteristics. Dissolving a solution in which the mass volume ratio of gelatin to water is (1: 2.5)-(1: 3) under an ultrasonic condition; mixing the molten paraffin with the liquid spice and the emulsifier to form an oil phase; the oil phase and the gelatin solution are mixed through magnetic stirring at the rotating speed larger than or equal to 800 rpm till the solid phase and the liquid phase are completely fused; after cooling and curing, separating to obtain the solid microcapsule. And when the temperature reaches the melting point (45-65 DEG C) of paraffin, the wall material is molten and quickly releases the perfume, and the slow release performance is excellent at normal temperature. The material is wide in application field and high in compatibility, and has the advantages of being green, safe, high in environmental stability and controllable in trigger release.

The invention relates to the technical field of droplet digital nucleic acid detection and biological materials, in particular to microgel based on acrylic anhydride gelatin and nucleic acid to be detected as well as preparation and application of the microgel. The preparation method comprises the following steps: firstly, dissolving a photoinitiator and acrylic anhydride gelatin, and uniformly mixing to obtain a pre-polymerized solution; uniformly mixing the pre-polymerized solution with a to-be-detected nucleic acid mixed solution to obtain a dispersion phase; oil incompatible with the dispersed phase is used as a continuous phase; building a constant-temperature device, and enabling the dispersed phase to form liquid drops by using a liquid drop microfluidic method; and finally, performing amplification treatment on the liquid drops, and then performing photo-initiation crosslinking to obtain the microgel based on the acrylic anhydride gelatin and the nucleic acid to be detected. The prepared microgel based on the acrylic anhydride gelatin and the nucleic acid to be detected is further applied to detection of target nucleic acid.

The invention provides a sustained-release microneedle for treating ill-conditioned pregnancy and a preparation method and application thereof, and relates to the technical field of biological medicines.The sustained-release microneedle for treating ill-conditioned pregnancy comprises a base and a needle tip on the base, the needle tip part of the gel microneedle is made of heparin medicine, and the needle tip part of the gel microneedle is made of gelatin. The heparin medicine comprises heparin, heparin sodium, low-molecular heparin, low-molecular heparin sodium or low-molecular heparin calcium; the needle point part comprises a heparin photo-crosslinking monomer, and the base comprises a biocompatible polymer matrix. The sustained-release microneedle for treating pathological pregnancy provided by the embodiment of the invention has good mechanical strength, skin permeability and anticoagulant activity, can reduce skin bruises caused by subcutaneous injection of heparin, improves abortion caused by infection and inflammation and abortion caused by APS (anti-phospholipid antibody syndrome), can realize sustained release of drugs and increase of drug loading capacity, and has good application prospects. Sustainable drug delivery is achieved, and frequent injection is avoided.

The invention belongs to the technical field of dressing preparation, and particularly relates to a preparation method of a photocuring methacrylated gelatin hydrogel dressing, which comprises the following steps: step 1, dissolving methacrylated gelatin in a phosphate buffer solution to prepare a methacrylated gelatin solution with the mass concentration of 5-15%; 2, adding a natural photoinitiator into the solution obtained in the step 1, and uniformly stirring and mixing; 3, adding the traditional Chinese medicine active ingredient powder, and stirring until the powder is uniformly dispersed to obtain a mixed solution; and 4, pouring the mixed solution into a mold, and curing and molding under the irradiation of visible light. Chlorophyll or riboflavin is used as a natural photoinitiator and is directly dispersed in a methacrylated gelatin solution in a physical blending mode, a curing light source enables chlorophyll to completely avoid a chemical initiator, meanwhile, the process is simplified into physical stirring to replace nanoparticle synthesis and modification, visible light reduces the risk of tissue burn, the production cost is reduced, and the method is suitable for industrial production. The method is suitable for primary medicine.

The invention belongs to the technical field of biomedical anti-inflammatory gels, and discloses a renewable boundary lubrication natural polyphenol anti-inflammatory hydrogel and a preparation method and application thereof.The hydrogel is of a hydrophilic viscoelastic sea island structure, gallic acid grafted gelatin blended with hyaluronic acid serves as a base material, celecoxib lipidosome is entrapped in the hydrogel, and the hydrogel is prepared from natural polyphenols, an articular cavity is injected through an enzyme crosslinking technology to form gel, hyaluronic acid and lipidosome form a hydrated lubricating layer on a cartilage-gel interface, and after the interface is abraded, internal lipidosome and hyaluronic acid are exposed to supplement lubrication so as to form sustainable lubrication; the liposome responds to friction shear crushing to release celecoxib and cooperates with gallic acid at an interface to resist inflammation progress and repair cartilage, the injectable hydrogel is developed based on gallic acid, hyaluronic acid, gelatin and celecoxib liposome to treat early osteoarthritis, mechanical lubrication and inflammation resistance are combined, and the preparation method has the advantages that the preparation method is simple, the preparation cost is low, and the application prospect is wide. The problems of large-dose toxicity, short lubrication period and the like caused by independent treatment are effectively solved, and the preparation has important clinical application significance.

The invention relates to a content determination method of a traditional Chinese medicine composition fingered citron drink. The traditional Chinese medicine composition is prepared from the following medicinal raw materials: fingered citron, orange peel, malt, liquorice, Chinese date, purple perilla, citron, almond and donkey-hide gelatin. The content determination method comprises the following steps: preparing a reference solution and a test solution; detecting the reference substance solution and the test solution by high performance liquid chromatography; a mobile phase adopted by the high performance liquid chromatography is an acetonitrile and formic acid aqueous solution, and the elution mode is gradient elution. According to the content determination method, the content of various components can be simply, conveniently and rapidly determined, and richer chemical information and more comprehensive basis are provided for quality evaluation of the components.

The invention relates to conductive silk fibroin loaded methacrylated gelatin hydrogel and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: S1, adding silk fibroin fibers into a dopamine hydrochloride solution, stirring, standing, then adjusting the pH value to 8-9, and carrying out a heating reaction to obtain polydopamine grafted silk fibroin fibers; s2, sequentially dipping the polydopamine grafted silk fibroin fibers in an ammonium persulfate solution and a pyrrole solution to obtain conductive silk fibroin fibers; and S3, adding the conductive silk fibroin fibers into the methacrylated gelatin solution, carrying out ultraviolet light cross-linking curing, and then soaking the conductive silk fibroin fibers in a glycerol solution to obtain the conductive silk fibroin loaded methacrylated gelatin hydrogel. The method not only can ensure the structural integrity and conductive continuity of a conductive network in the hydrogel, but also breaks through the dependence of in-situ polymerization on the permeability of a matrix.

The invention relates to the technical field of electrolytic copper foil processing, and particularly provides a method for reducing the rough surface roughness of an HVLP copper foil by using a composite additive, which comprises the following steps: step (1): enabling the composite additive to flow into a high-level tank through an additive flow pump, uniformly mixing the composite additive with a copper sulfate electrolyte, and enabling the mixture to flow into a crude foil machine; step (2), then adjusting process parameters of a crude foil machine, including current and line speed of a cathode roller; (3) foil generation and foil drawing are carried out; the composite additive comprises one or two of gelatin and collagen. One or more composite additives composed of gelatin, collagen, sodium dithiodipropane sulfonate, N, N-dimethyl-dithioformamide sodium propanesulfonate, 3-sulfydryl-1-sodium propane sulfonate, hydroxyethyl cellulose and polyethylene glycol are added into the raw foil electrolyte, so that the copper electrodeposition reaction potential can be effectively changed; and uniform and compact copper crystallization peaks are obtained, the rough surface roughness of the raw foil is reduced, and the uniformity of a plating layer is improved.

The invention provides a wound dressing for diminishing inflammation, easing pain and promoting wound healing and a preparation method thereof. The wound dressing capable of diminishing inflammation, easing pain and promoting wound healing is prepared from the following components in parts by mass: 6 to 10 parts of oxidized sodium alginate, 7 to 9 parts of hydrazide gelatin, 1 to 1.5 parts of tannic acid, 8 to 12 parts of polyethylene glycol, 0.05 to 0.1 part of cannabidiol, 0.05 to 0.1 part of neomycin sulfate, 0.2 to 0.3 part of 2-roots alcohol, 0.02 to 0.04 part of vitamin C palmitate and 0.03 to 0.1 part of epsilon-polylysine. The dressing can achieve excellent effects of diminishing inflammation, easing pain and promoting wound healing through synergistic cooperation of all the components.

The invention belongs to the technical field of coating compositions. The invention provides environment-friendly water-based paint with high wear resistance and a preparation method of the environment-friendly water-based paint. The water-based paint is prepared from the following raw materials in parts by weight: 80 parts of waterborne polyurethane, 7-10 parts of modified montmorillonite, 1 part of a dispersing agent, 8-12 parts of microcapsules and 80 parts of water, the modified montmorillonite is obtained by modifying montmorillonite by adopting chitosan; the wall material of the microcapsule is composed of gelatin and carrageenan according to the weight ratio of 3: 1; a core material of the microcapsule is composed of castor oil and linseed oil according to the weight ratio of 2: 1. The water-based paint disclosed by the invention has excellent wear resistance on the basis of having excellent optical performance, mechanical performance, liquid resistance and self-repairing performance at the same time. The light transmittance of the obtained water-based paint reaches 95% or above, the hardness is 4H, the adhesive force is grade 0, the liquid resistance is grade 1, and the maximum mass loss of a paint film per 100 turns is only 12.0 g.

The preparation method specifically comprises the following steps: sequentially adding arginine and lipoic acid into a gelatin solution to obtain a hydrogel pre-polymerized solution; heating the hydrogel prepolymerization liquid to initiate a lipoic acid ring-opening polymerization cross-linking reaction, and adding a poly (3, 4-ethylenedioxythiophene) dispersion liquid modified by polydopamine to obtain gelatin / polylipoic acid conductive hydrogel; the preparation method comprises the following steps: heating and melting a lipoic acid monomer, then adding a cross-linking agent for reaction, then adding metal salt for stirring, and pouring the obtained yellow transparent liquid on the surface of the gelatin / polylipoic acid conductive hydrogel to obtain the double-layer heterogeneous biological adhesive. The invention also discloses an application of the double-layer heterogeneous biological adhesive in a biomedical adhesive. According to the method, strong interface connection between the two layers is achieved through the similar compatibility principle and the hot melting pouring technology, and layering is avoided during use; and the prepared adhesive has good tissue adhesion, self-repairing performance and biocompatibility.

The invention discloses a piezoelectric double-network hydrogel coating modified titanium material and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The piezoelectric double-network hydrogel coating modified titanium material provided by the invention comprises a titanium substrate, an adhesion layer and a piezoelectric double-network hydrogel coating, wherein the adhesion layer and the piezoelectric double-network hydrogel coating are compounded on the titanium substrate; the adhesion layer is compounded on the titanium substrate, and the adhesion layer is positioned between the titanium substrate and the piezoelectric double-network hydrogel coating; and the piezoelectric double-network hydrogel coating is prepared from methacrylic acid modified gelatin, sodium alginate and whitmanite nanoparticles. According to the prepared modified titanium material, electric signals can be generated on the surface of the piezoelectric material under the action of polarization or stress, recovery of charge transfer of a bone defect part is facilitated, a good electroactive microenvironment is created for bone regeneration, the osseointegration capacity of the modified titanium material is enhanced, and bone regeneration is effectively promoted; the method has a wide application prospect in preparation of bone graft materials and bone repair materials.

The invention belongs to the technical field of fire-extinguishing building materials, and discloses a microencapsulated efficient automatic fire-extinguishing patch and a preparation method thereof.The fire-extinguishing patch contains a fire-extinguishing microcapsule, the fire-extinguishing microcapsule is of a double-layer structure, the inner layer contains gelatin, kaolin, perfluorohexanone, sodium hexametaphosphate, resorcinol and glutaraldehyde, and the outer layer contains gelatin, kaolin, perfluorohexanone, sodium hexametaphosphate, resorcinol and glutaraldehyde; and the outer layer comprises a vinylidene fluoride-acrylic acid copolymer and glutaraldehyde. According to the invention, the flaky kaolin is used for enhancing the formaldehyde-free phenolic aldehyde inner layer and the vinylidene fluoride-acrylic acid copolymer outer layer to form a double-layer shell layer with high air tightness, so that the compactness and long-term stability of the shell layer of the microcapsule are greatly improved.

The present invention pertains to the technical field of materials. Disclosed are a polymer composite hydrogel and a preparation method therefor, and a tooth desensitization material. The polymer composite hydrogel consists of a GelMA hydrogel and BP nanosheets composited inside the GelMA hydrogel, wherein the GelMA hydrogel is prepared by crosslinking gelatin methacryloyl via double bonds under the action of a photoinitiator. Under the photothermal effect, the polymer composite hydrogel of the present invention can enhance the resistance of dentin to external stimuli and promote the formation of stable and effective occlusion of dentinal tubules. Moreover, the occlusion effect on the dentinal tubules exhibits acid resistance, corrosion resistance, and stability, preventing the possibility of short-term reopening of the occluded dentinal tubules. This is of great significance for the treatment of occluded dentin hypersensitivity (DH).

The invention discloses ternary synergistic nano-enzyme hydrogel as well as a preparation method and application thereof, and relates to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving zinc nitrate hexahydrate and ferric nitrate nonahydrate in methanol; dissolving 2-methylimidazole in methanol, adding into a metal salt solution, stirring, and sequentially centrifuging, washing and drying to obtain Fe / ZIF-8 nano-enzyme; the preparation method comprises the following steps: adding methacrylated gelatin and hyaluronic acid into deionized water, stirring, cooling to room temperature, and refrigerating to obtain a GelMA-HA precursor solution; and adding the Fe / ZIF-8 nano-enzyme into the GelMA-HA precursor solution, stirring, injecting into a mold, and carrying out ultraviolet light cross-linking curing to obtain the ternary synergistic nano-enzyme hydrogel. According to the hydrogel disclosed by the invention, active oxygen is efficiently removed and oxygen is produced through Fe / ZIF-8 nano-enzyme, and cartilage repair is promoted in combination with lubrication and slow release functions of gelatin hydrogel, so that a new strategy is provided for treatment of osteoarthritis.