104 results about "Gastric motility" patented technology

A process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient is provided. The process includes artificially altering, by means of electrical pulses for preset periods of time, the natural gastric motility of the patient to prevent the emptying of or to slow down gastric transit through the stomach to increase the feeling of satiety and / or to accelerate intestinal transit to reduce absorption time within the intestinal tract. More specifically, the electrical stimulation induces tachygastria, which inhibits gastric motility, yields gastric distention, and delays gastric emptying. The tachygastrial electrical stimulation of the stomach, or other portions of the gastrointestinal tract, includes relatively long pulse widths, with lengths of up to 500 milliseconds.

Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.

The invention belongs to the technical field of medicinal and edible formula foodstuffs, and specifically relates to a special diet edible for patients with kidney yin deficiency. Kidney yin means yin-qi and yin-fluid of kidney self, is the yin basis all over the body, and has effects of cooling, moistening, soggy nourishing and limiting excess yang-heat on the whole body. According to the special diet, traditional Chinese medicines with characteristics of whole grains, homology of medicine and food, and new resource foodstuffs are combined together, diet and health preserving are organically combined, so that kidney yin deficiency is conditioned, prevented and resisted. According to the special diet, disease treatment methods as motherland traditional Chinese medicine treasures are inherited, probiotics is creatively utilized as a pioneer and is promoted in propagation, so that microecological balance in intestines is regulated, splenic and gastric motility is enhanced, and drug absorption is accelerated. Probiotics is abundant in multiple active factors, biological immune factors and multiple vitamins. Also according to constitution characteristics of the patients with kidney yin deficiency, multiple natural original-ecological medicinal and edible food materials are added, so that the special diet of the invention has the unique advantage of integration of triple-efficacy comprising dietotherapy, prevention and conditioning.

Compounds having the structure of formula I wherein R1, R2, R3, R4, R5, and R6 are as defined herein, are prokinetic agents and can be used to treat disorders of gastric motility.

9-Desoxoerythromycin compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.

The invention discloses a dealcoholic sobering-up pharmaceutical preparation and a preparing method thereof; the pharmaceutical preparation is prepared by poria, hawthorn, pueraria, ganoderma lucidum, and hoveniae semoveniae semen. Compared with the prior art, the pharmaceutical preparation has very significant dealcoholic sobering-up effect, protects gastric mucosa, does not hurt the gaster, adjusts gastric motility in two ways, inhibits vomiting, nausea and abdominal distention, directly decomposes alcohol and improves capacity for liquor, resists hypnosis and alleviates headache and head halo, speeds up the emptying time of alcohol in the intestine and gaster, reduces the metabolism burden of the liver and kidney, accelerates the alcohol metabolism in the blood, protects the liver, enhances the immunity and relieves the fatigue. The pharmaceutical preparation is prepared by pure natural plants, and has less medicinal odor, easy quality control, and excellent effects for protecting liver, nourishing gaster and strengthening spleen.

The invention discloses a digestion-promoting and intestine-and-stomach-adjusting fruit-and-vegetable probiotic product and a preparing method thereof.The preparing method includes the steps that fruits and vegetables such as cumquat, hawthorn, apple, lemon, banana, pineapple, grapes, pears, sea buckthorn fruits, kiwi fruits, pumpkin, white radish and carrot with the effects of adjusting the intestine and the stomach and promoting digestion are used, powdered sugar in the fruits and the vegetables is fully converted into probiotic thalluses and metabolic products with the two-stage fermentation method, and meanwhile a large quantity of vitamins, microelements and metabolic organic acids in the fruits and the vegetables are reserved; the concentration of the organic acids is adjusted through calcium carbonate to be converted into organic calcium, intestinal absorption can be achieved, and the acor taste is eliminated; as xylitol and prebiotics are adopted to adjust the sweet taste, calcium absorption can be enhanced, and in-vivo probiotic proliferation and the exogenous probiotic planting effect are enhanced.By means of the product, digestion of abdominal-distension persons which are poor in gastric motility is promoted, intestinal flora can be adjusted, calcium daily needed by the human body can be effectively replenished, and if the digestion-promoting and intestine-and-stomach-adjusting fruit-and-vegetable probiotic product is eaten for a long time, the immunity of the human body can be enhanced.

Non-invasive and / or natural orifice procedures, apparatus and methods for modulating the enteric nervous system using one or more energy modalities. A system may include a probe for insertion into a natural orifice (e.g., nasogastrically, orogastrically, nasojejunally) with or without a tube to therapeutically apply energy to modulate one or more portions of the enteric nervous system. The methods described herein may provide energy to stimulate the enteric nervous system to treat disorders such as irritable bowel syndrome, constipation, depression, anxiety and / or to enhance gastric motility, intestinal motility or other neurological responses.

9-Desoxoerythromycin compounds of formula Iwherein R1, R2, R3, R4, and R5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.

Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.

A transdermal patch formulation of a viscous liquid that includes an active agent of incretin or incretin mimetic peptide, a stabilizer, a buffer, a water soluble thickening agent, and a pharmaceutically acceptable carrier. Also, a patch adapted for transdermal delivery of the active agent and having a drug reservoir compartment of the transdermal patch formulation and a system for facilitating transdermal delivery of the active agent through the skin of a subject. The system includes the patch and an apparatus capable of generating a plurality of micro-channels in an area on the subject's skin. The patch and apparatus are used in methods of treatment for reducing blood glucose level, lowering plasma glucagon levels, reducing food intake, or reducing gastric motility in a subject in need of the same by extending the release of the incretin or incretin mimetic peptide in the subject.

The invention discloses a wearable electrical impedance tomography gastric motility information extracting device. The wearable electrical impedance tomography gastric motility information extracting device comprises an electrode array belt, a switch array, an impedance signal measurement module, a DSP and a wireless data transmission module. The electrode array belt is composed of a pasting strip and electrode buckles distributed on the belt at equal intervals and is connected with the switch array through a wire. The switch array is composed of an excitation gating switch and a measurement gating switch. An excitation current source is composed of a DDS multi-frequency signal generation unit and a voltage and current conversion module, and excitation current is injected in a corresponding electrode pair of the electrode array belt through the excitation gating switch. The impedance signal measurement module is composed of an instrumentation amplifier, a programmable amplifier, a demodulator and an AD conversion module. The measurement gating switch picks up impedance signals of the corresponding electrode pair on the electrode array belt and converts the impedance signals into digital information, and the DSP uploads the generated digital information to a portable intelligent device through the wireless data transmission module for processing.

The invention discloses a composition for improving a dissolution rate of a benzamide gastric motility drug. The composition specifically comprises a benzamide gastric motility drug containing at least one amino and / or ammonium salts thereof as well as at least one organic acid. The composition disclosed by the invention generates a local acidic microenvironment after being dissolved, and therefore, the influence of a pH value of a medium on the dissolution rate of the active ingredients is slight, and non-pH dependence dissolution is realized. Therefore, a high dissolution rate also can be realized under the condition that pH value in a digestive tract greatly changes, so that the influence of differences in diet or constitution on the curative effect of the drug is reduced, the dissolution rate of active ingredients of the drug can be effectively improved, and the bioavailability is improved. The composition is low in production cost and easy to use and can realize non-pH dependence release of the active ingredients of the drug. Moreover, a prescription of the composition disclosed by the invention does not comprise a surfactant, and the composition is suitable for a patient sensitive to the surfactant.

The invention relates to an automatic bag changing defecation nursing bed using method. The automatic bag changing defecation nursing bed comprises a foldable nursing bed, a defecation bar, a distribution block, a tray, a defecation pipe, an automatic bag discharging box, a bag opening sealing partition device, a control device, a power supply device and the like, wherein the tray is arranged atthe hip opening position of the foldable nursing bed; the defecation pipe is arranged in the middle of the tray; the automatic bag discharging box and the bag opening sealing partition device are arranged at the tail end of the defecation pipe; the defecation bar is arranged in the middle of the defecation pipe; the tail end of the defecation bar is connected with the distribution block through the defecation pipe; and a massager is arranged at the head of the foldable nursing bed. The bed is simple to operate, can realize intelligent control, not only has a good cleaning effect on constipation, but also can clean residual excrement in rectal folds; after cleaning, probiotic solution is sprayed on the inner wall of the rectum, so that the bed is helpful for improving intestinal microecological environment and enhancing gastric motility.

The invention discloses an immediate release cinacalcet hydrochloride preparation and a preparation method thereof. The immediate release cinacalcet hydrochloride preparation comprises a tablet core and a coating material, wherein the tablet core is prepared from the following ingredients in percentage by weight: 10%-50% of cinacalcet hydrochloride, 27%-54% of pregelatinized starch, 13%-26% of microcrystalline celluloses, 1%-5% of polyvinylpyrrolidone, 1%-10% of crosslinked polyvinylpyrrolidone, 0.05%-2% of colloidal silicon dioxide and 0.05%-2% of magnesium stearate. The immediate release cinacalcet hydrochloride preparation disclosed by the invention is very good in dissolving-out speed, the dissolution rate of the preparation in 0.05mol / L hydrochloric acid is measured at the temperature of 37 DEG C by adopting a USP2 (united states pharmacopoeia) device, and over 85% of the dissolution rate can be achieved at rotation speeds of 75rpm and 50rpm only within 15min, therefore, the preparation can be suitable for patients with weak gastric motility such as children, middle and aged men and the like, and the population taking the preparation of the product is enlarged.

The present invention relates to novel conformationally-defined macrocyclic compounds that bind to and / or are functional modulators of the motilin receptor including subtypes, isoforms and / or variants thereof. These macrocyclic compounds are useful as therapeutics for a range of gastrointestinal disorders, in particular those in which suppression or inhibition of the migrating motor complex (MMC) is effective or malfunction of gastric motility or increased motilin secretion is observed, such as hypermotilinemia, imitable bowel syndrome, dyspepsia, including gallbladder dyspepsia, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, C. difficile associated diarrhea, traveller's diarrhea, acute infectious diarrhea, diarrhea induced by graph versus host disease, other types of diarrhea, functional gastrointestinal disorders, chemotherapy-induced nausea and vomiting (emesis), post-operative nausea and vomiting, cyclic vomiting syndrome and functional vomiting. Accordingly, methods of treating such disorders with such macrocyclic compounds and pharmaceutical compositions thereof are also provided in addition to methods of modulating the migrating motor complex.

The invention discloses a method for simulating and detecting an impedance gastric motility signal. Stomach and tissues surrounding the stomach are simulated by using an elastic solid medium and a liquid medium with different conductivity; the elastic solid medium is pressed by a shifting fork for deformation; and a motor drives the shifting fork to move along the elastic solid medium according to a preset mode under the control of a mechanical electric control unit to generate deformation propagation so as to simulate a gastric peristalsis process. When current is injected from an exciting electrode, the boundary of the liquid medium and the solid medium deforms to change field conductivity distribution; the voltage variation of the boundary is measured from a detection electrode, is amplified, demodulated and transformed and is input into a computer to calculate and analyze an impedance signal; and the impedance change caused by conductivity change is calculated by a sensitivity coefficient method.

The invention relates to an improved intelligent defecation nursing bed which comprises a foldable nursing bed body, an excrement poking rod, a distribution block, a tray, a defecation pipe, a bag opening sealing device, an electric lifting rod, a water tank, a probiotics solution box, an electric gas injection pump, a massager, a control device and a power supply device. The tray is arranged at ahip opening of the foldable nursing bed body, the defecation pipe is arranged in the middle of the tray, the bag opening sealing device is arranged on the lower portion of the defecation pipe, the excrement poking rod is arranged in the middle of the defecation pipe, the tail end of the excrement poking rod penetrates the defecation pipe and is connected with the distribution block, the electriclifting rod is connected with the excrement poking rod, the water tank, the probiotics solution box and the electric gas injection pump are connected with the excrement poking rod through pipelines, and the massager is arranged at a head of the foldable nursing bed body. The improved intelligent defecation nursing bed is simple to operate, can be intelligently controlled, constipation is effectively cleaned, overnight excrement remained in rectum wrinkles can be cleaned, the inner wall of the rectum is coated with probiotics solution after cleaning is completed, micro-ecological environments of an intestinal tract are improved, and gastric motility is enhanced.

The invention discloses a drug for eliminating toxic side effects of radiotherapy and chemotherapy, which comprises raw materials in the following weight portion: 10 to 20 portions of rhizoma atractylodis macrocephalae, 10 to 20 portions of red ginseng, 10 to 20 portions of tuckahoe, 10 to 20 portions of coke hawthorn, 10 to 20 potions of fried rice sprout, 10 to 20 portions of massa fermenta, 5 to 10 portions of gizzard pepsin, 10 to 20 portions of dried orange peel, 5 to 10 portions of amomum fruit, and 10 to 20 portions of elecampane. The drug uses the coke hawthorn, the massa fermenta, the fried rice sprout and the gizzard pepsin as monarch drugs in a prescription for strengthening the spleen and stomach, removing food retention and dissolving stasis, and improving the gastric motility, uses the red ginseng and the rhizoma atractylodis macrocephalae as ministerial drugs for invigorating the spleen and benefiting Qi, and strengthening healthy energy and preventing cllapse, uses the elecampane and the dried orange peel as adjuvant drugs for refreshing the spleen, promoting the circulation of Qi and regulating middle warmer, and uses the amomum fruit as a dispatcher drug for promoting the circulation of Qi, eliminating damp and nausea, and uses the tuckahoe also as a dispatcher drug for smoothing the nerves to treat palpitation, wherein the monarch drugs, the ministerial drugs, the adjuvant drugs and the dispatcher drugs are used together for promoting digestion and removing food retention, strengthening the spleen and replenishing Qi, promoting the circulation of Qi and regulating middle warmer, and eliminating damp and refreshing the spleen so as to recover the gastric motility, increase the appetite of a patient and improve the physical force of the patient. The drug plays a very important role in resisting and treating diseases. Clinical aplications show that the effective rate of the drug is more than 90 percent.

The invention discloses a drug combination for promoting digestion and relieving stasis and a preparation method thereof. The effective components of the invention are extracted from more than ten of medicinal materials including codonopsis pilosula, atractylodes, poria, fructus chebulae, Galangal Seed, dried ginger, amomum, agastache rugosa, wide radix aucklandiae, malt, cynanchum root, lotusty, Chinese yam, focal medicated leaven, radish seed, etc. the unique active components of drugs provided by the invention have strong function in promoting digestion and relieving stasis, the drug combination can strengthen the amount of secretion, the acidity and the digestive ability of gastric juice and gastric motility and can accelerate the gastric emptying velocity and is applied to infantile anorexia.

The invention relates to a feed, in particular to a beef cattle fattening feed. The beef cattle fattening feed is prepared from, by weight, 100 parts to 120 parts of corn, 30 parts to 50 parts of bran, 20 parts to 40 parts of bean cakes, 1 part to 1.5 parts of salt, 10 parts to 15 parts of oat, 20 parts to 40 parts of potato starch, 30 parts to 60 parts of corn straw, 10 parts of white sugar, 1 part of traditional Chinese medicine additive and 0.5 part of leavening agent. According to the beef cattle fattening feed, as the traditional Chinese medicine additive is contained, the gastric motility of beef cattle can be promoted, and the digestive absorption capacity of beef cattle can be improved. Due to leavening, a part of the concentrated feed can be directly converted into ingredients such as amino acid and proteins, rapid absorption of beef cattle is facilitated, and stomach food retention is reduced. After the feed is adopted for a long time, the level of the gastric motility of beef cattle can be effectively improved, digestive absorption can be promoted, and the yield of beef can be increased.

The present invention discloses a public nutritional supplement food which is prepared from a variety of beans, cereals and other coarse cereals. The formula food contains three major nutrients of vitamins, trace elements and dietary fibers, contains a variety of cereals with skins, is rich in nutrition, is reasonable in ingredient matching, can meet human body supplementary requirements for vitamins and trace elements, is free of any additives, and has original flavor of natural food. The nutritious food is scientifically matched according to the climate change in seasons, can meet the daily nutritional needs of human body with consumption of 100-150 grams each day, and can not only satisfy hunger, but also can supplement blood and qi, improve microcirculation, promote intelligence and nourish skin, prevent white hair and aging, and enhance gastric motility and vascular elasticity. The public nutritional supplement food has prevention and mitigation functions in hypertension, coronary heart diseases, arteriosclerosis, and other cardiovascular and cerebrovascular diseases, has relative high nutritional and immune functions, and is beneficial to human health in a long-term consumption.

A preparation method of a momordica grosvenori and chrysanthemum tea beverage. Momordica grosvenori has a sweet taste, is cool in property, can dispel internal fire, and has the health-caring functions of clearing heat, detoxifying body, moistening lung, boosting liver, engendering fluid, relieving thirsty, relieving cough, resolving phlegm, moistening intestines and relaxing bowel, and inhibiting asthma when being drunk for a long time; chrysanthemum has the effects of reducing blood pressure, killing cancer cells, enlarging coronary artery and inhibiting bacteria, and can increase calcium in human body, regulate myocardial functions and reduce cholesterol when being drunk for a long time, and is suitable for middle aged and elderly people and prevention of epidemic conjunctivitis; oligosaccharide belongs to prebiotics and can alleviate constipation, prevent and relieve intestinal diseases, balance micro-ecology in intestine, reduce concentration of blood fat, alleviate diseases in nervous system, improve absorption of minerals, enhance immune system, delay senility and improve gastric motility, thereby achieving the effects of detoxifying body and relaxing bowel, clearing fat and nourishing face, maintaining skin health and improving body health. The momordica grosvenori and chrysanthemum tea is a popular health-caring beverage, and has important significances for improving health level of people in our country and preventing diseases.

Motilide compounds having the formula (I), wherein R1, R2, R3, and R4 are as defined herein, and methods for their preparation and use in the treatment of diseases or conditions characterized by impaired gastric motility.

The invention relates to a traditional Chinese medicine preparation and a preparation method thereof and particularly relates to a traditional Chinese medicine preparation for treating chronic gastritis and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by mass: 8-10 parts of cuttlebone, 15-20 parts of dandelion, 1-2 parts of alum, 3-5 parts of liquorice, 3-5 parts of olibanum, 10-15 parts of myrrh, 5-10 parts of rhizoma corydalis, 5-10 parts of panax notoginseng and 10-15 parts of coptis chinensis. The traditional Chinese medicine preparation has the advantages that the used traditional Chinese medicines conform to the regulations of pharmacopoeia of the people's republic of China, and the traditional Chinese medicine preparation is safe and reliable. Through matching all the traditional Chinese medicine raw materials, the traditional Chinese medicine preparation has the effects of resisting to gastric ulcer, gastritis and the like, also has the effects of strengthening body resistance and eliminating evil, stopping bleeding and relieving pain, regulating gastrointestinal malfunction, promoting gastric motility and restoring the normal gastrointestinal function and has the characteristics of exact curative effect, rapidness for taking effects, high curative ratio, no side effects and the like when being used for treating chronic gastritis.

The present invention discloses a composition having a digestion promoting function. The composition comprises the following raw material components in parts by weight: 5-7 parts of haws, 4-6 parts of malts, 1-3 parts of dried tangerine peels, 1-3 parts of radix pseudostellariae and 3-7 parts of rhizoma atractylodis macrocephalae. The present invention also discloses a preparation method of the composition. Water at an amount of 8-12 times of a total weight of the raw material components is added, the raw material components are boiled for 2-3 times, and a boiling method is as follows: after heating and boiling out, the raw material components are slightly boiled for 0.5-1.5 h; extracts are mixed, the mixed extract is concentrated to a relative density of 1.1-1.2 and the concentrated extract is dried under a reduced pressure to prepare dry extractum. The present invention also discloses an application of the composition in preparing health-care food having the digestion promoting function. The composition aims at a mechanism of dyspepsia, is scientifically matched by using theories of traditional Chinese medicines and modern medicines, and reaches the functions of promoting digestion by helping digestion and relieving stasis, strengthening spleen and benefiting qi, nourishing stomach and stimulating appetite, enhancing gastric motility, promoting gastrointestinal emptying, etc.

The invention relates to the field of drug formulae, in particular to a traditional Chinese medicine for treating gastric ulcer. The traditional Chinese medicine is characterized by being prepared from the following raw materials in parts by weight: 77-87 parts of oroxylum indicum, 41-51 parts of greek valerian, 25-35 parts of radix ceratostigmae, 33-43 parts of roundleaf dutchmanspipe root, 25-35 parts of semen aesculi, 18-28 parts of fingered citron, 21-31 parts of bulbiferous stonescrop, 19-29 parts of amomum cardamomum, 14-24 parts of allium macrostemon, 20-30 parts of alpinia katsumadai, 13-23 parts of adiantum, 16-26 parts of semen cuscutae, 10-20 parts of dioscorea cirrhosa, 37-47 parts of jasminum grandiflorum, 24-34 parts of polygonum orientale fruit, 26-36 parts of pterocephalus hookeri, 8-18 parts of perfoliote knotweed herb, 6-16 parts of dwarf galangal rhizome and 8-18 parts of raspberries. The raw materials are mixed, soaked with water, decocted and subjected to residue removal to obtain filter liquor. The traditional Chinese medicine has a remarkable treatment effect on epigastric pain, gastric ulcer and duodenal ulcer, can improve the gastric motility and recover normal metabolism of the stomach, is long in action time, short in treatment course, quick-acting, safe and free of toxic and side effects, and can be widely applied to clinical treatment of the gastric ulcer.

The invention provides various devices for delivering Glucagon-Like Peptide-1 (7-36), in various infusion patterns and rates, to optimally stimulate carbohydrate metabolism, to inhibit gastropancreatic secretion and gastric motility, and to treat various disease conditions (including diabete) as described in the instant specification. The devices and methods of the invention provide various ways to deliver doses (escalating, constant, on demand, etc.) of GLP-1 in response to different patient need.

The invention relates to a use method of an improved intelligent defecation nursing bed. The improved intelligent defecation nursing bed comprises a foldable nursing bed body, an excrement poking rod,a distribution block, a defecation pipe, a bag opening sealing device, an electric lifting rod, a water tank, a probiotics solution box, an electric gas injection pump, a control device, a power supply device and the like. A tray is arranged at a hip opening of the foldable nursing bed body, the defecation pipe is arranged in the middle of the tray, the bag opening sealing device is arranged on the lower portion of the defecation pipe, the excrement poking rod is arranged in the middle of the defecation pipe, the tail end of the excrement poking rod is connected with the distribution block, the electric lifting rod is connected with the excrement poking rod, the water tank, the probiotics solution box and the electric gas injection pump are connected with the excrement poking rod throughpipelines. The improved intelligent defecation nursing bed can be intelligently controlled, constipation is effectively cleaned, overnight excrement remained in rectum wrinkles can be cleaned, the inner wall of the rectum is coated with probiotics solution after cleaning is completed, micro-ecological environments of an intestinal tract are improved, and gastric motility is enhanced.

The purpose of the present invention is to provide a traditional Chinese medicine for treating chronic atrophic gastritis and a preparation method thereof, wherein the traditional Chinese medicine includes cassia twig, red ginseng, poria, amomum fruit, alpinia fruit, baked ginger, ginger, cardamom, and prepared pinellia. The traditional Chinese medicine of the present invention has good reversal, alleviating or eliminating effect to intestinal metaplasia pathological changes of chronic atrophic gastritis, and currently, no obvious adverse reactions and side effects are found, so the medicine is safe and reliable. The traditional Chinese medicine of the present invention has good gastric motility promoting effect, and can also be applied to the treatment of patients having functional gastrointestinal disorders with poor gastrointestinal motility, such as the gastroesophageal reflux disease, bile reflux gastritis, functional dyspepsia, diabetic gastroparesis and functional constipation.