649 results about "Chlorogenic acid" patented technology

The invention provides a metal polyphenol nanoparticle, a preparation method thereof and an application of the metal polyphenol nanoparticle in preparation of a medicine for treating acute lung injury, the metal polyphenol nanoparticle is formed by self-assembly of metal ions and polyphenol, the metal ions are selected from Mg < 2 + >, Zn < 2 + >, Mn < 2 + > or Cu < 2 + >, and the polyphenol is selected from Mg < 2 + >, Zn < 2 + >, Mn < 2 + > or Cu < 2 + >. The polyphenol is selected from epigallocatechin gallate (EGCG), caffeic acid (CA), chlorogenic acid (CGA), gallic acid (GA) and luteolin (LUT). The metal polyphenol nanoparticles are used for preparing a medicine for treating acute lung injury induced by sepsis, pneumonia, serious trauma or inhalation injury, and the medicine further comprises a pharmaceutically acceptable carrier. The metal polyphenol nanoparticles provided by the invention are simple in preparation process and high in biological safety, polyphenol and metal ions synergistically enhance the anti-inflammatory and antioxidant activity, and the metal polyphenol nanoparticles are superior to the single use of polyphenol or metal ions.

The invention discloses a bamboo powder-containing biodegradable plastic for food contact and a preparation method thereof, and relates to the technical field of bio-based materials. The bamboo powder-containing biodegradable plastic for food contact comprises chitosan starch and modified bamboo powder, the chitosan starch is prepared by adding composite chitosan and amino-terminated polyethylene glycol into oxidized corn starch, and the composite chitosan is prepared by grafting chlorogenic acid on the surface of chitosan and then coating succinic anhydride derivatives. The succinic anhydride derivative is prepared from dodecenyl succinic anhydride and 1, 4-butanediamine through a reaction, so that the plastic has the antibacterial property, and meanwhile, the mechanical property is enhanced; the modified bamboo powder is prepared by reacting bamboo powder with a carboxyl-terminated composition, and the carboxyl-terminated composition comprises carboxyl-terminated polylactic acid and carboxyl-terminated polyamide. The toughness of the plastic is enhanced, and the mechanical property of the plastic is further enhanced.

The invention discloses a hydrogel dressing with a double-slow-release effect as well as a preparation method and application of the hydrogel dressing. The preparation method of the hydrogel dressing comprises the following steps: firstly, preparing methyl acrylate modified hyaluronic acid capable of being photo-crosslinked, then preparing carboxymethyl chitosan nanoparticles loaded with chlorogenic acid, and finally, mixing the methyl acrylate modified hyaluronic acid and the carboxymethyl chitosan nanoparticles loaded with chlorogenic acid to obtain the hydrogel dressing. The hydrogel dressing embedded with the nanoparticles is obtained in a photo-crosslinking mode. The hydrogel dressing provided by the invention not only has good biocompatibility and mechanical properties, but also plays an anti-oxidation role by removing free radicals in a body, and can effectively kill bacteria such as escherichia coli and staphylococcus aureus to play an antibacterial role. The hydrogel dressing can also reduce excessive inflammatory response in the wound healing process by influencing macrophage polarization, promote chronic wound healing and relieve pain of patients.

The invention provides a plant lactobacillus TH13, and the preservation number of the plant lactobacillus TH13 is CGMCC (China General Microbiological Culture Collection Center) NO.32112. The plant lactobacillus TH13 provided by the invention can be used for fermenting folium cortex eucommiae and enzymatically hydrolyzed bone meal, and the fermentation product of the plant lactobacillus TH13 has high content of chlorogenic acid, proline, glycine and lysine. The fermentation product can significantly improve the content of alkaline phosphatase (ALP) and osteocalcin (OCN) in mouse serum and reduce the content of tartrate-resistant acid phosphatase (TRACP). Therefore, the fermentation product can significantly improve the bone mineral density of the femur, increase the number of bone trabecula and significantly reduce the separation degree of the bone trabecula, thereby promoting bone formation of a mouse with senile osteoporosis, inhibiting bone resorption and improving senile bone loss and bone microstructure deterioration. The preparation method of the probiotic preparation containing the plant lactobacillus and the probiotic fermentation product is simple, and large-scale production can be realized.

The invention relates to screening and application of a Candida antarctica lipase B mutant. Specifically, the Candida antarctica lipase B mutant provided by the invention is obtained by carrying out rational design and directed evolution combined strategy mutation on the basis of a wild Candida antarctica lipase B gene sequence, and the amino acid sequence of the mutant is shown as SEQ ID NO.3. The invention also relates to a preparation method of the Candida antarctica lipase B mutant. The mutant has higher enzyme activity and thermal stability, the hydrolytic catalytic activity of the mutant is improved to 2.1 times of the original hydrolytic catalytic activity, and the half-life period of the mutant enzyme at 50 DEG C is prolonged by 4 times. On the basis, pichia pastoris is used as a host to express the mutant, and a strain with hydrolytic activity improved by 52% is obtained through high resistance screening. The lipase is prepared into an immobilized enzyme to be used in a synthetic reaction of chlorogenic acid derivatives, the highest conversion rate of chlorogenic acid reaches 74% in 24 hours, and the immobilized enzyme has a good industrial application prospect.

The invention relates to the technical field of biological materials, in particular to silver nano-chlorogenic acid composite hydrogel as well as preparation and application thereof. According to the invention, the CGA and the silver nitrate are used for green synthesis of the nano-particles CGA-AgNPs, and the nano-particles have peroxide nano-enzyme activity and antibacterial activity; and the CGA-AgNPs and chitosan (CS) are cross-linked to form the silver nano-chlorogenic acid composite hydrogel CGA-AgNPs-CS, so that the uniform distribution of nano-particles in the hydrogel can be promoted. According to the invention, multi-functionalization is taken as a target, a novel hydrogel composition system is designed from the source, the provided preparation method is green, simple, rapid and environment-friendly, the obtained composite hydrogel has multiple functions, and a good foundation is laid for expansion and application of the composite hydrogel in the biomedical fields of wound repair, wearable equipment, nano antibacterial drugs and the like.

The invention discloses a mucosal epithelial cell targeted oral ROS response type nano-enzyme as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The oral ROS response type nano-enzyme comprises Ce-CDs carbon dots and a betaine polymer, and the betaine polymer is coated on the surfaces of the Ce-CDs carbon dots to form nano-particles; the Ce-CCDs carbon dots are prepared by taking a metal cerium source and chlorogenic acid as raw materials through a pyrolysis method. Through structural innovation and function integration, the prepared nano-enzyme shows outstanding advantages in the aspects of catalytic activity, targeted delivery, collaborative treatment, industrial application and the like, a new technical scheme is provided for efficient and safe treatment of inflammatory bowel diseases, and the nano-enzyme has remarkable technical innovation and clinical application value.

The invention provides a sarcandra glabra and honeysuckle compound preparation and a preparation method thereof, and during preparation, part of sarcandra glabra and honeysuckle are subjected to supercritical carbon dioxide extraction, volatile oil and medicine residues are collected, and the medicine residues and the rest of sarcandra glabra and honeysuckle are subjected to water extraction. A proper amount of beta-cyclodextrin is added into a water extract for inclusion, then concentration and supercritical extraction are performed to obtain volatile oil, and beta-cyclodextrin is used for inclusion, so that on the basis of increasing the efficacy of the volatile oil, the contents of chlorogenic acid and isofraxidin are increased, the curative effect of the medicine is enhanced, the synergistic effect of all components of the medicine is exerted, and the treatment effect of the medicine is improved. Menthol is clathrated with beta-cyclodextrin and then added into the paste powder to be mixed, granulated and tableted. On the premise of not influencing the dissolution of menthol and the direct stimulation effect on the throat, the effects of dispelling wind, clearing heat, relieving sore throat and relieving pain of the medicine are further enhanced, and meanwhile the problems that the quality of the product is not stable enough due to environmental change during storage, menthol is volatilized and is easy to crystallize, separate out and deteriorate are effectively solved.

The invention discloses a metal polyphenol nano material based on chlorogenic acid and a preparation method and application thereof.The preparation method comprises the steps that chlorogenic acid and distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 are mixed and dissolved in an anhydrous tetrahydrofuran solvent, and a first mixed solution is prepared; adding a FeCl3 solution into the first mixed solution until a clear and transparent system is formed, so as to obtain a second mixed solution; and removing the anhydrous tetrahydrofuran solvent of the second mixed solution to obtain the metal polyphenol nano material (CA-Fe NPs) based on chlorogenic acid. The metal polyphenol nano material has excellent photothermal conversion performance, and can be applied to in-vitro antibiosis, antioxidation, anti-inflammation and wound healing promotion.

The invention relates to the technical field of preparation methods of giant salamander peptide and eucommia ulmoides male flower tablets, in particular to a preparation method of giant salamander peptide and eucommia ulmoides male flower tablets. The giant salamander peptide and eucommia ulmoides male flower tablets comprise the following raw materials in parts by weight: 30-40 parts of giant salamander peptide powder, 20-25 parts of eucommia ulmoides male flowers, 10-15 parts of rape pollen, 10-15 parts of sea cucumber intestine peptide powder, 10-12 parts of a filler, 3-5 parts of an adhesive and 1-3 parts of a lubricant. According to the invention, the eucommia male flower contains geniposidic acid, chlorogenic acid, aucubin lignin, iridoid and phenylpropanoid natural active nutrient substances, flavonoid compounds, polysaccharide and other bioactive substances in the rape pollen, polysaccharide and peptide components in the sea cucumber intestine peptide powder, and the like. The andrias davidianus peptide powder is added into the andrias davidianus peptide powder, the andrias davidianus peptide powder cooperates with antioxidant peptide and immunomodulatory peptide in the andrias davidianus peptide powder to jointly form a rich bioactive substance library, and the components regulate the physiological functions of the human body from different angles, provide comprehensive nutrition support for the body and improve the fatigue resistance of the human body.

The composition is of a network structure and is composed of strontium ions and chlorogenic acid, and the weight ratio of the strontium ions to the chlorogenic acid is 1: (9-11). The composition and hydrogel are mixed to prepare a microneedle patch, and the microneedle patch is prepared into a medical instrument for wound repair. Through verification, the SrC-MPNs is continuously released by the SrC-MPNs (at) MN-PP, so that the substances are dissolved and absorbed into tissue fluid around a wound, and strontium ions and chlorogenic acid in the SrC-MPN can stably and continuously exert the effects of resisting bacteria and oxidation, promoting angiogenesis, promoting wound healing and the like. An in-vivo experiment result shows that the SrC-MPNs (at) MN-PP can promote in-vivo and in-vitro wound healing, promote M2 macrophage polarization, remove excessive ROS and promote angiogenesis and tissue regeneration so as to promote healing of diabetic wounds.

A preparation method of a polyester nanofiltration membrane with high chlorine resistance and pollution resistance relates to the technical field of chlorine-resistant polyester nanofiltration membranes, and comprises the following steps: sequentially dipping a polyacrylonitrile support layer in an aqueous phase solution and an oil phase solution, carrying out condensation polymerization at 25-45 DEG C to generate a polyester selection layer on the surface, and finally heating and crosslinking at 45-65 DEG C to obtain the polyester nanofiltration membrane. The aqueous phase solution is a tannic acid aqueous solution, a rhamnose aqueous solution, a vitamin C aqueous solution or a chlorogenic acid aqueous solution, the preparation method is simple and low in cost, and the formed polyester nanofiltration membrane has high chlorine resistance and pollution resistance.

The invention discloses a morchella esculenta extract as well as an extraction method and application thereof, and belongs to the technical field of plant medicine product separation. The invention relates to a specific extraction method of phenolic acid of morchella, through the synergistic effect of low-temperature plasma pretreatment, targeted enzymolysis and deep eutectic solvent extraction, the extraction rate of phenolic acid is remarkably improved, particularly, specific extraction of chlorogenic acid can be realized, and the purity of chlorogenic acid is greater than 85%. The process is environment-friendly and efficient, and the obtained product has important application value in the fields of inflammation resistance and oxidation resistance.

The invention discloses a plant cell activating factor as well as a preparation method and application thereof. The plant cell activating factor contains active ingredients such as resveratrol, quercetin, chlorogenic acid and the like. The active ingredients of the plant cell activating factor are obtained from natural plants, so that the plant cell activating factor has no pollution to the environment, is safe and harmless to human bodies and animals, and meets the requirements of green agricultural development. Experiments prove that the plant cell activating factor disclosed by the invention can effectively regulate the physiological activity of plant cells, activate the growth potential of plants, promote the development of plant root systems, thick and strong stalks and dark green leaves, and remarkably improve the growth speed and biomass accumulation of the plants, thereby increasing the yield of crops.

The invention discloses a preparation method and application of a composite probiotic preparation which has a fat reducing function and comprises Lactobacillus rhamnosum D8A, and belongs to the technical field of probiotics. The probiotics can inhibit the growth of obesity-related pathogenic bacteria lactobacillus cloacae, and the content of chlorogenic acid and polysaccharide is remarkably increased through specific fermentation of honeysuckle. The extracted polysaccharide shows fat-reducing activity through verification of a 3T3-L1 cell model, and animal experiments show that the effect of the probiotic preparation prepared based on the polysaccharide embedding technology developed on the basis is obviously better than that of other preparations. The invention provides an innovative solution for developing a fat-reducing probiotic preparation, and has important application value in the fields of functional food and weight management.

The invention discloses a preparation method of a fermented coffee pericarp fruit juice beverage. The coffee pericarp and the fruit juice are used as raw materials and are sequentially fermented by two strains, so that on the premise that the content of chlorogenic acid in the beverage is relatively high, the acerbity of the coffee pericarp is reduced, and the content of flavor substances with fruit flavor, flower flavor and the like is increased, so that the beverage not only has rich coffee flavor and fruit flavor, but also has soft ethanol flavor; the coffee pericarp is mellow and smooth in taste, meets diversified taste requirements of consumers, and provides a new thought for further development and utilization of coffee pericarp.

According to the dry fish maw capable of inhibiting fat oxidation and the preparation method thereof, fresh air bladders are soaked in a lactic acid bacteria solution, then subjected to anti-oxidation treatment with a chlorogenic acid solution, soaked in alkali liquor and dried, and the dry fish maw capable of inhibiting fat oxidation is obtained. Lactobacillus treatment and chlorogenic acid anti-oxidation treatment are combined, alkali is used for neutralizing generated acidic substances, natural substances are used for treatment, harmful compounds are not introduced, and the eating risk is reduced. Moreover, the yellowness value can be effectively reduced, the increase of POV value and TBA value is inhibited, the rancidity and rancidity of the dried fish maw are reduced, and long-time storage is facilitated. The preparation process is green and safe, short in treatment time and suitable for industrial production of dried fish maw.

The invention discloses a preparation method and application of a chlorogenic acid carbon quantum dot microsphere capsule, a natural active product chlorogenic acid (CHA) in coffee is used as a raw material, and chlorogenic acid carbon quantum dots (CHA CDs) with anti-inflammatory and antioxidant activity are synthesized through a hydration method; then, the chlorogenic acid carbon quantum dots (CHACDs) are packaged with chitosan, and meanwhile, the chitosan on the outer layer of the capsule is modified with the DNA aptamer, so that the chlorogenic acid carbon quantum dot microsphere capsule Apt-CS (at) CHA CDs are obtained. The chlorogenic acid carbon quantum dot microsphere capsule disclosed by the invention not only has anti-inflammatory and antioxidant activity, but also can regulate intestinal flora, enhance intestinal barrier function and immune conditions; moreover, the microsphere capsule can be retained in the intestinal tract for a long time, so that the microsphere capsule can resist inflammation and remove high-level reactive oxygen species (ROS), can be retained in the intestinal tract for a long time and play a role in regulating intestinal flora, finally, the disease development of IBS is comprehensively relieved, and the microsphere capsule has a very good application prospect.

The invention relates to the technical field of antibacterial agents, in particular to a compound antibacterial agent of a plant polyphenol complex and a preparation method of the compound antibacterial agent. The compound antibacterial agent is prepared from the following raw materials in parts by weight: 20-30 parts of moutan bark extract, 20-30 parts of folium mori, 20-30 parts of a carrier, 10-20 parts of jerusalem artichoke extract, 10-20 parts of coptis chinensis extract, 2-4 parts of a tackifier and 1-3 parts of a microbial agent. According to the invention, paeonol in moutan bark, chlorogenic acid in mulberry leaves, berberine in coptis chinensis and inulin polyphenol in jerusalem artichoke can be combined with lipid of bacterial cell membranes, so that membrane permeability is increased, microbial metabolic enzymes are interfered, energy metabolism and biosynthesis are blocked, free radicals are removed, and antibacterial effects of other components are enhanced; folium mori is hydrolyzed through beta-glucosidase to release free polyphenol, gluconolactone adjusts the acid environment to promote polyphenol dissolution, and the antibacterial effect of the composite antibacterial agent is effectively improved.

The invention provides a combined lactobacillus salivarius YS-UR90 and a preparation method of the combined lactobacillus salivarius YS-UR90. The saliva combined lactobacillus provided by the invention can secrete protease and glycosidase, and the HCT and FLS gene expression levels of the saliva combined lactobacillus are high, so that the saliva combined lactobacillus can promote phenolic acid active ingredients to generate biotransformation during fermentation, and the proportion of chlorogenic acid and the like in fermentation liquor is increased. For example, marine fish oligopeptide and casein phosphopeptides are used as a composite nitrogen source, dandelion powder is used as a functional substrate, and a composite fermentation product obtained through fermentation of saliva and lactobacillus has the effect of promoting uric acid excretion and has a certain protection effect on kidney injury. The compound fermentation product has the effect of improving hyperuricemia mainly by inhibiting XOD activity, increasing serum urea nitrogen level, improving defect expression of uric acid synthesis gene HPRT1, inhibiting expression of uric acid reabsorption URAT1 and GLUT9 genes and improving expression of excretion genes OAT1 and ABCG2.

The invention relates to the technical field of fertilizers, and provides a pollen polysaccharide-based water-soluble fertilizer and a preparation method thereof. The water-soluble fertilizer is prepared from the following components in percentage by mass: 14 to 40 percent of chemical fertilizer, 6 to 10 percent of vegetable protein-based pollen polysaccharide temperature-sensitive hydrogel, 0.1 to 0.5 percent of chlorogenic acid, 1 to 5 percent of humic acid and the balance of water. According to the invention, the pollen polysaccharide is wrapped by the vegetable protein to prepare the temperature-sensitive hydrogel, and the pollen polysaccharide is isolated from inorganic salt in the water-soluble fertilizer; then a stronger hydrogen bond network and electrostatic interaction are formed by carboxyl and multiple hydroxyls in chlorogenic acid molecules, pollen polysaccharide and vegetable protein, so that the stability and the uniform dispersity of a hydrogel system are remarkably improved. The combination of the two improves the flowability of the fertilizer, avoids layering, improves the system consistency during spraying or application, and improves the fertilizer efficiency.

The invention belongs to the technical field of medicines, and provides application of a natural-source compound monomer medicine composition in preparation of medicines for preventing and / or treating pancreatitis. The pharmaceutical composition comprises baicalin, paeoniflorin, geniposide, wogonin, baicalein, albiflorin, tetrahydropalmatine, rhein, wogonin, aloe-emodin, saikoside A, emodin, benzoyl paeoniflorin, chlorogenic acid, costunolide, or a pharmaceutically acceptable salt thereof. Compared with the prior art, the pharmaceutical composition disclosed by the invention has the advantages that the components of the composition are definite and are all natural sources, the safety is good, the pharmaceutical effect has a remarkable synergistic effect, the administration dosage is reduced by about 200 times under the condition that the treatment effect is better than that of a compound traditional Chinese medicine, the administration mode of the compound medicine for treating pancreatitis is innovated, and the pharmaceutical composition is suitable for clinical application. A new scheme is provided for the treatment of the disease.

The present invention relates to a dandelion active component extraction process optimization method based on an I-WO-SVR model. The method comprises: acquiring factors to be predicted, wherein said factors comprise the ethanol concentration, ultrasonic time, ultrasonic temperature and ultrasonic power; and inputting said factors into an I-WO-SVR model, so as to acquire the extraction rate of chlorogenic acid from dandelion flowers and stems, wherein the I-WO-SVR model is obtained by using a training set to train a support vector regression (SVR) prediction model and using an improved walrus optimizer (I-WO) to optimize a penalty parameter and a nuclear parameter of the SVR prediction model, and the training set comprises original factors and chlorogenic acid extraction rates corresponding to the original factors. The present invention combines modern artificial intelligence technology with the field of traditional Chinese medicine to design a Chinese medicinal material active component extraction optimization method, has broad application prospects, and can provide new ideas for Chinese medicine extraction and intelligent industrial production thereof.

The invention discloses a fat-reducing composition as well as a preparation method and application thereof. The fat-reducing composition comprises a hippophae rhamnoides leaf extract and a first mixed component and / or a second mixed component, wherein the first mixed component comprises an ampelopsis grossedentata extract and a fructus momordicae extract, the second mixed component comprises first coffee freeze-dried powder and second coffee freeze-dried powder, and the second coffee freeze-dried powder contains chlorogenic acid. The preparation method of the fat-reducing composition comprises the step of mixing all the components. All the components of the fat-reducing composition provided by the invention have a better fat-reducing effect through synergistic interaction, all the components belong to safe and side-effect-free components, dependence is not generated, and fat can be reduced more effectively.

The invention belongs to the technical field of biomedical materials, and discloses a preparation method of nano composite hydrogel and application of the nano composite hydrogel in acceleration of healing of diabetic wounds. The invention constructs the hydrogel based on the epsilon-polylysine grafted by the oxidized hyaluronic acid and the phenylboronic acid and the ZIF-8. Due to the existence of the dynamic Schiff base, the boric acid ester bond and the coordination bond, the hydrogel has ideal mechanical property, strong viscosity, injectability, self-healing property and pH / ROS responsiveness. Due to the existence of chlorogenic acid and zinc ions, the hydrogel regulates macrophage phenotypes, relieves oxidative stress and accelerates healing of diabetic wounds through an NF-kappa B / JAK-STAT signal channel.

The invention provides a preparation method of an artemisia capillaris decoction reference sample. The invention also provides a construction method of the high performance liquid characteristic chromatogram of the artemisia capillaris decoction reference sample. According to the invention, the characteristic chromatogram of the artemisia capillaris decoction is constructed by adopting the high performance liquid chromatography for the first time, the blank of quality control of the artemisia capillaris decoction is filled through the method of the characteristic chromatogram, meanwhile, the quality condition of the prescription is comprehensively reflected, the quality control of the artemisia capillaris decoction is more perfect, and a means is added for the quality standard aspect of the artemisia capillaris decoction. According to the method disclosed by the invention, gradient elution is adopted for determination by adopting a high-performance liquid chromatography, and the method has the advantages of simplicity in operation, good separation degree, high precision, good repeatability, good stability and the like. Under specific detection conditions, the identification of the artemisia capillaris decoction characteristic spectrum method can be realized by taking a chlorogenic acid chromatographic peak as a reference substance S peak.

Provided is a use of chlorogenic acid and a chlorogenic acid-rich substance in control of citrus huanglongbing (HLB); where a bacteriostatic agent includes the chlorogenic acid, and the chlorogenic acid has an effective concentration of greater than or equal to 0.5 mg / mL. In the present disclosure, an antibacterial test of the chlorogenic acid on Candidatus Liberibacter asiaticus (CLas) has confirmed that the chlorogenic acid shows a significant inhibitory effect on the CLas. It is also proven in the field that application of the chlorogenic acid exhibits an obvious therapeutic effect on diseased trees to be treated, indicating application prospects of the chlorogenic acid in controlling the citrus HLB. Moreover, the chlorogenic acid, as a green, natural, and non-toxic bioactive substance, is widely used in medical, food, and health care industries, with convenient sources, controllable costs, and strong feasibility.

The invention provides a liver-protecting probiotic composition and application thereof in prevention or treatment of acute liver injury, and belongs to the technical field of microorganisms and medicines. The invention provides lactobacillus crispatus LJ003, and the preservation number of the lactobacillus crispatus LJ003 is CGMCC (China General Microbiological Culture Collection Center) No.30723. The invention further provides a method for preparing fermented globe artichoke leaf powder, polyphenol and chlorogenic acid by using the lactobacillus crispatus LJ003, and the fermented globe artichoke leaf powder prepared by using the lactobacillus crispatus LJ003. The prepared fermented globe artichoke leaf powder can be used for preparing the liver protection probiotic composition, and the obtained liver protection probiotic composition has a good protection effect on liver cells, can effectively improve liver cell lipid metabolism disorder caused by excessive ethanol intake, and has a remarkable effect on preventing or treating acute liver injury.

The invention relates to the technical field of daily chemical and skin external preparations, in particular to a six-dimensional synergistic effect-based acne removal and repair composition, which is prepared from the following active ingredients in parts by weight: 1 to 10 parts of sturgeon caviar extract, 0.1 to 10 parts of chlorogenic acid, 0.1 to 20 parts of 4-tert-butyl cyclohexanol and 0.1 to 20 parts of willow extract. The sturgeon caviar extract is prepared by supercritical CO2 fluid extraction, the willow extract is treated by a synthase process, the content of salicin is not less than 1.5 wt%, and at least one active component in the composition is subjected to supramolecular inclusion modification; the preparation method comprises the following steps: sequentially preparing the extracts and components, sequentially mixing, and finally carrying out an inclusion reaction. The composition constructs a full-link acne removal and skin health maintenance system through a six-dimensional synergistic effect of bacteriostasis, oil control, anti-inflammation, allergy relief, cutin dredging and repairing, has the characteristics of efficient acne removal, mildness, safety and low recurrence rate, is suitable for various skin types such as sensitive acne skin, and can be widely applied to acne removal products of various dosage forms.

The invention discloses an anti-hair loss and hair growth essence and a preparation method thereof, the anti-hair loss and hair growth essence comprises a solid component A and a liquid component B, the component A comprises a lipid exosome hybrid vesicle freeze-dried powder, and the lipid exosome hybrid vesicle freeze-dried powder comprises lipid exosome hybrid vesicles and a freeze-drying protective agent; the lipidosome and exosome hybrid vesicle is obtained by fusing lipidosome and exosome through a membrane; the freeze-drying protective agent comprises zinc ions, chlorogenic acid and trehalose. The essence has good room-temperature storage stability and transdermal permeability, improves the cell utilization rate of active substances, and has a good prevention and treatment effect on AGA.