632 results about "Oleanolic acid" patented technology

The present invention includes 1) a novel formulation for the treatment of hair loss comprising oleanolic acid (a 5α-reductase inhibitor), apigenin (a vasodilator), and biotinyl-GHK (a cell metabolism stimulant), 2) a novel additive for the treatment of hair loss comprising oleanolic acid, apigenin, biotinyl-GHK and a delivery agent, 3) a personal care, cosmetic, and/or dermopharmaceutical composition comprising oleanolic acid, apigenin, biotinyl-GHK, and at least one additional ingredient, and 4) a method for treating hair loss comprising the administration of oleanolic acid, apigenin, and biotinyl-GHK.

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:

wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.

The invention discloses a slowly-released compound acidifier for poultry and livestock feed, a preparation method thereof and feed containing the same. The compound acidifier comprises the following compositions in part by weight: 30 to 80 parts of complex organic acid, 15 to 50 parts of supplementary materials and 5 to 20 parts of coating agents. The complex organic acid is citric acid, fumaric acid, malic acid, lactic acid, linoleic acid, crataegolic acid, ursolic acid, chlorogenic acid, glycyrrhizic acid and oleanolic acid, and the supplementary materials are silicon dioxide, hydroxypropyl methylcellulose and ethyl cellulose. The acidifier is scientifically proportioned, has strong efficiency and is long-acting and slow-releasing, nutrients in the feed are free from being damaged, the acidifier has good fluidity and is easy to be uniformly mixed with the feed, the digestive absorption of nutrients can be promoted, the conversion rate of the feed can be improved, the productivity of poultry and livestock can be improved, the time for domestic animals for sale can be effectively shortened, the health of gastrointestinal mucosa of the animals can be protected, the immunologic function of the animals can be strengthened, and diseases can be prevented.

A method of treating non-insulin dependent diabetes mellitus comprising the step of providing a composition comprising a predetermined amount of berberine and a predetermined amount of catalpol, wherein said berberine and said catalpol are major active ingredients of said composition. The composition may further comprise a predetermined amount of oleanolic acid as another active ingredient. The berberine is obtained from natural herbs selected from the group of Berberis, Chelidonium, Stephniz, Coptis, Phellodendron, and Ziziphus, the catalpol is obtained from natural herbs selected from the group of Rehmannia, Verbascum, Panulownia, Glubularia and Adonis, and the oleanolic acid is obtained from natural herbs selected from the group of Olea, Swertia, Astrantia, Lonicera and Beta.

An anti-aging composition is provided that contains high potency retinol along with anti-irritant properties. In particular, an anti-aging composition includes a base, from about 0.001% to 20.0 vol % retinol, at least one anti-irritant agent, at least one antioxidant, at least one anti-inflammatory agent, and a moisturizing complex. In one non-limiting illustration, the anti-aging composition contains about 1.0 vol % retinol, plantago lanceolata, hypericum perforatum leaf extract, phytosphingosine, leontopodium alpinum extract, glycyrriza glabra root extract, sambucus nigra flower extract, nordihydrognaiaretic acid, oleanolic acid, spiraea ulmaria flower extract, evodia rutaecarpa fruit extract, boswellia serrata extract, and additives.

The invention relates to novel oleanolic acid derivatives, and a preparation method and an application thereof. The compounds are modification compounds of 3-site and 28-site substitutes in an oleanolic acid structural formula, are prepared with oleanolic acid as a raw material and by a chemical synthesis method, and can be used for treatment of cancer, diabetes, AIDS, hepatitis B and hepatitis C.

The invention discloses total triterpene extract and total phenol extract extracted from Chinese herbal medicine glossy privet fruit and a preparation method thereof. The total triterpene extract mainly contains oleanolic acid, ursolic acid, acetyl oleanolic acid, indicant compound and other derivatives with acetyl oleanolic acid as the mother nucleus. The total phenol extract mainly contains hydroxyl mandelic, 3, 4-dihydroxy phenylethyl alcohol, salidroside and indicant compound and other derivatives with salidroside as the mother nucleus. The glossy privet fruit total triterpene extract and total phenol extract can be prepared by any method of solvent distillation, solvent extraction, deposition, macroporous resin absorption, supercritical fluid extraction, column chromatography and liquid-liquid countercurrent distribution chromatography, or any combination of these methods. The total percentage of various triterpenoids of the prepared glossy privet fruit total triterpene extract is 5 to 100 percent (w/w); wherein, the content of oleanolic acid and ursolic acid accounts for 5 to 100 percent (w/w) of the total triterpene. The total percentage of various phenols of the prepared glossy privet fruit total phenol extract is 5 to 100 percent (w/w); wherein, the content of salidroside accounts for 5 to 100 percent (w/w) of the total phenol.

A UGT2B inhibitor capable of increasing the bio-availability of a drug, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: capillarisin, isorhamnetin, β-naphthoflavone, α-naphthoflavone, hesperetin, terpineol, (+)-limonene, β-myrcene, swertiamarin, eriodictyol, cineole, apigenin, baicalin, ursolic acid, isovitexin, lauryl alcohol, puerarin, trans-cinnamaldehyde, 3-phenylpropyl acetate, isoliquritigenin, paeoniflorin, gallic acid, genistein, glycyrrhizin, protocatechuic acid, ethyl myristate, umbelliferone, PEG (Polyethylene glycol) 400, PEG 2000, PEG 4000, Tween 20, Tween 60, Tween 80, BRIJ® 58, BRIJ® 76, Pluronic® F68, Pluronic® F127, and a combination thereof. A UGT2B enhancer capable of enhancing a clearance rate of morphine-like analgesic agents, is a compound in a free base or a pharmaceutically acceptable salt form that is selected from the group consisting of: nordihydroguaiaretic acid, wogonin, trans-cinnamic acid, baicalein, quercetin, daidzein, oleanolic acid, homoorientin, hesperetin, narigin, neohesperidin, (+)-epicatechin, hesperidin, liquiritin, eriodictyol, formononetin, quercitrin, genkwanin, kaempferol, isoquercitrin, (+)-catechin, naringenin, daidzin, (−)-epicatechin, luteolin-7-glucoside, ergosterol, rutin, luteolin, ethyl myristate, apigenin, 3-phenylpropyl acetate, umbelliferone, glycyrrhizin, protocatechuic acid, poncirin, isovitexin, 6-gingerol, cineole, genistein, trans-cinnamaldehyde, and a combination thereof.

The invention provides an oleanolic acid triterpenoid, whose A ring and C ring contain multiple oxygen substituents, represented as formula (1). The inventive compound can inhibit the growth activity of tumor cell, thereby being applied in the preparation of anti-tumor drug and can inhibit mice ear swelling caused by dimethylbenzene, thereby being applied in the preparation of anti-inflammatory agent. The formula (1) is represented as above.

The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of conditions related to pain and inflammation and/or as ingredients of dietary supplements. The invention also relates to optimization of the methods for qualitative and quantitative analysis of the bioactive compounds in oregano and mint plants. In particular, this invention introduces an LC/MS (SIM mode) method to achieve co-quantitation of the three organic acids using a unique tandem column system. In addition, the invention also relates to the methods for recovering various water-soluble polyphenols and triterpenes from aromatic plants.

A composition and a method for using the composition to delay the onset of the symptoms of Alzheimer's disease in humans, comprising curcumin, piperine, oleic acid, oleanolic acid, ursolic acid, galantamine, and huperzine A, among other compounds. Curcumin is an antioxidant, while galantamine and huperzine A inhibit the activity of acetylcholinesterase in the brain. Piperine and oleic acid increase the bioavailability and gastrointestinal absorption of curcumin, galantamine, huperzine A, and other nutrients.

The invention discloses an extracting method of urson and oleanolic acid from bitter leaves, which comprises the following steps: adopting bitter leaves from Hainan as raw material; extracting through pure water; filtering; refluxing filter slag to extract through alcohol; adopting inorganic film filtering method to remove macromolecular impurity in the extract; hyperfiltering; condensing the penetration liquid through nanofiltering; adsorbing and eluting through macromolecular resin chromatographic column; condensing eluent to crystallize; obtaining rough product of total triterpenic acid; washing the rough product; dissolving in the alcohol; alkalining; acidifying; washing again; recrystallizing; obtaining the total triterpenic acid; dissolving the total triterpenic acid in the carbinol to boil; filtering; condensing filtrate; evolving; obtaining the monomer product of oleanolic acid; washing the sediment; dissolving the crystal through alcohol; obtaining the monomer product of urson; hyperfiltering and clarifying filtrate of bitter leaves; nanofiltering; condensing; adsorbing through polyamide resin selectively; eluting; condensing the eluent; obtaining the monomer of tea polyphenol with certain purity.

Improved methods and compositions for protecting plants or seeds from plant diseases are provided. The compositions comprise (and preferably consist essentially of) saponin, such as triterpene type saponins extracted from quinoa or quillaja. Compositions according to the invention may comprise (or consist essentially of) a quantity of a sapogenin compound, preferably a sapogenins selected from the group consisting of oleanolic acid, hederagenin, phytolaccinic acid, and quillaic acid. The methods comprise contacting the portion of the plant (e.g., foliage, shoot, etc.) to be treated with a disease-inhibiting or protective amount of the composition. The compositions can also be used to treat plant seeds or tubers prior to planting thereof, as well as soil adjacent a growing plant. The inventive compositions are particularly useful for the treatment, control and/or prevention of bacterial diseases. The saponins of the invention can be applied as liquids or dry particulates, and are especially suited for the treatment of tomato and potato plants and their respective seeds.

The invention relates to the liposome with oleanolic acid, relative freeze dried. Wherein, the liposome comprises oleanolic acid, phosphatide, cholesterol and surface activator, while their ratios are 1:10-80:0-20:0-50; the freeze dried is formed by oleanolic acid agent, dextran, monosaccharide, diose and/or polysaccharide, while their amounts are based on the mass of phosphatide, that one deal of phosphatide takes 0.2-5.0 deals of them; when the oleanolic acid is made into liposome, it can be inactively targeted into liver, to improve the drug density and reduce side effect; the drug will be slowly released in human body, to prolong the effective time; and its package rate is higher than 75%, particle diameter is 100-800cm.

The present invention relates to a composition containing peptide of SEQ ID No. 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.

The invention discloses pentacyclic triterpenoid cyclodextrin clathrate compound proliposome and a preparation method thereof. The main component comprises one or more of pentacyclic triterpenoid compound series, for example, ursolic acid, oleanolic acid, betulonic acid, beta-masticinic acid, cyclodextrin clathrate compound, phospholipid material and cholesterol. According to the pentacyclic triterpenoid cyclodextrin clathrate compound proliposome, the pentacyclic triterpenoid compound is clathrated through cyclodextrin to improve the hydrophilicity; the liposome is used as a carrier to clad, and the proliposome is obtained by freezing and drying. According to the pentacyclic triterpenoid cyclodextrin clathrate compound proliposome, the bioavailability and the stability of the pentacyclic triterpenoid compound can be improved; transdermal absorption is promoted, and the skin irritation is reduced. In addition, the cyclodextrin clathrate compound proliposome is of a powder shape, good in stability and rehydration reconstruction and convenient to use, and can be applied to a plurality of cosmetic dosage forms such as cream, emulsion, gel and essence.

The invention discloses a recombinant saccharymyces cerevisiae for producing ginsengenins as well as a construction method and an application of the same. The recombinant saccharymyces cerevisiae capable of producing three ginsengenins of oleanolic acid, protopanoxadiol and protopanaxatriol simultaneously is Saccharymyces cerevisiae GY-1, with a collection number of CGMCC No. 7725 in the China General Microbiological Culture Collection Centre. The saccharymyces cerevisiae GY-1 is capable of producing three ginsengenins of oleanolic acid, protopanoxadiol and protopanaxatriol simultaneously, wherein the yields achieve 21.4 mg/L in fermentation broth, 17.2 mg/L in fermentation broth and 15.9 mg/L in fermentation broth respectively, the proportions of which in the total ginsengenin content are 39.3%, 31.5% and 29.2% respectively.

The invention relates to the field of medicines, concretely relates to an oleanolic acid derivative represented by formula I and pharmaceutically acceptable salts, and a preparation method and a medicinal use thereof, and belongs to the field of biomedicines. The preparation method of the above compounds has the advantages of mild condition, simple operation, high yield and very strong practicality. Results of pharmacological experiments show that the compounds have excellent anti-inflammatory and antitumor activities, and can be clinically used as medicines for treating diseases and tumors caused by various inflammations.