25 results about "Oleanolic acid" patented technology

The invention provides a novel application of a raspberry extract. It is found through tests that any one of isoquercitrin, ellagic acid, vanillic acid, oleanolic acid, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, tiliroside, tormentic acid and raspberry extract can remarkably improve the activity of the human ovarian granular cells or remarkably improve the oxidative stress level, and the activity of the human ovarian granular cells can be remarkably improved. According to the present invention, the ovarian function can be effectively protected by the eight components, the ovarian function can be effectively protected by the eight components, or the mitochondrial membrane potential level can be significantly regulated and controlled, or the estrogen level in the microenvironment can be effectively maintained, such that the ovarian function can be effectively protected by the eight components, and the raspberry extract containing the eight components. The invention provides a new choice for ovarian function protection products, and also provides a new application for the substances.

To provide wound-healing formulations containing solid birch bark extracts that may be applied to the skin without worsening the patient's condition.SOLUTION: A solid birch bark extract comprises at least about 70 wt.% of betulin, and one or more triterpenes selected from the group consisting of betulinic acid, oleanolic acid, erythrodiol, and lupeol.SELECTED DRAWING: None

Disclosed herein are oral care compositions, and preferably, oral care compositions providing reduced gingival bleeding, as well as methods for producing such oral care compositions. According to some aspects, there is provided a substrate having a stannous source; a nitrate source; a source of phosphate radicals; a surfactant system, the surfactant system comprising a sulfate based anionic surfactant; oleanolic acid; and eugenol, and an oral care composition.

The invention belongs to the technical field of medicines, and particularly relates to an experimental method for treating liver cancer by using oleanolic acid. Comprising an in-vitro experiment method and an in-vivo experiment method. The in-vitro experiment method comprises the following steps: S1, cell culture; s2, cell proliferation and migration; s3, detecting cell apoptosis and a cell cycle; s4, performing immunoblotting; s5, carrying out real-time quantitative PCR; the in-vivo experiment method comprises the following steps: step 1, performing chick embryo chorioallantoic model experiment; and 2, carrying out tumor-bearing experiment, treatment and tissue sampling on the mouse. The application of the oleanolic acid in liver cancer treatment is systematically researched for the first time, it is found that the oleanolic acid has the remarkable effects of inhibiting proliferation, inducing apoptosis, resisting angiogenesis and the like on liver tumors through the synergistic effect of multiple mechanisms, the remarkable curative effect on cancer mice is achieved, and a new medicine choice is provided for liver cancer treatment.

The application belongs to the field of new adjuvants and new dosage forms of pharmaceutical preparations, and particularly relates to a type I and type II immunogenic cell death inducer ion pairing engineered nanoassemblies as well as construction and application thereof. The nanoassemblies are composed of type I ICD inducers, type II ICD inducers, hydrophobic auxiliary counterions and amphiphilic lipid ion pairing. The type I ICD inducer is selected from mitoxantrone, doxorubicin, oxaliplatin or cyclophosphamide; the type II ICD inducer is selected from hypericin; and the hydrophobic auxiliary counterion is selected from cholesteryl sodium sulfate, cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid, glycolcholic acid, taurocholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, deoxycholic acid lysine derivative, oleanolic acid and ursolic acid. The type I and type II ICD inducers are combined in the application, and have a synergistic tumor treatment effect.

The invention relates to the technical field of liqueur, in particular to liqueur and a preparation method thereof.The liqueur is prepared by soaking various medicinal and edible raw materials such as kudzuvine roots, rice, barbary wolfberry fruits, smoked plums, grapes, mulberries, poria cocos, Chinese yams, rhizoma polygonati, jujubes and ginseng in baijiu base liquor according to a specific proportion. According to the present invention, the modern analysis technology shows that the wine contains 25 active components such as resveratrol, protocatechuic acid, oleanolic acid, quercetin, kaempferol and the like, and the components achieve the synergistic effect, such that the product has effects of tumor resistance, liver protection, blood sugar reduction, blood fat reduction, oxidation resistance, inflammation resistance, nerve protection and other health-care functions, and the product has characteristics of definite component, synergistic effect, high safety, and no toxic-side effect. The preparation process is stable and controllable, and is suitable for large-scale production.

The invention belongs to the field of plant genetic engineering, and particularly relates to an entada phaseoloides EpCYP88 gene and application of the entada phaseoloides EpCYP88 gene to production of entada phaseoloides acid by catalyzing oleanolic The invention discloses a key gene EpCYP88 in biosynthesis of entada phaseoloides specific metabolite entada phaseoloides acid. The nucleotide sequence of the gene is shown as SEQ ID NO.1; the amino acid sequence of the EpCYP88 protein coded by the gene is as shown in SEQ ID NO. 2; the protein is used as a key enzyme for catalyzing the dihydroxylation of oleanolic acid to realize the heterologous production of entada phaseoloides acid in a model plant (tobacco). Conditions are created for mass production of entada phaseoloides acid in tobacco, and the cost of obtaining entada phaseoloides acid is greatly reduced.

The invention provides a chlorhematin-containing plant growth regulator as well as a preparation method and application thereof, and relates to the technical field of plant growth regulators. The plant growth regulator containing chlorhematin is prepared from the following raw materials in percentage by mass: 0.2 to 0.5 percent of microencapsulated chlorhematin, 3 to 6 percent of triterpenoid saponin, 1 to 2 percent of oleanolic acid-beta-cyclodextrin inclusion compound, 3 to 6 percent of tea saponin, 2 to 4 percent of sodium lignin sulfonate, 0.2 to 0.5 percent of polyether modified organic silicon defoaming agent, 1 to 3 percent of sodium polyacrylate dispersing agent, 0.5 to 1.5 percent of polyvinyl alcohol and the balance of water. 0.5-1.5% of sodium carboxymethyl cellulose and the balance of pre-gelatinized starch; the microencapsulated hemin wall material consists of sodium alginate, chitosan and gelatin in a mass ratio of 3: (2-3): 1; the triterpenoid saponin is gynostemma pentaphyllum saponin and / or ginsenoside.

The application discloses a detection method and application of ursolic acid and total triterpenes in prunella vulgaris seed and prunella vulgaris seed oil. The detection method is characterized in that ursolic acid in prunella vulgaris seed and prunella vulgaris seed oil is qualitatively identified by using a thin layer chromatography method; oil and fat components interfering with determination of total triterpenes are separated and removed by column separation, and then the content of total triterpenes in prunella vulgaris seed and prunella vulgaris seed oil is determined by using spectrophotometry with ursolic acid or oleanolic acid as a control, so that the problems of interference and false high content in determination of the content of total triterpenes in oil components in the prior art are overcome. The method has the advantages of high accuracy and precision, good stability and repeatability, and provides a method for quality detection of triterpenes in development and utilization of prunella vulgaris seed and prunella vulgaris seed oil, and has strong specificity and good reproducibility.

The application discloses a thin-layer identification method of Belamcanda chinensis in gynecological itching-relieving tablets and relates to the technical field of traditional Chinese medicine quality control. The thin-layer identification method is characterized in that ursolic acid and oleanolic acid are used as the control samples, the developing agent is composed of ethyl ether and dichloromethane in a volume ratio of 0-2:6-9, and the color developing agent is 10% sulfuric acid ethanol solution.

The invention relates to a composition for oral or topical human administration and a preparation method thereof. The present invention relates to pentacyclic triterpenoid compounds wherein said triterpenoid compounds are incorporated into lipid vesicles, preferably cream globules, surrounded by three layers of membranes. The triterpenoid is preferably betulinic acid, and / or betulinol, and / or lupenol, and / or oleanolic acid, and / or ursolic acid, most preferably betulinic acid. The incorporation of the triterpenoid compound into the milk fat globules or lipid vesicles at a high payload of at least 10 to at most 50 mg / ml is preferably accomplished with high energy emulsification techniques, most preferably ultrasound treatment. The composition is present as a liquid emulsion formulation in a preferred embodiment. In another preferred embodiment, the composition is a powder, which can be prepared from a liquid embodiment of the composition by, for example, spray drying or freeze drying techniques. The composition can be preferably used as a medicament, a food supplement or a nutraceuticals for the treatment or prevention of cancer, type 2 diabetes, obesity and cardiovascular diseases.

An oleanane-type triterpenoid or a glycoside thereof is useful as a compound having an effect of inducing formation of cilium and activating hair papilla cells or hair matrix cells.

The present application relates to the field of cosmetics, especially to an anti-aging essence and a preparation device, which is composed of A phase, B phase, C phase and D phase, and the components of each phase are as follows according to weight percentage: A phase: deionized water 16.15%, rose hydrolat 18.00%, propylene glycol 5.00%, glycerol 4.00%, xanthan gum 0.15%, carbomer 940 0.10%, panthenol (vitamin B5) 2.00%, boswelia (30% aqueous solution) 10.00%, ikedoin 2.00%, nicotinamide 2.00%, sodium hyaluronate compound 0.50%; B phase: polyglyceryl-6 distearate 1.20%, squalane 3.00%, isononyl isononanoate 2.00%, octyldodecanol 5.00%, rosehip oil 0.50%, argan oil 0.50%, ceramide compound powder 0.50%, cholesterol 0.30%, free fatty acid (C18-C22) 0.20%, Transcutol P 4.00%, oleanolic acid (ligustrum lucidum extract) 0.50%, plant extract compound liquid 5.00%, ergothioneine 0.30%. The advantages are that the active ingredient utilization rate is improved, the efficacy is comprehensive and the synergistic effect is strong, and the preparation device can make the mixing of each component more uniform, greatly improving the mixing efficiency.

This invention provides a CYP716 gene, protein, and applications for catalyzing the oxidation of β-amyrin at the C22α and C28 positions, belonging to the field of biotechnology. The CYP716 gene includes either CYP716BX1 (nucleotide sequence as shown in SEQ ID No. 1) or CYP716BX2 (nucleotide sequence as shown in SEQ ID No. 2). Studies have shown that CYP716BX1 and CYP716BX2 are isoenzymes, both capable of catalyzing the oxidation of β-amyrin at the C22α and C28 positions to 22α-hydroxy-kapogonadiol or 22α-hydroxy-oleanolic acid, and also capable of catalyzing the oxidation of 21β-hydroxy-β-amyrin at the C22α and C28 positions to 21β,22α-dihydroxy-kapogonadiol. This invention can provide key gene elements for the synthetic biology research of cyrimyl alcohol-type triterpenoids.

The invention discloses a dogwood flower extract with anti-oxidation and blood sugar and lipid reducing effects as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention aims to solve the technical problems of regulating blood sugar, insulin, blood fat and antioxidant level by activating a PI3K / AKT / mTOR pathway in vivo, improving liver, kidney and pancreas injuries and exerting anti-diabetic activity by reducing inflammatory factor expression. According to the key point of the technical scheme, the invention discloses a dogwood flower extract with the effects of resisting oxidation and reducing blood sugar and blood lipid. The active ingredients of the dogwood flower extract comprise morroniside, swertioside, loganin, ursolic acid, oleanolic acid, dogwood neoglycoside, gallic acid, protocatechuic acid, p-hydroxybenzoic acid, catechin, chlorogenic acid, caffeic acid, epicatechin, orientin, rutin, ferulic acid, benzoic acid, resveratrol, quercetin and cinnamic acid.

The invention provides a conyza blinii extract (tablet) fingerprint spectrum detection method, which comprises: A) taking a test sample raw material, and pre-treating to obtain a liquid to be detected; the pretreatment mode comprises solvent dissolution and extraction; b) measuring the liquid to be measured by adopting a high performance liquid chromatography-evaporative light scattering method to obtain an HPLC-ELSD (High Performance Liquid Chromatography-Evaporative Light Scattering Detector) fingerprint spectrum of the Conyza blinii extract (tablet); chromatographic conditions of the high performance liquid chromatography are as follows: a chromatographic column is a C18 column; a mobile phase A is an acetonitrile solution, a mobile phase B is a 0.1% formic acid aqueous solution, and gradient elution is carried out; according to the method, a high performance liquid chromatography-evaporative light scattering method is adopted, an acetonitrile-0. 1% formic acid aqueous solution is selected as a mobile phase for gradient elution, ursolic acid, oleanolic acid, beta-amyrin, alpha-amyrin and friedelin are taken as reference substances, and the conyza blinii extract (tablet) fingerprint detection method is established. The scientificity and the internal quality of the conyza blinii extract (tablet) are integrally evaluated.

The invention relates to the technical field of functional food, in particular to a composition with the effects of reducing blood sugar and regulating blood fat and application of the composition. The invention provides a composition with the effects of reducing blood sugar and regulating blood fat, the composition comprises a cyclocarya paliurus triterpenoic acid compound and a selenoprotein additive, and the effect is optimal when the mass ratio of ursolic acid to oleanolic acid to betulinic acid to arjiurolic acid in the cyclocarya paliurus triterpenoic acid compound is optimized to be 1: 3.21: 3.37: 0.74 through a response surface experiment. According to the invention, the cyclocarya paliurus triterpene component and the selenium food nutrition enhancer are used at the same time, so that the cyclocarya paliurus selenium food nutrition enhancer can reduce blood sugar, regulate blood fat and increase the antioxidant capacity of the body, also has the functions of inhibiting postprandial blood sugar rise, relieving insulin resistance and protecting liver islet, and can meet the selenium intake of 50-200 micrograms per day of adults recommended by Chinese Nutrition Association; the health-care food can be used as a novel functional food to be applied to prevention and health care of sub-health people with hyperglycemia and hyperlipidemia.

The invention provides a novel application of a raspberry extract. It is found through tests that any one of isoquercitrin, ellagic acid, vanillic acid, oleanolic acid, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, tiliroside, tormentic acid and raspberry extract can remarkably improve the activity of the human ovarian granular cells or remarkably improve the oxidative stress level, and the activity of the human ovarian granular cells can be remarkably improved. According to the present invention, the ovarian function can be effectively protected by the eight components, the ovarian function can be effectively protected by the eight components, or the mitochondrial membrane potential level can be significantly regulated and controlled, or the estrogen level in the microenvironment can be effectively maintained, such that the ovarian function can be effectively protected by the eight components, and the raspberry extract containing the eight components. The invention provides a new choice for ovarian function protection products, and also provides a new application for the substances.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine white panax notoginseng steaming processing quality control method, which comprises the following steps: mixing ginsenoside Ro, pseudoginsenoside RT1, panax japonicus saponin IV, panax japonicus saponin IVa, gingerous notoginsenoside R1, pseudo-ginsenoside RP1, calendula officinalis glycoside E, oleanolic acid beta-D-glucopyranose ester, ginsenoside RK1 and ethanol, stirring, filtering, and drying to obtain a finished product. Obtaining a reference substance solution; grinding and sieving the steamed white pseudo-ginseng powder, adding the powder into ethanol or methanol, uniformly stirring, performing ultrasonic extraction, fixing the volume, centrifuging and collecting supernate to obtain a test solution; the reference solution and the test solution are injected into a high performance liquid chromatograph for content detection, the retention time RSD of the nine components is smaller than 0.85%, the peak area RSD of the nine components is smaller than 2.44%, and therefore the detection and analysis method has good precision.

The invention provides application of combination of hedyotis diffusa and curcuma zedoary in preparation of anti-colon cancer drugs, and belongs to the technical field of medicines.The application is characterized in that anti-colon cancer active components in hedyotis diffusa and curcuma zedoary are screened through network pharmacology and molecular docking research; the active ingredients of quercetin, oleanolic acid, beta-sitosterol and bis (demethoxycurcumin) in the two medicines can synergistically inhibit tumor cell proliferation, promote apoptosis and intervene tumor progression. The invention further provides a preparation method of the oldenlandia diffusa and curcuma zedoary extract for preparing the anti-colon cancer medicine. The extract has a good inhibition effect on cell proliferation of HCT116 and HT-29 colon cancer cells.

A COMPOSITION FOR TREATING KERATIN MATERIAL AND METHODS THEREOF The present disclosure provides a composition (A) comprising: a. oleanolic acid, its salts, solvates, or their mixtures thereof; b. ursolic acid, its salts, solvates, or their mixtures thereof; c. betulinic acid, its salts, solvates, or their mixtures thereof; and d. micromeric acid, its salts, solvates, or their mixtures thereof. The present disclosure further provides a rosemary extract and a composition (B). The present disclosure also provides a process for preparing the composition (A), the extract and methods thereof.

The invention provides a novel application of a raspberry extract. It is found through tests that any one of isoquercitrin, ellagic acid, vanillic acid, oleanolic acid, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, tiliroside, tormentic acid and raspberry extract can remarkably improve the activity of the human ovarian granular cells or remarkably improve the oxidative stress level, and the activity of the human ovarian granular cells can be remarkably improved. According to the present invention, the ovarian function can be effectively protected by the eight components, the ovarian function can be effectively protected by the eight components, or the mitochondrial membrane potential level can be significantly regulated and controlled, or the estrogen level in the microenvironment can be effectively maintained, such that the ovarian function can be effectively protected by the eight components, and the raspberry extract containing the eight components. The invention provides a new choice for ovarian function protection products, and also provides a new application for the substances.

The invention belongs to the technical field of traditional Chinese medicine detection, and particularly relates to a method for determining the contents of multiple components in oldenlandia diffusa, which adopts a high performance liquid chromatography to determine the contents of quercetin, oleanolic acid and ursolic acid in the oldenlandia diffusa. The multi-component content determination method established by the invention has the advantages of good linear range, high specificity, high accuracy, high precision, high repeatability, stability and feasibility, and can be applied to quality detection of oldenlandia diffusa.

The present disclosure addresses the problem of providing a novel autophagy inducer.　The present disclosure pertains to an autophagy inducer containing a triterpene compound, and the like. In particular, the autophagy-inducing action of cells is effectively promoted by containing an oleanane-type triterpene having a five-ring structure, oleanolic acid, an olive leaf extract, a Ligustrum lucidum extract, and the like. Said autophagy inducer can be formulated as a solid composition, a food and drink composition, a cosmetic, or a medicine, and an excipient can also be used in combination.