900 results about "Gastric mucosa" patented technology

A pharmaceutical composition in the form of a combination tablet is described. The tablet has a rapidly absorbed component that enters the circulation by traversing the buccal mucosa, oral mucosa and combinations thereof, and a more slowly absorbed component that is swallowed. The therapeutic agent in the swallowed portion is absorbed across the gastric mucosa. The combination tablet may be modified, by varying the specific combinations of excipients, fillers, and the like to effect distinct release rates. In addition, the rapid and slow components may have identical or different therapeutic agents depending on the application to a specific medical condition. One embodiment of the combination tablet includes a prostaglandin inhibitor in the rapidly absorbed component in order to mitigate the side effects of immediate release niacin that is in the slow absorbing component. Such combination compositions will increase patient compliance with various dosing regimens due to the resultant decrease in the number of tablets that a patient would need to take on a daily basis.

Bioadhesive macrosphere delivery systems (“BDDS”) having prolonged gastric retention time due to bioadhesion rather than physical density or size are described. In general, the macrospheres have diameters that are greater than 200 microns, more preferably greater than 500 microns. The bioadhesive macrospheres are released in the stomach where they reside in close proximity to the gastric mucosa for a prolonged period of time. Increased residence of BDDS in the upper GI can lead to increased systemic absorption of drug in the preferred site of systemic absorption, namely the upper GI tract (upper to mid-jejunum). The BDDS may be engineered either as a capsule with drug delivery controlled by a diffusion-limited membrane or degradable shell, or as a solid matrix system with drug delivery controlled by a combination of diffusion and polymer degradation kinetics.

The present invention relates to one kind of Chinese medicine preparation for curing gastropathy radically. The Chinese medicine preparation is prepared with 29 kinds of Chinese medicinal materials, including astragalus root, corydalis tuber, cuttlebone, chicken's gizzard membrane, white atractylodes rhizome, etc. It has obvious curative effect on various kinds of chronic gastritis, antrum gastritis, digestive track ulcer, etc and no toxic side effect, and can prevent gastric cancer and gastric mucosa pathology.

Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and / or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. In some embodiments, the Helicobacter provides exposure of a desired molecule of interest though the surface of the Helicobacter, providing exposure of the antigen to the host at the gastric mucosa. Live Helicobacter pylori vaccines are also provided. Vectors and shuttle vector constructs of the Helicobacter are also disclosed.

The invention pertains to the field of medical technology and provides triterpenoid saponin in camellia seeds, and a preparation method and medical application thereof. The triterpenoid saponin is shown in a general formula (1), wherein, R1 is hydrogen or oxhydryl or acyloxy; R2 is the hydrogen or the acyloxy; R3 is the hydrogen or the acyloxy; R4 is the hydrogen or the acyloxy; R5 is methyl or methylol or aldehyde group or carboxyl or metheyl carboxyl; R6 is the hydrogen or orglycosyl; the preparation method comprises the following steps: macroporous resins are degreased, extracted by ethanol, decocted in water, desugared and decolored to obtain crude total saponins and then go though an opened ODS chromatographic column and repeated HPLC method to obtain the total saponins of camellia seeds and monomer theasaponin. The triterpenoid saponin compounds in the camellia seeds have the functions of protecting gastric mucosa, being antineoplastic, reducing blood sugar and blood fat and thelike and are used for preparing medicaments or health-care foods having the functions of protecting gastric mucosa, being antineoplastic and reducing blood sugar and blood fat.

The invention discloses medicinal liquor for treating rheumatic arthritis and chronic infectious arthritis, which comprises the following raw materials in parts by weight: 33-38 parts of Chinese parsnip root, 8-13 parts of asarum, 28-33 parts of the root of bidentate achyranthes, 28-33 parts of ligusticum sinense oliver, 28-33 parts of notopterygium root, 28-33 parts of radix angelicae pubescentis, 23-28 parts of prepared monkshood, 28-33 parts of cassia twig, 28-33 parts of pawpaw, 28-33 parts of radix clematidis, 28-33 parts of cortex acanthopanacis, 28-33 parts of semen coicis, 28-33 parts of corydalis tuber, 28-33 parts of large-leaved gentian, 4-9 parts of long-noded pit viper, 28-33 parts of the root of fangji, 28-33 parts of rhizoma typhonii, 28-33 parts of ligusticum wallichii, 28-33 parts of zaocys dhumnade, and 7000-8000 parts of 50-60-degree white wine. The medicinal liquor disclosed by the invention has the advantages of being low in cost, high in curative rate and free from toxic and side effects; stimulation of the existing medicines on gastric mucosa is overcome; simultaneously, the medicinal liquor disclosed by the invention also has the functions of tonifying liver and kidney.

A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing fastidious organisms is described. Submucosal tissue used in accordance with the present invention supports the proliferation of cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.

The invention discloses an enzyme linked immunosorbent assay kit for combined diagnosis of the gastrosis or evaluation of gastric cancer risks and a preparation method thereof. The kit comprises a micropore plate coated with an antibody against a pepsin antigen I or an antibody against a pepsin antigen II, an enzyme labeled antibody, a color-developing agent, a stop solution and a concentrated cleaning solution, wherein the pepsin antigen I or the pepsin antigen II is a natural protein obtained from extraction of human gastric mucosa tissue. The kit disclosed by the invention adopts a mouse immunized with pepsinogen I and pepsinogen II which are separated from human gastric mucosa to prepare immunogen of a monoclonal antibody, the used standard sample also adopts the pepsin antigen I or the pepsin antigen II separated from the human gastric mucosa, thereby the defects caused by adopting different structures of animal pepsinogen and human pepsinogen are filled. The kit can be used for accurately diagnosing the gastrosis or early gastric cancer and has the advantages of high sensitivity, strong specificity, good accuracy and the like.

The invention belongs to the technical field of drink foods, and in particular relates to an aloe bird nest drink food and a preparation method thereof. The aloe bird nest drink food comprises the following raw materials e by weight percentage: 0.05 to 40 percent of aloe, 0.005 to 0.2 percent of bird nest (in terms of dry basis), 1 to 50 percent of edulcorant, 0 to 20 percent of fruit and vegetable juice, 0 to 0.5 percent of acid taste additive and acid taste regulator, 0 to 6 percent of gelata, and 40 to 85 percent of water. The aloe bird nest drink food integrates the efficacy characteristics of the aloe and the bird nest, not only has fresh and lubricous mouthfeel, but also has the health care functions of invigorating the spleen and moistening the lung, protecting gastric mucosa, resisting inflammation and sterilizing, strengthening the immune system, resisting radiation, hairdressing and the like.

The invention relates to the field of functional foods, in particular to a composition and an application thereof in preparing a health-care product for alleviating stomach discomfort. According to the composition and the application thereof disclosed by the invention, fermented soybean flour, probiotics and prebiotics are in intercoordination effects, so that acute diseases of stomach pains and heartburn can be quickly alleviated, besides, the effects of helicobacter pylori can also be restrained, gastric mucosa is protected, and the purposes of adjusting gastroenteric functions and maintaining gastroenteric health are achieved. Experiments prove that 15 minutes after patients eat the composition provided by the invention, the symptoms of the stomach pains, the heartburn, water brash, nausea and cardialgia are alleviated, and the symptoms of 95% of patients are alleviated within 15 days.

The invention discloses antialcoholic sour milk, which contains vine root powder, taurine and soy peptide, which are fermented together. The sour milk is prepared by the following steps: examining raw pure milk, purifying the milk, mixing, homogenizing, sterilizing, cooling, inoculating, stirring, filling, fermenting, cooling, detecting and obtaining a finished product. The mixing process comprises: dispersing the vine root powder, vitamin C, taurine and soy peptide in pure milk in an amount which is 8 to 10 times the total amount of the vine root powder, vitamin C, taurine and soy peptide, and uniformly mixing the materials by stirring; filtering the mixture with a 120-mesh nylon sieve to remove impurities; and adding the mixture as well a stabilizer, white sugar and whey protein into pure milk at the same time for mixing. The method has the advantages that: food alcoholic relief instead of medicament relief is adopted; and the sour milk has high nutritive value and can protect gastric mucosa from damages of alcohol, improve the detoxifying function of the liver, reduce the interference of the alcohol with human metabolism and effectively prevent and treat headache, sickness, hangover and other symptoms caused by drunkenness.

The invention discloses a dealcoholic sobering-up pharmaceutical preparation and a preparing method thereof; the pharmaceutical preparation is prepared by poria, hawthorn, pueraria, ganoderma lucidum, and hoveniae semoveniae semen. Compared with the prior art, the pharmaceutical preparation has very significant dealcoholic sobering-up effect, protects gastric mucosa, does not hurt the gaster, adjusts gastric motility in two ways, inhibits vomiting, nausea and abdominal distention, directly decomposes alcohol and improves capacity for liquor, resists hypnosis and alleviates headache and head halo, speeds up the emptying time of alcohol in the intestine and gaster, reduces the metabolism burden of the liver and kidney, accelerates the alcohol metabolism in the blood, protects the liver, enhances the immunity and relieves the fatigue. The pharmaceutical preparation is prepared by pure natural plants, and has less medicinal odor, easy quality control, and excellent effects for protecting liver, nourishing gaster and strengthening spleen.

Disclosed is an oral administered compound colloid pectin bismuth preparation which comprises colloid pectine bismuth, antibiotics and antibacterial agent. The preparation process comprises dressing antibiotics and antibacterial agent micro-pellet core, mixing with colloid pectine bismuth and medically acceptable amount of excipient. After administration, the colloid pectine bismuth can form a membrane for the protection of gastric mucosa in stomach.

The invention discloses a sinomenine or an enteric-coated controlled-release tablet of hydrochloride thereof. The prepared enteric-coated controlled-release tablet hardly releases the drug in artificial simulated gastric juice, but can slowly and smoothly release the drug in artificial simulated intestinal juice; the sustained release time of the drug can achieve more than 12 hours or even 24 hours; the enteric-coated controlled-release tablet is taken once or twice daily, the plasma drug concentration in vivo is smooth, and the peak-valley phenomenon of the plasma drug concentration is reduced; as the prepared enteric-coated controlled-release tablet hardly releases the drug in stomach, the contacted concentration of the drug with the gastric mucosa is small, the stimulation of the stomach caused by the drug is alleviated. As the prepared enteric-coated controlled-release tablet sustainedly slowly releases the drug in intestinal tract, the times of the drug administration are reduced, and the patient compliance is improved, thereby being applicable to the needs of the clinical development.

The invention relates to the field of medicines, in particular to an alcohol-expelling kidney-tonifying tablet candy which is prepared from maca, turnjujube, kudzu vine roots, dried tangerine or orange peel, fructus amomi, poria cocos, gorgon fruit, Chinese yam, liquorice, lycium barbarum, rhizoma polygonati, cinnamon and alpinia oxyphylla as raw materials. The alcohol-expelling kidney-tonifying tablet candy has the effects of expelling alcohol, protecting the liver, enriching essence and blood, preventing fatigue, protecting gastric mucosa and the like, is applicable to drunkenness and people needing to expel alcohol after being drunk, and is also applicable to people suffering from kidney deficiency with the symptoms such as body fatigue, waist and knee pain, cold intolerance, erectile dysfunction and insomnia and dreamful sleep, and is applicable to customers to take for a long time due to the warm but not dry medicinal property.

The invention discloses a magnetic assisted tensioning device for digestive endoscopy surgery, which comprises an in-vitro electromagnet and also comprises an in-vivo branch matched with the in-vitro electromagnet, wherein the in-vivo branch is composed of an in-vivo magnet and micro-surgical forceps which are connected through connecting lines. The tensioning of the focus is completed by utilizing magnetic attraction to achieve the purpose of surgical field exposure. The magnetic assisted tensioning device is especially suitable for lower excision of the gastric mucosa through the digestive endoscopy. By using the device, a tensioning instrument can be used without occupying the operation channel of the digestive endoscopy, the surgical field exposure is still sufficient when the focus is excised, and the focus with the diameter greater than 20mm of the body of the stomach and duodenum can be possibly excised through the digestive endoscopy, thereby expanding the indications of the endoscopy surgery, meeting the requirements of more patients for minimally invasive surgery, and avoiding the wound to a patient due to the laparotomy.

Helicobacter based preparations comprising a pharmacologically active molecule of interest are disclosed, as well as methods of preparing and using said preparations. In particular, Helicobacter pylori vectors, vector plasmids and recombinant cells that include a sequence encoding a pharmacologically active molecule of interest useful in therapeutic treatments and / or vaccination against disease are provided. Delivery of the pharamacologically active molecules is provided at the mucosal surface, such as the gastric mucosa or nasal membranes, to provide effective and continuous delivery of a pharmacologically active agent. Vectors and shuttle vector constructs are also provided

The invention relates to the field of tobaccos, and particularly relates to a gastric mucosa protected mouth-holding type smokeless tobacco product and a preparing method thereof. The gastric mucosa protected mouth-holding type smokeless tobacco product comprises, by weight, 15-60 parts of a tobacco material, 0.1-10 parts of a gastric mucosa protected traditional Chinese medicine agent, 0.5-5 parts of a saline taste agent, 0-20 parts of a sweetening agent, 0.5-6 parts of an acidity regulator, 0.5-15 parts of a natural flavoring agent, 1-5 parts of a humectant, 1-10 parts of polybutene, 0.005-1 part of an antioxidant, 0.005-0.5 part of a corrosion remover and 40-60 parts of moisture. The mouth-holding type smokeless tobacco product is comfortable in taste and appropriate in strength; the problems of the discomfort stomach, gastric mucosal lesion and the like caused by intake of a large amount of nicotine in the smoking process of an existing mouth-holding type smokeless tobacco product are solved, and the effect of protecting the gastric mucosa is achieved.

The invention provides a solanum dulcamara total saponins extract containing 10-90% of solanum dulcamara total saponins by weight, which is a total steroidal saponins made from traditional Chinese medicine solanum dulcamara by process of extracting, separating and refining. Animal tests shows that: the exact has substantial effects of anti-inflammatory, anti-tumor, helicobacter pylori inhibition, gastric mucosa protection and keratinocyte proliferation inhibition, can be used in the preparation of medicaments for treating gastritis, stomach and duodenal ulcer stomach cancer and psoriasis.

The invention relates to astragalus dandelion soup for treating chronic atrophic gastritis. The astragalus dandelion soup is prepared from 25 to 35 grams of astragalus, 15 to 25 grams of dandelion, 15 to 25 grams of white paeony root, 7 to 13 grams of finger citron and 7 to 13 grams of liquoric root. The astragalus dandelion soup also comprises 25 to 35 grams of pilose asiabell root, 10 to 20 grams of largehead atractylodes rhizome, 8 to 12 grams of cassia twig and 7 to 13 grams of pinellia tuber, or 7 to 13 grams of bupleurum and 8 to 12 grams of bitter orange, or 12 to 18 grams of adenophora, 11 to 19 grams of dwarf lilyturf tuber and 10 to 20 grams of dendrobium or 12 to 19 grams of Chinese angelica, 7 to 13 grams of cattail pollen and 8 to 12 grams of trogopterus dung. The astragalus dandelion soup integrates the functions of improvement, elimination, clearing, moderation, increasing and reduction, has the effects of regulating qi, dredging deposit, tonifying qi, eliminating mass, detoxification and growing muscle, improves the blood circulation of gastric mucosa and can remove clinic symptoms and reverse gland atrophy.

The invention relates to chili sauce capable of reducing blood sugar and a preparation method of the chili sauce. The chili sauce is characterized by being prepared from the following raw materials in parts by weight: 200-210 parts of dry red chili, 10-11 parts of shelled corn, 8-9 parts of wild cabbages, 10-11 parts of Chinese yam, 12-13 parts of litchi flesh, 4-5 parts of mulberry leaves, 1-2 parts of radix puerariae, 3-4 parts of rhizoma anemarrhenae, 2-3 parts of corn stigmas, 12-13 parts of Chinese mesona herb, 35-40 parts of milk powder, 10-11 parts of lactobacillus plantarum, 30-35 parts of table salt, 25-30 parts of cane sugar and 0.4-0.5 part of CaCl2. The chili sauce disclosed by the invention uses the dry red chili as the raw materials, so that the technological process of concentration can be omitted; the lactobacillus plantarum for fermenting the chili sauce is resistant to acid and salt, so that the fermented chili sauce is high in quality; an appropriated amount of CaCl2, an appropriated amount of table salt and an appropriated amount of cane sugar are added, so that chili in the chili sauce is moderate in hardness, good in mouth feel, good in saline taste, and good in color; milk powder added at the later state of fermentation forms gel through the fermentation to be cladded on the surface of the chili, so that stimulation to gastric mucosa is reduced; the Chinese mesona herb can prevent people from suffering from excessive internal heat. In addition, the chili sauce disclosed by the invention can also be used for reducing the blood sugar.

A health-care food for protecting gastric mucosa contains chitosan (15-95 wt.%) and carragheenin (5-85 wt.%), and is prepared from the edible marine living things through extraction and separation of effective components. Its advantages are high effect and no by-effect.

The invention aims to provide a montmorillonite loaded calcium hydroxide antacid which uses montmorillonite loaded calcium hydroxide as the antacid on the basis of acid activation of montmorillonite loaded calcium hydroxide, and solves the conventional problem caused by direct contact of active components of the antacid and the gastric mucosa, wherein the montmorillonite has a gastric mucosa protection function simultaneously. The montmorillonite loaded calcium hydroxide antacid is characterized in that the antacid takes medicinal montmorillonite as the raw material, the montmorillonite is taken as a carrier after acid activation, loaded calcium hydroxide serves as an active ingredient, fatty acid is adopted for surface modification, the carrier of the obtained antacid is stable and insoluble, calcium hydroxide serving as the active ingredient can be continuously and firmly loaded on the carrier, the alkaline intensity is weakened, excessive taking of the antacid cannot cause too high gastric pH, and further, the carrier improves the dispersibility of calcium hydroxide serving as the active ingredient and forms a protective barrier, so that mucosa stimulation is avoided.

The invention discloses a composition used for protecting gastric mucosa and an application thereof. The active components of the composition are prepared from the following raw materials in parts by weight: 55-85 parts of monkey head mushroom, 44-131 parts of poria cocos, 37-83 parts of radix astragali, 36-93 parts of dangshen. The composition is prepared by adopting a scientific and reasonable production technology based on the traditional Chinese medicine life cultivation and health preservation theory, is clear and definite in functions, controllable in quality and safe to take; and all the components in the composition are matched and cooperated, and auxiliary materials are added for conditioning the taste, so that the composition is better in taste and easier to take. The composition has a good effect of protecting gastric mucosa, not only can alleviate stomach discomfort symptoms, but also can play a preventive effect on gastric diseases.

The present invention belongs to the field of biotechnology and particularly relates to a composition for the auxiliary protection of gastric mucosa and / or the remission of gastrectasia and a microecological preparation thereof. The composition for the auxiliary protection of gastric mucosa and / or the remission of gastrectasia is prepared through the synergistic combination of traditional Chinese medicines homologous in medicine and food, and probiotics. The traditional Chinese medicines homologous in medicine and food are composed of hericium erinaceus and poria cocos. The microecological preparation is prepared by the above composition and preparation auxiliary components. According to the technical scheme of the invention, the composition is prepared through the synergistic combination of traditional Chinese medicines homologous in medicine and food, and probiotics, so that the composition can well protect the gastric mucosal lesion and / or the gastrectasia. Meanwhile, the composition can adjust the balance of intestinal flora and improve the resistance. The traditional Chinese medicines homologous in medicine and food, and the probiotics play effects synergistically and promote each other, thus entirely regulating the body constitution and maintaining the normal health status.

There are described a simple examination method of infection with Helicobacter pylori possibly presenting in a gastric mucosa, and a device therefor. The examination is conducted by collecting gas in gastric cavity, and measuring mainly ammonia and additionally organic amines which are generated due to activities of the bacilli. The measurement is carried out by leading the gas in gastric cavity into oral cavity by vomiting-reflex, and sucking the gas by a metering suction pump through a gas detection tube to read-out a length of color-changed area in the gas detection tube.

The invention relates to a compound fungal polysaccharide preparation having functions of supporting healthy energy, strengthening spleen and stomach and boosting immunity. The preparation is mainly prepared from the following raw materials in percentage by weight: 10-50% of grifola frondosa, 10-50% of hericium erinaceus polysaccharide, 5-35% of ganoderma lucidum polysaccharide and 5-35% of pachymaran. Traditional Chinese medicine holds that supporting healthy energy is to build up healthful vital energy and consolidate essence, namely boosting the immunity, enhancing the disease resistance of a human body, preventing diseases and keeping away from sub-health. The grifola frondosa and the hericium erinaceus polysaccharide medicinal and edible fungal polysaccharides are capable of boosting immunity, protecting gastric mucosa, and improving such adverse reactions of tumor chemotherapy as lack of appetite, emesis, nausea and leucopenia. Traditional Chinese medicine thinks that lucid ganoderma (ganoderma lucidum polysaccharide) and poria cocos (pachymaran) can invigorate qi and strengthen spleen, and calm heart and nerves; modern researches prove that the preparation can boost immunity, resist tumors, assist in cancer therapy, and treat insomnia and dyspepsia. In conclusion, through rational combination of the four fungal polysaccharides, the preparation has clear functions of supporting healthy energy, strengthening spleen and stomach and boosting immunity, and has an obvious healthcare effect on sub-health; meanwhile, the preparation can be used for improving adverse reactions of tumor chemotherapy.

The invention relates to a preparation method of the effective part of Hippophae rhamnoides. The method includes: crushing and screening aired Hippophae fruits or post-pressing Hippophae fruit residue, heating ethanol for reflux extraction, collecting extract, performing reduced-pressure recovery on the ethanol, condensing, enriching the condensate with macroporous resin, and vacuum-drying to obtain the total effective part of Hippophae rhamnoides. Hippophae rhamnoides contains 75-85% of the total effective part. The total effective part contains 35-50% of triterpene and 32-45% of total phenols. The results of in-vitro anti-oxidization and anti-bacteria experiments and bioactivity experiments show that the effective part of Hippophae rhamnoides is high in capacity of clearing free radicals in 2, 2-azino-bis(3-ethyl- benzothiazole-6-sulfonate) diammonium salt, high in inhibition on Staphylococcus aureus, and high in oxidation resistance and gram-positive bacterium inhibition. The product obtained by the preparation method is applicable to health foods, drugs, cosmetics or solid drink materials having the functions of protecting liver, lowering blood lipid, age defying, protecting gastric mucosa, antisepsis and anti-inflammation.

A method for the in vivo detection of urease-producing helicobacter in the upper stomach is disclosed. The dense carrier is divided into two separate groups which are combined with separate reagent indicators, one of which also contains urea. The carriers are food soluble products, preferably sugar beads having a diameter of approximately 0.2 to 3.0 mm. The treated carriers and urea are encapsulated in a soluble capsule which is administered to a patient. The density of the carriers cause the capsule to migrate to the gastric mucosa, where the capsule, but not the reagents, is dissolved, placing the reagents and urea in direct contact with the gastric mucosa. The urea reacts with any urease present in the stomach by creating ammonia, which increases the pH in the immediate vicinity of the urea containing carrier and indicator beads. The two reagents react differently, through color change, to the increase in pH, which is viewed through use of an endoscope. A preferred first reagent is bromothymol blue (dibromothymolsulfonphthalein), which changes yellow in the presence of urease, and a preferred second reagent is phenol red (phenolsulfonphthalein), which turns red in the presence of urease.